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Articles 71611 - 71640 of 1826584
Full-Text Articles in Entire DC Network
Ex-Slave Narrative - James Cape, Sheldon F. Gauthier, James Cape
Ex-Slave Narrative - James Cape, Sheldon F. Gauthier, James Cape
Writers' Program of the Work Projects Administration in the State of Texas, Fort Worth City Guide and History Draft Records
A transcript of an Ex-Slave Narrative interview conducted by Sheldon F. Gauthier for the Works Progress Administration's Federal Writers' Project in the 1930s with James Cape. Cape, who believed he was over 100 years old at the time of the interview, was born into slavery in southeast Texas on the cattle ranch of Bob Houston. His primary work while enslaved was as a horse wrangler and cowhand. He describes his work as a cowhand, including riding horses, cattle, stampedes, and trail drives. He also describes joining the Confederate Army to care for the horses, but later being forced into fighting …
The Legal Regulation Of E-Commerce In Lebanon, Dolly Abouchakra
The Legal Regulation Of E-Commerce In Lebanon, Dolly Abouchakra
BAU Journal - Journal of Legal Studies - مجلة الدراسات القانونية
In the digital age, the economy and commerce sectors in Lebanon, as well as globally, have embraced advancements, leading to the emergence of e-commerce with its multifaceted models, thereby establishing the electronic commercial entity. These advancements necessitate a profound technological transformation, which, in turn, introduces critical legal challenges. These challenges threaten the stability and growth of such entities within traditional legal frameworks that are insufficiently equipped to address the complexities of the digital environment and the noticeable absence of specialized regulations. This study highlights the inadequacy and disjointed nature of the Lebanese legal framework governing electronic commercial entities. The current …
The Dynamics Of Urbanization And Changes In Ekistics Elements: A Case Study Of Surakarta City, Sarah Astita
The Dynamics Of Urbanization And Changes In Ekistics Elements: A Case Study Of Surakarta City, Sarah Astita
Cities and Urban Development Journal
Urbanization has become a driving force behind significant spatial, environmental, and socio-economic transformations in urban areas, including Surakarta, the most densely populated city in Central Java. The rapid increase in population and urban expansion has led to drastic changes in land use and the structure of human settlements. This study aims to analyze the impact of urbanization on the ekistic elements of Surakarta (nature, humans, society, space/shells, and networks) and how these changes manifest spatially over time. A descriptive qualitative approach is employed using literature analysis and the interpretation of Landsat satellite imagery from 2011 and 2022. The findings show …
Nsu Otd Peer Mentoring Program: Improving Otd Student Knowledge And Professionalism, Mckinley Rivas
Nsu Otd Peer Mentoring Program: Improving Otd Student Knowledge And Professionalism, Mckinley Rivas
Department of Occupational Therapy Entry-Level Capstone Projects
No abstract provided.
Constructing Sculptural Wearables: Indigenous Steam Education At The Intersection Of Art And Science, Patricia Andersen
Constructing Sculptural Wearables: Indigenous Steam Education At The Intersection Of Art And Science, Patricia Andersen
Theses and Dissertations
This paper describes an approach to STEAM education in which art is viewed as a unique discipline with distinct ways of thinking. The researchers developed and evaluated a STEAM education program to explore how art and science work together to expand and accelerate inventive thinking among Native American middle school students who participated in American Indian Services (AIS) Pre-Freshman Engineering Program (PREP). An important context of this project was the unique local environment and culture that included Diné (din-eh) culture in Gallup, NM. We hypothesize that integrating culturally responsive transdisciplinary art into an existing STEM summer program will increase students' …
Belonging Starts With You: Exploring Trust, Belonging, And Spiritual Connection In The Success Of Culturally Diverse Students In Higher Education, Moises Aguirre
Theses and Dissertations
Cultivating trust and belonging is essential for student success in higher education, particularly for students from diverse cultural backgrounds (DCB) who face unique challenges in developing these connections. Research highlights lower levels of trust reported by DCB students toward peers and institutions, adversely impacting their academic performance and social integration (Van Maele & Van Houtte, 2010). The urgency of these issues is underscored by the demographic evolution in Utah's educational system, with projections indicating significant growth of students' diversity by 2065 (Hollingshaus et al., 2019). Because of these projected developments, this study investigates how DCB students conceptualize and experience trust …
What's The Joke Princess?: A Qualitative Analysis On The Comic Representation Of Women In Disney Sitcoms, Julia J. Lee
What's The Joke Princess?: A Qualitative Analysis On The Comic Representation Of Women In Disney Sitcoms, Julia J. Lee
Theses and Dissertations
This thesis investigates the comedic representation of women in recent Disney sitcoms (2019"“2025), focusing on the framing devices, stereotypes, and situational contexts through which gendered humor is constructed and reinforced. Drawing from existing literature on comedic archetypes, the study identifies six historically dominant comedic frames and reveals eleven emergent subframes that complicate, reinforce, or expand these traditional portrayals. Through qualitative content analysis and systematic coding of selected Disney sitcoms, this study identifies consistent character traits and comedic techniques that span multiple frames and contexts, revealing how these patterns influence audience perceptions of femininity. The study situates these frames within three …
Discovering And Designing Novel Perovskite Photovoltaic Materials Via Machine Learning, Junyeong Ahn
Discovering And Designing Novel Perovskite Photovoltaic Materials Via Machine Learning, Junyeong Ahn
Discovery Undergraduate Interdisciplinary Research Internship
Perovskite semiconductors are promising materials for high-efficiency photovoltaics due to their outstanding optoelectronic properties, emerging as a sustainable energy source through solar cell applications. Perovskites with the ABX₃ composition (A, B = metal or organic cations with varying oxidation states; X = chalcogen or halogen anions) have gained interest for their excellent phase stability and compositional tunability. However, combinatorial possibilities arising from the many choices of A, B, and X site species, and their respective mixing fractions, a large number of possible ABX₃ perovskites remain undiscovered. In this work, we used machine learning (ML) methods to design new stable and …
Is There A More Effective Design For Quadrat To Increase Ease Of Use And Vegetation Density?, Scott M. Burke Jr., Kristen M Bellisario
Is There A More Effective Design For Quadrat To Increase Ease Of Use And Vegetation Density?, Scott M. Burke Jr., Kristen M Bellisario
Discovery Undergraduate Interdisciplinary Research Internship
Quadrats are a special tool in the ecology field that allows the measurement of vegetation density for further data analysis of a habitat. The larger the quadrat cross-sectional area, the better the results of the data, which in turn can make the quadrat hard to carry through field sites. In wildlife corridor research, quadrat surveys provide a quantitative metric for habitat suitability. In this work, we consider the efficiency and ease-of-use benefits for field work in the design of a collapsible version of a quadrat using a House of Quality (standard metric for new design requirements) to assess the customer …
Logged Out Or Logged In? Stress, Burnout, And Job Satisfaction Between Remote And In-Person Workers, Ryan H. Nguyen
Logged Out Or Logged In? Stress, Burnout, And Job Satisfaction Between Remote And In-Person Workers, Ryan H. Nguyen
McNair Scholars Research
There is an increasing concern about job-related stress, burnout, and satisfaction. This study explores stress, burnout, and job satisfaction patterns among remote and in-person workers. The sample for this study comprised 88 adults recruited through social media who voluntarily completed a 40-item Google Forms survey. The survey included 10 demographic items and incorporated items from three inventories: Perceived Stress Scale (PSS), Copenhagen Burnout Inventory (CBI), and Aggregate Job Satisfaction Scale (AJSS). The data were analyzed quantitatively using Pearson correlation and independent samples t-tests to assess the relationship among burnout, work-related stress, and job satisfaction, and to determine the influence of …
Analysis Of The Impact And Adaptation Of Tidal Floods From Coastal Landscape Area Communities In Poasia District, Kendari City, Indonesia, La Ode Hadini, La Aba, Noor Husna Khairisa, Nikita Jasmine Almira
Analysis Of The Impact And Adaptation Of Tidal Floods From Coastal Landscape Area Communities In Poasia District, Kendari City, Indonesia, La Ode Hadini, La Aba, Noor Husna Khairisa, Nikita Jasmine Almira
Jurnal Pendidikan Geografi: Kajian, Teori, dan Praktek dalam Bidang Pendidikan dan Ilmu Geografi
Poasia District is located in the coastal area of the southern part of Kendari City, which is highly susceptible to tidal flooding. However, the extent of the community's exposure to these events and their subsequent adaptation measures remain to be fully delineated. This study examines the impacts of tidal flooding and the adaptation patterns of the Poasia Coastal Community to the tidal flood disaster. This research employed a descriptive qualitative method, which was carried out through document review, interviews involving 34 respondents, and field observations. The results of this study indicate that tidal flooding exerts a negative impact on the …
Toxicological And Environmental Assessment Of Trace And Heavy Metals In Harnoi Coal Deposits, Abbottabad, Khyber Pakhtunkhwa, Pakistan, Muhammad Sajid, Shaukat Khan, Muhammad Kashif, Khan Amir Khan, Muhammad Junaid
Toxicological And Environmental Assessment Of Trace And Heavy Metals In Harnoi Coal Deposits, Abbottabad, Khyber Pakhtunkhwa, Pakistan, Muhammad Sajid, Shaukat Khan, Muhammad Kashif, Khan Amir Khan, Muhammad Junaid
Jurnal Pendidikan Geografi: Kajian, Teori, dan Praktek dalam Bidang Pendidikan dan Ilmu Geografi
Mining and burning of coal release various toxic substances that can contaminate both surface and groundwater, thereby posing significant risks to human health, especially for households located near mines, coal deposits, or coal-fired power stations. This research examines the environmental effects of coal mining in the Harnoi Region of Abbottabad, Khyber Pakhtunkhwa, Pakistan. Four mining sites were randomly selected within the study area, and eight coal samples were collected and analyzed using atomic absorption spectrophotometry to determine the concentrations of trace and heavy metals. The findings indicate that Harnoi coal contains elevated concentrations of arsenic, zinc, lead, cadmium, nickel, cobalt, …
July 30, 2025 Blazer Weekly, University Of Alabama At Birmingham
July 30, 2025 Blazer Weekly, University Of Alabama At Birmingham
Blazer Weekly (student newsletter)
No abstract provided.
“Falling Short Of Our Humanity”: Shame And Queer Catholic Families, M.T. Davila
“Falling Short Of Our Humanity”: Shame And Queer Catholic Families, M.T. Davila
Religious & Theological Studies Faculty Publications
Queer Catholic Families (QCF) negotiate a complicated landscape of belonging and exclusion in the church that they love. In this dynamic, shame figures as a theological and moral qualifier of their experience when observed through the lens of the Catholic Church's teaching on sexuality and gender. Understanding how shame is experienced in these families, how it deepens a rift between families and the community, and how families find ways to nourish and preserve their links to the Church, ought to be a primary ethical and pastoral task of the Church.
Dynamic Analysis And Fatigue Life Evaluation Of Single Herringbone Planetary Gear System With Crack Fault, Dongping Sheng, Jie Yang, Chun Su
Dynamic Analysis And Fatigue Life Evaluation Of Single Herringbone Planetary Gear System With Crack Fault, Dongping Sheng, Jie Yang, Chun Su
Journal of Mechanical Engineering Science and Technology (JMEST)
The herringbone planetary gear transmission is widely used due to its exquisite compact structure, excellent load-bearing capacity, and stable transmission characteristics. However, root crack is one of the most common failure modes of gears. A cracked herringbone planetary gear system is taken as research object. The sun gear with crack fault is studied from the aspect of modal and transient dynamic analysis, and the related results are compared with the healthy gear. Based on the transient dynamic analysis of the herringbone teeth with cracks, a fatigue life evaluation is conducted. Firstly, the results show that no significant difference between the …
Investigation Of The Influence Of Warhead Shape And Type Of Missile Weapon Material Counter-Training Tank Weapons Simulation Approach, Transisma Budiarta, Haris Puspito Buwono, Radhi Nurvian Amrullah
Investigation Of The Influence Of Warhead Shape And Type Of Missile Weapon Material Counter-Training Tank Weapons Simulation Approach, Transisma Budiarta, Haris Puspito Buwono, Radhi Nurvian Amrullah
Journal of Mechanical Engineering Science and Technology (JMEST)
This study analyzes the effect of warhead shape and material variations on pressure, temperature, and lift on training missiles using CAD-based simulation methods. The variations of warhead shapes tested include flat, flat radius, and tapered, while the materials used are rubber, ABS, and PE. The simulation results show that the tapered warhead shape with PE material produces the lowest pressure (50.3 MPa) due to more efficient pressure release and low friction properties. Conversely, the Flat shape produces the highest pressure (69.1 MPa) on all materials due to flow stagnation. In terms of temperature, the Flat Radius warhead with PE and …
Characterization Of Curcumin As A Coating Material For Polymer-Free Stents Interms Of Morphology And Release, Ameliyana R.S.P.A. Yani, Muhammad Kusumawan Herliansyah
Characterization Of Curcumin As A Coating Material For Polymer-Free Stents Interms Of Morphology And Release, Ameliyana R.S.P.A. Yani, Muhammad Kusumawan Herliansyah
Journal of Mechanical Engineering Science and Technology (JMEST)
The use of bare metal stents over the long term often leads to the re-narrowing of blood vessels, prompting a shift to drug-eluting stents (DES). However, the use of polymers in DES has been known to trigger inflammation and thrombosis in the arteries. As an alternative, polymer-free drug-eluting stents (PF-DES) have emerged as a safer option. In this study, curcumin was selected as the primary coating material for PFDES using the electrophoretic deposition method. The effects of varying curcumin concentrations (125 µg/ml, 250 µg/ml, and 500 µg/ml) were examined to understand their impact on deposition morphology, coating weight, chemical bonding …
Toolpath Motion Strategy And Feed Rate In Cnc Milling On Energy Consumption Of Machining Process, Luqman Dwi Saputra, Eko Yudiyanto
Toolpath Motion Strategy And Feed Rate In Cnc Milling On Energy Consumption Of Machining Process, Luqman Dwi Saputra, Eko Yudiyanto
Journal of Mechanical Engineering Science and Technology (JMEST)
The use of CNC milling machines to produce components, especially aluminum brackets used for automotive, is one of the advances in the industrial field. The use of CNC milling machines has the advantage of producing processes with speed accuracy, and better workpiece quality than conventional machines. This research investigates energy consumption in the CNC milling process by varying the toolpath motion strategies—Zigzag, Constant Overlap Spiral, Parallel Spiral, and Parallel Spiral Clean Corners—as well as feed rates of 700 mm/min, 800 mm/min, 900 mm/min, and 1000 mm/min. The goal is to find out the best parameters for using energy in the …
Boiling Heat Transfer Coefficient And Critical Heat Flux On Conical Cylindrical Copper Under Surface Modification, Muhammad Dimyati Nashrullah, Andi Sanata, Imam Solahuddin, Nasrul Ilminnafik, Indro Pranoto, Adhika Widyaparaga
Boiling Heat Transfer Coefficient And Critical Heat Flux On Conical Cylindrical Copper Under Surface Modification, Muhammad Dimyati Nashrullah, Andi Sanata, Imam Solahuddin, Nasrul Ilminnafik, Indro Pranoto, Adhika Widyaparaga
Journal of Mechanical Engineering Science and Technology (JMEST)
This study examined how surface roughness and nanoceramic coating, influences the boiling heat transfer coefficient (BHTC) and critical heat flux (CHF) of a conical cylindrical copper test specimen. Three test specimens exhibiting surface roughness of 0.22 µm, 0.14 µm, and 0.04 µm were analyzed for comparison. Two additional test specimens were treated with nanoceramic coatings utilizing silicon carbide as the base material: one specimen received a single-layer coating and the second was applied with a double-layer coating. The behavior of the bubbles was closely observed with a high-speed camera to deepen the analysis. The experimental results showed that the test …
Development Of Adjustable Static Test Equipment For Below-Knee Prosthetic Feet: A Case Study, Firmansyah Hafizh Rizal Nurrokhim, Fauzan Raka Mawandi, Puspa Dinda Safitri, Imam Mahmudah, Dwiky Mirnanda, Ndaru Adyono, Wahyu Dwi Lestari
Development Of Adjustable Static Test Equipment For Below-Knee Prosthetic Feet: A Case Study, Firmansyah Hafizh Rizal Nurrokhim, Fauzan Raka Mawandi, Puspa Dinda Safitri, Imam Mahmudah, Dwiky Mirnanda, Ndaru Adyono, Wahyu Dwi Lestari
Journal of Mechanical Engineering Science and Technology (JMEST)
The high prevalence of physical disabilities in Indonesia, particularly among the productive-age population, highlights the urgent need for advancements in prosthetic technology. While local fabricators have begun producing prosthetic feet, the lack of standardized testing procedures compromises safety and performance. This study addresses that gap by developing an adjustable static testing device tailored for below-knee prosthetic feet, focusing on keel and heel tests to evaluate mechanical performance. The device includes a jig-fixture platform adjustable to 8° and 15° for heel and keel tests, respectively. It applies a 1230 N load based on AOPA standards and integrates load and displacement sensors …
Characterization Of Bamboo Petung Fiber Reinforced Composites With Environmentally Friendly Enzymes, Rudianto Raharjo, Teguh Dwi Widodo, Redi Bintarto, Fikrul Akbar Alamsyah
Characterization Of Bamboo Petung Fiber Reinforced Composites With Environmentally Friendly Enzymes, Rudianto Raharjo, Teguh Dwi Widodo, Redi Bintarto, Fikrul Akbar Alamsyah
Journal of Mechanical Engineering Science and Technology (JMEST)
Natural fiber composites are a good choice for many businesses uses because of their better mechanical properties and are friendly environment. Researchers are currently looking into bamboo petung fiber (BPF) and epoxy composites as alternative to synthetic fibers and products made from petroleum. This study's goal is to improve the overall performance of these composites while reducing the need for non-organic materials. This study used the various concentration of bromelain enzyme in BPF to changes the mechanical and physical properties of epoxy composites made from BPF. Composites were characterized the mechanical properties including tensile strength using tensile tester, impact strength …
Tear Resistance Evaluation Of Room Temperature Vulcanizing Silicone Rubber: A Comparative Study, F R. Mawandi, P D. Safitri, D Mirnanda, F H. R. Nurrokhim, Ndaru Adyono, W D. Lestari
Tear Resistance Evaluation Of Room Temperature Vulcanizing Silicone Rubber: A Comparative Study, F R. Mawandi, P D. Safitri, D Mirnanda, F H. R. Nurrokhim, Ndaru Adyono, W D. Lestari
Journal of Mechanical Engineering Science and Technology (JMEST)
Room Temperature Vulcanizing (RTV) silicone cures at room conditions, providing tear resistance and flexibility to a wide range of industries. Yet, its mechanical performance improvement continues to be difficult when it is filled and catalyzed. In this work, the tear resistance of three RTV materials—RTV 48, RTV 683, and RTV M4503—is investigated with different talc (2–4 wt.%) and catalyst (40–60 wt.%) formulations. Tear resistance testing per ASTM D624 yielded average and standard deviation values for material consistency determinations. Comparative analysis is also given in the research to ascertain the effect of over-cross-linking on elasticity and structural morphology. RTV 48 experienced …
Effect Of Thickness Of Nanofiber Separator Membrane Pan/Pvdf On Supercapacitor’S Performance, Silvia Nurlaili Agustina, Markus Diantoro, Hartatiek Hartatiek, Nasikhudin Nasikhudin
Effect Of Thickness Of Nanofiber Separator Membrane Pan/Pvdf On Supercapacitor’S Performance, Silvia Nurlaili Agustina, Markus Diantoro, Hartatiek Hartatiek, Nasikhudin Nasikhudin
Journal of Mechanical Engineering Science and Technology (JMEST)
Separators in supercapacitors have an important role as intermediaries for ions that pass during the chargedischarge process and affect the performance of supercapacitors. Therefore, a comprehensive study is needed related to separator characteristics, including morphology, pore size, diameter, functional group, and electrochemical performance of separator membranes from PAN/PVDF composites. The separator membrane was synthesized using the electrospinning method with thickness variation (2, 4, 6, 8, and 10 layers), followed by supercapacitor fabrication with coin cell device. The resulting membrane was then characterized by Scanning Electron Microscope (SEM) and Fourier Transform Infrared (FTIR). For the result of supercapacitor fabrication with coin …
Simulation Of Magnet Thickness And Angle Of Attack On Magnetic Force For Magnetic Turbine Design, Eka Pratama, Wirawan Wirawan
Simulation Of Magnet Thickness And Angle Of Attack On Magnetic Force For Magnetic Turbine Design, Eka Pratama, Wirawan Wirawan
Journal of Mechanical Engineering Science and Technology (JMEST)
Electric motors play a vital role across various industries. As their electricity demand grows, improving efficiency has become a priority. One area of innovation involves the use of magnetic strips for improving performance. This study aims to determine the magnet thickness and the angle of attack position in producing the strongest repulsive force in the magnetic turbine. The study used a simulation using SOLIDWORKS and EMS software, applying neodymium N52 magnets with varying sizes and angles of attack. The results indicate that the most efficient magnetic turbine configuration utilizes rotor and stator magnets with dimensions of Ø10 × 20 mm …
Harnessing The Role Of Carbon Black: A New Frontier For Energy-Density Supercapacitor Electrodes, Ana Yuli Komariyah, Ishmah Luthfiyah, Ida Vaeruza Albadi’Ah, Nasikhudin Nasikhudin, Worawat Meevasana, Markus Diantoro
Harnessing The Role Of Carbon Black: A New Frontier For Energy-Density Supercapacitor Electrodes, Ana Yuli Komariyah, Ishmah Luthfiyah, Ida Vaeruza Albadi’Ah, Nasikhudin Nasikhudin, Worawat Meevasana, Markus Diantoro
Journal of Mechanical Engineering Science and Technology (JMEST)
The performance of activated carbon (AC)-based supercapacitor electrodes is often limited by poor electrical conductivity, prompting interest in conductive additives such as carbon black (CB). This study explores the transformative potential of CB as a conductive additive in AC-based supercapacitor electrodes and systematically investigates CB mass loadings of 0%, 5%, 10%, 15%, and 20%, using styrene-butadiene rubber (SBR) as the binder. The findings in this study demonstrate that 10% CB is the optimal loading, offering a balanced performance in terms of structure, morphology, and capacitance. X-ray diffraction (XRD) analysis reveals a distinct structural evolution at 10% CB, characterized by the …
Surface Analysis Of Bacterial Cellulose Membrane Made From Biowaste Added With Zno Nanopowder, Naufal Rizky Amasda, Heru Suryanto, Uun Yanuhar, Aminnudin Aminnudin, Fajar Nusantara, Quota Alief Sias
Surface Analysis Of Bacterial Cellulose Membrane Made From Biowaste Added With Zno Nanopowder, Naufal Rizky Amasda, Heru Suryanto, Uun Yanuhar, Aminnudin Aminnudin, Fajar Nusantara, Quota Alief Sias
Journal of Mechanical Engineering Science and Technology (JMEST)
Utilization of pineapple biowaste is important to increase the value added to biowaste and solve the environmental problem. So, the study objective is to synthesize membranes of bacterial cellulose made from pineapple biowaste and characterize the surface morphology and porosity of the membrane after being added with ZnO nanopowder. The study starts with extracting biowaste as a bacterial cellulose culture medium for the fermentation process. The obtained pellicle was crushed and homogenized with the added ZnO nanopowder in the presence of ultrasonic waves. The membrane is dried in the oven. The membrane morphology was monitored using scanning electron microscope and …
Collection Of Instructional Slides From Molten Salt Electrochemistry Symposium (Moses), Devin Rappleye, Carlos Mejia
Collection Of Instructional Slides From Molten Salt Electrochemistry Symposium (Moses), Devin Rappleye, Carlos Mejia
Faculty Publications
During the Molten Salt Electrochemistry Symposium (MoSES) on July 30-31, 2025, interactive instruction was given to the attendees including live demonstrations. These slides contain the introductory instructions given for each learning module at MoSES 2025. Please visit https://pyro.byu.edu/moses for more information.
Implications Of Palliative Care Education Amongst Critical Care Nurses And Applicable Screening Criteria For Consultation, Paiten Rask
DNP Projects
Background:
Palliative care is underutilized and/or consulted too late in the patient stay to provide optimal benefits to patients and families. There is a gap in nursing knowledge and confidence surrounding the topic of palliative care and the ability to advocate for specialty involvement for patients.
Objectives:
This project's purpose is to educate registered nurses in critical care about palliative care and introduce the idea of an objective palliative care screening tool. The project involved implementation of pre and post-test analysis of knowledge and confidence following a presentation of educational content. The content also included mock patient scenarios that require …
Unmasking The Heart Of Osimertinib: A Closer Look At Drug-Induced Cardiotoxicity, Muhammad Sabri, Aheed Javaid, Hussam Al Hennawi, Hamza Muhammadzai, Vamshi Mallavarapu
Unmasking The Heart Of Osimertinib: A Closer Look At Drug-Induced Cardiotoxicity, Muhammad Sabri, Aheed Javaid, Hussam Al Hennawi, Hamza Muhammadzai, Vamshi Mallavarapu
Abington Jefferson Health Papers
BACKGROUND: Osimertinib, a third-generation epidermal growth factor receptor tyrosine kinase inhibitor, is an effective therapy for epidermal growth factor receptor-mutated non-small cell lung cancer, but it has been associated with a higher incidence of cardiotoxicity.
CASE SUMMARY: A 91-year-old woman on osimertinib 80 mg daily presented with acute dyspnea and was found to have a newly reduced left ventricular ejection fraction of 30%. Coronary angiography excluded obstructive coronary disease. Osimertinib was discontinued, and guideline-directed medical therapy (GDMT) was initiated, resulting in left ventricular ejection fraction recovery to 60%. The patient was successfully rechallenged with osimertinib while continuing GDMT, without recurrence …