Digital Commons Network^™

Efficacy And Safety Of Oral Decitabine/Cedazuridine In The Chronic Myelomonocytic Leukaemia Subpopulations From Phase 2 And 3 Studies, Michael R Savona, Olatoyosi Odenike, Gail J Roboz, Harshad Amin, Amy E Dezern, Kim-Hien Dao, Bhavana Bhatnagar, Rena Buckstein, Brian Leber, Mary-Margaret Keating, Somedeb Ball, Aram Oganesian, Yuri Sano, Harold N Keer, Guillermo Garcia-Manero

Faculty, Staff and Student Publications

DNA methyltransferase inhibitors (DNMTis) are commonly used in treating chronic myelomonocytic leukaemia (CMML); however, data from prospective studies of DNMTis in CMML are limited. The present analysis evaluated the efficacy, safety and pharmacodynamics of the oral DNMTi decitabine/cedazuridine in the subset of patients with CMML from the phase 2 and 3 trials, which led to the approval of this agent for myelodysplastic syndromes and CMML in the United States and Canada. Potential prognostic factors also were analysed. In all, 34 patients with CMML were screened and 33 were treated. Most patients (76% [n = 25]) had myelodysplastic type-CMML and 77% …

Inhibition Of Methylthioadenosine Phosphorylase Protects From Experimental Acute Kidney Injury, Afaf Saliba, Yidong Chen, Jonathan W Nelson, Abhinav Vetcha, Wei Wei Wang, Nagarjunachary Ragi, Hamid Rabb, W Brian Reeves, Kumar Sharma

Faculty, Staff and Student Publications

Methylthioadenosine phosphorylase (MTAP) is a key enzyme in purine metabolism that may influence cellular responses to injury. We evaluated the effects of prophylactic MTAP inhibition in mouse models of ischemia-reperfusion and cisplatin-induced acute kidney injury (AKI). MTAP inhibition was confirmed by accumulation of methylthioadenosine (MTA). Treated mice showed reduced renal injury and decreased tubular damage. Transcriptomic analysis revealed protection from inflammatory and stress pathways, while maintaining oxidative phosphorylation, fatty acid metabolism, and epithelial integrity-related genes. Analysis of human single-cell RNA-seq data from the Kidney Precision Medicine Project indicated that MTAP is highly expressed in kidney injury marker-positive adaptive proximal tubule …

Tert Promoter Mutations And Survival Outcomes In Adult-Type Granulosa Cell Tumors, Allison L Brodsky, Alejandra Flores Legarreta, Bryan M Fellman, Deanna Glassman, Jeffrey How, Anil K Sood, David Gershenson, R Tyler Hillman

Faculty, Staff and Student Publications

Objectives: To evaluate survival outcomes among patients with adult-type granulosa cell tumors who have telomerase reverse transcriptase (TERT) promoter mutations.

Methods: This is a retrospective cohort study using the MD Anderson Rare Gynecologic Malignancy Registry. Patients with adult granulosa cell tumors who underwent molecular testing for TERT promoter and FOXL2 c.C402G mutations were included. We used descriptive statistics to compare demographic and clinical variables and estimated progression-free and overall survival with Kaplan-Meier curves. Cox proportional hazards regression and log-rank tests were employed for comparisons, with multivariable analyses adjusting for various factors.

Results: Among 70 patients, 28 (40%) had TERT+ tumors. …

Single-Cell Proteomic Analysis Reveals Multiple Myeloma Heterogeneity And The Dynamics Of The Tumor Immune Microenvironment In Precursor And Advanced States, Mohamed Kamal, Stephanie N Shishido, Jeremy Mason, Krina Patel, Elisabet E Manasanch, Peter Kuhn

Faculty, Staff and Student Publications

Multiple myeloma (MM) is an aggressive hematologic malignancy arising from plasma cell (PC) proliferation in the bone marrow, progressing from its precursor states MGUS and SMM. Despite therapeutic advances, MM remains incurable, underscoring the need for better risk stratification and early detection. Tumor heterogeneity and dynamic immune microenvironment changes drive progression, yet bulk analyses overlook rare subpopulations critical to disease evolution and resistance. This study employed multiplexed targeted proteomics to characterize bone marrow aspirates (BMA) from 22 patients to observe the change in the distribution of PCs and tumor immune microenvironment (TiME) cells across MM disease states and controls. Bone …

Nature-Inspired Metaheuristics For Optimizing Dose-Finding And Computationally Challenging Clinical Trial Designs, Weng Kee Wong, Yevgen Ryeznik, Oleksandr Sverdlov, Ping-Yang Chen, Xinying Fang, Shouhao Zhou

Faculty, Staff and Student Publications

Metaheuristics are commonly used in computer science and engineering to solve optimization problems, but their potential applications in clinical trial design have remained largely unexplored. This article provides a brief overview of metaheuristics and reviews their limited use in clinical trial settings. We focus on nature-inspired metaheuristics and apply one of its exemplary algorithms, the particle swarm optimization (PSO) algorithm, to find phase I/II designs that jointly consider toxicity and efficacy. As a specific application, we demonstrate the utility of PSO in designing optimal dose-finding studies to estimate the optimal biological dose (OBD) for a continuation-ratio model with four parameters …

Consensus Statement On The Prevention And Management Of Complications Of Fully Ablative Laser Resurfacing Of The Face, Bianca Y Kang, Joel L Cohen, Roy Geronemus, Suzanne L Kilmer, Edward Victor Ross, Jill S Waibel, Murad Alam, Macrene Alexiades, Kenneth A Arndt, Mathew Avram, Ashish C Bhatia, Brian Stuart Biesman, Jason D Bloom, A Jay Burns, Henry H L Chan, Catherine M Digiorgio, Jeffrey S Dover, Sam Fathizadeh, Sara C Esteves, Michael H Gold, Gerald N Goldberg, Merete Haedersdal, Elika Hoss, Omar A Ibrahimi, H Ray Jalian, Kristen M Kelly, Woraphong Manuskiatti, Lisa A Marks, Girish S Munavalli, Jason N Pozner, Chris W Robb, Anthony M Rossi, Nazanin Saedi, Peter R Shumaker, Kelly Stankiewicz, Molly Wanner, Douglas C Wu, Adam J Wulkan, Arisa Ortiz

Faculty, Staff and Student Publications

Objectives: To achieve consensus among expert laser surgeons on standards for the prevention and management of adverse events from fully ablative laser resurfacing of the face.

Materials and methods: Delphi study with two rounds of ratings and revisions until consensus was achieved. The draft set of statements was developed by a steering committee based on expert clinical experience. This was followed by two rounds of rating and revisions completed by an expert panel, then a virtual consensus meeting. In both rounds, respondents rated the draft statements on a 9-point Likert scale (1 = strongly disagree; 9 = strongly agree) and …

Celebrating The Fifth Edition Of The International Symposium On Fungal Stress – Isfus, A Decade After Its 2014 Debut, Alene Alder-Rangel, Amanda E A Rangel, Arturo Casadevall, Asiya Gusa, Chaoyang Xue, Chris Todd Hittinger, Consuelo Olivares-Yañez, Deborah Bell-Pedersen, Erica J Washington, Gerhard Braus, Guilhem Janbon, István Pócsi, Jason E Stajich, Jay C Dunlap, Joan W Bennett, Joseph Heitman, Ling Lu, Lucia Landi, Mari L Shinohara, Maurizio Del Poeta, Mavis A Acheampong, Mia R Maltz, Michael C Lorenz, Minou Nowrousian, N Louise Glass, Nichole A Broderick, Nicolás Pedrini, Nir Osherov, R Blake Billmyre, Sabrina Sarrocco, Salomé Leibundgut-Landmann, Vânia Aparecida Vicente, Xiaorong Lin, Xin-Qing Zhao, Yong-Sun Bahn, Zachary A Lewis, Drauzio E N Rangel

Faculty, Staff and Student Publications

The Fifth International Symposium on Fungal Stress (ISFUS) brought together in Brazil many of the leaders in the field of fungal stress responses, from fourteen countries, for four days of outstanding science ranging from basic research to studies with agricultural, medical, industrial, and environmental significance. In addition to the excellent oral and poster presentations, the Symposium organisers ensured that all participants had ample opportunity to engage, socialise, and network to exchange ideas and share research. The conference was enhanced by the world-class venue near Iguazu Falls, probably the greatest natural phenomenon in South America.

Sensing Freedom: Forensic Mental Health Ot & Service User Perspectives Of Sensory Processing & Occupational Participation, Elana Moore, Rosi Raine, Alison Warren, Karen Beaulieu

School of Health Professions

ABSTRACT SYNOPSIS:UK research explored forensic mental health occupational therapist and service user experiences of sensory processing and occupational participation. The incorporation of sensory processing information in occupation-focused practice is recommended.LEARNING OBJECTIVES:At the conclusion of this session, participants will be able to appreciate the utility of an experiential approach in occupational therapy research.At the conclusion of this session, participants will be able to consider how to incorporate sensory processing in occupation-focused practice.At the conclusion of this session, participants will be able understand the importance of addressing Transactionalism in occupational therapy.ABSTRACT:Purpose:The phenomenon of sensory processing is an everyday experience which occurs in …

Counteracting Cascades Challenge The Heterogeneity-Stability Relationship, Jordi Sola, Tom P. Fairchild, Matthew J. Perkins, James C. Bull, John N. Griffin

School of Biological and Marine Sciences

Spatial environmental heterogeneity is widely assumed to enhance ecological stability by promoting refugia, biodiversity and asynchrony. Yet, we lack field experiments testing this fundamental relationship and its underlying mechanisms in naturally assembled multitrophic systems. To address this gap, we monitored experimental substrates replicating topographic heterogeneity on a rocky shore over 3 years. Contrary to theory, heterogeneity showed no net effect on community stability due to four counteracting pathways. Heterogeneity increased stability by (i) providing refugia that enhanced population stability and (ii) boosting species richness, which promoted asynchrony. At the same time, it decreased stability by (iii) reducing a dominant non-native …

Does Midbrain Atrophy Distinguish Progressive Supranuclear Palsy From Frontotemporal Dementia?, Mauro César Quintão E Silva Cunningham, Sarah Teixeira Camargos, Vinícius Ribeiro Jeunon, Natalia Pessoa Rocha, Antônio Lúcio Teixeira, Thiago De Oliveira Maciel, Elisa De Paula França Resende, Francisco Eduardo Costa Cardoso, Paulo Caramelli, Leonardo Cruz De Souza

Faculty, Staff and Student Publications

Background: The diagnostic value of midbrain atrophy for distinguishing behavioral variant frontotemporal dementia (bvFTD) from progressive supranuclear palsy (PSP) is unclear.

Objective: To investigate whether measures of midbrain atrophy differentiate PSP from bvFTD.

Methods: We included four groups: healthy controls (n = 19), PSP-Richardson syndrome (n = 20), bvFTD (n = 19) and Parkinson's disease (PD; n = 12). The following quantitative and qualitative measures were calculated: Hummingbird sign rating scale [HBS-RS], global midbrain atrophy [GMA], midbrain area, midbrain/pons ratio, the Magnetic Resonance Parkinsonism Index (MRPI), the MRPI 2.0 and brainstem volume.

Results: Compared to controls, PSP and bvFTD had …

The Effect Of Maternal Antioxidant Vitamin Supplementation On Maternal And Cord Blood Adiponectin Concentrations, Jessica L Pippen, Paula Mcgee, James M Roberts, Leslie Myatt, Michael W Varner, Alan T N Tita, Ronald J Wapner, John M Thorp, Brian M Mercer, Beth A Plunkett, Sean C Blackwell, Anthony Sciscione, George R Saade

Faculty, Staff and Student Publications

Adiponectin is a hormone that modulates glucose regulation and fatty acid oxidation. Low adiponectin concentration has been associated with increased insulin resistance. Studies show a beneficial effect of vitamin E supplementation on insulin sensitivity. We aimed to investigate the association of prenatal antioxidant supplementation with increased adiponectin concentrations in pregnant participants and their newborn infants.Secondary analysis of a randomized control trial of prenatal vitamin C and E supplementation to prevent preeclampsia in low-risk nulliparous participants. Plasma of participants at time of randomization (9-16 weeks gestation) and delivery, and neonatal cord blood were analyzed by specific enzyme-linked immunosorbent assay for adiponectin …

Syncope As The First Clue To A Congenital Heart Defect

Faculty, Staff and Student Publications

No abstract provided.

The Microrna Mir-30a Blocks Adipose Tissue Fibrosis Accumulation In Obesity, Michael J Bolt, Sung Yun Jung, Kang Ho Kim, Kai Sun, Huaizhu Wu, Samuel Klein, Sean M Hartig

Faculty, Staff and Student Publications

White adipose tissue (WAT) fibrosis occurring in obesity contributes to the inflammatory and metabolic comorbidities of insulin resistance and type 2 diabetes, yet the mechanisms involved remain poorly understood. Here, we report a role for the broadly conserved miRNA miR-30a as a regulator of WAT fibrosis and systemic glucose metabolism. Mice modified to express miR-30a at elevated levels in adipose tissues maintain insulin sensitivity coupled with reduced fatty liver disease when fed a high-fat diet. These effects were attributable to cell-autonomous functions of miR-30a that potently increase expression of adipocyte-specific genes. Proteomic screening revealed miR-30a limits profibrotic programs in subcutaneous …

Warfare And Woodlands: Tracing Environmental And Military History In The Hürtgen Forest, Cedar Williams

All Graduate Theses and Dissertations, Fall 2023 to Present

This thesis explores what happens when war enters a forest. From 1944 to 1945, American and German forces fought a long, brutal battle in the Hürtgen Forest near Germany’s western border. The dark, wet, and heavily wooded terrain made the fighting unusually difficult. Soldiers struggled not just with enemy fire, but with freezing rain, deep mud, low visibility, and constant stress. The forest shaped how the battle unfolded and intensified its hardships.

But the war’s impact on the forest continued long after the soldiers left. Unexploded bombs and artillery shells littered the ground. During a heatwave in 1947, many of …

Principles And Practice In Pediatric Vascular Trauma: Part 1: Scope Of Problem, Team Structure, Multidisciplinary Dynamics, And Solutions, Matthew T Harting, Natalie A Drucker, Mary T Austin, Matthew R Greives, Bryan A Cotton, S Keisin Wang, Derrick P Williams, Joseph J Dubose, Charles S Cox

The Brown Foundation: Institute of Molecular Medicine

As of 2020, penetrating injuries became the leading cause of death among children and adolescents ages 1-19 in the United States. For the patients who initially survive and receive advanced medical care, vascular injuries are a significant cause of morbidity and additionally trigger notable trauma team angst. Moreover, penetrating injuries can lead to life-threatening hemorrhage and/or limb-threatening ischemia if not addressed promptly. Vascular injury management demands timely and unique expertise, particularly for pediatric patients. As the frequency of vascular injuries requiring operative management increases, it becomes clear that an ad hoc approach is not ideal. An integrated team would provide …

Transcriptomic Analysis Of Localized High-Risk Prostate Cancer Improves Prognostication And Identifies Benefit From Adding Docetaxel To Definitive Radiotherapy With Androgen Suppression In The Nrg Oncology/Rtog 0521 Phase 3 Trial, Ryan M Phillips, James A Proudfoot, Elai Davicioni, Yang Liu, Daniel E Spratt, Jeff M Simko, Robert B Den, Alan Pollack, Seth A Rosenthal, A Oliver Sartor, Christopher J Sweeney, Gerhardt Attard, Leslie Longoria, Samir Patel, Michael W Straza, Jason A Efstathiou, Amit B Shah, Karen E Hoffman, Joseph P Rodgers, Howard M Sandler, Felix Y Feng, Phuoc T Tran

Faculty, Staff and Student Publications

Background and objective: NRG/RTOG 0521 randomized men with high-risk localized prostate cancer (PC) to androgen suppression (AS) and definitive radiotherapy (RT) ± docetaxel-based chemotherapy (CT). The overall survival (OS) benefit with CT initially reported was lost on longer follow-up. The Decipher genomic classifier (GC) measures multiple transcripts relevant to docetaxel action. Basal/luminal differentiation portends differential response to AS and CT for high-risk localized and metastatic hormone-sensitive PC. We validated the Decipher GC in pretreatment biopsy samples for risk stratification and examined basal-luminal subtyping to predict docetaxel response.

Methods: Decipher GC scores and basal-luminal cellular subtypes were generated for specimens from …

Judicial Independence, The Separation Of Powers, And Criminal Investigations Of Judges, Benjamin Joshua Ong

Research Collection Yong Pung How School Of Law

In Haris Ibrahim [2023] 2 MLJ 296, the Federal Court of Malaysia discussed the legal limits to executive authorities’ powers to investigate judges on suspicion of crime. The case is a rare contribution to the jurisprudence on judges’ criminal liability at common law, as well as a case study in the challenges of reconciling judicial independence with other principles of the constitutional framework and other actors’ roles therein. The Court held that the implied constitutional principle of judicial independence requires that executive authorities follow a “set of protocols” (which the Court formulated) when investigating sitting judges. This was not wrong …

I See Sick People: Beliefs About Sensory Detection Of Infectious Disease Are Largely Consistent Across Cultures, Joshua M. Ackerman, Theodore Samore, Daniel M. T. Fessler, Norman P. Li, Et Al

Research Collection School of Social Sciences

Identifying cues to contagious disease is critical for effectively tracking and defending against interpersonal infection threats. People hold lay beliefs about the types of sensory information most relevant for identifying whether others are sick with transmissible illnesses. Are these beliefs universal, or do they vary along cultural and ecological dimensions? Participants in 58 countries (N = 19,217) judged how effective, and how likely they were to use, cues involving each of the five major sensory modalities in an imagined social interaction during a flu outbreak. Belief patterns were strongly consistent across countries (sight > audition > touch > smell > taste), suggesting a largely …

Socioeconomic Status Shapes Dyadic Interactions: Examining Behavioral And Physiologic Responses, Jacinth J. X. Tan, Tessa V. West, Wendy B. Mendes

Research Collection School of Social Sciences

With more opportunities for diverse interactions, little is known about how social interactions involving people of different socioeconomic status (SES) may unfold. We investigated social attunement patterns in dyadic interactions involving SES. Unacquainted individuals recruited from the community interacted with similar-or-different-SES partners in the lab (Ndyads = 130). Attunement was assessed throughout the interaction by examining physiological linkage—how much a person’s physiological change is predicted by another’s physiological change, over time. Overall, low-SES participants showed stronger physiological linkage—indicating greater attunement—to partners across SES. Participants also appeared more comfortable when interacting with low-SES partners. There were no SES differences in dominance …

A Lifespan Perspective On Positive Affect Fluctuations On Purpose In Life: Findings From A 9-Year Longitudinal Study, Jonathan L. Chia, Verity Y. Q. Lua, Andree Hartanto

Research Collection School of Social Sciences

Existing research has examined how static or average levels of positive affect (PA) influence purpose in life (PIL), but theoretical work suggests PA fluctuations may also play a role, potentially undermining PIL, especially in older adulthood. To this end, the present study examined the longitudinal association of PA fluctuations on PIL and the moderating role of age among 1,294 midlife and older adults in the United States, over a 9-year period (between 2004 and 2014). Results revealed a conditional effect of PA fluctuations on PIL – particularly among older individuals, and greater PA fluctuations were associated with a poorer sense …

Constraints Without Tears For Consequentialists, Matthew Hammerton

Research Collection School of Social Sciences

Agent-relative consequentialism uses the theoretical framework of consequentialism to capture the constraints favored by deontologists. Christopher Howard has recently argued that agent-relative consequentialism is implausible because it can only capture such constraints at the expense of getting other normative facts incorrect. In this reply, I argue that Howard’s objection to agent-relative consequentialism fails because it rests on faulty intuitions that arise from a misunderstanding of basic structural features of agent-relative consequentialism.

Longitudinal And Bidirectional Relations Between Problematic Social Media Use And Cognitive Failures, K. T. A. Sandeeshwara Kasturiratna, Andree Hartanto

Research Collection School of Social Sciences

With social media becoming increasingly pervasive in our daily lives, there have been heightened concerns that the distractions caused by compulsive and problematic social media use may lead to cognitive failures. While some preliminary work have explored the link between problematic social media use and cognitive functioning, most are cross-sectional, leaving it uncertain whether cognitive failures are a precursor or consequence of problematic social media use. To address this gap, the current study examines the bidirectional relationship between problematic social media use and cognitive failures. A sample of 252 young adults completed the Problematic Social Media Use Scale and the …

A General Bibliometric And Conceptual Structure Approach To Global Trend On Poverty Research In Islam Using Biblioshiny, Mohd Zaid Mustafar, Mohd Khairul Nizam Mohd Aziz, Dziauddin Sharif, Md Azzaat Ahsanie Lokman, Ashraff Bin Ruslan, Saiyidi Mat Roni

Research outputs 2022 to 2026

This study maps the intellectual landscape of research on poverty in Islam using a structured bibliometric approach with Biblioshiny (Bibliometrix) in RStudio. A Scopus search (TITLE-ABS-KEY “poverty” AND “Islam”) conducted on 1 September 2023 identified 279 English-language journal articles published between 1976 and 2023. The corpus spans 227 sources, 646 authors, and 10,262 cited references, with an annual growth rate of about 5%. Performance and science-mapping analyses reveal two “motor themes”—Islamic finance and healthcare/public health—while spiritually anchored constructs (e.g., maqasid, zakat governance, waqf, spiritual poverty) remain peripheral in co-occurrence and thematic maps. Citation patterns indicate higher field-normalized impact when studies …

Enhancing Gaas Solar Cell Efficiency Through Nanostructured Features: A Comprehensive Review Of Recent Advances, Challenges And Future Outlook, Mohammad Nur-E-Alam, Boon Kar Yap, Tiong Sieh Kiong, Mohammad Khairul Basher, Tarek Abedin, Mohammad Aminul Islam, Mohd Adib Ibrahim, Mayeen Uddin Khandaker, Narottam Das

Research outputs 2022 to 2026

This article aims to provide a synopsis of recent advances in the use of nanostructured features to augment the conversion efficiency of gallium arsenide (GaAs) solar cells. GaAs are a very well-known and highly advantageous material for solar cells because they possess an extraordinary bandgap (i.e., approximately 1.4 eV), wide spectral absorption coefficient, and favorable carrier mobility. Numerous studies have explored the use of nanostructures, such as antireflection (AR) nanofilms/nanocoatings, nanoparticles (NPs), and nanogratings (NG), to improve the conversion efficiency of GaAs-based solar cells. These structures are generally designed to enhance light transmission capacity and absorption while reducing light reflection …

Impact Of Biodegradation On The Mechanical And Fatigue Properties Of 3d-Printed Pla Bone Scaffolds, Hamed Bakhtiari, Alireza Nouri, Muhammad Aamir, Mohadeseh Najafi, Majid Tolouei-Rad

Research outputs 2022 to 2026

A proper degradation rate of bone scaffolds ensures optimal mechanical support and effective tissue regeneration. The present study examines the degradation effects of simulated body fluids (SBF) on the compressive and fatigue strength of 3D-printed PLA bone scaffolds. Scaffolds with varying surface-to-volume (S/V) ratios and identical porosity (60 %) were immersed in Hanks' solution for a maximum period of 30 days. Static and dynamic compression tests were performed at different immersion times to assess how S/V ratio influences the degradation process. CT images showed that scaffold pore structure remained interconnected after biodegradation, with no significant change in strut thickness or …

The Influence Of Surface Textural Properties And Adsorption Temperature On H2 Adsorption And Storage Performance Of Mil-88b(Fe) Mofs, Tawanda Matamba, Samira Sadeghi, Hussein Rasool Abid, Masoumeh Zargar, Alireza Keshavarz, Stefan Iglauer

Research outputs 2022 to 2026

To advance the establishment of a stable H2 economy we need to solve the issue regarding its storage. The physicochemical properties of Metal Organic Frameworks (MOFs) make them suitable for H2 storage. Therefore, here, we synthesized two Iron-based MOFs (12-MIL-88 B(Fe), 24-MIL-88 B(Fe) at different reaction times (12 h and 24 h), to investigate the relationship between adsorption temperature and pressure with the material's surface textural properties towards H2 storage (at 30 °C, 0 °C, −78.5 °C, and −196.15 °C and from vacuum pressure to 55 bar). Results showed that at 30 °C and 0 °C adsorption temperature, H2 adsorption …

Creating A New Climate Transition Politics? Reflections On A Real Deal For Australia, Amanda Tattersall, Katie Moore, Juliet Bennett, Christine Evans, Louise C. Johnson, Naomi Joy Godden, Dibya Shree Chhetry, Elise Ganley, Sally Fisher, Jaclyn Mccosker, Jade Wright, Liz Bonner, Helen Long, Noreen Nicholson

Research outputs 2022 to 2026

Economic responses to climate change, such as just transitions and the Green New Deal (GND), have helped shift climate policy debate to focus on the economic dimensions of climate change. Yet these approaches have also been limited; they have not always delivered, they have left some groups behind and at times have polarised affected constituencies. This article argues that a key reason for this is that these agendas have primarily involved imposing solutions on communities without activating people's participation in the perpetual cocreation of new social, political and economic solutions. Here, community and academic researchers reflect on the first five …

Endogenous Analgesia, Assessed Via Conditioned Pain Modulation, Is Not Different In People With Hip Osteoarthritis Compared To Controls: A Cross-Sectional Study, Myles C. Murphy, Molly Coventry, Ebonie K. Rio, Paola T. Chivers, Benedict Wand, Gordon Waddington, Andrea B. Mosler

Research outputs 2022 to 2026

Background: In people with knee osteoarthritis, measures of pain sensitivity have been demonstrated to relate to both pain severity and treatment outcomes, dependent on the type of pain sensitivity being tested. Objective: Quantify if differences in the pressure pain thresholds (PPT) or conditioned pain modulation (CPM) effect exist between people with hip osteoarthritis and age-matched controls without hip osteoarthritis. Methods: We performed a cross-sectional study across two geographic locations. PPTs at a local (hip) and remote (elbow) site were collected via a manual algometer. CPM was quantified using PPTs immediately prior to, and during ice water immersion of the hand …

Impact Of Geometrical Dimensions On The Shear Behaviour Of Uhpc Deep Beams Reinforced With Steel And Synthetic Fibres, Hossein Mirzaaghabeik, Nuha S. Mashaan, Sanjay Kumar Shukla

Research outputs 2022 to 2026

Ultra-high-performance concrete (UHPC) is recognized for its exceptional strength, durability, and versatility in engineering applications, making it a reliable composite in the construction industry. The incorporation of fibres into UHPC enhances its mechanical properties. Non-metallic fibres offer a promising alternative to steel fibres due to their resistance to corrosion. While much research has focused on the shear behaviour of UHPC reinforced with steel fibres, there is a notable gap in understanding the impact of non-metallic fibres. This study aims to address this gap by comparing the influence of synthetic fibres to steel fibres on the shear behaviour of UHPC through …

Incorporating Ecosystem Service Assessments Into Development Planning − Impact From A Dredging Project In South Australia On Seagrass, Sam Gaylard, Rachel Colella, Matt Nelson, Paul Lavery, Michelle Waycott

Research outputs 2022 to 2026

Major infrastructure development is required for economic development and to improve human well-being, however conflict exists between developers and the community. Environmental impact assessment (EIA) is used in over 100 countries to evaluate potential impacts of major developments across environment, economy, and social benchmarks. However, EIA has been criticized for a lack of transparency and accountability, lack of consultation or participation and inadequate science. An ecosystem service assessment (ESA) recognizes the links between the environment and the socio-economic environment, resulting in a more holistic evaluation of potential impacts and effective community consultation. Despite this, its inclusion within EIA's is rare. …