Digital Commons Network^™

Metabolic And Physiological Regulation In C. Elegans: Insights Into Sperm Activation And Peroxisome-Mediated Longevity, Yash Flora

LSU Doctoral Dissertations

Organelle dynamics lie at the heart of cellular signaling and metabolic regulation, orchestrating physiological processes such as reproduction and aging across the lifespan. In this dissertation, I investigate how organelle-based signaling coordinates sperm activation and modulates organismal aging in the nematode Caenorhabditis elegans. I identify SPIN-4, a previously uncharacterized Spinster family transporter, as a key regulator of spermiogenesis. SPIN-4 is strongly expressed in developing sperm, localizes to the plasma membrane, and promotes sperm activation by facilitating the export of sphingosine-1-phosphate (S1P). Loss of spin-4 results in defective pseudopod formation, reduced motility, and compromised fertility, phenotypes that can be rescued …

‘Connect And Conquer’: A Health, Social Care, And Charitable Sector Partnership For Physical Self-Management In Parkinson’S., Sophia Hulbert

South West Clinical School Journal

#400WORDS: KNOWLEDGE + ACTION

Final Insufficiently Reclaimed Sites Quality Assurance Project Plan (Qapp), Pioneer Technical Services, Inc.

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Draft Final Quarterly Operations And Maintenance Report Butte Treatment Lagoon System – First Quarter 2025, Pioneer Technical Services, Inc.

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Bayesian-Weighted Mendelian Randomization Reveals Sleep Apnea Syndrome Mediates The Bmi-Chronic Pain Link, Wenbao Shi, Jing Luo, Liu Yang, Dalin Chen, Yongqin Zhang, Jun Peng, Kurt Ruetzler, Manyun Sun, Hua Jin

Faculty, Staff and Student Publications

Background: Body mass index (BMI) has a complex association with a variety of chronic pain conditions, which may be influenced by sleep apnea syndrome (SAS). However, the role of SAS within the causal pathway linking BMI to chronic pain remains unconfirmed. This study explored whether and to what extent SAS serves as a mediator between BMI and chronic pain using Bayesian-weighted Mendelian randomization (BWMR) techniques.

Methods: This study utilized genome-wide association study (GWAS) summary data for BMI (N=461,460) and SAS (N=476,853; based on ICD-10 code diagnostic registries) from the IEU OpenGWAS database, along with chronic pain GWAS data (ICD-10 code-based …

Phase Ii Basket Trial Of Dual Anti-Ctla-4 And Anti-Pd-1 Blockade In Rare Tumors (Dart) Swog S1609: Pancreatic Neuroendocrine Neoplasm (Pnen) Cohort, Sandip Pravin Patel, Jillian Fisher, Young Kwang Chae, Luisa Solis Soto, Anup Kasi, Bhavana Konda, Mark Walshauser, Edwin Parra, Jiexin Zhang, Caroline Duault, Edgar Gonzalez-Kozlova, Ganiraju Manyam, Jianhua Zhang, Hong Chen, Dzifa Yawa Duose, Caddie Laberiano Fernandez, Raja Luthra, Gheath Al-Atrash, Seunghee Kim-Schulze, Holden T Maecker, Ignacio I Wistuba, Sacha Gnjatic, J Jack Lee, Jianjun Zhang, Christine M Magner, Helen X Chen, Elad Sharon, Megan Othus, Christopher W Ryan, Charles Blanke, Cara L Haymaker, Razelle Kurzrock

Faculty, Staff and Student Publications

Purpose: SWOG S1609 Dual Anti-CTLA-4 and anti-PD-1 blockade in Rare Tumors (DART) studied the efficacy of ipilimumab combined with nivolumab across multiple rare tumor types. We report the results of the pancreatic neuroendocrine neoplasm (PNEN) cohort.

Experimental design: Treatment consisted of ipilimumab 1 mg/kg intravenously every 6 weeks with nivolumab 240 mg intravenously every 2 weeks. The primary endpoint was overall response rate (ORR) (Response Evaluation Criteria In Solid TumorsRECIST V.1.1). Secondary endpoints include progression-free survival (PFS), overall survival (OS), and toxicity. Clinical benefit rate (includes ORR plus stable disease (SD)>6 months was examined. Correlative …

The Lived Mental Health Experiences Of African American/Black Mothers With An Infant In The Neonatal Intensive Care Unit During Covid-19, Dr. Shewonyui S. Lurker

Walden Dissertations and Doctoral Studies

African American/Black (AA/B) women are more likely than other women in the United States to give birth prematurely. Experiencing premature birth and infant hospitalization in the neonatal intensive care unit (NICU) during the COVID-19 pandemic may have negatively affected AA/B mothers’ mental health and led them to experience elevated rates of increased posttraumatic stress disorders, depression, anxiety, and postpartum depression. The purpose of this study was to understand the lived mental health experiences of AA/B mothers of infants in the NICU during COVID-19. Feminist theory provided a lens for understanding intersectionality in the experiences of AA/B mothers. Semistructured interviews were …

Havana To Port-Au-Prince: Cuba’S Medical Internationalism Aid To Haiti, Wilner Saint Cyr

Walden Dissertations and Doctoral Studies

Haiti ranks among the lowest in healthcare quality in the Americas, according to the health indicators used by the World Health Organization. Despite national and international efforts to improve health service delivery, access to primary medical care and preventive services is limited, especially in rural areas. In response to a request from the Haitian government following the devastating Hurricane Georges, the arrival of the first Cuban doctors to support ongoing public health needs commenced in December 1998. Recognizing an opportunity for international cooperation, the Haitian president sought assistance from Cuba by signing a bilateral cooperation agreement for initial and ongoing …

Modeling Of Carbonization And Absorption Processes In Soda Ash Production, Nadirbek Rustambekovich Yusupbekov, Djalolitdin Paxritdinovich Mukhitdinov, Fatima Faxritdinovna Iskhakova

Chemical Technology, Control and Management

The article considers the problem of modeling the ammonia-soda process of soda ash production and presents the chemistry of sodium bicarbonate (NaHCO₃) formation. The equation of the kinetics of the reaction, used as a model of the carbonation process, is derived from a system of equations and its computer model is compiled. The system of differential equations reflecting the kinetics of the process was solved in the Mathcad package. The result of the modeling is presented. Based on the experimental data, the dependence of the absorption column performance on temperature and the dependence reflecting the optimal value of the absorption …

The Importance Of The Analog-To-Digital Converter In The Measurement System, Aliev Ravshan, Anvar Djalilov

Chemical Technology, Control and Management

At the moment, many scientific researches are being conducted all over the world on the economical use of water and energy resources. Most of the scientific research works are aimed at improving measurement techniques and technologies, that is, increasing their accuracy. With this in mind, a high-precision analog-to-digital converter due to its unique metrological and technical characteristics was studied in this research paper. As a result of the study, it became clear that the use of a small-sized, high-precision sigma-delta analog-to-digital converter in modern measuring technology has a positive effect on its accurate and efficient operation.

Energy Conversion In Nuclear Batteries, Suhrob Vahob O'G'Li Ibrohimov

Chemical Technology, Control and Management

The transformation of energy in nuclear reactors or processes involves converting mass into energy as a result of nuclear reactions. This can include nuclear fission (splitting heavy atomic nuclei) or nuclear fusion (combining light nuclei). In these processes, energy is released in the form of heat, which can be used for electricity generation or other purposes.

Friction Points Between The Eu Data Act And Wto Law, Pedro R. Borges De Carvalho

Indian Journal of International Economic Law

It has been noted that many of the provisions of the EU Data Act are protectionist in character, seemingly designed to guard data as a national resource to be explored by EU actors first and foremost, and not to be exported, to the detriment of third-country companies. To international trade treaty partners, most notably the United States, it may seem as though the EU’s policy of digital sovereignty, in its current contours, risks violating WTO Law, which is premised on ideals of global free trade and comparative advantage. This essay analyses the most problematic provision of the Data Act in …

The Enjoyment Of Live Magic And Its Relation To Other Forms Of Entertainment, Gustav Kuhn, Emma Rustruck ;, Srishti Kiran Pattundeed, Rebecca Chamberlain

School of Psychology

Magic is a performance art that allows us to experience the impossible. We present data from a questionnaire-based study that examined how the liveness and social and physical proximities of a magic performance affects people’s enjoyment and how this relates to other forms of entertainment. We found moderate to strong evidence to suggest a preference for magic performances that were live to when they were presented on video, but this preference for live performances was also found for dance, theatre, visual arts and sport, but not for film music and comedy. People’s enjoyment of live magic correlated positively with all …

Do They Already Know? Level Of Gender Language Sensitivity Among Education Students, Bethany P. Villanueva, Azil Jane Guingguing, Bryan Abondo, Diane Deuna, Adelyne Abrea

Journal of English and Applied Linguistics

This study, conducted within a Philippine educational setting, assessed gender language sensitivity among education students. Completing two tests, the gender-neutral pronoun usage test and the gender-sensitive language test, 255 randomly selected first- and second-year students participated. Additional qualitative data was gathered through a focus group discussion. Statistical analysis using analysis of variance and Z-tests revealed no significant differences in the use of gender-neutral pronouns based on year level, program, gender identity, and preferred pronouns. However, a significant difference was observed in using gender-sensitive language based on year level and preferred pronouns. Overall, the respondents demonstrated a beginning level of proficiency …

Enhancing Participation In Indonesia's Islamic Capital Market: Exploring Technology Acceptance, Socio-Psychological Factors, And Islamic Financial Literacy, Muhammad Hanif Ibrahim, Akmalia Lutfiaturrosyida Agung Putri, Imas Hasanah, Apia Dewi Agustin, Afnani Rosyida

Jurnal Akuntansi dan Keuangan Indonesia

Background: This research aims to examine the factors influencing Indonesian Muslims' intention to invest in the Islamic capital market by synthesizing three theoretical frameworks: the Technology Acceptance Model (TAM), the Theory of Planned Behavior (TPB), and Islamic Financial Literacy (IFL). Methods: The study utilizes a sample of 250 participants with previous experience in Islamic investment, employing Partial Least Squares Structural Equation Modeling (PLS-SEM) for hypothesis testing and model evaluation. Findings: The findings indicate that perceived convenience substantially influenced perceived usefulness and ease of use. Moreover, perceived usefulness, Islamic financial literacy, and past behavior significantly and positively affect investment attitudes, which …

Analyzing Focus Groups Through Poetic Dialogues: Enhancing Participant Engagement And Representation In Program Evaluation, Catherine E. Sanders, Alexa J. Lamm, Jori N. Hall, Abigail Borron, Maria Navarro, James C. Anderson Ii

The Qualitative Report

Evaluating programs in rural communities can present challenges when large, observable successes, such as infrastructure additions, are limited due to resource challenges. These successes are often quantifiable and easily identified by external stakeholders. However, there are often intangible and social impacts that should be captured as successes of rural community-focused programs that may not fit the more quantitative methodology. Arts-based methodologies, like poetic analysis, can help capture the diverse impacts of a program, while also centering the voices of program participants in the evaluation itself. This study examined the use of poetic dialogues, an application of poetic transcriptions for focus …

The Future Of Foreign Language Learning In The Age Of Artificial Intelligence: A Critical Analysis Of Trends, Challenges, And Opportunities, Ahmad Aljanadbah, Rashid Hamad Al Marri, Hamad Mubarak Almarri

All Works

The integration of Artificial Intelligence (AI) in foreign language education is transforming how languages are taught and learned. This study investigates the current trends, advantages, and challenges of AI applications in language acquisition. Employing a qualitative content analysis method, the research analyzes scholarly publications and practical innovations in AI-based tools, such as adaptive learning systems, intelligent chatbots, and automated writing feedback. The findings highlight AI's potential to enhance personalized instruction, boost learner engagement, and expand access to authentic language materials. Nonetheless, the study also reveals notable limitations, including concerns about data privacy, diminished human interaction, and ethical risks related to …

Robust Contraction Decomposition For Minor-Free Graphs And Its Applications, Bandyapadhyay Sayan, William Lochet, Daniel Lokshtanov, Dániel Marx, Pranabendu Misra, Multiple Additional Authors

Computer Science Faculty Publications and Presentations

We prove a robust contraction decomposition theorem for H-minor-free graphs, which states that given an H-minor-free graph G and an integer p, one can partition in polynomial time the vertices of G into p sets Z₁,… ,Z_p such that tw(G/(Z_i ⧵ Z')) = O(p + |Z'|) for all i ∈ [p] and Z' ⊆ Z_i. Here, tw(⋅) denotes the treewidth of a graph and G/(Z_i ⧵ Z') denotes the graph obtained from G by contracting all edges with both endpoints in Z_i ⧵ Z'. Our result generalizes earlier results by Klein [SICOMP 2008] and Demaine et al. [STOC 2011] based …

The Impact Of Cost Leadership On Financial Distress Mediated Environmental, Social, And Governance, Steven Asher, Meythi Meythi, Riki Martusa, Rapina Rapina

Jurnal Akuntansi dan Keuangan Indonesia

Background: This study investigates the mediating role of environmental, social, and governance (ESG) performance in the relationship between cost leadership and financial distress among companies in Indonesia. Methods: Using path analysis, the research analyzed a sample of 43 firms listed on the Indonesia Stock Exchange from 2018 to 2022. Findings: The findings indicate that cost leadership positively affected ESG; however, no direct relationship was observed between cost leadership or ESG and financial distress. The mediation analysis reveals that ESG acted as a mediator, linking cost leadership to a reduced risk of financial distress. Conclusion: These results highlight the importance of …

Data-Driven Constrained Control, Ali Kashani

Mechanical Engineering ETDs

Ensuring safety is a fundamental challenge. Traditional methods often rely on precise mathematical models, which are difficult, impractical, or costly to obtain for real-world systems with complex, nonlinear dynamics. This dissertation develops direct data-driven control approaches that enable safe and efficient operation of nonlinear systems without requiring explicit models or performing system identification. This effort leverages machine learning, optimization, and control theory to bridge theoretical rigor and practical applicability. Deterministic guarantees are provided based on the Lipschitz continuity of the system, and probabilistic guarantees through scenario optimization. The computation of safe sets is performed using one-shot approaches with broad neural …

Interleukin-6 And Tnf-Alpha As Biomarkers Associated With Ace2 Snps Rs1978124 And Rs2074192 In Patients Type Ii Diabetes Mellitus With Covid-19, Ghaleb Hussein Al-Saeedi, Wisam Salih Abood

Al-Qadisiyah Medical Journal

Background: Diabetics have a unique set of challenges as a result of the current SARS-CoV-2 Coronavirus illness 2019 (COVID-19) epidemic. It predisposes to a particularly severe course of the disease and doubles the risk of dying from COVID-19.

Aim: Was to study the analysis and comparison of the relationship between polymorphisms and immune cytokines in the pathogenesis of type 2 diabetes in SARS-CoV-2 patients.

Methods: From January 2022 to April 2022, blood samples were drawn from 120 patients who were divided into three groups for a cross-sectional and case-control study admitted to COVID-19 isolation wards: 40 of whom were infected …

Gene And Alleles Of Tyk2 (Rs11085727) And Tyk2 (Rs34536443) Polymorphisms In Covid-19 Patients Using Arms-Pcr., Thuraya Habeeb, Adnan Aubaid

Al-Qadisiyah Medical Journal

The clinical presentation of COVID-19 varies greatly from case to another, with host characteristics playing a pivotal role. The immune system is a pivotal function in establishing the course of SARS-COV-2 infection. Severe instances of COVID-19 and the resulting death are caused less by the virus itself than by the destructive unrestrained immune response. Among the host determinants for poor disease prognosis is probably genetic vulnerability to dysregulated immune response. The objective of this work is to examine some of the host genetic variables that are being studied in relation to the severity of COVID-19. The complex relationship between autoimmunity …

Assessment Of Alpha Emission In The Saliva Of The Smokers Using Cr-39 (Ssntds), Mayyadah Hasan Rhaif Al-Sahlanee

Al-Qadisiyah Medical Journal

Background: The concentration of radionuclides in the saliva and blood samples are a good indicator of the human body’s radioactive contamination, the objective of current study was to design across sectional study to assess the alpha particals emitted from the smoker and nonsmoker saliva and blood samples. Materials and Method: The saliva and blood samples were collected from 88 healthy male and famel smoker and non-smoker aged 18- 82 years old. In saliva and blood samples from smokers and nonsmokers, the alpha track density was determined utilizing the efficient fission track analysis approach with CR-39 nuclear track detector. Results: High …

Government Information Clarity And Digital Engagement As Driving Forces Behind Digital Resilience On The Jepin Smart City Platform, Winda Chelsea Meisari, Muliawati -, Siti Fatimah

Jurnal Vokasi Indonesia

This study examines the influence of information clarity and government digital engagement on the digital resilience of urban communities, using the case study of the Jendela Pontianak Integrasi (JEPIN) platform. The research employs a quantitative approach using Partial Least Squares Structural Equation Modeling (PLS-SEM) with WarpPLS 7.0, involving 100 respondents from the city of Pontianak. The results indicate that information clarity (β = 0.49; p < 0.001) and government digital engagement (β = 0.37; p < 0.001) have a positive and significant effect on digital resilience. The model demonstrates strong reliability (Composite Reliability: 0.847–0.914; Cronbach’s Alpha: 0.772–0.882), good validity (factor loading > 0.5; AVE > 0.5), and a high level of model fit (GoF = 0.569). The R² value of 0.517 shows that the model explains 51.7% of the variance in digital resilience, while the Q² value of …

Breaking Barriers Exploring Guardianship & Public Administration Challenges Facing Egyptian Widows, Caroline Maher

Theses and Dissertations

This thesis examines the influence of guardianship policies and the administrative infrastructure on the well-being of widows' families in Egypt. Widows in Egypt encounter significant challenges in exercising their guardianship rights due to patriarchal norms, bureaucratic hurdles, inefficient systems, and limited access to information. These obstacles can negatively impact their children's well-being, as well as economic and social stability. Despite social media activism, calls for administrative reforms, and legislative debates, no changes have occurred. This study aims to conduct in-depth exploratory qualitative research to analyze the challenges and limitations of current guardianship policies and administrative systems affecting widows’ families in …

Navigating Identity Tensions And Emotional Struggles: Indonesian Pre-Service Teachers In The Teaching Practicum, Afrianto Daud, Minh Hue Nguyen, Raqib Chowdhury

The Qualitative Report

Despite the critical role of teaching practicums in teacher education, little is known about how pre-service teachers navigate emotional tensions in Indonesia. In this study, we aim to explore the nature of tensions and emotional struggles pre-service teachers face and their coping mechanisms. Seven pre-service teachers from the English Education department at an Indonesian public university were purposefully selected. Data was collected through semi-structured interviews before the practicum and a focused group discussion after the program. Semi-structured interviews and focus group discussions were used to capture rich, in-depth accounts of participants’ experiences, while thematic analysis provided a structured approach to …

Community Development Initiatives Implementation And Disaster Risk Management Practices In Calamba City Barangays, Jose Roderick S. Aguila

Social Sciences and Development Review

This study examined the relationship between community development frameworks and disaster risk management (DRM) practices using a quantitative descriptive correlational design. Data were gathered from 150 respondents, 40 barangay officials, and 110 community members from Barangays Palingon, Lingga, and Sampiruhan in Calamba City through a validated researcher-made survey (CVR = 1.00) utilizing a four-point Likert scale. Statistical analyses included a paired T-test (.05 significance level) and Pearson Product-Moment Correlation. Findings indicated that community development initiatives and DRM practices were generally "Fully Implemented" and "Fully Manifested," with Self-Understanding (3.49) and Preparedness (3.62) receiving the highest ratings, while Engage and Empower, Reflect …

Babaeng Frontliner At Covid-19 Sa Pilipinas: Batayan Para Sa Isang Epektibong Tugon Sa Pandemya Na Nakatuon Sa Gender, Arianne Nicole N. Fernando

Social Sciences and Development Review

While the mortality rates for men are higher, the socioeconomic impact of the COVID-19 pandemic hit women differently. This qualitative study examines the experiences of eight Filipina frontliners who continued to work during the General Community Quarantine in Metro Manila. Respondents were selected through purposive sampling. The primary data collection method was in depth interview. Phenomenological study was utilized for data analysis. The research resulted in three major themes which emerged out of the experiences shared by the female frontliners (1) there exists a problem in safety and transportation among female frontliners; (2) stress develops from a high-risk work task; …

Profile, Trends, And Determinants Of Pregnancy Termination Among Filipino Women, Mejedin R. Tena

Social Sciences and Development Review

Cultural and legal barriers force many Filipino women to undergo unsafe and secret abortions. This study examines the profile of women who terminated pregnancy among those who gave birth in the last five years according to selected independent variables, and the trends in pregnancy termination from 1992 to 2022 all National Demographic and Health Surveys. It also identified the determinants of pregnancy termination and estimated its likelihood. The analysis accounted for the complex survey design. Descriptive statistics, bivariate analysis, and multivariate logistic regression were employed. Results show that nearly 13% of women who gave birth in the last five years …

Advancements In Mooring Systems For The Oe35 Wave Energy Converter: Dynamic Design And Validation, Chenyu Zhao, Faryal Khalid, Tony Lewis, Sean Barrett, Brian Mcswiney, Rémy Cr. Pascal, Bernardo Kahn, Lars Johanning

School of Engineering, Computing and Mathematics

This research presents a comprehensive analysis of the mooring system design for the 1 MW OE35 wave energy converter, which is being developed by the WEDUSEA project. The study centres on the dynamic analysis of mooring configurations using Orcaflex software to simulate the environmental and operational conditions expected at the deployment site. The analysis involved an iterative design and validation process, refined through both numerical modelling and basin testing. These tank tests were crucial for validating the Orcaflex model outcomes by providing a controlled environment to observe the physical behaviours of the proposed mooring configurations under simulated sea conditions. The …