Digital Commons Network^™

Cluster-Based Toxicity Estimation Of Osteoradionecrosis Via Unsupervised Machine Learning: Moving Beyond Single Dose-Parameter Normal Tissue Complication Probability By Using Whole Dose-Volume Histograms For Cohort Risk Stratification, Seyedmohammadhossein Hosseinian, Mehdi Hemmati, Cem Dede, Travis C Salzillo, Lisanne V Van Dijk, Stephen Y Lai, Clifton D Fuller

Faculty, Staff and Student Publications

PURPOSE: Given the limitations of extant models for normal tissue complication probability estimation for osteoradionecrosis (ORN) of the mandible, the purpose of this study was to enrich statistical inference by exploiting structural properties of data and provide a clinically reliable model for ORN risk evaluation through an unsupervised-learning analysis that incorporates the whole radiation dose distribution on the mandible.

METHODS AND MATERIALS: The analysis was conducted on retrospective data of 1259 patients with head and neck cancer treated at The University of Texas MD Anderson Cancer Center between 2005 and 2015. During a minimum 12-month posttherapy follow-up period, 173 patients …

A Biallelic Variant Of The Rna Exosome Gene, Exosc4, Associated With Neurodevelopmental Defects Impairs Rna Exosome Function And Translation, Milo B Fasken, Sara W Leung, Lauryn A Cureton, Maha Al-Awadi, Adila Al-Kindy, Sohail Khoshnevis, Almundher Al-Maawali, Anita H Corbett

Faculty, Staff and Student Publications

The RNA exosome is an evolutionarily conserved complex required for both precise RNA processing and decay. Pathogenic variants in EXOSC genes, which encode structural subunits of this complex, are linked to several autosomal recessive disorders. Here, we describe a missense allele of the EXOSC4 gene that causes a collection of clinical features in two affected siblings. This missense variant (NM_019037.3: exon3:c.560T>C) changes a leucine residue within a conserved region of EXOSC4 to proline (p.Leu187Pro). The two affected individuals show prenatal growth restriction, failure to thrive, global developmental delay, intracerebral and basal ganglia calcifications, and kidney failure. Homozygosity for the …

Updated Understanding Of The Protein-Dna Recognition Code Used By C2h2 Zinc Finger Proteins, Xing Zhang, Robert M Blumenthal, Xiaodong Cheng

Faculty, Staff and Student Publications

C2H2 zinc-finger (ZF) proteins form the largest family of DNA-binding transcription factors coded by mammalian genomes. In a typical DNA-binding ZF module, there are twelve residues (numbered from -1 to -12) between the last zinc-coordinating cysteine and the first zinc-coordinating histidine. The established C2H2-ZF "recognition code" suggests that residues at positions -1, -4, and -7 recognize the 5', central, and 3' bases of a DNA base-pair triplet, respectively. Structural studies have highlighted that additional residues at positions -5 and -8 also play roles in specific DNA recognition. The presence of bulky and either charged or polar residues at these five …

Patient-Derived Organoids As Therapy Screening Platforms In Cancer Patients, Danial Khorsandi, Jia-Wei Yang, Samuel Foster, Safoora Khosravi, Negar Hosseinzadeh Kouchehbaghi, Yun Bin Lee, Ankit Gangrade, Leon Voskanian, Darbaz Adnan, Yangzhi Zhu, Zhaohui Wang, Vadim Jucaud, Mehmet Remzi Dokmeci, Xiling Shen, Faraz Bishehsari, Jonathan A Kelber, Ali Khademhosseini, Natan Roberto De Barros

Faculty, Staff and Student Publications

Patient-derived organoids (PDOs) developed ex vivo and in vitro are increasingly used for therapeutic screening. They provide a more physiologically relevant model for drug discovery and development compared to traditional cell lines. However, several challenges remain to be addressed to fully realize the potential of PDOs in therapeutic screening. This paper summarizes recent advancements in PDO development and the enhancement of PDO culture models. This is achieved by leveraging materials engineering and microfabrication technologies, including organs-on-a-chip and droplet microfluidics. Additionally, this work discusses the application of PDOs in therapy screening to meet diverse requirements and overcome bottlenecks in cancer treatment. …

Perioperative Nivolumab Versus Observation In Patients With Renal Cell Carcinoma Undergoing Nephrectomy (Prosper Ecog-Acrin Ea8143): An Open-Label, Randomised, Phase 3 Study, Mohamad E Allaf, Se-Eun Kim, Viraj Master, David F Mcdermott, Lauren C Harshman, Charles G Drake, Mahmut Akgul, Nicholas Baniak, Elsa Li-Ning, Matthew B Palmer, Hamid Emamekhoo, Nabil Adra, Hristos Kaimakliotis, Yasser Ged, Phillip M Pierorazio, E Jason Abel, Mehmet A Bilen, Kenneth Ogan, Helen H Moon, Krishna A Ramaswamy, Eric A Singer, Tina M Mayer, Jay Lohrey, Vitaly Margulis, Jessie Gills, Scott E Delacroix, Mark J Waples, Andrew C James, Peng Wang, Toni Choueiri, M Dror Michaelson, Anil Kapoor, Daniel Y Heng, Brian Shuch, Bradley C Leibovich, Primo N Lara, Judith Manola, Deborah Maskens, Dena Battle, Robert Uzzo, Gennady Bratslavsky, Naomi B Haas, Michael A Carducci

Faculty, Staff and Student Publications

Background: The standard of care for patients with intermediate-to-high risk renal cell carcinoma is partial or radical nephrectomy followed by surveillance. We aimed to investigate use of nivolumab before nephrectomy followed by adjuvant nivolumab in patients with high-risk renal cell carcinoma to determine recurrence-free survival compared with surgery only.

Methods: In this open-label, randomised, phase 3 trial (PROSPER EA8143), patients were recruited from 183 community and academic sites across the USA and Canada. Eligible patients were aged 18 years or older with an Eastern Cooperative Oncology Group performance status of 0-1, with previously untreated clinical stage T2 or greater or …

Simulation-Based Caregiving Skills Training For Family Members Of High-Grade Glioma Patients, Meagan Whisenant, Shiao-Pei Weathers, Yisheng Li, Ellen Aldrich, Kristin Ownby, An Ngo-Huang, Kathrin Milbury

Faculty, Staff and Student Publications

BACKGROUND: Because family caregivers of patients with a high-grade glioma experience high levels of distress and feel unprepared to perform the complex caregiving tasks associated with the disease and its treatment, we pilot-tested a caregiving skills intervention that integrates hands-on caregiving with coping skill training.

METHODS: In this single-arm trial, caregivers participated in a 4-session research nurse-led intervention involving simulation-based caregiving skills training at the hospital and psychoeducation delivered via videoconference. We collected measures of patients' and caregivers' psychological symptoms; caregivers' caregiving self-efficacy and role adjustment; and patients' cancer-related symptoms (MDASI) at baseline and again postintervention. We tracked feasibility data. …

Adverse Childhood Experiences And Adult Household Firearm Ownership, Alexander Testa, Karyn Fu, Dylan B Jackson, Daniel C Semenza, Sandra Mckay

Faculty, Staff and Student Publications

This survey study examines exposure to abuse, neglect, and household dysfunction during childhood and likelihood of gun ownership in adulthood.

Settingsorder Article Reprints Open Accessarticle A Model To Account For The Effects Of Load Ratio And Hydrogen Pressure On The Fatigue Crack Growth Behavior Of Pressure Vessel Steels, Ashok Saxena, Kip O. Findley

Mechanical Engineering Faculty Publications and Presentations

A phenomenological model for estimating the effects of load ratio R and hydrogen pressure P_H2 on the hydrogen-assisted fatigue crack growth rate (HA-FCGR) behavior in the transient and steady-state regimes of pressure vessel steels is described. The "transient regime" is identified with crack growth within a severely embrittled zone of intense plasticity at the crack tip. The "steady-state" behavior is associated with the crack growing into a region of comparatively lower hydrogen concentration located further away from the crack tip. The model treats the effects of R and P_H2 as being functionally separable. In the transient …

Multimodal Boiling Dataset With Synchronized Acoustic, Optical, And Thermal Measurements Under Steady-State And Transient Heat Loads, Hari Pandey, Changgen Li, Han Hu

Mechanical Engineering Faculty Publications and Presentations

Boiling is a high-performance heat dissipation process that is central to electronics cooling and power generation. However, there exists a practical limit of boiling heat transfer known as the critical heat flux (CHF), beyond which significant performance degradation is observed. Understanding the physical mechanism that triggers CHF is essential to meet the increasing cooling demands driven by power densification and device miniaturization. However, the high dimensionality, stochasticity, and dynamicity of the boiling process have led to strong challenges in the experimental characterization and modeling of boiling CHF. As such, high-frame rate, high-resolution, multi-physics boiling datasets are critical to advancing the …

Therapeutic Decisions And Implications In Patients With Attention Deficit Hyperactivity Disorder Versus Bipolar Disorder: Key Insights For Clinicians

Faculty, Staff and Student Publications

Attention deficit hyperactivity disorder (ADHD) and pediatric bipolar disorder (BD) are conditions that often manifest in childhood and can persist into adulthood. Due to the similarities in their clinical presentations, it is crucial for clinicians to have a thorough understanding of these disorders. Accurate differentiation of symptoms is essential for making precise diagnoses, as this directly influences treatment decisions and affects the overall functioning and quality of life of those impacted. Considered here is the case of a teenage male who initially presented with impulsivity and was diagnosed with ADHD. However, upon further evaluation, his diagnosis was revised to BD. …

Prognostic Factors On Preoperative Mri For Patient-Reported Outcomes After Posterior Medial Meniscus Root Repair, Sergio E Flores, Rawee Manatrakul, Christopher Anigwe, Chotigar Ngarmsrikam, Brian T Feeley, C Benjamin Ma, Thomas M Link, Drew A Lansdown

Faculty, Staff and Student Publications

Background: Repair of posterior medial meniscus root (PMMR) tears has demonstrated favorable outcomes and may prevent rapid progression of knee osteoarthritis; however, there is a paucity of data regarding prognostic factors affecting postoperative outcomes.

Purpose/hypothesis: The purpose of this study was to identify factors on preoperative magnetic resonance imaging (MRI) that predict postoperative outcomes after PMMR repair. It was hypothesized that patients with increasing levels of degenerative changes as evaluated through semiquantitative preoperative MRI scans would have worse postoperative patient-reported outcome (PRO) scores.

Study design: Cohort study; Level of evidence, 3.

Methods: Patients who underwent PMMR repair between 2012 and …

Structure And Function Are Not The Same: The Case For Restoring Mechanoreceptor Continuity Following Anterior Cruciate Ligament Injury, Braden C Fleming

Faculty, Staff and Student Publications

Anterior cruciate ligament (ACL) injury, particularly in increasingly young and active adolescents, continues to pose a clinical challenge with re-injury rates reported as high as 30%. Evidence also suggests that current standard-of-care ACL reconstruction (ACLR) does not mitigate post-traumatic osteoarthritis (PTOA) risk. Bridge- enhanced ACL restoration (BEAR) is a recently developed and tested ACL surgery that promotes primary healing of the native ACL with excellent early results. BEAR has shown to reduce signs of early PTOA compared to ACLR in an animal model. Here, we describe a theoretical framework related to re-innervation that can clarify why the outcomes of ACLR …

Shared Delusion: Impact On The Parent-Child Relationship

Faculty, Staff and Student Publications

Folie à famille, also known as shared psychotic disorder among family members, is a rare and underdiagnosed psychiatric condition. This disorder, seldom discussed in the literature, is particularly notable for its impact on clinical management and parent-child relationships. The few reported cases have predominantly focused on adult populations, leaving a significant gap in understanding how this condition manifests and affects younger individuals and family dynamics. One area that remains largely unexplored in the literature is the intersection between attachment patterns and shared psychosis, particularly in the context of parent-child relationships. Understanding this intersection is crucial, as it can provide insights …

African American Patients Have A Higher Probability Of Cognitive Impairment After Incident Stroke: An Analysis Of National Electronic Health Record Data, Sahar Anjum

Faculty, Staff and Student Publications

Background: Cognitive impairment (CI) and stroke are diseases with significant disparities in race and geography. Post stroke cognitive impairment (PSCI) can be as high as 15-70 % but few studies have utilized large administrative or electronic health records (EHR) to evaluate trends in PSCI. We utilized an EHR database to evaluate for disparities in PSCI in a large sample of patients after first recorded stroke to evaluate for disparities in race.

Methods: This is a retrospective cohort analysis of Cerner Health Facts® EHR database, which is comprised of EHR data from hundreds of hospitals/clinics in the US from 2009-2018. We …

4d Dynamic Spatial Brain Networks At Rest Linked To Cognition Show Atypical Variability And Coupling In Schizophrenia, Peter Kochunov

Faculty, Staff and Student Publications

Despite increasing interest in the dynamics of functional brain networks, most studies focus on the changing relationships over time between spatially static networks or regions. Here we propose an approach to study dynamic spatial brain networks in human resting state functional magnetic resonance imaging (rsfMRI) data and evaluate the temporal changes in the volumes of these 4D networks. Our results show significant volumetric coupling (i.e., synchronized shrinkage and growth) between networks during the scan, that we refer to as dynamic spatial network connectivity (dSNC). We find that several features of such dynamic spatial brain networks are associated with cognition, with …

A Qualitative Narrative Study Of Rescue And Recovery Workers Responding To The Terrorist Bombing Of Oklahoma City's Murrah Building, E Whitney Pollio, Jennifer Wang, Edward Randle, David E Pollio, Carol S North

Faculty, Staff and Student Publications

OBJECTIVE: Much of disaster mental health research uses quantitative methods, focusing on numerical prevalence, services, and outcomes.

METHODS: Qualitative methods can provide more detailed, rich, and spontaneous insights into personal disaster experiences, yielding important insights beyond deductive methods. This large-scale qualitative narrative study examined experiences of 181 Oklahoma City bombing rescue/recovery workers.

RESULTS: Thematic narrative content of the bombing experience arose from personal accounts of the bomb blast by rescue/recovery workers proceeding chronologically from initial awareness and deployment to harrowing onsite search and rescue/recovery missions to the aftermath with reflections on the bombing.

CONCLUSIONS: Beyond disaster recovery/rescue worker stories published …

The Harms Of Imprisonment And Envisioning A Desistance-Supporting ‘Good Society’, Patricia Gray, Julie Parsons

School of Law, Humanities and Social Sciences

Research evidence in the 21st century strongly indicates that prisons are inherently harmful environments in which to try to support rehabilitation, because of their destructive impact on identity, self-actualisation, mental health and social relationships. Yet HM Prison and Probation Service (HMPPS) continues to propose that prisons can be legitimate sites of rehabilitation as well as centres of punishment. This article begins by interrogating this proposition by looking at research conducted in an adult male prison. By specifically focusing on the interpersonal conflicts and tensions that the men experience in their daily lives, the research highlights the ‘relational’ and ‘self-actualising’ harms …

Scotland In The Forefront Of Property Law Reforms In The Uk: Potential Implications For The Scottish People, Goodtime Okara

School of Law, Humanities and Social Sciences

The Scottish Government has taken steps to revolutionise its body of law on ‘trust and succession’ and housing. The recent Trusts and Succession (Scotland) Act 2024 has severally impacted the issues of appointment and removal of trustees, fiduciary duties of trustees, rights of beneficiaries, and Environmental, Social, and Governance (ESG) investments in Scotland; while the proposed new Housing (Scotland) Bill 2024 has the proclivity of influencing rent, rent control areas, eviction and homelessness in Scotland. Accordingly, this paper focuses on exploring the potential impacts of these legislative reforms on the lives of the Scottish people. Do they ‘make’ or ‘mar’ …

Complementary Classifications Of Aeolian Dunes Based On Morphology, Dynamics, And Fluid Mechanics, Sylvain Courrech Du Pont, David M. Rubin, Clément Narteau, Mathieu G.A. Lapôtre, Mackenzie Day, Philippe Claudin, Ian Livingstone, Matt W. Telfer, Jani Radebaugh, Cyril Gadal, Andrew Gunn, Patrick A. Hesp, Sabrina Carpy, Charles S. Bristow, Andreas C.W. Baas, Ryan C. Ewing, Giles F.S. Wiggs

School of Geography, Earth and Environmental Sciences

Dunes form where winds blow over a bed of mobile sediment grains — conditions that are common in our solar system. On Earth, dunes abound in arid continental interiors and along sandy coastlines. Dune fields have also been recognized on Venus, Mars, Saturn’s moon Titan, and Pluto. In response to the different boundary conditions and other environmental forcings, dunes adopt a rich diversity of shapes, sizes, and behaviors. Thus, people around the globe and over centuries have developed a rich vocabulary to describe dunes and their complexity. As a result, existing dune nomenclature often includes redundant terms with differing definitions …

New Geographies Of Crime? Cybercrime, Southern Criminology And Diversifying Research Agendas, Tim Hall, Richard Yarwood

School of Geography, Earth and Environmental Sciences

This paper argues that reconsidering the disciplinary significance of the geographies of crime is timely. It has three aims. First, it identifies recent developments in the geographical study of crime, arguing that they both challenge and extend its intellectual traditions. Second, using the example of cybercrime, it identifies new forms of crime that deserve scrutiny by geographers. Third, it draws on ideas of Southern criminology to identify how research agendas can be diversified to advance how geographers study crime. In doing so it proposes that geographers’ renewed interest in crime over recent decades is appropriately labelled ‘new geographies of crime’.

An Atypical Form Of 60s Ribosomal Subunit In Diamond-Blackfan Anemia Linked To Rpl17 Variants., Florence Fellmann, Carol J. Saunders, Marie-Françoise O'Donohue, David W. Reid, Kelsey A. Mcfadden, Nathalie Montel-Lehry, Cong Yu, Mingyan Fang, Jianguo Zhang, Beryl Royer-Bertrand, Pietro Farinelli, Narjesse Karboul, Jason R. Willer, Lorraine Fievet, Zahurul Alam Bhuiyan, Alissa Lw Kleinhenz, Julie Jadeau, Joy M. Fulbright, Carlo Rivolta, Raffaele Renella, Nicholas Katsanis, Jacques S. Beckmann, Christopher V. Nicchitta, Lydie Da Costa, Erica E. Davis, Pierre-Emmanuel Gleizes

Manuscripts, Articles, Book Chapters and Other Papers

Diamond-Blackfan anemia syndrome (DBA) is a ribosomopathy associated with loss-of-function variants in more than 20 ribosomal protein (RP) genes. Here, we report the genetic, functional, and biochemical dissection of 2 multigenerational pedigrees with variants in RPL17, a large ribosomal subunit protein-encoding gene. Affected individuals had clinical features and erythroid proliferation defects consistent with DBA. Further, RPL17/uL22 depletion resulted in anemia and micrognathia in zebrafish larvae, and in vivo complementation studies indicated that RPL17 variants were pathogenic. Lymphoblastoid cell lines (LCLs) derived from patients displayed a ribosomal RNA maturation defect reflecting haploinsufficiency of RPL17. The proteins encoded by RPL17 variants were …

Development Of Multifunctional Biobased Lubricants From Soybean Oil And Their Tribological Behavior, Piash Bhowmik

Theses and Dissertations

Depletion of mineral oil leads the researchers to look for renewable oils recently. Soybean, which is one of the most produced crops globally, has been identified as a potential source for such oil. The problem with vegetable oils is, they consist of unsaturated fatty acids which leads to oxidation of the oils. With proper modification and the use of suitable additives, these oils can be adapted for use in various sectors. High oleic oils are becoming increasingly popular due to their high oleic acid content, which is a monounsaturated fatty acid. These oils are gaining attention for their improved stability …

Msw Portfolio Paper, Kortni Sims

Graduate Student Portfolios, Professional Papers, and Capstone Projects

This portfolio paper integrates personal experiences with academic and professional development. She is reflecting on her progression as a social worker. The paper focuses on food security and social justice, examining the impact of systems theory and conflict theory in her practice. Sims demonstrates her proficiency in the ten social work competencies, highlighting her ability to engage in critical self-reflection and advocate for marginalized communities. The paper concludes with a reflection on her past, present, and future as an advanced integrated social worker, committed to ongoing personal and professional growth.

Msw Professional Portfolio, Michelle Davis

Graduate Student Portfolios, Professional Papers, and Capstone Projects

A comprehensive review of the professional development required for an advanced integrated social work practitioner.

Msw Portfolio, Elizabeth E. Robledo

Graduate Student Portfolios, Professional Papers, and Capstone Projects

The portfolio I constructed discusses how I have met the ten competencies and five elements of advanced integrated practices of social work practice.

Upscaling Relative Permeability And Capillary Pressure From Digital Core Analysis In Otway Formation: Considering The Order And Size Effects Of Facies, Masoud Aslannezhad, Mohammad Sayyafzadeh, David Tang, Zhenjiang You, Stefan Iglauer, Alireza Keshavarz

Research outputs 2022 to 2026

Digital Core Analysis (DCA) has emerged as a crucial instrument in reservoir characterization in recent times. With the advent of high-resolution micro-CT imaging, it is now possible to visualize the three-dimensional microstructures of in-situ pores and flow patterns within rocks. DCA offers several notable benefits over traditional techniques, such as a higher density of measurements, faster processing times, and the preservation of rock samples. It also demonstrates considerable flexibility with challenging core conditions and can derive numerous parameters from each individual sample. The objective of this work is to utilise DCA data from Otway formation to enhance reservoir characterisation and …

Fatigue Performance Of 3d-Printed Poly-Lactic-Acid Bone Scaffolds With Triply Periodic Minimal Surface And Voronoi Pore Structures, Hamed Bakhtiari, Alireza Nouri, Majid Tolouei-Rad

Research outputs 2022 to 2026

Bone scaffolds serve a crucial role in tissue engineering, particularly in facilitating bone regeneration where natural repair is insufficient. Despite advancements in the fabrication of polymeric bone scaffolds, the challenge remains to optimize their mechanical resilience. Specifically, research on the fatigue behaviour of polymeric bone scaffolds is scarce. This study investigates the influence of pore architecture on the mechanical performance of poly-lactic-acid (PLA) scaffolds under quasi-static and cyclic compression. PLA scaffolds with a 60% porosity were fabricated using extrusion-based 3D printing in various designs: Gyroid, Lidinoid, Fischer–Koch, IWP, and Voronoi. Results demonstrated that Gyroid scaffolds had the highest compressive strength …

Positive Association Between Patients’ Perception Of Chronic Pain Rehabilitation As A Personally Meaningful Experience And The Flourishing Aspect Of Well-Being, Katrina J. Liddiard, Cary A. Brown, Annette J. Raynor

Research outputs 2022 to 2026

Chronic pain rehabilitation helps to reduce pain and restore valued life roles. Patients may have more positive outcomes when they perceive rehabilitation to be personally meaningful. This study examined associations between self-reported, personally meaningful rehabilitation and well-being. A pilot study was conducted using an online survey of people with chronic pain and experiences of rehabilitation. The PROMIS Pain Interference Short Form 8a and The Flourishing Scale were used to explore well-being. A modified self-report measure, the Meaningfulness in Rehabilitation Scale, was pilot-tested for construct validity and used in the survey. Of the 48 participants (81% female; 19% male), most attended …

Magnetization And Age Of Ca. 544 Ma Syenite, Eastern Canada: Evidence For Renewal Of The Geodynamo, Tinghong Zhou, Mauricio Ibañez-Mejia, Richard K. Bono, Rory D. Cottrell, Wouter Bleeker, Kenneth P. Kodama, Wentao Huang, Eric G. Blackman, Francis Nimmo, Aleksey Smirnov, John A. Tarduno

Michigan Tech Publications

The ca. 565 Ma Ediacaran geodynamo was highly unusual, producing an ultralow field 10 times weaker than present-day value of 8 x 1022 A m2. A ∼5 times rise in field strength is seen in time-averaged single crystal paleointensity data of ca. 532 Ma Early Cambrian anorthosites of Oklahoma (USA). The field increase could record the onset of inner core nucleation predicted by thermal evolution and numerical dynamo models. Here, we examine the renewal of the geodynamo through zircon U-Pb geochronology and single crystal paleointensity studies of plagioclase from the Chatham-Grenville syenite intrusion in the Grenville Province (Canada). U-Pb data …

Atypical Brain Aging And Its Association With Working Memory Performance In Major Depressive Disorder, Natalie C.W. Ho, Richard A.I. Bethlehem, Jakob Seidlitz, Nikita Nogovitsyn, Paul Metzak, Pedro L. Ballester, Stefanie Hassel, Susan Rotzinger, Jordan Poppenk, John Blangero

Human Genetics Publications

Background: Patients with major depressive disorder (MDD) can present with altered brain structure and deficits in cognitive function similar to those seen in aging. However, the interaction between age-related brain changes and brain development in MDD remains understudied. In a cohort of adolescents and adults with and without MDD, we assessed brain aging differences and associations through a newly developed tool that quantifies normative neurodevelopmental trajectories. Methods: A total of 304 participants with MDD and 236 control participants without depression were recruited and scanned from 3 studies under the Canadian Biomarker Integration Network for Depression. Volumetric data were used to …