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Articles 117781 - 117810 of 1826622
Full-Text Articles in Entire DC Network
How The Wwf Came To Mongolia, Hartmut Jungius, Chimed-Ochir Bazarsad, Hans Dieter Knapp
How The Wwf Came To Mongolia, Hartmut Jungius, Chimed-Ochir Bazarsad, Hans Dieter Knapp
Erforschung biologischer Ressourcen der Mongolei / Exploration into the Biological Resources of Mongolia, ISSN 0440-1298
Three leading actors and eyewitnesses describe how WWF came to Mongolia in 1992 and supported the development and implementation of a comprehensive protected area system.
A New Species Of Pherbellia From Mongolia (Diptera, Sciomyzidae), Jonas Mortelmans
A New Species Of Pherbellia From Mongolia (Diptera, Sciomyzidae), Jonas Mortelmans
Erforschung biologischer Ressourcen der Mongolei / Exploration into the Biological Resources of Mongolia, ISSN 0440-1298
Pherbellia debreei spec. nov. is described based on one male. The new species is described from Mongolia. High-resolution pictures of male habitus are provided, together with details of the male terminalia to facilitate identification of the new species.
Ergänzungen Zur Vorläufigen Checkliste Der Laufkäfer (Coleoptera: Carabidae) Der Mongolei, 4: Beitrag Zur Carabidenfauna Der Mongolei = Supplements To The Preliminary Checklist Of The Ground Beetles (Coleoptera: Carabidae) Of Mongolia, 4: Contribution To The Ground Beetle Fauna Of Mongolia, Peer Schnitter, Davaa Lkhagvasuren
Ergänzungen Zur Vorläufigen Checkliste Der Laufkäfer (Coleoptera: Carabidae) Der Mongolei, 4: Beitrag Zur Carabidenfauna Der Mongolei = Supplements To The Preliminary Checklist Of The Ground Beetles (Coleoptera: Carabidae) Of Mongolia, 4: Contribution To The Ground Beetle Fauna Of Mongolia, Peer Schnitter, Davaa Lkhagvasuren
Erforschung biologischer Ressourcen der Mongolei / Exploration into the Biological Resources of Mongolia, ISSN 0440-1298
Until now 451 species and subspecies of ground beetles were reported for Mongolia (SCHNITTER 2016). In the last years were found 15 species new for the fauna: Asaphidion cupreum ANDREWES, 1925 ; Bembidion (Melomalus) altaicum GEBLER, 1833; Bembidion (Trichoplataphus) deplanatum A. MORAWITZ, 1862; Bembidion (Plataphus) fellmanni (MANNERHEIM, 1823); Bembidion (Testediolum) kokandicum SOLSKY, 1874; Bembidion (Trichoplataphus) parconaturaviva TOLEDANO, 2010; Bembidion (Peryphus) poppii eugenes JEDLIČKA, 1933; Bembidion (Terminophanes) sjoelanderi JEDLIČKA, 1965; Bembidion (Eurytrachelus) vitiosum GEMMINGER & HAROLD, 1868; Dyschirius (Dyschiriodes) longicollis MOTSCHULSKY, 1844; Platidiolus …
Genetic Insights Into The Diversity Of Mongolian Oedipodinae: A Multi-Gene Approach, Lara-Sophie Dey, Davaa Lkhagvasuren, Martin Husemann
Genetic Insights Into The Diversity Of Mongolian Oedipodinae: A Multi-Gene Approach, Lara-Sophie Dey, Davaa Lkhagvasuren, Martin Husemann
Erforschung biologischer Ressourcen der Mongolei / Exploration into the Biological Resources of Mongolia, ISSN 0440-1298
This study presents an examination of the genetic diversity of Oedipodinae, a subfamily of grasshoppers, with focus on their distribution and variation in Mongolia. Utilizing a multi-gene approach, we analyze genetic data from various Oedipodinae species from Mongolia, aiming to improve our understanding of their phylogenetic relationships. This research not only enhances our knowledge of Oedipodinae diversity in Mongolia, but also underscores the importance of genetic studies in unraveling the complexities of sequence and potentially species evolution. Despite the implementation of a multi-gene approach in this study, the results indicate a lack of clear phylogenetic differentiation within the tribes Sphingonotini …
Seasonal Variations In Vocal Frequency And Volume Of Mongolian Marmots (Marmota Sibirica Radde, 1862): Insights From Cooperative Breeding In Songinokhairkhan Mountain, Sainzorigt Munkh-Orgil, Nyamsuren Batsaikhan, Gerelt Gan-Ochir, Amarsanaa Zolzaya, Altangerel Tsogtsaikhan Dursahinhan
Seasonal Variations In Vocal Frequency And Volume Of Mongolian Marmots (Marmota Sibirica Radde, 1862): Insights From Cooperative Breeding In Songinokhairkhan Mountain, Sainzorigt Munkh-Orgil, Nyamsuren Batsaikhan, Gerelt Gan-Ochir, Amarsanaa Zolzaya, Altangerel Tsogtsaikhan Dursahinhan
Erforschung biologischer Ressourcen der Mongolei / Exploration into the Biological Resources of Mongolia, ISSN 0440-1298
In the Songinokhairkhan Mountain region of Mongolia, we examined the vocal patterns of Mongolian marmots, Marmota sibirica (RADDE, 1862), across two seasons. The study aimed to understand how cooperative breeding, a system where certain individual marmots assist others in reproduction, influences their vocalization. Our acoustic data revealed differences in vocal frequency and volume between the post-mating period in April and May, and pup emergence time in July. Specifically, marmots vocalized more frequently during early mornings, with variations observed in call patterns and volume between the two study periods. These findings provide crucial insights into how marmots adjust their communication strategies …
New Record Of Gvosdevilepis Fragmentata (Gvosdev, 1948) (Cestoda: Hymenolepidinae) From Lepus Tolai (Lagomorpha: Leporidae) In Mongolia, Allison R. Hearty, Nyamsuren Batsaikhan, Gábor R. Rácz, Scott L. Gardner
New Record Of Gvosdevilepis Fragmentata (Gvosdev, 1948) (Cestoda: Hymenolepidinae) From Lepus Tolai (Lagomorpha: Leporidae) In Mongolia, Allison R. Hearty, Nyamsuren Batsaikhan, Gábor R. Rácz, Scott L. Gardner
Erforschung biologischer Ressourcen der Mongolei / Exploration into the Biological Resources of Mongolia, ISSN 0440-1298
Three individuals of Lepus tolai (Lagomorpha: Leporidae) were collected from southern Mongolia between 2009 and 2010 and examined for endoparasites. Gvosdevilepis fragmentata (GVOSDEV, 1948) (Cestoda: Hymenolepidinae) was identified from one male hare. Gvosdevilepis fragmentata is a known parasite of Leporidae in Europe and Asia. This is the first record of Gvosdevilepis fragmentata from Mongolia.
Die Fledermäuse Der Mongolei: Ein Aktueller Überblick, Dietrich Dolch, Michael Stubbe, K. Thiele, B. Gärtner, Nyamsuren Batsaikhan, J. Ariunbold, B. Wuntke, I. Bolorchimeg, Davaa Lkhagvasuren, I. Scheffler, D. Munkhnast, N. Nandin-Erdene, D. Steinhauser, Annegret Stubbe
Die Fledermäuse Der Mongolei: Ein Aktueller Überblick, Dietrich Dolch, Michael Stubbe, K. Thiele, B. Gärtner, Nyamsuren Batsaikhan, J. Ariunbold, B. Wuntke, I. Bolorchimeg, Davaa Lkhagvasuren, I. Scheffler, D. Munkhnast, N. Nandin-Erdene, D. Steinhauser, Annegret Stubbe
Erforschung biologischer Ressourcen der Mongolei / Exploration into the Biological Resources of Mongolia, ISSN 0440-1298
This paper presents the 20 bat species currently known in Mongolia. The majority of the data were collected during eight Mongolian/German field excursions of the working group "Chiroptera Mongolia” over a period of 25 years and by the results of the Mongolian-German Biological Expeditions between 1964 and 2024. Also further records made by the authors during other tours through Mongolia were considered. This publication expands and updates a previous publication on this topic published 18 years ago (DOLCH et al. 2007).
More than 2150 animals from over 150 capture and discovery sites were included. The captured animals were examined based …
Die Fledermausfauna In Den Nördlichen Regionen Der Mongolei (Taiga, Waldsteppe Und Galeriewälder): Eine Auswertung Von Untersuchungen Zwischen 2002 Und 2024, Beatrix Wuntke, Klaus Thiele, Dietrich Dolch
Die Fledermausfauna In Den Nördlichen Regionen Der Mongolei (Taiga, Waldsteppe Und Galeriewälder): Eine Auswertung Von Untersuchungen Zwischen 2002 Und 2024, Beatrix Wuntke, Klaus Thiele, Dietrich Dolch
Erforschung biologischer Ressourcen der Mongolei / Exploration into the Biological Resources of Mongolia, ISSN 0440-1298
The bat fauna in northern Mongolia was studied on several expeditions between 2002 and 2024 using mist netting and bat recording devices. This paper presents the results of these expeditions for three habitat types (taiga, forest steppe and gallery forest). The species range was highest in the gallery forests and lowest in the forest steppe. It included several species of the genus Myotis as well as representatives of the genera Eptesicus, Vespertilio and Plecotus. The most frequently captured species were Myotis davidii, Eptesicus nilssonii and Plecotus ognevi. The genus Myotis also dominated the recordings, although species …
Ephemeral Seagrass Meadow Assessment To Improve Understanding Of Resilience Of Ephemeral Seagrasses On Kwinana Shelf For Environmental Impact Assessment And Management, Kathryn Mcmahon, Nicole Said, Chanelle Webster, H. Williams, Simone Strydom
Ephemeral Seagrass Meadow Assessment To Improve Understanding Of Resilience Of Ephemeral Seagrasses On Kwinana Shelf For Environmental Impact Assessment And Management, Kathryn Mcmahon, Nicole Said, Chanelle Webster, H. Williams, Simone Strydom
Research outputs 2022 to 2026
Executive Summary:
• This study was conducted to generate knowledge to inform the environmental impact and prediction process for seagrass species that form ephemeral meadows in Cockburn Sound and Owen Anchorage.
• Local light thresholds for the opportunistic species, Syringodium isoetifolium were generated at summer and winter temperatures, with higher light requirements in summer compared to winter, and compared to larger, more slow-growing persistent species such as Posidonia sinuosa. The half-saturating irradiance (Ik) was 115 μmol m-2 s-1 at 23 °C.
• Based on the dynamics at three sites from December 2023 to April 2024, Halophila ovalis forms ephemeral meadows …
Can Llm Agents Maintain A Persona In Discourse?, Pranav Bhandari, Nicolas Fay, Michael Wise, Amitava Datta, Stephanie Meek, Usman Naseem, Mehwish Nasim
Can Llm Agents Maintain A Persona In Discourse?, Pranav Bhandari, Nicolas Fay, Michael Wise, Amitava Datta, Stephanie Meek, Usman Naseem, Mehwish Nasim
Research outputs 2022 to 2026
Large Language Models (LLMs) are widely used as conversational agents, exploiting their capabilities in various sectors such as education, law, medicine, and more. However, LLMs are often subjected to context-shifting behaviour, resulting in a lack of consistent and interpretable personality-aligned interactions. Adherence to psychological traits lacks com- prehensive analysis, especially in the case of dyadic (pairwise) conversations. We examine this challenge from two viewpoints, initially using two conversation agents to generate a dis- course on a certain topic with an assigned personality from the OCEAN framework (Open- ness, Conscientiousness, Extraversion, Agree- ableness, and Neuroticism) as High/Low for each trait. This …
Temporal Network Analysis Of Comorbidities Among People With Hiv In South Carolina, Yunqing Ma, Matthew Lohman Ph.D., Monique J. Brown Ph.D., Mph, Yichen Li, Xiaoming Li Ph.D., Bankole Olatosi Ph.D., Jiajia Zhang Ph.D.
Temporal Network Analysis Of Comorbidities Among People With Hiv In South Carolina, Yunqing Ma, Matthew Lohman Ph.D., Monique J. Brown Ph.D., Mph, Yichen Li, Xiaoming Li Ph.D., Bankole Olatosi Ph.D., Jiajia Zhang Ph.D.
Faculty Publications
Introduction: People with HIV experience a high rate of comorbidities that can complicate their health outcomes. Understanding the prevalence, interrelationships and temporal development of these comorbidities is crucial for improving health management and quality of life for people with HIV. Methods: We used a population-based cohort extracted from statewide electronic health record (EHR) data in South Carolina (SC), including 18 649 people with HIV who survived at least 1 year after HIV diagnosis between January 1, 2005, and December 31, 2020. Comorbidities and organ systems were classified using ICD-10 codes. Network analysis was performed to assess the closeness centrality among …
Comparing The Swallowing Dynamics Of Mandibular Implant Overdentures Retained With Different Attachment Systems: A Crossover Study, Nermeen Elsayed Mohamed Abdallah, Noha Hosny Elshaheed, Abdullah Mohammed Ibrahim Salem
Comparing The Swallowing Dynamics Of Mandibular Implant Overdentures Retained With Different Attachment Systems: A Crossover Study, Nermeen Elsayed Mohamed Abdallah, Noha Hosny Elshaheed, Abdullah Mohammed Ibrahim Salem
Mansoura Journal of Dentistry
Objective This study's objective was to compare the swallowing dynamics for mandibular implant-retained overdentures with different attachment systems Materials and methods for this crossover study, 15 healthy patients were chosen from the outpatient clinic, Department of Removable Prosthodontics, Faculty of Dentistry. The patients already had 2 implants in the canine regions. New mandibular implant-retained overdentures with three different attachment systems (locator, ball, and bar) were constructed. Swallowing evaluation was done after 3 months of each implant overdenture insertion. Swallowing dynamics were evaluated by using the Test of Mastication and Swallowing Solids (TOMASS) and the Timed Water Swallow Test (TWST). ANOVA …
Effect Of Naringenin Cisplatin Combination On Apoptosis Of Human Tongue Squamous Cell Carcinoma Cell Line, Nahed Atef, Nancy Hussein, Mohamed Grawesh, Mohamed Anees
Effect Of Naringenin Cisplatin Combination On Apoptosis Of Human Tongue Squamous Cell Carcinoma Cell Line, Nahed Atef, Nancy Hussein, Mohamed Grawesh, Mohamed Anees
Mansoura Journal of Dentistry
Aim and Objectives: This research was aimed to evaluate the efficacy of a combination treatment comprising the natural compound Naringenin (NAR) and the chemotherapeutic agent Cisplatin (CP) regarding the reduction of cell viability and the induction of apoptosis in human TSCC (HNO-97) and normal oral epithelial cell (NOEC) lines. Material and Methods: The cytotoxicity and IC50 of NAR, CP, and their combinations were evaluated using the MTT assay. The expression levels of the apoptotic marker genes p53 and caspase-3 were assessed using RT-PCR. Western blot analysis was carried out to assess the protein expression levels of the apoptotic markers Bax …
Evaluation Of Two- Implant Assisted Mandibular Overdentures Of Cobalt Chromium Vs. Peek Combined Denture Bases Regarding Occlusion And Patient Satisfaction: A Within-Subject Study, Khaled M. Diaa, Noha H. El-Shaheed, May A. Hagag, Fatma A. El-Waseef
Evaluation Of Two- Implant Assisted Mandibular Overdentures Of Cobalt Chromium Vs. Peek Combined Denture Bases Regarding Occlusion And Patient Satisfaction: A Within-Subject Study, Khaled M. Diaa, Noha H. El-Shaheed, May A. Hagag, Fatma A. El-Waseef
Mansoura Journal of Dentistry
Objectives The purpose of this within-patient study was to compare two implant-assisted overdentures (IAOs) reinforced either with polyether-ether ketone (PEEK) or cobaltchromium (CO-CR) regarding the percentage of occlusal contact using a digital occlusion analysis system (Occlusense) and to assess patient satisfaction and Oral Health–Related Quality of Life (OHRQoL). Subjects and methods Ten complete edentulous subjects were eligible. All patients were delivered two mandibular implant-assisted overdentures with two reinforcement materials, CO-CR (group I) and PEEK (group II).The mandibular overdentures were retained to the underlying implant fixtures by ball and socket attachments. Patients were evaluated three months after each overdenture use. For …
The Prevalence Of Oral Mucosal Thermal And Chemical Burns Following Endodontic Treatments: A Multicenter Study, Mohamed Abd El Rahman El Shreif, Ahmed Adel Abdel-Azim, Noha Nasr El-Zalabany
The Prevalence Of Oral Mucosal Thermal And Chemical Burns Following Endodontic Treatments: A Multicenter Study, Mohamed Abd El Rahman El Shreif, Ahmed Adel Abdel-Azim, Noha Nasr El-Zalabany
Mansoura Journal of Dentistry
This multicenter retrospective study investigated the occurrence of oral mucosal thermal and chemical burns during endodontic operations conducted by dental students at Menoufia University (MU), Horus University in Egypt (HUE), and the Modern University for Technology and Information (MTI) over one year. A total of 4,791 clinical records were evaluated. MU identified 42 oral reactive lesions among 1,221 patients (3.4%), including 12 chemical and 30 thermal burns. HUE identified 63 lesions among 1,750 patients (3.6%), comprising 18 chemical and 45 thermal burns. MTI recorded 71 lesions among 1,820 patients (3.9%), including 21 cases of chemical and 50 cases of thermal …
Evaluation Of Retention And Wear Of Nylon Versus Polyether Ketone Ketone (Pekk) Inserts For Locator Attachments Retaining Mandibular Implant Overdenture: A Crossover Study, Mohamed Elghandour, Fatma Fathe Mahanna, Gilan Altonbary
Evaluation Of Retention And Wear Of Nylon Versus Polyether Ketone Ketone (Pekk) Inserts For Locator Attachments Retaining Mandibular Implant Overdenture: A Crossover Study, Mohamed Elghandour, Fatma Fathe Mahanna, Gilan Altonbary
Mansoura Journal of Dentistry
Objective: assessment and comparison between the retention and surface wear of nylon and polyether ketone ketone (PEKK) inserts of locator attachments retaining mandibular implant overdenture. Materials and methods: For this research, six patients, completely edentulous,were selected; each participant had received mandibular implants in the canine regions on each side, followed by locator attachments. Using a crossover design, patients were randomly assigned to receive different mandibular overdentures as follows. 1) Implantretained overdenture with nylon inserts; 2) Implant-retained overdenture with PEKK inserts. Retention measurements were conducted at three-time intervals: T0 (after pickup), T3 (3 months post-insertion of overdenture)and T6 (6 months post-insertion …
Relationship Extraction Using Retrieval Augmented Generation For Biomedical Dataset, Jannat Jannat
Relationship Extraction Using Retrieval Augmented Generation For Biomedical Dataset, Jannat Jannat
Theses and Dissertations
With the increasing number of structured and unstructured data, obtaining reliable information effectively has become crucial. In the biomedical domain, extracting information from the scientific papers is crucial in order to stay up-to-date with accurate information, given the increased pace by which new research studies are published. This work focuses on identifying relationships between entities that are extracted from the abstracts and titles of biomedical research papers. In this work, we developed a Retrieval Augmented Generation (RAG) based system to automatically identify relations between biomedical entities. We evaluate multiple open source Large Language Models (LLMs) and the number of examples …
Rubie K. Lee Photograph Albums, Zach S. Henderson Library Special Collections
Rubie K. Lee Photograph Albums, Zach S. Henderson Library Special Collections
Finding Aids
This collection consists of three photograph albums documenting Rubie K. Lee's work with the Methodist Church’s Women's Missionary Council (WMC) in Korea from the 1920s through the early 1930s. The photographs depict Korea under Japanese rule, showcasing its people and landscapes. Albums also contains photographs of the Ogeechee River flood of 1929, as well as an extensive collection of color postcards from Lee’s travels to Korea, Japan and China.
Georgia Southern Football Gameday Programs, Zach S. Henderson Library Special Collections
Georgia Southern Football Gameday Programs, Zach S. Henderson Library Special Collections
Finding Aids
The Georgia Southern Football Gameday Programs collection contains official publications produced for Georgia Southern University football games, most recently titled, Georgia Southern End Zone: The Official Publication of Eagle Football. The collection also features official gameday programs from away games, published by the hosting teams as well as special-issue editions from the postseason. These materials, spanning 1985-2009, document team rosters, coaches, statistics, and game information, offering a comprehensive record of Georgia Southern football events both at home and on the road.
Georgia Southern Honors Day Convocation Programs, Zach S. Henderson Library Special Collections
Georgia Southern Honors Day Convocation Programs, Zach S. Henderson Library Special Collections
Finding Aids
This collection contains programs from the Georgia Southern Honors Day Convocation event from 1935-2016.
Georgia Southern University Commencement Programs, Zach S. Henderson Library Special Collections
Georgia Southern University Commencement Programs, Zach S. Henderson Library Special Collections
Finding Aids
This collection consists of programs related to Georgia Southern University’s commencement ceremonies, with coverage from 1910 to 2025. Materials include official commencement programs as well as ancillary materials concerning commencement exercises and related events including student graduate lists.
The Role And Impact Of Forensic Evidence In The Prosecution Of Homicide Cases In The U.S., Afrah Dakhilallah A. Altubait
The Role And Impact Of Forensic Evidence In The Prosecution Of Homicide Cases In The U.S., Afrah Dakhilallah A. Altubait
Theses and Dissertations
The role of forensic evidence in the criminal justice process is an important topic that is significant from both theoretical and practical perspectives. The present study is dedicated to a critical analysis of the role of this evidence in the U.S. criminal justice process with a focus on its significance in homicide cases. Specifically, this dissertation examines the implications of using DNA and fingerprint evidence for convictions in U.S. homicide cases by analyzing the role of DNA and fingerprint evidence in the prosecution of “hot” and “cold” homicide cases, discussing the main ways in which forensic evidence assists with prosecuting …
Interleukin-15-Armoured Gpc3 Car T Cells For Patients With Solid Cancers, Purva Rathi, Amy N Courtney, Azlann B Arnett, Julien Fleurence, Ramy Sweidan, Tao Wang, Huimin Zhang, Prakash Masand, John M Maris, Daniel Martinez, Jennifer Pogoriler, Navin Varadarajan, Sachin G Thakkar, Deborah Lyon, Natalia Lapteva, Mei Zhuyong, Kalyani Patel, Dolores Lopez-Terrada, Carlos A Ramos, Premal Lulla, Tannaz Armaghany, Bambi J Grilley, Stephen Gottschalk, Gianpietro Dotti, Leonid S Metelitsa, Helen E Heslop, Malcolm K Brenner, Pavel Sumazin, Andras Heczey
Interleukin-15-Armoured Gpc3 Car T Cells For Patients With Solid Cancers, Purva Rathi, Amy N Courtney, Azlann B Arnett, Julien Fleurence, Ramy Sweidan, Tao Wang, Huimin Zhang, Prakash Masand, John M Maris, Daniel Martinez, Jennifer Pogoriler, Navin Varadarajan, Sachin G Thakkar, Deborah Lyon, Natalia Lapteva, Mei Zhuyong, Kalyani Patel, Dolores Lopez-Terrada, Carlos A Ramos, Premal Lulla, Tannaz Armaghany, Bambi J Grilley, Stephen Gottschalk, Gianpietro Dotti, Leonid S Metelitsa, Helen E Heslop, Malcolm K Brenner, Pavel Sumazin, Andras Heczey
Faculty, Staff and Students Publications
Interleukin-15 (IL15) promotes the survival of T lymphocytes and enhances the antitumor properties of CAR T cells in preclinical models of solid neoplasms in which CAR T cells have limited efficacy1-4. Glypican-3 (GPC3) is expressed in a group of solid cancers5-10, and here we report the first evaluation in humans of the effects of IL15 co-expression on GPC3-CAR T cells. Cohort 1 patients (NCT02905188/NCT02932956) received GPC3-CAR T cells, which were safe but produced no objective antitumor responses and reached peak expansion at two weeks. Cohort 2 patients ( …
A Multifunctional Theranostic Ultrasound Platform For Remote Magnetogenetics And Expanded Blood-Brain Barrier Opening, Guillaume Duret, Samantha L Gorman, Deny Tsakri, Rebecca L Noel, Robin Ji, Nancy Kwon, Quoc-Khanh Pham, Linlin Zhang, Gang Bao, Jacob T Robinson, Elisa E Konofagou
A Multifunctional Theranostic Ultrasound Platform For Remote Magnetogenetics And Expanded Blood-Brain Barrier Opening, Guillaume Duret, Samantha L Gorman, Deny Tsakri, Rebecca L Noel, Robin Ji, Nancy Kwon, Quoc-Khanh Pham, Linlin Zhang, Gang Bao, Jacob T Robinson, Elisa E Konofagou
Faculty, Staff and Students Publications
Introduction: Brain stimulation techniques are critical for unraveling the innerworkings of complex neuronal pathways governing both normal physiological function and pathologic states in neurological disorders. Focused ultrasound (FUS) is an emerging technique poised to significantly alter central nervous system (CNS) drug delivery and neuroscience research through non-invasive means. Magnetogenetics is a brain stimulation technique which may benefit from FUS technology in that alternating magnetic fields (AMF), like FUS, can pass through the skull without requiring surgery.
Methodology: Magnetogenetics involves the deposition of superparamagnetic iron-oxide nanoparticles (SPIONs) and overexpression of thermoreceptor transmembrane proteins (e.g. TRPV1 and TRPA1) in the brain. When …
Nanoparticle Contrast Agents For Photon-Counting Computed Tomography: Recent Developments And Future Opportunities, Eric A Tanifum, Ananth V Annapragada, Ketan B Ghaghada
Nanoparticle Contrast Agents For Photon-Counting Computed Tomography: Recent Developments And Future Opportunities, Eric A Tanifum, Ananth V Annapragada, Ketan B Ghaghada
Faculty, Staff and Students Publications
The clinical availability of photon-counting computed tomography (PCCT) has ushered in a new era of CT imaging. Spectral imaging coupled with superior contrast resolution, and ultrahigh spatial resolution (200 μm) offered by PCCT has the potential to revolutionize value-driven imaging. The potential of multicolor PCCT has generated excitement, and renewed interest, in novel contrast agent development for comprehensive disease interrogation, prediction and monitoring of treatment outcomes. Nanoparticles provide a versatile and powerful platform for the development of next generation contrast agents for spectral PCCT. In this article, we review recent developments and use of nanoparticle contrast agents for PCCT. We …
Private Property Vs. Public Access: Socio-Engineering Framework For Managing Non-Meandering Waters In South Dakota’S Prairie Pothole Region, Lydia Loken, Sushant Mehan
Private Property Vs. Public Access: Socio-Engineering Framework For Managing Non-Meandering Waters In South Dakota’S Prairie Pothole Region, Lydia Loken, Sushant Mehan
The Journal of Undergraduate Research
This study addresses the growing importance of balancing private ownership and public interest of Non-Meandering Waters (NMWs) overlaying private property in the South Dakota Prairie Pothole Region (PPR) through both a legal and socio-engineering lens. This study aims to develop an integrated management framework for Non-Meandering Waters in the South Dakota Prairie Pothole Region that combines water allocation principles, the Public Trust Doctrine, and water quality objectives to guide policy decisions, ensuring equitable access, long-term sustainability, and a balanced approach to both public and private interests. Data collection from October 2024 through February 2025 and included a literature review of …
An Adaptive Method For Covariate Balancing In Block Randomized Clinical Trials, Ren Rasnick
An Adaptive Method For Covariate Balancing In Block Randomized Clinical Trials, Ren Rasnick
Theses and Dissertations
Clinical trials are randomized in part to limit allocation bias, but also to ensure comparability between treatment arms for a baseline variable of concern. Comparable with regard to a baseline variable of concern is necessary for the validity of statistical methods. However, comparability is not guaranteed for trials of any size and is even more likely in trials with < 200 total participants. We propose a new method for adapting the allocation of participants in a sequentially allocated two-armed study with a small sample size to better ensure comparability.
The proposed method calculates the expected final imbalance (lack of comparability) based on the current participant values. Unlike several other methods, our method ensures the final desired sample size for each treatment arm, utilizes the expected final imbalance, increases comparability between …
Effectiveness Of Immersive Virtual Reality Combined With Task-Specific Training On Hemiplegic Arm Function Following Stroke: A Single Case Series Study, Rahsaan J. Holley
Effectiveness Of Immersive Virtual Reality Combined With Task-Specific Training On Hemiplegic Arm Function Following Stroke: A Single Case Series Study, Rahsaan J. Holley
Theses and Dissertations
Motor recovery of the arm following a neurological injury is a common goal of the rehabilitation process for individuals impacted by the condition . Due to the long-term functional implications of impaired arm movement, individuals are often trained to use compensatory strategies to complete functional tasks without incorporating the weakened limb. While compensatory strategies offer stroke survivors the opportunity to regain a level of independence, such approaches fail to directly address the underlying causes of the disability (i.e., limited range of motion, decreased strength, poor coordination, motor planning difficulties) which can unfortunately result in long-term impairment and functional disability.
Motor …
Improving Interprofessional Neurology Training Using Tele-Education
Improving Interprofessional Neurology Training Using Tele-Education
Faculty, Staff and Students Publications
Background: Neurological disorders are a leading cause of disability and death worldwide. Their burden on the health care system has substantially increased in the past 25 years, due to more effective treatments and longer life expectancies. The Veterans Health Administration has seen increases in neurology referrals and patients with neurologic disorders.
Observations: Collaborative efforts among primary care, geriatrics, neurology, psychiatry, physical medicine and rehabilitation, social work, and other disciplines are needed to properly care for veterans with neurologic disorders. Neurology education is an important tool for clinicians to better care for veterans with neurologic disorders. The use of technology and …
A Natural Small Molecule Isoginkgetin Alleviates Hypercholesterolemia And Atherosclerosis By Targeting Acly, Zhihua Wang, Zhenghong Liu, Chenyang He, Fanshun Zhang, Xiaojun Feng, Xiayun Ni, Yuanli Chen, Jixia Wang, Xinmiao Liang, Zhifu Xie, Jingya Li, Maciej Banach, Jaroslav Pelisek, Yuqing Huo, Yunhui Hu, Paul C Evans, Li Wang, Xiao-Yu Tian, Jianbo Xiao, Yuhua Shang, Yijun Zheng, Xunde Xian, Jianping Weng, Suowen Xu
A Natural Small Molecule Isoginkgetin Alleviates Hypercholesterolemia And Atherosclerosis By Targeting Acly, Zhihua Wang, Zhenghong Liu, Chenyang He, Fanshun Zhang, Xiaojun Feng, Xiayun Ni, Yuanli Chen, Jixia Wang, Xinmiao Liang, Zhifu Xie, Jingya Li, Maciej Banach, Jaroslav Pelisek, Yuqing Huo, Yunhui Hu, Paul C Evans, Li Wang, Xiao-Yu Tian, Jianbo Xiao, Yuhua Shang, Yijun Zheng, Xunde Xian, Jianping Weng, Suowen Xu
Faculty, Staff and Students Publications
Rationale: Atherosclerotic cardiovascular disease (ASCVD) represents the predominant cause of mortality and morbidity globally. Given the established role of hypercholesterolemia as a significant risk factor for ASCVD, the discovery of new lipid-lowering medications is of paramount importance. ATP citrate lyase (ACLY) is a crucial enzyme in cellular metabolism, providing acetyl-CoA as the building block for the biosynthesis of fatty acids and cholesterol. Consequently, it has emerged as a promising drug target for innovative treatments of lipid metabolic disorders.
Methods: Virtual screening of a natural product library was performed to identify small-molecule ACLY inhibitors, leading to the discovery of isoginkgetin (ISOGK). …