Digital Commons Network^™

Allogeneic Bone Marrow-Derived Mesenchymal Stem Cells For Parkinson's Disease: A Randomized Trial., Mya C Schiess, Jessika Suescun, Juan D Martinez-Lemus, Charles Green, Tia S Thomas, Mohammad Shahnawaz, Emily Tharp, Nikunj B Satani, Jerome G Saltarrelli, Christopher Adams, Marie-Francoise Doursout, Vanessa Thyne, Rula Abuamouneh, Elsa M Rodarte, Sean I Savitz, Timothy M Ellmore

Faculty, Staff and Student Publications

Background: Neuroinflammation contributes to Parkinson's disease (PD) progression and motor dysfunction. Allogeneic human mesenchymal stem cells (allo-hMSCs) may reduce neuroinflammation and improve motor symptoms.

Objectives: To evaluate the efficacy of repeated intravenous doses of 10 × 106/kg allo-hMSCs in improving motor symptoms in patients with PD (PwP).

Methods: In this phase 2, randomized, placebo-controlled trial (November 2020-July 2023), mild-to-moderate PwP received either three allo-hMSC infusions, one placebo followed by two allo-hMSC infusions, or three placebo infusions at 18-week intervals. Follow-up lasted 88 weeks. The primary outcome was a >70% posterior probability (PP) of a difference in the proportion of participants …

Unveiling The Interactions Between The Antibiotic Resistome And Microplastics Influenced By Trace Elements And Ppcps In Wastewater Treatment Plants, Tahira Tasneem Rahman

All Graduate Theses and Dissertations, Fall 2023 to Present

Antibiotic resistance is a growing global concern, and wastewater treatment plants play a critical role in controlling its spread. These facilities process water containing microplastics (small plastic particles), trace elements like copper and zinc, and chemicals from everyday products like pharmaceuticals and personal care products. Together, these pollutants may contribute to the survival and spread of bacteria containing antibiotic resistance genes, but their combined effects are not fully understood. This study investigated how these pollutants behave and interact in wastewater treatment plants using two approaches: direct monitoring of real treatment plants and controlled lab experiments using synthetic wastewater. Results showed …

Spatial Strategies For Restoring Native Biodiversity And Connectivity In Managed Landscapes Of The Upper Clutha Basin, New Zealand, Jessica Zuban

All Graduate Theses and Dissertations, Fall 2023 to Present

Across New Zealand and around the world, biodiversity is declining due to the widespread loss and fragmentation of native habitat. This is especially true in agricultural landscapes, where native habitats have been replaced by intensive land use. This research focuses on the Upper Clutha Basin in Central Otago, New Zealand that has been significantly altered over time by farming, development, and other human activities. As a result, only a small amount of native vegetation remains, and the region is well below the critical threshold needed to support healthy ecological systems.

This study investigates how native vegetation can be strategically restored …

Evaluating Energy Transition Winners And Losers: Are Algae Biofuels Desirable, Feasible, And Viable?, Michelle M. Arnold

All Graduate Theses and Dissertations, Fall 2023 to Present

Climate change, environmental degradation, finite resources, and the uneven distribution of energy access all points to an urgent need for a global energy transition. But making that transition responsibly requires more than enthusiasm for “green” solutions—it demands careful evaluation of which energy sources are truly worth investing in. This dissertation develops a practical decision-making framework to help policymakers, scientists, and the public answer three foundational questions about any new energy technology: Is it desirable? Is it feasible? Is it viable? By systematically weighing public narratives, biophysical constraints, and patterns of innovation, the framework aims to prevent wasted time, funding, and …

Improvisation Of Mands Using Augmentative And Alternative Communication, Lauren Decker

All Graduate Theses and Dissertations, Fall 2023 to Present

Research shows that young children who use pictures to communicate can use colors, shapes, and functions of items to request when the specific picture of the item is not available. This problem-solving skill is called improvisation, which this study taught to a preschool aged participant with communication delays. A four-year-old preschool student was able to make these requests with basic colors, shapes, and three function pictures. They also were able to make these requests for items not taught to them in different settings. This suggests that improvisation training can be successfully implemented with preschool aged children with communication delays and …

An Evaluation Of Virtual Reality Modeling To Improve Accuracy Of Physical Education Skills In Teenage Students With Disabilities, Kristen Lee

All Graduate Theses and Dissertations, Fall 2023 to Present

Virtual Reality (VR) technology is becoming more common in schools, especially for teaching and training. In this study, researchers explored how VR can help teenagers with disabilities improve their physical education skills, specifically push-ups, lunges, and jumping jacks. The participants all showed an increase in their skills and reached a high level of accuracy on every skill. The results showed that adding feedback was also necessary for some participants. Additionally, participants enjoyed using the VR equipment and showed high levels of happiness throughout the study. These findings suggested that using VR technology can be an effective way to support teenagers …

Discourses Embedded In The Adams V. School Board Of St. Johns County Decision And The Rights Of Transgender Students In Schools, Douglas Larson

All Graduate Theses and Dissertations, Fall 2023 to Present

This study was critical analysis of the language of the court case Adams v. School Board of St. Johns County (2022). This case was brough by a student against the School District challenging a policy that prevented him, a transgender boy, from using the boys’ restroom. The analysis was not intended to determine the merits of the case or the correctness of the legal reasoning. Rather, the analysis was performed on the text of the case—the language used by the judges—to learn about the beliefs, attitudes, and values of the judges.

The reason this analysis is important is because judges …

The Effects Of Lactoferrin And Iron-Enriched Whey On Iron Status Of Collegiate Females, Connor Kemp

All Graduate Theses and Dissertations, Fall 2023 to Present

Iron deficiency has remained a global issue even in developed countries despite food fortification and increased nutritional literacy, biological women of child baring age are at particular risk due to menstruation and reduced dietary intake of iron containing foods compared to men. This issue is of particular concern in athletics due to the critical role of iron in oxygen transport and energy metabolism. With nearly half of female athletes presenting low iron status iron supplementation is often necessary. With iron supplementation often resulting in gastrointestinal symptoms that could negatively impact sport performance itself there is a need to explore other …

Developing Standardized Testing Datasets For Benchmarking Automated Quality Control Algorithm Performance With Aquatic Sensor Data, Ehsan Kahrizi

All Graduate Theses and Dissertations, Fall 2023 to Present

Advances in water monitoring technologies have led to a large increase in the amount of data collected from rivers, lakes, and other water systems. However, ensuring that these data are accurate and reliable remains a major challenge. Traditional data quality checks are done manually by a technician, which can be slow, inconsistent, and not practical for real-time monitoring. This research addresses these challenges by developing standardized datasets for testing computer-based methods that automatically detect and correct errors in water data. Using information from the Logan River Observatory in northern Utah, we created a step-by-step process to identify, categorize, and label …

Predicting Major Solar Flares Using Convolutional Neural Networks And Multivariate Magnetic Field Time-Series Data, Arash Azizian Foumani

All Graduate Theses and Dissertations, Fall 2023 to Present

Major solar flares are sudden, intense bursts of X-ray energy from the Sun, capable of severely impacting critical technological infrastructure like satellites, communication networks, and power grids on Earth. Accurate prediction of these high-intensity events is crucial but presents a significant challenge. This is largely due to their infrequent occurrence and the complex, dynamic nature of the Sun's underlying magnetic activity which drives these events. This research focuses on improving the prediction of major solar flares by utilizing detailed historical data that tracks the evolution of magnetic properties within solar active regions over time. This time-based data, however, contains inherent …

Cognitive Dynamics In Undergraduate Engineering Education: Effects Of Need For Cognitive Closure And Achievement Goal Orientation On Cognitive Engagement, Zain Ul Abideen

All Graduate Theses and Dissertations, Fall 2023 to Present

Cognitive and motivational factors play an important role in students’ engagement during problem-solving, which can lead to academic and professional success. Among these factors, Need for cognitive closure (NFCC) and achievement goal orientation (AGO) have been studied extensively individually, but their interaction and impact on engineering students’ problem-solving is still not explored. NFCC refers to the person’s desire for quick answers, and AGO is the student’s approach to learning and success. This research investigated the impact of NFCC on gender and engineering major, and the relation between NFCC (five facets) and AGO (Mastery, Performance) at their different levels. Additionally, this …

Enabling Scalable Camera-Based Streamflow Monitoring With Serverless Cloud Computing, Sajan Neupane

All Graduate Theses and Dissertations, Fall 2023 to Present

This thesis introduces a modern and automated method for monitoring rivers and streams using cameras and cloud-based software tools. Traditional monitoring methods often rely on sensors placed directly in the water, which can be expensive, hard to install, and difficult to maintain, especially in remote or rough terrain. In contrast, this approach uses cameras to observe water flow from a distance, offering a safer and more cost-effective alternative. However, camera systems come with their own challenges, such as collecting large amounts of image data, transferring it reliably from the field, and analyzing it quickly enough to be useful. This research …

Using Luminescence Of Quartz Temper From Archaeological Pottery To Infer Wildfire Intensity In The Southwestern Us, Brooklyn D. Dib

All Graduate Theses and Dissertations, Fall 2023 to Present

The size and frequency of wildfires have increased recently, impacting ecosystems, communities, and human health. This research uses the heat-sensitive luminescence signals of quartz sand temper within archaeological pottery to record past wildfire conditions. Pottery sherds, which are fragments of archaeological pottery, from the forest floor in sites in New Mexico and Arizona were collected from different fire contexts (no fire exposure, historical fires, prescribed burns, and modern wildfires). These forests are primarily Ponderosa Pine with a grassy understory. The interior sand grains of each sherd sample were analyzed using optically stimulated luminescence, which dates when the mineral grains were …

Quicklime-Based Self-Healing Concrete For Bridge Deck Applications, Mehrnoosh Nazari

All Graduate Theses and Dissertations, Fall 2023 to Present

Concrete is one of the most widely used construction materials in the world. However, over time, it can crack and deteriorate, especially on roads and bridges exposed to harsh weather and deicing salts. Inspired by the long-lasting durability of ancient Roman concrete, this study explores the self-healing capabilities of concrete incorporating quicklime (calcium oxide) aggregates to extend the service life of bridge decks. For this purpose, three concrete mixtures were developed using local materials: one without quicklime (C-Q 0%) and two with 2% (C-Q 2%) and 4% quicklime (C-Q 4%). These mixtures were tested for fresh properties, strength, durability, and …

Biocontrol Of Canada Thistle (Cirsium Arvense) With The Rust Fungus, Puccinia Punctiformis In The Intermountain West: Integrated Weed Management Compatibility And Characterization Of Microbiome Associations, Caitlin Henderson

All Graduate Theses and Dissertations, Fall 2023 to Present

Canada thistle (Cirsium arvense) is an invasive weed of major concern in both agricultural and native areas. It competes against native plants, reduces crop production and quality, and causes significant costs in management and damages. Canada thistle can survive and spread through seeds, but primarily does so through its extensive root system, which causes the greatest management difficulties. There are several control methods for this invasive weed, herbicides are perhaps the most common and effective, however, they have limitations and negative consequences. Herbicide use near waterways is restricted and there are growing concerns of the development of herbicide …

Assessing The Human Health Impacts Of Nutrient-Dense Diets: Clinical Trials On Regenerative Agriculture And Protein Source, Jennifer Jensen-Cloward

All Graduate Theses and Dissertations, Fall 2023 to Present

Increasing consumer demand for sustainable, animal-friendly food options has sparked discussion about farming production practices. As more people prioritize their food choices, questions have circulated about how farming practices might impact not just the environment, but also human health. Regenerative agriculture is a farming method that has gained popularity for its potential to improve both food quality and environmental outcomes. It focuses on restoring ecosystem function, ultimately impacting the resulting nutrients in food products, and includes foods like grass-fed meat and organic produce. However, it is still unclear whether these practices make a difference in human health. This dissertation informs …

Copyright Ownership And Duration Of Ai-Authored Works, Cheng Lim Saw

Research Collection Yong Pung How School Of Law

On the assumption that Parliament has endorsed the notion of AI authorship and the prospect that copyright may well subsist in works created autonomously by the AI itself, this essay further explores allied issues surrounding the ownership and duration of copyright in AI-authored works.

Reliability And Validity Of A Self-Administrated Online Assessment Of Intrinsic Capacity: A Singapore Cohort Study, Paulin Tay Straughan, William Tov, Lay Khoon Lau, Li Ling Grace Cheong, Chong Sheng Micah Tan, William Tov, Yew Yoong Ding, Wee Shiong Lim

Research Collection School of Social Sciences

Objective: To ascertain the construct validity and reliability of a self-administered web-based assessment of intrinsic capacity (IC). Design: Cross-sectional data analysis of a prospective cohort study. Settings and Participants: We included data from 6,434 respondents (age, mean (SD): 65.33 (5.81) years; 52.4% women) of the Singapore Life Panel population study who participated in the online surveys in March 2022 and May 2022.MethodsIncremental nested factor structures of IC were modelled with confirmatory factor analysis (CFA) and their goodness-of-fit were assessed mainly with root mean square error of approximation (RMSEA), comparative fit index (CFI), Tucker-Lewis index (TLI), and standardized root mean square …

Attachment To Artificial Intelligence: Development Of The Ai Attachment Scale, Construct Validation, And The Psychological Mechanisms Of Human-Ai Attachment, K Tennakoon Appuhamillage Sandeeshwara Kasturiratna, Andree Hartanto

Research Collection School of Social Sciences

Artificial intelligence (AI) systems are increasingly integrated into daily life, not only as tools but also as social partners that people may turn to for interaction and support. This raises important questions about whether, how, and why individuals form attachment-like bonds with AI, and the psychological implications of such attachments. Across five studies involving 1259 unique participants from Singapore and the U.S., the current work developed and validated the 15-item AI Attachment Scale and investigated the dispositional and motivational factors associated with attachment to AI, as well as its emotional and social outcomes. The AI Attachment Scale displayed strong psychometric …

Ongoing Recovery Measurements In Kwinana Shelf Seagrass Meadow In Cockburn Sound 2.5 Years Post Impact Phase To Give Greater Confidence In Recovery Data And For Eia Monitoring, Nicole Said, Chanelle Webster, Simone Strydom, Kathryn Mcmahon

Research outputs 2022 to 2026

Executive summary: Understanding the nature of interactions between multiple stressors is essential for assessing their cumulative impacts on seagrasses and for guiding effective management. Current dredging thresholds are based largely on single stressors (light reduction or sediment burial), despite pressures typically co-occurring, and these thresholds may therefore need refinement to account for interactive effects. In addition, recovery times under single and multiple pressures remain a major knowledge gap, further reducing our ability to accurately predict impacts and implement effective management. This need is particularly pressing in regions facing ongoing dredging pressure. Cockburn Sound, which has already lost ~75% of its …

Periodizing Exercise Medicine Prescription For Patients With Cancer: A Narrative Opinion, Francesco Bettariga, Robert U. Newton, Chris Bishop, Luca Maestroni, Anita Borsati, Alice Avancini, Sara Pilotto, Dennis R. Taaffe, Daniel A. Galvão, G. Gregory Haff

Research outputs 2022 to 2026

Exercise has emerged as an effective therapeutic strategy in cancer management. Long-term supervised exercise programs, including resistance training and aerobic training, can improve body composition and physical fitness, modulate circulating factors (e.g., hormones, cytokines), enhance treatment tolerance, and reduce side effects, potentially influencing cancer progression and reducing mortality risk. Despite advancements in exercise oncology, opportunities remain to refine exercise prescription through the integration of advanced methodologies such as periodization and autoregulatory programming strategies. Periodization, a systematic approach to organizing training over time, has demonstrated benefits in general fitness and clinical populations but is underexplored in cancer care. Emerging evidence suggests …

Interhemispheric Inhibition Modifies Reaction Time Of The Index Finger, Liam C. Tapsell, Christopher Latella, Anthony J. Blazevich, Janet L. Taylor

Research outputs 2022 to 2026

Interhemispheric inhibition (IHI) acts between hemispheres to decrease motor cortical excitability. IHI changes during movement preparation, but it is unknown whether altering IHI, independent of other factors, alters movement initiation. For the index finger abductor muscle (first dorsal interosseous; FDI), IHI is weaker during contralateral index abduction than adduction. Thus, this study aimed to modulate IHI through contralateral contraction and measure resultant changes in reaction time. Fifteen healthy participants (age 19–39 years) completed a reaction-time task requiring brief left index finger abduction. Prior to reactions, participants started either a sustained isometric abduction or adduction contraction of the right index finger. …

Biochar As Additive And Modifier In Bitumen And Asphalt Mixtures, Chathurika Dassanayake, Nuha S. Mashaan

Research outputs 2022 to 2026

Incorporating biochar into pavement materials is a novel and environmentally sustainable approach that aligns with global sustainability goals and advances greener pavement technologies. Studies have shown that biochar significantly enhances the strength, durability, and stability of pavements, while also contributing to sustainability by lowering the carbon footprint associated with traditional construction materials. Additionally, the incorporation of biochar contributes to the sustainability of asphalt engineering by reducing reliance on petroleum-based products and promoting the valorization of biomass. The primary objective of this review is to critically evaluate and synthesize existing research on the use of biochar in bitumen and asphalt mixtures, …

Defeating Evasive Malware With Peekaboo: Extracting Authentic Malware Behavior With Dynamic Binary Instrumentation, Matthew Gaber, Mohiuddin Ahmed, Helge Janicke

Research outputs 2022 to 2026

The accuracy of Artificial Intelligence (AI) in malware detection is dependent on the features it is trained with, where the quality and authenticity of these features is dependent on the dataset and the analysis tool. Evasive malware, that alters its behavior in analysis environments, is challenging to extract authentic features from where widely used static and dynamic analysis tools have several limitations. However, Dynamic Binary Instrumentation (DBI) allows deep and precise control of the malware sample, thereby facilitating the extraction of authentic behavior from evasive malware. Considering the limitations of malware analysis for use with AI, this research had two …

Echoes Of The Modern Training Periodization Concepts In Russia Before The October 1917 Revolution, Sandro Bartolomei, Gulnara Mammadova, Renato Manno, Gregory G. Haff, Jay R. Hoffman, Franco Merni

Research outputs 2022 to 2026

Abstract – Bartolomei, S, Mammadova, G, Manno, R, Haff, GG, Hoffman, JR, and Merni, F. Echoes of the modern training periodization concepts in Russia before the October 1917 revolution. J Strength Cond Res 39(12): 1327–1330, 2025—The debate on the origins of the discipline of training periodization is still ongoing. The text “Olympic Sport, ” published by B. A. Kotov in 1916, was one of the first known books to focus on training methods and strategies for performance development. The book is also considered the first to deal with training organization and periodization. In addition, Kotov was the only author to …

Non-Pharmacological Supportive Care Interventions During Immunotherapy For People With Cancer: A Systematic Scoping Review And Future Directions, Morgan J. Farley, Brighid R. Scanlon, Megan Crichton, Ashley M. Bigaran, Amy C.M. Barnes, Nicolas H. Hart, Patsy M. Yates, Melissa L. Eastgate, Kim Alexander

Research outputs 2022 to 2026

Purpose: Immunotherapy has transformed cancer treatment and outcomes. Patients receiving immunotherapy often encounter immune-related and treatment-related adverse events, leading to substantial supportive care needs. Currently, no recommendations exist to guide the use of non-pharmacological supportive care interventions for people with cancer undergoing immunotherapy treatments. This review aims to summarise the available evidence regarding non-pharmacological supportive care strategies to inform future clinical management and research directions.

Methods: Six electronic databases (PubMed, CINAHL, EMBASE, PsycInfo, Web of Science and Scopus) were systematically searched for studies on non-pharmacological supportive care interventions for adults undergoing immunotherapy, published from October 2014 to October 2024.

Results: …

The Effects Of Acute And Chronic Exercise On Lipocalin-2 In Middle-Aged And Older Adults: A Randomized Control Trial, Carlie Bauer, Marc Sim, Cassandra Smith, Rhiannon Healy, Andrew Garnham, Navabeh Zare-Kookandeh, Elizabeth Byrnes, Mary N. Woessner, Joshua R. Lewis, Itamar Levinger

Research outputs 2022 to 2026

Objective Chronically elevated circulating lipocalin-2 (LCN2) levels are implicated in poor energy regulation, increased cardio-metabolic disease risk, and poor physical function. Exercise is known to improve these factors, but whether LCN2 is modifiable by exercise is not clear. We examined the effect of acute and chronic exercise on LCN2 levels and whether this relates to glucose regulation, body composition, and physical function. Design and methods Thirty-three middle-aged and older adults (45–84 years, median body mass index 26.21 kg/m²) completed an acute high-intensity interval exercise session (HIIE). Participants were randomized to 4 weeks of high-intensity interval training (HIIT) or …

The Importance Of Aged Care Policies In Assisting Older Adults Transition From Home To Permanent Residential Aged Care: A Focused Ethnographic Study, Stacey M. Scott, Annette J. Raynor, Julie S. Dare, Jennifer M. Grieve, Leesa N. Costello

Research outputs 2022 to 2026

Background: The Royal Commission into Aged Care Quality and Safety (RCAC) recommended a redesign of the Australian aged care system to ensure high quality care, respect, and dignity for residents. Responding to the RCAC recommendations, the Aged Care Quality Standards have been strengthened and continue to guide the delivery of safe, high quality care in Australia. This study investigated the experiences of new residents transitioning into an Australian residential care-facility, concentrating on how their experiences aligned with the core principles of the Aged Care Quality Standards. Methods: A focused ethnographic approach was used to address the aim of this study. …

Up From The Archive: On Stigma, Resilience And Chosen Families. Hassan Khalil Thinks With Bernard Gardiner 2018, Hassan Khalil

Research outputs 2022 to 2026

This paper reflects upon Bernard Gardiner's qualitative study of the lived experiences of older gay people living with human immunodeficiency virus (PLHIV) in regional Queensland. The study explores how advancements in the biomedical field have extended the life expectancy of PLHIV, allowing this group to navigate through persistent challenges both psychosocial and structural. Central to Gardiner's study is the exploration of stigma, trauma and financial challenges. The core strength of the study is its participant-led narrative which offered valuable insight into complex lived experiences of ageing PLHIV. Gardiner's findings remain relevant in the contemporary and current context, highlighting the need …

What Is Known About Asthma Care And Management For Children And Young People Under 18 Years Of Age In New Zealand. A Scoping Review, J. Blamires, M. Foster, B. Kanengoni-Nyatara

Research outputs 2022 to 2026

Introduction: Asthma is the most common chronic health condition affecting children in Aotearoa New Zealand, with Māori and Pacific children disproportionately burdened by high morbidity and inequitable care. Despite clinical guidelines and growing research, inconsistencies in diagnosis, treatment adherence, and education persist. This scoping review identifies and maps literature on care models, service delivery, education and support strategies, and experiences of children, young people, and their family/whānau in asthma care and management for those under 18 in Aotearoa New Zealand. Methods: This scoping review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses Extension for Scoping …