Engineering Commons^™

The Effect Of Platelet-Rich Plasma (Prp) On Muscle Contusion Healing In A Rat Model., Demetris Delos, Matthew J. Leineweber, Salma Chaudhury, Saif Alzoobaee, Yingxin Gao, Scott Alan Rodeo

Faculty Publications

Background: Current therapy for muscle contusions is usually limited to nonsteroidal anti-inflammatory drugs and/or use of the RICE principle (rest, ice, compression, elevation); thus, other forms of treatment that can potentially accelerate the rate of healing are desirable. Hypotheses: A local injection of platelet-rich plasma (PRP) would lead to accelerated healing rates compared with controls; also, delayed administration of PRP would lead to a blunted response compared with immediate treatment. Study Design: Controlled laboratory study. Methods: Forty-six male Lewis rats each underwent a single blunt, nonpenetrating impact to the gastrocnemius muscle via a drop-mass technique and subsequently received either a …