Digital Commons Network^™

Constraining The Dense Matter Equation Of State With New Nicer Mass–Radius Measurements And New Chiral Effective Field Theory Inputs, Nathan Rutherford, Melissa Mendes, Isak Svensson, Achim Schwenk, Anna L. Watts, Kai Hebeler, Jonas Keller, Chanda Prescod-Weinstein, Devarshi Choudhury, Geert Raaijmakers, Tuomo Salmi, Patrick Timmerman, Serena Vinciguerra, Sebastien Guillot, James M. Lattimer

Faculty Publications

Pulse profile modeling of X-ray data from the Neutron Star Interior Composition Explorer is now enabling precision inference of neutron star mass and radius. Combined with nuclear physics constraints from chiral effective field theory (χEFT), and masses and tidal deformabilities inferred from gravitational-wave detections of binary neutron star mergers, this has led to a steady improvement in our understanding of the dense matter equation of state (EOS). Here, we consider the impact of several new results: the radius measurement for the 1.42 M ⊙ pulsar PSR J0437−4715 presented by Choudhury et al., updates to the masses and radii of PSR …

Utilizing Unmanned Aerial Systems (Uas) And Computer Software To Assess Effects Of Cover Crops On Cash Crop Volumetric Mass And Plant Height, Carlos Andres Garcia Patlan

Theses and Dissertations

Sustainability in agriculture starts with the health of soil-- from its productivity and fertility, to its ability to retain water during droughts and allow for drainage during rain. One approach of improving soil health is the use of cover crops, a practice associated with improved nutrient availability in soils, the promotion of soil biodiversity and organic matter to improve density and structure, effective weed management, and ultimately improved yields of subsequent cash crops. Assessing the cumulative impacts of cover crops is difficult, with various metrics and indicators. Crop dry weight may be a way to predict the effects cover crops …

Intrinsic Universality In Tile Automata And Related Results, Elise C. Grizzell

Theses and Dissertations

The Tile Automata (TA) model describes self-assembly systems in which monomers can build structures and transition with an adjacent monomer to change their states. This paper shows that seeded TA is a non-committal intrinsically universal model of self-assembly. We present a single universal Tile Automata system containing approximately 4600 states that can simulate (a) the output assemblies created by any other Tile Automata system Γ, (b) the dynamics involved in building Γ’s assemblies, and (c) Γ’s internal state transitions. It does so in a non-committal way: it preserves the full non-deterministic dynamics of a tile’s potential attachment or transition by …

Benchmarking Machine Learning Algorithms For The Prediction Of Gas Adsorption In Metal-Organic Framework Materials, Juan G. Benitez

Theses and Dissertations

Metal-organic frameworks (MOFs) are nanoporous materials with a structure and chemistry that can be tailored with precision to support a variety of applications, such as gas storage, drug delivery, catalysis, and sensing. Central to the realization of these applications is the need to model adsorption in MOFs. However, if the goal is to screen a large number of the hundreds of thousands of MOFs discovered, conventional high-throughput molecular simulations are prohibitively demanding in terms of computational resources. Therefore, efficient approaches are required to efficiently identify suitable MOFs for specific applications. In our work, machine learning (ML) models to predict adsorption …

Coupling And Decoupling Of Ancestral Linkages And Current Cross-Border Economic Activities: Genetics And Policy, Suparna Chakraborty, Miao Grace Wang, M.C. Sunny Wong

Economics Faculty Research and Publications

This paper studies the potential link between the biological evolution of populations and present-day economic interactions by estimating the correlation of shared ancestry among populations with cross-border capital and human flows. To this end, we employ the new concept of genetic distance, based on (dis)similarity of neutral gene alleles, to quantify shared ancestry. We then incorporate the genetic distance measure into an augmented gravity model, traditionally used to analyze the effect of geographical distance on bilateral exchange. Our analysis focuses on bilateral foreign direct investment (FDI) and migration across 135 countries and we use both linear regression techniques as well …

Bigh3 Mediates Apoptosis And Gap Junction Failure In Osteocytes During Renal Cell Carcinoma Bone Metastasis Progression, Tianhong Pan, Fengshuo Liu, Xiaoxin Hao, Shubo Wang, Murtaza Wasi, Valerae O Lewis, Bryan Moon, Justin E Bird, Theocharis Panaretakis, Sue-Hwa Lin, Danielle Wu, Mary C Farach-Carson, Liyun Wang, Ningyan Zhang, Zhiqiang An, Xiang H-F Zhang, Robert L Satcher

Faculty, Staff and Student Publications

Renal cell carcinoma (RCC) bone metastatis progression is driven by crosstalk between tumor cells and the bone microenvironment, which includes osteoblasts, osteoclasts, and osteocytes. RCC bone metastases (RCCBM) are predominantly osteolytic and resistant to antiresorptive therapy. The molecular mechanisms underlying pathologic osteolysis and disruption of bone homeostasis remain incompletely understood. We previously reported that BIGH3/TGFBI (transforming growth factor-beta-induced protein ig-h3, shortened to BIGH3 henceforth) secreted by colonizing RCC cells drives osteolysis by inhibiting osteoblast differentiation, impairing healing of osteolytic lesions, which is reversible with osteoanabolic agents. Here, we report that BIGH3 induces osteocyte apoptosis in both human RCCBM tissue specimens …

A Randomised, Parallel-Group, Double-Blind, Placebo-Controlled Phase 3 Study To Determine The Effectiveness Of The Type I Interferon Receptor Antibody, Anifrolumab, In Systemic Sclerosis: Daisy Study Design And Rationale, Dinesh Khanna, Christopher P Denton, Shervin Assassi, Masataka Kuwana, Yannick Allanore, Christi Kleoudis, Eszter Csomor, Caroline Seo, Marius Albulescu, Raj Tummala, Hussein Al-Mossawi, Rubana N Kalyani, Francesco Del Galdo

Faculty, Staff and Student Publications

Objectives: The type I interferon pathway is a promising target for treatment of patients with systemic sclerosis (SSc). Here, we describe the design of a multinational, randomised phase 3 study to Determine the effectiveness of the type I interferon receptor antibody, Anifrolumab, In SYstemic sclerosis (DAISY).

Methods: DAISY includes a 52-week double-blind, placebo-controlled treatment period, a 52-week open-label active treatment period, and a 12-week safety follow-up period. The patient population includes a planned 306 adults with limited or diffuse cutaneous active SSc who satisfied American College of Rheumatology/European Alliance of Associations for Rheumatology 2013 SSc criteria. Use of standard immunosuppressants, …

Patient Education Practices And Preferences Of Radiation Oncologists And Interprofessional Radiation Therapy Care Teams: A Mixed-Methods Study Exploring Strategies For Effective Patient Education Delivery, Jie Jane Chen, Anna M Brown, Allison E Garda, Ellen Kim, Sarah A Mcavoy, Michael K Rooney, Kristi L Tonning, Laura E Warren, Daniel W Golden, Jennifer M Croke

Faculty, Staff and Student Publications

Purpose: Patients' understanding of radiation therapy (RT) and data regarding optimal approaches to patient education (PE) within radiation oncology (RO) are limited. We aimed to evaluate PE practices of radiation oncologists and interprofessional RT care team members to inform recommendations for delivering inclusive and accessible PE.

Methods and materials: An anonymous survey was administered to all Radiation Oncology Education Collaborative Study Group members (10/5/22-11/23/22). Respondent demographics, individual practices/preferences, and institutional practices were collected. Qualitative items explored strategies, challenges, and desired resources for PE. Descriptive statistics summarized survey responses. The Fisher exact test compared PE practices by respondent role and PE …

Why Do Patients With Cancer Die?, Adrienne Boire, Katy Burke, Thomas R Cox, Theresa Guise, Mariam Jamal-Hanjani, Rosandra Kaplan, Charles Swanton, Matthew G Vander Heiden, Erik Sahai

Faculty, Staff and Student Publications

Cancer is a major cause of global mortality, both in affluent countries and increasingly in developing nations. Many patients with cancer experience reduced life expectancy and have metastatic disease at the time of death. However, the more precise causes of mortality and patient deterioration before death remain poorly understood. This scarcity of information, particularly the lack of mechanistic insights, presents a challenge for the development of novel treatment strategies to improve the quality of, and potentially extend, life for patients with late-stage cancer. In addition, earlier deployment of existing strategies to prolong quality of life is highly desirable. In this …

Why Do Patients With Cancer Die?, Adrienne Boire, Katy Burke, Thomas R Cox, Theresa Guise, Mariam Jamal-Hanjani, Rosandra Kaplan, Charles Swanton, Matthew G Vander Heiden, Erik Sahai

Faculty, Staff and Student Publications

Cancer is a major cause of global mortality, both in affluent countries and increasingly in developing nations. Many patients with cancer experience reduced life expectancy and have metastatic disease at the time of death. However, the more precise causes of mortality and patient deterioration before death remain poorly understood. This scarcity of information, particularly the lack of mechanistic insights, presents a challenge for the development of novel treatment strategies to improve the quality of, and potentially extend, life for patients with late-stage cancer. In addition, earlier deployment of existing strategies to prolong quality of life is highly desirable. In this …

Impact Of Pretreatment Body Mass Index On The Survival Of Head And Neck Cancer Patients, Zheng Yang, Jobran Mansour, Peng Sun, Peng Wei, Kristina R Dahlstrom, Guojun Li

Faculty, Staff and Student Publications

Background: Differences in pretreatment body mass index (BMI) have been associated with survival in squamous cell carcinoma of head and neck (SCCHN). We examined effects of BMI on survival in SCCHN patients after stratifying patients by tumor human papillomavirus (HPV) status and subsite.

Methods: Totally 2204 SCCHN patients in a prospective study were included in this secondary analysis. Multivariable Cox models were used to evaluate associations between pretreatment BMI and overall survival, disease-specific survival, and disease-free survival.

Results: BMI was significantly higher among patients with HPV-positive tumors than HPV-negative tumors. BMI >25 kg/m2 was associated with improved survival, while BMI …

Markov Models For Clinical Decision-Making In Radiation Oncology: A Systematic Review, Lucas B Mccullum, Aysenur Karagoz, Cem Dede, Raul Garcia, Fatemeh Nosrat, Seyedmohammadhossein Hosseinian, Clifton D Fuller

Faculty, Staff and Student Publications

The intrinsic stochasticity of patients' response to treatment is a major consideration for clinical decision-making in radiation therapy. Markov models are powerful tools to capture this stochasticity and render effective treatment decisions. This paper provides an overview of the Markov models for clinical decision analysis in radiation oncology. A comprehensive literature search was conducted within MEDLINE using PubMed, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Only studies published from 2000 to 2023 were considered. Selected publications were summarized in two categories: (i) studies that compare two (or more) fixed treatment policies using Monte Carlo simulation …

A Qualitative Exploration To Inform An Oral Health Training For Disability Care Workers In Burkina Faso, Ave Põld, Dan Filwendé Kientega, Jocelyne Valérie Garé, Michael Lorenz

Faculty, Staff and Student Publications

AIM: To explore enablers and barriers to the creation of an oral health training for care workers at specialized centres for children with disabilities in Ouagadougou.

DESIGN: This was a formative study informed by the Theoretical Domains Framework using qualitative methods.

METHODS: Qualitative observations and 14 semi-structured interviews were conducted with care workers from six specialized centres for disability.

RESULTS: Carer workers emphasized that a successful oral health training must account for available resources and competencies in each specific centre. Part of the training must be dedicated to oral hygiene targeted for people with disabilities and provide knowledge about risk …

Mapping The Single-Cell Differentiation Landscape Of Osteosarcoma, Danh D Truong, Corey Weistuch, Kevin A Murgas, Prasad Admane, Bridgette L King, Salah-E Lamhamedi-Cherradi, Najat C Daw, Nancy Gordon, Vidya Gopalakrishnan, Richard G Gorlick, Neeta Somaiah, Joseph O Deasy, Antonios G Mikos, Allen Tannenbaum, Joseph Ludwig

Faculty, Staff and Student Publications

Purpose: The genetic intratumoral heterogeneity observed in human osteosarcomas poses challenges for drug development and the study of cell fate, plasticity, and differentiation, which are processes linked to tumor grade, cell metastasis, and survival.

Experimental design: To pinpoint errors in osteosarcoma differentiation, we transcriptionally profiled 31,527 cells from a tissue-engineered model that directs mesenchymal stem cells toward adipogenic and osteoblastic fates. Incorporating preexisting chondrocyte data, we applied trajectory analysis and non-negative matrix factorization to generate the first human mesenchymal differentiation atlas.

Results: This "roadmap" served as a reference to delineate the cellular composition of morphologically complex osteosarcoma tumors and quantify …

Smyd5 Methylation Of Rpl40 Links Ribosomal Output To Gastric Cancer, Juhyung Park, Jibo Wu, Krzysztof J Szkop, Jinho Jeong, Predrag Jovanovic, Natasha M Flores, Ying-Jiun C Chen, Ana Morales Benitez, Emily Zahn, Shumei Song, Jaffer A Ajani, Linghua Wang, Kamini Singh, Ola Larsson, Benjamin A Garcia, Ivan Topisirovic, Or Gozani, Pawel K Mazur

Faculty, Staff and Student Publications

Dysregulated transcription due to disruption in histone lysine methylation dynamics is an established contributor to tumorigenesis1,2. However, whether analogous pathologic epigenetic mechanisms act directly on the ribosome to advance oncogenesis is unclear. Here we find that trimethylation of the core ribosomal protein L40 (rpL40) at lysine 22 (rpL40K22me3) by the lysine methyltransferase SMYD5 regulates mRNA translation output to promote malignant progression of gastric adenocarcinoma (GAC) with lethal peritoneal ascites. A biochemical-proteomics strategy identifies the monoubiquitin fusion protein partner rpL40 (ref. 3) as the principal physiological substrate of SMYD5 across diverse samples. Inhibiting the SMYD5-rpL40K22me3 axis in GAC cell lines reprogrammes …

Proteomics In Orthopedic Research: Recent Studies And Their Translational Implications, George Li, Argyrios Stampas, Yoshihiro Komatsu, Xueqin Gao, Johnny Huard

Faculty, Staff and Student Publications

Proteomics is a growing field that offers insights into various aspects of disease processes and therapy responses. Within the field of orthopedics, there are a variety of diseases that have a poor prognosis due to a lack of targeted curative therapy or disease modifying therapy. Other diseases have been difficult to manage in part due to lack of clinical biomarkers that offer meaningful insight into disease progression or severity. As an emerging technology, proteomics has been increasingly applied in studying bone biology and an assortment of orthopedics related diseases, such as osteoarthritis, osteosarcoma and bone tumors, osteoporosis, traumatic bone injury, …

Meniscus Tears In Elite Athletes: Treatment Considerations, Clinical Outcomes, And Return To Play, Erick M Marigi, Michael R Davies, Robert G Marx, Scott A Rodeo, Riley J Williams

Faculty, Staff and Student Publications

PURPOSE OF REVIEW: Management of meniscal injuries in the elite athlete is a difficult problem secondary to the high demands of athletic competition, the need for a timely return to sport, and the desire to maximize performance over time. The purpose of this review is to provide an up-to-date summary on the current literature and trends regarding the management of meniscus injuries with a special consideration for elite athletes.

RECENT FINDINGS: Historically, partial meniscectomy has been the primary treatment option for meniscus injuries. However, in recent years there has been an increased emphasis on meniscus preservation due to the increased …

A Visualization And Radiation Treatment Plan Quality Scoring Method For Triage In A Population-Based Context, Alexandra O Leone, Abdallah S R Mohamed, Clifton D Fuller, Christine B Peterson, Adam S Garden, Lauren L Mayo, Jay P Reddy, Karen Hoffman, Joshua S Niedzielski, Laurence E Court, Thomas J Whitaker

Faculty, Staff and Student Publications

PURPOSE: Our purpose was to develop a clinically intuitive and easily understandable scoring method using statistical metrics to visually determine the quality of a radiation treatment plan.

METHODS AND MATERIALS: Data from 111 patients with head and neck cancer were used to establish a percentile-based scoring system for treatment plan quality evaluation on both a plan-by-plan and objective-by-objective basis. The percentile scores for each clinical objective and the overall treatment plan score were then visualized using a daisy plot. To validate our scoring method, 6 physicians were recruited to assess 60 plans, each using a scoring table consisting of a …

Case-Case Genome-Wide Analyses Identify Subtype-Informative Variants That Confer Risk For Breast Cancer, Xiaohui Sun, Shiv P Verma, Guochong Jia, Xinjun Wang, Jie Ping, Xiao-Ou Shu, Andriy Derkach, Qiuyin Cai, Xiaolin Liang, Jirong Long, Kenneth Offit, Jung H Oh, Anne S Reiner, Gordon P Watt, Meghan Woods, Yaohua Yang, Christine B Ambrosone, Stefan Ambs, Yu Chen, Patrick Concannon, Montserrat Garcia-Closas, Jian Gu, Christopher A Haiman, Jennifer J Hu, Dezheng Huo, Esther M John, Julia A Knight, Christopher I Li, Charles F Lynch, Lene Mellemkjær, Katherine L Nathanson, Barbara Nemesure, Olufunmilayo I Olopade, Andrew F Olshan, Tuya Pal, Julie R Palmer, Michael F Press, Maureen Sanderson, Dale P Sandler, Melissa A Troester, Wei Zheng, Jonine L Bernstein, Matthew F Buas, Xiang Shu

Faculty, Staff and Student Publications

Breast cancer includes several subtypes with distinct characteristic biological, pathologic, and clinical features. Elucidating subtype-specific genetic etiology could provide insights into the heterogeneity of breast cancer to facilitate the development of improved prevention and treatment approaches. In this study, we conducted pairwise case-case comparisons among five breast cancer subtypes by applying a case-case genome-wide association study (CC-GWAS) approach to summary statistics data of the Breast Cancer Association Consortium. The approach identified 13 statistically significant loci and eight suggestive loci, the majority of which were identified from comparisons between triple-negative breast cancer (TNBC) and luminal A breast cancer. Associations of lead …

Care Fragmentation, Social Determinants Of Health, And Postoperative Mortality In Older Veterans, Carly A Duncan, Michael A Jacobs, Yubo Gao, Michael Mader, Susanne Schmidt, Katherine Hadlandsmyth, Leslie R M Hausmann, Robert A Tessler, Andrea Strayer, Mary Vaughan Sarrazin, Daniel E Hall

Faculty, Staff and Student Publications

Introduction: Veterans Affairs Surgical Quality Improvement Program (VASQIP) benchmarking algorithms helped the Veterans Health Administration (VHA) reduce postoperative mortality. Despite calls to consider social risk factors, these algorithms do not adjust for social determinants of health (SDoH) or account for services fragmented between the VHA and the private sector. This investigation examines how the addition of SDoH change model performance and quantifies associations between SDoH and 30-d postoperative mortality.

Methods: VASQIP (2013-2019) cohort study in patients ≥65 y old with 2-30-d inpatient stays. VASQIP was linked to other VHA and Medicare/Medicaid data. 30-d postoperative mortality was examined using multivariable logistic …

Validating A Scale Of Psychological Flexibility And Inflexibility For Older Adolescents, Caleb Douglas Farley

All Graduate Theses and Dissertations, Fall 2023 to Present

Psychological flexibility (PF) is a skill that is related to various mental health experiences in adults. Higher levels of PF seem related to greater wellbeing. Given increases in mental health problems with youth, measuring PF and its inverse, psychological inflexibility (PI), might be useful for identifying those teenagers at risk for mental health challenges and referring them to appropriate interventions. To date, most measures of PF and PI are only available for adults older than 18, and, while theory suggests PF and PI are important for adolescent mental health, little research has examined the validity of these claims. This multipaper …

Online Multiplayer Video Game Play And College Adjustment, Salina M. Ochoa

All Graduate Theses and Dissertations, Fall 2023 to Present

There are an increasing number of individuals who participate in multiplayer video games and an increase in screen time overall. Due to the increase in online video game play, this study aimed to find possible positive impacts that online multiplayer video games had on freshmen who are adjusting to college, as this is a pivotal point in life. The data were collected at the beginning of the second semester and 99 freshman, 18 years or older, who regularly engaged in online multiplayer video games participated in the study. The study showed four important findings: First, students who receive support from …

Method Development For The Extraction And Analysis Of Per- And Polyfluoroalkyl Substances (Pfas) In Wastewater And Biosolids, Victoria Krull

All Graduate Theses and Dissertations, Fall 2023 to Present

Per and poly-fluorinated alkyl substances (PFAS) are manufactured chemicals that have water and grease repellant properties and do not readily biodegrade. PFAS are present in many consumer products and end up in waste systems and the environment. Studies have shown that PFAS can have adverse health effects on humans and animals.

There are many challenges to processing and analyzing samples containing PFAS including: adsorption of PFAS to equipment, contamination from equipment containing PFAS, and the high sensitivity needed to analyze for PFAS in the parts per trillion detection range. The United States Environmental Protection Agency (EPA) has been developing methods …

Online Act For Caregivers: A Longitudinal Mixed Methods Study, Jacob D. Gossner

All Graduate Theses and Dissertations, Fall 2023 to Present

Family caregivers for people with dementia are a resilient population operating under stressful circumstances that can put them at risk of multiple negative outcomes. Existing interventions may be difficult for family caregivers to access due to time and transportation constraints; an alternative is online, self-guided interventions that caregivers can access from their own homes. The purpose of this dissertation is to evaluate the impact of ACT for Caregivers, a six session online, self-guided program based on the principles of Acceptance and Commitment Therapy. Participants had an average age of 61.93 (SD = 13.69), had been caregiving for an average …

Socially Valued, Ecologically In Decline: Place Attachment Influences Support For Management Actions In A Quaking Aspen Forest Impacted By Recreation, Soil Contamination, And Ungulates, Georgie Corkery

All Graduate Theses and Dissertations, Fall 2023 to Present

Quaking aspen (Populus tremuloides Michx.) spark strong emotional attachments among many people, yet they are ecologically in decline across North America. Aspen landscapes are also popular outdoor recreation destinations. Site-specific strategies are required for both managing for healthy aspen landscapes and enhancing the outdoor recreation experience. Our study investigated a highly-recreated and ecologically declining aspen forest in Summit County, Utah facing population decline. There were two distinct phases of data collection. First, we evaluated the condition of the aspen and identified potential management actions that could improve the condition of the aspen. Second, we surveyed people who visited the site …

Md Simulations Of Collision Effects For A Strongly Coupled Plasma, Jawon Jo

All Graduate Theses and Dissertations, Fall 2023 to Present

Studying strongly coupled plasmas can be effectively accomplished using molecular dynamics (MD) simulations. We have developed an advanced MD simulation code that can analyze plasmas with various coupling parameters. This code employs a spherically symmetric cut-off Coulomb force verified through convergence tests by modulating the cut-off and minimum force ranges. Additionally, it incorporates a new algorithm for optimizing the initial positions of particles at a given temperature. This method maintains the temperature constant and the velocity distribution unchanged. As a result, we eliminate the unphysical initial rises and oscillations in temperature that a random distribution of positions causes. The code …

Shedding Light On Past Ice-Free Intervals In Northwest Greenland: Luminescence Dating Of The Base Of The Camp Century Ice Core, Hawke Woznick

All Graduate Theses and Dissertations, Fall 2023 to Present

The goal of this thesis is to provide greater resolution on the age and character of the subglacial sediment recovered from the base of the Camp Century ice core, northwestern Greenland. Geochemical analysis indicated that the upper sub-ice sediments were geochemically different and experienced greater weathering than the basal unit underlying a one-meter silty ice lens. Analysis of feldspars within the very fine sand fraction indicates they are dominated by potassium feldspar. Sediment was dated using luminescence, which provides an age for the last time sediment was exposed to light. Luminescence analysis returned ages around 420 thousand years old, which …

Relationship Between The Physical Properties And Oil Binding Capacity Of Fats, Melissa Abigail Marsh

All Graduate Theses and Dissertations, Fall 2023 to Present

Fats play a significant role in shaping the characteristics of foods, influencing texture, mouthfeel, appearance, and nutritional attributes. An important property of fats is their ability to entrap liquid oil known as oil binding capacity (OBC). Poor OBC of fats frequently leads to shortened-shelf life of foods caused by quality issues due to unwanted chemical and physical changes. In natural nut butters without additives, low OBC often results in a visual oil layer forming at the surface. In filled chocolates such as truffles, pralines, and peanut butter cups this low OBC can result in unwanted textural and visual changes.

The …

A Scoping Review On The Experiences Of Queer And Trans Students In Stem, Elliot P. Tingey

All Graduate Theses and Dissertations, Fall 2023 to Present

Efforts to increase diversity in STEM (science, technology, engineering, and mathematics) are ongoing, but within these efforts queer and trans individuals are often left out. While initial data does suggest that queer and trans individuals are significantly absent from the STEM workforce, research into the causes of such underrepresentation is scattered. Given the importance of educational experiences in the pursuit of a STEM career, it is likely that these early experiences may play a role. Therefore, the purpose of this paper is to investigate the current research on the experiences of queer and trans students in STEM educational spaces, what …

Assessing The State Of Obesity Care: Quality, Access, Guidelines, And Standards, Louis J Aronne, Deborah B Horn, Aaron S Kelly, Jeffrey I Mechanick, Jonathan Q Purnell, Ximena Ramos-Salas, Assessing The State Of Obesity Care Writing Group

Faculty, Staff and Student Publications

BACKGROUND: An international panel of obesity medicine experts from multiple professional organizations examined patterns of obesity care and current obesity treatment guidelines to identify areas requiring updating in response to emerging science and clinical evidence.

AIMS: The panel focused on multiple medical health and societal issues influencing effective treatment of obesity and identified several unmet needs in the definition, assessment, and care of obesity.

METHODS: The panel was held in Leesburg, Virginia in September 2019.

RESULTS: The panelists recommended addressing these unmet needs in obesity medicine through research, education, evaluation of delivery and payment of care, and updating clinical practice …