Digital Commons Network^™

Facts And Hopes Of Chimeric Antigen Receptor-Redirected Nk T Cells, Amy N Courtney, Xin Zhou, Gengwen Tian, Ying Wang, Leonid S Metelitsa, Gianpietro Dotti

Faculty, Staff and Students Publications

Chimeric antigen receptor (CAR)-engineered invariant NK T cells (CAR-NKT) are a novel cell platform for cancer immunotherapy. Unlike conventional T cells, NKTs are characterized by innate antitumor properties, minimal alloreactivity, and a unique ability to modulate the tumor microenvironment. This article provides a comprehensive overview of preclinical and early clinical studies evaluating CAR-NKTs in both autologous and allogeneic clinical settings. We discuss the contributions of CAR signaling domains, cytokine coexpression, and other functional measures that correlate with CAR-NKT persistence, function, and metabolic fitness. We also discuss the critical role of immunocompetent animal models in elucidating the interactions of CAR-NKTs with …

Analysis Of Leakage In Nearshore Pipelines Using Fitness For Service Method To Ensure Mechanical Integrity Based On Api-579 Level 3, Elriandri Elriandri, Dedi Priadi

Journal of Materials Exploration and Findings

The Fitness for Service (FFS) analysis is performed as a quantitative assessment to evaluate the integrity condition of a pipeline. Essentially, FFS assessment helps determine whether equipment components can operate safely despite existing deficiencies. This evaluation is carried out using the Finite Element Method (FEM). In the case of an underwater pipeline that experiences leak due to anchor pull at the flange connection, it undergoes plastic deformation and is lifted approximately 1 meter. As a mitigation step, inspection and repairs have been carried out by the company. Subsequently, modeling is performed to reconstruct the deformation process of the pipeline. Then, …

An Analysis Of Student Performance In Elementary Linear Algebra At Brigham Young University, Adrienne Irene Christensen

Theses and Dissertations

This study investigates different factors that influence performance in the Elementary Linear Algebra (ELA) course taught at Brigham Young University. These factors include student characteristics such as true freshman status and college enrollment, and content-specific factors such as how performance on essential topics affects overall performance in the course. To analyze the various research questions posed in the study, I used robust linear mixed effects models with random effects controlling for the hierarchical structure of the data. The statistically significant results from these models indicate that (i) true freshmen perform better than other students on exams and in the ELA …

Achieving More Accurate And Interpretable Fraud Detection With Double Machine Learning, Jeremy Andrew Berry

Theses and Dissertations

Fraud detection remains a critical challenge across industries such as insurance, healthcare, finance, and government. Global losses from fraud and financial crime are estimated in the trillions annually, including billions in healthcare and insurance fraud alone. While effective for prediction, traditional machine learning methods often lack causal interpretability and struggle to adapt to evolving fraud tactics. This dissertation investigates the application of Double Machine Learning (DML), an emerging causal inference technique, to enhance both the accuracy and interpretability of fraud analytics. The research compares DML against established causal inference approaches, leveraging a meta-learning framework to evaluate model performance on accuracy, …

Opening Brief For Plaintiff-Appellant Emery Barron, Steven Mitchell, Carolyn Sacco, Shaina Sikka, Madeline H. Meth

Faculty Scholarship

By the time Emery Barron sued Pennsylvania Department of Corrections officials in 2021, they had kept him caged for almost six years in solitary confinement without providing a pathway for him to reenter general population. Department of Correction policy calls for officials to review the ongoing need for solitary confinement after an initial ninety-day stint in disciplinary confinement. However, procedural carve outs allow officials to leave people like Barron in solitary indefinitely without an opportunity to be heard by a decisionmaker and without requiring officials to assert any legitimate penological interest behind the confinement.

Under this scheme, which violated both …

The Lived Experiences Of African American Child Sexual Abuse Survivors And Their Relationships With The Perpetrators, Anita Joyner

Walden Dissertations and Doctoral Studies

Child sexual abuse (CSA) can be detrimental to survivors well into adulthood and can affect the relationships of everyone with whom they are involved. Knowing the perpetrator is a determining factor in the equation and is associated with increased odds of behavioral health challenges among survivors. This is especially true within African American communities, where cultural violence results in an increased level of trauma. The purpose of this qualitative study was to examine the lived experiences of African American CSA survivors and their relationships with the perpetrators. As part of the phenomenological design, data were collected through semi-structured interviews with …

Early Depression Screening In Adults With Opioid Use Disorder, Ekaterina Versace

Walden Dissertations and Doctoral Studies

Abstract This Doctor of Nursing Practice project involved the development and quality appraisal of a clinical practice guideline (CPG) for early depression screening in adults with opioid use disorder (OUD), addressing the absence of standardized, evidence-based screening protocols in addiction treatment settings. Guided by the practice-focused question of whether existing evidence supports the development and evaluation of such a guideline using the Appraisal of Guidelines for Research and Evaluation II (AGREE II) instrument, a systematic synthesis of 35 research articles was conducted, with 15 high-level studies informing guideline development. A multidisciplinary panel of four experts evaluated the CPG using the …

Working Paper No. 104, An Gorta Mór: The ‘Great Hunger’ And Irish Immigrant Labor In 19th Century America, Amanda Bergeson

Working Papers in Economics

This inquiry seeks to establish that portions of the population of Ireland -- responding to what has been referred to in their Celtic language as An Gorta Mór, or in the English language as the ‘Great Hunger -- took to emigrating en masse and therewith contributed bigly to the expansion of America’s labor supply. Bolsterd by Irish immigrants, this expanding mid-nineteenth century labor force provided for an abundance of workers needed for a broadly based industrialization, that would also lead to large-scale urbanization as well as a host of changes in this nation’s social fabric. Of note is that …

Working Paper No. 105, John Locke And The American Experiment, Riley Sharps

Working Papers in Economics

This inquiry seeks to establish that ideas advanced by the Englishman John Locke, regarding private property, natural rights, as well as a social contract for relations between authorities and governed, influenced the American experiment at its founding. Locke’s novel understanding regarding private property greatly influenced leaders railing against British dominance. His ideas were picked up by founding figures such as John Adams, Thomas Jefferson, as well as James Madison, and Thomas Paine. Through their leadership, in particular, Locke’s ideas were carried forward and served as the inspiration behind key concepts appearing in this new nation’s founding documents. First appearing in …

Race, Fear Of Falls, Built Environment And Physical Activity In Older Adults With Cancer, Kristen Fessele

General Submissions: Community and Population-based Materials

Motivation for older adults with cancer (OAC) to engage in physical activity (PA) during and after cancer treatment may be limited by many factors. OAC may be affected by persistent symptoms limiting PA capability such as fatigue, pain and dyspnea, or lack safe home or neighborhood spaces to engage in activity. Fear of falling (FOF) is a major concern among OAC and may decrease PA and life-space mobility. To understand how OAC perceptions of cancer treatment, FOF and their local built environment (BE) influence PA behaviors, we partnered with ResearchMatch.org to recruit a sample of 19 people with a history …

Holistic Support And Development: Collaboration Between Residence Life And Faculty On Short-Term Education Abroad Programs, Kendra Sherman

Seton Hall University Dissertations and Theses (ETDs)

Short-term education abroad programs are designed to increase students’ intercultural competencies, expose them to new cultures and languages, prepare them for future employability, and further their academic development (Castiello-Gutiérrez & Gozik, 2022; Yao, 2021). While education abroad programs may result in strong benefits for students, they are not without their challenges when it comes to facilitating and managing them. Both the faculty who lead these programs and the students who participate in them face challenges respective to their experiences abroad. Many researchers emphasize collaboration between student affairs and academic affairs to alleviate these challenges, but no one office is identified …

The Implementation Of Tact And Bidirectional Intraverbal Training In Teaching A Foreign Language: A Systematic Replication, Karen Parra Caballero

Seton Hall University Dissertations and Theses (ETDs)

The current study replicates and extends Yamaguchi and Matsuda (2024) to evaluate the effects of foreign tact and bidirectional intraverbal training on teaching foreign-language vocabulary to adults. An adapted alternating-treatments design was used to evaluate the effects of learning vocabulary of a foreign language through tact teaching (tacting a picture in French), foreign-native intraverbal teaching (vocalizing a French word in the presence of the Spanish word), and native-foreign intraverbal teaching (vocalizing a French word in the presence of the Spanish word). Each teaching condition had an assigned stimulus set for teaching, and an additional stimulus set was included as a …

Intouch Week Of December 15, 2025, New York Medical College

InTouch

• Record Numbers, Remarkable Research Define 30th Medical Student Research Forum
• Wellness Ambassador Program Welcomes New Student Leaders
• New Test Could Revolutionize Lyme Disease Diagnosis
• Meal Plan Launches Through Vemos Pay
• Off Campus, On Craft: Jeanne Chamas Keeps the Department on Track and the Community in Step

Turning Language Into Insight: How Ai And Forensic Linguistic Analysis Are Transforming Investigations, Alan Saquella

Publications

Language is the fabric of human thought and communication, subtle, layered, and deeply revealing. When scrutinized, it can offer far more than simple testimony; it can hold the keys to motive, identity, intent, contradiction, and context. Traditionally, law enforcement has focused on fingerprints, DNA, surveillance, and physical evidence to solve crimes. Yet one of the most untapped wells of intelligence lies between the lines of written statements from suspects, witnesses, and victims. Now, with the advent of advanced artificial intelligence (AI) and the sophisticated science of forensic linguistics, investigators have powerful new tools to mine language for insights that were …

Oxytocin Varies Across The Life Course In A Sex-Specific Way In A Human Subsistence Population, Abigail E. Colby, Dominik C. Jud, Valerie Baettig, Jordan S. Martin, Camila Scaff, Michael D. Gurven, Benjamin C. Trumble, Bret A. Beheim, Paul L. Hooper, Daniel K. Cummings, Hillard Kaplan, Jonathan Stieglitz, Arnulfo Cary Ista, Adrian V. Jaeggi

ESI Publications

Oxytocin, a hormone linked to reproduction and health, may mediate life-history trade-offs across the human life course. Yet, how oxytocin naturally varies with age remains poorly understood. Here, working with the Tsimane, forager-horticulturalists of lowland Bolivia, we collected the largest sample of oxytocin measurements to date (n = 1,242 samples, n = 405 individuals, age = 2 to 84 y, 51% female), and i) examined how oxytocin varies throughout the life course in females and males, and ii) investigated potential drivers of age- and sex-specific variation. Our sample provides rare insight into the relationship between oxytocin and age in a …

Measuring And Modeling Nonlinear Vibrations In Structures With Mechanical Joints, Suzanna Gilbert

Theses and Dissertations

Many assembled structures have bolted or riveted joints. Aside from providing a convenient method of assembly, mechanical joints have an important effect on the structure's dynamic response to its environment. Friction and microslip within the joints help to damp out unwanted vibration. However, the joints also introduce nonlinearity into the response. Most notably, the natural vibrational modes of the structure no longer have constant natural frequencies and damping ratios. Rather, they shift as a function of vibration amplitude. Several methods exist to characterize the dynamics of nonlinear systems, yet they are generally validated on simple benchmark structures, and many still …

Beyond Barriers: Improving Employment Outcomes For Young Adults On The Autism Spectrum, Kendra L. Cope

UNLV Theses, Dissertations, Professional Papers, and Capstones

Young adults with autism spectrum disorder (ASD) continue to face persistent barriers to employment, often stemming from challenges in communication, adaptability, and multitasking. Virtual reality (VR) has emerged as a promising tool to strengthen these employment skills through immersive, low-stress practice. This study evaluated a VR-based intervention using Floreo VR modules, guided practice, and performance feedback to enhance job readiness among high school students with ASD. A multiple-probe design across three skill domains: multitasking, handling interruptions and changes, and workplace communication to examine skill acquisition and maintenance with three students with ASD aged 16–18. Data from task-analysis checklists, interobserver agreement …

Quantifying Biocrust Evaporation In Arid Lands By Combining Thermal Imaging And Lysimeter Measurements, Rebekah C. Magness

UNLV Theses, Dissertations, Professional Papers, and Capstones

Biological soil crusts (biocrusts) are miniature ecosystems of living organisms incorporated within the soil matrix and established in the topmost millimeters of the soil surface. Biocrust plays a critical role in the hydrologic processes in arid lands, yet the extent to which it increases or decreases evaporation remains unclear. To gain a better understanding of the impact of biocrust on evaporation compared to bare soil, I studied a cyanobacteria-dominated biocrust patch surrounded by bare soil atop a lysimeter in the Mojave Desert near Las Vegas, Nevada. Using high-resolution thermal imaging, and the known latent heat flux from the lysimeter, I …

Examining The Complementary Nature Of Working Memory And Dual Coding Theory, Elizabeth Hofschulte Collins

UNLV Theses, Dissertations, Professional Papers, and Capstones

The working memory system is responsible for maintaining, manipulating, and transferring information into long-term memory, yet it operates under strict capacity limitations. Dual coding theory proposes that information can be encoded both verbally and visually, allowing learners to distribute cognitive load across complementary representational systems. Leveraging dual coding may therefore enhance recall, particularly for noun-based stimuli, though there is little to no research exploring this possibility. In the present study, 529 adults completed a forward digit span task and pre-test and post-test free recall tasks involving concrete, abstract, and mixed nouns. Participants were assigned to one of four instruction groups …

Acute And Chronic Effects Of Neuroinflammation On Hippocampus And Anterior Cingulate Cortex Network Dynamics, Lauren A. Crew

UNLV Theses, Dissertations, Professional Papers, and Capstones

Neuroinflammation has emerged as a critical modulator of cognitive function and neural circuit dynamics, yet the distinct contributions of acute and chronic neuroinflammation to brain function remain poorly defined. This dissertation examines how inflammation independently alters large-scale neural activity and behavior, focusing on interactions between the hippocampus (HPC) and anterior cingulate cortex (ACC), regions essential for memory and executive processes. Using in vivo electrophysiological techniques in a rodent model, this study compares the effects of short-term (acute) and prolonged (chronic) neuroinflammatory states, induced via Poly I:C, on neural oscillations, regional coherence, and spatial coding. Findings reveal that even transient inflammation …

Automated Spectrum Analysis And Radionuclide Identification For Robot-Based Gamma Probes, Kennedy Ochieng Mengoh Alila

UNLV Theses, Dissertations, Professional Papers, and Capstones

Gamma spectroscopy is a technique used for the detection and identification of nuclear materials. Gamma-ray emission by radio nuclides is detected using scintillation detectors or semiconductor detectors such as NaI and CZT. Robot-based gamma probes enable radiation measurements in large areas and hard-to-reach cluttered hazardous environments, which significantly reduces radiation risks to personnel. The robotic probes require automated on-board gamma spectrum analysis and capabilities with platforms (unmanned aerial vehicles and unmanned ground vehicle systems) which use Robot Operating System (ROS). The aim of this thesis was to develop a method of an automated spectral analysis and isotope identification for robot-based …

Ultrafast Dynamics Of Two-Dimensional Electron Systems, Randy Michael Sterbentz

UNLV Theses, Dissertations, Professional Papers, and Capstones

On-chip terahertz time-domain spectroscopy (THz-TDS) is a technique useful for measuring the ultrafast electrodynamics of two-dimensional (2D) electronic systems. Charge carrier collisions occur on the sub-picosecond time scale, and strongly correlated electron interactions (such as superconductivity) typically have energies on the order of milli-electron-volts. These phenomena fall within the terahertz bandwidth, which has historically been difficult to access. Commercial electronics operate with transistors capable of switching rates of around 100 GHz, while small band gap semiconductors (like InGaAs) can detect light down to 0.75 eV (180 THz). When combined with the difficulty of measuring 2D layered materials, with lateral sizes …

A Phenomenological Study Of The Experiences Of Adolescents With Emotional Behavioral Disorders In High School, Melissa Lawson

UNLV Theses, Dissertations, Professional Papers, and Capstones

Adolescents with emotional and behavioral disorders (EBD) face significant challenges in forming and maintaining peer relationships, yet their voices and lived experiences remain largely absent from the research literature. This phenomenological study explored how high school students with EBD perceive the impact of peer relationships on their academic, social, and emotional experiences at school. Using Moustakas's (1994) modification of the StevickColaizzi-Keen method, the researcher conducted in-depth semi-structured interviews with seven high school students (ages 15-18) who had received special education services under the EBD eligibility category for 5 to 10 years in a large, urban southwestern school district.

Five universal …

Perceptions And Behaviors Of Female Title I Principals And Faculty Trust In The Post-Covid-19 Educational Environment, Jessica A. Robbins

UNLV Theses, Dissertations, Professional Papers, and Capstones

Faculty trust in principals is essential to a healthy school culture, yet it remains one of the most fragile and complex aspects of leadership, particularly in Title I schools (Tschannen-Moran, 2007, 2014; Tschannen-Moran et al., 2015). While trust has been widely studied, fewer investigations have focused on the specific behaviors female principals use to build trust in the post-COVID era (Berkovich, 2018; Bukko et al., 2021; Handford & Leithwood, 2013; Jeanquart-Barone, 2013; Zajda et al., 2023; Zheng et al., 2021). Research suggests that women in leadership must be deliberate in fostering trust, yet their behaviors are often judged more harshly …

Face Recognition Ability: The Role Of Facial Experience Across The Lifespan, Kirsty Kulhanek

UNLV Theses, Dissertations, Professional Papers, and Capstones

The other-race effect is a phenomenon in which individuals are better able to recognize individuals of their own race than individuals of another race. These effects begin to develop during the first year of life and may be attenuated by intergroup contact. Limited research in the language domain has suggested that multilingualism may result in easier learning of non-native speech contrasts, so it is of interest whether early experience with racially diverse faces may result in more easily learning to recognize unfamiliar race faces. We conducted two studies to examine the effects of early diverse experience with faces on recognition …

Integrating Classical Singing Techniques To Aid Natives In Performing Traditional Tongan Folk Songs Of The Late Queen Sālote Tupou Iii, Pauline 'Ofa Vaitāfā Tamale

UNLV Theses, Dissertations, Professional Papers, and Capstones

This document introduces a structured, classical vocal approach to equip native singers with healthier performance techniques and enable anyone in the music world to perform the art songs derived from the poetry and compositions of Queen Sālote Tupou III. The objective of this project is to provide performers, particularly those with a native proficiency, with classical techniques to perform this music with vigor while circumventing vocal fatigue caused by the linguistic, dialectal, and cultural demands inherent in the repertoire. Queen Sālote Tupou III (1900–1965) reigned for nearly 50 years – the longest of any Tongan monarch – and left an …

Assessing The Relationship Between Treatment Quality, Matching And Dosage And Juvenile Justice Outcomes Among Youth With Co-Occurring Substance Abuse And Mental Health Disorders, Kevin T. Wolff, Michael T. Baglivio, Joshua A. Lang

Publications and Research

This study examined differences among youth in deep-end juvenile justice residential placement who did, and did not, present with co-occurring disorders. The prevalence of cooccurring mental health and substance use/abuse issues was found to be 19%, far lower than that of prior work. Researchers demonstrated more similarities than differences between youth with and without co-occurring disorders, both in terms of their criminal histories and the prevalence of their criminogenic needs. Additionally, the residential programs across Florida appear to provide treatment at similarly high levels of integrity, as measured by 1) matching treatment services to the highest three dynamic risk assessed …

Objective Vs. Perceived Maternal Smartphone Use And Observed Mother-Infant Interaction Quality, Alison K. Ventura, Lara N. Wolfers, Sarah M. Coyne, Rachel Pfafman, Sabrina Uva, Karla I. Ceja Almontes, Aniruddha S. Shinde, Adam M. Galovan, Brandon Mcdaniel

Health Services and Informatics Research

Introduction:

Prior research links maternal smartphone use to reduced sensitivity and responsiveness to infant cues, but emerging evidence suggests that mothers' perceptions of their smartphone use - such as feelings of empowerment or distress - may also shape the quality of mother-infant interactions. This study examined how both objective and perceived smartphone use related to mother-infant interaction quality in naturalistic settings.

Method:

Participants were 147 mother-infant dyads from a longitudinal study of smartphone use and infant development. When infants were 2 months old, mothers completed 5 days of ecological momentary assessment (EMA), reporting time spent with their infant, perceived smartphone-related …

The Evolution Of Southern Ocean Net Primary Production In A Changing Climate: Challenges And Opportunities, Alessandro Tagliabue, Thomas Ryan-Keogh, Alex Baker, Thomas S. Bibby, Chris Follett, Maeve C. Lohan, Alberto Naveira-Garabato, Daniel J. Mayor, Angela Milne, C. Mark Moore, Simon Ussher

School of Geography, Earth and Environmental Sciences

Net primary production in the Southern Ocean plays a critical role in governing ecosystem production, the biological carbon pump, and global biogeochemical cycles. Recent work has advanced our understanding of novel factors regulating Southern Ocean net primary production and the regional physiological adaptations employed by Southern Ocean phytoplankton in terms of their photosynthetic strategies and resource acquisition. Here we assess trends in Southern Ocean net primary production from different remote sensing algorithms and bgc-Argo floats to compare them to the latest Earth System Models used to forecast future changes under three different future climate scenarios. Overall, remote sensing and bgc-Argo …

Meta-Analysis Of The Spatial Distribution And Composition Of Plastic Macro-Debris In Indonesia, Max R. Kelly, Muhammad Reza Cordova, Susan Jobling, Richard C. Thompson

School of Biological and Marine Sciences

Plastic pollution is recognised as a global environmental problem with Indonesia identified as a major contributing source. However, a comprehensive understanding of pollution patterns remains hindered by fragmented data and methodological inconsistencies across studies. This study synthesises data from 44 peer-reviewed publications, spanning 68 field locations and 328 individual study sites across 19 provinces, to map the spatial distribution and composition of plastic macro-debris in Indonesia. We identified plastic bags, plastic food packaging, and plastic bottles as the three most prevalent item types, occurring as top three ranked items in 65 %, 63 %, and 40 % of field locations, …