Digital Commons Network^™

Assessing Tolerability With The Functional Assessment Of Cancer Therapy Item Gp5: Psychometric Evidence From Libretto-531, A Phase 3 Trial Of Selpercatinib In Medullary Thyroid Cancer, Antoine Regnault, Laurine Bunod, Angely Loubert, Marcia S. Brose, Lisa M. Hess, Patricia Maeda, Yan Lin, Rebecca M. Speck, Adrienne M. Gilligan, Nalin Payakachat

Department of Medical Oncology Faculty Papers

BACKGROUND: This psychometric analysis generated evidence to support the use of the Functional Assessment of Cancer Therapy item GP5 (GP5) as a measure of tolerability and confirms the appropriateness of categorizing "high side-effect burden" using a rating of 3 or 4 (score ranges 0-4) in patients with advanced/metastatic RET-mutant medullary thyroid cancer (MTC).

METHODOLOGY: Blinded, pooled interim data from the safety population (n=290) enrolled in the phase 3 LIBRETTO-531 trial (NCT04211337) were used. Intraclass correlation coefficients (ICC) were calculated for test-retest reliability using data from cycles 1-2 post-baseline. Construct validity was evaluated by examining the correlations of GP5 ratings with …

Increasing Self-Esteem In Early Adolescents, Megan Ostendorf

Dissertations, Theses, and Projects

Self-esteem is how someone views themselves in different aspects of their life. It can fluctuate throughout a person’s life. The literature review in this paper looks at the impact that it makes on their academics, connectedness to school, peer interactions, and how parenting styles play a role in a student's self-esteem. School counselors play a role in helping students to better succeed academically using a variety of interventions using small groups throughout their day. The small group in this paper is used to increase early adolescent students with their self-esteem. The small group takes place once a week for eight …

The Importance Of Adopting A Neurodiversity Affirming Approach: A Training For School Counselors, Emily Bauer

Dissertations, Theses, and Projects

Consisting of a literature review and a training presentation, this project investigates the concerning mental health crisis affecting the autistic community and educates school counselors on how to shift to a neurodiversity-affirming approach to better support student needs. Research shows that autistic individuals subjected to applied behavioral analysis (ABA), social skills training (SST), and other behaviorist treatments experience significantly poorer mental and physical health outcomes as well as lower quality of life, indicating a critical need for change (Aral et al, 2023; Cassidy et al, 2020; Stewart et al, 2023). Supported by modern research, a neurodiversity-affirming approach is a better …

Stigma In Special Education Services With Student Focused Solutions, Deion Heinen

Dissertations, Theses, and Projects

Stigma can impact groups in many different ways. Special education students have endured stigma and the effects of this stigma for decades as proven by years of research. However, student focused solutions have been lacking in the literature and this is critical to give our educators tools to use in order to promote a positive learning environment in their classroom. While in this study, stigma was not proven in students that I currently teach that have IEPs or receive intervention services it was indicated that students rate themselves lower than general education students about how they perceive school. While more …

The Impacts And Interplay Of Adolescent Personal Contexts And Sense Of Belonging To Mathematics On Postsecondary Stem Field Interests And Intentions, Monica J. Weir

Dissertations, Theses, and Projects

This quantitative correlational research sought to examine the relationship between high school students’ sense of belonging to mathematics and their interests and intentions to pursue fields of study and careers in science, technology, engineering, and mathematics (STEM). With a theoretical framework based on the belongingness hypothesis and social cognitive career theory (SCCT), the author explicitly linked the universality of the phenomenon of sense of belonging to individual, contextual, environmental, and experiential factors that influence career-related interest development. A sample of 328 high school students attending one private, Catholic, college preparatory school in the Upper Midwest of the United States responded …

The Impact Of Adverse Childhood Experiences On Juvenile Delinquency, Abigail Holmquist

Dissertations, Theses, and Projects

Abstract

Youth that have been exposed to Adverse Childhood Experiences (ACEs) are at a much higher risk of delinquent acts and involvement in the juvenile legal system. This study includes discussion on two studies of ACEs, conducted by Felitti et al. (2019) and Cronholm et al. (2015), reviews the impact of ACEs on juvenile delinquency in certain demographics, and includes case examples of how I have seen ACEs impact previous clients I had on my caseload. Discussion includes examples of how Social Control Theory and General Strain Theory apply to the relationship of ACEs and juvenile delinquency. Future research recommendations …

Whole Human Pedagogy For Education Abroad, Anna Kelly

Journal of Comparative & International Higher Education

No abstract provided.

Critically Examining The Mobilities Of A Critical Thinking Curriculum In Transnational Higher Education: A Case Study In West Africa, Coomerene Muilerman-Rodrigo

Journal of Comparative & International Higher Education

No abstract provided.

Fans In Ancient Egypt: Iconographic And Contextual Study Of Fans In The Predynastic, Old, And Middle Kingdoms, Nadra Zaki

Theses and Dissertations

A variety of fans existed throughout ancient Egyptian history. They had several forms and were made of different materials. They appear in two- and three-dimensional representations, as well as in texts. They relate to royalty and high officials and also feature in domestic settings, both out- and indoors. Fans were used for creating breeze, and providing shade in real life, and also during the journey to the afterlife, where they combined physical and metaphysical protection. Several names were associated with fans, depending on their functions, both in the secular and sacred world.

Earlier studies have either generally examined fans …

Cytoplasmic And Mitochondrial Calcium Influences Retinal Ganglion Cell Survival To Axon Injury, Sean Mccracken

Arts & Sciences Graduate Student Theses and Dissertations

Retinal Ganglion Cell (RGC) death is the final outcome in optic neuropathies like glaucoma and traumatic optic nerve injury, which represent the leading cause of irreversible blindness worldwide. There are currently no treatments for these diseases targeting RGCs directly, and mechanisms underlying RGC death are unclear. Calcium ion (Ca2+) dysregulation occurs in almost all neurodegenerative conditions, including glaucoma, which has been studied in rodents using a robust injury model of traumatic axon injury, optic nerve crush (ONC). However, the impact of homeostatic Ca2+ regulation in RGCs response to glaucoma or ONC is unknown. Furthermore, while some mechanisms that regulate Ca2+ …

Exploring The Homeostatic Functions And Driving Forces Of Lymphatic Outflow Pathways From The Central Nervous System, Zachary Matthew Papadopoulos

Arts & Sciences Graduate Student Theses and Dissertations

Lymphatic drainage from the central nervous system (CNS) has been noted and described for several hundred years, yet its physiological roles have remained unclear. The fluid homeostasis of the CNS has long stood as an area of scientific interest due to primary disorders including hydrocephalus. However, the early days of neuroimmunology leaned on the lack of lymphatic vasculature in the CNS as a contributing explanation for ‘immune privilege’ in the CNS. As a result, the importance of lymphatics in CNS homeostasis has remained poorly understood and controversial. Following a renaissance in interest in the contribution of lymphatics to CNS homeostasis, …

Perceived Parental Narcissism: The Adult Child's Search Of Romantic Attachment Through Self-Compassion, Deanna A. Bishop

Doctoral Dissertations and Projects

Narcissistic personality disorder is defined by a strong desire for admiration and apathetic responses to others’ emotional needs making bonding in any relationship difficult (American Psychiatric Association, 2022). Healthy bonding within a family environment can be hindered by the lack of empathetic response and agentic behaviors that are characteristic of this personality type (Shaw, 2014). By virtue of innocence and dependency, children are the most vulnerable. The literature illustrates that emotional abuse and neglect, like parental narcissistic abuse, disrupts secure attachment between the parent and the child and can also prevent the child from learning healthy coping mechanisms, such as …

The Commonwealth Of Israel: Overcoming The Doctrinal Divide Of Dispensationalism And Covenantalism Through Understanding Pauline Theology, Luke Newton Schier

Doctoral Dissertations and Projects

Beginning in the early part of the twentieth century, a notable theological schism began to emerge within mainstream Christianity which continues to divide evangelicals in the twenty-first century. Accordingly, adherents from both sides have systemized their theologies and developed labels to define their positions. New labels continue to evolve and change as sub-groups emerge into the conversation. Typically, the labels of dispensationalism and covenantalism are employed to identify the differing views; although covenantalism is also referred to as Reformed theology, replacement theology, or supercessionism. More recently, other labels have emerged such as progressive dispensationalism and progressive covenantalism as theologians strive …

Post-Secondary Education Experiences Of Military-Connected Students: A Phenomenological Study, Craig J. Alia

Doctoral Dissertations and Projects

The purpose of this transcendental phenomenological study was to understand the influence that lifelong stressors had on the lived experiences of adult military-connected students in U.S. post-secondary educational institutions. Military-connected students were defined as the adult children or step-children of military members who attended a minimum of four years in primary school while their parent was on active duty and attended both high school and post-secondary school while their parent(s) were either active duty or retired. The theory guiding this was Pearlin’s stress process, which explains the interaction among and between military-connected students’ (MCS’) stressors, stress mediators, and the resultant …

A Phenomenological Study Of The Experience Of Institutional Betrayal And Help-Seeking Behaviors Of Military Sexual Trauma, Victoria Sheree Tolbert

Doctoral Dissertations and Projects

The purpose of this phenomenological study was to describe military sexual trauma survivors' experiences of military institutional betrayal and help-seeking behaviors. The study was grounded in Jennifer Freyd’s institutional betrayal theory. Using institutional betrayal as a framework was useful in illuminating the effects of institutional betrayal on survivors' perceptions of trust, safety, and decision-making regarding seeking support. The study aimed to understand the complex dynamics between institutional responses, perceived betrayal, and subsequent support-seeking actions among MST survivors within military contexts. Data collection included in-depth interviews, journaling, and cognitive representations with purposively sampled MST survivors. The study used thematic analysis to …

Racial And Ethnic Differences In Outcomes Of Neonates Born At Less Than 30 Weeks' Gestation, 2018-2022, Nansi S. Boghossian, Marco Geraci, Erika M. Edwards, Jeffrey D. Horbar

Faculty Publications

Importance: Previous research has examined outcomes among very preterm newborns by the birthing parent's race and ethnicity, but knowledge about these trends during the COVID-19 pandemic is limited. Objective: To examine trends in outcomes among Black, Hispanic, and Asian preterm newborns compared with White preterm newborns. Design, Setting, and Participants: This cohort study (2018-2022) took place at 774 neonatal intensive care units in the Vermont Oxford Network. Participants were newborns born at 22 to 29 weeks' gestation. Exposure: Race and ethnicity. Main Outcomes and Measures: The primary outcomes were mortality and complications, including respiratory distress syndrome, necrotizing enterocolitis (NEC), early-onset …

A Phenomenological Analysis Of African American Clergy And Congregation Weight Loss Interventions, Linda Fay Carper

Walden Dissertations and Doctoral Studies

This phenomenological study examines the lived experiences of Houston African American clergy regarding their roles and effectiveness in leading weight loss interventions within their faith-based communities. The research addresses the gap in peer-reviewed literature on the impact of Houston-area African American faith-based leadership on the success of weight loss initiatives. Grounded in the Transtheoretical Theory, the study explores clergy perceptions of decisional balance, self-efficacy, and processes of change to inform future health interventions. Ten purposive participants, meeting the inclusion criteria of being clergy leaders in Houston-based congregations with at least 50% African American membership, shared their insights. Data were collected …

Symptoms Of Academic Burnout In Associate Degree Nursing Students, Laura J. Witherspoon

Walden Dissertations and Doctoral Studies

Academic burnout may contribute to high attrition in associate degree nursing (ADN) students because academic burnout affects academic success, causes physical and mental health problems, and decreases self-esteem. Academic burnout may be more prevalent in ADN students because ADN programs are shorter but more intense. The purpose of this study, guided by Maslach’s multidimensional theory of burnout, was to examine the relationship between time in the ADN program and symptoms of academic burnout in nursing student participants and the difference in academic burnout among the four semesters in the ADN students. Maslach’s Burnout Inventory-General survey for students was emailed to …

Early Childhood Teachers’ Perspectives On Implementing Developmentally Appropriate Practice During Online Instruction, Charmaine Bonds

Walden Dissertations and Doctoral Studies

Early childhood teachers had to restructure instruction when the COVID-19 pandemic began, and instruction was completed online. The problem was that early childhood teachers faced challenges using developmentally appropriate practice (DAP) in online instruction during the COVID-19 pandemic. The purpose of this basic qualitative study was to explore early childhood teachers’ perspectives on implementing DAP in online instruction during the COVID-19 pandemic and what they needed to improve their use of quality DAP online instruction. The conceptual framework comprised the DAP and the positive technology development theories. The research questions were used to explore pre-K and kindergarten teachers' perspectives on …

Counselors’ Lived Experiences Supporting Emerging Adults With Psychiatric Disorders Secure Competitive Employment, Cheryl Lakisha Andrews

Walden Dissertations and Doctoral Studies

Transitioning from childhood to adulthood is a challenging life experience, further intensified for individuals with psychiatric disorders. While strong social support serves as a key resilience factor, emerging adults with psychiatric disorders face unique challenges in addition to those encountered by their peers. This population is at heightened risk for adverse outcomes, including difficulty securing employment, a critical milestone for adult independence. Counselors play a pivotal role in supporting these individuals but often report feelings of inadequacy and reluctance to engage with this complex developmental stage. This qualitative hermeneutic phenomenology study explores the lived experiences of counselors who assist emerging …

Staff Education To Increase Confidence And Knowledge Of Workplace Violence In The Outpatient Mental Health Setting, Agnelyne Afugmeyig Ndifor

Walden Dissertations and Doctoral Studies

Mental health care providers are often faced with difficult situations and frequently encounter patients that may exhibit violent or aggressive behavior. Without adequate training and knowledge to manage these situations, there is a risk of harm and a threat to safety for nurses and office staff. Many hospitals and inpatient psychiatric providers provide training and educational modules to educate staff on how to prepare for and manage these situations, but there is not much research about staff confidence in preventing and managing violent or aggressive patients in the outpatient setting. The practice gap that I analyzed in this project was …

Pixel Personalities Ai, Patrick Casey

Theses

The Pixel Personality AI project explores how AI characters can be embedded in augmented reality (AR) environments to foster user interaction and storytelling. By situating AI personas within real-world contexts, the project examines how design principles, storytelling techniques, and user-centric technology can create engaging and intuitive experiences. Through iterative prototyping and design refinement, the project addressed challenges in aesthetic design, interface usability, and AR integration. The resulting low-poly aesthetic and customized visual filters enhance spatial storytelling while maintaining a balance between user focus and environmental immersion. This research highlights the potential of AI-driven narratives to reshape AR experiences, emphasizing user …

Epilepsy Therapies Symposium | Do We Really "Outgrow" Seizures?, Mohammed Ilyas, Dean Naritoku, Alica M Goldman

Faculty, Staff and Students Publications

Initiation and maintenance of antiseizure therapy can be relatively straightforward in most patients. Depending on epilepsy type, patients may be more or less likely to enter remission or a resolution of their epilepsy and the International League Against Epilepsy developed clinically guiding definitions in this regard. The mechanisms by which resolution or remission are achieved are poorly understood which complicates clinical decision making and risk estimate for future seizure relapse. The impetus for the maintenance of medical therapy in a seizure-free patient is also age-dependent. In children, one ought to consider the unknown effects of antiseizure medications on the developing …

Chaotic Waters And Well-Tempered Specters: The Philippnes As Source Of Overseas Labor, Joel David

Kritika Kultura

The precolonial territory that became the Philippines was a participant in maritime Asian politics and warfare that made the Southeast Asian region appear unstable and undefined to newly arrived Western observers. In truth, regional network-building amid labor shortages was a constant concern of the various peoples, with their interdependent arrangements occasionally readjusted because of piratical raids conducted by more capable or determined centers in order to increase their working populations. The Western occupation forces (themselves also subject to limitations in their number) sought to stabilize the communities they subjugated in order to more effectively bankroll their colonial projects, an arrangement …

Zainichi, Mobility, And Jeju Island: On The Representation Of Island In The Novels Of Kim Sok-Pom And Lee Yangji, Myungsim Yang

Kritika Kultura

During the Japanese colonial period (1910-1945), about a quarter of Jeju residents moved to Japan to escape their hardships, as Jeju Island’s industry was inferior to the inland area. In light of this, about 60% of Osaka Zainichi Koreans are deemed from Jeju Island. Against this backdrop, the meaning and symbol of Jeju Island, respectively, are well embodied in novels written by Jeju people who moved to Japan. For them (i.e., Koreans living in Japan), Jeju Island is not only their homeland but also a place where they have painful memories. In addition, Jeju Island means their own identities itself …

Mobility Necropolitics And Harmless Islanders, Jinhyoung Lee

Kritika Kultura

This article critically discusses the wartime mobilization policies implemented by the Japanese Empire on the Korean peninsula during the Pacific War (1941-1945) in terms of mobility necropolitics, a framework that combines mobility studies and Achile Mbembe’s notion of necropolitics. In particular, by examining the lives of the Korean islanders on the imaginary Julan island in Kim Sa-ryang’s novel Bada-ui Norae [Songs of the Sea] (1943-1944) through Giorgio Agamben’s concepts of “harmless” and “desubjectivation,” this paper seeks to excavate a postcolonial moment in colonial Korea. In the “death worlds” of the dead and those who will die on the battlefields, “harmless …

The Island Literature Museum In Korea, Inseop Shin

Kritika Kultura

The literature museum serves as a unique locale that emits the symbolism and cultural essence of literature, enhancing the image of a region. However, in Korea, islands have long been estranged from literature due to insufficient literary infrastructure. Conversely, from a mainland-centric perspective, islands have often been considered as peripheral cultural spaces for poetry and novels. This study focuses on the regional characteristics of islands in Korea and examines the relationship between literature and islands through case studies of Jeju Island’s Literature Museum, Yun Seon-do Literature Museum of Bogildo, and Literary Island Nodo. Each of these island literature museums presents …

Island And Mobility In The Face Of Climate Change: Robert Smithson's Floating Island, Jaeeun Lee

Kritika Kultura

This essay aims to examine the entropic landscape in motion that appears in Floating Island by Robert Smithson, a distinguished earth artist active in the 1970s. Floating Island was a temporary artificial mobile island made with earth, rocks, native trees, and shrubs, towed by a tugboat around Manhattan Island. Smithson attempted to combine his artistic imagination with the theory of science, particularly entropy, a pivotal concept in the second law of thermodynamics while also developing an original idea of his own, namely “dialectics of entropic change” that combined entropy with dialectic. He believed that the dialectic could go beyond entropy …

Where Island Studies Meets Mobility Studies In Literary And Cultural Studies, Maria Luisa Torres Reyes, Luisa Gomez

Kritika Kultura

This special section challenges the conventional view of islands as isolated entities, aiming to portray island life through various lenses like literature, geography, and history. By merging mobility studies with island studies, it explores how movements within and around islands shed light on societal phenomena such as climate change, infrastructure development, migration policies, and trauma borne out of violent historical events. The articles, stemming from a conference on Jeju Island, South Korea, analyze power dynamics, imagination, and re-imagination between mainland and island, center and periphery. They reflect on islands as subjects for social scrutiny and platforms for cultural expression. Through …

The Forest As Sight, The Forest As Narration: Alvin Yapan's Sandali Ng Mga Mata, Glenn Diaz

Kritika Kultura

Fredric Jameson argues that the passage from monopoly to late capitalism or globalization has resulted in a “bewildering new world space” marked by a “weakening of historicity,” if not the outright “suppression of history.” As a result, this dizzying, dehistoricized totality has become unrepresentable. If this foreclosure is premised on the capture of social life by the “interpenetration of government and big business” under late capitalism, this paper argues that the forest, as a historically and narratively illegible space, may offer an escape. Drawing on a Marxist tradition of ecocriticism, in particular Robert Spencer’s work on “forest literature,” and notions …