Digital Commons Network^™

Clinical Pharmacist Assessment In Monitoring And Resolving The Adverse Drug Reaction In Bipolar Disorder Patients A Prospective, Observational Study At Tertiary Care Teaching Hospital, Parihar Ashish Singh, S. Ganachari Madiwalayya, V. Tekkalaki Bheemsain

Indian Journal of Health Sciences and Biomedical Research KLEU

BACKGROUND:

Adverse drug reaction (ADR) is a noxious, unintended effect of the drug which may occur due to pharmacotherapy of the disease. Bipolar disorder is a chronic mental illness represented by mania, depression and cyclic episode. The treatment of Bipolar disorder is lifelong. Hence, there are increased chances of ADRs.

METHODOLOGY:

An observational, prospective study was performed on 286 patients, to identify, monitor, and resolve the ADR with bipolar disorder patients. The patients aged 18–65 years of either gender or diagnosed with bipolar disorder were enrolled in the study. Patient-related data had been collected from the patient record; probability of …

Correlates Of Suicide And Temporal Variations In Subjects With Suicide Attempt, Bandna Gupta, Prashant Choudhary, Adarsh Tripathi, Anil Nischal, Manu Agarwal

Indian Journal of Health Sciences and Biomedical Research KLEU

BACKGROUND:

Suicide Attempt is a self-inflicted, potentially injurious behavior with a nonfatal outcome for which there was evidence of intent to die. Life changes could act as a stressor causing enhanced susceptibility for suicidal risk. Suicide is a complex public health problem due to interactive social, cultural, biological and psychological risk factors.

AIM:

To study suicide intent and it's association stressful life events in subjects with suicide attempt.

MATERIAL AND METHODS:

The study was cross-sectional, non-interventional study which included 102 patients. Semi-structured Performa including socio-demographic and clinical history details, Presumptive Stressful Life Events Scale (PSLES) [Singh

et al

., 1984] …

Utility Of C4d Deposits In Native Renal Diseases And Relation With Disease Progression, Sucheta Yadav, Atin Singhai, Suresh Babu, Vijay Kumar Singh, Anupam Wakhlu, Satyendra Sonkar, Bhupendra Pal Singh, Chanchal Rana

Indian Journal of Health Sciences and Biomedical Research KLEU

INTRODUCTION:

C4D is a well-known biomarker of complement cascade. The utility of C4D in identification of antibody-mediated rejection has been known since its incorporation in Banff classification in 2003. Recently, many researchers have turned their attention to C4D deposition in native renal diseases. The present study was done at our tertiary care center to adjudge the significance of C4D deposits in native renal diseases across Indian cohort of patients.

MATERIALS AND METHODS:

A retrospective study was done on fifty cases of native renal diseases and followed up at 6 months. C4D immunohistochemical analysis was performed on formalin-fixed paraffin-embedded renal tissue …

Evaluation Of Effect Of An Open Clinical Trial, Shubham Brajesh Gupta, Pradeep S. Shindhe, R. R. Hiremath

Indian Journal of Health Sciences and Biomedical Research KLEU

INTRODUCTION:

Constipation (

vibandha

) is a common clinical problem and symptoms of many diseases. It is not described as a separate disease in the classical text. Westerned life style, mental stress and diets are play major role in occurring in constipation (

vibnadha

). The diagnostic and evaluation of

vibandha

includes an proper history and investigation to exclude any other abnormalities and disease.

OBJECTIVE:

The objective of this study was to evaluate the effect of

kalyanaka kshara

in

vibandha

.

MATERIALS AND METHODS:

A clinical trial was conducted on a group of 30 patients diagnosed with the help of …

Design, Synthesis, And Biological Evaluation Of Novel Diclofenac Analogs As Promising Anti-Inflammatory Agents, Manjula K. Chikkamath, Girish A. Hampannavar, Mahesh B. Palkar

Indian Journal of Health Sciences and Biomedical Research KLEU

INTRODUCTION:

Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used as analgesics and antipyretics in the treatment of pain, fever, and rheumatoid arthritis. Major side effect with treatment of NSAIDs is gastric irritation. 1,3,4-thiadiazole is an imperative scaffold since several of these derivatives are known to be associated with multiple biological activities such as anti-inflammatory, antibacterial, anti-cancer, anti-tubercular, and immunosuppressive. Literature survey reveals that certain compounds bearing this nucleus possess significant anti-inflammatory activity with reduced ulcerogenic effect.

MATERIALS AND METHODS:

In the present research work, we have synthesized thirteen 2-(2-[2,6-dichlorophenylamino] phenyl) acetohydrazide derivatives (4a–4m) and four 2,6-dichloro-

N

-(2-[6-phenylimidazo[2,1-b][1,3,4]thiadiazol-yl] methyl] phenyl) benzenamine …

Excessive Gestational Weight Retention And Weight Gain In Postpartum Perception Of Women, Thilagavathy Ganapathy

Indian Journal of Health Sciences and Biomedical Research KLEU

CONTEXT:

Childbearing women are the second victims for significant gestational weight retention and weight gain during reproductive years. There may be unique reasons to weight management in this period.

AIM:

To explore what women perceive as reasons for their excessive gestational weight retention and weight gain in the postpartum period.

METHODS:

By purposive sampling,

n

= 200 low-risk postnatal women less than a year of postpartum were recruited and their perceived reasons for excessive gestational weight retention and weight gain in the postpartum period were assessed.

RESULTS:

Participants perceived lowered physical activity, sedentary lifestyle behavior, lack of knowledge, misconceptions that …

An Empirical Understanding On The Concept Of, Govardhan Belaguli, H. P. Savitha

Indian Journal of Health Sciences and Biomedical Research KLEU

Sattvavajaya Chikitsa

(SC) (

Ayurveda

Psychotherapy) is one among the brainchild concepts of

Acharya Charaka

(father of Indian medicine). In

Ayurveda

, SC is considered to be having the psychospiritual approach with a nonpharmacological treatment modality which solely deals on the mind and its related attributes. SC has 5 methodology, 2 principles, 3 dimensions, 3 psychotherapeutic domains, and 5 techniques. This psychotherapy helps in controlling

Manas

(mind) away from

Ahita Artha

(distractible, unwholesome objects/thoughts/perceptions). Withdrawal of the bothered mind from unwholesome objects is the prime focus of SC. Mainly focusing on the intelligence, consciousness, memory, and spiritual aspects of the …

Assessment Of Implementation Of The National Programme For The Prevention And Control Of Cancer, Diabetes, Cardiovascular Diseases, And Stroke At Subcenters Of Belagavi Taluka A Cross-Sectional Study, Vinayak H. Kashyap, M. S. Shivaswamy

Indian Journal of Health Sciences and Biomedical Research KLEU

CONTEXT:

Mortality due to noncommunicable diseases (NCDs) has increased worldwide and, according to the World Health Organization report in 2012, 68% of mortality was due to NCDs. In India, deaths due to NCDs in 2008 were 5.3 million. A rapid health transition is being experienced in India with a rising burden of NCDs. The first point of contact of patients with health services is primary health-care (PHC) facilities, which are the most appropriate places for patient screening and early detection. The National Programme for Prevention and Control of Cancer, Diabetes, Cardiovascular diseases and Stroke (NPCDCS) was launched in 2010 in …

Predatory Journals A Threat To Evidence-Based Science, Mamta Choudhary, Nancy Kurien

Indian Journal of Health Sciences and Biomedical Research KLEU

One of the latest threats emerged to the integrity of academic publishing is predatory journals. These journals have paved the way for low-quality articles by exploiting gold open-access publishing, threatening standards of evidence-based science. These journals lack the authentication of legitimate scholarly journals such as peer review, editing, editorial boards, editorial offices, and other editorial standards, imposing a number of new ethical issues in publishing research papers. Some of these claim to assess submissions within 72 h and digitally publish them on acceptance and receipt of the fee, showing their only motivation of procurement of evaluation and publication fees. While …

Do Noise Stress Impact To Addiction?, Sundareswaran Lognathan, Arbind Kumar Choudhary, Kuppusamy Mahesh Kumar

Indian Journal of Health Sciences and Biomedical Research KLEU

Numerous studies have illustrated the impact of stress on addiction, its development, relapse vulnerability, and the dopamine mechanism. However, various studies on noise exposures as a stressor had been done, which could alter the hypothalamic–pituitary–adrenal (HPA) axis. Noise exposure harmful effect and changes in the individual's health was at least consideration and were less noticed. This review elucidates the facts and consequences of noise exposure toward mesolimbic dopamine circuitry perceptible in addiction. Further, this review generates greater attention and awareness among people toward noise exposure influence on addiction and its relation with dopamine. The noise stress may act as a …

Trauma Center Is The Need Of The Hour, R. B. Nerli, Shridhar C. Ghagane

Indian Journal of Health Sciences and Biomedical Research KLEU

No abstract provided.

Radiographic Findings In Adults With Chronic Cough In Nigeria, Falmata Audu Gubio, Ahmed Abubakar, Alhaji Modu Ali

Indian Journal of Health Sciences and Biomedical Research KLEU

BACKGROUND:

A cough is the major functional mechanism which is responsible for the clearance of secretions from the respiratory tract and serves as an important defense mechanism, and chest X-ray is the commonly indicated examination in this category of patients for possible diagnosis and treatment.

AIMS:

This study aimed at evaluating the spectrum of findings among patients presented with a chronic cough in the tropics.

MATERIALS AND METHODS:

A prospective study design was used to obtain data over a period of 3 months (March–May 2018). Adult patients aged 18 years and above who presented to the department with indication of …

A Rare Variety Of Pulmonary Blastoma A Case Report And Review Of Literature, L. Purnima Devi, Umesh Das, Rintu Marak, Jyoti Prasad Kalita, Yookarin Khongla, Baphirayne Wankhar, Ibanylla Meggsi Pala Rymbai

Indian Journal of Health Sciences and Biomedical Research KLEU

Pulmonary blastoma (PB) is a very rare primary lung neoplasm. Morphologically, they mimic fetal lung tissue before 4 months gestation. As monophasic variety is extremely rare, we have reported here a case of monophasic PB in a young adult patient who came with cough and hemoptysis for 4 months. On computed tomography scan of the chest, findings showed left upper lobe mass with few specks of calcification within the lesion. The patient underwent left upper lobectomy. The diagnosis was confirmed through histopathological examination with immunohistochemical evaluation. Because of its extreme rarity, we report this case with special interest to help …

Gnathic Osteosarcoma An Analysis Of A Single-Institutional Experience, Adebayo Aremu Ibikunle, Abdurrazaq Olanrewaju Taiwo, Ramat Oyebunmi Braimah, Kabir Abdullahi, Michael Adeyemi, Malami A. Usman

Indian Journal of Health Sciences and Biomedical Research KLEU

INTRODUCTION:

Osteosarcoma is an aggressive primary bone malignancy characterized by osteoid formation. It typically affects long bones, rarely affecting the jaws. OS of the jaws accounts has an estimated incidence of 0.7 per million. Reports of gnathic osteosarcoma from sub-Saharan Africa are few and to the best of our knowledge there is none from Northwestern Nigeria. This study aims to present our experience with gnathic osteosarcoma in our center.

MATERIALS AND METHODS:

A review of the records of patients managed on account of histologically diagnosed gnathic osteosarcoma at the Department of Dental and Maxillofacial Surgery, Usmanu Danfodiyo University Teaching Hospital, …

A Community-Based Study On Nasal Carriage Of Staphylococcus Aureus Among Healthy Schoolchildren And Its Antimicrobial Susceptibility Pattern, Ranjeeta, Sumati A. Hogade

Indian Journal of Health Sciences and Biomedical Research KLEU

BACKGROUND:

Invasive infections from

Staphylococcus aureus

are increasingly being encountered in healthy children. Nasal colonization of

S. aureus

is associated with increased risk for acquiring invasive disease. The objective of this study was to determine the prevalence and risk factors for

S. aureus

nasal colonization among a healthy pediatric population and to determine antibiotic susceptibilities of the

S. aureus

isolates.

MATERIALS AND METHODS:

Using a cross-sectional study design, a total of 468 children of age group 5–16 years from 15 different schools of urban Belgaum (Belagavi) located under Ramnagar Urban Health Centre of KLE University's Jawaharlal Nehru Medical College, India, …

Assisted Reproduction Technology Comparison Of Clinical Outcomes Between Day 3 And Day 5 Embryo Transfers, Lukman Omotayo Omokanye, Lateefat O. Saadu, Abdulwaheed W. Olajide Olatinwo, Sikiru Abayomi Biliaminu, Kabir Adekunle Durowade, Abubakar A. Panti, Ganiyu Adekunle Salaudeen

Indian Journal of Health Sciences and Biomedical Research KLEU

BACKGROUND:

Embryo transfer (ET) is a critical step in

in vitro

fertilization (IVF). Selecting the day of transfer for achieving the desired outcomes has been a great challenge.

AIMS AND OBJECTIVES:

The aim of this study was to compare the pregnancy rates of day 3 and day 5 ET in assisted conception.

MATERIALS AND METHODS:

This is a longitudinal prospective study of 122 eligible patients that underwent assisted reproduction program in our facility. All patients had controlled ovarian hyperstimulation using antagonist protocol. Patients with four or more zygotes were randomly allocated on day 1 to either day 3 or 5 …

Effect Of Dexmedetomidine On Hemodynamic Changes During Laryngoscopy, Intubation, And Perioperatively In Laparoscopic Surgeries, Suman Gupta, Shilpa Agarwal, D. D. Jethava, Bhanu Choudhary

Indian Journal of Health Sciences and Biomedical Research KLEU

INTRODUCTION:

Laryngoscopy and intubation lead to mechanical and chemical stimuli, resulting in hypertension and tachycardia. The pneumoperitineum and CO

2

insufflation with positional changes result in significant hemodynamic and respiratory changes. These sudden changes may lead to myocardial ischemia, pulmonary edema, and cerebral hemorrhage. Many modalities such as propofol infusion, beta-blocker, high-dose opioid, benzodiazepine, and vasodilators have been tried to obtund these changes. Dexmedetomidine is highly selective alpha-2 agonist, has been effective in attenuating sympathomimetic response during laryngoscopy, intubation as well as during laparoscopic surgeries.

OBJECTIVE:

In a randomized, prospective, double-blind, control study, we evaluate the safety and efficacy of …

A Cross-Sectional Study On Knowledge And Practices Regarding Birth Preparedness And Complication Readiness Among Pregnant Women Attending Antenatal Clinic At Kle's Dr. Prabhakar Kore Hospital And Medical Research Center, Belagavi, Iravva F. Padaguggari, M. S. Shivaswamy, Sanjeev B. Chougule

Indian Journal of Health Sciences and Biomedical Research KLEU

OBJECTIVE:

The objective is to assess the level of knowledge and practices regarding birth preparedness and complication readiness (BP and CR) among pregnant women.

MATERIALS AND METHODS:

The study was carried out in 2400-bedded tertiary care teaching hospital, Belagavi, over a period of 3 months from September to November 2017. A total of 384 pregnant women attending the antenatal clinic at the tertiary care teaching hospital were included in the study by purposive sampling. A descriptive approach was adopted, including collection of information from the pregnant women through a pretested and structured interview questionnaire and the data were analyzed using …

Awareness And Attitude Toward Household Poisons Among Medical And Nonmedical Students A Comparative Study, D. Priyanka, Gurudatta S. Pawar, Jayashree G. Pawar, Ashutosh Baliram Potdar

Indian Journal of Health Sciences and Biomedical Research KLEU

INTRODUCTION:

There are innumerable things we use in our household on day-to-day basis. Many things that we use at home from cleaning products to cosmetics are toxic when we are not careful about them.

OBJECTIVES:

The study is carried out to assess and to compare the awareness and attitude of medical and nonmedical students toward household poisons and to bring awareness among the students and general public about household poisons.

MATERIALS AND METHODS:

A questionnaire containing 40 questions were given to the study category of students (300 students, 150 medical and 150 nonmedical), tabulated, and analyzed using SPSS 17.

RESULTS: …

Influence Of Occupation And Hand Dominance On The Thickness Of Pronator Quadratus Muscle Among Apparently Healthy Volunteers In A Nigerian Population, Anthony Chukwuka Ugwu, Benjamin Efiong Udoh, Alhaji Modu Ali, Mohammed Yusuf Mohammed, Umar Abubakar, Mohammed Abba

Indian Journal of Health Sciences and Biomedical Research KLEU

OBJECTIVES:

The aim of this study was to sonographically measure and compare the pronator quadratus muscle thickness (PQMT) in apparently healthy volunteers between two occupational groups and to assess the influence of hand dominance on the PQMT.

METHODS:

A total of 180 apparently healthy volunteers were enrolled in the study. The volunteers were grouped into repetitive (90) and nonrepetitive (90) workgroups. They were scanned with a B-mode ultrasound machine and linear transducer.

RESULTS:

The mean PQMT was significantly higher (

P

< 0.05) in the repetitive workgroup than in nonrepetitive workgroups. Similarly, a significant difference in mean PQMT was observed between dominant and nondominant hands in the repetitive workgroups (

P

< 0.05).

CONCLUSION:

The mean PQMT among repetitive workgroup is significantly higher when compared with nonrepetitive workgroups in the study …

The Role Of Fundus Fluorescein Angiography In Classification And Diagnosis Of Macular Diseases A Hospital-Based Study, Sangameshwarayya Salimath, Shivanand B. Patil, Arvind L. Tenagi, Umesh Harakuni, S. C. Bubanale, B. K. Rekha

Indian Journal of Health Sciences and Biomedical Research KLEU

AIMS AND OBJECTIVES:

The aims and objectives of this study is to assess the role of fundus fluorescein angiography (FFA) in classification and diagnosis of macular diseases.

SETTING AND DESIGN:

This was an 1-year hospital-based study conducted at KLES, Dr. Prabhakar Kore Hospital, Belagavi, Karnataka.

METHODOLOGY:

The present study was conducted in the Department of Ophthalmology, KLES, Dr. Prabhakar Kore Hospital and Medical Research Centre, Belagavi, on 66 participants from January 1

st

, 2016 to December 31

st

, 2016.

METHODS:

An 1-year hospital-based study was conducted on 66 patients who attended the outpatient department. A detailed history was …

Human Immunodeficiency Virus-Associated Thrombocytopenia Profiling Hematological Changes In The Human Immunodeficiency Virus-Infected And Aids Patients, Unnati Pitale, Deivanayagi Muthusamy, Manish Verma, Pritish Chandra Pal, Humera Ayesha, Kalyan Murru, Mvr Ratnam, Abhishek Singh Nayyar

Indian Journal of Health Sciences and Biomedical Research KLEU

CONTEXT AND AIM:

AIDS is an acronym for acquired immunodeficiency syndrome caused by a retrovirus known as human immunodeficiency virus (HIV) which breaks down the body's immune system, leaving the patient vulnerable to a host of life-threatening opportunistic infections, neurological disorders, or unusual malignancies. According to estimates by the WHO and UNAIDS, 35 million people were living with HIV globally at the end of the year 2013. The first AIDS case in India was detected in the year 1986. Seldom studies have been conducted correlating CD4 cell counts and complete blood picture including platelet counts in HIV infected and AIDS …

A Study On Safe Driving Performance Using Biofeedback Therapy Among Drivers In Delhi, Neelima Chakrabarty, Kumar Sumit, Kamini Gupta

Indian Journal of Health Sciences and Biomedical Research KLEU

INTRODUCTION:

Biofeedback therapy is essential for releasing the stress, gain awareness, and to control over psychophysiological processes. The current study deals with the impact of biofeedback therapy on drivers by comparing the performances of drivers on “Decision Time” (DT) test before and after the use of biofeedback therapy.

METHODOLOGY:

For this study, as a special case 40 drivers from special protection group were selected for administering the decision time (DT) from “Vienna Test System” before and after applying biofeedback therapy with respiratory training.

RESULTS:

The results of this study reveal the beneficial effects of biofeedback in reducing negative effects, thereby …

Hyperhomocysteinemia And Vitamin B12 Deficiency As A Risk Factor For Ischemic Stroke A Case–Control Study From Northwestern India, Banshi Lal Kumawat, Chandra Mohan Sharma, Mohit J. Shah, Maulik A. Panchal

Indian Journal of Health Sciences and Biomedical Research KLEU

BACKGROUND:

Vitamin B12 (B12) deficiency, by virtue of causing hyperhomocysteinemia (HHC), may be implicated as an acquired risk factor of ischemic stroke (IS), which is also easily modifiable. There is a scarcity of data from India regarding the prevalence of B12 deficiency in IS patients.

OBJECTIVES:

The objective of this study is to explore the relationship between B12 and folate deficiency, HHC, and IS.

DESIGN:

The study was a case–control study.

MATERIALS AND METHODS:

Eighty cases of IS were compared with equal number of age- and sex-matched controls. Plasma total homocysteine (tHcy) level, serum B12, and folate levels were analyzed …

Extrapyramidal Movement Disorder?/Tourette Syndrome-Plus?, Prasad Mamidi, Kshama Gupta

Indian Journal of Health Sciences and Biomedical Research KLEU

Uraga

/

Sarpa

/

Bhujaga grahonmada

(UG) is one among the 18 types of

bhootonmada. Bhootonmada

denotes a category of psychiatric/neuropsychiatric conditions assumed to be caused by affliction of evil spirits (

bhuta

/graha). Till date, no studies have been conducted on UG and it is unexplored. The present study is focused on the better understanding of UG and its clinical applicability. UG is characterized by features of

Krodhanam

(aggressiveness/impulsivity),

Nishwasantam

(hyperventilation/anxiety/phobia),

Bhramantam

(agitation/restlessness/hyperactivity),

Trasyantam

(startle response/hyperekplexia/anxiety/phobia),

Raktaaksha

(red eyes/Kayser–Fleischer rings),

Stabdha drishtim

(prolonged staring/abnormal eye movements),

Jihwa

lolayantam/

Srikkinyau lihaan

(facial tics),

Sarpavat

prasarati/

Adhomukha shaayinam

(athetosis/chorea/motor tics/opisthotonus),

Chalam …

Probiotic Use In The Management Of Hypertension A New Era Of Therapeutic Management, Swapnil Purushottam Borse, Devendra Pratap Singh, Dilawar Upadhyay, Vipin Sharma, Manish A. Nivsarkar

Indian Journal of Health Sciences and Biomedical Research KLEU

Hypertension (HTN) has become a common chronic medical condition which affects ≥20% of adult population worldwide. HTN is assumed to be a major contributing factor for increasing complication of metabolic syndrome by adding one or more comorbidities such as heart disease, stroke, chronic renal failure, myocardial infarction, blindness, and dementia. HTN is also considered as a lifestyle disorder, and there are mainly two types of HTN, namely primary and secondary. Primary HTN is about 90%–95% of all cases of HTN and it is defined as high blood pressure due to genetic factors and nonspecific lifestyle, while secondary HTN is due …

The Promotion Conundrum Is It Time For Reform In Indian Dental Schools?, Vasanti Lagali-Jirge, Kamal Shigli

Indian Journal of Health Sciences and Biomedical Research KLEU

Promotion is an academic reward system for university faculty. The word promotion these days comes with mixed feelings. With our rapidly escalating population and increase in the number of dental schools and availability of specialists, faculty positions are rapidly getting saturated. In the early days, career advancements and promotion were primarily based on time. According to the current promotion guidelines, career advancement depends on performance, namely, publications, research, participation in other administrative responsibilities, and clinical work. However, publications seem to have a greater impact on the decision to promote. The Dental Council of India has devised a point system to …

Global Research Trends Of Literature In Sugar-Sweetened Beverages 2000–2016, Waleed M. Sweileh, Ansam F. Sawalha, Samah W. Al-Jabi, Saed H. Zyoud, Adham S. Abutaha

Indian Journal of Health Sciences and Biomedical Research KLEU

BACKGROUND:

Sugar-sweetened beverages (SSBs) are commonly used. The objective of this study was to analyze the quantity and quality of published literature on SSBs and present the results in a bibliometric format.

METHODOLOGY:

Scopus database was used to retrieve documents from 2000 to 2015. Annual growth of publications, collaborations, geographic distribution, visualization and mapping of collaboration, author analysis, and top-cited articles will be presented and discussed.

RESULTS:

The total number of worldwide publications on SSBs was 3345, published in 27 subject areas. More than half (58.30%) of the SSB publications were within the area of medicine. The number of publications …

World Suicide Prevention Day, R. B. Nerli, Shridhar C. Ghagane, Neeraj S. Dixit

Indian Journal of Health Sciences and Biomedical Research KLEU

No abstract provided.

Capecitabine-Induced Tongue Hyperpigmentation, Chaturbhuj Ramanand Agrawal, Silky Kothiwal

Indian Journal of Health Sciences and Biomedical Research KLEU

No abstract provided.