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Testing The Bullet Dwarf Collision Scenario In The Ngc 1052 Group Through Morphologies And Stellar Populations, Yimeng Tang, Aaron J. Romanowsky, Pieter G. Van Dokkum, T. H. Jarrett, Kevin A. Bundy, Maria Luisa Buzzo, Shany Danieli, Jonah S. Gannon, Michael A. Keim, Seppo Laine, Zili Shen

Faculty Research, Scholarly, and Creative Activity

NGC 1052-DF2 and -DF4 are two ultradiffuse galaxies that have been reported as deficient in dark matter and associated with the same galaxy group. Recent findings suggest that DF2 and DF4 are part of a large linear substructure of dwarf galaxies that could have been formed from a high-velocity head-on encounter of two gas-rich galaxies, known as a “bullet dwarf” collision. Based on new observations from the Hubble Space Telescope, combined with existing imaging from the u band to mid-infrared, we test the bullet dwarf scenario by studying the morphologies and stellar populations of the trail dwarfs. We find no …

Development Of A Streptococcus Mutans Biofilm Model On A Typodont Platform To Investigate Its Dynamics In Orthodontics, Hibah Chughtai

Theses & Dissertations

Introduction: Biofilm formation plays a significant role in dental health, resulting in plaque accumulation, which can lead to caries and oral diseases. Streptococcus mutans (S. mutans) is a key bacterium involved in this process. The goal of this study was to establish a protocol for the development of an S. mutans biofilm on dental typodont teeth to analyze the effects of orthodontic brackets on biofilm formation. Understanding these dynamics is critical for developing strategies to mitigate biofilm accumulation during orthodontic treatment. Methods: S. mutans biofilms were cultivated under three conditions: 96-well tissue culture plates, S. mutans inoculated non-bracketed …

Teaching Video Game As A Leisure Skill To Arab American Children With Autism Spectrum Disorder Using Video Modeling In A School Setting, Lubna Alzayyat

Electronic Theses and Dissertations

Leisure activities are important in assisting individuals with autism spectrum disorder (ASD) to build relationships, learn to behave socially appropriately, and acquire new interests- competences that assist in cultivating positive self-consciousness (Specht et al., 2002; Womack et al., 2011). Statistics indicate that 2.3% of 8-year-old children in the United States are diagnosed with ASD (CDC, 2021). Despite these large numbers and the tremendous benefits of engaging in leisure activities, participation in leisure activities is lower among children with ASD when compared to their typically developing peers (Ratcliff et al., 2018). The situation is worse when compared to children with ASD …

Design, Synthesis, And Characterization Of Multi-Targeting Pyrrolopyrimidine Antifolates As Potential Single Agent Chemotherapeutic Entities, Tejashree Magdum

Electronic Theses and Dissertations

In cancer chemotherapy, the currently marketed antifolates have two major disadvantages: dose-limiting toxicities to normal tissues and susceptibility to drug resistance. These are due to their major transport by the ubiquitously expressed transporter and mutagenesis in enzymes present in cancer cells. This thesis describes an introduction, background, and research progress in antimetabolites-antifolates designed to multi-target (a) one-carbon metabolism and de novo nucleotide synthesis pathway and (b) target overexpressed transporter in cancer cells for selective tumor-targeting.

Cancer cells transport folate through three transporters: ubiquitously expressed reduced folate carrier (RFC), limitedly expressed proton-coupled folate transporter (PCFT), and folate receptors (FRs). The research …

Daily Associations Between Minority Stressors And Dissociation For Sexual Minority Women And Transgender/Nonbinary Individuals: The Role Of Interpersonal Trauma, Kriti Behari

Theses - ALL

Sexual minority women (SMW), transgender, and/or gender-diverse (TGD) individuals experience interpersonal traumatic stressors (e.g., childhood abuse, sexual violence) at higher rates than their cisgender, heterosexual counterparts. This population also experiences ongoing stressors related to their minoritized sexual and gender identities (e.g., stigma, discrimination). Dissociation has been positively associated with trauma exposure-related factors (e.g., trauma type, chronicity, and severity) as well as identity-related stressors (e.g., stigma, discrimination) for sexual and gender minority people. Some research suggests that experiencing dissociation in response to traumatic stressors can result in individuals responding to non-traumatic chronic stressors with dissociation. However, no study has yet examined …

Tanzania Petroleum Development Corporation (Tpdc) And Its Role In Self-Reliance And Sustainability, Ladislaus Norbeth Tumbu

Theses - ALL

Tanzania possesses significant natural gas reserves, currently estimated at 57.54 trillion cubic feet, with the potential for further discoveries. This thesis examines the socio-economic impacts of Tanzania’s substantial natural gas reserves, focusing specifically on the Tanzania Petroleum Development Corporation (TPDC) and its engagement with the local communities in Mtwara and Lindi. TPDC is the national oil company and owner of all licenses for energy development in the country, wholly owned by the government of Tanzania with all its shares held by the Treasury Registrar. Through comprehensive literature review and field visits to production sites, the study examines TPDC’s management of …

Design And Investigation Of Small Molecule Drugs For Potential Treatment Of Cns Disorders, Flaviviral Infections, And Cancers, Viktoriya Mashinson

Theses & Dissertations

Chapter 1 discusses the development of antagonists against the dopamine 4 receptor (D4R) that is expressed in the motor, associative, and limbic subdivisions of the basal ganglia network and is involved in Parkinson’s disease (PD). Levodopa is the firstline drug for the management of PD symptoms but its long-term use often leads to development of levodopa-induced dyskinesia (LID). D4R antagonists have been shown to decrease the abnormal involuntary movement scores in mouse models of LID. Chapter 1 outlines the development and optimization of selective D4R antagonists for potential treatment of LID. During the investigation of our D4R antagonists we discovered …

Mean From Median Estimation In Longitudinal Meta-Analysis Of Quality Of Life In Radiation Oncology Patients, Harlan R. Sayles

Theses & Dissertations

Meta-analysis of longitudinal data, where some of the studies report results with means and standard errors while others use medians and ranges, is a complex analytical problem with several challenges which must be overcome. Existing methods for estimating means from medians and either ranges, interquartile ranges, or both have not previously been evaluated in a longitudinal setting. In this work, a simulation study was used to estimate mean bias, between studies variance bias, and coverage of confidence intervals in a longitudinal setting. A second simulation study estimated the variance of meta-analysis results from a given set of studies that may …

Biobehavioral Correlates Of Multidimensional Fatigue In Men With Prostate Cancer, Kristin Dickinson

Theses & Dissertations

The purpose of this thesis project was to 1) examine trajectories of multidimensional cancer-related fatigue (CRF) in men with prostate cancer during and after radiation treatment completion, and 2) identify biobehavioral correlates (demographic, clinical, co-occurring symptoms, and biologic [inflammatory cytokines]) for the different CRF dimensions.

Data for this secondary analysis were obtained from a descriptive, longitudinal IRB-approved study investigating men with non-metastatic prostate cancer receiving radiation therapy (RT). Data were obtained from 68 participant medical records, self-report questionnaires, and blood samples. Data were collected at: baseline (T1), completion of RT (T2), 6 months (T3) and 2 years (T4) after completion …

Prospective, Crossover, Comparative Study Of Two Methods Of Chlorhexidine Bathing, Richard J. Hankins

Theses & Dissertations

Bathing intensive care unit (ICU) patients with chlorhexidine gluconate (CHG) decreases hospital acquired infections (HAIs). The optimal method of CHG bathing remains undefined. Prospective cluster crossover study comparing CHG daily bathing with 2% CHG impregnated cloths versus 4% CHG solution. In phase 1, from January 2020 through March 2020, one ICU utilized 2% cloths, while the other ICU utilized 4% solution. After an interruption caused by the COVID-19 pandemic, in phase 2, from July 2020 through September 2020, the unit CHG bathing assignments were reversed. Swabs were performed three times per week from patients’ arms and legs to measure skin …

Data For: Examining The Impacts Of Demographics, Individual Experiences, And Perceptions On Range Anxiety And Electric Vehicle Road Trips, Joshua Ward, Patrick A. Singleton, Antje Graul, Zane Regan

Browse all Datasets

Electric Vehicle Road Trip Study: These data contain anonymized responses to a survey designed to investigate the experiences, perceptions, barriers, and opportunities identified by electric vehicle (EV) drivers regarding road trips to recreational areas (like national parks) and for recreational activities.

Assembly Of Ppsu-Oligomers, Mariam Nesterov

Student Theses and Dissertations

The development of nanostructures for delivering multiple proteins to targeted antibodies has become a promising avenue in biotechnology, driven by advancements in synthetic polymers like poly(propylene sulfone), PPSU. However, the PPSU polymer faces a major limitation - its high insolubility. To address this challenge, this study investigates whether PPSU oligomers can enhance both the solubility and stability of lysozyme, a model protein that is cost-effective and widely accessible. Using dimer, trimer, tetramer, and hexamer configurations, we analyzed the interactions between PPSU oligomer and lysozyme under varying conditions. Our results show that the dimer and trimer are water soluble (no aggregate …

Addressing Over-The-Counter Proton Pump Inhibitor Overuse: Strategies For Pharmacists To Enhance Patient Care, Brenna Hissong, Giang Nguyen, Alexander Defranco, Layla Dials, Jordyn Linfield, Haley Brown, Joshua Honaker, Samantha Mccord, Alaina Kortokrax

Pharmacy and Wellness Review

Proton pump inhibitors (PPIs) are among the most commonly prescribed and widely used medications for the treatment of gastrointestinal (GI) disorders. PPIs irreversibly inhibit the H+/K+-ATPase enzyme, effectively reducing gastric acid secretion and providing sustained relief for acid-related conditions. With the approval of over-the-counter (OTC) PPIs, the number of individuals taking these medications for prolonged periods of time without routine monitoring for the appropriateness of therapy has increased. The overuse of OTC PPIs can be attributed to a number of factors, including ease of access, perceived safety, inadequate understanding of OTC PPI treatment intervals, and a lack of awareness regarding …

Implementing A Transition Plan For Adolescents With Adhd Transitioning To Adult Care, Emily Anderson

Seton Hall University Dissertations and Theses (ETDs)

Background: Annually in the United States approximately 750,000 children with special health care needs transition from pediatric to adult health care. Attention deficit hyperactivity disorder (ADHD) is one of the most prevalent neurodevelopmental disorders and nearly two thirds of children who have symptoms of ADHD in childhood have symptoms that persist to adulthood (Inman et al., 2017). The Child Development Center at a large medical center in northern New Jersey, prior to this project, did not have a transition process or procedure in place to aid providers to successfully prepare adolescent patients with ADHD for transition to adult care. Transition …

Copyright And Research In Latin America: Law, Courts, And Perceptions, Mariana G. Valente, Alice P. Lana, André P. Houang

Joint PIJIP/TLS Research Paper Series

Research on the intersection of copyright law, research activities, and innovation in Latin America reveals significant deficiencies in the legal framework and public discourse surrounding copyright limitations and exceptions (L&Es) for research purposes. The problem is more visible with modern data assembling and analyzing techniques, such as through artificial intelligence (AI) systems. This study highlights the scarcity of explicit provisions for research-related exceptions in the region by examining copyright legislation, case law, and stakeholder perspectives in six Latin American countries. Despite indications that judicial interpretation is expanding the scope of L&Es, particularly in Brazil, awareness of legal nuances remains low …

How Does Health Professions Student Engagement Differ Across Campuses In A Synchronous Multi-Campus Learning Environment?, Satera Nelson

Theses & Dissertations

Student engagement is positively associated with academic achievement, student satisfaction, and retention. In synchronous multi-campus learning, students learn simultaneously while physically located at several campuses throughout the state. This educational model is one way to address the rural health care shortage, as many students who study at rural campuses tend to stay in rural areas to practice. Student engagement is crucial to ensuring that students at rural campuses have a comparable learning experience and to help those students feel like they are a valued part of the class. The purpose of this study was to evaluate health professions student and …

Sparkled: Social Programming In Kids Affects Risk Of Latent Endothelial Disease, Rebecca Drakowski

Theses & Dissertations

Background: Social Health Programming (SHP) is a holistic intervention that can empower communities to address modifiable risk factors for poor cardiovascular health, including suboptimal nutrition or psychosocial stressors. SHP participation has been shown to increase dietary intake of fruits and vegetables, decrease perceived stress, and improve cardiovascular endurance. However, it is unknown how SHP participation during adolescence affects carotenoid serum levels, hair cortisol concentrations (biological marker of chronic stress), or vascular reactivity index (VRI; measure of subclinical cardiovascular health).

Methods: Adolescent girls and young adult women (12–29-year-old) were enrolled in this observational cohort study. Serum, hair, and saliva samples were …

Influence Of Antibody–Drug Conjugate Cleavability, Drug-To-Antibody Ratio, And Free Payload Concentration On Systemic Toxicities: A Systematic Review And Meta-Analysis, Shou Ching Tang, Carrie Wynn, Tran Le, Martin Mccandless, Yunxi Zhang, Ritesh Patel, Nita Maihle, William Hillegass

School of Medicine Faculty Publications

While in theory antibody drug conjugates (ADCs) deliver high-dose chemotherapy directly to target cells, numerous side effects are observed in clinical practice. We sought to determine the effect of linker design (cleavable versus non-cleavable), drug-to-antibody ratio (DAR), and free payload concentration on systemic toxicity. Two systematic reviews were performed via PubMed search of clinical trials published between January 1998—July 2022. Eligible studies: (1) clinical trial for cancer therapy in adults, (2) ≥ 1 study arm included a single-agent ADC, (3) ADC used was commercially available/FDA-approved. Data was extracted and pooled using generalized linear mixed effects logistic models. 40 clinical trials …

Intrinsic Gas-Phase Behavior Of Uranium Species: A Comprehensive Reactivity Study Of [O=U≡Ch]+ And [Uh]+, Justin Terhorst

Electronic Theses and Dissertations

The intrinsic chemistry of actinide elements, particularly uranium, remains a key challenge in understanding f-block reactivity due to the complexity introduced by solvent interactions, counter-ions, and complex equilibria in the condensed phase. In this dissertation, a systematic gas-phase study utilizing preparative tandem ion-trap mass spectrometry (PTMSⁿ) is presented, focusing on the reactivity of uranium-centered species, specifically [OUCH]⁺, an oxy uranium methylidyne species, and [UH]⁺ ions. By stripping away solvent effects and isolating the ions, PTMSⁿ provides a powerful platform to probe the fundamental chemical behavior of uranium species in their intrinsic state.

The …

Synthetic Studies On Ship Activators And New Oxidative Methods Utilizing Ddq And Hypervalent Iodine Catalysts, Christos Nixarlidis

Dissertations - ALL

One important cell signaling pathway is the PI3K pathway because it influences many key cellular functions such as proliferation and apoptosis. Among the enzymes that are involved in this pathway, the SH2-containing inositol-5’-phosphatase (SHIP) plays an important role by maintaining the balance of PI(3,4,5)P3 and PI(3,4)P2. SHIP activation promotes a higher rate of hydrolysis of PI(3,4,5)P3 and thus reduces the downstream activation of AKT, which influences many cell processes. Activation of SHIP using small molecules may be useful for certain diseases such as inflammatory disorders and some types of cancer. The synthesis and evaluation of a new class of sulfonamide …

Noise-Enhanced Network Science, Reyhaneh Abdolazimi

Dissertations - ALL

Graphs are a versatile and powerful data structure used to model complex relationships in diverse domains such as social networks, biological systems, and transportation networks. In graphs, entities are represented by nodes, and interactions or relationships between them are represented by edges. For example, in the World Wide Web, web pages are considered vertices, and if there is a link from one page to another page on the web, there will be a directed edge between those pages in its graph data structure. These structures allow us to analyze and solve important problems like community detection (identifying closely related clusters …

Modulating Liquid-Liquid Phase Separation Of Intrinsically Disordered Proteins Through Lipidation, Zhe Zhang

Dissertations - ALL

Liquid-liquid phase separation (LLPS) is a fascinating biological phenomenon that enables cells to form membraneless organelles, creating specialized compartments for orchestrating complex biochemical reactions. While significant progress has been made in deciphering the sequence determinants underlying phase separation, precisely modulating these features remains a challenge. Inspired by biology, post-translational modifications (PTMs) offer a promising approach to modulate the protein condensates formation and their properties in real-time, without altering the sequences. Despite the identification of over 300 types of PTMs, most research has predominantly focused on charge-altering modifications. The effects of non-charged PTMs, such as lipidation, on LLPS remain poorly understood. …

Power-Conscious Legal Work: Building A Roadmap For Rural Access To Justice Through Trust, Accountability, & Trauma-Informed Practices, Cayley Balser, Antonio M. Coronado

Alaska Law Review

The importance of trauma-informed practices has never been greater. In the United States, most of the population has experienced at least one traumatic event in their life. Experiencing a traumatic event may have long-lasting impacts on physical health, including disruption to all major system functioning. Mental health impacts may include behavior changes, memory challenges, inability to complete routine tasks, difficulty with interpersonal relationships, and other symptoms associated with Post Traumatic Stress Disorder. Extant literature examines the association between past trauma experiences and later interactions with the civil justice system, including litigant conceptualizations of legal system engagement as a traumatic event …

Seizing Welfare From The Bankrupt, Michael D. Sousa

University of Cincinnati Law Review

The earned income tax credit (EITC) is currently the largest means-tested antipoverty program in the United States that assists low-income working families surviving along the edges of poverty. A central component of the national welfare system, the EITC has lifted millions of families with children out of poverty and has produced myriad benefits for their everyday lives. But most of the poor and near-poor endure in the low-wage labor market and often lead turbulent financial lives, plagued by precarious employment along with deleterious material and psychological constraints in budgeting for daily expenses. For the segment of these families also burdened …

To Define And Protect The Best Interest Of The Child, Nadia Abdulbaki

Honors Program Theses and Research Projects

Domestic violence is a prevalent crisis that has detrimentally impacted the well-being of individuals on a personal, communal, and global scope. Domestic violence is characterized as generational violence where exposed children have a heightened risk of becoming the perpetrators of or being perpetrated by violence. Using the Texas Family Code and supporting scholarly documents, the adverse effects exposure to violence has on children, and the current law regarding child custody in parental separation for cases of domestic violence was investigated. Research determined that continued exposure to violence is influenced by the judicial ruling of full or partial child custody to …

Evaluating The Effectiveness Of Benguet Pine (Pinus Kesiya) Xylem For Deep Well Water Filtration, Allen Conner C. Hizon, Robert Zachary M. Santos, Juan Jose B. Lacson, Jefferson Danilo G. Villarin, Juan Carlo T. Gumangan

Sinaya: A Philippine Journal for Senior High School Teachers and Students

Even today, many rural and remote communities still do not have access to safe drinking water, which is a basic right of every human. To address this problem, the effectiveness of the Benguet pine tree (Pinus kesiya) xylem as a sustainable water filtration method for well water was investigated. The physical and chemical properties of the filtered and unfiltered deep well water were tested: the total dissolved solids (TDS) and the electrical conductivity using a 5-in-1 electronic water quality tester and the pH level using pH strips. On the other hand, the microbiological metrics, such as heterotrophic plate …

A Narrative Inquiry On The Parent-Child Relationships Of Higher-Weight Late Adolescents, Hien Anh Miguel G. Dang, David Rigel Dela Cruz Panes, Belle Beatriex' M. Alemania

Sinaya: A Philippine Journal for Senior High School Teachers and Students

Late adolescence is a crucial developmental phase marked by significant psychological and emotional changes as individuals transition from childhood to adulthood. However, the specific impact of parental influence on the body image of higher-weight adolescents remains underexplored. This narrative study aimed to examine the parent-child relationship of higher-weight Filipino adolescents, delving more into how parental opinions influence late adolescents' well-being and perception of their bodies. To answer the objective, a qualitative method through semi-structured interview was employed where four participants were chosen by conducting purposive and snowball sampling. Various themes emerged, mainly struggles with body weight acceptance and insecurities, internalizing …

Transgenerational Legislative Awareness Issues In Children's Food, Yi Seul Kim

Duke Environmental Law & Policy Forum

No abstract provided.

Re-Indigenizing And Collaboratively Tending Urban Greenspaces, Divinity Nnenne Adewale

University Honors Theses

This work details the active process of land tending with the intention of re-Indigenization in the Pacific Northwest at several Portland sites; The Native American Student Community Center, PSU Oak Savanna, and the Ridgefield National Wildlife Refuge. Land tending is an intuitive process, one rooted in love and respect for life of all forms as well as becoming the perpetual student; land tending is not a skill to be mastered, only practiced. Unlike environmental management, tending cannot be done separate from the earth, in a classroom or otherwise. Connections are what tending is built on top of: the foundation; effort …

Indigenous Metal: Rage, Rejects, And The Reconstruction Of Culture, Louis W. Asbury

Master's Theses

Metal music’s latest frontier is Indigenous metal, combining explorations of Indigenous identity with the heavy and aggressive stylings of the music genre. To explore this new subgenre, this study asks to what extent can metal music be used as a political tool and what are some of the broader effects of metal bands working to better their communities. This thesis utilizes case studies of two notable Indigenous metal scenes, the Rez metal scene in the Navajo Nation and the Māori metal scene in Aotearoa. By collecting data from these scenes, including lyrics, videos, interviews, and audience interactions, this thesis thoroughly …