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Dynamic Modeling Of Fluid Flow Within Three-Dimensional Perfusion Bioreactor, Zulikayida Maimaiti, Max J. Lerman, Bs, John P. Fisher, Phd, Jesse K. Placone, Phd

Journal of Health Disparities Research and Practice

Three-dimensional perfusion bioreactors have been shown to enhance cell viability and function through improved nutrient exchange. However, the ideal bioreactor scaffold geometry is still unknown. The focus of this study is to use computational fluid flow studies to inform bioreactor design. Specifically, we will model the effect of bioreactor design on fluid shear stress and then correlate these values with stem cell viability in the bioreactor. Previous studies have shown that the maximum shear stress level for the viability of human mesenchymal stem cells (hMSCs) is 0.3 dynes/cm². Two distinct Computer Aided Design models were created consisting of …