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Erratum: Correction To: Characteristics Of Therapeutic Alliance In Musculoskeletal Physiotherapy And Occupational Therapy Practice: A Scoping Review Of The Literature (Bmc Health Services Research (2017) 17 1 (375)), Folarin Babatunde, Joy Macdermid, Norma Macintyre
Erratum: Correction To: Characteristics Of Therapeutic Alliance In Musculoskeletal Physiotherapy And Occupational Therapy Practice: A Scoping Review Of The Literature (Bmc Health Services Research (2017) 17 1 (375)), Folarin Babatunde, Joy Macdermid, Norma Macintyre
Bone and Joint Institute
CORRECTION: Following publication of the original article [1], an erratum was initiated in order to include supplementary material that was not updated and not included during the online submission of the authors' corrections. The additional corrections, included below, are to Appendix II. The original article has been corrected.
Determination Of Knee Cartilage Volume And Surface Area In Beagle Dogs: A Pilot Study, Aad Dhollander, Amanda Malone, James Price, Alan Getgood
Determination Of Knee Cartilage Volume And Surface Area In Beagle Dogs: A Pilot Study, Aad Dhollander, Amanda Malone, James Price, Alan Getgood
Bone and Joint Institute
© 2017, The Author(s). Background: The objective of this study was to determine the cartilage volume and surface area of male and female Beagle dog knees using 3D (3 dimensional) reconstructed MRI images. Methods: Six Beagle Dogs (Canis familiaris) (3 males and 3 females) of 10-18 months old and weighing between 7.2 and 17.1 kg underwent a MRI evaluation of both knees. The data acquired allowed a 3D reconstruction of the knee and measurement of the cartilage volume and surface area. Results: Mean knee cartilage volume (averaged over the right and left knees) of animals between 7.2 and 17.1 kg …
Assessment Of Embedded Conjugated Polymer Sensor Arrays For Potential Load Transmission Measurement In Orthopaedic Implants, Carolina Micolini, Frederick Benjamin Holness, James A. Johnson, Aaron David Price
Assessment Of Embedded Conjugated Polymer Sensor Arrays For Potential Load Transmission Measurement In Orthopaedic Implants, Carolina Micolini, Frederick Benjamin Holness, James A. Johnson, Aaron David Price
Bone and Joint Institute
© 2017 by the authors. Licensee MDPI, Basel, Switzerland. Load transfer through orthopaedic joint implants is poorly understood. The longer-term outcomes of these implants are just starting to be studied, making it imperative to monitor contact loads across the entire joint implant interface to elucidate the force transmission and distribution mechanisms exhibited by these implants in service. This study proposes and demonstrates the design, implementation, and characterization of a 3D-printed smart polymer sensor array using conductive polyaniline (PANI) structures embedded within a polymeric parent phase. The piezoresistive characteristics of PANI were investigated to characterize the sensing behaviour inherent to these …
Ventilation Inhibits Sympathetic Action Potential Recruitment Even During Severe Chemoreflex Stress, Mark B. Badrov, Otto F. Barak, Tanja Mijacika, Leena N. Shoemaker, Lindsay J. Borrell, Mihajlo Lojpur, Ivan Drvis, Zeljko Dujic, J. Kevin Shoemaker
Ventilation Inhibits Sympathetic Action Potential Recruitment Even During Severe Chemoreflex Stress, Mark B. Badrov, Otto F. Barak, Tanja Mijacika, Leena N. Shoemaker, Lindsay J. Borrell, Mihajlo Lojpur, Ivan Drvis, Zeljko Dujic, J. Kevin Shoemaker
Bone and Joint Institute
© 2017 the American Physiological Society. This study investigated the influence of ventilation on sympathetic action potential (AP) discharge patterns during varying levels of high chemoreflex stress. In seven trained breath-hold divers (age 33 ± 12 yr), we measured muscle sympathetic nerve activity (MSNA) at baseline, during preparatory rebreathing (RBR), and during 1) functional residual capacity apnea (FRCApnea) and 2) continued RBR. Data from RBR were analyzed at matched (i.e., to FRCApnea) hemoglobin saturation (HbSat) levels (RBRMatched) or more severe levels (RBREnd). A third protocol compared alternating periods (30 s) of FRC and RBR (FRC-RBRALT). Subjects continued each protocol until …
Determining The Impact Of A New Physiotherapist-Led Primary Care Model For Back Pain: Protocol For A Pilot Cluster Randomized Controlled Trial, Jordan Miller, David Barber, Catherine Donnelly, Simon French, Michael Green, Jonathan Hill, Joy Macdermid, Jacquelyn Marsh, Kathleen Norman, Julie Richardson, Monica Taljaard, Timothy Wideman, Lynn Cooper, Colleen Mcphee
Determining The Impact Of A New Physiotherapist-Led Primary Care Model For Back Pain: Protocol For A Pilot Cluster Randomized Controlled Trial, Jordan Miller, David Barber, Catherine Donnelly, Simon French, Michael Green, Jonathan Hill, Joy Macdermid, Jacquelyn Marsh, Kathleen Norman, Julie Richardson, Monica Taljaard, Timothy Wideman, Lynn Cooper, Colleen Mcphee
Bone and Joint Institute
© 2017 The Author(s). Background: Back pain is a leading contributor to disability, healthcare costs, and lost work. Family physicians are the most common first point of contact in the healthcare system for people with back pain, but physiotherapists (PTs) may be able to support the primary care team through evidence-based primary care. A cluster randomized trial is needed to determine the clinical, health system, and societal impact of a primary care model that integrates physiotherapists at the first visit for people with back pain. Prior to conducting a future fully powered cluster randomized trial, we need to demonstrate feasibility …
High Rates Of Return To Sports Activities And Work After Osteotomies Around The Knee: A Systematic Review And Meta-Analysis, Alexander Hoorntje, Suzanne Witjes, P. Paul F.M. Kuijer, Koen L.M. Koenraadt, Rutger C.I. Van Geenen, Joost G. Daams, Alan Getgood, Gino M.M.J. Kerkhoffs
High Rates Of Return To Sports Activities And Work After Osteotomies Around The Knee: A Systematic Review And Meta-Analysis, Alexander Hoorntje, Suzanne Witjes, P. Paul F.M. Kuijer, Koen L.M. Koenraadt, Rutger C.I. Van Geenen, Joost G. Daams, Alan Getgood, Gino M.M.J. Kerkhoffs
Bone and Joint Institute
© 2017, The Author(s). Background: Knee osteotomies are proven treatment options, especially in younger patients with unicompartmental knee osteoarthritis, for certain cases of chronic knee instability, or as concomitant treatment for meniscal repair or transplantation surgery. Presumably, these patients wish to stay active. Data on whether these patients return to sport (RTS) activities and return to work (RTW) are scarce. Objectives: Our aim was to systematically review (1) the extent to which patients can RTS and RTW after knee osteotomy and (2) the time to RTS and RTW. Methods: We systematically searched the MEDLINE and Embase databases. Two authors screened …
Sustainable Bio-Based Phenol-Formaldehyde Resoles Using Hydrolytically Depolymerized Kraft Lignin, Homaira Siddiqui, Nubla Mahmood, Zhongshun Yuan, Ferdinando Crapulli, Luana Dessbesell, Amin Rizkalla, Ajay Ray, Chunbao Xu
Sustainable Bio-Based Phenol-Formaldehyde Resoles Using Hydrolytically Depolymerized Kraft Lignin, Homaira Siddiqui, Nubla Mahmood, Zhongshun Yuan, Ferdinando Crapulli, Luana Dessbesell, Amin Rizkalla, Ajay Ray, Chunbao Xu
Bone and Joint Institute
© 2017 by the authors. In this study bio-based bio-phenol-formaldehyde (BPF) resoles were prepared using hydrolytically depolymerized Kraft lignin (DKL) as bio-phenol to partially substitute phenol. The effects of phenol substitution ratio, weight-average molecular weight (Mw) of DKL and formaldehyde-to-phenol (F/P) ratio were also investigated to find the optimum curing temperature for BPF resoles. The results indicated that DKL with Mw ∼1200 g/mol provides a curing temperature of less than 180°C for any substitution level, provided that F/P ratios are controlled. Incorporation of lignin reduced the curing temperature of the resin, however, higher Mw DKL negatively affected the curing process. …
Titanium Addition Influences Antibacterial Activity Of Bioactive Glass Coatings On Metallic Implants, Omar Rodriguez, Wendy Stone, Emil H. Schemitsch, Paul Zalzal, Stephen Waldman, Marcello Papini, Mark R. Towler
Titanium Addition Influences Antibacterial Activity Of Bioactive Glass Coatings On Metallic Implants, Omar Rodriguez, Wendy Stone, Emil H. Schemitsch, Paul Zalzal, Stephen Waldman, Marcello Papini, Mark R. Towler
Bone and Joint Institute
© 2017 The Authors In an attempt to combat the possibility of bacterial infection and insufficient bone growth around metallic, surgical implants, bioactive glasses may be employed as coatings. In this work, silica-based and borate-based glass series were synthesized for this purpose and subsequently characterized in terms of antibacterial behavior, solubility and cytotoxicity. Borate-based glasses were found to exhibit significantly superior antibacterial properties and increased solubility compared to their silica-based counterparts, with BRT0 and BRT3 (borate-based glasses with 0 and 15 mol% of titanium dioxide incorporated, respectively) outperforming the remainder of the glasses, both borate and silicate based, in these …
Appraisal Of: Role Of Physical Therapists In The Management Of Individuals At Risk For Or Diagnosed With Venous Thromboembolism: Evidence-Based Clinical Practice Guideline, Saravanan Esakki, Joy C. Macdermid
Appraisal Of: Role Of Physical Therapists In The Management Of Individuals At Risk For Or Diagnosed With Venous Thromboembolism: Evidence-Based Clinical Practice Guideline, Saravanan Esakki, Joy C. Macdermid
Bone and Joint Institute
No abstract provided.
An In Vitro Study Of The Role Of Implant Positioning On Ulnohumeral Articular Contact In Distal Humeral Hemiarthroplasty, Roxanna E. Abhari, Ryan Willing, Graham J.W. King, James A. Johnson
An In Vitro Study Of The Role Of Implant Positioning On Ulnohumeral Articular Contact In Distal Humeral Hemiarthroplasty, Roxanna E. Abhari, Ryan Willing, Graham J.W. King, James A. Johnson
Bone and Joint Institute
© 2017 American Society for Surgery of the Hand Purpose To investigate the effect of implant positioning on ulnohumeral contact using patient-specific distal humeral (DH) implants. Methods Seven reverse-engineered DH implants were manufactured based on computed tomography scans of their osseous geometry. Native ulnae were paired with corresponding native humeri and custom DH implants in a loading apparatus. The ulna was set at 90° of flexion and the humeral component (either native bone or reverse-engineered implant) was positioned from 5° varus to 5° valgus in 2.5° increments under a 100-N compressive load. Contact with the ulna was measured with both …
Characteristics Of Therapeutic Alliance In Musculoskeletal Physiotherapy And Occupational Therapy Practice: A Scoping Review Of The Literature, Folarin Babatunde, Joy Macdermid, Norma Macintyre
Characteristics Of Therapeutic Alliance In Musculoskeletal Physiotherapy And Occupational Therapy Practice: A Scoping Review Of The Literature, Folarin Babatunde, Joy Macdermid, Norma Macintyre
Bone and Joint Institute
© 2017 The Author(s). Background: Most conventional treatment for musculoskeletal conditions continue to show moderate effects, prompting calls for ways to increase effectiveness, including drawing from strategies used across other health conditions. Therapeutic alliance refers to the relational processes at play in treatment which can act in combination or independently of specific interventions. Current evidence guiding the use of therapeutic alliance in health care arises largely from psychotherapy and medicine literature. The objective of this review was to map out the available literature on therapeutic alliance conceptual frameworks, themes, measures and determinants in musculoskeletal rehabilitation across physiotherapy and occupational therapy …
Fracture Fixation In The Operative Management Of Hip Fractures (Faith): An International, Multicentre, Randomised Controlled Trial, Aaron Nauth, Aaron T. Creek, Abby Zellar, Abdel Rahman Lawendy, Adam Dowrick, Ajay Gupta, Akhil Dadi, Albert Van Kampen, Albert Yee, Alexander C. De Vries, Alexander De Mol Van Otterloo, Alisha Garibaldi, Allen Liew, Allison W. Mcintyre, Amal Shankar Prasad, Amanda W. Romero, Amar Rangan, Amber Oatt, Amir Sanghavi, Amy L. Foley, Anders Karlsten, Andrea Dolenc, Andrew Bucknill, Andrew Chia, Andrew Evans, Andrew Gong, Andrew H. Schmidt, Andrew J. Marcantonio, Andrew Jennings, Angela Ward, Angshuman Khanna, Anil Rai, Anke B. Smits
Fracture Fixation In The Operative Management Of Hip Fractures (Faith): An International, Multicentre, Randomised Controlled Trial, Aaron Nauth, Aaron T. Creek, Abby Zellar, Abdel Rahman Lawendy, Adam Dowrick, Ajay Gupta, Akhil Dadi, Albert Van Kampen, Albert Yee, Alexander C. De Vries, Alexander De Mol Van Otterloo, Alisha Garibaldi, Allen Liew, Allison W. Mcintyre, Amal Shankar Prasad, Amanda W. Romero, Amar Rangan, Amber Oatt, Amir Sanghavi, Amy L. Foley, Anders Karlsten, Andrea Dolenc, Andrew Bucknill, Andrew Chia, Andrew Evans, Andrew Gong, Andrew H. Schmidt, Andrew J. Marcantonio, Andrew Jennings, Angela Ward, Angshuman Khanna, Anil Rai, Anke B. Smits
Bone and Joint Institute
© 2017 Elsevier Ltd Background Reoperation rates are high after surgery for hip fractures. We investigated the effect of a sliding hip screw versus cancellous screws on the risk of reoperation and other key outcomes. Methods For this international, multicentre, allocation concealed randomised controlled trial, we enrolled patients aged 50 years or older with a low-energy hip fracture requiring fracture fixation from 81 clinical centres in eight countries. Patients were assigned by minimisation with a centralised computer system to receive a single large-diameter screw with a side-plate (sliding hip screw) or the present standard of care, multiple small-diameter cancellous screws. …
Fabrication Of Extracellular Matrix-Derived Foams And Microcarriers As Tissue-Specific Cell Culture And Delivery Platforms, Anna Kornmuller, Cody F.C. Brown, Claire Yu, Lauren E. Flynn
Fabrication Of Extracellular Matrix-Derived Foams And Microcarriers As Tissue-Specific Cell Culture And Delivery Platforms, Anna Kornmuller, Cody F.C. Brown, Claire Yu, Lauren E. Flynn
Bone and Joint Institute
© 2017 Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. Cell function is mediated by interactions with the extracellular matrix (ECM), which has complex tissue-specific composition and architecture. The focus of this article is on the methods for fabricating ECM-derived porous foams and microcarriers for use as biologically-relevant substrates in advanced 3D in vitro cell culture models or as pro-regenerative scaffolds and cell delivery systems for tissue engineering and regenerative medicine. Using decellularized tissues or purified insoluble collagen as a starting material, the techniques can be applied to synthesize a broad array of tissue-specific bioscaffolds with customizable geometries. The approach involves mechanical …
Contributions Of The Anterolateral Complex And The Anterolateral Ligament To Rotatory Knee Stability In The Setting Of Acl Injury: A Roundtable Discussion, Volker Musahl, Alan Getgood, Philippe Neyret, Steven Claes, Jeremy M. Burnham, Cecile Batailler, Bertrand Sonnery-Cottet, Andy Williams, Andrew Amis, Stefano Zaffagnini, Jón Karlsson
Contributions Of The Anterolateral Complex And The Anterolateral Ligament To Rotatory Knee Stability In The Setting Of Acl Injury: A Roundtable Discussion, Volker Musahl, Alan Getgood, Philippe Neyret, Steven Claes, Jeremy M. Burnham, Cecile Batailler, Bertrand Sonnery-Cottet, Andy Williams, Andrew Amis, Stefano Zaffagnini, Jón Karlsson
Bone and Joint Institute
© 2017, European Society of Sports Traumatology, Knee Surgery, Arthroscopy (ESSKA). Persistent rotatory knee laxity is increasingly recognized as a common finding after anterior cruciate ligament (ACL) reconstruction. While the reasons behind rotator knee laxity are multifactorial, the impact of the anterolateral knee structures is significant. As such, substantial focus has been directed toward better understanding these structures, including their anatomy, biomechanics, in vivo function, injury patterns, and the ideal procedures with which to address any rotatory knee laxity that results from damage to these structures. However, the complexity of lateral knee anatomy, varying dissection techniques, differing specimen preparation methods, …
Mechanosignaling Activation Of Tgfβ Maintains Intervertebral Disc Homeostasis, Qin Bian, Lei Ma, Amit Jain, Janet L. Crane, Khaled Kebaish, Mei Wan, Zhengdong Zhang, X. Edward Guo, Paul D. Sponseller, Cheryle A. Séguin, Lee H. Riley, Yongjun Wang, Xu Cao
Mechanosignaling Activation Of Tgfβ Maintains Intervertebral Disc Homeostasis, Qin Bian, Lei Ma, Amit Jain, Janet L. Crane, Khaled Kebaish, Mei Wan, Zhengdong Zhang, X. Edward Guo, Paul D. Sponseller, Cheryle A. Séguin, Lee H. Riley, Yongjun Wang, Xu Cao
Bone and Joint Institute
Intervertebral disc (IVD) degeneration is the leading cause of disability with no disease-modifying treatment. IVD degeneration is associated with instable mechanical loading in the spine, but little is known about how mechanical stress regulates nucleus notochordal (NC) cells to maintain IVD homeostasis. Here we report that mechanical stress can result in excessive integrin αv β6-mediated activation of transforming growth factor beta (TGFβ), decreased NC cell vacuoles, and increased matrix proteoglycan production, and results in degenerative disc disease (DDD). Knockout of TGFβ type II receptor (TβRII) or integrin α v in the NC cells inhibited functional activity of postnatal NC cells …
Measurement Properties Of Paindetect: Rasch Analysis Of Responses From Community-Dwelling Adults With Neuropathic Pain, Tara L. Packham, Joseph C. Cappelleri, Alesia Sadosky, Joy C. Macdermid, Florian Brunner
Measurement Properties Of Paindetect: Rasch Analysis Of Responses From Community-Dwelling Adults With Neuropathic Pain, Tara L. Packham, Joseph C. Cappelleri, Alesia Sadosky, Joy C. Macdermid, Florian Brunner
Bone and Joint Institute
© 2017 The Author(s). Background: painDETECT (PD-Q) is a self-reported assessment of pain qualities developed as a screening tool for pain of neuropathic origin. Rasch analysis is a strategy for examining the measurement characteristics of a scale using a form of item response theory. We conducted a Rasch analysis to consider if the scoring and measurement properties of PD-Q would support its use as an outcome measure. Methods: Rasch analysis was conducted on PD-Q scores drawn from a cross-sectional study of the burden and costs of NeP. The analysis followed an iterative process based on recommendations in the literature, including …
Antegrade Versus Retrograde Nailing Techniques And Trochanteric Versus Piriformis Intramedullary Nailing Entry Points For Femoral Shaft Fractures: A Systematic Review And Meta-Analysis, Nasir Hussain, Farrah Naz Hussain, Corey Sermer, Hera Kamdar, Emil H. Schemitsch, Amir Sternheim, Paul Kuzyk
Antegrade Versus Retrograde Nailing Techniques And Trochanteric Versus Piriformis Intramedullary Nailing Entry Points For Femoral Shaft Fractures: A Systematic Review And Meta-Analysis, Nasir Hussain, Farrah Naz Hussain, Corey Sermer, Hera Kamdar, Emil H. Schemitsch, Amir Sternheim, Paul Kuzyk
Bone and Joint Institute
© 2017 Joule Inc. or its licensors. Background: There are several different techniques commonly used to perform intramedullary (IM) nailing of the femur to fix femoral fractures. We sought to identify significant differences in outcomes of studies comparing 1) trochanteric and piriformis entry and 2) antegrade and retrograde entry in IM nailing of the femur. Methods: We searched MEDLINE, Cochrane and Embase databases and the Orthopaedic Trauma Association and American Academy of Orthopaedic Surgeons websites for comparative studies published from inception to November 2015. Criteria used to select articles for detailed review included use of antegrade and retrograde entry point …
Cardiac Baroreflex Variability And Resetting During Sustained Mild Effort, Mair Zamir, Mark B. Badrov, T. Dylan Olver, J. Kevin Shoemaker
Cardiac Baroreflex Variability And Resetting During Sustained Mild Effort, Mair Zamir, Mark B. Badrov, T. Dylan Olver, J. Kevin Shoemaker
Bone and Joint Institute
This exploratory study assessed the pattern of closed-loop baroreflex resetting using multi-logistic-curve analysis. Operating point gain and ranges of RR-interval (RRI) and systolic blood pressure (SBP) are derived to examine how these relate to sympathetic activation. Sustained low-intensity isometric handgrip exercise, with a period of post-exercise circulatory occlusion (PECO), provided a model to study baroreflex resetting because the progression toward fatigue at constant tension induces a continuous increase in volitional contribution to neuro-cardiovascular control. Continuous measurements of muscle sympathetic nerve activity (MSNA), blood pressure, and RRI were made simultaneously throughout the experimental session. Spontaneous sequence analysis was used to detect …
The European Scleroderma Trials And Research Group (Eustar) Task Force For The Development Of Revised Activity Criteria For Systemic Sclerosis: Derivation And Validation Of A Preliminarily Revised Eustar Activity Index, Gabriele Valentini, Michele Iudici, Ulrich A Walker, Veronika K Jaeger
The European Scleroderma Trials And Research Group (Eustar) Task Force For The Development Of Revised Activity Criteria For Systemic Sclerosis: Derivation And Validation Of A Preliminarily Revised Eustar Activity Index, Gabriele Valentini, Michele Iudici, Ulrich A Walker, Veronika K Jaeger
Bone and Joint Institute
Background Validity of European Scleroderma Study Group (EScSG) activity indexes currently used to assess disease activity in systemic sclerosis (SSc) has been criticised. Methods Three investigators assigned an activity score on a 0–10 scale for 97 clinical charts. The median score served as gold standard. Two other investigators labelled the disease as inactive/moderately active or active/very active. Univariate–multivariate linear regression analyses were used to define variables predicting the ‘gold standard’, their weight and derive an activity index. The cut-off point of the index best separating active/very active from inactive/moderately active disease was identified by a receiver-operating curve analysis. The index …
Erbium-Based Perfusion Contrast Agent For Small-Animal Microvessel Imaging, Justin J. Tse, P. Joy Dunmore-Buyze, Maria Drangova, David W. Holdsworth
Erbium-Based Perfusion Contrast Agent For Small-Animal Microvessel Imaging, Justin J. Tse, P. Joy Dunmore-Buyze, Maria Drangova, David W. Holdsworth
Bone and Joint Institute
Micro-computed tomography (micro-CT) facilitates the visualization and quantification of contrast-enhanced microvessels within intact tissue specimens, but conventional preclinical vascular contrast agents may be inadequate near dense tissue (such as bone). Typical lead-based contrast agents do not exhibit optimal X-ray absorption properties when used with X-ray tube potentials below 90 kilo-electron volts (keV). We have developed a high-atomic number lanthanide (erbium) contrast agent, with a K-edge at 57.5 keV. This approach optimizes X-ray absorption in the output spectral band of conventional microfocal spot X-ray tubes. Erbium oxide nanoparticles (nominal diameter < 50 nm) suspended in a two-part silicone elastomer produce a perfusable fluid with viscosity of 19.2 mPa-s. Ultrasonic cavitation was used to reduce aggregate sizes to 4000 Hounsfield units, and perfusion of vessels < 10 μ m in diameter was demonstrated in kidney glomeruli. The described new contrast agent facilitated the visualization and quantification of vessel density and microarchitecture, even adjacent to dense bone. Erbium’s K-edge makes this contrast agent ideally suited for both single- and dual-energy micro-CT, expanding potential preclinical research applications in models of musculoskeletal, oncological, cardiovascular, and neurovascular diseases.
Tgf-Β Induces Phosphorylation Of Phosphatase And Tensin Homolog: Implications For Fibrosis Of The Trabecular Meshwork Tissue In Glaucoma, Nikoleta Tellios, Jillian C. Belrose, Alexander C. Tokarewicz, Cindy Hutnik
Tgf-Β Induces Phosphorylation Of Phosphatase And Tensin Homolog: Implications For Fibrosis Of The Trabecular Meshwork Tissue In Glaucoma, Nikoleta Tellios, Jillian C. Belrose, Alexander C. Tokarewicz, Cindy Hutnik
Bone and Joint Institute
No abstract provided.
Too Fit To Fracture, Isabel Rodrigues, Joy Macdermid
Too Fit To Fracture, Isabel Rodrigues, Joy Macdermid
Bone and Joint Institute
No abstract provided.
Post-Polymerization Functionalization Of Poly(Ethylene Oxide)–Poly(Β-6-Heptenolactone) Diblock Copolymers To Tune Properties And Self-Assembly, Brooke M. Raycraft, Jarret P. Macdonald, James T. Mcintosh, Michael P. Shaver
Post-Polymerization Functionalization Of Poly(Ethylene Oxide)–Poly(Β-6-Heptenolactone) Diblock Copolymers To Tune Properties And Self-Assembly, Brooke M. Raycraft, Jarret P. Macdonald, James T. Mcintosh, Michael P. Shaver
Bone and Joint Institute
Copolymers were synthesized and functionalized with a variety of moieties to tune self-assembly and install drugs or fluorescent dyes. , Polyester-based amphiphilic block copolymers and their nanoassemblies are of significant interest for a wide range of applications due to the degradability of the polyester block. However, the commonly used polyesters lack functional groups on their backbones, limiting the possibilities to chemically modify these polymers. Described here are new poly(ethylene oxide) (PEO)–poly(β-6-heptenolactone) (PHEL) block copolymers having pendant alkenes at each repeat unit on the PHEL block. First, the self-assembly of these block copolymers in aqueous solution was studied and it was …
Nuclear Receptors Regulate Lipid Metabolism And Oxidative Stress Markers In Chondrocytes, Anusha Ratneswaran, Margaret Man-Ger Sun, Holly Dupuis, Cynthia Sawyez
Nuclear Receptors Regulate Lipid Metabolism And Oxidative Stress Markers In Chondrocytes, Anusha Ratneswaran, Margaret Man-Ger Sun, Holly Dupuis, Cynthia Sawyez
Bone and Joint Institute
No abstract provided.
Evaluation Of An Automated Thresholding Algorithm For The Quantification Of Paraspinal Muscle Composition From Mri Images, Maryse Fortin, Mona Omidyeganeh, Michele Crites Battié, Omair Ahmad
Evaluation Of An Automated Thresholding Algorithm For The Quantification Of Paraspinal Muscle Composition From Mri Images, Maryse Fortin, Mona Omidyeganeh, Michele Crites Battié, Omair Ahmad
Bone and Joint Institute
No abstract provided.
Efficacy Of Workplace Interventions For Shoulder Pain: A Systematic Review And Meta-Analysis, Véronique Lowry, Ariel Desjardins-Charbonneau, Jean Sébastien Roy, Clermont E. Dionne, Pierre Frémont, Joy C. Macdermid, François Desmeules
Efficacy Of Workplace Interventions For Shoulder Pain: A Systematic Review And Meta-Analysis, Véronique Lowry, Ariel Desjardins-Charbonneau, Jean Sébastien Roy, Clermont E. Dionne, Pierre Frémont, Joy C. Macdermid, François Desmeules
Bone and Joint Institute
© 2017 Foundation of Rehabilitation Information. Objective: To perform a systematic review and meta- analysis of randomized controlled trials on the efficacy of workplace-based interventions to prevent or treat shoulder pain. Data sources: A systematic review of 4 databases was performed up to January 2016. Study selection: Randomized controlled trials were included if the intervention under study was a workplace- based intervention performed to prevent or reduce shoulder pain and disability in workers. Data extraction: The methodological quality of the studies was evaluated and meta-analyses were conducted. Pooled mean differences and risk ratios were calculated. Data synthesis: Data from 4 …
Delayed Endothelial Progenitor Cell Therapy Promotes Bone Defect Repair In A Clinically Relevant Rat Model, Brent D. Bates, Charles Godbout, David J. Ramnaraign, Emil H. Schemitsch, Aaron Nauth
Delayed Endothelial Progenitor Cell Therapy Promotes Bone Defect Repair In A Clinically Relevant Rat Model, Brent D. Bates, Charles Godbout, David J. Ramnaraign, Emil H. Schemitsch, Aaron Nauth
Bone and Joint Institute
© 2017 Brent D. Bates et al. The repair of segmental bone defects remains a significant challenge for orthopaedic surgeons. Endothelial progenitor cells (EPCs) have successfully promoted the repair of acute defects in animal models; however, the ability of EPCs to induce the repair of chronic nonhealing defects, such as those often encountered clinically, has not been investigated. Therefore, the purpose of this study was to investigate the ability of EPCs delivered in delayed fashion to induce the repair of nonhealing defects in a clinically relevant model. In order to simulate delayed treatment, 5 mm segmental defects in Fischer 344 …
Methods To Describe Referral Patterns In A Canadian Primary Care Electronic Medical Record Database: Modelling Multilevel Count Data, Bridget L Ryan, Joshua Shadd, Heather Maddocks, Moira Stewart
Methods To Describe Referral Patterns In A Canadian Primary Care Electronic Medical Record Database: Modelling Multilevel Count Data, Bridget L Ryan, Joshua Shadd, Heather Maddocks, Moira Stewart
Bone and Joint Institute
Background: A referral from a family physician (FP) to a specialist is an inflection point in the patient journey, with potential implications for clinical outcomes and health policy. Primary care electronic medical record (EMR) databases offer opportunities to examine referral patterns. Until recently, software techniques were not available to model these kinds of multi-level count data. Objective: To establish methodology for determining referral rates from FPs to medical specialists using the Canadian Primary Care Sentinel Surveillance Network (CPCSSN) EMR database. Method: Retrospective cohort study, mixed effects and multi-level negative binomial regression modelling with 87,258 eligible patients between 2007 and 2012. …
A Respiratory-Gated Micro-Ct Comparison Of Respiratory Patterns In Free-Breathing And Mechanically Ventilated Rats, Nancy L. Ford, Lynda Mccaig, Andrew Jeklin, James F. Lewis, Ruud A.W. Veldhuizen, David W. Holdsworth, Maria Drangova
A Respiratory-Gated Micro-Ct Comparison Of Respiratory Patterns In Free-Breathing And Mechanically Ventilated Rats, Nancy L. Ford, Lynda Mccaig, Andrew Jeklin, James F. Lewis, Ruud A.W. Veldhuizen, David W. Holdsworth, Maria Drangova
Bone and Joint Institute
© 2017 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society. In this study, we aim to quantify the differences in lung metrics measured in free-breathing and mechanically ventilated rodents using respiratory-gated micro-computed tomography. Healthy male Sprague-Dawley rats were anesthetized with ketamine/xylazine and scanned with a retrospective respiratory gating protocol on a GE Locus Ultra micro-CT scanner. Each animal was scanned while free-breathing, then intubated and mechanically ventilated (MV) and rescanned with a standard ventilation protocol (56 bpm, 8 mL/kg and PEEP of 5 cm H2O) and again with …
Design Of Hydrated Porphyrin-Phospholipid Bilayers With Enhanced Magnetic Resonance Contrast, Shuai Shao, Trang Nhu Do, Aida Razi, Upendra Chitgupi
Design Of Hydrated Porphyrin-Phospholipid Bilayers With Enhanced Magnetic Resonance Contrast, Shuai Shao, Trang Nhu Do, Aida Razi, Upendra Chitgupi
Bone and Joint Institute
No abstract provided.