Digital Commons Network^™

Artificial Intelligence For The Detection Of Acute Myeloid Leukemia From Microscopic Blood Images; A Systematic Review And Meta-Analysis, Feras Al-Obeidat, Wael Hafez, Asrar Rashid, Mahir Khalil Jallo, Munier Gador, Ivan Cherrez-Ojeda, Daniel (Centro De Investigación De Salud Pública Y Epidemiología Clínica Simancas-Racines, , Universidad Ute, Quito, Ecuador , Universidad Ute, Quito, Ecuador

All Works

Leukemia is the 11th most prevalent type of cancer worldwide, with acute myeloid leukemia (AML) being the most frequent malignant blood malignancy in adults. Microscopic blood tests are the most common methods for identifying leukemia subtypes. An automated optical image-processing system using artificial intelligence (AI) has recently been applied to facilitate clinical decision-making. To evaluate the performance of all AI-based approaches for the detection and diagnosis of acute myeloid leukemia (AML). Medical databases including PubMed, Web of Science, and Scopus were searched until December 2023. We used the “metafor” and “metagen” libraries in R to analyze the different models used …

Development Of Spray-Dried Micelles, Liposomes, And Solid Lipid Nanoparticles For Enhanced Stability, Shradha Dattani, Xiaoling Li, Charina Lampa, Amanda Barriscale, Behzad Damadzadeh, David Lechuga-Ballesteros, Bhaskara R. Jasti

Pacific Faculty Work

Objectives: Micelles, liposomes, and solid lipid nanoparticles (SLNs) are promising drug delivery vehicles; however, poor aqueous stability requires post-processing drying methods for maintaining long-term stability. The objective of this study was to compare the potential of lipid-based micelles, liposomes, and SLNs for producing stable re-dispersible spray-dried powders with trehalose or a combination of trehalose and L-leucine. This study provides novel insights into the implementation of spray drying as a technique to enhance long-term stability for these lipid-based nanocarriers. Methods: Aqueous dispersions of LDV-targeted micelles, liposomes, and SLNs loaded with paclitaxel (PTX) were converted into re-dispersible powders using spray drying. The …

Rural, Gifted Student Experience In Appalachian Kentucky, Olivia G. Jarrell

Graduate Theses, Dissertations, and Capstones

Current literature shows that gifted students' experiences often differ from nongifted peers. Similarly, research shows that rural students’ experiences are unique compared to nonrural peers. This study hopes to address the gap in literature on experiences of students at the intersection of giftedness and rurality with the question: How do rural, gifted students in Appalachian Kentucky experience and perceive K-12 schooling? Rural, gifted students exist in the overlap between two unique groups. Using a multi-case study, participants came from three separate school districts in a region of Appalachian Kentucky, with each district being a separate case. Data collection included observations …

Nkapl Facilitates Transcription Pause-Release And Bridges Elongation To Initiation During Meiosis Exit, Jie Gong, Ruoyu Yan, Gan Luo, Yuanyuan Wang, Qing He, Yifei Wu, Yitong Yan, Baomei Qian, Shenglin Han, Zhiwen Bu, Jinwen Zhang, Xian Xia, Liang Chen, Zhibin Hu, Mingyan Lin, Zheng Sun, Yayun Gu, Lan Ye

Faculty, Staff and Students Publications

Transcription elongation, especially RNA polymerase II (Pol II) pause-release, is less studied than transcription initiation in regulating gene expression during meiosis. It is also unclear how transcription elongation interplays with transcription initiation. Here, we show that depletion of NKAPL, a testis-specific protein distantly related to RNA splicing factors, causes male infertility in mice by blocking the meiotic exit and downregulating haploid genes. NKAPL binds to promoter-associated nascent transcripts and co-localizes with DNA-RNA hybrid R-loop structures at GAA-rich loci to enhance R-loop formation and facilitate Pol II pause-release. NKAPL depletion prolongs Pol II pauses and stalls the SOX30/HDAC3 transcription initiation complex …

Impact Of Leadership Characteristics Of Empowerment And Support Of Employee Growth On Job Commitment And Turnover Intent Of Nurses In Ghana, Ernest Addai Duah

Walden Dissertations and Doctoral Studies

Prior studies have examined leadership style and its relation to healthcare employees’ performance; however, few Ghanaian studies have focused on using characteristics of leaders and their relationship to job commitment and turnover intention among nurses and midwives in the 10 regions of Ghana. The objective for this quantitative correlation study was to examine whether leadership characteristics have a relationship with job commitment and turnover intent among hospital nurses in Ghana, where Upper East was the region of focus. Servant leadership theory was used as the theoretical framework for this study. The study addressed the relationship between leadership characteristics of empowerment, …

Impact Of Leadership Characteristics Of Empowerment And Support Of Employee Growth On Job Commitment And Turnover Intent Of Nurses In Ghana, Ernest Addai Duah

Walden Dissertations and Doctoral Studies

Prior studies have examined leadership style and its relation to healthcare employees’ performance; however, few Ghanaian studies have focused on using characteristics of leaders and their relationship to job commitment and turnover intention among nurses and midwives in the 10 regions of Ghana. The objective for this quantitative correlation study was to examine whether leadership characteristics have a relationship with job commitment and turnover intent among hospital nurses in Ghana, where Upper East was the region of focus. Servant leadership theory was used as the theoretical framework for this study. The study addressed the relationship between leadership characteristics of empowerment, …

Update On Pediatric Surveillance Recommendations For Pten Hamartoma Tumor Syndrome, Dicer1-Related Tumor Predisposition, And Tuberous Sclerosis Complex, Sarah G Mitchell, Junne Kamihara, Alexander T Nelson, Paige H R Mallinger, Jack J Brzezinski, Kara N Maxwell, Emma R Woodward, Bailey Gallinger, Sun Young Kim, Mary-Louise C Greer, Kami Wolfe Schneider, Sarah R Scollon, Anirban Das, Jonathan D Wasserman, Charis Eng, David Malkin, William D Foulkes, Orli Michaeli, Andrew J Bauer, Douglas R Stewart

Faculty, Staff and Students Publications

Phosphate and tensin homolog hamartoma tumor syndrome, DICER1-related tumor predisposition, and tuberous sclerosis complex are rare conditions, which each increases risk for distinct spectra of benign and malignant neoplasms throughout childhood and adulthood. Surveillance considerations for each of these conditions focus on patient and family education, early detection, and multidisciplinary care. In this article, we present updated surveillance recommendations and considerations for children and adolescents with phosphate and tensin homolog hamartoma tumor syndrome, DICER1-related tumor predisposition, and tuberous sclerosis complex and provide suggestions for further research in each of these conditions.

Barcoded Sars-Cov-2 Viruses Define The Impact Of Duration And Route Of Exposure On The Transmission Bottleneck In A Hamster Model, Reed Trende, Tamarand L Darling, Tianyu Gan, David Wang, Adrianus C M Boon

2020-Current year OA Pubs

The transmission bottleneck, defined as the number of viruses shed from one host to infect another, is an important determinant of the rate of virus evolution and the level of immunity required to protect against virus transmission. Despite its importance, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission bottleneck remains poorly characterized. We adapted a SARS-CoV-2 reverse genetics system to generate a pool of >200 isogenic SARS-CoV-2 viruses harboring specific 6-nucleotide barcodes, infected donor hamsters with this pool, and exposed contact hamsters to paired infected donors, varying the duration and route of exposure. Following exposure, the nasal turbinates, trachea, …

Recommendations For Interdisciplinary Research Collaboration For Early Career Dissemination And Implementation Researchers: A Multi-Phase Study, Hannah G Lane, Sallie D Allgood, Julie Schexnayder, Hayden B Bosworth, Ana A Baumann, Allison A Lewinski

2020-Current year OA Pubs

INTRODUCTION: Dissemination and implementation (D&I) scientists are key members of collaborative, interdisciplinary clinical and translational research teams. Yet, early career D&I researchers (ECRs) have few guidelines for cultivating productive research collaborations. We developed recommendations for ECRs in D&I when serving as collaborators or co-investigators.

METHODS: We employed a consensus-building approach: (1) group discussions to identify 3 areas of interest: "Marketing yourself" (describing your value to non-D&I collaborators), "Collaboration considerations

RESULTS: Forty-four D&I researchers completed the first survey, 12 of whom attended one of three focus groups. Twenty-nine D&I researchers completed the second survey (

CONCLUSIONS: Research collaborations are essential in …

Investigating The Role Of The Nsp15 Amino-Terminal Domain In Nsp15 Function, Viral Replication, And Pathogenesis, Monika Evdokimova

Dissertations

Identifying conserved mechanisms used by viruses to delay host innate responses can reveal potential targets for antiviral therapeutics. Here, we investigated coronavirus nonstructural protein 15 (nsp15), which encodes a highly conserved endoribonuclease (EndoU). EndoU functions as an immune antagonist by limiting the accumulation of viral replication intermediates that would otherwise be sensed by the host. Despite being a promising antiviral target, it has been difficult to develop small molecule inhibitors that target the EndoU active site. We generated nsp15 mutants of SARS-CoV-2 and mouse coronavirus MHV-A59 and identified conserved residues within the amino-terminal domain that are required for EndoU activity. …

Maximum Spread Of KS,T - Minor-Free Graphs, William Linz, Linyuan Li, Zhiyu Wang

Faculty Publications

The spread of a graph G is the difference between the largest and smallest eigenvalue of the adjacency matrix of G. In this paper, we consider the family of graphs which contain no K_s,t-minor. We show that for any t ≥ s ≥ 2 and sufficiently large n, there is an integer ξ_t such that the extremal n-vertex K_s,t-minor-free graph attaining the maximum spread is the graph obtained by joining a graph L on (s − 1) vertices to the disjoint union of ⌊(2n + ξ …

Re: Approval Letter For The Butte Priority Soils Operable Unit (Bpsou) Draft Residential Metals Abatement Program Investigation Summary Report (Non‐Residential Parcels – Indoor Dust) – Cccs Gym Annex (Dated October 4, 2024), Molly Roby

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Butte Priority Soils Operable Unit (Bpsou) Final Bpsou Insufficiently Reclaimed Sites Belle Of Butte (Bres No. 8 & Ur-39) Remedial Action Work Plan (Rawp) Request For Change Ir- 2024-Ra-01, Mike Mcanulty

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Targeting Trpc Channels For Control Of Arthritis-Induced Bone Erosion, Aidan Douglas, Brady Nicewarner, Casey Hall, Klaus Groschner, Bernadett Bacsa, Werner Geldenhuys, Michael X Zhu, Harry C Blair, John B Barnett, Jonathan Soboloff

Faculty, Staff and Student Publications

Arthritis leads to bone erosion due to an imbalance between osteoclast and osteoblast function. Our prior investigations revealed that the Ca2+-selective ion channel, Orai1, is critical for osteoclast maturation. Here, we show that the small-molecule ELP-004 preferentially inhibits transient receptor potential canonical (TRPC) channels. While ELP-004 minimally affected physiological RANKL-induced osteoclast maturation in murine bone marrow- and spleen-derived myeloid cells (BMSMCs) and human PBMC-derived cells, it potently interfered with osteoclast maturation driven by TNFα or LTB4. The contribution of TRPC channels to osteoclastogenesis was examined using BMSMCs derived from TRPC4-/- or TRPC(1-7)-/- mice, again revealing preferential interference with osteoclastogenesis driven …

Chemical Damping Of The Motion Of A Piston: Irreversibilities Arising From Nonequilibrium Conditions On The Chemical Potential, David S. Corti, Mark J. Uline

Faculty Publications

We revisit the thermodynamic analysis of an isothermal ideal gas mixture enclosed within a cylinder and separated from the surrounding atmosphere by a movable and frictionless piston. When equilibrium conditions based on the chemical potentials of one or more species in the mixture are not satisfied at all times, which occurs for example for a chemical reaction with finite and non-zero reaction rates in the forward and reverse directions and for mass transfer of one species across a permeable membrane occurring at a finite and non-zero rate, an irreversibility is necessarily introduced into the system with a resulting increase in …

Depictions Of United States Military Domestic Violence Found On The Internet, Erica Ann Pearson

Walden Dissertations and Doctoral Studies

Military domestic violence (MDV) is an issue in the United States. The purpose of this generic qualitative study was to explore how the mainstream media and published government content depicts MDV on the internet, and whether those narratives/video transcripts contained any agenda to generate influence. Ragas’ agenda-setting theory was used as a framework for this study. Agenda-setting is a communication specific phenomenon directed to influence individuals or organizations, based on what public relations practitioners present to the public. There are two research questions in this study. The first is: How do mainstream media narratives, and government documents depict survivors and …

Attachment Styles Predicting School Engagement In Nontraditional Graduate Students, Aline Benamou-Fruchter

Walden Dissertations and Doctoral Studies

Understanding how attachment styles influence nontraditional graduate students’ engagement is essential for advancing theoretical knowledge and developing targeted support systems in higher education. While research confirms that attachment styles affect academic outcomes, including perceptions of institutional support and learning environments, nontraditional graduate students remain underrepresented in engagement studies. Using Bowlby’s attachment theory as a guiding framework, this study investigated the relationship between secure, anxious, and avoidant attachment styles and behavioral, emotional, and cognitive engagement. The Attachment Style Questionnaire, University Student Engagement Inventory, and a sociodemographic survey were employed, with data analyzed through a one-way MANOVA. Significant differences were found between …

Perceptions Of Coping Capacity And Burnout Among Psychiatric Social Workers, Akia Sheree Pittman

Walden Dissertations and Doctoral Studies

U.S. mental health social workers practicing in psychiatric settings are susceptible to developing burnout. Burnout is a prominent and enduring social problem faced by many helping professionals, but especially among licensed mental health social workers. The purpose of this generic qualitative study was to explore the role coping capacity plays in mental health social workers developing burnout while employed in an inpatient psychiatric setting. The conceptual framework was sense of coherence, a core construct of the salutogenic theory of health. Data were collected from semistructured interviews with 10 clinical social workers employed in inpatient psychiatric settings in North Carolina. Data …

First-Generation African American College Graduates’ Interpretations Of Poverty And Well-Being, Shermanda Bellsora Whitfield

Walden Dissertations and Doctoral Studies

The number of first-generation African American graduates of postsecondary institutions has grown, as many individuals perceive degree completion as a way to overcome socioeconomic barriers. The problem was that some first-generation African American college graduates face economic challenges postgraduation, living at or below the poverty level. It was unclear how this condition affected their quality of life. The purpose of this generic qualitative study was to understand how African American first-generation college graduates interpreted and made meaning of their experiences related to their financial status and personal well-being. Bronfenbrenner’s ecological systems was the theoretical framework. Data were collected through semi-structured …

Prevalent Themes Of Messages Related To Sexual Risk Behaviors Targeting Young Black Women In Social Media, Dominique Lache' Gadson

Walden Dissertations and Doctoral Studies

Black women have been shown in mainstream media and social media in ways that reinforce negative stereotypes and reduce them to objects, which leads to the sexualization and stigmatization of their bodies and sexuality. There was a gap in understanding how exposure to social media content may influence sexual behavior and identity among young Black women, and how hypersexualized narratives sparked by stories in social media reflect sexual risk-taking. The purpose of this qualitative study was to explore and track popular social media sites to determine the themes of the messages most frequently viewed targeting Black women. The research question …

Elementary School Teachers’ Perspectives Regarding Handwriting Fluency And Writing Proficiency In Elementary Students, Sofia Doyle For Scott Doyle

Walden Dissertations and Doctoral Studies

The problem that was addressed in this study is that the majority of students nationwide demonstrate low writing proficiency and handwriting fluency. The purpose of this study was to explore elementary school teachers’ perspectives regarding handwriting fluency and its role in the overall writing skills of elementary students. This study was grounded in Piaget’s cognitive learning theory. Four research questions focused on teachers’ perspectives; two questions focused on factors that contribute to low achievement in handwriting and writing proficiency and two questions asked teachers about their experiences with the strategies they used to support students in handwriting and writing achievement. …

Preventing Burnout In Nursing Staff: Strategies And Best Practices For A Healthy Workplace, Friday Chidozie Nwabuisi

Walden Dissertations and Doctoral Studies

This doctoral project is a staff education initiative focused on improving nursing resilience and mental health through mindfulness-based interventions (MBIs). The project was informed by a practice-focused question: To what extent does the implementation of MBI training reduce stress and burnout among nursing staff in a clinical setting? The purpose of this project was to establish whether MBIs can be implemented as a support strategy in mitigating burnout and stress among nurses. The quantitative evaluation strategy used to determine the effectiveness of MBIs in reducing stress and burnout among nurses was a pretest and a posttest. The project targeted nursing …

Understanding Covid-19 Vaccination Hesitance Among Registered Nurses, Lucille Fenelon

Walden Dissertations and Doctoral Studies

The development of the COVID-19 vaccine, while hailed as a groundbreaking scientific achievement, also brought to light a discernible hesitance from registered nurses (RNs) regarding the vaccination. While extensive research has delved into the broader phenomenon of vaccination hesitancy, there remains a notable gap in comprehensively examining the specific lived experiences of RNs in relation to this hesitancy. Thus, the purpose of this study was to explore the lived experiences of RNs contributing to COVID-19 vaccine hesitance within the context of the theory of reasoned action (TRA) and Roy’s adaptation model. TRA helped to guide this study in identifying the …

Perceptions Of Encouragement For Native American Women To Persist In Doctoral Programs, Venicia Mayo Burton

Walden Dissertations and Doctoral Studies

The problem addressed in this study is the underrepresentation of Native American women in doctoral programs in the United States. The purpose of this basic qualitative study was to explore how encouragement in terms of support, confidence, hope, and advice received from family and tribe, friends and social circles, and faculty and college administrators influence the persistence of Native American women in their doctoral journeys. The conceptual framework for this study is the psychosociolcultural theory (PSC) to help examine the psychological, social, and cultural influences on the educational experiences of minority students in an educational setting. Data from eight interviews …

Depictions Of United States Military Domestic Violence Found On The Internet, Erica Ann Pearson

Walden Dissertations and Doctoral Studies

Military domestic violence (MDV) is an issue in the United States. The purpose of this generic qualitative study was to explore how the mainstream media and published government content depicts MDV on the internet, and whether those narratives/video transcripts contained any agenda to generate influence. Ragas’ agenda-setting theory was used as a framework for this study. Agenda-setting is a communication specific phenomenon directed to influence individuals or organizations, based on what public relations practitioners present to the public. There are two research questions in this study. The first is: How do mainstream media narratives, and government documents depict survivors and …

Attachment Styles Predicting School Engagement In Nontraditional Graduate Students, Aline Benamou-Fruchter

Walden Dissertations and Doctoral Studies

Understanding how attachment styles influence nontraditional graduate students’ engagement is essential for advancing theoretical knowledge and developing targeted support systems in higher education. While research confirms that attachment styles affect academic outcomes, including perceptions of institutional support and learning environments, nontraditional graduate students remain underrepresented in engagement studies. Using Bowlby’s attachment theory as a guiding framework, this study investigated the relationship between secure, anxious, and avoidant attachment styles and behavioral, emotional, and cognitive engagement. The Attachment Style Questionnaire, University Student Engagement Inventory, and a sociodemographic survey were employed, with data analyzed through a one-way MANOVA. Significant differences were found between …

First-Generation African American College Graduates’ Interpretations Of Poverty And Well-Being, Shermanda Bellsora Whitfield

Walden Dissertations and Doctoral Studies

The number of first-generation African American graduates of postsecondary institutions has grown, as many individuals perceive degree completion as a way to overcome socioeconomic barriers. The problem was that some first-generation African American college graduates face economic challenges postgraduation, living at or below the poverty level. It was unclear how this condition affected their quality of life. The purpose of this generic qualitative study was to understand how African American first-generation college graduates interpreted and made meaning of their experiences related to their financial status and personal well-being. Bronfenbrenner’s ecological systems was the theoretical framework. Data were collected through semi-structured …

Perceptions Of Coping Capacity And Burnout Among Psychiatric Social Workers, Akia Sheree Pittman

Walden Dissertations and Doctoral Studies

U.S. mental health social workers practicing in psychiatric settings are susceptible to developing burnout. Burnout is a prominent and enduring social problem faced by many helping professionals, but especially among licensed mental health social workers. The purpose of this generic qualitative study was to explore the role coping capacity plays in mental health social workers developing burnout while employed in an inpatient psychiatric setting. The conceptual framework was sense of coherence, a core construct of the salutogenic theory of health. Data were collected from semistructured interviews with 10 clinical social workers employed in inpatient psychiatric settings in North Carolina. Data …

Prevalent Themes Of Messages Related To Sexual Risk Behaviors Targeting Young Black Women In Social Media, Dominique Lache' Gadson

Walden Dissertations and Doctoral Studies

Black women have been shown in mainstream media and social media in ways that reinforce negative stereotypes and reduce them to objects, which leads to the sexualization and stigmatization of their bodies and sexuality. There was a gap in understanding how exposure to social media content may influence sexual behavior and identity among young Black women, and how hypersexualized narratives sparked by stories in social media reflect sexual risk-taking. The purpose of this qualitative study was to explore and track popular social media sites to determine the themes of the messages most frequently viewed targeting Black women. The research question …

Elementary School Teachers’ Perspectives Regarding Handwriting Fluency And Writing Proficiency In Elementary Students, Sofia Doyle For Scott Doyle

Walden Dissertations and Doctoral Studies

The problem that was addressed in this study is that the majority of students nationwide demonstrate low writing proficiency and handwriting fluency. The purpose of this study was to explore elementary school teachers’ perspectives regarding handwriting fluency and its role in the overall writing skills of elementary students. This study was grounded in Piaget’s cognitive learning theory. Four research questions focused on teachers’ perspectives; two questions focused on factors that contribute to low achievement in handwriting and writing proficiency and two questions asked teachers about their experiences with the strategies they used to support students in handwriting and writing achievement. …