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Body Mass-Normalized Moderate Dose Of Dietary Nitrate Intake Improves Endothelial Function And Walking Capacity In Patients With Peripheral Artery Disease, Elizabeth J. Pekas, Tesean Wooden, Santosh K. Yadav, Song-Young Park

Health and Kinesiology Faculty Publications

Peripheral artery disease (PAD) is characterized by the accumulation of atherosclerotic plaques in the lower extremity conduit arteries, which impairs blood flow and walking capacity. Dietary nitrate has been used to reduce blood pressure (BP) and improve walking capacity in PAD. However, a standardized dose for PAD has not been determined. Therefore, we sought to determine the effects of a body mass-normalized moderate dose of nitrate (0.11 mmol nitrate/kg) as beetroot juice on serum nitrate/nitrite, vascular function, walking capacity, and tissue oxygen utilization capacity in patients with PAD. A total of 11 patients with PAD received either nitrate supplement or …