Digital Commons Network^™

Response To Replication Stress And Maintenance Of Genome Stability By Wrn, The Werner Syndrome Protein, David K. Orren, Amrita Machwe

Markey Cancer Center Faculty Publications

Werner syndrome (WS) is an autosomal recessive disease caused by loss of function of WRN. WS is a segmental progeroid disease and shows early onset or increased frequency of many characteristics of normal aging. WRN possesses helicase, annealing, strand exchange, and exonuclease activities and acts on a variety of DNA substrates, even complex replication and re- combination intermediates. Here, we review the genetics, biochemistry, and probably physiological functions of the WRN protein. Although its precise role is unclear, evidence suggests WRN plays a role in pathways that respond to replication stress and maintain genome stability particularly in telomeric regions.

Reading Colonial Transitions: Archival Evidence And The Archaeology Of Indigenous Action In Nineteenth-Century California, Lee M. Panich, Gustavo Flores, Michael Wilcox, Monica V. Arellano

Faculty Publications

Archaeologists in North America and elsewhere are increasingly examining long-term Indigenous presence across multiple colonial systems, despite lingering conceptual and methodological challenges. We examine this issue in California, where archaeologists and others have traditionally overlooked Native persistence in the years between the official closing of the region's Franciscan missions in the 1830s and the onset of US settler colonialism in the late 1840s. In particular, we advocate for the judicious use of the documentary record to ask new questions of Indigenous life during this short but critical period, when many Native Californians were freed from the missions and sought new …

Master Of Social Work Portfolio, Courtney Marie Aadland-Lewis

Graduate Student Portfolios, Professional Papers, and Capstone Projects

No abstract provided.

Assessing Soil Properties For Optimized Irrigation Development In Sudan, Northern Africa, Suhib Hamid, Derek M. Heeren, Aaron R. Mittelstet, Saleh Taghvaeian, Randall S. Ritzema

Department of Agricultural and Biological Systems Engineering: Presentations and White Papers

Sustainable irrigation methods maximize agricultural productivity in Northern African countries like Sudan. This project evaluates soil properties to develop optimized irrigation strategies for Sudan's arid and semi-arid climate. Assessing soil characteristics such as texture, infiltration rates, and nutrient content informs the selection of modern irrigation systems. Data from 3,192 locations, collected using GPS and ring infiltrometers for infiltration rates, alongside laboratory analyses for soil properties, were employed. A ranking system determined suitable irrigation systems for specific soil classes, considering factors like slope, wind, crop tolerance, available water capacity (AWC), drainage, germination, capital cost, labor cost, maintenance, and evapotranspiration (ET). The …

A Cross-Sectional Analysis Of Preterm Birth Incidence And Survival In Al Kharj, Saudi Arabia, Mshari Alghadier, Muneera Alasraj, Ragab Elnaggar, Mashael Alazmi, Asma Aldawsari, Saud Alnadah, Faisal Alqahtani, Donia Zaghamir

Saudi Medical Journal

Objectives: To understand the prevalence and survival rates of preterm birth (PTB) is of utmost importance in informing healthcare planning, improving neonatal care, enhancing maternal and infant health, monitoring long-term outcomes, and guiding policy and advocacy efforts. Methods: The medical records of preterm infants admitted to the Neonatal Intensive Care Unit (NICU) with a diagnosis of prematurity at the Maternity and Children’s Hospital (MCH), Al Kharj, Saudi Arabia, were reviewed between January 2018 and December 2022. Data were collected on birth weight (BW), gender, number of live births, gestational age, mortality, nationality, APGAR score, length of stay in the NICU, …

Decision Making For People Living With Hiv/Aids Using The Theory Of Innovation Diffusion Model At The Western Provident Association Turen Foundation, Tri N. Sasono, Esti Yunitasari, Ninuk D. Kurniawati, Nusalam Nursalam, Ainun Hurrotaini, Makhfudli Makhfudli, Ferry Efendi

Saudi Medical Journal

Objectives: To describe how people living with HIV/AIDS (PLWHA) make decisions using the diffusion of innovation theory model. Decisions occur when individual decision makers engage in activities that guide choices to adopt or reject a particular innovation. Methods: This is a descriptive analysis research using a survey method. Data collection was carried out using a decision making questionnaire. The subjects in this research were HIV/AIDS sufferers (PLWHA) who lived in Turen, Indonesia. The number of research subjects was 36 respondents obtained using the purposive sampling technique on January 2023. Results: The research design used the correlation method with a cross …

Borderplex Business Barometer, Volume 8, Number 7, Thomas M. Fullerton Jr., Steven L. Fullerton

Border Region Modeling Project

No abstract provided.

Incorporating Intrinsic Structures Into Entity Matching And Representation Learning, Ween Jiann Lee

Dissertations and Theses Collection (Open Access)

The proliferation of internet-connected devices and online services has generated vast amounts of user-generated content in various formats, such as text, visual, and spatial information. Despite the potential of advanced deep learning techniques, challenges such as fragmentation, lack of cohesive structure, and the inability to capture intrinsic data structures persist, affecting data amalgamation and quality. Our research addresses these challenges by enhancing entity matching and representation learning across graph, semi-ordered, and spatial data. These advancements have significant implications for applications in transportation, recommendation systems, and urban planning.

In entity matching, we introduce Robust BiPoly-Matching and Semi-Ordered Bidirectional Poly-Matching. Matching records …

Creating And Delivering Audio Descriptions For Videos, Rosiana Natalie

Dissertations and Theses Collection (Open Access)

Despite anti-discrimination regulations mandating the provision of audio descriptions (ADs), the majority of online video content remains inaccessible to blind and low-vision (BLV) individuals. This is because these ADs are either absent or fail to adequately address the diverse and unique needs of the audience. Traditionally, content creators have relied on professionals to author ADs. However, this gold standard may not be accessible for some content creators because this method is still costly and has a long turnaround time. Moreover, when ADs are available, they tend to be static and unalterable, failing to cater to the unique preferences of BLV …

Essays On Artificial Intelligence (Ai) In Management, Bowen Zhou

Dissertations and Theses Collection (Open Access)

This dissertation comprises three essays that investigate the transformative potential of Artificial Intelligence (AI) in business.

Chapter 1 investigates the fundamental issue of how integrating AI within R&D activities influences a firm’s market value. We developed an "AI Index" using patent data and textual analysis. Interestingly, empirical results indicate a negative correlation between AI integration and market value. However, this does not suggest that AI is an unviable avenue for exploration. Further analysis of the boundary conditions reveals that complementary assets are crucial for successful commercialisation, highlighting that while AI adoption is costly, these assets significantly enhance its market value. …

Examining A Regulatory Flexibility Framework Of Psychological Distress: Integrating Distress Tolerance, Emotion Differentiation, And Emotion Regulation Flexibility, Germaine Yue Qi Tng

Dissertations and Theses Collection (Open Access)

Several theoretical accounts identify emotion regulation (ER) difficulties, including poor abilities to withstand or distinguish negative emotions, as a transdiagnostic risk factor for symptoms of psychological distress. Considering this, nascent evidence hints that ER flexibility may be a mediating mechanism that explains the relationship between specific ER abilities (i.e., distress tolerance, negative emotion differentiation) and distress symptoms. Across time-lagged (Study 1) and three-wave longitudinal (Study 2) investigations of college-aged adults, a regulatory flexibility framework of distress was examined in which ER flexibility mediates the respective pathways from distress tolerance and negative emotion differentiation to psychological distress symptoms. Furthermore, we explored …

Decentralized Consensus And Governance For Collaborative Intelligence, Huiwen Liu

Dissertations and Theses Collection (Open Access)

The data economy today is becoming increasingly collaborative in nature. Take business intelligence, for example. To unleash the full potential of big data, it is essential to integrate multi-source data depicting entities from a multi-faceted and multi-modal perspective, which, not surprisingly, is not achievable by any company alone. In collaborative intelligence, there are two core issues, namely "trust" and "incentive". The core mechanisms to solve these two problems are consensus and tokenization separately.

To solve the trust problem more effectively, we propose a systematic consensus evaluation framework to investigate whether existing consensus algorithms can do so. After a lot of …

Essays On Estimating Firm-Level Production Function With Spatial Dependence, Bo Lin Ng

Dissertations and Theses Collection (Open Access)

This dissertation consists of two chapters on the estimation of firm-level production functions when spatial effects are present. In joint work with Pao-Li Chang, chapter 1 focuses on the impacts of global value chains (GVC) on the firm-level outcomes of Singapore. First, we quantify Singapore’s participation in global value chains (GVC) using the export decomposition framework of Borin and Mancini (2019), before using these indicators to analyse how GVC participation affects sectoral-level valueadded and employment. We find that gross exports and foreign final demand have become more important for Singapore’s value-added, largely driven by the Services sectors. We then use …

Impact Of Organized Activity Participation On Emotional Distress For Adolescents With Disabilities, Adam Langenfeld, Rebekah Hudock, Rebecca J. Dosch Brown, Marla Eisenberg

Journal of Youth Development

Adolescents who have been diagnosed with disabilities constitute a significant portion of the school population in the United States. For example, the National Survey of Children’s Health identified one in four children ages 12 to 17 as having special healthcare needs in 2019 (Data Resource Center for Child and Adolescent Health, n.d.). These adolescents are often diagnosed with a wide range of conditions, ranging from specific learning difficulties to more global delays across developmental domains. In the school setting, adolescents with disabilities often have an individualized educational program (IEP). Mandated by the Individuals with Disabilities Educational Act (IDEA) of 2004, …

Foreign Body Ingestion, Children's Mercy Kansas City

Clinical Pathways

No abstract provided.

Identifying And Removing Barriers To Accessibility In Environmental Education And Outdoor Recreation, Patricia Bonnin

School of Education and Leadership Student Capstone Projects

There are numerous mental, physical, and socio-emotional health benefits to spending time outdoors, and this is especially true for people with disabilities. However, outdoor spaces such as park systems, nature centers, and other natural places are typically not accessible for people with disabilities. Research shows there are numerous barriers they encounter when trying to attend outdoor areas. The capstone project, titled Nature Adapted: Guidebook for evaluating and modifying current programs and practices to increase outdoor accessibility, was created to assist environmental education centers and outdoor recreation organizations in becoming more inclusive. It includes information sections, pre-assessements, reflections, and places to …

Co-Teaching Secondary Dual Eligible Students, Heidi Macomber

School of Education and Leadership Student Capstone Projects

Students who qualify for both English Language services and Special Education services tend to be underserved and have high failure rates in secondary schools. This project investigates the details related to dual eligible students’ underachievement and strives to create a curriculum that appropriately integrates language learning into topics such as identity and mental health. Research relates to methods of assessment that lead to qualification for both English language services and Special Education services. It also evaluates the complicated nature of co-teaching and the many methods for co-teaching that have been developed through research. In addition, this research shows that dual …

Increasing Diversity In Advanced Placement Classrooms Through Culturally Responsive Pedagogy, Megan Volgren

School of Education and Leadership Student Capstone Projects

This thesis has been designed around the question: How can AP literature teachers use culturally relevant pedagogy to make changes to their curriculum to increase diversity in their classes? Most schools offer advanced classes for students, many of which offer opportunities for them to gain college credit while in school. Yet, these opportunities are not equitably distributed. Students of color are often absent from Advanced Placement (AP) classes. This thesis explores the reasons behind this inequality and considers some changes that can be made to promote equality in schools. The focus of the accompanying project is to create a unit …

School-Wide Policies To Support Ell Students With Lgbtqia+ Identities, Camille Verly

School of Education and Leadership Student Capstone Projects

My research question is What school-wide policies can be implemented to support ELL students with LGBTQIA+ identities? LGBTQIA+ high school students face a myriad of challenges in achieving full integration within academic and school culture. These challenges are especially pronounced for students from an English Language Learner (ELL) background, who may also grapple with language barriers and cultural differences. This intersectional group is at higher risk of marginalization, and as such, they are in particular need of holistic support within their educational environment. This project is the development of a comprehensive website designed to serve as a resource for all …

Building Skills For Success: An Esol Job Readiness Curriculum For Adult Ukrainian Refugees, Shannon Daniels

School of Education and Leadership Student Capstone Projects

The growing number of Ukrainian refugees in North America has highlighted the need for English language learning resources focusing on employment content. This capstone project aims to fulfill this requirement by developing an ESOL (English for Speakers of Other Languages) curriculum on practical employment skills and communication. The curriculum considers the importance of cultural identity and the impact of trauma on the learner. It is based on Communicative Language Teaching (CLT) principles and Task-Based Learning (TBL). It is intended to assist refugees in making meaningful contributions to their families and communities through work. The curriculum emphasizes communication strategies relevant to …

Pen Pal Programs As An Effective Tool For Elementary Writing And Intercultural Learning, Michelle Babb

School of Education and Leadership Student Capstone Projects

Research has demonstrated how writing can be a challenge for young students. Motivation, authentic use, and low stakes environments are beneficial methods to build student writing confidence. Pen pal programs are an effective way to provide those benefits to student writing. These programs can also assist in students’ ability to build intercultural connections, which holds important skills in the modern world. However, research on pen pal programs is limited, and teachers often lack the time and resources to begin such a program for their students. The project involved creating a website resource for teachers who are interested in developing pen …

The Integration Of Ipads In Secondary Schools: Improving Students’ Writing Proficiency And Learning Achievement During The Note-Taking Process, Josephine Borchert

School of Education and Leadership Student Capstone Projects

The research question addressed in this study was: To what extent does the integration of iPads in secondary school classrooms impact students’ writing proficiency and learning achievement, especially during the note-taking process? The topics reviewed in the literature include the difficulties students face with writing, how poor writing skills impact overall proficiency as well as learning achievement, and the various methods of note-taking, starting with the pen-and-paper method leading to digital note-taking. The website created for the project focuses on informing teachers about different writing strategies and note-taking methods to help students increase their writing skills during the note-taking process. …

Healing Students’ Collective Trauma And Growing With School Gardens, Will Ashwood

School of Education and Leadership Student Capstone Projects

This paper examines the potential of school garden projects as a therapeutic intervention for addressing collective trauma among students. It investigates how such gardens can help students recognize, work through, and heal from trauma or PTSD, and explores the benefits of using a therapeutic garden as a setting for learning, healing, and personal growth. The significance of this work lies in its demonstration of how building, implementing, and maintaining a school garden can benefit educational institutions, families, and the broader community. It highlights how school gardens can integrate with existing curricula and Positive Behavioral Interventions and Supports (PBIS) to enhance …

Teacher Identity Development Through Critical Self Reflection, Kelly Holmin

School of Education and Leadership Student Capstone Projects

Many educators struggle daily to balance the many facets of their teacher identity, encompassing their personal and professional lives, as well as how they are portrayed in the media and political realm. This along with the other demands of the job can often lead to teacher identity conflict. While teacher identity conflict is a necessary component to growth throughout one's career, lack of support through these challenges can create frustration, stress, and ultimately cause educators to leave the field altogether. This paper explores the research question: How can educators engage in critical self reflection to overcome conflicts in their teacher …

Climate Change Education For Student Agency, Katie Kirschbaum

School of Education and Leadership Student Capstone Projects

While there is no single solution to climate change, climate change education has been identified as a key component. This capstone paper and the unit plan developed for this capstone project seek to answer the research question: How can a biology curriculum that incorporates climate change science, impacts, and solutions foster a global citizenship mindset and pro-environmental behaviors in high school students? The literature review covers dimensions of global citizenship, defines climate change education, identifies what influences pro-environmental behavior, and discusses adolescent development as it relates to pro-environmental behavior. The resulting ten-lesson unit plan is designed for high school teachers …

Putting Play In The Elementary School Classroom, Robert Mchugh

School of Education and Leadership Student Capstone Projects

Elementary school is a major setting for children’s development and the beginning of their academic journey learning language arts, math, and more. One of the primary ways that children learn and develop is through play. This capstone addresses the research question: How can organized play opportunities in elementary schools be leveraged to help nurture students’ development and strengthen their academic learning outcomes? This capstone report delves into the author's personal and professional connections to the topic of children’s play. Through the process of literature review, evidence is compiled to show that play opportunities strengthen the development of children’s physical health, …

Using Zombie Literature To Build Skills In Responding To Real Events For High School Students, Sarah Olson

School of Education and Leadership Student Capstone Projects

This project seeks to enhance student engagement in English language arts through zombie literature, bridging fiction and reality by exploring the question How can zombie literature be used in high school language arts curriculum to discuss and process real-world issues and events? It examines research on fiction's societal impact and horror's ability to boost student interest. The curriculum, adaptable for all high school levels, guides students in connecting fictional narratives to real-life experiences. By exploring the intersection of zombies, literature, and society, the project aims to create a more engaging and relatable learning experience for students.

Best Practices In Screening Kindergarten Students For Multilingual Services, Kathryn Conover

School of Education and Leadership Student Capstone Projects

This research paper aims to answer the question, “what do teachers need to know in order to effectively screen kindergarten students for multilingual services?”. Through a synthesis of relevant research, the paper details the multilingual learner screening process in Minnesota, identifies inefficiencies and validity issues with the process, and suggests revisions to make the process more accurate. Researchers have emphasized the importance of accuracy in screening students, arguing that the overidentification of multilingual students is costly, stealing time and resources from students and teachers. There are many different strategies that can be taken at each step of the kindergarten multilingual …

Stories Elicit Feelings Of Kinship And Inspire Pro-Environmental Behavior, Ellen Shaw

School of Education and Leadership Student Capstone Projects

Humans pass down stories to transmit ways of knowing and ways of interacting within their culture. For Indigenous humans, stories give outsiders insight into a deeply intertwined connection with the environment. As a woman of European descent teaching Environmental Education classes, my lack of awareness inspired the question, How can a story lead to adolescents developing a kinship with the more-than-human elements of a place and lead to pro-environmental behavior grounded in reciprocity? The literature review focused on elevating Indigenous authors such as; Robin Wall Kimmerer, Gregory Cajete, Jessica Hernadez, Albert Wiggan, Masanobu Fukuoka. Traditional Ecological Knowledge is the current …

How Can Urban Nature-Based Preschools Partner With Churches To Support Each Other?, Sarah Sinclair

School of Education and Leadership Student Capstone Projects

Nature-based preschools are increasing exponentially across the United States. These preschools combine best practices in early childhood education with place-based environmental education. Nature is the unifying theme of nature-based preschools, with programs spending a significant amount of time outdoors learning in, with, and about the natural world. Many nature-based early childhood educators are seeking to create urban nature-based preschools to reach children and communities with little access to green spaces or natural habitats. Urban nature-based preschools thus require locations that have attached green space or can access public green space easily. In most states of the U.S., these preschools must …