Digital Commons Network^™

Differential Roof Water Hazards And Comprehensive Utilization Of Mine Water In The Dongsheng Coalfield, Huang Haiyu, Ding Xiang, Liu Xi, Fan Jiangwei, Ji Zhuochen, Li Zhaoyang

Coal Geology & Exploration

Objective The Dongsheng coalfield exhibits various types of mine water hazards, complex water filling mechanisms, and high water inflow with high total dissolved solids (TDS) content in mining areas. These characteristics pose challenges to the comprehensive utilization of mine water, severely restricting the safe, green, and efficient coal mining in the coalfield. Methods This study aims to reveal the roof water filling characteristics of the Dongsheng coalfield and enhance the comprehensive utilization of mine water. Using methods including statistical analysis of drilling data, analytic hierarchy process, and hydrochemical tests, this study analyzed the strata, spatial distribution of aquifers, and the …

An Experimental Study On Seepage Characteristics And Grouting-Induced Permeability Reduction Of Burnt Rocks, Qian Ziwei, Tan Chunzhi, Sun Qiang, Wang Hai, Zhang Gailing

Coal Geology & Exploration

Background Burnt rocks represent special geobodies formed by the spontaneous combustion of coal seams. Their pore and fracture systems provide preferential spaces for groundwater occurrence and migration while also posing severe water hazard threats to the safe mining of adjacent coal seams. Methods To address this engineering challenge, this study systematically analyzed the void structures within burnt rocks using three-dimensional reconstruction technology. Through laboratory seepage and grouting experiments, this study revealed the seepage patterns and grouting-induced permeability mechanisms of typical burnt rock specimens. Results and Conclusions The burnt rock specimens contained highly developed pores and fractures, with the void structures …

Developmental Pattern Of Water Flowing Fractured Zones In The Soil-Bedrock-Type Overburden And Water-Controlled Mining Strategy Under A Super-Large Mining Height, Zhang Yujun, Hua Zhaolai, Song Yejie, Hu Haoyu, Li Jiawei

Coal Geology & Exploration

Background The heights of water flowing fractured zones represent a key concern in the prevention and control of water disasters occurring in mining face roofs and water resource protection of coal mines. Varying lithologies and structures of the overburden are identified as primary factors governing the height and characteristic differences of water flowing fractured zones. Methods Against the engineering background of a mining face with 10 m super-large mining height in the Caojiatan Coal Mine of Shaanxi Province, this study investigated the differences in the mining-induced responses of the soil-bedrock-type overburden using numerical simulations of stress-seepage coupling and measured heights …

Multi-Objective Allocation Optimization Model For Water Resources From A Coal Mine In The Inner Mongolia-Shaanxi Contiguous Area, Miao Hechao, Dong Shuning, Wang Hao, Yang Yuanyuan, Qiao Wei, Wang Xiaodong, Wang Dongqi, Fu Hongyang, Liu Yuting

Coal Geology & Exploration

Objective In China, as coal resource exploitation shifts gradually from eastern to western regions, coal bases in the western region play an increasingly notable foundational role in the basic energy supply in the national economy. However, due to its fragile ecosystems, the safe, efficient, and green coal exploitation of this region has long been challenged by the contradiction between the prevention and control of water hazards and the conservation of water resources. Therefore, advancing intelligent mine water control technology is identified as a crucial method to address the conflicts between coal mining and mine water in the western region. Additionally, …

Regularity And Mechanisms Of Water-Sand Inrushes Within Mining-Activated Faults, Zhang Shichuan, Huang Pu, Li Yangyang, Wang Chenggong, Wu Zhenhua

Coal Geology & Exploration

Background During underground coal mining, water-sand mixtures within faults may rush into mine floors. The water-sand inrushes are especially prominent under the conditions of high water-yield properties and loose filling structures in fault zones, severely threatening the safe mining of coal mines. Previous studies focus primarily on the impact of a single factor on inrushes. Hence, it is significant to systematical investigate the regularity of water-sand inrushes within faults under the combined effects of multiple factors. Methods Based on the fluid and granular mechanic theories, this study derived the instability criterion and flow formulas of water-sand mixtures. Using orthogonal experiments …

Design And Efficiency Assessment Of A Passive Treatment System For Acid Mine Drainage, Yan Ruiwen, Zhu Jun, Zhu Junhao, Lin Gang, Zhang Wanqiu, Jia Zenghua, Wang Wenming, Xi Furui

Coal Geology & Exploration

Background Acid mine drainage (AMD) refers to highly acidic, heavy metal-rich effluent generated from mining activities, potentially causing severe environmental contamination. Methods Focusing on the Lujiang alum mine in Anhui Province, this study established a systematic framework for the design and assessment of an integrated passive AMD treatment system using the Phreeqc and AMDTreat software. Based on a comprehensive analysis of the on-site hydrogeochemical characteristics (pH: 2.93‒3.06, Fe: 5.98‒42.52 mg/L, and Al: 18.87‒32.14 mg/L) and physical conditions (flow rate: 50‒96 m³/h, available area: about 50 000 m²), this study proposed a hybrid passive treatment system comprising …

Groundwater Rebound And Seepage Characteristics And Water Quality Evolution In A Sealed Mining Area In North China Type Coalfield, Yin Huiyong, Sun Dehui, Dong Fangying, Wang Fanhua, Zhang Lifeng, Wu Tao, Liu Chao, Zeng Yifan

Coal Geology & Exploration

Background The seepage field and water quality evolution associated with the groundwater rebound induced by the sealing of mining areas significantly affects the prevention and control of mine water hazards, as well as the recycling of water resources. Systematically elucidating the mechanisms underlying the seepage-hydrochemistry synergy of groundwater is recognized as a fundamental scientific issue for promoting the collaborative management and resource development of the water systems in mining areas. Methods Based on the engineering background of the sealed No.116 mining area in the Binhu Coal Mine, Zaozhuang, Shandong Province, this study investigated the groundwater rebound and seepage characteristics, along …

Conversion Relationships And Three-Dimensional Storage And Utilization Modes Of Four Water Resources In An Open-Pit Mining Area, Chen Tianci, Xu Zhimin, Sun Yajun, Fang Jie, Wang Qiangmin, Xiong Xiaofeng, Zhu Yuhao, Lu Zihan, Wan Fei

Coal Geology & Exploration

Background Open-pit coal mines in China are primarily distributed in arid and semi-arid regions such as Xinjiang and Inner Mongolia. However, the contradiction between coal mining and groundwater resource conservation is increasingly prominent in these regions. Specifically, a substantial amount of mine water inflow produced during coal mining tends to lead to the further loss of groundwater resources within the influence range of a mining area. Concurrently, the failure of efficient mine water storage intensifies the regional water shortage.Methods This study investigated a typical open-pit coal mine in eastern Inner Mongolia. Using methods such as field survey and sampling, …

Advances In Key Technologies For The Management, Restoration, Development, And Utilization Of Coal Mining Subsidence Areas, Meng Zhuanghan, Wang Yutao, Tian Yanzhe

Coal Geology & Exploration

Background Coal mining subsidence areas, formed by the exploitation of coal resources, have emerged as severe challenges to the construction of ecological civilization and the sustainable development of the social economy in China. Their management, restoration, development, and utilization play a significant role in ecological security, food security, and energy transformation. Methods This study aims to address the unresolved and emerging issues in the management of coal mining subsidence areas. Based on the core concepts of management, restoration, development, and utilization, this study developed a dual-level zoning basis system combining theories and reality. Accordingly, coal mining subsidence areas in China …

Unpacking Digital Transformation – Constructing A Framework Based On Industry Use Cases, Khawaja Asjad Saeed, Andrew William Green, Alison Brooke Hedrick

Faculty Articles

Based on industry use cases, we identify six distinct types of digital transformation (DT), each grounded in a specific concept or enabling technology. These DT types can be implemented individually or combined to drive transformation initiatives. While deploying a single DT type often focuses on improving operational efficiency or streamlining existing workflows, initiatives that combine multiple DT types tend to pursue more ambitious goals, such as the creation of new products, services, or business models. However, the complexity increases significantly with the integration of multiple DT types, as organizations must not only address behavioral changes but also overcome technical challenges …

Comparing Concussion Recovery Rates Over Time, Francesca Andronic Md, William Kane, Daniele Shollenberger Crnp, Mark Cipolle Md

Research Scholars

No abstract provided.

Impact Of Virtual Visits On Antibiotic Prescribing For Upper Respiratory Infections, Anna Mikulski, Jarrod W. Kile Rphd, Brooke Broczkowski Pharmd, Kathryn Zaffiri Mph, Eric Young Md

Research Scholars

No abstract provided.

Long Term Outcomes Of Dermal Substrate Treated Burns And Wounds, Sarvesh Senguttunvan, Sigrid A. Blome-Eberwein Md

Research Scholars

No abstract provided.

Engagement, Motivation, And Interest In K-12 Science Education, Neil T M Bailie

Masters Projects

Interest, motivation, and engagement amongst science students is declining. This decline is primarily due to a loss of interest, motivation, self-efficacy, and perceived utility value (Bathgate & Schunn, 2017; Britner, 2008; Kraft, 2017). With crucial topics such as climate change and the legitimacy of vaccines coming under scrutiny, it is vital for our society that we keep our secondary students actively engaged and motivated with the science that they are learning in the classroom (Kolenatý et al., 2024; Schlopsna & Scheersoi, 2024). The main goal of this project was to create a complete unit curriculum covering the topics of the …

Substitution And Complementarity Between Human And Artificial Intelligence: A Dynamic Capabilities View, Christopher Agyapong Siaw, Waqas Ali

Plymouth Business School

Purpose: This paper draws on the dynamic capabilities (DC) view to develop a conceptual framework that explicates the mechanisms through which human intelligence (HI) and artificial intelligence (AI) substitute and complement each other for organizational knowledge management (KM) while considering the role of ethics. Design/methodology/approach: This is a conceptual paper that draws on DC theory and integrates insights from the burgeoning literature on organizational AI adoption and application to develop a conceptual framework that explains the mechanisms through which HI and AI may substitute and complement each other for organizational KM to develop DC. Findings: The conceptual framework demonstrates that …

Preparation And Characterization Of Electrospun Pvdf-Based Nanocomposite Fibers For Energy Harvesting And Storage Applications, Ahmed Ramzy, Electrochemistry And Corrosion Laboratory, Physical Chemistry Department, National Research Centre, Dokki, Cairo, 12622, Egypt, Ahmed M. El-Mahalawy

Nanotechnology Research Centre

This study introduces the development of multifunctional electrospun polyvinylidene fluoride (PVDF) composite films doped with potassium octatitanate (KTO) for advanced energy applications. The research tackles key challenges in energy generation and storage through innovative material design and detailed characterization. Adding 0.2 wt% KTO to PVDF electrospun fibers resulted in a notable increase in crystallinity to 78.51 %, marking a significant enhancement in material properties. Structural analysis using X-ray diffraction and Fourier transform infrared spectroscopy confirmed optimal phase composition, while morphological features were verified through field emission scanning electron microscopy. The composite films showed exceptional electrochemical performance, with bulk electrolyte resistance …

Inhibition Of The Caveolin-1 Pathway Promotes Apoptosis And Overcomes Pan-Tyrosine Kinase Inhibitor Resistance In Hepatocellular Carcinoma, Tasnuva D. Kabir, Samuel Beck, Lisa M. Stuart, Ji Li, Rui Hou, Peiwen Liu, Shelby Margolius, Claire Kim, Yu Suk Choi, Edward R. Bastow, Dianne J. Beveridge, Lisa Spalding, Ziyi Li, Florent Ginhoux, Pierce Chow, Michael Phillips, Andrew D. Redfern, George C. Yeoh, Alistair Forrest, Andrew J. Woo, Ankur Sharma, Jacob George, Geoffrey Mccaughan, Peter Leedman

Research outputs 2022 to 2026

Resistance to multi-tyrosine kinase inhibitors (TKI) is a major clinical concern in advanced hepatocellular carcinoma (HCC). Herein, we aimed to uncover the mechanisms underlying pan-TKI resistance and to identify potential therapeutic targets. We used multiple TKI-resistant HCC cell lines to identify caveolin-1 (CAV1) as a key driver of therapeutic resistance. CAV1 downregulation induced apoptosis, inhibited metastasis and restored TKI sensitivity in both inherent and acquired TKI-resistant HCC cells. Mechanistically, in acquired TKI-resistant cells aberrant CAV1/STAT3/P70S6K signalling is required for their survival, motility, and invasiveness. CAV1 inhibition reduced expression of dormancy regulators E-cadherin, RAC1 and p21, enhanced cancer stemness markers, and …

The Relationship Between Hand Grip Strength And Cognitive Function In Middle-Aged And Elderly People In China: A Cross-Sectional Analysis Based On Charls Data, Haiwei Li, Jing Zhang, Peipei Cheng, Liwei Guo, Xuemei Sui M.D., M.P.H., Ph.D.

Faculty Publications

This study explores the relationship between hand grip strength (HGS) and cognitive function in China’s middle-aged and elderly population. We employed a cross-sectional design using data from 4535 participants aged ≥ 45 years from the 2015 China Health and Retirement Longitudinal Study national dataset. The relationships between HGS and various dimensions of cognitive function, as well as the association between HGS and cognitive impairment, were investigated using ordinary least squares regression models and logistic regression models. Dose–response relationships between HGS and cognitive impairment were modeled using restricted cubic spline curves. Subgroup and sensitivity analyses were performed to assess the robustness …

Twist And Snout: Head And Body Morphologies Determine Feeding Kinematics In Substrate-Biting Fishes, Tal Perevolotsky, Jacob M. Brotman-Krass, Yarden Ratner, Yael Avigad, Adam P. Summers, Cassandra M. Donatelli, Roi Holzman

Engineering Faculty Articles and Research

Synopsis

Across teleosts, feeding by biting substrate-attached prey has evolved multiple times and is associated with convergent morphologies that include a deep body and an elongated, tapered head. However, the functional role of these morphologies in substrate-biting fish is not established. Here, we tested the hypothesis that these morphologies function as control surfaces that affect feeding kinematics during biting. To test this hypothesis, we used simplified physical models of substrate-biting reef fish and examined the role of head, body, and fin morphology in determining feeding kinematics that facilitate the removal of substrate-attached prey. Models simulated the swift lateral movement of …

Distinct Clinicogenomic Features And Immunotherapy Associations In Pulmonary Sarcomatoid Carcinoma: A Multicenter Retrospective Study, Lingzhi Hong, Alessandro Di Federico, Bolun Liu, Alissa J Cooper, Joao V Alessi, Phoebe Clark, Waree Rinsurongkawong, Chingyi Young, Hui Li, Kang Qin, Muhammad Aminu, Valentina Santo, Yasir Elamin, Boris Sepesi, Jeff Lewis, Don L Gibbons, Ara A Vaporciyan, J Jack Lee, Xiuning Le, Jia Wu, Sinchita Roy-Chowdhuri, Mark J Routbort, P Andrew Futreal, John V Heymach, Mark M Awad, Adam J Schoenfeld, Jianjun Zhang, Biagio Ricciuti, Lei Deng, Natalie I Vokes

Faculty, Staff and Student Publications

Introduction: Pulmonary sarcomatoid carcinoma (PSC) is a rare NSCLC subtype with poor prognosis. Outcomes to immune checkpoint inhibitors (ICIs) and genomic features in PSC remain underexplored compared with other NSCLC subtypes.

Methods: Patients from three institutions and the National Cancer Database (NCDB) with metastatic NSCLC treated with ICI alone or with chemotherapy were identified. Clinicogenomics and treatment outcomes were compared across PSC, lung adenocarcinoma (LUAD), and lung squamous cell carcinoma (LUSC).

Results: We analyzed 4841 patients including 165 PSC cases treated with ICI-based therapy from three institutions and 201 PSC from NCDB. In MDACC, 65 (4.3%) were PSC, 1138 (75.1%) …

Human Ipsc-Based Breast Cancer Model Identifies S100p-Dependent Cancer Stemness Induced By Brca1 Mutation, Jingxin Liu, Cai Zhao, Jiahao Chen, Pengguihang Zeng, Qingjian Li, Ranran Dai, Xingqiang Lai, Wenqian Song, Jianing Chen, Xixi Zhu, Xinyi Liu, Jun Sun, Jia Wang, Peihang Fang, Tengfei Wang, Wenjie Chen, Diana Guallar, Nan Cao, Jianli Zhao, Shicheng Su, Andy Peng Xiang, Yi Arial Zeng, Jie Li, Junchao Cai, Dung-Fang Lee, Jinxin Bei, Yongliang Huo, Hai Hu, Shengbao Suo, Dong-Feng Huang, Jin Bai, Junjun Ding

Faculty, Staff and Student Publications

Breast cancer is the most common malignancy in females and remains the leading cause of cancer-related deaths for women worldwide. The cellular and molecular basis of breast tumorigenesis is not completely understood partly due to the lack of human research models which simulate the development of breast cancer. Here, we developed a method for generating functional mammary-like cells (MCs) from human-induced pluripotent stem cells (iPSCs). The iPSC-MCs closely resemble human primary MCs at cellular, transcriptional, and functional levels. Using this method, a breast cancer model was generated using patient-derived iPSCs harboring germline

Adaptive Bayesian Clinical Trials: The Past, Present, And Future Of Clinical Research, Donald A Berry

Faculty, Staff and Student Publications

Background/Objectives: Decision-analytic Bayesian approaches are ideally suited for designing clinical trials. They have been used increasingly over the last 30 years in developing medical devices and drugs. A prototype trial is a bandit problem in which treating participants is as important as treating patients in clinical practice after the trial.

Methods: This article chronicles the use of the Bayesian approach in clinical trials motivated by bandit problems. It provides a comprehensive historical and practical review of Bayesian adaptive trials, with a focus on bandit-inspired designs.

Results: The 20th century saw advances in Bayesian methodology involving computer simulation. In the …

Mixed Galerkin- Implicit Differences Methods For Solving Couple Nonlinear Parabolic System With Constant Coefficients, Wafaa Abd Ibrahim, Jamil A. Ali Al-Hawasy

Baghdad Science Journal

In this paper, the mixed Galerkin- implicit difference method (MGIFDM) is used to solve a couple of nonlinear systems of parabolic partial differential equations with constant coefficients which are abbreviated by (CNPSCC). At first the weak form of the CNPSCC is formulated and then it is discretized using the proposed method, the method mixes the Galerkin finite element method (GFEM) in space variables with the implicit finite difference method (IFDM) in time variables, so the method was named by MGIFDM. At any discrete time tj the method transforms the CNPSCC into a couple Galerkin nonlinear algebraic system (CGNAS), which is …

Guest Editorial: Making Gender Equality Visible In Judicial Selections At The European Court Of Justice, Laure Clément-Wilz, Fernanda G. Nicola

Scholarly Articles in Law Reviews & Journals

We begin this issue with a Guest Editorial by Laure Clement-Wilz and Fernanda Nicola, who invite reflection on the criteria for judicial selection at the European Court of Justice. They propose integrating gender parity as a soft criterion in the judicial selection process, thereby contributing to broader discussions on diversity in judicial appointments

Phase 1b/2 Study Evaluating Safety, Efficacy And Immune Effects Of Tlr9 Agonist Cavrotolimod With Anti-Pd-1 Antibodies Among Patients With Advanced Solid Tumors, Mohammed M Milhem, George Ansstas, Et Al.

2020-Current year OA Pubs

BACKGROUND: There is an unmet need for novel immunotherapies to overcome immune evasion in patients with advanced skin cancers resistant to programmed death (PD)-1 / PD-ligand 1 (PD-L1) blockade. Cavrotolimod is a novel spherical nucleic acid configuration of a toll-like receptor 9 agonist oligonucleotide, designed to trigger innate and adaptive immune responses to tumors.

PATIENTS AND METHODS: The safety, pharmacokinetics, pharmacodynamics and preliminary efficacy of intratumoral cavrotolimod, first dosed alone and then in combination with anti-PD-1 antibodies (pembrolizumab or cemiplimab), were assessed in a combined Phase 1b/2 dose escalation/dose expansion study in patients with advanced skin cancers, including melanoma, Merkel …

Pengaruh Rasa, Tekstur, Dan Visual Terhadap Willingness To Buy Produk Ayam Geprek Rempah, Diandra Srivania Irwandini, Hasyim Asyari

Jurnal Administrasi Bisnis Terapan

This study explicitly aims to determaine the influence os taset, texture, and visual aspects on consumer Willingness to Buy (WTB) the Ayam Geprek Rempah product. Using a quantitative approach, the research involved 25 respondents who met the criteria, namely having a habit of purchasing food priced between IDR 25,000 and IDR 35,000, ordering food online at least twice a week, having a preference for ayam geprek, and havingtried the Ayam Geprek Rempah product. The data used was secondary data, and the analysis was conducted using the non-parametric statistical test, the Wilcoxon Signed-Ranks Test. The results showed that the taste variable …

Does Educator Preparation Align With State Standards? A Factor Analysis Of Missouri’S First-Year Teacher Survey, Ximena Uribe-Zarain, Beth Kania-Gosche, Mark Hogrebe

Mid-Western Educational Researcher

First-Year Teacher Surveys (FYTS) are essential for evaluating teacher preparation programs (TPPs), providing crucial feedback from recent graduates about their training and readiness for real-world teaching. This study focuses on Missouri’s FYTS, utilizing Exploratory Factor Analysis (EFA) and Confirmatory Factor Analysis (CFA) to investigate the survey's factor structure and its alignment with the state's nine teaching standards. The study sample consisted of 1,424 first-year teachers who completed the FYTS during the 2023 academic year. EFA revealed eight distinct factors, largely corresponding to the original standards, while CFA results supported the multidimensional factor structure with significant item loadings. Although model fit …

A Qualitative Study Understanding The Effects Of Eye Movement Desensitization And Reprocessing In Equine Therapy, Linsey Adams, Tara Rava Zolnikov

People and Animals: The International Journal of Research and Practice

This qualitative descriptive study investigates the efficacy of EquiLateral™, an equine-assisted EMDR protocol, in treating PTSD. Amid increasing global cases of stress-related disorders, particularly in the United States, the study explores the experiences of current and former clients engaged in EquiLateral™ therapy with a licensed therapist. The absence of standardized procedures in equine-assisted therapy research has left a gap in understanding specific activities that effectively reduce PTSD symptoms. Through semi-structured interviews, the study captures participants’ experiences and perceptions, revealing transformative impacts of EquiLateral™ therapy on managing PTSD. Nine thematic findings emerged: life-changing, present moment, calmness, safety and trust, manageability, changed …

Creating Learning Bridges: Redesigning Homework Within The Framework Of Multiple Intelligences, Vasileios Zagkotas

Journal of Educational Research and Practice

The article explores the application of Howard Gardner’s theory of multiple intelligences to homework and the potential of this approach to enhance the educational experience. Through a pilot application in philological subjects in Greek secondary education, the article presents the Homework Toolkit for Cultivating Multiple Intelligences, which offers various activities adapted to different types of intelligence. The findings from the case study research indicated that applying multiple intelligence theory to homework design improved academic performance, responsibility, and student collaboration, while also enhancing critical thinking and creativity. The results indicate that designing homework based on multimodal learning can reform the learning …

Operator Information Quantities Of Semigroups Associated With Functions Of The Number Operator, Ryo Inayoshi, Kimiaki Saito

Journal of Stochastic Analysis

In this paper, we present recent developments on the operator information quantity acting on white noise functionals. In particular, we give a stochastic expression of the operator information quantity of a semigroup generated by some function of the number operator through a white noise delta distribution centered at an infinite dimensional Ornstein-Uhlenbeck process.