Teacher Education and Professional Development Commons^™

Novel Rpl30 Variant In Diamond Blackfan Anemia Demonstrates Early Impact On Erythroid Differentiation With Downregulated Gata1-Hsp70, Alexandra Prosser-Dombrowski, Irina Pushel, Jacqelyn Nemechek, Priyanka Kumar, Jay L. Vivian, Jennifer Gerton, John M. Perry

Research Days

Background: Diamond Blackfan anemia (DBA) is an inherited bone marrow failure syndrome caused by ribosomal protein gene mutations leading to apoptosis of erythroid progenitors. We identified a novel heterozygous variant (c.167+769C>T) in the noncoding region of RPL30 in a patient diagnosed with DBA.

Objectives/Goal: We hypothesized that this variant stunts erythroid differentiation at the proerythroblast stage and is pathogenic for DBA.

Methods/Design: We developed an induced pluripotent stem cell (iPSC) model with a wild type (WT) and three CRISPR-Cas9 edited RPL30 mutant clones. iPSCs were differentiated into hematopoietic stem cells, which were assessed by flow cytometry and single cell …

Duration Of Labor And Umbilical Artery Acidosis In Critical Congenital Heart Disease, Sarah Gwazdacz Md, Teresa Nguyen Bs, Mary Donofrio Md, Faap, Facc, Fase, Timothy Bennett Md, Amanda Mcintosh Md, Faap, Facc.

Research Days

Standard delivery protocols for most prenatally diagnosed CCHD is induction of labor at 39 weeks with aims of a vaginal delivery (VD) near a tertiary care center. There is no benefit to planned Cesarean delivery (CD) over VD for most infants with CCHD. However, longer durations of labor (DOL) in CCHD have been described as a risk factor for umbilical artery (UA) acidosis. We aim to describe the relationship between DOL and UA pH and neonatal outcomes in those with prenatally diagnosed CCHD.

Retrospective chart review of prenatally diagnosed with CCHD born at Children’s Mercy from 2012 – 2023. Inclusion …

Opportunities For Solid Organ Donation In The Neonatal Intensive Care Unit, Sarah Pippin, Jotishna Sharma, Ashley Sherman, Julie Weiner

Research Days

This study aims to characterize the theoretical eligibility of neonates undergoing withdrawal of care in the NICU for donation after circulatory determination of death (DCDD), with a focus on warm ischemic time (WIT) ≤ 90 minutes.

Abusive Head Trauma (Aht) Diagnoses: The Influence Of Clinical Presentation And Evidence Of Impact, Ruairi Smith-Dewey, Angela N. Bachim, Colleen Bressler, Kristine Campbell, Lori Frasier, Christopher Greeley, Danielle Horton, Nicole Johnson, Jan Leonard, Megan Letson, Daniel M. Lindberg, Caitlin Mcnamara, Shalon Nienow, Ashley K. Sherman, Joanne Wood, James Anderst

Research Days

Background: In cases where Child Abuse Pediatricians (CAPs) diagnose abusive head trauma (AHT) in young children, some factors surrounding the diagnosis have been challenged including causative shaking, necessity of external signs of impact, or concomitant suspicious injuries. Evaluation of CAP diagnoses in children with subdural hemorrhage (SDH) can give insight into factors related to the frequency of abusive head trauma (AHT) diagnoses. Additionally, characterization of those with SDH+CSI without evidence of impact may inform controversies around AHT diagnoses.

Objectives/Goal: We aim to compare CAP diagnoses in subjects with SDH across clinical presentations and in the context of evidence of head …

In Search Of The Unknown Mimic Of Abusive Head Trauma., Ruairi Smith-Dewey, Angela N. Bachim, Colleen Bressler, Kristine Campbell, Lori Frasier, Danielle Horton, Nicole Johnson, Jan Leonard, Megan Letson, Caitlin Mcnamara, Shalon Nienow, Ashley K. Sherman, Stuart Sommers, Joanne Wood, James Anderst

Research Days

Background:

Some claim that Child Abuse Pediatricians (CAPs) are misdiagnosing a yet-to-be-identified mimic as abusive head trauma (AHT), particularly in ill children with isolated subdural hemorrhage (SDH). Though not diagnostic criteria, specific social stressors have been identified as AHT risk factors. If a yet-to-be-identified mimic is meaningfully present within a group being evaluated for AHT, that group should have fewer AHT risk factors than children with actual AHT. The existence of such a mimic can be assessed by comparing the prevalence of AHT risk factors across groups: CAP-identified mimics, non-ill SDH only, ill SDH only, and SDH plus concomitant suspicious …

Engineering A Novel Treg Population To Control Autoimmune Diabetes, Sofia Colon Guzman, Elly Puckett, Mary A. Markiewicz, Ryan T. Fischer

Research Days

We created a model to test the immunosuppressive capacity of Helios+FOXP3+ eTregs compared to nTregs against islet-specific autoreactive T cells. We also showed that nTregs decrease the response of these cytotoxic T cells when co-cultured with BetaLox5 cells.

Growth Hormone Deficiency In Childhood Cancer Survivors: Response To Growth Hormone Therapy And Aromatase Inhibitors Compared To Growth Hormone Therapy Alone., Haya Azouz, Sarah Tsai, Keith August, Jennifer W. Boyd

Research Days

With evolving technologies leading to better cancer cure rate, the number of childhood cancer survivors has increased. There has been increasing reports of later endocrine effects including growth hormone deficiency (GHD). Our aim is to investigate the influence of adding aromatase inhibitors (AI) to growth hormone (GH) therapy in childhood cancer survivors with growth hormone deficiency (GHD). A retrospective chart review was performed looking at children between ages 0 and 18 years with history of malignancy and subsequent diagnosis of GHD at our institution. Fifty-nine children were included in this study. Participants were classified into 3 groups: (1) the target …

Improving Adherence To Evidence Based Sti Care For Patients Who Tested Positive At Ed Index Visit Qi Project, Noelle Tran, Melissa Miller, Kim Barbee, Julie Jost, Christopher Kaberline, M Smith

Research Days

Problem Statement/Question:

Previous work improved clinician sexually transmitted infection (STI) testing behaviors, but overlooked treatment interventions needed to facilitate risk reduction, HIV and syphilis (RPR) testing, and STI retesting at three months—critical components that reduce morbidity and disease spread. We are not adhering to evidence-based STI care for adolescents who tested positive for STIs at the ED index visit.

Background/Project Intent (Aim Statement):

According to the Centers for Disease Control and Prevention (CDC), in 2023, over 2.4 million cases of RPR, gonorrhea (GC), and chlamydia (CT) were diagnosed; about half of reported cases were among adolescents and young adults aged …

Food Insecurity In Adolescent Athletes, Andrew Donaldson, Shannon Margherio, Jay Roberson, Kevin Latz

Research Days

Background: The prevalence of food insecurity among children in the United States is estimated at 21%. Food insecurity during childhood leads to worse school performance, more emotional and behavioral health concerns, and increased suicide attempts. Further, food insecurity has been noted to have multiple deleterious effects on the collegiate student athlete, including lower GPA, disordered eating, and substance use.

Hypothesis: Food insecurity is prevalent in the adolescent athlete population and exists across demographics.

Methods: Voluntary surveys were distributed to parents at all sports medicine clinics at our institution. Demographic data was collected including athlete age, race, school and school district, …

Not All Superheroes Wear Capes: Understanding The Lives Of Asian American Student Caregivers, Angela Ji

Educational Specialist, 2020-current

There exists an invisible army of children who sacrifice their childhoods and shoulder responsibilities expected of adults; these children are called young caregivers. Young caregivers provide significant assistance for their family on a regular basis. The existing literature shows that youth caregiving is associated with negative physical and mental health impacts that vary depending on the cultural background associated with families. It is also clear that the complexities and nuances of different ethnic groups influence the lived experiences of young caregivers. Unfortunately, there is limited information exploring racial and cultural implications of caregiving for children. This study sought to address …

Policy Analysis Of Assessments To Award Seals Of Biliteracy In Spanish In The United States, Lisa J. Harmon-Martínez

Teacher Education, Educational Leadership & Policy ETDs

The Seal of Biliteracy (SoBL) honors high school graduates demonstrating proficiency in two or more languages, yet its policies often perpetuate inequities. Focusing on New Mexico and Spanish language assessments, I explored how the SoBL's recognition of bilingualism intersects with biases against Spanish speakers. While the SoBL aims to celebrate bilingualism, disparities arise from state-to-state variations in assessment requirements, particularly affecting Spanish-speaking students and those receiving English Language Development services. Many states rely on standardized exams that inadequately capture students’ linguistic abilities, exacerbating inequalities. Using an Open Systems policy framework and Translanguaging theory, which values students’ full linguistic repertoires, I …

A Mixed Methods Approach To Understanding Athletic Training Preceptorships Through Measuring Situational Leadership, Jordan R. Dawson

Dissertations, 2020-current

Athletic Training preceptorships play a crucial role in student education as they heavily influence student learning and progression in the academic program (Mazerolle et al., 2015). The problem that arises from preceptorships is the inconsistencies athletic training students experience in leadership. Therefore, the purpose of this study is to investigate athletic training student perceptions of situational leadership as it relates to student satisfaction with the development of a measurement tool. An exploratory mixed methods design composed of a qualitative phase one, pilot testing quantitative phase two, and quantitative phase three. The qualitative phase provided insightful perspectives on preceptor leadership from …

Realizing And Practicing Teaching As A Calling: Narratives From Black Women Teachers In Urban K-12 Public Schools, De'ana Renee Mauldin

UNLV Theses, Dissertations, Professional Papers, and Capstones

Research and scholarship frequently ignore and dismiss the unique experiences and perspectives of Black women teachers. They bring with them a unique angle of vision through various race, gender, cultural, and historical intersections that inform their spirituality-based pedagogy and outlook while providing instruction in urban public schools.The purpose of this qualitative dissertation study is to examine the narratives and amplify the voices of Black women K-12 teachers in urban public schools to address how they realized teaching as a calling. Teaching as a calling is more than simply a job and source of income for these teachers. Understanding of this …

New Teachers’ Mentoring Expectations And Experiences: A Qualitative Multiple Case Study, Preston Maurice Blakely

UNLV Theses, Dissertations, Professional Papers, and Capstones

The purpose of this qualitative multiple case study was to explore how the expectations of new teachers, about their mentoring program and their mentoring experiences can be used to improve the structural design and procedures of mentoring programs to better support new teachers. Socio-historical and sociocultural theories were used to guide the study and purposive sampling strategy was used to recruit five participants who were in the first years of teaching. Based on a rich set of data sources which included a pre-interview and a post- interview, the findings revealed that despite the existence of mentoring programs in the participants’ …

Navigating The Moral Landscape: Courage, Cowardice, And The Educator's Call To Action, Scott H. Sorvaag

Essays in Education

Contemporary educators face an increasingly complex and challenging landscape. This essay explores the vital role of courage and the influence of cowardice in shaping educators' moral leadership and professional practice. By integrating insights from human development reports, leadership theory, and educational philosophy, this essay argues that understanding the internal continuum between courage and cowardice is crucial for educators seeking to create transformative learning environments. The essay provides actionable strategies for fostering courage in daily practice and nurturing partnerships between schools, parents, and communities.

Variation In Blood Culture Testing And Outcomes In Children Hospitalized With Three Common Infections., Smit Shah, Jessica L. Markham, Jennifer Goldman, Matt Hall, Jillian Cotter, Samantha A. House, Matthew J. Molloy, Michelle Polich, Michael J. Steiner, John R. Stephens, Michael J. Tchou, Ronald J. Teufel Ii, Irma Ugalde, Andrew Yu

Research Days

Background: Prior studies of blood culture (BC) testing in uncomplicated community acquired pneumonia (CAP), skin and soft tissue infections (SSTI), and urinary tract infections (UTI) have demonstrated low utility of routine testing given similar rates of pathogen versus contaminant detection and little effect on clinical management. Understanding patterns and outcomes of BC testing can identify opportunities to curb unnecessary testing.

Objectives: The objectives of this study were to: 1) Evaluate BC testing trends over time for children hospitalized for CAP, SSTI, and UTI; and 2) describe differences in clinical outcomes between hospital groups with low, moderate, or high testing rates. …

Association Between Neighborhood Opportunity And Youth Mental Health Emergency Department Visits, Shelby Chesbro Md, Henry T. Puls, Adrienne G. Deporre, Molly Krager, Laura Plencner, Shayla Sullivant, Matthew Hall Phd

Research Days

Background: Youth mental health emergency department visits are increasing and are a burden on the health care system. Prevalence of mental health disorders may be influenced by the neighborhood youths live in.

Objectives/Goal: Determine differences in rates of youth mental health ED visits across zip code levels of neighborhood opportunity.

Methods/Design: We performed a cross-sectional study using the Hospital Industry Data Institute dataset identifying ED visits with a primary mental health diagnosis in Kansas and Missouri for youths aged 5-19 years in 2022-2023. Mental health ED visits were then categorized at the zip code level by neighborhood opportunity using the …

Reducing Vancomycin Use In The Cicu, Karoline Krzywda, Ali Taber, Lauren Johnson

Research Days

Background/Aim Statement: In the CICU empiric vancomycin is frequently prescribed. This practice occurs without broad knowledge of the actual rates of methicillin resistant staph aureus (MRSA) and methicillin resistant staph epidermidis (MRSE) infections. Given the potential for harmful side effects of vancomycin as well as concern for growing antibiotic resistance, we sought to better characterize local unit prescribing practices and MRSA/MRSE infection rates to guide our QI project with an aim of reducing vancomycin use in the CICU.

Methods (include PDSA cycles): Patient data from January 2021 to January 2023 was analyzed. The number of monthly days spent on vancomycin …

A Risk Score To Predict Recurrent High Intensity Inpatient Resource Utilization For Children With Medical Complexity., Charles Maloy, Matthew Hall, Jessica L. Bettenhausen, Yui-Yee Chan, Leah Jones, Kathryn Kyler, Laura Plencner Md, Jessica Markham, Jacqueline M. Walker, Smit Shah, Sîan Best, Jonathan Ermer, Shelby Chesbro, Maria Newmaster, Henry T. Puls

Research Days

Background: Children with medical complexity (CMC) use a greater amount of inpatient resources and stand to benefit from unique care models and coordination. However, hospital resources can be limited, and a better understanding of which CMC are high resource users could improve hospital and staff planning.

Objectives/Goal: To develop a risk score predictive of recurrent high intensity inpatient utilization among CMC.

Methods/Design: We conducted a retrospective cohort study of children <18 years old with ≥3 complex chronic conditions (CCC) discharged from one of 48 children’s hospitals in the Pediatric Health Information System during 2021 and 2022. To reflect CMC typically cared for by a general medical service, children with cardiac procedures, dialysis, oncology, or transplant CCCs, and index hospitalization mortality were excluded. We used multivariable logistic regression to determine factors present on the index hospitalization associated with ≥5 hospitalizations or ≥3 hospitalizations with one lasting ≥25 days within any 365-day period (high inpatient utilization) in 2021-2023. We developed risk scoring system using model coefficients and defined the optimal risk score cutoff to maximize sensitivity and specificity. We then applied the risk score cutoff to children discharged to determine (a) ratio of predicted:actual CMC with recurrent high resource use and (b) the total predicted daily volume on 50th, 75th, and 90th percentile days for each hospital.

Results: Of 44,432 included children, 9,596 (21.6%) had high inpatient utilization (Table). Children under 1 year of age had the highest odds of high inpatient utilization (OR 2.26 [95% CI: …

Failure To Launch: Pediatric Colorectal Surgery Center Utilization By Patients Over 18 Years Of Age, Vatche Melkonian, Andres Gonzalez Salazar, Cory Nonnemacher, Seth Saylors, Margaret Martin-Mclain, Iris Lim-Beutel, Rebecca Rentea

Research Days

Background: As patients with childhood colorectal diseases transition into adulthood, many continue to seek care at pediatric colorectal centers rather than transitioning to adult hospital systems. This preference often stems from a sense of comfort and familiarity with their pediatric care teams. Additionally, patients often perceive inadequacies in adult healthcare systems in managing their specific conditions. As these numbers of patients continue to grow, pediatric colorectal centers may face increasing demands on their resources, potentially diverting attention away from pediatric patients.

Objectives/Goal: The objective of this study was to assess the utilization of our pediatric colorectal center by patients aged …

Patterns And Growth Of A Dedicated Pediatric Coagulation Consult Service In A Freestanding Children's Hospital, Nicole Demarco, Shannon Carpenter, Brian Lee

Research Days

Background: Hospital-acquired thrombosis remains a significant concern in pediatric care, contributing to morbidity and extended hospital stays. At Children’s Mercy, a dedicated inpatient coagulation consultation service has existed for many years. Efforts have been made to implement prophylactic measures aimed at reducing the incidence of hospital-acquired thrombosis. With the recent COVID pandemic we saw an influx in prophylactic anticoagulation due to recommended guidelines.

Objectives: To characterize the impact increased efforts in thromboprophylaxis during and after the COVID-19 pandemic on care delivery and the development of thrombosis among pediatric hospitalized patients.

Methods: This retrospective review included all pediatric inpatients with a …

Multi-Omic Analysis Of Kmt2a-Rearranged Pediatric Acute Myeloid Leukemia Reveals Novel Pathways Of Interest, Trenton Edwards, Irina Pushel, Thomas Gremminger, Lisa Lansdon, Byunggil Yoo, Michaella Rekowski, Michael Washburn, Midhat Farooqi

Research Days

Objectives/Goals

Acute Myeloid Leukemia (AML) is the second most common leukemia among pediatric populations. Approximately 15% of pediatric AML cases have KMT2A gene rearrangements (KMT2A-r), which carry a worse prognosis. Our goal is to better characterize the biologic landscape of KMT2A-r pediatric AML. We hypothesize that a multi-omic approach will reveal mechanisms underlying the aggressive nature of KMT2A-r AML.

Methods/Study Population

This study makes use of deidentified peripheral blood and/or bone marrow samples banked in the Children’s Mercy Tumor Bank Biorepository. For this study, we used samples at diagnosis and remission from four KMT2A-r pediatric AML …

No Suspicion For Nocarh: A Cautionary Tale Of Anchoring Bias, Nicole Demarco, Shannon Haines, Julia Allyson Hays, Bonnie Sullivan, Michael Price, Kimberly A. Horii

Research Days

Neonatal onset of cytopenia autoinflammation rash and hemophagocytic lymphohistiocytosis syndrome (NOCARH), a subset of hemophagocytic lymphohistiocytosis (HLH), is a rare and life-threatening condition characterized by uncontrolled immune response. It presents a diagnostic challenge in neonates due to the overlap of clinical features with other conditions, particularly congenital infections.

Nrp And Pals In Icu Code Events At A Quaternary Care Pediatric Hospital: A ‘Compressed’ Analysis, Deepa Kumar, Mitch Kinkor, Stephen Pfeiffer, Allison Taber, Janelle R. Noel-Macdonnell Phd, Jessica Brunkhorst, Danielle Reed

Research Days

This is a retrospective observational study comparing code events in children less than 18 months of age who were resuscitated in the NICU, PICU, and CICU using neonatal resuscitation program (NRP) and pediatric advance life support (PALS).

Being In Community With Children And Engaging Their Full Range Of Civic Capabilities. A Response To "Learning To Talk And Listen In Elementary Social Studies: Exploring A Third-Grade Teacher’S Decision To Use Classroom Talk For Community Building", Katherina A. Payne

Democracy & Education

Early childhood social studies should open opportunities for children to make sense of their social world; the civic question of how we live together is central to the social world. Elementary classrooms are uniquely positioned to support democratic civic education given the amount of time children and adults spend together, the emphasis placed on cultivating a positive classroom community, and children’s capabilities to cultivate relationships full of care and concern for people from outside their close familial relations. In response to Lo’s (2025) examination of a third-grade teacher’s use of discussion to engage in contentious topics while cultivating a sense …

Toward Discussion Facilitation That Enacts Collective Care. A Response To “Teaching Dobbs Where Divisive Concepts And Abortion Are Restricted”, Jenni Conrad

Democracy & Education

For both teacher candidates and teacher educators, facilitating discussions of contested issues in hyper-polarized climates remains a heavy lift. This response to “Teaching Dobbs…” celebrates the successes apparent in Geller’s team’s work and identifies key features that supported it. While cautioning readers against adopting avatar rehearsals elsewhere, I distill four themes of planning and enactment that show clear promise for broad transference in teacher education. Drawing from research exploring the interfaces of justice-oriented, practice-based, and democratic social studies scholarship, I offer pedagogical and logistical considerations for other teacher educators and researchers engaged in this ambitious and necessary work to sustain …

Teaching Dobbs Where Divisive Concepts And Abortion Are Restricted: Teacher Learning, Controversial Issues, And Mixed-Reality Technology, Rebecca C. Geller

Democracy & Education

Though scholarship has long championed the positive impacts of classroom considerations of controversial or difficult issues, teachers have often hesitated to broach divisive topics for numerous reasons, including legislation purporting to limit controversy in classrooms and, often, that they had limited or no preparation to teach controversies, especially not politically contentious sociopolitical contexts. I worked with a research team to use a mixed-reality teaching simulation of a controversial issue discussion as a low-stakes learning context for developing skills for collective pedagogical reasoning. The teaching simulation centered on Dobbs v. Jackson, the 2022 Supreme Court decision that overturned Roe v. …

Joy In Lifelong Learning: An Introduction To Planning For Learning Disabilities In Museum Education, Elaine L. Davis

Seton Hall University Dissertations and Theses (ETDs)

For over a century, the role of museums as learning institutions has been considered alongside that of schools. However, special education practices are rarely adapted for museum education, requiring educators in museum contexts to undertake extra work to accommodate those with learning disabilities. This thesis used Qualitative Comparative Analysis and Textual Analysis to review pedagogical white papers and academic research on museum programs aimed at neurodivergent audiences. The findings were used to create a professional development guide for museum educators at a range of different types of museums.

Data In The Classroom: The Impact Of A Data-Centric, High School Program To Motivate Career Interest In Stem Fields, Tyler Stabiler

Theses and Dissertations

This dissertation proposes to analyze the importance of introducing data-centric STEM (Science, Technology, Engineering, and Mathematics) studies at the high school level. In today's digital age, the importance of studying data-centric STEM in high school cannot be overstated. This dissertation looks to discover educational capabilities of high school students in various grade levels by understanding their drive, desire, and ambitions in a different STEM course than what is currently offered at the high school. Finally, the study analyzes the students’ participation in lectures, laboratory environment, and model/simulations to identify the significance in high schools adding data-centric curriculums to their academic …

The Impact Of Race-Corrected Spirometry Results On Eligibility Into An Asthma Clinical Trial, Carina H. Perdew, Bridgette L. Jones, Wumi V. Akinjole

Research Days

BACKGROUND: Spirometry is a widely used pulmonary function test that assesses lung function by examining airflow and capacity. Spirometry measurements assist in the diagnosis, severity classification, and management of asthma, and can affect one’s eligibility into various events (e.g., clinical trials, high-risk jobs, sports). Reference equations are used to establish predicted values to account for biological variables such as age, sex, and height; however past clinical guidelines recommended utilizing race-correction. The incorporation of race may negatively impact people of color due to misrepresentation of one's lung function, consequently impacting future medical management. OBJECTIVES: To characterize differences in spirometry values across …