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Oncolog, Volume 61, Number 05, May 2016, Bryan Tutt, Katelyn Werner

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Intratumoral Therapies Offer Novel Cancer Treatment Approach: Injecting cancer treatments such as vaccines and genetically modified bacteria and viruses directly into tumors may shrink or destroy the tumors and stimulate an immune response that attacks tumor cells. These treatments have shown promise in clinical trials, and newer trials are exploring whether such treatments can augment the effectiveness of immunotherapy in patients with metastatic or inoperable disease.
• High-Risk Acute Lymphoblastic Leukemia Subtype Targeted in Upcoming Clinical Trial: Early T cell precursor acute lymphoblastic leukemia (ETP-ALL), an uncommon subtype of T cell acute lymphoblastic leukemia (T-ALL), carries a poor prognosis and low …

Oncolog, Volume 61, Number 04, April 2016, Joe Munch, Bryan Tutt, K Werner

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Aggressive Multimodality Salvage Therapy for Locally Recurrent Rectal Cancer Offers Hope to Patients: For patients with locally recurrent rectal cancer, multimodality salvage therapy presents the only chance for a cure. Such therapy is offered at just a handful of specialized referral institutions, including The University of Texas MD Anderson Cancer Center.
• Rapid Assessment, Clinical Trials Could Improve Outcomes for Anaplastic Thyroid Cancer Patients: Anaplastic thyroid cancer is extremely aggressive-only 20% of patients survive 1 year after their diagnosis-so patients require immediate assessment and treatment. A program at The University of Texas MD Anderson Cancer Center expedites the care of patients …

Emil Zuckerkandl, M.D. (1849-1910): Bridging Anatomic Study And The Operating Room Table., Leah Winer, Md, Pankhuri Jha, Scott W. Cowan, Md, Charles J. Yeo, Md, Scott D. Goldstein, Md

Department of Surgery Gibbon Society Historical Profiles

In the mid-19th century, the Vienna School of Anatomy was at the epicenter of the rapidly growing field of anatomy. One of the school’s most distinguished professors, Hungarian-born anatomist Emil Zuckerkandl was instrumental in transforming anatomy from a descriptive science to one of practical and clinical value. A prolific researcher interested in nearly all areas of morphology and most famously, the chromaffin system, Zuckerkandl’s discoveries from more than a century ago still provide a foundation for surgeons to this day.

Oncolog, Volume 61, Number 03, March 2016, Bryan Tutt, Sarah Bronson, Jill Delsigne, K Werner

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Innovations Decrease Toxic Effects of Radiation Therapy for Mediastinal Tumors from Hematological Malignancies: Anterior mediastinal masses caused by lymphoma or leukemia can be difficult to treat because sensitive tissues in the area are vulnerable to damage from radiation therapy. To treat these tumors while sparing healthy tissue, radiation oncologists at The University of Texas MD Anderson Cancer Center use a combination of advanced technologies and new techniques.
• Transoral Robotic Surgery Enables Less Toxic Treatment of Early Throat Cancers: For decades, many patients with hard-to-reach throat cancers received high-dose radiation and chemotherapy, with their often severe toxic effects, because conventional surgery …

Oncolog, Volume 61, Number 02, February 2016, Joe Munch, Bryan Tutt, C Graber

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Overcoming Challenges in Cutaneous T Cell Lymphomas: Cutaneous T Cell lymphomas (CTCLs) not only are largely incurable but also make patients miserable with itching, burning skin and unsightly lesions. Because CTCL can resemble various benign skin conditions, many patients are diagnosed at an advanced and difficult-to-treat stage. But ongoing clinical trials may offer patients with CTCL improved treatments and better quality of life.
• Swallowing Therapy Improves Function and Quality of Life for Patients with Head and Neck Cancer: In patients with head and neck cancer, loss of swallowing function may result from radiation therapy, surgery, or the cancer itself and …

January 2016, New England Osteopathic Heritage Center

New England Osteopathic Heritage Center Newsletter

Annual newsletter created by the New England Osteopathic Heritage Center in January 2016.

A Dramaturgical Analysis Of The Miracle Worker, Abby Butzer

All Graduate Theses, Dissertations, and Other Capstone Projects

This document is a thesis submitted in partial fulfillment of the Master of Arts degree in theatre. It is a dramaturgical analysis for William Gibson's play The Miracle Worker, providing a reference for directors and actors. The thesis explores the play's medical and pedagogical history in six chapters: the physiology and psychology of language acquisition as it pertains to sight and/or hearing impaired children, a pedagogical comparison of Samuel G. Howe and Annie Sullivan, a modern diagnosis of the fever that destroyed Helen Keller's vision and hearing, the 19th century pathology and treatment options for the disease of the eye …

Oncolog, Volume 61, Number 01, January 2016, Sarah Bronson, Bryan Tutt, Bryan Tutt

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Proactive Management of Li-Fraumeni Syndrome Benefits Patients: Li-Fraumeni syndromes a hereditary disorder that confers an extremely high likelihood of developing cancer on affected individuals.
• Clinical Trial Tests High-Dose Radiation Therapy for Limited Stage Small Cell Lung Cancer: Small cell lung cancer carries a poor prognosis, even for patients without metastatic disease. But a phase III trial of high-dose daily or accelerated twice-daily thoracic radiation therapy for limited stage small cell kung cancer may lead to longer survival.
• Reducing Complications and Hospital Readmissions after Liver Surgery: Hepatectomy carries a risk of complications that can lead to hospital readmission and even death. …

The Creation Of A Model Pediatric Ward For African American Children In 1920s Kansas City., Jane F. Knapp, Robert Schremmer

Manuscripts, Articles, Book Chapters and Other Papers

No abstract provided.

Carmen Pettapiece, D.O. Scrapbook 5, Carmen Pettapiece D.O.

Carmen Pettapiece, D.O. Scrapbooks

Scrapbook of personal papers and osteopathy-related materials from the collection of Carmen Pettapiece, D.O.

Carmen Pettapiece, D.O. Scrapbook 4, Carmen Pettapiece D.O.

Carmen Pettapiece, D.O. Scrapbooks

Scrapbook of personal papers and osteopathy-related materials from the collection of Carmen Pettapiece, D.O.

Oncolog, Volume 60, Number 11 - 12, November - December 2015, Joe Munch, Bryan Tutt, C. Graber

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Multidisciplinary Treatment Maximizes Outcomes for malignant Tumors of the Anterior Skull Base: Malignant tumors of the anterior skull base occur in a delicate area but often need aggressive treatment. Determining the best course of therapy for patients with these tumors takes a multidisciplinary effort.
• Management of Eyelid and Conjunctival Tumors with Preservation of Slight, Function and Cosmesis: Tumors of the eyelid and extent of disease, and which treatments, if any, are needed after surgical excision depends on several factors, including the potential for metastasis.
• HOUSE CALL: "Other" Health Risks from Smoking-Besides cancer, tobacco causes many diseases.

Oncolog, Volume 60, Number 10, October 2015, Joe Munch, Bryan Tutt, Jill Delsigne, K. Nair

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• New Targeted Therapy Offers Hope to Patients with Blastic Plasmacytoid Dendritic Cell Neoplasm, Related Diseases: The treatment of common hematological malignancies is based on reams of study data and years of physician experience with the diseases. But such information is often limited for rare, little-researched blood cancers like blastic plasmacytoid dendritic cell neoplasm (BPDCN). This situation may soon change, thanks to the discovery of a new molecular target, which has led to a spate of innovative treatment approaches and the first dedicated clinical trials for this uncommon malignancy.
• Laparoscopic Free Omental Lymphatic Flap Transfers Offer a Powerful Alternative for Lymphedema …

Oncolog, Volume 60, Number 09, September 2015, Sarah Bronson, Bryan Tutt, K. Nair

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Enhanced Surgical Recovery Programs Improve Perioperative Outcomes for Cancer Patients: For patients undergoing cancer surgery, potential complications and long recovery times can delay the delivery of additional life-saving therapy. To improve patients' perioperative outcomes and clear the way for timely administration of additional therapies, several surgical teams at The University of Texas MD Anderson Cancer Center gave begun using enhanced surgical recovery programs (ESRPs).
• New Treatments for Respiratory Viruses in Immunocompromised Patients: Viral respiratory infections are a major concern for immunocompromised patients, in whom such infections are difficult to treat and can lead to pneumonia and even death. Although few …

Oncolog, Volume 60, Number 08, August 2015, Stephanie Deming, Bryan Tutt, K. Nair

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• New Gene Therapy for Bladder Cancer Shows Promise: A gene therapy that stimulates interferon production within the body may prove to be effective against high-risk, early-stage bladder cancer when standard treatment fails.
• Vaccine Helps T Cells Target Sarcomas, Melanomas and other Tumors: A vaccine that delivers an antigen to dendritic cells, in turn activating killer T cells that can target specific cancers, is the subject of two ongoing clinical trials,
• INBRIEF: Glypican-1 Shows Promise as a Biomarker for Pancreatic Cancer/Stereotactic Ablative Radiation Therapy for Stage I Non-Small Cell Lung Cancer May Offer Survival Benefit
• HOUSE CALL: Prostate Cancer Screening-Who should …

Carmen Pettapiece, D.O. Scrapbook 3, Carmen Pettapiece D.O.

Carmen Pettapiece, D.O. Scrapbooks

Scrapbook of personal papers and osteopathy-related materials from the collection of Carmen Pettapiece, D.O.

Oncolog, Volume 60, Number 07, July 2015, Kathryn L. Hale, Bryan Tutt, K. Stuyck

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Emergency Care for Cancer Patients: Medical problems that may seem routine in patients without cancer often mean something different or have a different cause in cancer patients and may be much more serious, requiring urgent treatment. Managing these problems promptly and effectively is a challenge faced by all cancer centers.
• Immunotherapy Trials Offer Hope to Patients with High-Risk or Metastatic Cancer: Although the cure rate for the breast cancer has risen steadily in recent decades, recurrent or metastatic disease remains difficult to control. To fight metastatic breast cancer and forestall the recurrence of high-risk primary disease, researchers at The University …

Alton Ochsner, Md (1896-1981): Surgical Pioneer And Legacy Linking Smoking And Disease., Christina L. Costantino, Md, Jordan M. Winter, Md, Charles J. Yeo, Md, Scott W. Cowan, Md

Department of Surgery Gibbon Society Historical Profiles

Edward William Alton Ochsner kept a plain, metal card file in which he recorded close to 50 years worth of medical experiences, research, and insights. The most populated topics were filed as "Cancer, Lung" and "Cancer, Bronchogenic." These reflected his areas of greatest interest, for which he would go on to produce groundbreaking work. Of his many lifetime accomplishments, he is perhaps best known for being the first to report a link between cigarette smoking and lung cancer. This was just one of the many ways in which Ochsner worked to effect social change. The establishment of the Ochsner Health …

Oncolog, Volume 60, Number 06, June 2015, Bryan Tutt, Joe Munch, U. Arizor

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• New Breast Imaging Modalities Show promise for Cancer Screening and Staging: New technology to supplement digital mammography may improve breast cancer screening and diagnosis. Although some of these new imaging modalities are still under development, others are already in clinical use as adjuncts to mammography for breast cancer screening and staging.
• Addressing Sexual Dysfunction in Cancer Survivors: Cancer treatments carry a host of side effects that can affect patients' ability to have and enjoy sex. The sexual dysfunction arising from these side effects, which include functional changes, can often be addressed, but uncovering sexual dysfunction can prove challenging.
• HOUSE CALL: …

The Medical Response To The Black Death, Joseph A. Legan

Senior Honors Projects, 2010-2019

This paper discusses the medical response to the Black Death in both Europe and the Middle East. The Black Death was caused by a series of bacterial strands collectively known as Yersinia pestis. The Plague originated in the Mongolian Steppes. It was spread westward by the east-west trading system. Once it arrived in the Crimea in 1346, Italian merchants helped spread it throughout the Mediterranean. Medicine in Europe and the Middle East were centered on Galen’s theory of humors. There were many religious explanations for the Plague, but the main medical explanation was the spread of bad air, or …

Frederic E. Mohs, M.D. (1910-2002): Physician And Innovator., Nicholas A. Ross, B.A., Nazanin Saedi, Md, Charles J. Yeo, Md, Scott W. Cowan, Md

Department of Surgery Gibbon Society Historical Profiles

Frederic “Fred” E. Mohs was an “honest and good man, a ferocious and courageous worker.”1 Husband, father of three, prolific writer, and speaker, Dr. Mohs was a pioneer in many fields. His desire to do good was fueled by his enthusiasm for scientific advancement (Frederic E. Mohs Jr., personal communication, 2014). He is most remembered for Mohs Micrographic Surgery, formerly chemosurgery, which allows visualization and examination of all tissue margins achieving skin cancer cure rates of 98 to 99 per cent.

Oncolog, Volume 60, Number 05, May 2015, Sarah Bronson, Bryan Tutt, U. Arizor

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Algorithm for Treating Advanced Ovarian Cancer Increases Complete Resection Rate: Most ovarian cancers have spread beyond the ovary by the time they are diagnosed, and they often recur even after responding to primary treatment. Researchers at The University of Texas MD Anderson Cancer Center aim to improve patient outcomes by changing the standard approach to newly diagnosed advanced ovarian cancer.
• Clinical Trials Explore Systemic Treatments for Brain Metastases from Breast Cancer: Brain metastases from breast cancer are difficult to treat because many of the systemic drugs that are effective against breast cancer cannot cross the blood-brain barrier. But researchers at …

Oncolog, Volume 60, Number 04, April 2015, Jill Delsigne, Joe Munch, Bryan Tutt, Sarah Bronson

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Multidisciplinary Globe-Sparing Treatment for Lacrimal Gland Carcinoma Preserves Vision and Minimizes Morbidity: Until recently, the treatment of lacrimal gland carcinoma almost always required removal of the eye. But for some patients with these tumors, globe-sparing surgery followed by radiation therapy can preserve vision and decrease ocular morbidity and facial disfigurement.
• Novel Trial Design Streamlines Development of Breast Cancer Therapies: Developing a cancer-fighting drug can take around a billion dollars and a dozen or more years. Even then, fail in clinical trials. To identify effective cancer therapies more quickly and efficiently, researchers have tuned to an innovative clinical model in which …

Oncolog, Volume 60, Number 03, March 2015, Bryan Tutt, Kathryn L. Hale, K. Stuyck

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Small Cell Lung Cancer Studies May Increase Treatment Options: Despite advances in treating many cancers, the standard treatment of small cell lung cancer has remained unchanged for decades. But researchers at The University of Texas MD Anderson Cancer Center are exploring several new approaches to treat small cell lung cancer.
• Improved Maintenance Therapy Promotes Myeloma patients' Quality of Life After Stem Cell Transplantation: High-dose chemotherapy followed by autologous stem cell transplantation can prolong survival for patients with multiple myeloma. However, patients remain at a high risk of relapse even after transplantation. Maintenance therapy can extend remission in these patients, and …

Francis Daniels Moore: One Of The Brightest Minds In The Surgical Field., Sara L. Low, Bs, Charles J. Yeo, Md, Scott W. Cowan, Md, Ashesh P. Shah, Md

Department of Surgery Gibbon Society Historical Profiles

Francis Daniels Moore was a pioneer ahead of his time who made numerous landmark contributions to the field of surgery, including the understanding of metabolic physiology during surgery, liver and kidney transplant, and the famous Study on Surgical Services of the United States (SOSSUS) report of 1975 that served for decades as a guideline for development of surgical residencies. He was the epitome of what a physician should be, a compassionate and dedicated surgeon, innovative scientist, and a medical professional dedicated to quality medical education across all specialties.

Vivien Thomas: Master Craftsman, Gifted Teacher, And Unsung Hero., Alisha Joyner, B.S., Charles J. Yeo, Md, Pinckney J. Maxwell, Iv, Md

Department of Surgery Gibbon Society Historical Profiles

The field of pediatric cardiovascular surgery gained international recognition in 1944 with the first successful correction of a tetralogy of Fallot congenital anomaly in a 15-month-old patient. Dr. Helen Taussig (1898 to 1986), a pediatrician at Johns Hopkins Hospital, recognized the need for the procedure. Dr. Alfred Blalock (1899 to 1964), Chief of Surgery at Johns Hopkins Hospital, is credited with performing the surgery. However, there is an unsung hero who for many years did not receive a single mention in the medical literature. Vivien Thomas (1910 to 1985) was Dr. Blalock’s research assistant who is said to have stood …

Oncolog, Volume 60, Number 02, February 2015, Sarah Bronson, Bryan Tutt, N. Danckers

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Natural Killer Cell Therapy May Augment Treatment of Hematological Cancers: Tough cancer treatments can severely weaken the body's natural ability to attack cancer cells. To improve immune recovery and function in patients who have undergone these treatments, especially those who may later receive a stem cell transplant, researchers are turning to natural killer cells that have been expanded in the laboratory.
• Concurrent Treatment of HIV and Cancer Improves Survival Outcomes: Concurrent HIV and cancer present special challenges in the clinic, regardless of which disease is diagnosed first. The simultaneous treatment of HIV and cancer is complicated by patients' weakened immune …

Dr. Mary Edwards Walker: Years Ahead Of Her Time., Dre M. Irizarry, Bs, Nicole Salomone, As, Karen A. Chojnacki, Md, Charles J. Yeo, Md, Scott W. Cowan, Md, Linda J. Bogar, Md

Department of Surgery Gibbon Society Historical Profiles

Women phsycians in the United States were virtually nonexistent in the early to mid-1800s. Traditional medical schools still did not accept women, and few secretarian or eclectic medical schools were beginning to open their doors to female students. In 1849 at Geneva College, Elizabeth Blackwell became the first woman to achieve a medical degree in the United States.1 At the time of the Civil War, the few women who had managed to obtain medical degrees mainly served as nurses in the war, because society was not yet ready to accept the female physician.2 Dr. Mary Edwards Walker would help change …

Oncolog, Volume 60, Number 01, January 2015, Bryan Tutt, Markeda Wade, Bryan Tutt, N. Danckers

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Simultaneous Resection of Liver and Lung Metastases from Colorectal Cancer Eliminates Need for Second Surgery: Patients with colorectal cancer metastases to the liver and one or both lungs often face the unwelcome prospect of two operations and two recovery periods. But a novel surgical approach enables the liver and lung lesion resections to be performed during the same operation.
• Some Breast Cancer Patients May Benefit from Shorter Course of Whole-Breast Irradiation: A shorter course of radiation therapy at higher doses per fraction than the standard regimen could reduce side effects and improve quality of life for some patients with breast …

Robert Edward Gross (1905-1988): Ligation Of A Patent Ductus Arteriosus And The Birth Of A Specialty., Alexander V. Chalphin, Bs, Charles J. Yeo, Md, Scott W. Cowan, Md, Stacey Milan, Md

Department of Surgery Gibbon Society Historical Profiles

The early 20th century saw an explosion in surgical expertise. Specialties dedicated to delicate organs such as the heart and vulnerable populations, like children, were in their infancy. Dr. William E. Ladd, the father of pediatric surgery, founded the first dedicated department of pediatric surgery at Boston Children’s Hospital in 1910. At the time, attempts at cardiac surgery almost universally ended in death of the patient. The first successful surgical treatment of the cardiac valves would not occur for another 15 years, and the great vessels would remain out of reach for decades more. Dr. Robert E. Gross, the shy …