Digital Commons Network^™

Gboost-Ctl: A Novel Method In Multi-Tissue Transcriptome-Wide Associations Studies In Cross-Tissue Learner Incorporating Gwas Information, Md Mutasim Billah, Hairong Wei, Fengzhu Sun, Kui Zhang

Michigan Tech Publications

Genome-wide association studies (GWAS) have uncovered numerous genetic variants linked to complex human diseases, yet linking these variants to transcripts and tissues that drive pathology remains difficult. Multi-tissue transcriptome-wide association studies (TWAS) offer a powerful bridge, but existing analytical methods have some limitations, either by discarding important signals by separately analyzing and then aggregating results across tissues, implying imputation models in individual tissues, or fusing them with weights that ignore how much GWAS signal each tissue actually carries. Therefore, most of the existing methods do not work uniformly across different GWAS cohorts. Here, we propose GBoost-CTL - a GWAS-boosted cross-tissue …

Analysis And Interpretation Of Somatic Nmd-Escaping Variants In Oncogenes And Dual-Function Genes Across Adult And Pediatric Cancer Cohorts, Runjun D Kumar, Jiaming Li, Mark R Wilkinson, Lu Wang, Jeffery M Klco, Li Tang, Jennifer L Neary, Sharon E Plon, Patrick R Blackburn

Faculty, Staff and Students Publications

Interpreting protein-truncating variants predicted to escape nonsense-mediated decay (NMDe) based on the 50-bp rule is challenging due to their variable consequences. The Clinical Genome Resource, Cancer Genomics Consortium, and Variant Interpretation for Cancer Consortium recommendations focus on tumor suppressor genes where NMDe variants may result in loss-of-function. However, guidance for interpreting NMDe variants in oncogenes and dual-function genes remains limited. To address this gap, we screened the Catalogue of Somatic Mutations in Cancer, focusing on oncogenes and dual-function genes with ≥10 NMDe variants supported by published functional studies. This analysis prioritized 15 genes exhibiting two distinct NMDe patterns resulting in …

Timeless Poetry, Xuning Li

Theses

Timeless Poetry reimagines classical Chinese poetry through contemporary digital tools, transforming ancient verse into immersive visual experiences. Using Cinema 4D and Blender for 3D modeling and ink-wash–inspired rendering, the project reconstructs poetic landscapes as cinematic-style environments that invite viewers to encounter traditional imagery through modern visual language. Postcards—chosen for their nostalgic and emotional resonance—serve as both a physical anchor and an interactive trigger: when scanned, each card reveals an AR visuals that reveal the scene in motion. This hybrid design bridges past and present, showing how technology can enhance, rather than replace, cultural heritage by offering new entry points for …

A Journey Into The Mysterious Quantum Realm, Kien Bui

Osmosis Magazine

Toward the end of the 18th century, many scientists believed that all the fundamental laws of physics had already been discovered. Falling apples obeyed Newton’s laws of motion, spinning compasses were explained by Maxwell’s unification of electricity and magnetism, and steam engines drove the first industrial revolution through the rise of thermodynamics. Lord Kelvin stated, “[t]here is nothing new to be discovered in physics now, all that remains is more and more precise measurement.” Only “two small clouds,” he warned, were the two remaining mysteries: black-body radiation and the theory of light. These small clouds, however, turned out to be …

From Sci-Fi To Reality: Could There Be Life On Mars?, Matea Šarkinović

Osmosis Magazine

Have you ever wondered: Are we alone in the universe? Well, scientists hope to answer the age-old question and they believe that Mars could hold the answer. The red planet has been identified as a potential home to life beyond Earth, and this article aims to explore what makes Mars such a strong candidate. Understanding the conditions on extraterrestrial objects is key to determining if our existence is a unique phenomenon or if we are the product of a recurring event that happens throughout the universe.

True Silver: A Story Of Skin Coining With Silver In Traditional Asian Medical Practice, Trang Nguyen

Osmosis Magazine

Silver, one of the most precious metals on Earth, has captivated humans since prehistoric times for its natural shimmer, which has found its way into coins, jewelry, and ornaments (The Natural Sapphire Company, 2025). In traditional Asian medicine, silver’s significance extends beyond jewelry or currency; it is a key component in a practice called “cạo gió”, which involves releasing energy blockages and restoring balance to the body using a smooth metal tool to scrape the skin. Although it has been passed down through generations as a remedy for various ailments, a question remains: what makes silver the material of choice?

Spicomellus The Jurassic Enigma, Bryan Nam

Osmosis Magazine

Imagine stepping into a time machine and messing with the controls until you find someplace interesting to go. Your destination? Morocco, 165 million years ago. You arrive and look around at vast floodplains stretching far across the horizon; flat land cut through by mighty rivers. In the distance, you see something, a creature unlike any you’ve ever seen before. It looks straight out of a sci-fi movie. It seems almost like a reptilian tank, with huge spikes on its neck and hips. The dinosaur looks towards you, then turns away to look for food. You have just come face to …

Let’S Talk About Birds Baby: How Did Birds Evolve To Have Such Elaborate Courtship Rituals?, Lautaro Lo Prete

Osmosis Magazine

If you’ve ever watched a nature documentary featuring David Attenborough, you’ve definitely marveled at the eccentric and complex rituals of some bird’s courtship display. This behavior is a phenomenon among birds where males will often complete a ritualistic dance as a way to attract a female. But why go through all the hassle? What is the purpose of expending so much energy— all the while putting yourself at such a heightened risk of predation?

Chew On This How Gum Can Prevent Cavities, Garrett Mayover

Osmosis Magazine

Gum has become a staple in my daily routine. What started as something I chewed casually after school has evolved into a small yet essential part of how I relax, focus, and stay alert throughout the day. Beyond its familiar chewy texture and refreshing flavors, gum has a surprising hidden benefit - it can actually help prevent cavities. This article will explore what gum really is, the science behind its cavity-fighting abilities, and which types of gum are best for maintaining a healthy smile.

To Q-Tip Or Not To Q-Tip, Ainsley Coleman

Osmosis Magazine

If you are one of the many people on this earth lucky enough to have wet earwax and use earbuds, you have likely experienced some sort of discomfort at some point in your ears. Maybe it’s a slight itch, or a feeling of build-up, and so you reach for a q-tip. And, maybe as you reach for that cotton swab, you feel nagged by a reminder that q-tips are not to be put in your ears! But still, you use one to relieve that discomfort.

Osmosis.

Osmosis Magazine

Science Magazine

Earth’S Orbital Prison: Codifying Customary Law To Prevent Environmental Catastrophe In Space, Jacob Cook

Space and Defense

This article argues that the accelerating proliferation of space debris in low Earth orbit (LEO) poses an existential threat to the sustainability of the orbital environment—one comparable in strategic gravity to nuclear deterrence during the Cold War. Drawing on liberal internationalist theory and the concept of Mutually Assured Destruction (MAD), the paper asserts that deliberate satellite destruction through anti-satellite (ASAT) testing and negligent debris generation risk triggering a self-sustaining cascade of collisions known as the Kessler Syndrome. Existing treaties, including the Outer Space Treaty and the Artemis Accords, lack enforceable mechanisms to prevent such catastrophic harm. To fill this …

In Defense Of Space Offense, Alexander R. Kleitz

Space and Defense

This article argues that in the unique physical and operational environment of outer space, offensive operations hold intrinsic advantages over defensive ones. Drawing upon classical military theorists such as Clausewitz and Corbett, the author contends that the traditional dominance of the defensive form of war—rooted in terrestrial conditions—does not extend to celestial conflict. The transparency and remoteness of the space domain neutralize key defensive benefits, such as proximity to supply bases, concealment, and fortified positions, while also diminishing the factors that typically cause terrestrial offensives to culminate. Consequently, space conflict favors the side that seizes and maintains the initiative through …

Space And Defense Vol. 16 No. 2 Front Matter, Editors Space And Defense

Space and Defense

No abstract provided.

Space & Defense Volume 16 Issue 2 Fall 2025 (Whole Issue), Editors Space And Defense

Space and Defense

No abstract provided.

Hidrotuango: Understanding The Reach Of Cascading Risk, Juan Guevara, Rob Shields

Fast Capitalism

No abstract provided.

Frantz Fanon / Immanuel Wallerstein: Marxism, Capitalism, And The Now Uncertain World, Charles Lemert

Fast Capitalism

No abstract provided.

Full Issue, Fast Capitalism Editorial Team

Fast Capitalism

No abstract provided.

“This Is The New Normal?” Restoring Or Restricting Democracy Today In America, Timothy W. Luke

Fast Capitalism

No abstract provided.

Populism In The Technospheric, Jamie Ranger

Fast Capitalism

I argue that the technospheric condition - a socio-technical reality shaped by social acceleration, the industrialization of memory, and mediatization - serves as a structural catalyst for the repoliticisation of the status quo, necessitating a rethinking of Ernesto Laclau’s discursive approach to populism. Drawing on insights from Bernard Stiegler, Hartmut Rosa, and others, I characterize contemporary social life as deeply entangled with technospheric forces, which exacerbate social problems and provoke counterhegemonic responses. These responses, politically solidified in both emancipatory and reactionary populisms, are not only shaped by populist strategy but also increasingly influenced by algorithmic steering on social media. Thus, …

Trump Redux: Immigration, Indigeneity, And America, Nancy S. Love

Fast Capitalism

No abstract provided.

Still Making It Up As He Goes: Revisiting The Hyper-Rhetorical Presidency In Trump’S Second Term, Richard Holtzman

Fast Capitalism

No abstract provided.

Digital Competence In Early Childhood Formal And Informal Education: Findings From A Systematized Review, Davide Cino, Claudio D’Antonio, Federica Ranzani, Silvia Demozzi, Cosimo Di Bari

Journal of Media Literacy Education Pre-Prints

This article reports on findings from a systematized literature review on digital competence in early childhood (age range, 0-6). Through a quantitative and qualitative analysis of 31 empirical studies, the article provides: 1) a mapping of key information contained in the dataset based on relevant variables inductively and deductively identified (i.e., children’s age, type of educational context, type of digital skill, caregiving actors, description of relevant activities, screen time discourse, risks and opportunities discourse, reference to wellbeing); and 2) a narrative in depth account of digital competence in early childhood in relation to the type of educational context investigated, i.e., …

The Student Movement Volume 110 Issue 9: Admiring Art And Catching The Bus, Melanie Webb, Michael Orellana, Megan Constantine, Gersh William, Ysa Dennis, Samantha Woolford-Hunt, Madison Vath, Sophia Koh, Ysabella Neves, Kara Shepard

The Student Movement V. 110 (2025-2026)

ARTS & ENTERTAINMENT

Creating AU's Artful Atmosphere: the AU Art Club, Melanie Webb

Rachel Barton Pine To Perform at HPAC, Michael Orellana

Gestures of Creation: Greg Constantine's Abstract Genesis, Megan Constantine

HUMANS

Committed to Communication: Prof. Walker-Fraser on Educating, Gersh William

NEWS

SILA To Host Annual Winter Wonderland, Ysa Dennis

IDEAS

Where Has All the Color Gone?, Samantha Woolford-Hunt

Grad School Apps Are Not Easy, Michael Orellana

PULSE

Dorm Decor: Winter Edition, Madison Vath

Hot Chocolate: The Perfect Holiday Tradition, Sophia Koh

Survey: Architecture Students Speak Out on Heavy Workload and 'Huge Troll' on Well-Being, Ysabella Neves

LAST WORD

The …

Ideas For Learning Newsletter: Late November ‘25, Iwasaki Library

IDEAS for Learning Newsletters

This IDEAS for Learning newsletter reached faculty of Emerson College on November 21st, 2025. This is the second published issue of the two total issues that were published within the month of November. This is the eighth issue of the 3rd volume. It includes upcoming events like a faculty workshop on engaged and praxis-based pedagogy with Tuesda Evans, Course Spa, a spotlight feature congratulating the department of Communication Studies, support for your teaching with a reminder about teaching hub drop-in hours, assessment chats with OAA, a Liberal Arts at Emerson survey, resources like a reminder about submitting course reserves, what …

Antidepressant Use In Older Age Bipolar Disorder (Oabd): Results From The Gage-Bd International Consortium, P. J. Chen, Lisa T. Eyler

Faculty Scholarship

Background Antidepressants are still commonly prescribed in bipolar disorders, despite ongoing controversy of the potential risk of inducing hypomania/mania. There is limited knowledge about the characteristics of antidepressant use in older age bipolar disorder (OABD; age ≥50) in the current literature. Aim To describe antidepressant use, sociodemographic and clinical correlates of a global sample of OABD individuals. Methods The Global Aging and Geriatric Experiments in Bipolar Disorder (GAGE-BD) consortium provided cross-sectional international data on OABD individuals ( n = 746) and younger-age bipolar disorder (YABD, age <50 years; n = 692) regarding antidepressant use. Multivariate logistic regression was employed to assess the association between AD use with demographic and clinical variables. Results Of 1252 participants, 33.1 % of OABD individuals and 38.1 % of YABD individuals were using antidepressants. In multivariable models among OABD, antidepressant use was associated with BD type II (OR = 1.61, 95 % CI: 1.09–2.38), higher depression severity (mild-to-moderate: OR = 1.86, 95 % CI: 1.13–3.06; severe: OR = 4.23, 95 % CI: 2.38–7.50), lower YMRS scores (OR = 0.93, 95 % CI: 0.89–0.97), female sex (OR = 1.37, 95 % CI: 1.00–1.89), lower education (OR = 0.61, 95 % CI: 0.43–0.86), and being unemployed (OR = 0.69, 95 % CI: 0.50–0.96). Antidepressant monotherapy was reported in 18 % of OABD users ( n = 46) and 19 % of YABD users ( n = 51). These findings suggest that both clinical severity and sociodemographic characteristics influence antidepressant prescribing in OABD. Conclusion Antidepressant use was less prevalent in OABD compared to YABD, and associated with female sex, lower education, lack of occupation, type II BD, higher depression severity and lower mania scores. In OABD, antidepressants appear to be used more commonly in contexts where they may be clinically more indicated, such as increased depression severity.

Doc 2025-21 Integrity In Research And Scholarship Policy, University Of Dayton. Faculty Affairs Committee

Senate Documents

In collaboration with the Office of Academic Research, and to support University compliance

with new regulations applicable to federally-funded research, the Faculty Affairs Committee

proposes adoption of the attached Integrity in Research and Scholarship Policy, which will

supersede Senate DOC 2014-07 Revisions to the Policy on Misconduct in Research and

Scholarship.

Mobility Disrupted: Geospatial Analysis Of Accessibility On The Mbta’S Orange And Red Lines Using Generalized Linear Poisson Regression, Maura Forde

Geography and the Environment: Graduate Student Capstones

This research analyzes the spatiotemporal relationship between explanatory variables and the frequency of downed elevator/escalator alerts at train stations on the Massachusetts Bay Transportation Authority’s (MBTA) Orange and Red lines. The data is from 2023. The null hypothesis is that there is no spatiotemporal pattern to the frequency/distribution of alerts. Generalized Linear Poisson Regression is used to model relationships across four time periods – the entire 2023 calendar year, Spring (January-April), Summer (May-August), and Fall (September-December). Results indicate that the null hypothesis can be rejected for all variables in Summer and Fall models but cannot be rejected for all variables …

The Effectiveness Of The Javanese Kickfun Game (J-Kig) As A Medium For Introducing Wayang Kulit To Teenagers, Antonio Tri Wibowo, Servatia Mayang Setyowati, Yulius Agung Saputro, Febri Sulistiya, Alimatus Sahrah

Jurnal Keolahragaan

Wayang kulit is a Javanese cultural heritage that is full of moral and philosophical values, but adolescents' interest in it is decreasing. Therefore, an innovative approach is needed to reintroduce wayang kulit to the younger generation. This study aims to test the effectiveness of the Javanese Kickfun Game (J-KIG) in introducing puppetry to adolescents. The method used was a quasi-experiment with a one group pretest-posttest design. The research sample consisted of 14 adolescents from Pundong 1, Sleman, Indonesia. The instrument used was the J-KIG cognitive test, and the data analysis was carried out by the Wilcoxon Signed-Rank Test. The results …

Fostering Connection And Empowerment: Amplifying Women’S And Indigenous Voices Through Place-Based Education, Inclusive Narratives, And Empathy Building, Paige N. Jones

Dissertations

The diverse experiences, perspectives, and identities of people across groups shape history. Educators and heritage professionals bear the responsibility of teaching historical content in ways that ensure all feel represented, valued, and safe. Despite these aims, the experiences and contributions of women and Indigenous Peoples have long been underrepresented in social studies curricula and heritage programming.

This dissertation integrates two complementary studies that examine how harnessing the power of place and centering the narratives and oral histories of underrepresented groups can advance connection and empowerment through educational experiences. The first study utilized focus group interviews with educators and heritage professionals …