Digital Commons Network^™

Aerocom: Summer 2025, John D. Odegard School Of Aerospace Sciences

Aerocom: John D. Odegard School of Aerospace Sciences Alumni Magazine

No abstract provided.

Expanding Equity And Innovation In Pharmaceutical Law And Drug Development: Paying Clinical Trial Participants For Their Data, Steve Calandrillo, Bernadette Tosti, Jefferson Smith, Jamison Koeman

Articles

Bringing a drug to market is exceedingly expensive and exposes pharmaceutical manufacturers to significant legal risk. But when companies are successful, their profits make the PowerBall jackpot look like petty cash. Staggering rewards measure in the billions or millions for the firms, CEOs, pharmacies, drug benefit managers, data brokers, and many more actors in the pharmaceutical-to-patient pipeline. The only individuals who don’t get paid handsomely are the clinical trial participants, whose voluntary participation and data helped make those successes possible. It is long past time that we reform the legal and regulatory roadblocks to paying clinical trial participants in the …

Institute For Global Health And Development : Issue 11 - July 2025, Institute For Global Health And Development

IGHD Newsletters

• Climate Change, Water, And the Way Forward
• Dr. Zulfiqar Bhutta Joins Global Panel on CGTN America For World Health Day 2025
• IGHD Welcomes New Associate Faculty Members
• Dr. Zulfiqar A. Bhutta Named American Society For Nutrition (ASN) Distinguished Fellow 2025
• IGHD’s Dr. Ammad Qazi Delivers Keynote Address at AKU Climate Change Event
• New IGHD Research Project to Develop Sustainable Health Infrastructure in LMICS

CLIMATE CHANGE, WATER, AND THE WAY FORWARD

Methods For Meaningful Connection: Supporting Teacher-Child Relationships In Early Care And Education, Sheila Smith, Maribel Granja, Cristina Medellin, Mark Nagasawa

Straus Institute for Thriving Children & Families

This report discusses a combined professional development/exploratory research project focused on how to support relationships between early childhood educators and children. The project piloted the Teacher Reflection Tool (TRT), a very brief reflection tool, paired with a community of practice approach with 19 early childhood educators across 10 classrooms. Among the lessons learned were that the participants:

• Viewed positive relationships with children as family-like and individualized
• Observed that their relationships with parents influenced relationships with children
• Found that the TRT helped them to notice and reflect on their interactions with children in new ways

Among the recommendations that emerged were: …

Empowering Researchers Through An Open Access Publishing Fund: A Case Study Of Clemson University Libraries, Karen Burton, Amal Mostafa

Publications

This session explores Clemson Libraries’ Open Access Publishing Fund’s transition from a “first come, first served” to a rubric-based model. We’ll discuss implementation challenges, key insights from faculty surveys, and subsequent rubric revisions, highlighting the importance of adaptability, continuous improvement, and using a data-informed approach to meet the evolving needs of researchers.

The Effect Of Anterior Closing Wedge Slope-Reducing Osteotomy On Coronal Alignment-Effect Of Osteotomy Technique, Starting Point, And Degree Of Correction., James Matthew Helm, Mark Coggins, Brian Crowley, Maile Curbo, Jacob Siahaan, Alexis Aboulafia, Alfred A Mansour

Faculty, Staff and Student Publications

Background: Techniques for anterior closing wedge slope-reducing osteotomy (ACW-SRO) remain variable regarding management of the tibial tubercle and osteotomy starting point. Moreover, the potential unintended effect on coronal alignment has not yet been determined.

Purpose: To determine the effect of the ACW-SRO technique and starting point on coronal alignment in knees with an elevated posterior tibial slope (PTS).

Study design: Descriptive laboratory study.

Methods: Full-length lower extremity computed tomography scans were retrospectively reviewed in patients presenting to our level 1 trauma center to identify patients with an elevated PTS of ≥12° without secondary trauma to the lower extremity. Materialise software …

A Recipe For Disaster - Sodium Bicarbonate Overdose, Adeola A Kosoko, Amara Ogoke, Kyle Vogt

Faculty, Staff and Student Publications

Audience: Emergency medicine residents post-graduate years 1-4.

Introduction: Sodium bicarbonate is a compound found commonplace in many households and in many products. It lends itself to countless everyday uses including cooking and cleaning. Physicians prescribe sodium bicarbonate regularly both on- and off-label regularly for various ailments.1 Due to the ubiquitous way both emergency physicians and the general public use and are exposed to sodium bicarbonate, we wanted to prepare learners to identify and appropriately manage sodium bicarbonate toxicity.Obtaining a thorough history not just of medications prescribed but of significant ingestions or infusions is critical in diagnosing this toxicity. Furthermore, acute …

Efficacy And Safety Of Mechanical Thrombectomy In Distal Medium Middle Cerebral Artery Occlusion Ischemic Stroke Patients On Low-Dose Aspirin, Hamza Adel Salim, Vivek Yedavalli, Fathi Milhem, Basel Musmar, Nimer Adeeb, Motaz Daraghma, Kareem El Naamani, Nils Henninger, Sri Hari Sundararajan, Anna Luisa Kühn, Jane Khalife, Sherief Ghozy, Luca Scarcia, Benjamin Yq Tan, Robert W Regenhardt, Jeremy J Heit, Nicole M Cancelliere, Joshua D Bernstock, Aymeric Rouchaud, Jens Fiehler, Sunil Sheth, Ajit S Puri, Christian Dyzmann, Marco Colasurdo, Leonardo Renieri, João Pedro Filipe, Pablo Harker, Răzvan Alexandru Radu, Mohamad Abdalkader, Piers Klein, Thomas R Marotta, Julian Spears, Takahiro Ota, Ashkan Mowla, Pascal Jabbour, Arundhati Biswas, Frédéric Clarençon, James E Siegler, Thanh N Nguyen, Ricardo Varela, Amanda Baker, Muhammed Amir Essibayi, David Altschul, Nestor R Gonzalez, Markus A Möhlenbruch, Vincent Costalat, Benjamin Gory, Christian Paul Stracke, Constantin Hecker, Hamza Shaikh, Christoph J Griessenauer, David S Liebeskind, Alessandro Pedicelli, Andrea M Alexandre, Illario Tancredi, Tobias D Faizy, Erwah Kalsoum, Max Wintermark, Boris Lubicz, Aman B Patel, Vitor Mendes Pereira, Adrien Guenego, Adam A Dmytriw

Faculty, Staff and Student Publications

Background: Acute ischemic stroke (AIS) from distal medium vessel occlusion (DMVO) presents unique treatment challenges. Mechanical thrombectomy (MT) is emerging as a viable option for these patients, yet the role of pre-stroke aspirin treatment is unclear. This study evaluates the impact of pre-stroke low-dose aspirin on outcomes in DMVO patients undergoing MT.

Methods: We conducted a multinational, multicenter, propensity score-weighted analysis within the Multicenter Analysis of primary Distal medium vessel occlusions: effect of Mechanical Thrombectomy (MAD-MT) registry. Patients with AIS due to DMVO, treated with MT, were included. We compared outcomes between patients on pre-stroke low-dose aspirin (75-100 mg) and …

Psy News, Summer 2025, Illinois State University, Department Of Psychology

Psych News

Newsletter of the Department of Psychology

Interconnections Of Insulin/Igf-1 Signaling And Autophagy Abnormalities In Alzheimer’S Disease, Wang Liao, Jinfeng Xuan, Woo-In Ryu, Mariana K Bormann, Yoon Lee, Haley Dion, Elizabeth Evangelista, Ruiyi Li, Lucas Trambaiolli, Jun Liu, Arthur J Siegel, Brent P Forester, Bruce M Cohen, Kai-Christian Sonntag

Faculty, Staff and Student Publications

Introduction: Impaired insulin (INS) and insulin-like growth factor 1 (IGF-1) signaling are features of both brain aging and late-onset Alzheimer's disease (LOAD). However, their exact underlying mechanisms and cause-and-effect linkages, including the downstream regulation of endocytosis and autophagy, are still not well understood.

Methods: We investigated INS/IGF-1 signaling and its connection with endocytic and autophagic processes in fibroblasts from LOAD patients and healthy young or old control individuals.

Results: Compared to control old-age cells, protein levels in the INS/IGF-1 signaling cascade were elevated in LOAD cells, but activation of AKT was reduced. The activation of the INS/IGF-1/AKT/FOXO1 or mTOR axes …

Arterial Anastomosis To Injured Vessels: Outcomes In Lower Extremity Trauma Reconstruction, Ellen Wang, Jessica R Nye, Imran Rizvi, Kylie R Swiekatowski, Bora Kahramangil, Paul Won, Noa G Kopplin, Stephen F Parlamas, Jeffrey G Trost, Mohin A Bhadkamkar

Faculty, Staff and Student Publications

Background: Although traditional teaching advocates that microsurgical anastomoses should be performed to uninjured vessels outside the zone of injury (ZOI), there is no defined way to assess the extent of the ZOI, and uninjured vessels may not be available. To evaluate the complications ascribed to the ZOI and injured vessels, outcomes between arterial anastomoses fashioned from within the ZOI versus noninjured recipient vessels were compared.

Methods: A retrospective review was conducted of adult patients who required lower extremity free flap (FF) reconstruction from 2016 to 2024. Injury to the recipient artery (transection, avulsion, or thrombosis) was determined by intraoperative assessment …

2025 Illinois Shakespeare Festival Program, School Of Theatre, Dance, And Film

Illinois Shakespeare Festival

2025 Season. The Professional Theatre and Illinois State University, Ewing Theatre. A Midsummer's Night's Dream by William Shakespeare. Hamlet by William Shakespeare. The Importance of Being Ernest by Oscar Wilde.

Endovascular Therapy For Late-Window M2-Segment Middle Cerebral Artery Occlusion: Analysis Of The Clear Study, Simon Winzer, Daniel P O Kaiser, Muhammad M Qureshi, Alicia C Castonguay, Daniel Strbian, Raul G Nogueira, Simon Nagel, Jean Raymond, Mohamad Abdalkader, Jelle Demeestere, João Pedro Marto, Hiroshi Yamagami, Kanta Tanaka, Sunil A Sheth, Anne Dusart, Patrik Michel, Marta Olive Gadea, Marc Ribo, Osama O Zaidat, Diogo C Haussen, Hilde Henon, Mahmoud H Mohammaden, Markus A Möhlenbruch, James E Siegler, Ajit S Puri, Johannes Kaesmacher, Piers Klein, Liisa Tomppo, Francois Caparros, João Nuno Ramos, Mouhammad Jumaa, Syed Zaidi, Nicolas Martinez-Majander, Stefania Nannoni, Lieselotte Vandewalle, Flavio Bellante, Milagros Galecio-Castillo, Sergio Salazar-Marioni, Pekka Virtanen, Anke Wouters, Rita Ventura, Jessica Jesser, Adnan Mujanovic, Liqi Shu, Abiya Qureshi, Zhongming Qiu, Hesham E Masoud, Manuel Requena, Mikko Sillanpää, Wei Hu, Eugene Lin, Charlotte Cordonnier, Daniel Roy, Shadi Yaghi, Davide Strambo, Urs Fischer, Santiago Ortega-Gutierrez, Robin Lemmens, Peter A Ringleb, Thanh N Nguyen, Volker Puetz

Faculty, Staff and Student Publications

Background: There is uncertainty about whether patients with M2 occlusion benefit from endovascular therapy (EVT) in the late (6-24-hour) time window. We evaluated the clinical outcomes of patients with M2 occlusion selected for EVT compared with those who received medical management (MM) in the late window.

Methods: This multinational cohort study was conducted at 66 sites across 10 countries (January 2014 to May 2022). We included consecutive patients with late-window stroke due to M2 occlusion, baseline National Institutes of Health Stroke Scale score of ≥5, and premorbid modified Rankin Scale score of ≤2 who received EVT or MM alone. The …

A Case Of Aqp4-Igg Neuromyelitis Optica Presenting With Orbital Inflammatory Syndrome, Lucy A Bailey, Roy F Riascos, Ore-Ofe O Adesina

Faculty, Staff and Student Publications

A 45-year-old healthy African-American man experienced 2 months of right-eye soreness followed by acute onset of right painful vision loss with binocular, oblique diplopia. Visual acuity was count fingers OD and 20/20 OS. He had a partial, right, pupil-involving cranial nerve III palsy with a right relative afferent pupillary defect and optic disc edema with tortuous vessels. Magnetic resonance imaging showed increased T2 signal with tortuosity and thickening of the retrobulbar right optic nerve with associated restricted diffusion and enhancement, enhancement of orbital fat adjacent to the optic nerve sheath, and relative right proptosis. Workup was positive for aquaporin-4 antibody …

Encephalitis In Immunocompromised Vs Immunocompetent Patients: A Comparative Study, Anna Kolchinski, Margaret Li, Ralph Habis, Paris Bean, Ashley N Heck, John C Probasco, Rodrigo Hasbun, Arun Venkatesan

Faculty, Staff and Student Publications

Background: Encephalitis is characterized by brain parenchymal inflammation caused by infection or autoimmunity. There are limited recent data on how immunocompromised patients with encephalitis differ from the general encephalitis population.

Methods: This retrospective study of 2 large medical institutions compares clinical characteristics and outcomes of immunocompromised and immunocompetent patients with all-cause encephalitis.

Results: Of the 657 patients, 151 (23%) were immunocompromised. Immunocompromised patients were more likely to have an infectious etiology, comorbidities, inflammatory cerebrospinal fluid (CSF) profile, abnormal neuroimaging, and worse clinical outcomes as assessed by discharge Glasgow Outcome Scale (GOS) and in-hospital mortality (all P < .05). The most commonly identified etiologies in immunocompromised patients were herpes simplex virus (HSV) and varicella zoster virus. HSV accounted for similar proportions in the immunocompromised (18%) and immunocompetent (14%) groups, though it was more commonly associated with a CSF neutrophilia in the immunocompromised group (P = .001). Strikingly, …

Evolving Hemodynamics In Fontan Circulation: Age-Driven Insights In Patients With Interrupted Inferior Vena Cava And Hepatoazygos Shunt, Vikas Kannojiya, Akshita Sahni, Emily Eickhoff, Neha Zacharia, Nicole St Clair, Noah Schulz, Peter E Hammer, Pedro J Del Nido, Rahul H Rathod, David M Hoganson, Vijay Govindarajan

Faculty, Staff and Student Publications

Patients with interrupted inferior vena cava (I-IVC) and azygos continuation who undergo Fontan completion via hepatoazygos shunting exhibit unique hemodynamic challenges. This study evaluates age-related shifts in systemic venous return dominance, hepatic flow distribution (HFD), power loss (PL), and flow disturbances using patient-specific computational fluid dynamics (CFD). Data analysis from 95 patients with I-IVC showed a nonlinear shift in upper-to-lower body systemic flow dominance with ratios of 2, 1, and 0.5 (correlating to ages ∼3, ∼10, and ∼20, respectively). CFD simulations for 17 selected patients revealed a trend of increasing HFD toward the right pulmonary artery, with median splits of …

Ten Practical Tips For A Successful Presentation At An Infectious Disease Clinical Case Conference, Takahiro Matsuo, Pablo C Okhuysen, Ben J Barnett

Faculty, Staff and Student Publications

This mini-review provides 10 practical tips for infectious disease trainees presenting at clinical case conferences. These tips, grounded in principles from education theory, aim to enhance the effectiveness of case presentations.

Green Human Resource Management System Development In Africa: A Systematic Literature Review, Jinghan Wang, Lijun Tang, Jinhua Zhang, Bong-Keun Choi, Christopher Phillips

Plymouth Business School

Green Human Resource Management (GHRM) has garnered widespread international attention, yet the GHRM practices implementation and the challenges they face in African organisations remain underexplored. Given that the majority of GHRM studies in the African context have been published over the past four years, there is a clear need for a systematic review of the literature on GHRM in this region. This review examines 23 studies to identify which GHRM topics have been explored in the African context and what theories and methodologies have been adopted in these studies. Drawing from the selected literature, a conceptual framework is established to …

An Exhibition And Protest Of Executions In Iran, Donna M. Hughes

Dignity: A Journal of Analysis of Exploitation and Violence

An exhibition and protest of executions in Iran was held in Washington, D.C. in June 2025. Portraits of 2000 men and women who were killed or executed in Iran since the 1980s were displayed on the National Mall in front of the Capitol. The Iranian Resistance estimates that 30,000 activists were massacred in one period in 1988. Executions of prisoners have continued steadily, making Iran the world’s leading executioner of men and women. In recent years, there has been a sharp escalation in the number of executions of prisoners. A United Nations Special Rapporteur reported that over 800 persons were …

Artificial Insights Or Historical Fidelity? Crafting An Ethical Framework For The Use Of Genai In The Restoration, Reconstruction And Recreation Of Movable Cultural Heritage, David Ocón, Chunzhi Yin, Jose Luna

Research Collection School of Social Sciences

This article explores the ethical considerations surrounding using Generative Artificial Intelligence (GenAI) in preserving movable cultural heritage, focusing specifically on its application in restoration, reconstruction, and recreation. While GenAI offers innovative methods for preserving and recreating cultural heritage, it also presents significant ethical challenges. The article reviews current studies on the role of GenAI in heritage preservation alongside relevant ethical guidelines and proposes a tailored ethical framework for its application in movable heritage. The framework addresses several critical ethical concerns, including cultural integrity and sensitivity, accuracy and authenticity, intellectual property rights, sustainability and social impact, and governance and ethical accountability. …

Diaspora By Another Name: The Making Of Refugees In Cold War China, Jiaqi M. Liu, Clare Xiaoqian Wan

Research Collection School of Social Sciences

By examining China’s refugee policies from 1949 to 1982, this article demonstrates how the Chinese state redefined “return” and “refugee” to serve shifting political objectives. While China is often perceived as a source, rather than a host, of asylum seekers, it hosted over 320,000 displaced migrants—primarily ethnic Chinese from Southeast Asia—during the Cold War. Through a systematic discourse analysis of 382 People’s Daily articles, we identify four state narratives—diaspora, diplomatic tool, ideological sanctuary, and legal duty—that structured how China labeled displaced migrants, interpreted their sentiments, and determined their settlement. These models evolved dynamically: from the 1950s to the late 1970s, …

Not Staying Regular?, Joshua Thong

Research Collection School of Social Sciences

Consider the following claims: 1. Rational credences are real-valued. 2. A rational agent is more confident in than in just in case appropriate set-theoretic relations between the relevant events and/or appropriate inequalities between her numerical credences, whether conditional or not, hold. 3. If a rational agent’s conditional credence in, given, is greater than her conditional credence in, given, then she is more confident in than in. 4. There are two distinct and particular ways of ordering the events in a lottery over the naturals, for each of which there exists a rational agent whose comparative confidence ordering corresponds to that …

Governing Migration, Producing Skills: Emigration And Education In The Philippines, Yasmin Y. Ortiga, Roderick. Galam

Research Collection School of Social Sciences

This article examines skill as an integral yet understudied aspect of emigration governance. To date, migration studies have mainly focused on how the demand for migrant skills drive people's movements across borders, shaping the conditions for entry into popular destinations in the West. In contrast, less is known as to how skills also shape the way governments manage emigration, pushing would-be migrants to acquire certain capacities well before they leave their countries of origin. Drawing from the case of the Philippines, this article discusses how state agencies have used skills training to dominate specific markets for migrant professionals and demand …

Stockpiling, Forecasting And Protecting Skills: Skilling As Technique Of Preparedness In Times Of Crises, Rebecca Ye, Yasmin Y. Ortiga

Research Collection School of Social Sciences

In this comparative and situational analysis, we examine how nation-states use skilling as a technique of preparedness during crisis moments. By analysing two strategically selected country cases, Singapore and Sweden, during a critical phase of a global pandemic, we identify three techniques: stockpiling, forecasting, and protecting skills, and how these were enacted as a means to perform preparedness. Stockpiling skills was observed to take place as a rapid response; forecasting skills was a technique enacted with a view on the longer-term horizon and protecting skills was mobilised as a short-term future technique, where boundaries were assembled around skilling. While there …

Religious Beliefs, Cooperation, And Evolutionary Mechanisms, Nicole Fellice Ko, Norman P. Li

Research Collection School of Social Sciences

Religion is an organized system of spiritual beliefs, practices, and rituals that often involve a sense of the divine (Schilbrack, 2022). An evolutionary mechanism is an evolved set of traits that interpret environmental inputs and generate behavioral responses that enhance survival or reproductive success (Li et al., 2018). Cooperation refers to the act of individuals or groups working together to achieve a shared goal or mutual benefit (Alós-Ferrer & Garagnani, 2020).

The Experience Of Codependency In Young Adult Romantic Relationships, Amanda S. Soares

Undergraduate Theses and Capstone Projects

This qualitative study used Interpretative Phenomenological Analysis (IPA) to explore the lived experiences of codependency among four young adults (ages 21–24) who had recently exited a codependent romantic relationship. Through in-depth interviews, themes around emotional enmeshment, identity loss, boundary erosion, emotional suppression, and healing were found. Findings indicate that early attachment patterns, trauma, and socialization intersect with emotional vulnerability and self-worth to create conditions ripe for codependent dynamics. Participants describe both the psychological toll of these relationships and the personal growth that followed. These insights contribute to the limited literature on young adult codependency and may inform prevention and intervention …

Manufactured Superiority: The War On Terror, United States Dominated Media, And The Global Implications Of American Exceptionalism, Ayan Mohamed

Undergraduate Theses and Capstone Projects

This research examines American exceptionalism and its effects on the global perception of the United States, specifically how it shapes international narratives, marginalizes alternative perspectives, and reinforces a ruling American worldview that inhibits effective engagement and cross-cultural dialogue. The study will focus on two key areas: U.S. military interventions and media representation. First, it will analyze the War on Terror in Afghanistan and Iraq (2001–2021), assessing how U.S.-enforced destabilization in the region perpetuates hegemonic control. Second, it will investigate U.S.-backed, Israel-led Palestinian erasure as a case study of interventionism that positions the U.S. as the self-designated enforcer of global order. …

Novel Validation Of Hdr Brachy Therapy Dosimetry For Cervical Cancer Using Egs_Brachy Monte Carlo Simulations: A Comparative Analysis With Oncentra Treatment Planning System., Duong Thanh Tai, Nguyen Thi Anh Thu, Tran Thien Thanh, Pham Anh Tuan, Marc J P Chamberland, Peter Sandwall, David Bradley, James C L Chow

Oncology Articles

PURPOSE: This study aims to validate HDR brachytherapy dosimetry for cervical cancer patients utilizing the egs_brachy Monte Carlo (MC) simulation.

METHODS: Three cervical cancer patients treated with

RESULTS: TPS-calculated doses were greater than those obtained from MC simulations. For the CTV, the median percentage differences were 7.9% (Q1: 6.4%, Q3: 9.8%; range: 0.4%-10.4%) for D

CONCLUSION: CTV and critical organ doses calculated by the TPS were consistently greater than those obtained from MC simulations. This suggests that the TPS may overestimate dose distributions, especially in heterogeneous regions like the pelvis. These results emphasize the need for continued validation of TPS …

Exploring The Clinical Utility Of Neurofilament Light Chain Assays In Multiple Sclerosis Management., Amit Bar-Or, Jacqueline Nicholas, Jenny Feng, Francesca Sorrell, Mark Cascione

Neuroscience Articles

Multiple sclerosis (MS) is a chronic neuroinflammatory and neurodegenerative disease that affects nearly 1 million adults in the United States. Owing to its unpredictable disease course, diverse phenotypes, and an array of currently available disease-modifying therapies, a personalized approach to MS management is required. There is an unmet need to identify, validate, and incorporate prognostic, monitoring, and predictive biomarkers into routine clinical practice for MS. A mounting body of evidence supports the use of blood biomarkers, such as neurofilament light chain (NfL), in predicting disease activity and monitoring treatment response. Previous hurdles for the widespread use of NfL in the …

From Nation-Building To Collapse: Analyzing Afghanistan’S 2021 Fall And The Geopolitical Entropies Of U.S. Withdrawal, Arash Beidollahkhani, Edriss Rasa

Journal of Strategic Security

The collapse of the Afghan government in 2021 and the subsequent return of the Taliban marked a significant shift in contemporary geopolitics. This paper examines the political and social dynamics surrounding the U.S. and allied forces' withdrawal, focusing on the entropic forces that contributed to the breakdown of Afghanistan’s governance system. While Afghanistan has experienced recurrent governmental collapses, the post-2021 crisis highlights deeper structural challenges within both the geopolitical and domestic spheres. The research investigates the failure of the U.S.-backed Afghan government, established through two decades of nation-building efforts, and explores how the abrupt foreign withdrawal dismantled fragile political structures, …