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Full-Text Articles in Engineering
Increasing Label-Free Stem Cell Sorting Capacity To Reach Transplantation-Scale Throughput, Melinda Simon, Ying Li, Janahan Arulmoli, Lisa Mcdonnell, Adnan Akil, Jamison Nourse, Abraham Lee, Lisa Flanagan
Increasing Label-Free Stem Cell Sorting Capacity To Reach Transplantation-Scale Throughput, Melinda Simon, Ying Li, Janahan Arulmoli, Lisa Mcdonnell, Adnan Akil, Jamison Nourse, Abraham Lee, Lisa Flanagan
Faculty Publications
Dielectrophoresis (DEP) has proven an invaluable tool for the enrichment of populations of stem and progenitor cells owing to its ability to sort cells in a label-free manner and its biological safety. However, DEP separation devices have suffered from a low throughput preventing researchers from undertaking studies requiring large numbers of cells, such as needed for cell transplantation. We developed a microfluidic device designed for the enrichment of stem and progenitor cell populations that sorts cells at a rate of 150,000 cells/h, corresponding to an improvement in the throughput achieved with our previous device designs by over an order of …
The Effect Of Platelet-Rich Plasma (Prp) On Muscle Contusion Healing In A Rat Model., Demetris Delos, Matthew J. Leineweber, Salma Chaudhury, Saif Alzoobaee, Yingxin Gao, Scott Alan Rodeo
The Effect Of Platelet-Rich Plasma (Prp) On Muscle Contusion Healing In A Rat Model., Demetris Delos, Matthew J. Leineweber, Salma Chaudhury, Saif Alzoobaee, Yingxin Gao, Scott Alan Rodeo
Faculty Publications
Background: Current therapy for muscle contusions is usually limited to nonsteroidal anti-inflammatory drugs and/or use of the RICE principle (rest, ice, compression, elevation); thus, other forms of treatment that can potentially accelerate the rate of healing are desirable. Hypotheses: A local injection of platelet-rich plasma (PRP) would lead to accelerated healing rates compared with controls; also, delayed administration of PRP would lead to a blunted response compared with immediate treatment. Study Design: Controlled laboratory study. Methods: Forty-six male Lewis rats each underwent a single blunt, nonpenetrating impact to the gastrocnemius muscle via a drop-mass technique and subsequently received either a …
Averaging Improves Strain Images Of The Biceps Brachii Using Quasi-Static Ultrasound Elastography, Matthew Leineweber, J Westborn, A Cochran, Y Gao, J Choi
Averaging Improves Strain Images Of The Biceps Brachii Using Quasi-Static Ultrasound Elastography, Matthew Leineweber, J Westborn, A Cochran, Y Gao, J Choi
Faculty Publications
OBJECTIVE:Quasi-static ultrasound elastography is a technique for measuring tissue deformation (strain) under externally applied loading and can be used to identify the presence of abnormalities. The objective of this study was to demonstrate the efficacy of averaging strain images from repeated compression cycles in mitigating user-induced error using quasi-static ultrasound elastography.METHODS:Freehand compressions were performed with an ultrasound transducer on the biceps brachii of nine participants (five males and four females), as well as with a custom automated compression system. Sets of strain images from the freehand techniques were averaged to create single representative images and compared against strain images from …