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Improving Learning And Confidence Through Small Group, Structured Otoscopy Teaching: A Prospective Interventional Study, Peng You, Saad Chahine, Murad Husein

Paediatrics Publications

Background: Otologic diseases are common and associated with significant health care costs. While accurate diagnosis relies on physical exam, existing studies have highlighted a lack of comfort among trainees with regards to otoscopy. As such, dedicated otoscopy teaching time was incorporated into the undergraduate medical curriculum in the form of a small group teaching session. In this study, we aimed to examine the effect of a small-group, structured teaching session on medical students' confidence with and learning of otoscopic examination. Methods: Using a prospective study design, an otolaryngologist delivered an one-hour, small group workshop to medical learners. The workshop included …

Urologist Burnout: Frequency, Causes, And Potential Solutions To An Unspoken Entity, Julie Franc-Guimond, Brian Mcneil, Steven M. Schlossberg, Amanda C. North, Alp Sener

Anatomy and Cell Biology Publications

Physician burnout has been linked to decreased job performance, increased medical errors, interpersonal conflicts, and depression. Recent multispecialty studies suggest that urologists have higher rates (up to 63.6%) of burnout compared to physicians in other specialties; however, these reports were limited by low sample sizes.1 We aimed to evaluate the prevalence of urologist burnout, verify risk factors, and recommend preventative measures and solutions for colleagues at risk or suffering from burnout. Urologist burnout is a true entity that transcends level of training and nationality. Its roots appear to be deep-seated in our tireless efforts to strive for excellence in care …

Intelligent Advancements In Location Management And C-Ran Power-Aware Resource Allocation, Emad Ali Aqeeli

Electronic Thesis and Dissertation Repository

The evolving of cellular networks within the last decade continues to focus on delivering a robust and reliable means to cope with the increasing number of users and demanded capacity. Recent advancements of cellular networks such as Long-Term Evolution (LTE) and LTE-advanced offer a remarkable high bandwidth connectivity delivered to the users. Signalling overhead is one of the vital issues that impact the cellular behavior. Causing a significant load in the core network hence effecting the cellular network reliability. Moreover, the signaling overhead decreases the Quality of Experience (QoE) of users. The first topic of the thesis attempts to reduce …

On The Extended Hensel Construction And Its Application To The Computation Of Real Limit Points, Masoud Ataei Jaliseh

Electronic Thesis and Dissertation Repository

The Extended Hensel Construction (EHC) is a procedure which, for an input bivariate polyno- mial with complex coefficients, can serve the same purpose as the Newton-Puiseux algorithm. We show that the EHC requires only linear algebra and univariate polynomial arithmetic. We deduce complexity estimates and report on a software implementation together with experimental results. This work is motivated and illustrated by two applications. The first one is the computation of real branches of space curves. The second one is the computation of limits of real multivariate rational function. For the latter, we present an algorithm for determining the existence of …

Antithrombotic Therapy In Patients Undergoing Coronary Artery Bypass Grafting: A Systematic Review And Network Meta-Analysis, Karla Solo

Electronic Thesis and Dissertation Repository

Comprehensive evidence on the comparative effects of various oral antithrombotic agents on the prevention of saphenous vein graft failure (SVGF) for patients undergoing coronary artery bypass is lacking. A systematic review and frequentist random-effects network meta-analysis of 18 RCTs (n=3,413 patients) comparing the effect of antithrombotic agents on SVGF and clinical outcomes was performed. Based on moderate quality evidence, among the six eligible interventions, dual-antiplatelet therapy with aspirin and clopidogrel was superior to aspirin monotherapy in reducing SVGF (OR: 0.63; 95% CI: 0.41-0.97). No statistical differences were found for major bleeding, mortality, and myocardial infarction between antithrombotic agents, owing to …

Mitigating Non-Linearity In Full Waveform Inversion Using Scaled-Sobolev Norms, Mohammad Akbar Hosain Zuberi

Electronic Thesis and Dissertation Repository

Seismic full waveform inversion (FWI) is a non-linear problem. The Born approximation provides a way to linearize FWI and obtain a gradient in a computationally efficient manner. However, this linearization is only valid if the background velocity is sufficiently known, which often is not possible in practice. There have been various attempts at solving problems associated with the non-linearity of FWI by separating the problems of background and scatterer inversion. Most of the methods, however either depend on the availability of low frequencies and large offsets in the data, or separate the spatial scales completely, which removes the scattered information …

Changes In Enzyme Structural Dynamics Studied By Hydrogen Exchange-Mass Spectrometry: Ligand Binding Effects Or Catalytically Relevant Motions?, Courtney S Fast, Siavash Vahidi, Lars Konermann

Chemistry Publications

It is believed that enzyme catalysis is facilitated by conformational dynamics of the protein scaffold that surrounds the active site, yet the exact nature of catalytically relevant protein motions remains largely unknown. Hydrogen/deuterium exchange (HDX) mass spectrometry (MS) reports on backbone H-bond fluctuations. HDX/MS thus represents a promising avenue for probing the relationship between enzyme dynamics and catalysis. A seemingly straightforward strategy for such studies involves comparative measurements during substrate turnover and in the resting state. We examined the feasibility of this approach using rabbit muscle pyruvate kinase (rM1-PK) which catalyzes the conversion of phosphoenolpyruvate and Mg-ADP to pyruvate and …

Adaption Of Catechol And Reversible Addition-Fragmentation Chain-Transfer (Raft) Chemistries For Water-Based Applications, Olabode Oyeneye

Electronic Thesis and Dissertation Repository

Incorporating the binding chemistry of catechol functionality with RAFT chemistry offers a facile and simplified approach for developing a suite of new 2D and 3D hybrid materials with tailored morphologies. Leveraging both chemistries by synthesizing catechol-end functionalized RAFT agents and catechol-containing monomeric species for RAFT (co)polymerization, this dissertation examined a new series of advanced materials that were designed for water-based applications including model flocculants, thermoresponsive hydrogels, adsorbents and underwater adhesives.

To prepare the RAFT agents, novel trithiocarbonates with several catechol end R groups (as postpolymerization anchors) were synthesized that differ in their carbonyl α-substituents (Dopa-CTAs). These materials were evaluated for …

Why Might A Video Game Developer Join A Union?, Johanna Weststar, Marie-Josee Legault

Management and Organizational Studies Publications

This paper contributes to the union renewal literature by examining the union voting propensity of workers in the high-tech tertiary sector of videogame development toward different forms of unionization. We used exclusive data from a survey of videogame developers (VGD) working primarily in Anglo-Saxon countries. When looking at the factors related to voting propensity, our data indicated that the type of unionism matters and that industry/sectoral unionism is an increasingly salient model for project-based knowledge workers. This is an important policy dimension given that the legal structures and norms in Anglo-Saxon countries still tend to support decentralized enterprise-based unionism. It …

Multiple-Modality Exercise And Mind-Motor Training To Improve Mobility In Older Adults: A Randomized Controlled Trial, Narlon Cassio Boa Sorte Silva, Dawn P. Gill, Michael A. Gregory, John Bocti, Robert Petrella

Lifestyle Research Team

Objective:

To investigate the effects of multiple-modality exercise with or without additional mind-motor training on mobility outcomes in older adults with subjective cognitive complaints.

Methods:

This was a 24-week randomized controlled trial with a 28-week no-contact follow-up. Community-dwelling older adults underwent a thrice -weekly, Multiple-Modality exercise and Mind-Motor (M4) training or Multiple-Modality (M2) exercise with an active control intervention (balance, range of motion and breathing exercises). Study outcomes included differences between groups at 24 weeks and after the no-contact follow-up (i.e., 52 weeks) in usual and dual-task (DT, i.e., serial sevens [S7] and phonemic verbal fluency [VF] tasks) gait velocity, …

Resource Selection, Survival, And Departure Of Adult Female Mallards From The Lake St. Clair Region During Autumn And Winter, Matthew Palumbo

Electronic Thesis and Dissertation Repository

During autumn and winter, mallards (Anas platyrhynchos) maximize fitness through their spatiotemporal distribution to avoid mortality risks while balancing trade-offs to access foods to undergo migration and maintain homeostasis. Thousands of mallards use Lake St. Clair as it is an important, but threatened, migratory staging area in the Great Lakes. My goal was to understand how mallards were selecting resources in the region and potential relationships of selection strategies. My objectives were to estimate resource selection of adult female mallards, in relation to perceived risk of hunting mortality, and determine if selection strategies were related to survival and …

A Performance Based Design Approach For Tall Buildings Under Wind Loading, Fouad Y. Elezaby

Electronic Thesis and Dissertation Repository

The wind design of buildings is typically based on strength provisions under ultimate loads. This is unlike the ductility-based approach used in seismic design, which allows inelastic actions to take place in the structure under extreme seismic events. This research investigates the application of a similar concept in wind engineering. In seismic design, the elastic forces resulting from an extreme event of high return period are reduced by a load reduction factor. A load reduction factor is chosen by the designer and accordingly a certain ductility capacity needs to be achieved in the structure. Two reasons have triggered the investigation …

Feasible Computation In Symbolic And Numeric Integration, Robert H.C. Moir

Electronic Thesis and Dissertation Repository

Two central concerns in scientific computing are the reliability and efficiency of algorithms. We introduce the term feasible computation to describe algorithms that are reliable and efficient given the contextual constraints imposed in practice. The main focus of this dissertation then, is to bring greater clarity to the forms of error introduced in computation and modeling, and in the limited context of symbolic and numeric integration, to contribute to integration algorithms that better account for error while providing results efficiently.

Chapter 2 considers the problem of spurious discontinuities in the symbolic integration problem, proposing a new method to restore continuity …

Rethinking Holocene Ecological Relationships Among Caribou, Muskoxen, And Human Hunters On Banks Island, Nwt, Canada: A Stable Isotope Approach, Jordon S. Munizzi

Electronic Thesis and Dissertation Repository

This dissertation explores the ecology of caribou (Rangifer tarandus spp.) and muskoxen (Ovibos moschatus), and its relevance to human hunters on Banks Island, NWT, Canada, over the last 4000 years, primarily through the isotopic analysis of modern and archaeological faunal remains.

First, we establish baseline carbon and nitrogen isotope relationships between modern vegetation and caribou and muskox bone collagen using Bayesian mixing models. The models indicate that dwarf shrub (Salix arctica) does not contribute significantly to bone collagen isotopic compositions in either species, while sedges and yellow lichen (Cetraria tilesii) do. These findings …

Goals Of Family Caregivers Of Persons With Dementia Across The Caregiving Career, Shalane R. Basque

Electronic Thesis and Dissertation Repository

Understanding goals of family caregivers of persons with dementia is critical to provide effective education and support. However, there is little understanding about family caregivers’ goals. This study investigated goals set by family caregivers prior to an education and training program and whether their goals varied across the caregiving career. Phases of the caregiving career were measured by relationship identity; the extent to which participants viewed their relationship in terms of familial and caregiver roles. Conventional content analysis on goals of 30 family caregivers yielded five categories which varied by relationship identity. Enhancing relationships reflected goals for the familial role …

Adsorbed Gas Behaviour And Guest-Host Interactions In Ultramicroporous Metal-Organic Frameworks, Bligh Desveaux

Electronic Thesis and Dissertation Repository

Metal-organic frameworks (MOFs) are a class of porous materials that have attracted much attention due to their large surface areas, high tunability and their high selectivity for gas adsorption applications. In this work, solid-state nuclear magnetic resonance (SSNMR) experiments and single crystal X-ray diffraction (SCXRD) experiments are used to investigate carbon dioxide adsorption within the ultramicroporous MOFs SIFSIX-3-Zn (Chapter 2) and ZnAtzOx. (Chapter 3). Analysis finds that the CO₂ SIFSIX-3-Zn undergoes wobbling motions with a low temperature dependence, and in ZnAtzOx undergoes wobbling and hopping motions with a low temperature dependence. SCXRD is used to precisely determine the CO …

Assessment Of Dynamic Effect Of Transmission Line Conductor Longitudinal Reaction Due To Downburst Loading, Ibrahim Ibrahim

Electronic Thesis and Dissertation Repository

Due to the locality and non-stationary nature of downburst wind loading events, their effect on the structural response of transmission line structures is of special nature that differs from conventional atmospheric boundary layer wind loading. Acknowledging such difference, the current thesis aims to quantify the dynamic effect associated with downburst loading on transmission line systems. To achieve that, several steps had to be realized, including experimentally verifying the numerical model used for analysis using wind field that was generated using computational fluid dynamics. The verified model was extended from model scale to full scale, where the wind field used for …

Medical Sciences 4300: London-Middlesex Suicide Prevention Council, Harshith Bhaskar, Adnan Husein, Ramin Javaheri-Poya, Sabrina Jetly, Christopher Nguyen, Serena Tejpar

Community Engaged Learning Final Projects

Suicide is an issue that affects people of all backgrounds, and takes the lives of many individuals every year. The London-Middlesex Suicide Prevention Council (LMSPC), an organization established in 1990, seeks to provide suicide prevention training to members of the community. They seek to engage community members in prevention and intervention by recognizing warning signs that may exist among the London-Middlesex region. The three main programs that strive to deliver these skills are ASIST, ASK, and safeTALK, each with a slightly different focus. LMSPC’s current goal is to increase access to these services through external grants and potential partnerships. Our …

Investigating The Regulatory Circuitry Of Protein Kinases And Proteases In Apoptosis, Stephanie A. Zukowski

Electronic Thesis and Dissertation Repository

Apoptosis is a tightly regulated cellular process essential for normal development and tissue homeostasis. Perturbations to apoptotic signaling underscores numerous pathogenic processes emphasizing the importance of apoptotic regulation. During apoptosis, caspases orchestrate cellular degradation through proteolytic cleavage of key structural and enzymatic proteins. In a different manner, protein kinases regulate apoptosis by catalyzing the post-translational phosphorylation of substrate proteins to facilitate either pro- or anti-apoptotic signal transduction pathways. Emerging paradigms have indicated that bidirectional crosstalk between protein kinases and caspases serves to globally fine-tune the equilibrium between signals directing cell survival and cell death. In this regard, identifying points of …

Fabrication And Modification Of Titania Nanotube Arrays For Harvesting Solar Energy And Drug Delivery Applications, Ahmed El Ruby Abdel Rahman Mohamed

Electronic Thesis and Dissertation Repository

The fast diminishing of fossil fuels in the near future, as well as the global warming caused by increasing greenhouse gases have motivated the urgent quest to develop advanced materials as cost-effective photoanodes for solar light harvesting and many other photocatalytic applications. Recently, titania nanotube arrays (TNTAs) fabricated by anodization process has attracted great interest due to their excellent properties such as: high surface area, vertically oriented, highly organized, one-dimensional, nanotubular structure, photoactivity, chemical stability and biocompatibility. This unique combination of excellent properties makes TNTAs an excellent photoanode for solar light harvesting. However, the relatively wide band gap energy of …

Carbohydrates And Fungal Toxin Exposure Influence The Vaginal Microbiota, Metabolome, And Reproductive Health Of Women, Stephanie L. Collins

Electronic Thesis and Dissertation Repository

The reproductive health of women is influenced by microorganisms and their metabolites, namely those representing the vaginal microbiota and those producing toxins that are ingested. To manipulate the vaginal microbiota toward a health-associated, Lactobacillusdominant state, an approach adopting prebiotic lactulose was taken. Using batch culture, lactulose supported Lactobacillus maintenance and positively altered metabolites, while not disrupting indigenous L. crispatus epithelial adherence. The vagina also harbours abundant glycogen, but initial assumptions that lactobacilli utilize it were incorrect. I have now shown that glycogen selectively stimulates organisms associated with dysbiosis and L. iners in a self-limiting manner. Other compounds such as environmental …

Understanding Parent And Child Perceptions Of Barriers And Enablers Influencing Active School Travel, Katherine Wilson

Electronic Thesis and Dissertation Repository

Physical activity plays a fundamental role in developing and sustaining the health and well-being of children. Walking is the most common form of physical activity for people of all ages and the daily journey to and from school is a convenient opportunity for children to be physically active through the use of active school travel. This thesis uses a mixed methods approach, using: (a) parent and child surveys to examine how perceptions of barriers influence children’s active school travel; and (b) participatory mapping exercises and qualitative GIS to understand environmental influences on children’s journeys to and from school. Results suggest …

Polarimetric Synthetic Aperture Radar (Sar) Application For Geological Mapping And Resource Exploration In The Canadian Arctic, Byung-Hun Choe

Electronic Thesis and Dissertation Repository

The role of remote sensing in geological mapping has been rapidly growing by providing predictive maps in advance of field surveys. Remote predictive maps with broad spatial coverage have been produced for northern Canada and the Canadian Arctic which are typically very difficult to access. Multi and hyperspectral airborne and spaceborne sensors are widely used for geological mapping as spectral characteristics are able to constrain the minerals and rocks that are present in a target region. Rock surfaces in the Canadian Arctic are altered by extensive glacial activity and freeze-thaw weathering, and form different surface roughnesses depending on rock type. …

The Development Of Peptide Analogues As Potential Fluorescent And Pet Imaging Probes., Neha Sharma

Electronic Thesis and Dissertation Repository

Molecular imaging is a non-invasive way to diagnose disease. Molecular imaging probes consist of a targeting entity that has a high affinity for a biological target and a signaling source for external detection. Multimodality imaging combines the advantages of different imaging modalities, at the same time eliminating their shortcomings, thereby providing more accurate results. This thesis focuses on the development of novel dual PET/fluorescence imaging agents based on peptides as targeting entities.

Porphyrins are suitable for multimodality imaging applications due to their innate characteristics such as an ability to fluoresce and to coordinate metals. A gallium-protoporphyrin IX(PPIX)-ghrelin based analogue was …

Regulation Of Liver Mitochondrial Metabolism During Hibernation By Post-Translational Modification, Katherine E. Mathers

Electronic Thesis and Dissertation Repository

Hibernation, characterized by a seasonal reduction in metabolism and body temperature, allows animals to conserve energy when environmental conditions (e.g. temperature, food availability) are unfavourable. During hibernation, small mammals such as the 13-lined ground squirrel (Ictidomys tridecemlineatus) cycle between two distinct metabolic states: torpor, where metabolic rate is suppressed by >95% and body temperature falls to ~5 °C, and interbout euthermia (IBE), where metabolic rate and body temperature rapidly increase and are maintained at euthermic levels several hours. Suppression of metabolism during entrance into torpor is paralleled by rapid suppression of liver mitochondrial metabolism. In my thesis, I …

Modelling Of Future Flood Risk Across Canada Under Climate Change, Ayushi Gaur

Electronic Thesis and Dissertation Repository

Climate change has induced changes in key climate variables and hydrological cycle in Canada. In this study, future runoff projections made by 21 GCMs following four Representative Concentration Pathways (RCPs) are used as inputs into a macro-scaled hydrodynamic model: CaMa-Flood to simulate 25 km resolution daily streamflow across Canada for historical (1961-2005) and future (2061-2100) time-periods. Future changes in flood-hazard as a consequence of changes in flooding frequencies of historical 100-year and 250-year return period flood events, and changes in the month of occurrence of extreme flows are analyzed. Changes in flood risk at Canada’s 100 most populous cities and …

Optimal Decomposition Strategy For Tree Edit Distance, Shaofeng Jiang

Electronic Thesis and Dissertation Repository

An ordered labeled tree is a tree where the left-to-right order among siblings is significant. Given two ordered labeled trees, the edit distance between them is the minimum cost edit operations that convert one tree to the other.

In this thesis, we present an algorithm for the tree edit distance problem by using the optimal tree decomposition strategy. By combining the vertical compression of trees with optimal decomposition we can significantly reduce the running time of the algorithm. We compare our method with other methods both theoretically and experimentally. The test results show that our strategies on compressed trees are …

Study Of Motion Of Agglomerates Through A Fluidized Bed, Muhammad Owais Iqbal Bhatti

Electronic Thesis and Dissertation Repository

Formation of agglomerates in Fluid Cokers^TM can cause operating problems, such as excessive shed fouling, which can lead to premature unit shut down. Better understanding of how agglomerates move through a fluidized bed can help improve the design and operation of Fluid Cokers^TM and minimize the risk of agglomerates reaching regions where they cause problems.

To identify key factors in agglomerates motion in a fluidized bed, a new two-dimensional (2D) Radioactive Particle Tracking (RPT) method was developed which tracks model agglomerates motion. In conjunction, a tribo-electric method was used to determine bubble flow distribution in the fluidized bed. …

Three Experiments On Complex Fluids, Yang Liu

Electronic Thesis and Dissertation Repository

The behaviour of complex fluids is fundamentally interesting and important in many applications. This thesis reports on three experiments on the thermal and rheological behaviour of complex fluids. The first is a study of the rheological properties of and heat transport in a saline solution of hydroxyethyl cellulose. This material has been used as a tissue phantom in testing the behavior of medical devices in MRI scanners. We find it behaves as a typical entangled polymer, and flows in response to local heating, such as could occur due to eddy-current heating of metallic devices in an MR scanner. We use …

Ordovician Continental Paleogeography And Paleoenvironment For The Michigan Basin From Paleomagnetic Analysis, Michelle Macrae

Electronic Thesis and Dissertation Repository

This study investigates the paleomagnetic record of Paleozoic rocks from two Michigan basin localities in southwestern Ontario to help close the 40 myr gap in Paleozoic paleomagnetic data. Paleomagnetic data from the Queenston (Upper Ordovician) formation consistently exhibits easily removed viscous remanence, an intermediate and a high temperature component consistent with the unblocking temperatures of magnetite and hematite respectively. Alternating-field and thermal demagnetization in 16–20 steps up to 670º C typically reveal a southeastern, shallow up direction removed from magnetite, and a southwestern, steep up direction removed from hematite. A Late Paleozoic overprint was preserved in the magnetite and a …