Engineering Commons^™

The Mathematical Relationship Among Normal Patellar Dimensions, To Find The Pre-Diseased Patellar Thickness In Different Populations, Mahdie Kerdari, Shima Rastegar, Yasmeen Mustafa, Mohammadreza Abbassian, Armin Aalami Harandi, Mary M. Stahle, Robert Hube, Hamid Rs Hosseinzadeh

Henry M. Rowan College of Engineering Departmental Research

Whether resurfacing or not resurfacing the patella during total knee arthroplasty (TKA) still is a challenge to orthopedic surgeons. A significant reason for this controversy is the far from perfect outcomes of both techniques, resulting from inadequate knowledge of normal patellar dimensions in a diseased one. The primary purpose of the current study is to find the pre-diseased patellar dimensions and the ethnic differences in patellar dimensions. We measured the patella's dimensions on 927 normal young adult knee MRIs from seven different ethnicities. Besides comparing the dimensions between sexes, ages, and sides, we analyzed the differences among ethnic groups. The …

Framework For Water Management In The Food-Energy-Water (Few) Nexus In Mixed Land-Use Watersheds In Colombia, Camilo Torres, Margaret Gitau, Jaime Lara-Borrero, Diego Paredes-Cuervo

Purdue University Libraries Open Access Publishing Fund

The food-energy-water (FEW) nexus approach has emerged as an alternative for managing these resources more efficiently. Work from studies conducted in the FEW nexus in Latin America is scarce in the scholarly literature. This study aims to develop a framework for water management at the FEW Nexus, with a focus on Colombia. The study focuses on a typical mixed land-use watershed in the Andean region with specific objectives being to: (1) characterize the watershed with respect to land use, climate, water resources, and other factors pertinent to the nexus; (2) explore the relationship between factors in the FEW nexus that …

Laboratory Scale Anaerobic Reactors For Bioenergy From Wastes: Materials, Mathematical Models, And Stoichiometry, Yehor Pererva

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Anaerobic processes are being explored for the production of bioenergy in the form of biomethane and biohydrogen in a "waste-to-value" approach that considers wastes as a resource. Laboratory scale Biomethane potential (BMP) tests and Up-Flow Anaerobic Sludge Blanket (UASB) reactors can be used to indicate the potential recovery of bioenergy from industry wastes. The goals of this research were to: (1) conduct a critical review of models for determining biomethane potential, (2) develop a theoretical relationship for stoichiometry for biomethane and biohydrogen from wastes, and (3) develop key design aspects for geometry and infrastructure, including gas-liquid-solid separation in laboratory UASB …

Annual Simulation Of Photovoltaic Retrofits Within Existing Parabolic Trough Concentrating Solar Powerplants, Nipun Goel, Hannah O'Hern, Matthew Orosz, Todd Otanicar

Mechanical and Biomedical Engineering Faculty Publications and Presentations

Solar power for electricity production comes from either photovoltaics or concentrating solar power plants. The former has seen rapid growth and expansion due to the rapid fall in global prices, while the latter has seen moderate growth due to ability to cheaply store thermal energy for later use. Hybridization, or combining photovoltaics with concentrating solar power represents a potential way for lowering cost while enabling long term storage. Over 5 GW of capacity exist worldwide using parabolic trough style technology for concentrating solar power which presents a unique option for optimization in the form of a photovoltaic retrofit. While it …

Bacteria Analysis By Using A Supervised Machine Learning Algorithm Based On Droplet Microfluidics, Yulder Daniel Angarita

Electronic Theses and Dissertations

Sepsis is a major medical problem and massive resources have been invested in developing and evaluating alternative treatments. Statistics indicate that sepsis causes between one third and one half of all hospital deaths in the United States. Sepsis has a high impact on health care in the US, with direct sepsis costs in 2009 exceeding $15.4 billion. A research study found that a 1-hour delay in appropriate antimicrobial care resulted in a 7% - 10% rise in mortality. Several professional societies seek to reduce sepsis mortality by targeting the timely use of diagnostic tests and antimicrobial therapy. The diagnostic instruments …

Cervis: Cervical Cancer Early Response Visual Identification System, Kira Palazzo, Lauren Serfas, Juliana Trujillo

Bioengineering Senior Theses

The goal of CERVIS is to increase screening for cervical cancer through the development of a low-cost, minimally invasive screening procedure for women in low-resource settings that requires minimal healthcare expertise. There currently exist two primary screening procedures: the Pap smear, primarily used in developed countries, and visual inspection with acetic acid (VIA), primarily used in low and middle-income countries (LMICs). Both of these procedures require a high degree of healthcare training in order to administer and interpret, and are highly invasive, requiring direct interaction with the cervix. Our alternative procedure utilizes a particular bacteria, Fusobacterium nucleatum , within the …

Isolation And Selective Glycosylation Of Antisalmonellal Anthraquinones From The Stem Bark Of Morinda Lucida Benth. (Rubiaceae), Napoleon A. Mfonku, James A. Mbah, Norbert Kodjio, Donatien Gatsing, Jixun Zhan

Biological Engineering Faculty Publications

In this work we report the isolation, identification and antibacterial activity of two anthraquinones, 2-hydroxy-1-methoxyanthraquinone (1) and 2,5-dihydroxy-1-methoxy-6-methoxymethylanthraquinone (2), from the stem bark of Morinda lucida. These two natural products were selectively converted into two new glycosylated derivatives, 2-hydroxy-1-methoxyanthraquinone-4′-O-methyl-2-O-β-d-glucopyranoside (3) and 2,5-dihydroxy-1-methoxy-6-methoxymethylanthraquinone-4′-O-methyl-2-O-β-d-glucopyranoside (4) by the filamentous fungus Beauveria bassiana ATCC 7159. Structure elucidation was accomplished based on the 1D and 2D NMR, IR and mass spectra. The glycosylated compounds 3 and 4 showed higher in vitro antibacterial activity against Salmonella enterica subsp. enterica sérovars Typhimurim (MIC of 8 μg/mL each) than the corresponding aglycons 1 and 2 (MIC of …

Global Joint Registry: Analysis Of Revision Hip Arthroplasty Data, Alicia M. Runser

Browse all Theses and Dissertations

Total hip arthroplasty (THA) has become well-known as being one of the most successful procedures with much long-term positive clinical results. However, revision surgeries are still required. The four most common failure modes for THAs, “reasons for revision”, are loosening, dislocation or instability, fracture, and infection. The goal of a hip arthroplasty register is to gather information on patients that undergo a total hip arthroplasty and factors pertaining to their surgery which may affect their outcome for future years such as the reason for revision. Analysis of this data can help with the allocation of healthcare funds and the efficacy …

Characterization Of Bone Pathology In Sickle Cell Disease And Therapeutic Strategies, Mykel D. Green

Dissertations and Theses

Sickle cell disease (SCD) is a genetic hemoglobinopathy that has grown into a global health concern. While the advances in medical treatment and management of SCD during childhood have drastically improved the overall survival of children, the transition from pediatric to adult services is significantly inadequate in comparison. Life expectancies of patients with SCD in first world countries such as the United States are shortened to averages of 42 and 48 years for men and women, respectively. Despite the increasing number of people living with SCD, remarkably, few detailed studies have described the clinical course and complications of the disease …

Microfluidic System For Detectingmalaria-Infected Red Blood Cells Using Impedance Measurementcoupled With Electromagnetic Force, Prapapan Sonridhi

Chulalongkorn University Theses and Dissertations (Chula ETD)

Malaria is one of the most life-threatened diseases caused by Plasmodium parasite. Malaria is preventable and curable, mainly due to the factor of time and management of the spread. In other words, a rapid detection with high accuracy will contribute to more effective treatment process. In this research, we introduced the new technique implemented microfluidics, dealing with the manipulation of blood cells using magnetic force, and impedance measurement measuring the signal changes of electrical impedance between a couple of electrodes. According to the distinct magnetic properties of normal red blood cells and malaria-infected red blood cells, the experiment was designed …

Deep Learning For Digitized Histology Image Analysis, Sudhir Sornapudi

Doctoral Dissertations

“Cervical cancer is the fourth most frequent cancer that affects women worldwide. Assessment of cervical intraepithelial neoplasia (CIN) through histopathology remains as the standard for absolute determination of cancer. The examination of tissue samples under a microscope requires considerable time and effort from expert pathologists. There is a need to design an automated tool to assist pathologists for digitized histology slide analysis. Pre-cervical cancer is generally determined by examining the CIN which is the growth of atypical cells from the basement membrane (bottom) to the top of the epithelium. It has four grades, including: Normal, CIN1, CIN2, and CIN3. In …

Developing A Control System To Better Understand The Effects Of Pyruvate Decarboxylase Activity On Clostridium Thermocellum Metabolism, Nicholas Cervenka

ENGS 88 Honors Thesis (AB Students)

In order for cellulosic biofuels from Clostridium thermocellum to be commercially viable, the ethanol yield and titer of the microbe must be increased. To accomplish this, it has been suggested to introduce the Pyruvate Decarboxylase (PDC) enzyme into C. thermocellum. In order to demonstrate effects on ethanol production by PDC prior to genetic modification, a cell free system (CFS) has been developed. A purified enzyme system was developed with the CFS to function as a control. Using the purified enzyme system, PDC from Saccharomyces cerevisiae was demonstrated to be a good candidate for further testing in the CFS.

Cervis: Cervical Cancer Early Response Visual Identification System, Julia Lanoha, Claire Hultquist, Rosie Mcdonagh, Hallie Mcnamara

Bioengineering Senior Theses

The goal of CERVIS is to make a substantial, positive impact in the cervical cancer screening space through the development of a minimally invasive, cost effective solution that enables women in low-resource settings to test for cervical cancer on a frugal and effective platform. In the developed world, there are a variety of options that can aid in early detection, including Pap smears. However, due to the high cost and laboratory requirements that accompany this procedure, women in low-resource settings rarely have access to this preventative care or regular screenings for cervical cancer. Using new research about the changes in …

An Arm And A Leg: Medtech Perspectives On Human-Centered Design, Evan D. Poff

Marriott Student Review

The art of human-centered design accounts for both technological and emotional specifications in order to deliver meaningful products that meet the specific needs of the individual customer. Every business professional can deepen his or her understanding of human-centered design – regardless of our industry of choice – by looking to perspectives that the business of medical technology offers. To that end, this article draws upon interviews with three figures in this remarkable field, distilling their insights on how to cultivate businesses that produce human-centered solutions.

Fluoride Removal From Water Using A 3d Printed Calcium Carbonate Filter, Sophia Bakar, David Kahler, Benjamin S. Goldschmidt

Undergraduate Research and Scholarship Symposium

Groundwater containing high concentrations of fluoride is the most common source of drinking water in rural areas in parts of east Africa, India, and China. The elevated levels of fluoride cause skeletal and dental fluorosis, which is the weakening and decay of bone structures due to the leeching of calcium from the body as calcium and fluoride bond by the process of adsorption. Over 150 million people are suffering from some form of fluorosis due to the consumption of groundwater. Calcium carbonate has been demonstrated to influence fluoride removal in several forms. To make fluoride removal a cost-effective and user-friendly …

Exploring The Challenges To Sustainable Rural Drinking Water Services In Chile, Jami Nelson-Nuñez, Jeffrey P. Walters, Denisse Charpentier

Faculty Publications - Biomedical, Mechanical, and Civil Engineering

Many countries around the world now face the dual challenges of closing the remaining gaps in access to drinking water in rural areas while further addressing the issues of equity, quality, and sustainability outlined in the new Sustainable Development Goals (SDGs). Our research explores the key factors for sustainability in rural drinking water services in Chile, an important example not only due to its success in rural water access but also because of the new directions the country is taking to achieve the SDGs. Drawing on results from a Delphi study of Chilean rural water experts, we discuss the most …

Cancer Nanotechnology: Enhancing Tumor Cell Response To Chemotherapy For Hepatocellular Carcinoma Therapy, Sun Yongbing, Ma Wen, Yang Yuanyuan, He Mengxue, Li Aimin, Bai Lei, Yu Bin, Yu Zhiqiang

Faculty & Staff Scholarship

Abstract

Hepatocellular carcinoma (HCC) is one of the deadliest cancers due to its complexities, reoccurrence after surgical resection, metastasis and heterogeneity. In addition to sorafenib and lenvatinib for the treatment of HCC approved by FDA, various strategies including transarterial chemoembolization, radiotherapy, locoregional therapy and chemotherapy have been investigated in clinics. Recently, cancer nanotechnology has got great attention for the treatment of various cancers including HCC. Both passive and active targetings are progressing at a steady rate. Herein, we describe the lessons learned from pathogenesis of HCC and the understanding of targeted and non-targeted nanoparticles used for the delivery of small …

A Seed Dormancy Gene-Mediated Biotechnology To Mitigate Transgene Flow Into Weedy Rice, Luai Nahar Muhammad

Electronic Theses and Dissertations

Transgene flows into wild/weedy relatives may cause ecological and economic problems. Seed dormancy is an adaptive trait that distributes germination over time and promotes persistence of weeds in agroecosystems. Silencing natural genes controlling seed dormancy (SD) could promote germination and reduce weed adaptability. The goal of this project was to develop a transgenic mitigation (TM) technology by linking to a primary transgene with an SD gene-silencing structure, as a tandem construct for transformation, to reduce the risk of gene flow into weed populations. In this research, the Bar (Bialaphos) gene for resistance to the glufosinate herbicide was used as a …

3d Printing In Low Resource Healthcare Settings: Analysis Of Potential Implementations, Alenna Beroza

Dissertations, Master's Theses and Master's Reports

3D printing has gained significant momentum in the past ten years, and its unique advantages make it especially ideal for use in low resource healthcare settings, where many designs have already been successfully implemented. Yet, little has been studied on how 3D printing can be sustainably and functionally implemented in low resource healthcare systems as a manufacturing practice. In this report, three business models are proposed for this implementation: In-House Operator, Independent Operator, and Print Farm. These models were then tested over four months in Kisumu county, Kenya, at two workshops and seven public hospitals. I worked with local medical …

Rotary Pump Speed Modulation To Produce Pulsatile Flow And Ventricular Volume Unloading., Connor Joseph Smith

Electronic Theses and Dissertations

Background: Continuous-flow (CF) left ventricular assist devices (LVADs) have gained widespread clinical acceptance as a treatment option for advanced heart failure (HF); however, they have also been associated with an increased risk of adverse events, including gastrointestinal bleeding, aortic insufficiency, and hemorrhagic stroke. It has been hypothesized that the increase in adverse event incidence may be due in part to diminished vascular pulsatility and high shear stress when CF-LVADs are operated at fixed speeds. Previous studies have shown that pump speed modulation generates greater levels of pulsatility in rotary pumps than when operated at fixed speeds. The objective of this …

Cervis: Cervical Cancer Early Response Visual Identification System, Evangelia Bouzos, Ivy Fernandes, Marina Predovic

Bioengineering Senior Theses

Our goal is to make a positive impact in the cervical cancer diagnostic space through the development of an accurate, cost effective solution that enables women in low resource settings to test for cervical cancer on a frugal and effective platform. In developed countries, we rely on regular preventive care, such as pap smears, to identify any cellular abnormalities that may indicate the disease state. However, due to the high cost and laboratory requirements of this procedure, women in low resource settings typically do not have access to this procedure. Since they are not regularly screened and often have little …

Meshr: A Modular, Economical Skin Graft Hand Roller, Maggie Alt, Josée Fournier, Madeline Krenek, Will Paton

Bioengineering Senior Theses

In South Africa and around the world, the rates of severe burns are a significant health issue. Skin grafts are used to improve the function and appearance of the burned area and reduce the amount of time a patient is in the hospital. To minimize the amount of skin needed and maximize the coverage of the graft, the harvested sample is meshed in a lattice pattern so it can expand and graft a much larger surface area. Unfortunately, the current methods and devices used in both high and low-income countries have been optimized for hospitals with larger budgets and more …

Milkguard: Low-Cost, Polymer-Based Sensor For The Detection Of Escherichia Coli In Donated Human Breast Milk, Maggie May, Nicholas Kikuchi, Matthew Zweber

Bioengineering Senior Theses

Breast milk, the gold standard for infant nutrition, could prevent up to 13% of child deaths worldwide. However, many mothers are unable to breastfeed due to health conditions and other factors. Because of this, a network of more than 500+ human milk banks, which collect and distribute donated breast milk to infants, have emerged worldwide. However, operational costs to ensure the safety of this milk remain time-intensive and costly.

There are no existing diagnostics for rapid and on-site detection of bacterial contaminants in donated milk. Currently, many milk banks send samples to outside laboratories for bacterial culturing tests, which take …

Mitochondrial Mrna Translation Is Required For Maintenance Of Oxidative Capacity, David Lee

Graduate Theses and Dissertations

Oxidative metabolism is required to produce adequate energy to sustain human life. A primary example of deteriorating oxidative capacity is seen in the cardiac musculature during chronic heart failure. This suggests that by improving oxidative potential, chronic heart disease could be mitigated and one approach to accomplish this may be through targeting the mt-mRNA translation system. Purpose: This investigation’s purpose was to characterize disruptions in mt-mRNA translation machinery in multiple forms of cardiomyopathy and to determine if mitochondrial mRNA translation initiation factor (mtIF2) is necessary to maintain oxidative capacity in cardiomyocytes. Methods Using a combination of animal and cell culture …

Designing Synthetic Environments To Control Valvular Interstital Cells In Vitro, Kent E. Coombs

Biomedical Sciences ETDs

Aortic valve disease (AVD) is a large contributor to health costs in the United States affecting 2.8% of the population greater than 75 years old. With a growing elderly population due to medical advances, AVD will continue to rise in prevalence over time. Current treatments for AVD are insufficient due to a lack of preventative therapies and the bioprosthetic valves used for surgical replacement have major limitations. Tissue engineered heart valves (TEHVs) present an ideal solution to current AVD needs because of their biocompatibility, capability to integrate with the host’s tissue, and ability to utilize the natural repair mechanisms of …

A Strategic Audit Of Medtronic Plc, Jozzy Carter

Honors Program: Senior Projects (Public)

Humans will always have a need for healthcare, and as the world continues to innovate in the tech space, consumers will demand advances in medicine and medical devices. Medtronic is at the forefront of this innovation but faces intense competition in the medical technologies industry. This poses the question: what can Medtronic do to continue its growth and stay competitive in this space? This paper offers an analysis of Medtronic as a medical device company by offering insight to its competitive advantage, financials, business mix, and value chain. It also analyzes the forces that affect Medtronic using SWOT, PEST, and …

Next Generation Sequencing Technologies For Real-Time Genotyping And Targeted Sequencing For Precision Medicine, Priyanka Rawat

Biomedical Engineering ETDs

Astounding success of Human genome project and accelerating success of sequencing technologies have enabled $ 1000 genome goals possible. But, this is still far-fetched from the reach of many resource refrained populations with high genetic variations causing lethal genetic diseases. Based on present technology principles, I have developed prototypes for affordable, scalable and customizable point-of-care genotyping and targeted sequencing. Ion-sensitive field effect transistors with novel read-out and signal amplification techniques are used for laying foundation of possible ISFET based allele-arrays. Sequencing-by-synthesis based full-fledge sequencer is made with novel immobilization, flow-cell and data acquisition methods for massive sequenciing.

Development Of Starch-Polyvinyl Alcohol (Pva) Biodegradable Film: Effect Of Cross-Linking Agent And Antimicrobials On Film Characteristics, Aniket Satish More, Chandani Sen, Madhusweta Das

Journal of Applied Packaging Research

To satisfy the need of developing eco-friendly flexible antimicrobial packaging film with minimum use of synthetic chemical ingredients, the present study examined the efficacy of citric acid (CA) as cross-linking agent and essential oils (EOs), viz., cinnamon essential oil (CEO) and oregano essential oil (OEO) as natural antimicrobials in corn starch-polyvinyl alcohol (CS-PVA) film. Compared to film prepared from filmogenic solution (FS) containing 75 kg CS+8.75 kg PVA+24.6 kg glycerol per m³ FS, film additionally containing CA at 0.07 kg/kg CS indicated 95% higher ultimate tensile strength (UTS) and 27% lower water vapor permeability (WVP). Film developed with incorporation …

Rice Hull Bioreactor For Recirculating Aquaculture, Marlon A. Greensword

LSU Doctoral Dissertations

The engineering of floating media biofilters has been optimized over the years. The backwashing process has made them more energy and water efficient. Likewise, moving bed bioreactors (MBBR) are gaining interest and popularity because they are relatively affordable to build. Yet, developing countries’ aquaculture production remains largely excluded from the advances made in recirculating aquaculture systems (RAS). This discrepancy is partially driven by the high costs of media such plastic beads and Kaldnes (KMT) media, commonly used in MBBR.

This dissertation evaluates the usability and profitability of rice hulls (RH), an abundant by-product in many developing nations, as a sinking …

Rapid Thermocycler System For Rapid Amplification Of Nucleic Acids And Related Methods, Joel R. Termaat, Scott E. Whitney, Hendrik J. Viljoen, Matthew R. Kreifels

Department of Chemical and Biomolecular Engineering: Patents

A thermocycling device and method of operating a thermocycler instrument, the instrument including a sample holder, at least one thermal cycling element, and at least one first and second temperature sensors, for causing the sample holder containing the at least one sample to undergo polymerase chain reaction amplification by repeated cycling between at least a denaturation heating stage and an aunealing cooling stage. The first temperature corresponding with the temperature of the sample holder is monitored using the at least one first temperature sensor, and a second temperature corresponding with the temperature external of the sample holder is monitored using …