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Comparing Dosimetric Outcomes Of Static Imrt And Vmat In Accelerated Partial Breast Irradiation For Medially Located, Left-Sided Tumor Beds, Rani Jamil

Masters Projects

Abstract

Introduction: Accelerated partial breast irradiation (APBI) has emerged as a targeted alternative to whole-breast irradiation for early-stage breast cancer, particularly for patients with medially located, left-sided tumors. Static intensity-modulated radiation therapy (IMRT) and volumetric modulated arc therapy (VMAT) offer advanced dose conformity, yet no direct comparisons between static IMRT and VMAT have been conducted specifically for medially located, left-sided APBI, a uniquely challenging anatomical subgroup. This study evaluates dosimetric differences between static IMRT and VMAT plans to determine which modality provides superior target coverage and organ-at-risk (OAR) sparing in left-sided APBI.

Methods: Ten patients with medially located left-sided breast …

Fsec Meeting Minutes July 23, 2025, University Of Rhode Island Faculty Senate

Faculty Senate Executive Committee Minutes

No abstract provided.

Physical Activity Mediates Age Differences In Cognition Among Tsimane Forager-Horticulturalists, Phoebe E. Imms, Nikhil N. Chaudhari, Daniel Cummings, Daniel Eid Rodriguez, Giuseppe Barisano, Paul L. Hooper, M. Katherine Sayre, Edmond Seabright, Randall C. Thompson, M. Linda Sutherland, James D. Sutherland, Benjamin C. Trumble, Michael Gurven, Jonathan Stieglitz, Caleb E. Finch, Hillard S. Kaplan, Wendy J. Mack, Margaret Gatz, Andrei Irimia

ESI Publications

Background: The Tsimane and Moseten of the Bolivian Amazon are highly physically active and exhibit low rates of cognitive impairment and brain atrophy.

Methods: We use structural equation modelling to examine how their physical activity levels mediate the relationship between (1) age and cognition, and (2) age and cognition via brain volume (BV).

Results: Tsimane males (n = 305, mean ± SD age = 59.94 ± 9.68) and Tsimane females (n = 265, mean ± SD age = 59.28 ± 9.79) exhibit significantly higher levels of physical activity than Moseten males (n = 106, mean ± SD …

Ibrutinib In Combination With Lenalidomide Revlimid/Dexamethasone In Relapsed/Refractory Multiple Myeloma (Aft-15)., Yvonne Efebera, Vera Suman, Shira Dinner, Taylor O'Donnell, Ashley Rosko, John Mckay, Peter Barth, Patrick Hagen, Saad Usmani, Paul Richardson, Jacob Laubach

Oncology Articles

BACKGROUND: Studies have suggested a synergism between lenalidomide (LEN) and ibrutinib (IBR) in multiple myeloma (MM). Both downregulate IRF4, a key target and master transcriptional factor regulating myeloma cell survival.

METHOD: A 3 + 3 phase I trial was conducted to determine the maximum tolerated dose (MTD) of IBR in combination with LEN + dexamethasone (DEX) in patients with relapsed/refractory (RR) MM who had at least one prior line of therapy. Three dose levels (DLs) were planned. The cycle length was 28 days. IBR was administered orally daily in doses of 560 mg on DL1-2 and 840 mg on DL3, …

Optimizing Tobacco-Free Workplace Programs: Applying Rapid Qualitative Analysis To Adapt Interventions For Texas Healthcare Centers Serving Rural And Medically Underserved Patients, Hannah Wani, Maggie Britton, Tzuan A Chen, Ammar D Siddiqi, Asfand B Moosa, Teresa Williams, Kathleen Casey, Lorraine R Reitzel, Isabel Martinez Leal

Faculty, Staff and Student Publications

Background: Tobacco use is disproportionately high in rural areas, contributing to elevated cancer mortality, yet it often goes untreated due to limited access to care, high poverty and uninsured rates, and co-occurring substance use disorders (SUDs). This study explored the utility of using rapid qualitative analysis (RQA) to guide the adaptation of a tobacco-free workplace program (TFWP) in Texas healthcare centers serving adults with SUDs in medically underserved areas.

Methods: From September-December 2023 and May-July 2024, we conducted 11 pre-implementation, virtual semi-structured group interviews focused on adapting the TFWP to local contexts (N = 69); 7 with providers (n …

Conditional Optimal Sets And The Quantization Coefficients For Some Uniform Distributions, Evans Nyanney, Megha Pandey, Mrinal Kanti Roychowdhury

School of Mathematical & Statistical Sciences Faculty Publications

Bucklew and Wise (1982) showed that the quantization dimension of an absolutely continuous probability measure on a given Euclidean space is constant and equals the Euclidean dimension of the space, and the quantization coefficient exists as a finite positive number. By giving different examples, in this paper, we have shown that the quantization coefficients for absolutely continuous probability measures defined on the same Euclidean space can be different. We have taken uniform distribution as a prototype of an absolutely continuous probability measure. In addition, we have also calculated the conditional optimal sets of n-points and the nth conditional quantization errors …

Teaching In Authentic Ways: Exhibit Work And Student Curators In Special Collections, Rebecca Fitzsimmons

Faculty and Staff Publications – Milner Library

Engaging students in exhibit work offers them a chance to learn new skills and grow as scholars while producing a tangible and public-facing project outcome from their coursework. From learning to communicate complex ideas to making research connections between rare and primary sources, exhibit curation relies on building research skills, sharpening writing and communication techniques, and developing critical thinking skills. Pushing and refining ideas is an essential part of the iterative process of research, and exhibit curation invites students to learn this practice in a real-world, project-based way. More specifically, it requires students to read, review, compare, and analyze more …

Insights From The Front Line: Uplifting Stories Of The Covid-19 Pandemic Through The Eyes Of The Public Health Workforce In Iowa, Heidi Haines, Amanda Sursely, Hanh Pham, Rylee Beltran, Daniel K. Sewell, Lina Tucker Reinders, Natoshia Askelson, Sarah Dixon, Kaitlin Emrich, Christine Estle, Michelle Lewis, Jimmy Reyes

Faculty Publications

Introduction: SARS-CoV-2 was declared a pandemic in March 2020. Studies have characterized some of the negative impact of the pandemic on public health workers (PHW), but few have explored the strength and coping strategies used. Our study documents the experiences of PHW in Iowa during the pandemic. Methods: We used an innovative mixed methods data collection tool, SenseMaker^® to gather stories from PHW in Iowa between March and July 2022. Participants provided additional data about their story via structured follow-up questions. We conducted descriptive analyses of the quantitative questions. A qualitative thematic and sentiment analysis was applied to all …

Effects Of Oxygen Manipulation On Myofibroblast Phenotypic Transformation In Patients With Radiation-Induced Fibrosis, Eric Mastrolonardo, Sarah Sussman, Bo Yun, Victor Jegede, Dev Amin, Joel Rosenbloom, Andrew P. South, Voichita Bar-Ad, Peter J Wermuth, Adam J. Luginbuhl

Department of Otolaryngology - Head and Neck Surgery Faculty Papers

We tested if hyperoxic conditions can reduce the proportion of active myofibroblasts, which are assumed to be a major driver of head and neck radiation-induced fibrosis, as measured by expression levels of pro-fibrotic genes. Radiated, non-cancerous soft tissue from the head and neck and skin/soft tissue from non-radiated flap donor site were collected from each patient. Myofibroblast density was quantified using immunofluorescence staining with α-SMA and DAPI and visualisation under confocal microscopy and compared between baseline non-radiated and radiated tissue from the same patient. From each tissue specimen, fibroblast cell lines were cultured and exposed to either normoxic, hypoxic, or …

Re: Comments On The Repository, Haul Route, And Pipeline Geotechnical Pre-Design Investigation Summary Report (Dated May 13, 2025), Emma Rott

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Re: Comment Letter For The Draft Final Butte Priority Soils Operable Unit (Bpsou) 2022 Unreclaimed Sites Sampling: Ur-20 Site Evaluation Summary Report (Dated March 19, 2025), Molly Roby

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

The Microtubule-Severing Enzyme Spastin Regulates Spindle Dynamics To Promote Chromosome Segregation In Trypanosoma Brucei, Thiago Souza Onofre, Qing Zhou, Ziyin Li

Faculty, Staff and Student Publications

Microtubule-severing enzymes play essential roles in diverse cellular processes, including mitosis and cytokinesis, by modulating microtubule dynamics. In the early branching Trypanosoma brucei, microtubule-severing enzymes are involved in cytokinesis and flagellum length control, but none of them have been found to regulate mitosis. Here we report the characterization of the microtubule-severing enzyme spastin in the procyclic form of T. brucei. We demonstrate that spastin severs microtubule in vitro and overexpression of spastin disrupts spindle microtubules in vivo in trypanosomes, leading to defective chromosome segregation. Knockdown of spastin impairs spindle integrity and disrupts chromosome alignment and segregation. We further show that …

Lessons From The 2023 Ieee Autonomous Drone Chase Challenge, Luigi Raphael I. Dy, Kristoffer B. Borgen, John H. Mott, Yung Hsiang Lu, Li Yu Lin, Zhangpeng Yang, James M. Goppert, Jakub Tomczak, Stefano Roccella, Andrea Vannini, Zhiwei Dong

Faculty Research, Scholarly, and Creative Activity

No abstract provided.

Ai Regulation: Competition, Arbitrage & Regulatory Capture, Filippo Lancieri, Laura Edelson, Stefan Bechtold

Georgetown Law Faculty Publications and Other Works

The commercial launch of ChatGPT in November 2022 and the fast development of large language models have catapulted the regulation of artificial intelligence to the forefront of policy debates. A vast body of scholarship, white papers, and other policy analyses followed, outlining ideal regulatory regimes for AI. The European Union and other jurisdictions have moved forward by regulating AI and LLMs. One overlooked area is the political economy of these regulatory initiatives—or how countries and companies can behave strategically and use different regulatory levers to protect their interests in the international competition on how to regulate AI.

This Article helps …

Story Forge: A Card-Based Framework For Ai-Assisted Interactive Storytelling, Yaojiong Yu, Gianni Corino, Mike Phillips

School of Art, Design and Architecture

The application of artificial intelligence has significantly advanced interactive storytelling. However, current research has predominantly concentrated on the content generation capabilities of AI, primarily following a one-way ‘input-direct generation’ model. This has led to limited practicality in AI story writing, mainly due to the absence of investigations into user-driven creative processes. Consequently, users often perceive AI-generated suggestions as unhelpful and unsatisfactory. This study introduces a novel creative tool named Story Forge, which incorporates a card-based interactive narrative approach. By utilizing interactive story element cards, the tool facilitates the integration of narrative components with artificial intelligence-generated content to establish an interactive …

Rishon Le-ẒIyyon, Winepress Park: Geomorphology And Sedimentology, Joel Roskin, Yotam Asscher

Qadum: Journal of Excavation Reports from Israel

An extensive brown sandy double-unit sediment, draping large parts of the archaeological remains at the Winepress Park in Rishon Le-Ẓiyyon, is suggested to be associated with the previously reported, undated ʻEn Ha-Qore clay. Based on relative age port-OSL profiling, the depositional mechanism of this unit and the overlying sand is suggested to be related to late Holocene, dune-dammed winter ponds. These aeolian-fluvial dune-damming processes may have been partly triggered by intensive Byzantine human activity that may have led to sand mobilization.

Humanization Strategy Of The Public Urban Space In Cairo, Rania Badawy Shokry

Mansoura Engineering Journal

An accurate scientific definition of the term “humanization of cities” has not yet crystallized, which refers the term to the word from which it is derived. She is "human". Obviously, anything contrary to it is inhuman; starting from wild nature or a life entirely dependent on vehicles. If a person cannot dispense with vehicles when carrying out his daily activities, then here we know that the standard of humanization in a place is low. However, if the planning of a city or neighborhood takes into account the needs of the population and the human standard, then the city may reach …

Essays On Freedom And Power, John Acton

Hannah Arendt Marginalia - All

New York : [Published by Noonday Press], 1955, [c1948]

Call #: New York : JC571 .A14 1955

Excerpted pages contains marginalia, underlining and marginal lining

PDF Information: 77 pages – 4.5 MB

Effects Of Plasma-Activated Water On Wheat: Germination And Seedling Development, Wafaa Abdulrazzaq Abdullah, Hadeel O. Ismael, Duaa A. Uamran, Hammad R. Humud

Karbala International Journal of Modern Science

The food sector must contend with issues such as pathogen resistance to some of the available chemical agents, environmental pollution, and climate change to provide healthy food for livestock and people. The application of atmospheric pressure plasma jets (APPJs) is one potential solution for such problems. Plasma is appropriate for effective surface decontamination regarding food products and seeds, surface decontamination, and achieving improved agricultural production yields. The impact of plasma-activated water (PAW) produced by plasma jet discharge (PJD) system on in vitro-cultivated wheat seeds is examined in this work. For this aim, a plasma jet system was constructed with a …

Novel Suclg1 Variants In A Patient With Fatal Neonatal Onset Succinyl-Coa Ligase Deficiency, Devlynne S. Ondusko, Lauren Culbertson, Cary O. Harding, Cori Feist, Johan L.K. Van Hove, Marisa W. Friederich, Sacha Ferdinandusse, Roxanne A. Van Hove, Jonathan N. Pruneda, Brian Scottoline, Kimberly A. Kripps

Journal of Pediatric Genetics

Succinyl-CoA ligase deficiency is a rare autosomal recessive enzymatic deficiency that causes an energy-deficient state with mitochondrial depletion syndrome. It is often fatal. We present a case of novel variants in SUCLG1 leading to fatal infantile lactic acidosis. Two variants of uncertain significance in trans were identified in SUCLG1: c.901G>A p.(Gly301Arg) paternally inherited and c.532-6T>A maternally inherited. These variants resulted in severely reduced succinyl-CoA ligase activity. This patient exhibited the classical metabolic profile of succinyl-Co-A ligase deficiency and massive elevation of glutamine. Elevated glutamine, in the absence of hyperammonemia, should lead providers to consider succinyl-CoA ligase deficiency in …

46,Xx Disorders Of Sex Development: A Case With P.Arg92trp Variant In Nr5a1, Mehmet Ali Oktay, Agah Akin, Esra Döğer, Gülsüm Kayhan, Gizem Eşme Kocaman, Mahmut Orhun Çamurdan, Aysun Bi̇deci̇

Journal of Pediatric Genetics

Ovotesticular (OT) disorders of sex development (DSDs) are marked by the simultaneous presence of ovarian and testicular tissues within the gonads. The appearance of external genitalia does not necessarily correlate with gonadal histology. Variants in the NR5A1 gene can result in SRY-negative DSD. In this report, we present a case involving a variant in the NR5A1 gene. A 3-year-old phenotypic male presenting with micropenis, penile hypospadias, and a bifid scrotum was identified to have a c.274C > T, p.Arg92Trp variant in the NR5A1 gene, along with a 46, XX karyotype. Genetic factors such as variants in the NR5A1 gene, independent of …

Egfr Mutation In Neonatal Nephrocutaneous Syndrome: Unveiling A Genetic Challenge, Manuela S. Lopes, Cátia Martins, Ana Ferraz, Joana Rosmaninho-Salgado, Rui Castelo, Joaquim Tiago, Leonor Ramos

Journal of Pediatric Genetics

Epidermal growth factor receptor (EGFR) is a transmembrane glycoprotein that exhibits tyrosine kinase signaling activity, playing a pivotal role in various cellular processes. Overexpression or overactivity of EGFR is significantly associated with inflammatory and malignant diseases, particularly lung cancer. Conversely, germline loss-of-function mutations in EGFR have been distinctly linked to a rare condition known as neonatal nephrocutaneous syndrome. We report a case of a preterm female neonate, born to consanguineous parents and from a pregnancy that was complicated by polyhydramnios. From birth, she displayed distinctive clinical features, including fragile skin and widespread erythema, sparse scalp hair, bilateral ankyloblepharon, thick eyebrows, …

The First Turkish Spondylocarpotarsal Synostosis Syndrome Case With Ventricular Septal Defect And Pelvicaliectasia Caused By A Novel Homozygous Frameshift Variation In Flnb, Esra Dirimtekin, Esra Arslan Ateş, Hamza Polat, Eda Almus, Bilgen B. Geckinli

Journal of Pediatric Genetics

Spondylocarpotarsal synostosis syndrome (SCT) (OMIM: 272460) is an autosomal recessive disorder characterized by block vertebrae, carpal-tarsal synostosis and disproportionate short stature. Some clinical characteristics of SCT are dysmorphic facial traits, cleft palate, hypoplastic tooth enamel, brachydactyly, clinodactyly, limited joint movement and mixed hearing loss. Biallelic nonsense and frameshift pathogenic variantions in FLNB gene are associated with SCT. An 8 -year -old patient was referred with a suspicion of skeletal dysplasia. He had short stature, scoliosis, carpal-tarsal synostosis and ventricular septal defect (VSD). Clinical exome sequence (CES) analysis was performed and a novel homozygous frameshift variation in FLNB (c.219_222dup p.Met75Profs*17) was …

Systematic Review About Clinical And Radiologic Manifestations In Patients With Fatco Syndrome, D’Karlo Yosue Dongo Cornejo, Wendy Alessandra Gutiérrez Baca, Maria Cristina Laso Salazar, Hugo Hernán Abarca-Barriga

Journal of Pediatric Genetics

FATCO syndrome (Fibular Aplasia, Tibial Camptomelia, Oligosyndactyly) is characterized by the presence of Fibula Aplasia, Tibial Campomelia and Oligosyndactyly. It is an autosomal dominant congenital genetic disorder, with an infrequent occurrence. This is the main reason behind the limited number of studies carried out to date, and the importance of carrying out this review to enhance the understanding of this syndrome. The objective of this review based on case reports is to describe and analyze the clinical and radiological characteristics of patients diagnosed with FATCO syndrome, in addition to demographic characteristics and concomitant anomalies. The databases used in this review …

Sleep Disordered Breathing In Children With Achondroplasia: 17 Years’ Experience From A Multidisciplinary Team, Maria Jose Guerdile, Virginia Fan, Mariana Del Pino, Vivian Leske

Journal of Pediatric Genetics

The aim of this study was to describe sleep-disordered breathing (SDB) and treatment in children with achondroplasia (ACH). A retrospective longitudinal study was conducted at the Sleep Unit, Hospital de Pediatría Garrahan. Children with ACH, aged 0 to 18 years, referred for SDB due to clinical symptoms or foramen magnum stenosis (FMS) with at least one polysomnography (PSG) between 2002 and 2019 were included in the study. The primary outcomes included SDB typification and therapeutic interventions. We included 89 patients; 79.7% had one PSG, 13.4% had two PSGs, and 5.6% had three PSGs. The first PSG confirmed SDB in 65.16% …

Opportunities For Growth: A Metacognitive Self-Talk Strategy That Improves Classroom Unity And Academic Attitudes, Sera Anello, Michael J. Haslip

Journal of Practitioner Research

This teacher action research study describes the development and application of the opportunities for growth teaching method to increase learner motivation, persistence, cooperation and positive self-talk among primary school students. The approach was implemented with 30 fourth graders in a Philadelphia public school classroom to foster unity, support attitudes toward academics and participation, redefine failure, and reframe challenges. Before this intervention, most of the students lacked self-regulation, self-awareness, and relationship skills needed to thrive. This study investigates how and to what effect the opportunities for growth approach shifts students’ language and mindset about academic and social challenges. Qualitative data was …

Teaching Ai Ethics And Skepticism: The Impact Of Instruction On Ethical Usage On Students’ Perceptions, Jenna D. Justin

Journal of Practitioner Research

This study investigates the ethical implications of artificial intelligence (AI) in K-12 education, focusing on how explicit instruction influences students' perceptions of AI tools like ChatGPT. Conducted with 80 sixth-grade students at A.D. Henderson University School and FAU High School, the research tracks changes in student understanding and skepticism of AI following a World History unit. Pre- and post-instruction surveys revealed a decline in comfort with AI as students became more aware of its ethical concerns, including plagiarism, bias, and misinformation. The findings suggest integrating AI ethics into the middle school curriculum to foster responsible AI usage among students.

Expanding The Role Of Embodiment And Teacher Noticing In Units Coordination And Construction, Claudia Bertolone-Smith, Jonathan Troup, Liza Bondurant, Diana Moss, Hortensia Soto

Journal of Practitioner Research

We aim to expand units coordination and construction assessment by examining the significance of embodiment and teacher noticing, especially in relation to recent developments in equitable mathematics teacher noticing research. We outline our approach as mathematics teacher educators with a wide range of expertise, wherein we investigated how prospective elementary mathematics teachers (PTs) notice students' units construction and coordination through embodied actions and the impact of incorporating a focus on embodiment in assessment. We also address how expanding the understanding of units coordination and construction assessment through embodied noticings can create more equitable classroom spaces. The study emphasizes the need …

Enhancing 5g Non-Terrestrial Network (Ntn) Communications With Machine Learning-Driven Non-Line-Of-Sight (Nlos) Prediction And Mitigation, Alwin Xavier, Wojciech Grobel, Snezana Mitrovic, Vinay Saini

Defensive Publications Series

The innovation proposed herein leverages machine learning to predict Non-Line-of-Sight (NLOS) conditions in a 5G Non-Terrestrial Network (NTN), significantly enhancing communication reliability in such networks. By dynamically encoding these predictions into user equipment (UE) Route Selection Policies (URSPs), the innovation proposed herein optimizes data transfers, ensuring efficient use of satellite coverage and improving overall network performance with minimal changes to the existing 5G core infrastructure.

Enterobacter Cloacae As A Rare Cause Of Cerebral Abscesses In A Neonatal Late-Onset Sepsis – A Case Report And Literature Review With Focus On Risk Factors, Diagnostics And Treatment, Yıldız Yıldırım, Ruy Perez, Rüdiger Wentzell, Clemens Andrée, Martin Weinzierl, Norbert Utz, Tim Niehues

Journal of Pediatric Infectious Diseases

Late-onset sepsis (LOS; sepsis occurring after the first 72 hours of life) increases the morbidity and mortality of premature neonates, especially those with very-low-birth weight (≤1500g). In LOS, Enterobacter cloacae has been rarely described as a cause of secondary brain abscesses. Our case report summarizes important aspects of cerebral abscesses due to an E. cloacae sepsis in a preterm neonate. Our patient received surgical abscess drainage and rational antibiotic treatment employing prolonged meropenem infusions plus fosfomycin and subsequent treatment with oral trimethoprim/sulfamethoxazole. Furthermore, we present a review of the current literature from 2009-2022, comparing cases similar to our case.