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Full-Text Articles in Entire DC Network
Precision And Papers (Research Newsletter) Jan-Jun 2026, Department Of Surgery
Precision And Papers (Research Newsletter) Jan-Jun 2026, Department Of Surgery
Department of Surgery Archives
- Message from Vice-chair Research
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Waterfront Ecologies: Coastal Resilience And Urbanization In Cali-Baja Region, Agniya Seliuzhytskaya
Waterfront Ecologies: Coastal Resilience And Urbanization In Cali-Baja Region, Agniya Seliuzhytskaya
McNair Summer Research Program
This research contributes to “Waterfront Ecologies,” a binational initiative addressing urbanization and climate change along the San Diego-Tijuana coastal area and watershed systems. By examining the threshold between land and water, this paper investigates the impacts of sea-level rise, coastal erosion, watershed contamination, and rapid urban development. The study employs a case-study methodology focused on coastal conditions within the Cali-Baja region. Through this framework, it reviews planning history, environmental reports, and past precedent studies. Methodologically, the project produces analytical drawings and comprehensive base maps that synthesize regional environmental systems, urban patterns, topography, hydrology, and infrastructure.
Preliminary findings reveal that post-colonial …
Outbound Tourism – A Cluster Analysis Of Indian Travellers Based On Travel Motivation And Preferences, Shweta Belwal, Rakesh Belwal, Zoe Morgan, Latifa Hamood Al Badi
Outbound Tourism – A Cluster Analysis Of Indian Travellers Based On Travel Motivation And Preferences, Shweta Belwal, Rakesh Belwal, Zoe Morgan, Latifa Hamood Al Badi
Plymouth Business School
PurposeThis study aims to explore the travel motivations and preferences of Indian outbound tourists, segmented by motivation and sociodemographic traits.Design/methodology/approachUsing a quantitative research approach, the study administered a structured questionnaire via SurveyMonkey to potential Indian outbound travellers. Exploratory factor analysis (EFA) was used to identify key motivational factors, followed by hierarchical and k-means cluster analyses to derive and validate traveller segments.FindingsThe EFA revealed a five-factor structure comprising culture and heritage; adventure and aquatic activities; business and luxury; affordability and ease; and spatial-cultural proximity. Cluster analysis confirmed four distinct tourist segments: global nature explorers; proximity-conscious discerning explorers; indifferent travellers; and budget-conscious …
Online Parent Group Intervention For Executive Function Skills For Autistic Children And Adolescents, Kathleen Clark
Online Parent Group Intervention For Executive Function Skills For Autistic Children And Adolescents, Kathleen Clark
Theses and Dissertations
Executive functioning (EF) skills deficits are prevalent among children and adolescents with autism spectrum disorder (autism) that impacts their academic functioning, social relationships, and families' quality of life. This study aimed to explore an online parent group intervention, to test effectiveness of a 6-week parenting intervention on parenting stress and child's executive functioning (EF) among autism families in rural Utah with limited access to traditional intervention resources. The participants were eight parents from six families of children and adolescents (8-15 years) with clinical diagnosis of autism spectrum disorder and appropriate language abilities for their age. The parents participated in weekly …
Exploring Licensed Clinical Social Workers’ Past Trauma And Current Practice: A Strengths-Based Perspective, Michael E. Conner
Exploring Licensed Clinical Social Workers’ Past Trauma And Current Practice: A Strengths-Based Perspective, Michael E. Conner
Walden Dissertations and Doctoral Studies
This qualitative study explored the lived experiences of licensed clinical social workers to examine how they manage, reinterpret, and integrate their childhood trauma into their professional clinical identities. Adverse childhood experiences among clinicians are often framed through a risk-based lens of burnout and impairment, leaving social work leaders without empirical models to support post-traumatic growth and workforce retention. The purpose of this study was to examine how clinicians leverage past adversity to inform contemporary practice. A basic qualitative design was used, with semistructured interviews conducted with 11 participants. Participant narratives were examined through the dual lenses of shattered assumptions theory …
Improving Implementation Of The Cmqcc Obstetric Hemorrhage Risk Assessment Tool To Improve Maternal Hemorrhage Response And Outcomes, Emily Hobbs, Karla Beiswenger
Improving Implementation Of The Cmqcc Obstetric Hemorrhage Risk Assessment Tool To Improve Maternal Hemorrhage Response And Outcomes, Emily Hobbs, Karla Beiswenger
Doctor of Nurse Anesthesia Practice (DNAP) Manuscripts
Abstract Background: Postpartum hemorrhage (PPH) remains a leading cause of preventable maternal morbidity and mortality in the United States, despite advances in obstetric care and the availability of evidence-based management strategies (American College of Obstetricians and Gynecologists [ACOG], 2017; Federspiel et al., 2023). Standardized tools, such as the California Maternal Quality Care Collaborative (CMQCC) Obstetric Hemorrhage Risk Assessment Tool, have been shown to improve early identification of at-risk patients and enhance team preparedness when consistently implemented (Main et al., 2017; CMQCC, 2022). However, variability in clinical utilization limits their effectiveness. Purpose: The purpose of this quality improvement project was to …
Walking Through History: Designing A Byu Women's History Walking Tour, Reese M. Rugg
Walking Through History: Designing A Byu Women's History Walking Tour, Reese M. Rugg
Undergraduate Honors Theses
This thesis appears in two parts. The first is an analysis where I present a brief literature review of women’s history and women in editing and publishing. I also discuss the creation process and methods of applying design principles to a copyfitted manuscript of a BYU women’s history walking tour. The second is the copyfit 176-page manuscript and book cover, created in InDesign and Photoshop.
This project represents a continuation of recent efforts to highlight women who have built BYU in a more equitable way. The purpose of this project is to highlight the discrepancies in women’s archival history and …
Cultivating Intellectual Courage In Times Of Crisis: A Pedagogical Framework For The First-Year Classroom, Amanda E. Salmon
Cultivating Intellectual Courage In Times Of Crisis: A Pedagogical Framework For The First-Year Classroom, Amanda E. Salmon
Posters
No abstract provided.
Equitable Science Instruction For Diverse Learners: Differentiation With Consideration For Multilingual Students, Alicia Reyelts
Equitable Science Instruction For Diverse Learners: Differentiation With Consideration For Multilingual Students, Alicia Reyelts
Masters Projects
Multilingual learners (MLs) continue to experience persistent achievement gaps in science, often due to the linguistic demands of academic language and the limited availability of instructional supports within general education classrooms. As classrooms become increasingly diverse, science teachers require practical instructional resources that promote equitable access to rigorous, standards based learning while supporting students' language development. This master's project addresses this need through the development of a differentiated seventh-grade chemistry unit aligned with the Michigan Middle School Next Generation Science Standards (NGSS). The project is grounded in the principles of differentiated instruction (DI), drawing upon the work of Tomlinson as …
Upcycling Pomelo Peel And Eggplant Biomass Into Form-Stable Pcms, Xiao-Mei Yang, Guang-Zhong Yin
Upcycling Pomelo Peel And Eggplant Biomass Into Form-Stable Pcms, Xiao-Mei Yang, Guang-Zhong Yin
Artículos científicos
Eggplant tissue and pomelo peel waste were converted into lightweight biomass porous foams via freeze-drying and subsequently used as sustainable scaffolds for shape-stable PCMs. Paraffin (PA) and PEG 20 K were incorporated into the biomass-derived foams, where the naturally interconnected cellular structures provided abundant capillary channels for PCM uptake and confinement. The resulting composites achieved high PCM loadings of 81.44–93.50 wt%. The melting enthalpies of Eggplant-PA, Pomelo-PA, Eggplant-20K, and Pomelo-20K reached 169.31, 166.11, 155.76, and 143.56 J g⁻¹ , respectively, confirming their considerable latent heat storage capability. In particular, Eggplant-20K and Pomelo-20K exhibited high enthalpy efficiencies of 106.77% and 112.98%, …
Development Of A Structurally Distinct Topbp1 Inhibitor That Enhances Parp Blockade And Reverses Osimertinib Resistance, Fang-Tsyr Lin, Shwu-Jiuan Lin, Kang Liu, Yang Xiao, Lidija A Wilhelms Garan, Helena Folly-Kossi, Weei-Chin Lin
Development Of A Structurally Distinct Topbp1 Inhibitor That Enhances Parp Blockade And Reverses Osimertinib Resistance, Fang-Tsyr Lin, Shwu-Jiuan Lin, Kang Liu, Yang Xiao, Lidija A Wilhelms Garan, Helena Folly-Kossi, Weei-Chin Lin
Faculty, Staff and Students Publications
Therapeutic resistance remains a major challenge in cancer treatment, driven by compensatory signaling and stress response pathways that sustain tumor survival. Topoisomerase IIβ-binding protein 1 (TopBP1), a multifunctional scaffold protein with nine BRCT domains, integrates replication stress signaling with oncogenic networks and is frequently overexpressed in aggressive cancers. Its BRCT7/8 domains mediate critical interactions with E2F1, mutant p53, MIZ1, PLK1, and CIP2A, making TopBP1-BRCT7/8 an attractive therapeutic target. Using docking-guided screening and structure-activity relationship–driven optimization, we developed CS18 as a potent and selective BRCT7/8 inhibitor that disrupts oncogenic TopBP1 complexes without interfering with DNA replication. CS18 suppresses MYC transcriptional programs, …
The Exploration Of Pandemic Educational Equity Among Virginia Schools, James Edward Graves
The Exploration Of Pandemic Educational Equity Among Virginia Schools, James Edward Graves
Walden Dissertations and Doctoral Studies
The COVID-19 pandemic intensified existing educational inequities among marginalized student populations, prompting unprecedented federal investments through the Coronavirus, Aid, Relief, and Economic Security (CARES) Act to support educational continuity. Existing literature findings consistently demonstrated that collaborative leadership, equitable resource allocation, family engagement, and community partnerships improved educational continuity, which reduced learning disparities during the COVID-19 pandemic. Despite substantial resource allocations, limited research has examined parent perceptions regarding the equity and effectiveness of CARES Act-supported educational interventions. The purpose of this generic qualitative study was to explore Virginia high school parents' perceptions of pandemic educational equity, CARES Act financial disbursement strategies, …
Beauty Influencer Entrepreneur Marketing Strategies To Grow And Sustain Business And Improve Social Media Analytics, Kelsee Briana Barnes
Beauty Influencer Entrepreneur Marketing Strategies To Grow And Sustain Business And Improve Social Media Analytics, Kelsee Briana Barnes
Walden Dissertations and Doctoral Studies
The lack of marketing strategy knowledge can negatively affect beauty influencer entrepreneurs’ ability to fully leverage digital platforms to build sustainable businesses and strengthen their online presence. Beauty entrepreneurs are concerned, as the lack of marketing strategies can hinder the successful operation of social media platforms and may diminish online visibility. Grounded in Porter’s Five Forces framework, the purpose of this study was to explore the marketing strategies that beauty influencer entrepreneurs use to grow and sustain their social media platforms and improve social media analytics. The participants were eight beauty influencer entrepreneurs across various regions of the United States. …
Staff Education To Improve Evidence-Based Follow-Up For Patients With Severe Depression In An Outpatient Mental Health Clinic, Uzochiamaka Ndukwu
Staff Education To Improve Evidence-Based Follow-Up For Patients With Severe Depression In An Outpatient Mental Health Clinic, Uzochiamaka Ndukwu
Walden Dissertations and Doctoral Studies
The practice gap addressed in this Doctor of Nursing Practice (DNP) staff education project was the inconsistent documentation completion of evidence-based depression follow-up actions for patients with severe depression in an outpatient mental health clinic. National clinical practice guidelines recommend that patients with clinically significant depression receive timely, documented follow-up that includes appropriate treatment planning, behavioral health follow-up, medication management when clinically indicated, and repeat symptom reassessment. However, baseline chart audit findings demonstrated variability in documentation of these evidence-based follow-up actions. The practice-focused question was: In an outpatient mental health clinic, does a standardized staff education program on evidence-based depression …
Development And Implementation Of A Clinical Practice Guideline To Standardize Social Determinants Of Health Screening And Social Services Referrals In Primary Care, Patricia Pottinger
Development And Implementation Of A Clinical Practice Guideline To Standardize Social Determinants Of Health Screening And Social Services Referrals In Primary Care, Patricia Pottinger
Walden Dissertations and Doctoral Studies
Social determinants of health (SDOH) significantly influence health outcomes, yet many primary care organizations lack a standardized, evidence-based process for identifying patients' social needs and facilitating referrals to appropriate community resources. The purpose of this Doctor of Nursing Practice executive leadership project was to develop and implement a clinical practice guideline (CPG) to standardize SDOH screening and social services referrals in a primary care setting. The practice-focused question asked whether a CPG designed to standardize social services referrals would be approved by a panel of subject matter experts using the Appraisal of Guidelines for Research and Evaluation (AGREE) II instrument. …
Development Of Minimalist Trifunctional Building Blocks For Chemical Biology Probe Synthesis, Luke E. Bohrer
Development Of Minimalist Trifunctional Building Blocks For Chemical Biology Probe Synthesis, Luke E. Bohrer
Electronic Theses and Dissertations
The completion of the Human Genome Project in 2003 generated expectations that genomic information would accelerate the discovery of new protein drug targets and FDA-approved therapies. However, many small-molecule drug candidates continue to fail in clinical trials, and much of the human proteome remains undercharacterized in terms of structure, function, and disease relevance. Chemical tools are therefore essential for defining protein function, mapping protein interactions, and identifying disease-associated molecular mechanisms. Among these tools, small-molecule chemical probes provide a powerful strategy for connecting biological activity with target identification, functional analysis, and the development of effective therapies.
This dissertation describes the development …
Dialogic Communication Ethics As A Hopeful Response To Artificial Intelligence, Kristen Haldeman
Dialogic Communication Ethics As A Hopeful Response To Artificial Intelligence, Kristen Haldeman
Electronic Theses and Dissertations
Within the past five years, a new technology has dominated modern culture: artificial intelligence. With a multiplicity of ways to respond to this new environment, this dissertation situates a response to artificial intelligence by combining the media ecology and communication ethics perspectives. Media ecology explores historical roots and biases of technology to learn about their influence of humanity. A dialogic communication ethics seeks to find an opening for hope to emerge. Hope, grounded in the works of Jacques Ellul and the Christian tradition, offers a new rhetorical perspective by shifting focus away from technology and to our neighbor.
Race And Trauma: An Analysis Of Trauma Symptomology Across Diverse Youth Populations, Mara J. Niccoli
Race And Trauma: An Analysis Of Trauma Symptomology Across Diverse Youth Populations, Mara J. Niccoli
Electronic Theses and Dissertations
The adverse effects of trauma, particularly among youth who identify as Black, is a critical issue. This study investigated the relationship between race and trauma symptomology among children and adolescents who received weekly trauma therapy. With the use of clinical assessment data, this study sought to determine whether Black youth presented to treatment with higher trauma acuity than non-Black youth and if there were disparate outcomes in symptomology after treatment. The results indicated that on average, Black youth presented to treatment with lower trauma acuity than non-Black youth, and there were disparate outcomes in trauma symptomology between the two racial …
Between Care And Despair: An Existential Phenomenological Study Of Eco-Anxiety As Lived Experience, Conor H. Sukhdeo
Between Care And Despair: An Existential Phenomenological Study Of Eco-Anxiety As Lived Experience, Conor H. Sukhdeo
Electronic Theses and Dissertations
This dissertation explores the lived experience of eco-anxiety among young adults aware of the ongoing ecological crisis but not directly exposed to climate-related disasters. Grounded in the human science tradition, ecopsychology, and existential phenomenology, this study employed Scott Churchill’s (2022) approach to Existential Phenomenological Research (EPR) to deepen our understanding of the phenomenon of eco-anxiety. Four participants, residing in Pittsburgh and aged 18-25, produced written experiential descriptions and participated in open-ended phenomenological interviews. As outlined by EPR, this data was analyzed through meaning unit delineation, imaginative variation, phenomenological reduction, and structural synthesis to produce individual situated structures of eco-anxiety for …
Empathetic Political Communication As The Political Identity Of Female Legislators: A Phenomenological Study In The Surabaya City Dprd, Nurannafi Farni Syam Maella, Farida Farida, Herlina Harsono Njoto, Hamizah Sahharon, Vinna Amalia
Empathetic Political Communication As The Political Identity Of Female Legislators: A Phenomenological Study In The Surabaya City Dprd, Nurannafi Farni Syam Maella, Farida Farida, Herlina Harsono Njoto, Hamizah Sahharon, Vinna Amalia
JURNAL KOMUNIKASI INDONESIA
Politics has long been constructed as a masculine arena dominated by discourses of power, authority, and instrumental rationality. The presence of female legislators disrupts this hegemony by foregrounding empathetic modes of political communication that emphasize inclusivity, relational engagement, and responsiveness to social realities. These communicative practices not only contest dominant masculine norms in political discourse but also expand deliberative spaces and support the formulation of gender-responsive public policies. Accordingly, this study examines how female legislators in the Surabaya Legislative Council construct and enact empathetic political communication as a core expression of their political identity. Using a qualitative phenomenological approach, this …
Electrocatalytic Oxidation Of Ethylene Glycol To Glycolic Acid: From Mechanism And Catalyst Design To Emerging Neutral Electrolyte Systems, Man Zhang, Xue Li, Xinyu Peng, Lin Wang, Wenwen Chen, Yaoyue Yang
Electrocatalytic Oxidation Of Ethylene Glycol To Glycolic Acid: From Mechanism And Catalyst Design To Emerging Neutral Electrolyte Systems, Man Zhang, Xue Li, Xinyu Peng, Lin Wang, Wenwen Chen, Yaoyue Yang
Online First
Polyethylene terephthalate (PET) waste represents both an environmental burden and a loss of carbon resources. Alkaline depolymerization of PET yields terephthalic acid and ethylene glycol (EG). Electrocatalytic oxidation of EG to glycolic acid (GA), the monomer of biodegradable polyglycolic acid (PGA), offers a sustainable route driven by renewable electricity. However, the ethylene glycol oxidation reaction (EGOR) involves competing pathways toward C2 products (GA and oxalic acid) and C1 products (formic acid and CO2), making selective GA production a central challenge. This review provides a comprehensive overview of recent progress in selective EG-to-GA electrooxidation from catalyst design, mechanistic understanding, …
Why Do We Need To Prove That Pigs Feel?, Aranza Vera-Espinoza, Nancy Harlet Esquivel-Marín
Why Do We Need To Prove That Pigs Feel?, Aranza Vera-Espinoza, Nancy Harlet Esquivel-Marín
Animal Sentience
Birch's framework manages uncertainty but overlooks the likelihood that citizen panels have speciesist biases that reduce precaution to mere harm-management even in species that undoubtedly feel.
Modeling And Simulation Of Solar Battery Charge Controller Using Adaptive Particle Swarm Optimization Mppt Algorithm, Mustafa Sacid Endiz, Göksel Gökkus
Modeling And Simulation Of Solar Battery Charge Controller Using Adaptive Particle Swarm Optimization Mppt Algorithm, Mustafa Sacid Endiz, Göksel Gökkus
Mathematical Modelling and Numerical Simulation with Applications
Implementing an effective Maximum Power Point Tracking method is crucial for optimizing solar energy harvesting against environmental fluctuations like solar radiation and temperature. This paper introduces a novel approach for modeling and simulating a solar battery charge controller, using a modified Particle Swarm Optimization algorithm. The power stage of the system is based on a SEPIC converter, which is employed to manage the power conversion and improve the energy transfer to the battery. The developed circuit model is evaluated under various radiation levels at a constant temperature, as well as under different temperature levels at a constant radiation. Simulations are …
Use Of Technology May Negatively Impact Learners, Dajsha A. Avery
Use Of Technology May Negatively Impact Learners, Dajsha A. Avery
Masters Projects
Integration of technology has changed classrooms vastly in the 21st century. The research evaluates if the use of technology may negatively impact young learners. The Theory of Constructivism developed by Jean Piaget and Lev Vygotsky encourages the integration of technology in the classrooms because it allows the students to lead their educational journey. It is discovered that using technology allows students to be more engaged, self-paced and work on specific skills. Additionally, educational apps are helpful to build confidence and are an incentive for students while practicing skills. Yet, it is recommended to only allow up to 7 hours …
Reducing Seclusion In Inpatient Psychiatric Units Through Staff Education, Amaka Nkala
Reducing Seclusion In Inpatient Psychiatric Units Through Staff Education, Amaka Nkala
Walden Dissertations and Doctoral Studies
Seclusion remains a restrictive intervention used in inpatient psychiatric settings despite evidence linking it to psychological trauma, physical harm, and adverse patient outcomes. This Doctor of Nursing Practice (DNP) staff education project evaluated the effectiveness of a trauma-informed care and de-escalation education program in improving nurses' confidence in managing patient escalation. The project used a pre- and post-intervention quality improvement design with 24 inpatient psychiatric nurses. Participants completed a 10-item, 5-point Likert-scale confidence survey before and after a 30-minute educational session delivered via PowerPoint. Descriptive statistics were used to compare pre- and post-intervention confidence scores. Mean confidence scores increased from …
Staff Education To Increase Knowledge For Reducing Hospital-Acquired Pneumonia, Tenika Monique Mcmillan
Staff Education To Increase Knowledge For Reducing Hospital-Acquired Pneumonia, Tenika Monique Mcmillan
Walden Dissertations and Doctoral Studies
The purpose of this Doctor of Nursing Practice (DNP) project was to address a critical gap in nursing knowledge regarding oral care and its role in preventing hospital-acquired pneumonia (HAP) through staff education. Although the relationship between oral care and pneumonia is well established, staff knowledge at the site varied, leading to inconsistencies in oral care practices. To address this problem, a targeted educational session using a pre- and post-test design was delivered to nursing staff. The practice-focused question was “Among nursing staff working in community living centers, does the implementation of targeted education on evidence-based oral hygiene guidelines, compared …
Staff Education Project To Teach Mobility And Sensory Aid Optimization Delirium Prevention Bundle For Older Patients In A Hospital Health System, Lerato Catherine Modise
Staff Education Project To Teach Mobility And Sensory Aid Optimization Delirium Prevention Bundle For Older Patients In A Hospital Health System, Lerato Catherine Modise
Walden Dissertations and Doctoral Studies
Delirium is a preventable and manageable neuropsychiatric condition characterized by acute fluctuations in attention, awareness, and cognition. The burden of this acute confusion syndrome among older adults aged > 65 years is disproportionate higher, due to age-related neurocognitive vulnerabilities. Nurse-led delirium prevention interventions can reduce incidence from 70% to 20% following structured education, gaps persist in nursing knowledge around evidence-based prevention strategies. The purpose of this project was to evaluate whether a structured nursing education intervention on enhanced mobility and sensory aid optimization strategies, as components of the ABCDEF bundle, improved nursing knowledge compared to standard care practices. Nineteen registered nurses …
Standardized Proactive Glp-1 Prior Authorization Workflow, Ebote Etape
Standardized Proactive Glp-1 Prior Authorization Workflow, Ebote Etape
Walden Dissertations and Doctoral Studies
Summary This quality improvement project evaluated an organizational process change from a reactive, pharmacy-initiated prior authorization (PA) process to a standardized, proactive PA workflow for glucagon-like peptide-1 (GLP-1) receptor agonists in an outpatient primary care clinic. The evidence-based practice PICOT question was: In adult primary care patients prescribed GLP-1 receptor agonists (P), does a standardized, proactive prior authorization workflow (I), compared with a reactive pharmacy-initiated process (C), reduce time to approval and improve approval rate (O) over a 4-week period (T)? Baseline data showed that 3 of 19 PA requests were approved, while 16 were denied, resulting in a 15.8% …
Reducing Hospital-Acquired Pressure Injuries In Acute Care Using Structured Prevention Strategies, Yemisi Adesuyi Akinfenwa
Reducing Hospital-Acquired Pressure Injuries In Acute Care Using Structured Prevention Strategies, Yemisi Adesuyi Akinfenwa
Walden Dissertations and Doctoral Studies
Pressure injuries that patients develop while hospitalized continue to be a major safety concern in hospitals treating very sick patients. These wounds hurt, make infections more likely, keep people in the hospital longer, and increase expenses. On many units, the steps meant to stop these injuries, like checking each patient's risk level and turning patients regularly are not carried out the same way for everyone. Because of this inconsistency, some patients develop preventable pressure injuries. The purpose of this Doctor of Nursing Practice (DNP) project was to create a clinical practice guideline (CPG) for organized pressure injury prevention and to …
Genotypic Triggers: Exposing Pharmacogenomic Blind Spots Via Host-Specific Backdoors In Generative Antimicrobial Peptide Models, Doniyorkhon Obidov, Xiaolong Guo, Yonghui Li, Kaichen Yang
Genotypic Triggers: Exposing Pharmacogenomic Blind Spots Via Host-Specific Backdoors In Generative Antimicrobial Peptide Models, Doniyorkhon Obidov, Xiaolong Guo, Yonghui Li, Kaichen Yang
Michigan Tech Publications
Large Language Models (LLMs) have accelerated drug discovery, particularly in the automated design of antimicrobial peptides (AMPs). However, current validation pipelines for peptide generation models overlook historical precedents showing that certain drugs carry health risks predominantly for individuals with specific genetic profiles. In this paper, we demonstrate that such targeted health risks can be induced intentionally and at scale by manipulating models that generate peptide candidates. We introduce the Genotypic Trigger, a backdoor attack that shifts a model’s generative distribution toward peptides with elevated predicted immunogenicity risk, an adverse immune reaction, specifically for carriers of a tar- geted HLA allele, …