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Articles 141871 - 141900 of 1823784
Full-Text Articles in Entire DC Network
An Exploration Of Misophonia In The Literature, Megan E. Singer
An Exploration Of Misophonia In The Literature, Megan E. Singer
Honors Projects
Misophonia is a disorder that elicits an extreme negative reaction to specific auditory and visual stimuli. Triggering stimuli, which are often human produced, provoke an array of symptoms including heightened negative emotions along with autonomic nervous system responses. Despite being a relatively common disorder, misophonia is still inadequately recognized and is often classified under conditions such as obsessive-compulsive disorder and anxiety. No cure for misophonia currently exists, but there are many treatments and coping mechanisms used by people with misophonia to ease their symptoms. This comprehensive review synthesizes current research on misophonia, exploring underlying mechanisms, comorbidities, diagnostic methodologies, and treatment …
It’S Heavy: Experiences Of Students From Underrepresented Communities At Grand Valley State University’S Frederik Meijer Honors College, Abigail Palmiter
It’S Heavy: Experiences Of Students From Underrepresented Communities At Grand Valley State University’S Frederik Meijer Honors College, Abigail Palmiter
Honors Projects
The present research uncovers the factors impacting the underrepresentation of minorities within the Frederik Meijer Honors College (FMHC) at Grand Valley State University. Our findings shed light on the systematic barriers’ minority students encounter during their time within the FMHC. Our qualitative data was obtained through a sample of convenience. The findings of this research are as follows: 1.) The location of the honors program building, Niemeyer Learning and Living Center, provides a barrier for students to feel included within the program; 2.) There is a negative stereotype of honors students that can cause stress on honors students; 3.) Students …
The Hidden Monetary State, Gabriel Rauterberg, Joshua Younger
The Hidden Monetary State, Gabriel Rauterberg, Joshua Younger
Faculty Scholarship
Money is a motley. While the state enjoys a monopoly on issuing new physical currency, a variety of instruments serve money-like roles in the financial system. The commercial banking system significantly augments the money supply through issuing deposits. Alongside it, a shadow banking system has also developed, offering a range of deposit substitutes.
This Article seeks to cast new light on the U.S. financial system by exploring how, over the course of the twentieth century, federal policymakers engaged in a series of distinct and largely uncoordinated monetary experiments. As we show through historical case studies, federal authorities designed, promoted, and …
Digital Catharsis Or Harmful Exposure? A Thematic Analysis Of Self-Directed Violence Reddit Posts, Lindsay A. Lundeen, John R. Mccall, Amanda Sams Bradshaw, Erika L. Leblanc, Lizy Humphrey
Digital Catharsis Or Harmful Exposure? A Thematic Analysis Of Self-Directed Violence Reddit Posts, Lindsay A. Lundeen, John R. Mccall, Amanda Sams Bradshaw, Erika L. Leblanc, Lizy Humphrey
Counseling, Leadership, and Research Methods Faculty Publications and Presentations
Many feel uncomfortable discussing self-directed violence with individuals in their social circle, often leading to concerned posts on social media. Previous studies address self-harm, suicide, and nonsuicidal self-injury; however, minimal literature combines suicide and nonsuicidal self-injury to explore common themes representing self-directed violence. This study identified themes from suicide and self-harm subreddit communities, with themes common to each subreddit comprising themes of self-directed violence. Using 1,989 Reddit posts from suicide and self-harm communities, we employed an inductive thematic analysis to explore how users discussed self-directed violence within anonymous online communities. Ultimately, the impact of using Reddit for discussion of self-directed …
First-In-Human Hyperpolarized Mri For Tumor Metabolism In Hnscc, Stephen Y Lai, Vlad C Sandulache, Dawid Schellingerhout, Clifton D Fuller, Yunyun Chen, Christopher M Walker, James A Bankson
First-In-Human Hyperpolarized Mri For Tumor Metabolism In Hnscc, Stephen Y Lai, Vlad C Sandulache, Dawid Schellingerhout, Clifton D Fuller, Yunyun Chen, Christopher M Walker, James A Bankson
Faculty, Staff and Student Publications
This case report describes the use of hyperpolarized magnetic resonance imaging (MRI) in a patient with head and neck squamous cell carcinoma (HNSCC) to demonstrate its translational viability.
The Impact Of Pac-Loaded Polymer Membrane Thickness On Chloroform Removal And Comparison Of Solvent And Thermal Membrane Regeneration Methods, Yizhi Hou, Brooke K. Mayer
The Impact Of Pac-Loaded Polymer Membrane Thickness On Chloroform Removal And Comparison Of Solvent And Thermal Membrane Regeneration Methods, Yizhi Hou, Brooke K. Mayer
Civil and Environmental Engineering Faculty Research and Publications
Powdered activated carbon (PAC) has better adsorption performance than granular activated carbon (GAC) and is widely used in water purification. In most cases, PAC is dosed into water directly, then precipitated as sludge, and landfilled. In this study, PAC was mixed with a polymer and dissolved in dimethylformamide (DMF) solvent to form a PAC-loaded membrane, which was then tested for chloroform removal. The chloroform adsorption capacity of the PAC membrane increased with increasing membrane thickness because of higher carbon loading. However, regardless of membrane thickness, the flux of the PAC membranes was similar since flux resistance predominantly occurred at the …
A Market Mechanism For The Creation Of A Climate-Differentiated Market In The Steel Industry, Laura Garcia Cancino, Perrine Toledano
A Market Mechanism For The Creation Of A Climate-Differentiated Market In The Steel Industry, Laura Garcia Cancino, Perrine Toledano
Columbia Center on Sustainable Investment
The heavy industry sector, a significant contributor to global CO2 emissions, is at a critical juncture. Accounting for 25% of total CO2 emissions annually, this sector is poised to see an increased demand for materials through 2050, particularly from developing countries focused on infrastructure expansion and transitions toward net-zero emissions. However, the sector's dependency on high-emission technologies, notably in steelmaking, underlines the pressing need for a swift and decisive shift to low-emission alternatives.
Our latest publication under the COMET initiative, A Market Mechanism for the Creation of a Climate-differentiated Market in the Steel Industry, introduces a twofold market mechanism specifically …
Climate Impact Screening And Reporting: A Venture Capital Perspective, Ajay S. Jagdish, Perrine Toledano, Ana M. Camelo Vega
Climate Impact Screening And Reporting: A Venture Capital Perspective, Ajay S. Jagdish, Perrine Toledano, Ana M. Camelo Vega
Columbia Center on Sustainable Investment
According to the International Energy Agency’s (IEA) Net-Zero Scenario, about one-third of the emissions reductions needed by 2050 depend on technologies that are currently in development. Additionally, climate adaptation finance faces an even larger investment gap.
The Climate Venture Capital community must demonstrate tangible climate impact to truly earn its reputation.
However, accurately and reliably screening, evaluating, and monitoring climate impact is challenging, with many metrics and methods still needing to be ascertained, clarified, and standardized.
With the support of Princeville Capital, CCSI offers insights into unresolved issues:
- Attribution and baselining
- Paris-aligned thresholds for prioritization
- Indirect impact and tailored KPIs …
Smokejumper Magazine, July 2024, National Smokejumper Association
Smokejumper Magazine, July 2024, National Smokejumper Association
Smokejumper and Static Line Magazines
This issue of the National Smokejumper Association (NSA) Smokejumper Magazine, contains the following articles: Message from the President; A Tribute to a Smokejumper; Down the Yukon Alone; North Cascades Pararescue Operations, 1957-1989; What Happened to America's Middle Class?; How Bobby Montoya Saved My Life; GAC Goats; The Burning of Ruth; Gone But Not Forgotten: South Canyon Fire; Just Keep Them From Burning the Place Down; Remembrances; The Failures of Fire, Law Enforcement, and Other Agencies at the Lahaina, Maui, Fire; Sounding Off; Blazing A New Trail; Reflections on Wildland Firefighting; Odds and Ends; Notes from the Ranks; May 1981 Redding …
Exploring Mean Reversion Dynamics In Financial Markets: Insights From Hurst Exponent Analysis, Shifa Hasan, Renu Ghosh
Exploring Mean Reversion Dynamics In Financial Markets: Insights From Hurst Exponent Analysis, Shifa Hasan, Renu Ghosh
The Indonesian Capital Market Review
The current study investigates mean reversion and the speed of mean reversion within financial mar- kets at BSE 200 and NSE Nifty 200 for a data set of 20 years (2004–2024). It employs a variety of techniques, including traditional tests like the Augmented Dickey-Fuller (ADF) and Philips-Perron (PP) tests, as well as long-term dependency analysis using the Hurst exponent. The Ornstein-Uhlen- beck process facilitated the speed of mean reversion. Empirical data demonstrates that mean rever- sion processes exhibit Hurst exponent values less than 0.5, suggesting mean reverting behaviour. This signifies the importance of adopting long-term perspectives in decision-making and trading …
An Examination Of Educators’ Approaches And Strategies When Facilitating Field Study Science Observations, Steph Dean, Devin A. Jones
An Examination Of Educators’ Approaches And Strategies When Facilitating Field Study Science Observations, Steph Dean, Devin A. Jones
Publications
The untapped potential of field study science is not being fully recognized or explored within the United States despite the recorded benefits of outdoor learning within K-12 settings. This research study contributes to the broader understanding of the affordances of field study science as an essential component of science education by investigating the approaches teachers adopt when facilitating scientific observations in an outdoor setting as well as specific strategies that support implementation. Engaging in qualitative content analysis allowed us to consider the descriptive concepts represented within K-12 teachers’ narratives as we determined patterns within the transcript documents. Seven themes were …
Curbing The Campus Mental Health Crisis: The Role Of Extracurricular Activity Participation, Rosanne Villemaire-Krajden, Erin Barker
Curbing The Campus Mental Health Crisis: The Role Of Extracurricular Activity Participation, Rosanne Villemaire-Krajden, Erin Barker
Journal of Youth Development
Rates of distress on post-secondary campuses are alarmingly high, calling for a shift towards learning environments that better address emerging adults’ holistic needs. This cross-sectional, mixed-method study examines the role that extracurricular activity participation can play in such approaches. Online survey data was collected from 302 undergraduate students (Mage = 21.3) to assess extracurricular activity participation prior to and during their university attendance, across quantitative indicators (i.e., type and number of activities). Students’ qualitative accounts of the influence of their extracurricular activity participation on their development and wellbeing was examined using thematic analysis. Results indicate that rates of …
Volunteer Training, Tenure, And Facilitation Of Essential Elements In 4-H: Examining Conditions That Promote Positive Youth Development Practices, Kimber Sarver, Kate Fogarty, Tracy Johns, Sarah Thomas Hensley, Dale W. Pracht
Volunteer Training, Tenure, And Facilitation Of Essential Elements In 4-H: Examining Conditions That Promote Positive Youth Development Practices, Kimber Sarver, Kate Fogarty, Tracy Johns, Sarah Thomas Hensley, Dale W. Pracht
Journal of Youth Development
The 4-H program relies on trained volunteers to facilitate youths’ acquisition of life skills in relevant subject matter areas (STEM, Healthy Living). A large part of the 4-H professionals’ objective is to undergird their volunteers in program delivery. The content of volunteers’ training emphasizes the 4 essential elements for youth development programming, namely: 1. Creating an atmosphere of belonging for diverse youth; 2. Promoting generosity through service to their families and communities; 3. Supporting youth mastery of globally applicable life skills and specific skills within subject matter areas of expertise; and 4. Facilitating youths’ sense of independence by self-selecting topics …
A Comparative Evaluation Of Two Youth Mental Health Trainings For Volunteers, Monica M. Lobenstein, Shannon Sparks, Jennifer Park-Mroch, Danette Hopke, Jayna Hintz, Megan Suehring, Kea Norrell-Aitch, Karla Gearing, Michelle Gobert, Sheila Michels
A Comparative Evaluation Of Two Youth Mental Health Trainings For Volunteers, Monica M. Lobenstein, Shannon Sparks, Jennifer Park-Mroch, Danette Hopke, Jayna Hintz, Megan Suehring, Kea Norrell-Aitch, Karla Gearing, Michelle Gobert, Sheila Michels
Journal of Youth Development
Adolescence is a critical period for developing social and emotional habits important for mental well-being (Kessler et al., 2005). Half of all mental health conditions start by age 14, and the average delay between onset of symptoms and intervention is eight to ten years (Wang et al., 2007). Youth with mental health conditions are particularly vulnerable to social exclusion, discrimination, stigma, educational difficulties, risk-taking behaviors, and worsening physical health. Youth often do not get the help they need due to ongoing stigma and barriers in accessing mental health treatment. For example, in Wisconsin, 30% of the population live in a …
Can Nutrition Education Reduce Division Iii Female Athlete's Risk Of Developing Low Energy Availability, Coby Stover
Can Nutrition Education Reduce Division Iii Female Athlete's Risk Of Developing Low Energy Availability, Coby Stover
Masters Theses/Capstone Projects
Context: Low Energy availability (LEA) is widely acknowledged as a state in which an individual does not have sufficient energy to support normal functions within the body after energy has been expended through exercise. In sports environments, athletes can exhibit LEA for a variety of reasons. These reasons range from improper food intake to effectively fuel and re-fuel their body for the energy demands of their specific sport, to eating disorders (ED) and eating disorder behaviors. Access to appropriate nutrition knowledge is also a major factor that can place athletes at risk for developing LEA. Both males and females …
Review Of "Where Sight Meets Sound: The Poetics Of Late-Medieval Music Writing" By E. Zazulia, James J. Blasina
Review Of "Where Sight Meets Sound: The Poetics Of Late-Medieval Music Writing" By E. Zazulia, James J. Blasina
Music Faculty Works
No abstract provided.
Thermal Hydraulic Analysis For Different Subchannels Of Generic Vver-1200, Mosaddak Ahamed Zahid, Md. Imam Mehedi, Shamsul Arefin Shibly, A. S. Mollah
Thermal Hydraulic Analysis For Different Subchannels Of Generic Vver-1200, Mosaddak Ahamed Zahid, Md. Imam Mehedi, Shamsul Arefin Shibly, A. S. Mollah
International Journal of Nuclear Security
The demand for nuclear energy is steadily increasing all over the world. Most nuclear power is used for peaceful applications such as power generation, healthcare, agriculture, food security, industry, and research. One of the primary applications of nuclear energy is the generation of electricity through nuclear power plants based on nuclear reactors. Many developing countries around the world (such as Bangladesh) are moving toward nuclear power plants because they have huge advantages, including low-cost energy, reliable energy sources, zero carbon emissions, and high energy concentration. As a result, the demand for nuclear reactor protection and operational protection of nuclear power …
A Survey Of Availability And Affordability Of Polypills For Cardiovascular Disease In Selected Countries, Gautam Satheesh, Bishal Gyawali, Marie France Chan Sun, Mark D Huffman, Amitava Banerjee, Pablo Perel, Adrianna Murphy
A Survey Of Availability And Affordability Of Polypills For Cardiovascular Disease In Selected Countries, Gautam Satheesh, Bishal Gyawali, Marie France Chan Sun, Mark D Huffman, Amitava Banerjee, Pablo Perel, Adrianna Murphy
2020-Current year OA Pubs
BACKGROUND: The recent inclusion of polypills-fixed-dose combinations of antihypertensive medicines and a statin with or without aspirin-in the World Health Organization's Essential Medicines List (EML) reiterates the potential of this approach to improve global treatment coverage for cardiovascular diseases (CVDs). Although there exists extensive evidence on the effectiveness, safety and acceptability of polypills, there has been no research to date assessing the real-world availability and affordability of polypills globally.
METHODS: We conducted a cross-sectional survey, based on the WHO/Health Action International methodology, in 13 countries around the world. In the surveyed countries, we first ascertained whether any polypill was authorised …
Epigenetic Developmental Mechanisms Underlying Sex Differences In Cancer, Joshua B. Rubin, Tamara Abou-Antoun, Joseph E. Ippolito, Lorida Llaci, Camryn T. Marquez, Jason P. Wong, Lihua Yang
Epigenetic Developmental Mechanisms Underlying Sex Differences In Cancer, Joshua B. Rubin, Tamara Abou-Antoun, Joseph E. Ippolito, Lorida Llaci, Camryn T. Marquez, Jason P. Wong, Lihua Yang
2020-Current year OA Pubs
Cancer risk is modulated by hereditary and somatic mutations, exposures, age, sex, and gender. The mechanisms by which sex and gender work alone and in combination with other cancer risk factors remain underexplored. In general, cancers that occur in both the male and female sexes occur more commonly in XY compared with XX individuals, regardless of genetic ancestry, geographic location, and age. Moreover, XY individuals are less frequently cured of their cancers, highlighting the need for a greater understanding of sex and gender effects in oncology. This will be necessary for optimal laboratory and clinical cancer investigations. To that end, …
A Phase Ii Trial Of The Wee1 Inhibitor Adavosertib In Setd2-Altered Advanced Solid Tumor Malignancies (Nci 10170), Edward Maldonado, Nikolaos A Trikalinos, Et Al.
A Phase Ii Trial Of The Wee1 Inhibitor Adavosertib In Setd2-Altered Advanced Solid Tumor Malignancies (Nci 10170), Edward Maldonado, Nikolaos A Trikalinos, Et Al.
2020-Current year OA Pubs
UNLABELLED: We sought to evaluate the efficacy of WEE1 inhibitor adavosertib in patients with solid tumor malignancies (cohort A) and clear cell renal cell carcinoma (ccRCC; cohort B). NCT03284385 was a parallel cohort, Simon two-stage, phase II study of adavosertib (300 mg QDAY by mouth on days 1-5 and 8-12 of each 21-day cycle) in patients with solid tumor malignancies harboring a pathogenic SETD2 mutation. The primary endpoint was the objective response rate. Correlative assays evaluated the loss of H3K36me3 by IHC, a downstream consequence of SETD2 loss, in archival tumor tissue. Eighteen patients were enrolled (9/cohort). The median age …
Risk Factors For Postpartum Depression And Severe Distress Among Mothers Of Very Preterm Infants At Nicu Discharge., Julie A. Hofheimer, Elisabeth C. Mcgowan, Lynne M. Smith, Samantha Meltzer-Brody, Brian S. Carter, Lynne M. Dansereau, Steven Pastyrnak, Jennifer B. Helderman, Charles R. Neal, Sheri A. Dellagrotta, Thomas Michael D O'Shea, Barry M. Lester
Risk Factors For Postpartum Depression And Severe Distress Among Mothers Of Very Preterm Infants At Nicu Discharge., Julie A. Hofheimer, Elisabeth C. Mcgowan, Lynne M. Smith, Samantha Meltzer-Brody, Brian S. Carter, Lynne M. Dansereau, Steven Pastyrnak, Jennifer B. Helderman, Charles R. Neal, Sheri A. Dellagrotta, Thomas Michael D O'Shea, Barry M. Lester
Manuscripts, Articles, Book Chapters and Other Papers
OBJECTIVE: To identify psychological, medical, and socioenvironmental risk factors for maternal postpartum depression (PPD) and severe psychological distress (SPD) at intensive care nursery discharge among mothers of very preterm infants.
STUDY DESIGN: We studied 562 self-identified mothers of 641 infants born(NOVI) conducted in nine university-affiliated intensive care nurseries. Enrollment interviews collected socioenvironmental data, depression, and anxiety diagnoses prior to and during the study pregnancy. Standardized medical record reviews ascertained prenatal substance use, maternal and neonatal medical complications. The Edinburgh Postnatal Depression Scale and Brief Symptom Inventory were administered at nursery discharge to screen for PPD and SPD symptoms, respectively.
RESULTS: …
Psychotropic Medication Usage In Pediatric Ckd: Reporting From The Ckd In Children Cohort., Ryan C. Ward, Amy J. Kogon, Matthew B. Matheson, Anne Dawson, Stephen R. Hooper, Stephen Molitor, Cynthia Wong, Susan L. Furth, Bradley A. Warady, Lyndsay A. Harshman
Psychotropic Medication Usage In Pediatric Ckd: Reporting From The Ckd In Children Cohort., Ryan C. Ward, Amy J. Kogon, Matthew B. Matheson, Anne Dawson, Stephen R. Hooper, Stephen Molitor, Cynthia Wong, Susan L. Furth, Bradley A. Warady, Lyndsay A. Harshman
Manuscripts, Articles, Book Chapters and Other Papers
Background: Mental health disorders within the pediatric CKD population are prevalent. The frequency is unknown with which psychotropic medications that commonly treat these conditions are used in this population.
Methods: Data from the CKD in Children (CKiD) cohort study were used to describe the use of psychotropic medications and patient-related characteristics of use. Medications were classified into three groups: antidepressants, central nervous system (CNS) stimulants, and antipsychotic/mood stabilizing medications. Participant age, sex, CKD severity, and duration of medication use were ascertained. Medication use was evaluated in parallel with CKD disease type, presence of urological comorbidity, and hypertension. Chi-square tests compared …
Metalogues, Robert Kelly
July 2024, Robert Kelly
Inpatient Staff Perspective On Verbal De-Escalation Within A High Acuity Population, Giovanna Dezutti
Inpatient Staff Perspective On Verbal De-Escalation Within A High Acuity Population, Giovanna Dezutti
Dissertations
This study explored inpatient staff’s perspective of verbal de-escalation within a high acuity population as well as the factors that make either a positive or negative impact on the effectiveness of verbal de-escalation as used in high acuity impatient settings. This phenomenological study used semi-structured interviews of 5 participants working in this setting. Participants were recruited through snowball sampling, and interviews were conducted via zoom. This study found that participants unanimously agreed that the training they received regarding verbal de-escalation was not sufficient and that employment of certain personality traits and behaviors were more effective than using only the methods …
A Qualitative Study Exploring The Management & Implications Of Power Differentials Experienced By Pre-Licensed Supervisees In Clinical Supervision Settings, Joyti Jariwala
Dissertations
The focus in this qualitative study was to explore how power differentials in supervision create positive and negative experiences between licensed psychologists and pre-licensed doctoral students. The study results provide insight into how supervisees navigate these dynamics during supervision, which typically involves experiential learning environments in which trainees discuss progress, receive feedback, and enhance their skills. The theoretical framework grounding the study was social learning theory, which is based on the idea that individuals learn from modeling, observation, and imitation in a social context (Bandura, 1986). Reflexive thematic analysis was used to recognize similarities in findings gathered via two sets …
Generation Z’S Perspective On Work-Life Balance: Case Of Kosovo, Lorine Bajrami
Generation Z’S Perspective On Work-Life Balance: Case Of Kosovo, Lorine Bajrami
Theses
This capstone project examines the perspective of Generation Z in Kosovo toward work-life balance by specifically looking at their preferences regarding flexibility, remote work, and the compromise of work-life balance with other work-related factors. People who are born between 1996 and 2010 belong to the Generation Z cohort, which is characterized by profound digital savviness, mental health awareness, preference for flexibility in workplace, and strong desire to balance work and personal life. The data for analyzing the Gen Z’s perspectives on life work-balance is collected through an online survey (n=174) and two focus group discussions. Global reports and existing research …
Impacts Of Professional Development On Researchers, Kayleigh M. Patterson
Impacts Of Professional Development On Researchers, Kayleigh M. Patterson
Theses
In this work, I study the effectiveness of Professional development for Emerging Education Researchers (PEER) using a framework adapted from one that evaluates professional development for teachers. Professional Development (PD) is the process of learning information after one’s main school for job settings. These cover job/career specific skills that are not taught during schooling, since they are normally more specific. While a Ph.D. does set up a lot of specific skills, due to a changing research climate based on discoveries and organizational standards, there are always more skills to learn for a researcher. Therefore, there are professional development for researchers …
Feasibility Of Simulation Free Abdominal Stereotactic Adaptive Radiotherapy Using An Expedited Pre-Plan Workflow, Alex T Price, Joshua P Schiff, Alice Silberstein, Robbie Beckert, Tianyu Zhao, Geoffrey D Hugo, Pamela P Samson, Eric Laugeman, Lauren E Henke
Feasibility Of Simulation Free Abdominal Stereotactic Adaptive Radiotherapy Using An Expedited Pre-Plan Workflow, Alex T Price, Joshua P Schiff, Alice Silberstein, Robbie Beckert, Tianyu Zhao, Geoffrey D Hugo, Pamela P Samson, Eric Laugeman, Lauren E Henke
2020-Current year OA Pubs
BACKGROUND AND PURPOSE: Improved hounsfield-unit accuracy of on-board imaging may lead to direct-to-unit treatment approaches We aimed to demonstrate the feasibility of using only a diagnostic (dx) computed tomography (CT)-defined target pre-plan in an
MATERIALS AND METHODS: Eight patients with abdominal treatment sites (five pancreatic cancer, three oligometastases) were treated using an integrated adaptive O-Ring gantry system. Each patient's target was delineated on a dxCT. The target only pre-plan served primarily to seed the ART process. During the ART session, all structures were delineated. All simulated cases were treated to 50 Gy in 5 fractions to a planning target optimization …
Phase 1b Study To Assess The Safety, Tolerability, And Clinical Activity Of Pamiparib In Combination With Temozolomide In Patients With Locally Advanced Or Metastatic Solid Tumors, Agostina Stradella, Haeseong Park, Et Al.
Phase 1b Study To Assess The Safety, Tolerability, And Clinical Activity Of Pamiparib In Combination With Temozolomide In Patients With Locally Advanced Or Metastatic Solid Tumors, Agostina Stradella, Haeseong Park, Et Al.
2020-Current year OA Pubs
BACKGROUND: Pamiparib is a potent, selective, poly (ADP-ribose) polymerase 1/2 inhibitor that demonstrates synthetic lethality in cells with breast cancer susceptibility gene mutations or other homologous recombination deficiency. This two-stage phase 1b study (NCT03150810) assessed pamiparib in combination with temozolomide (TMZ) in adult patients with histologically confirmed locally advanced and metastatic solid tumors.
METHODS: Oral pamiparib 60 mg was administered twice daily. During the dose-escalation stage, increasing doses of TMZ (40-120 mg once daily pulsed or 20-40 mg once daily continuous) were administered to determine the recommended dose to be administered in the dose-expansion stage. The primary objectives were to …