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Cholesterol Crystal Embolization Induced Kidney Disease, Shohan Pervaze, Shreya Mohandas, Pushkas Gopalan, Stephen A. Morse, Siddhartha Bajracharya, Landon A. Krone, Farshid Yazdi

School of Medicine Faculty Publications

Cholesterol crystal embolization (CCE) results from the release of cholesterol crystals from ruptured atherosclerotic plaques into circulation, resulting in the occlusion of small arteries and arterioles in various organs. Ischemia triggers a systemic inflammatory response resulting in vascular obstruction and organ dysfunction. Kidneys are often involved because of the proximity to the aorta and CCE in the kidneys can result in acute, sub-acute, or chronic kidney disease. There are many known risk factors for renal involvement of CCE, including iatrogenic and spontaneous causes. The pathophysiology of CCE includes complex pathways that lead to acute and chronic effects that can have …

The Impact Of Transformational Leadership On Leader Emotional Exhaustion And Patient Safety Culture: A Quantitative Study Devoted To Enhancing U.S. Healthcare Leaders, Katrina J. Wojciechowski

Education Doctoral

The United States (U.S.) healthcare system faces significant challenges, including high costs and disparities in access and quality of care. These issues were exacerbated by the COVID- 19 pandemic, which strained resources and staffing. Healthcare leaders must navigate the complexities of delivering care, managing costs, and ensuring high-quality, equitable healthcare services. Their role is crucial in transforming the healthcare system, driving change, and implementing innovations to enhance its effectiveness and efficiency. Equipping healthcare leaders with transformational leadership skills allows them to foster a culture of collaboration by inspiring and motivating teams to embrace change. This quantitative study aimed to (a) …

Development And Implementation Of An Ob/L&D Sbar Framework To Enhance Communication Between Obstetric Nurses And Anesthesia Providers: A Quality Improvement Initiative, Jenna E. Bigam, Laina J. Uzarski

Doctor of Nurse Anesthesia Practice (DNAP) Manuscripts

Effective communication between obstetric (OB) nurses and anesthesia providers is critical to ensure patient safety during epidural placements in labor and delivery (L&D) settings. At a large teaching hospital, communication gaps were identified when OB nurses requested anesthesia for epidural placements without consistently providing vital patient information. The lack of structured communication can result in important details being overlooked, which may lead to delays in care and potential patient harm. To address this, the SBAR (Situation, Background, Assessment, Recommendation) communication framework was implemented to standardize and improve information exchange. This Doctorate of Nurse Anesthesia Practice (DNAP) project aimed to enhance …

Prevalence And Risk Factors Of Gastroesophageal Reflux Disease Among Population Of Saudi Arabia: A Meta-Analysis, Waleed D. Khubzan, Dana O. Kaddah, Ola E. Alkhoshiban, Mirza H. Alkhater, Botool A. Alshahrani, Rama A. Alhatlani, Muntaha S. Alsulaimani, Dalal A. Elyas, Majed A. Almourgi

Saudi Medical Journal

ABSTRACT Objectives: To find how common gastroesophageal reflux disease (GERD) is in Saudi Arabia and to identify the main risk factors linked to it. Methods: We followed PRISMA guidelines and registered the study on PROSPERO (CRD42025637142). A full literature search was done across PubMed, MEDLINE, and Google Scholar up to December 2024. Two reviewers independently reviewed the results. We assessed the risk of bias using the JBI critical appraisal tool and evaluated potential reporting bias through Egger’s test. To determine the overall prevalence and key contributing risk factors, we conducted a meta-analysis utilizing a random-effects approach. We also did subgroup …

Green Growth Is A Pathway To Sustainable Development: An Empirical Study Of Saudi Green Initiative, Reema Gh. Alajmi

Journal of Economics and Administrative Sciences

For climate change adaptation and mitigation, a sustainable transition to green growth is essential. The aim of this study is to evaluate green growth indicators using three methods to assess the situation of green growth in Saudi Arabia. The vector error correction model (VECM) was used to estimate the relationship between electricity generation and carbon emissions (CO2), and then examine the mitigation scenario, followed by analysing Saudi green growth indicators versus Organisation for Economic Co-operation and Development (OECD) indicators. The results indicate carbon emissions are influenced by the GDP and electricity generation in Saudi Arabia. Environmental scenarios findings indicate that …

Exploring The Mediating Role Of Individual Performance In The Relationship Between Work-Life Balance And Attrition, Grace O. Leasure

Research Psychology Theses

Extensive research has established a relationship between work-life balance and employee attrition. However, limited attention has been given to the potential mediating role of individual performance within this dynamic. The present study aims to address this gap by examining whether individual performance mediates the relationship between work-life balance and attrition. It is hypothesized that higher work-life balance will be associated with lower attrition rates, partially explained by improved individual performance. Data will be collected via employee surveys and analyzed using mediation analysis. Anticipated results may provide organizations with a quantifiable, performance-based justification for investing in work-life balance initiatives.

Reflections Of Linguistic Experiences In A Borderland: Influences On Cultural Identity And Teacher Praxis, Iliana Cantu

Theses and Dissertations

This Autoethnographic dissertation uses autohistoria-teoria to critically analyze my lived curriculum as a Mexican-born raised in the borderland of the Rio Grande Valley. This research aims to understand the influence of my linguistic experiences on my cultural identity and teaching praxis within the same context. Drawing from Anzaldua’s (1987) concept of Borderlands as a contextual lens and Raciolinguistics as a theoretical framework, I examine and reflect on key linguistic experiences that have perpetuated colonizing linguistic practices rather than fostered linguistic diversity. Additionally, Culturally Linguistic Sustaining Pedagogy serves as a framework to critically analyze my teaching praxis in relation to my …

Occupational Therapy Educators’ Perceptions Of Preparedness To Teach Students Culturally Responsive Care For Diverse Patient Populations, Jack Ruelas

Theses and Dissertations

This phenomenological investigation examined occupational therapy faculty preparedness for teaching culturally responsive care to entry-level doctorate students in Texas. Despite Accreditation Council for Occupational Therapy Education (ACOTE) mandates requiring cultural competence education, significant gaps persist between regulatory requirements and faculty readiness to deliver such instruction effectively. The study explored three interrelated dimensions: (1) faculty perceptions of their preparedness to teach cultural competence, (2) institutional training and support mechanisms, and (3) pedagogical integration strategies for culturally responsive content.

Employing interpretive phenomenology grounded in Freire's critical pedagogy and Iwama's Kawa Model, this investigation utilized a two-phase data collection methodology with eleven faculty …

Development Of A Wearable Biosensor For Cortisol Detection In Human Sweat Utilizing Pani/Peo Polymer Blend And Nitrogen-Doped Graphene Quantum Dots, Cesar Sanchez

Theses and Dissertations

Since the development of the first biosensor in 1962, the evolution of commercially available wearable biosensors has been driven by an increasing consumer interest in real-time health tracking. However, challenges related to sensor sensitivity and cost have hindered progress. Deploying a novel approach, the biosensor integrates a blend of Polyaniline (PANi) and Polyethylene Oxide (PEO) along with Nitrogen-doped Graphene Quantum Dots (N-GQDs) to enhance sensitivity and electroactivity, crucial for cortisol detection. To optimize performance, three distinct synthesis methods for N-GQDs; hydrothermal, microwave, and hot plate synthesis were compared employing a bottom-up approach utilizing citric acid (CA) as the primary reactant …

Low-Dimensional Learning For Remaining Useful Life Prediction Of Batteries Operating Under Various Environments, Rodrigo Benavides

Theses and Dissertations

In reliability, we typically define the standard operating conditions under which a component operates. However, the differences in battery operating conditions cause variability in the degradation patterns of identically manufactured batteries, rendering remaining useful life prediction a major challenge. To aid this task, several sensors are utilized to monitor battery state-of-health. However, traditional prognostics algorithms do not scale well to the volume of data generated. Furthermore, several authors do not explicitly consider operating environments in their prediction models. Therefore, we present a high-dimensional data analytics framework that integrates operating environment information for battery prognostics. This framework combines Multilinear Principal Component …

A Diminished Alliance: The Effects Of French American Relations On The Leadership Of Washington, Adams, And Jefferson 1789-1809, Eric Christopher Carlson

Theses and Dissertations

This research examines the relationship between the United States and France during the first three presidencies and how it influenced the leadership and decision-making of Washington, Adams, and Jefferson. Throughout the thesis, it is argued that the most critical developments in the United States during these presidencies were connected to diplomatic relations with the French along with each leaders own private, but often public, perceptions of the French. The two decades that these three leaders were in office witnessed significant transformation in U.S.-French relations, especially as the French Revolution spiraled into a full-scale European conflict that threatened American neutrality. In …

Arginine Vasotocin And Corticosterone In Nesting And Non-Nesting Loggerhead Sea Turtles In X’Cacel-X’Cacelito Sanctuary, Krista Blair Reed

Theses and Dissertations

Sea turtles exhibit distinct behaviors before and after egg laying, however, not all individuals successfully oviposit. Some females display disruptions in their typical nesting behavior, returning to the water without laying eggs, which is referred to as a non-nesting emergence (NNE). NNEs can be due to external disturbances on the beach, but why they occur is often unclear. Arginine vasotocin (AVT) is a neuropeptide involved in various physiological processes, including stimulating smooth muscle contraction of the oviduct to facilitate egg deposition in nesting sea turtles. On the other hand, corticosterone is the primary stress hormone in sea turtles and is …

Opa1-Mediated Mitochondrial Dynamics In Myogenic Differentiation Of C2c12 Myoblasts, Daniel Eloy Bazan

Theses and Dissertations

Mitochondria play a pivotal role in metabolic energy production, cellular signaling, and apoptosis. To carry out these key cellular roles, mitochondria dynamically balance their organization through opposing including fusion and fission processes. The balance between mitochondrial fusion and fission is regulated by key proteins such as OPA1 (optic atrophy 1) and OMA1 (overlapping activity with metalloprotease). More recently, mitochondria have been increasingly revealed to play key roles in cellular differentiation, where metabolic demands are reprogrammed. This study aims to elucidate the specific roles of OPA1 and OMA1 in the differentiation of C2C12 myoblast cells into myotubes.

Our data demonstrates that …

Computational Calculations On Zno (0001) And Zno (1010) Surfaces With And Without Pd Adatoms, Amit Aich

Theses and Dissertations

In this research work, first-principles density functional theory (DFT) was used to study O-terminated, Zn-terminated ZnO (0001) surfaces and non-polar ZnO (1010) surfaces. Both clean surfaces and those with Pd or PdO adatoms were examined. Adsorption was considered at O, Zn and hollow sites. After structural relaxation, we analyzed the electronic, optical and adsorption properties. The O-terminated ZnO (0001) surface has a larger band gap of 0.76 eV and p-type conduction. The Zn-terminated surface has a smaller band gap of 0.15 eV and shows n-type behavior. Pd adsorption modifies ZnO’s electronic structure in a site-dependent manner. On O-terminated surfaces, it …

Phenotypic Plasticity In Response To Abiotic Factors In Silverleaf Nightshade (Solanum Elaeagnifolium), And The Effectiveness Of North American Lacebug (Gargaphia Arizonica Drake And Calvo) As A Biocontrol, Marco Andre Silguero

Theses and Dissertations

Silverleaf nightshade (Solanum elaeagnifolium) is a widespread invasive weed in South Texas and other arid regions, where it reduces crop productivity, competes with native vegetation, and resists conventional control methods. Its ability to thrive across different environments is linked to phenotypic plasticity, allowing it to adjust growth and physiology in response to light and water availability. In this thesis, I examine the role of plasticity in S. elaeagnifolium under field conditions and evaluate the potential of the North American lacebug (Gargaphia arizonica) as a biological control agent. Field observations were used to measure plant traits such as height, stem thickness, …

Gut Passage Time In Small Mammals: Influences Of Small Mammal Traits, Digesta Phase, And Particle Morphology, Noah G. Hale

Electronic Theses and Dissertations

Dispersal is crucial in maintaining healthy ecosystems, but little is known about mechanisms influencing fungal spore dispersal by animals. We aimed to develop a more mechanistic understanding of the influence of fungal spore traits and small mammal traits on gut retention time. We fed three species of small mammals (shrew, mouse, vole), which differ in gut morphologies, digestive strategies, and activity a combination of markers including: liquid digesta phase (CrEDTA), small particle (fungal spores with diverse morphologies), and large particles (glitter and beads, representing plant cells and seeds, respectively). We found that hindgut fermenters selectively retained the liquid markers, spores …

Climate Change Denial Messages As Post-Truth, David H. Kahl Jr., Ahmet Atay

Journal of Communication Pedagogy

Post-truth messages are hegemonic forms of communication intentionally designed to create false narratives that perpetuate power and marginalize others. These messages make differentiating fact from fiction difficult. Students are especially susceptible to believing and internalizing post-truth messages due to their high level of interaction with social media and the neoliberal period in which they have been raised. One type of post-truth message that has become especially prevalent is climate change denial messages that advance a neoliberal agenda. This article will apply tenets of critical communication pedagogy (CCP) as a means by which to recognize messages that deny climate change as …

Sarcoplasmic Reticulum-Mitochondria Microdomains: Hugging And Kissing In The Heart, Bong Sook Jhun, Jin O-Uchi, Brian Rhee, Ameneh Ahrari, Nathan Demichaelis, Kye-Im Jeon, David M. Booth, Shey-Shing Sheu

Center for Translational Medicine Faculty Papers

Endoplasmic reticulum (ER)-mitochondrial (ER-Mito) interface, termed mitochondrial-ER contacts (MERCs), plays significant roles in the maintenance of bioenergetics and basal cell functions via the exchange of lipids, Ca 2 þ , and reactive oxygen species (ROS) in various cell types/tissues. Genetic deletion of mitofusin 2 (Mfn2), one of the key components of ER-Mito tethering, in cardiomy- ocytes (CMs) in vivo revealed the importance of the microdomains between mitochondria and sarcoplasmic reticulum (SR), a dif- ferentiated form of ER in muscle cells, for maintaining normal mitochondrial Ca 2 þ (mtCa 2 þ ) handling and bioenergetics in the adult heart. However, key …

Maggot As A Bioconversion Agent Of Cow Blood Waste And Date Pulp Into Feed Raw Materials: A Chemical Profile Study, Imra Atun Helmi, Hidayati Nufus, Ikrima Ahdavia, Muhamad Farid, Ahmad Sjahriza

Chimica et Natura Acta

Cow blood waste and date residue become environmental problems if not appropriately managed. So far, there has yet to be any special management to handle the waste. On the other hand, cow blood waste and date pulp can be efficiently decomposed by maggots. This research was carried out to utilize organic waste as maggot cultivation by producing animal feed materials high in protein and fat, and to determine the best composition in the feed medium. Maggot feed treatment consisted of household organic waste as P0, mixed feed as P1, the ratio of cow blood waste to date pulp P2 (1:1), …

Effectiveness Of Magnetic Nanocomposites Modified With Reduced Graphene Oxide Derived From Spent Coffee Grounds For Pharmaceutical Waste Remediation, Raisya Fakhira Khairani, Faisha Nurqisthi, Sindhi Ika Nuari, Syifa Rahmalia Herwinta, Aqilla Irfa Muthia Rahma, Diana Rakhmawaty Eddy

Chimica et Natura Acta

The Covid-19 pandemic significantly inflluenced the growth of the pharmaceutical industry in Indonesia, leading to environmental challenges, particularly with the discharge of pharmaceutical wastewater. Traditional treatment methods, such as flocculation and coagulation, hav limitations as they produce large volumes of activated sludge. An alternative approach for remediating this wastewater is the use of magnetite nanocomposites modified with reduced graphene oxide. This material leverages the unique properties of reduced graphene oxide, enhancing the separation and transfer of electron-hole pairs generated in the photogeneration process and significantly reducing charge carrier recombination in the photocatalytic system. This study aims to determine the degradation …

Identifying The Diagnostic Challenges And Indicators Of Orthostatic Tremor: Patient Perspectives, Diego Torresrussotto

All Publications

Background: The diagnosis of orthostatic tremor (OT) is challenging because of its non-specific symptoms and a broad range of differential diagnosis, resulting in a complex and lengthy diagnostic journey.

Objective: The aim was to assess the diagnostic delay in OT and to identify key clinical indicators as reported by patients.

Methods: In 2019, the American OT community developed and distributed a web-based survey titled "Symptoms and Diagnosis of Orthostatic Tremor (OT)." The survey included questions on demographics, the diagnostic process, and symptomatology.

Results: An international cohort of 360 OT patients participated in the study, of which 147 with electromyography (EMG)-confirmed …

Multimedia Forensics: Identification And Verification Of Source Camera, Vehicle Speed Estimation, And Deepfakes Detection, Jiajun Jiang

Electrical & Computer Engineering Theses & Dissertations

This dissertation advances multimedia forensics by addressing three critical research areas that enhance the authenticity verification and analysis of digital media. Multimedia forensics, which encompasses techniques for examining images, videos, audio, and text, faces increasing challenges due to sophisticated editing tools and massive data volumes. In the first study, a fast source camera identification and verification method based on PRNU analysis is proposed for video forensic investigations. By integrating camera rolling and I-frame analysis, this approach achieves a processing speed improvement of at least 15 times over conventional frame-by-frame methods while reducing false positives. The second study focuses on vehicular …

Complex System Governance And Cyber Operations, Willie Gernard Mccallister

Engineering Management & Systems Engineering Theses & Dissertations

This dissertation examines the potential integration of Complex System Governance (CSG) within cybersecurity, emphasizing the development of a reference model for Cybersecurity Infrastructures. Traditional strategies for securing digital environments have struggled to address the intricate and dynamic layers inherent in modern cybersecurity systems. The purpose of this research is to explore the applicability of CSG as a framework to assess cybersecurity infrastructure using a case study research design. The research addresses two key questions: (1) How can the CSG reference model be adapted to explore cybersecurity infrastructure? (2) What results from CSG based exploration of cybersecurity infrastructure through a case …

Effects Of Sediment Composition On Spartina Alterniflora And Juncus Roemerianus Productivity In Coastal Virginia: A Thin-Layer Sediment Placement Experiment, Caitlin Hemphill

Biological Sciences Theses & Dissertations

Climate change poses a major threat to the health of estuaries and their coastal wetland systems. The Chesapeake Bay’s coastal salt marshes are at high risk of inundation due to sea-level rise and land subsidence. Restoration techniques for maintaining coastal marsh resistance to sea-level rise are being developed and refined, with thin layer placement (TLP) emerging as a feasible solution in many areas of the United States. Despite TLPs use across the country, additional research is needed on species-specific responses, sediment types, and geographically focused studies in the lower Chesapeake Bay. My research addresses these gaps by combining both greenhouse …

Practicing In The Laboratories Of Democracy: An Interpretive Phenomenological Analysis Of How Political Science Faculty Use Simulations With Community College Students, James Stewart Shifflett

STEMPS Theses & Dissertations

Political science faculty members have often used simulations to promote civic engagement and build political efficacy in students. However, the use of political simulations with community college students has not been studied as extensively as it has with their four-year counterparts. Through the interpretive phenomenological analysis (IPA) methodology, this study examined the experiences of nine political science faculty members who use simulations with community college students to understand how instructional designers might better support their civic engagement and design efforts. Faculty members who participated in the study use simulations as constructive social interactions; as comprehensive learning experiences integrating preparation, facilitation …

Inter-Cellular Forces Modulate Cell-Ecm Traction Forces, Zaria Booth

Mechanical & Aerospace Engineering Theses & Dissertations

Epithelial cells are among the most abundant cell types in the human body, making up sheets of epithelial tissues that cover the linings of organs and body cavities. Cellular adhesion and force transmission across epithelial tissues are crucial in maintaining tissue integrity and ensuring proper tissue regeneration. Defects in cellular force transmission have been found in various diseases, including cancer. Force transmission at cell-cell and cell-ECM junctions drive cell survival and development. It has been previously shown that changes in cell-ECM traction directly modulates forces at cell-cell contacts. In this study, we aim to determine the effects of perturbations in …

'Managed Hearts’ In Helper-Education: Gender Non-Binary Helper-Educators’ Experiences Of Emotional Labor, Jordan Pearce

Counseling & Human Services Theses & Dissertations

The unique experiences of people who identify with a gender beyond the binary paradigm dominant in the Global West are not well understood. The literature provides little insight into the experiences and perspectives of these individuals in a variety of contexts, including in their workplaces. As various social movements collide, they bring amplified attention to the mental health of marginalized communities and to workers, as well as the dynamics of modern work environments, and the specific needs of certain individuals doing certain types of work. The current study explored the experiences of gender non-binary individuals (GNI) working as helper-educators engaged …

Drivers And Consequences Of Changes In Nectar Microbiome Composition Across Spatial And Biological Scales, Daniel A. Barker

Electronic Theses and Dissertations

Microbial communities inhabiting floral nectar, known as the nectar microbiome, are important mediators of plant-pollinator interactions. However, the ecological and environmental factors that shape the composition of these microbial communities remain poorly understood. While previous studies have examined the effects of a few microbial groups, typically independent of one another, on one plant or pollinator species, this dissertation takes a wide-scale approach to explore how abiotic conditions and biotic interaction’s structure microbial communities within floral nectar. Furthermore, I also quantify how variation in microbial richness and identity influences pollinator behavior and plant reproductive success.

This dissertation shows that microbial abundance …

Exploring Factors Influencing Care And Outcome Among Stroke Patients In Tennessee, Omodele Agbejimi

Electronic Theses and Dissertations

Introduction: Stroke is the fifth leading cause of death in Tennessee. Socioeconomic variables influence the delivery of stroke treatment and its outcomes. Despite advances in acute stroke care, the burden of stroke keeps increasing. This study aimed to explore literature on factors contributing to stroke care and outcomes in the U.S., assess the determinants of stroke patients’ outcomes, and examine the geographical disparities in stroke hospitalization and stroke death rate and their association with stroke care accessibility in Tennessee.

Methods: A scoping review was conducted using socio-ecological models to explore literature on factors contributing to stroke care and outcomes. A …

The Intersection Of Appalachian Identity And Gambling Behavior, Noah S. Anderson

Electronic Theses and Dissertations

This study examined the relation between Appalachian identity and gambling behavior among students in central Appalachia (n = 395). One-way ANOVAs revealed no significant differences in engagement, F(2, 392) = 0.65, p = .523, or severity, F(2, 392) = 0.33, p = .718, across identification groups. Moderated regression showed that identity did not significantly moderate the engagement–severity relation (B = 0.073, p = .099), though engagement itself was a strong predictor of harm (B = 0.696, p < .001, R² = .521). Negative affect predicted both engagement (B = 0.074, p = .001) and severity (B = 0.069, p = .001), while identity remained non-significant. Logistic regression found that identity predicted gambling engagement (Exp(B) = 1.18, p = .034) only when controlling for severity. These findings relay the importance of empirical efforts in Appalachia and suggest that Appalachian identity may not be an independent risk factor in gambling behavior.