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Articles 70411 - 70440 of 1736782
Full-Text Articles in Entire DC Network
Buprenorphine Salivary Gland Accumulation Sustaining High Oral Fluid Exposure And Increasing The Risk Of Streptococcus Mutans Biofilm Formation, Zicong Zheng, Jie Chen, Songpol Srinual, Vesna Tumbas Šaponjac, Taijun Yin, Bing-Yan Wang, Rongjin Sun, Ming Hu
Buprenorphine Salivary Gland Accumulation Sustaining High Oral Fluid Exposure And Increasing The Risk Of Streptococcus Mutans Biofilm Formation, Zicong Zheng, Jie Chen, Songpol Srinual, Vesna Tumbas Šaponjac, Taijun Yin, Bing-Yan Wang, Rongjin Sun, Ming Hu
Faculty, Staff and Student Publications
Objectives: The US Food and Drug Administration (FDA) issued a warning about buprenorphine-induced dental caries of unknown mechanism in 2022. To investigate the potential mechanism, the association between local buprenorphine exposure and dental biofilm formation will be explored in this study.
Methods: Female F344 rats were dosed with sublingual buprenorphine film or intravenous injection to explore the oral cavity exposure of the buprenorphine. The buprenorphine distribution in salivary glands after the sublingual and intravenous administration was also evaluated. To investigate the effects of buprenorphine exposure on dental caries formation, buprenorphine's impact on the biofilm formation of S. mutans in vitro …
Women's Unique Health Needs And The Sustainable Development Goals: A Meeting Report From The 79th United Nations General Assembly Science Summit, Irene Aninye, Sarah Chew, Nicole Althaus, Michele Barry, Ru-Fong Cheng, Carolyn Harris, Eleanor Nwadinobi, Beth Battaglino, Aisha Brooks, Marleen Temmerman
Women's Unique Health Needs And The Sustainable Development Goals: A Meeting Report From The 79th United Nations General Assembly Science Summit, Irene Aninye, Sarah Chew, Nicole Althaus, Michele Barry, Ru-Fong Cheng, Carolyn Harris, Eleanor Nwadinobi, Beth Battaglino, Aisha Brooks, Marleen Temmerman
Centre of Excellence in Women and Child Health
Biological sex, hormones, and gender uniquely affect health and disease, often resulting in disparities for women across the lifespan and from different racial and ethnic groups, geographical locations, and socio economic backgrounds. Without intentional investment and infrastructure to support good health and wellbeing for women,half of the world’s population remains vulnerable to preventable morbidity and mortality. The Society for Women’s Health Research and ECHAlliance–The Global Health Connector convened a women’s health programas part of the 10th Annual Science Summit during the United Nations 79th General Assembly. This hybrid event was held in New York, NY, (USA) and virtually in September …
Policy Evaluation With Nonlinear Trended Outcomes: Covid-19 Vaccination Rates In The United States, Lynn Bergeland Morgan, Peter C. B. Phillips, Donggyu Sul
Policy Evaluation With Nonlinear Trended Outcomes: Covid-19 Vaccination Rates In The United States, Lynn Bergeland Morgan, Peter C. B. Phillips, Donggyu Sul
Research Collection School Of Economics
This paper discusses pitfalls in two way fixed effects (TWFE) regressions when the outcome variables contain nonlinear and possibly stochastic trend components. If a policy change shifts trend paths of outcome variables, TWFE estimation can distort results and invalidate inference, especially in a context of evolving policy decisions. A robust solution is proposed by allowing for dynamic club membership empirically using a relative convergence test procedure. The determinants of respective club memberships are assessed by panel ordered logit regressions. The approach allows for policy evolution and shifts in outcomes according to a convergence cluster framework with transitions over time and …
Less Is More! The Power Of Micro-Influencers: A Systematic Literature Review, Emine Kuzoren, Irem Kiris, Ismail Erkan
Less Is More! The Power Of Micro-Influencers: A Systematic Literature Review, Emine Kuzoren, Irem Kiris, Ismail Erkan
Journal of Global Business Insights
This paper aims to review micro-influencer marketing literature to identify gaps and provide directions for future research. The authors critically assessed 99 articles that appeared in the Scopus database. As a common outcome of the findings and emerging models from studies in the literature, a comprehensive conceptual model is proposed to guide future research. It has been concluded that micro-influencers differ significantly from others in terms of their interaction power and perceived high credibility in social media marketing. Additionally, the findings clarify the uncertainty regarding the classification of social media influencers. The paper not only identifies influencers but also highlights …
Exploring The Contextual Antecedents Of Nonfamilial Aggression In Women Arrested For Aggressive Behavior, Tatiana Pouncy
Exploring The Contextual Antecedents Of Nonfamilial Aggression In Women Arrested For Aggressive Behavior, Tatiana Pouncy
Walden Dissertations and Doctoral Studies
The prevalence of physical aggression among women has increased, challenging traditional gender norms that portray women as nurturing and nonviolent. While most research on aggression has focused on men, children, or intimate partner violence, research is sparse concerning female aggression outside familial contexts. In this qualitative multiple-case study, the contextual antecedents of nonfamilial aggression in women arrested for aggressive behavior were explored using the general aggression model as the theoretical framework. Data were obtained from 20 publicly documented cases using archival sources such as media stories, court documents, and video recordings. According to thematic and document analysis, aggressive behavior was …
Examining Nurses’ Perspectives Of Organizational Strategies Designed To Enhance Job Satisfaction, Kerine J. Moodie-Brown
Examining Nurses’ Perspectives Of Organizational Strategies Designed To Enhance Job Satisfaction, Kerine J. Moodie-Brown
Walden Dissertations and Doctoral Studies
Nurse job satisfaction remains a critical issue in healthcare, as it directly impacts patient care quality, nurse retention, and organizational performance. Despite numerous organizational efforts, there is limited qualitative insight into how nurses perceive strategies aimed at improving their satisfaction. The purpose of my study, guided by Maslow’s hierarchy of needs theory, was to explore nurses’ perceptions of organizational strategies designed to enhance job satisfaction, with a particular focus on interventions such as pay incentives, workplace safety, career development opportunities, nurse residency programs, and initiatives promoting well-being. Semi-structured interviews were conducted with 10 RNs having at least 1 year of …
Examining The Influence Of Encoding And Retrieval Contexts On 2- To 4-Year-Olds' Acquisition Of Nouns And Verbs, Piper Swearengin, Patrick Mihalicz, Leah Marsh, Zoe Baker, Faith Perry, Susan A. Graham, Jane B. Childers
Examining The Influence Of Encoding And Retrieval Contexts On 2- To 4-Year-Olds' Acquisition Of Nouns And Verbs, Piper Swearengin, Patrick Mihalicz, Leah Marsh, Zoe Baker, Faith Perry, Susan A. Graham, Jane B. Childers
Psychology Faculty Research
This study investigates whether the context in which a word is learnt affects noun and verb learning. There is mixed evidence in studies of noun learning, and no studies of background perceptual context in verb learning. Two-, three-, and four-year-olds (n = 162) saw a novel object moved in a novel way while hearing four novel words, either nouns or verbs. They were asked to generalize the word to a similar action or object shown in the same or different context. Results demonstrate that 2- and 3-year-olds were more accurate at test when learning nouns than verbs, demonstrating that verb …
Opioid Withdrawal Treatment: Buprenorphine/Naloxone (Suboxone), Children's Mercy Kansas City
Opioid Withdrawal Treatment: Buprenorphine/Naloxone (Suboxone), Children's Mercy Kansas City
Clinical Pathways
No abstract provided.
Stand For Support, Shatter The Silence: Administrative Approaches To Eradicate Bullying In Higher Education, Elaine M. Mora, Shawn P. Saladin
Stand For Support, Shatter The Silence: Administrative Approaches To Eradicate Bullying In Higher Education, Elaine M. Mora, Shawn P. Saladin
School of Rehabilitation Services & Counseling Faculty Publications
Bullying in higher education has become a widespread and complex issue that affects staff, faculty, and students worldwide, causing a detrimental impact on both psychological health and academic achievement. This paper provides a comprehensive examination of the phenomenon, encompassing all its manifestations, underlying causes, and significant consequences. The study, which draws on academic literature, outlines the various forms of bullying, including cyberbullying, mobbing, microaggressions, and social exclusion, and highlights the adverse effects these behaviors have on both individuals and academic communities. The research emphasizes how critical it is to comprehend the power relationships that exist in higher education settings and …
Plan And Track Your Performance For A Better Practice, Michelle C. Dziurgot
Plan And Track Your Performance For A Better Practice, Michelle C. Dziurgot
The Journal of the Michigan Dental Association
This editorial stresses the critical need for every dentist to track key performance indicators such as production, profit, and overhead to ensure long-term practice success. It advocates for setting and monitoring daily, weekly, and monthly goals for both doctor and hygiene departments. Strategies for effective practice management include regular team meetings, optimizing supply audits to eliminate unused materials, and planning for seasonal patient fluctuations to keep overhead in sync. The author also emphasizes the importance of providing proper training for the dental team, such as the MDA’s X-ray certification or the Certified Dental Business Professional designation, to enhance patient communication, …
J Mich Dent Assoc September 2025
J Mich Dent Assoc September 2025
The Journal of the Michigan Dental Association
Each month, The Journal of the Michigan Dental Association provides news, information, and features about Michigan dentistry to our state's oral health community and the MDA's 6,200+ members. It stands as the primary publication reaching Michigan dentists.
The September issue marks the return to a hybrid publishing schedule, with print issues published bimonthly in January, March, May, July, September, and November, and online-only digital issues in February, April, June, August, October, and December. This return to print follows a suspension in May due to association-wide financial issues, with the MDA Board of Trustees approving changes in the 2025 budget to …
Dean’S Report: Detroit Mercy Dental - Dental Schools — Safeguarding The Future Of Oral Health, Mert N. Aksu Dds, Jd, Mhsa, Cert. Dph
Dean’S Report: Detroit Mercy Dental - Dental Schools — Safeguarding The Future Of Oral Health, Mert N. Aksu Dds, Jd, Mhsa, Cert. Dph
The Journal of the Michigan Dental Association
This report from the University of Detroit Mercy School of Dentistry highlights its mission to prepare students as clinicians, leaders, and advocates for public health and equitable access to care, emphasizing evidence-based practices and community service. It addresses critical public health measures like community water fluoridation and HPV vaccination, advocating for policies that protect oral health. The report notes concerns over proposed Michigan Medicaid dental program changes that could burden dental schools with increased uncompensated and emergency care. Initiatives to meet workforce needs include the new Detroit Mercy Dental Vermont Track and community-based education programs, which provided care to over …
Mda Services: Practice Acquisition: 6 Ways Mda-Endorsed Companies Can Smooth The Way, Reva Darling
Mda Services: Practice Acquisition: 6 Ways Mda-Endorsed Companies Can Smooth The Way, Reva Darling
The Journal of the Michigan Dental Association
This article outlines six key ways MDA-endorsed companies can facilitate dental practice acquisitions, especially with a high number of dentists retiring. These services include: 1) Real estate valuation and lease review by Bridge Commercial Realty. 2) Acquisition loans and lines of credit through Bank of America Practice Solutions, which offers specialized healthcare financing and discounts for MDA members. 3) Expert assistance with transitioning insurance credentials and PPO network negotiations from PPO Negotiation Solutions to ensure optimal reimbursement. 4) Establishing financial safeguards through Prosperident's Owner Proactive Strategies to prevent embezzlement. 5) Reliable dental gas services from Compass Cryogenics. 6) Solutions for …
Advancing Social Sustainability In Operations And Supply Chain Management: A Multi-Theoretical Exploration Of Technology, Task Familiarity, And Sustainability Interactions, Satabdi Hazarika
Graduate Theses and Dissertations
Social sustainability in operations and supply chain management (OSCM) centers on generating economic value through practices that safeguard people, communities, and broader societal systems impacted by the supply chain. While the importance of such practices is increasingly recognized, firms face persistent challenges in embedding social sustainability into formal management systems. This dissertation tackles three such challenges, with a particular focus on safety in trucking—a vital yet underexamined aspect from the lens of social sustainability. Safety performance in this context is influenced by the complexities of using advanced safety technologies, the demanding and solitary nature of truck driving, and the temporal …
Evaluation Of Tracheal And Cecal Microbial Composition In Heat Stressed Broilers Supplemented With Phytogenic Additives, Andressa Silveira Stein
Evaluation Of Tracheal And Cecal Microbial Composition In Heat Stressed Broilers Supplemented With Phytogenic Additives, Andressa Silveira Stein
Graduate Theses and Dissertations
The rise in global temperatures has become a concern due to its significant impact on the agricultural sector, including poultry production. Heat stress caused by high temperatures directly affects animal welfare, health and productivity, leading to major losses in the poultry sector. In broilers, heat stress affects feed consumption, weight gain, mortality and may also lead to changes in the microbiome, which can increase the predisposition to disease and impact the overall performance of these animals. The aim of this thesis was to reproduce field conditions, simulating an increase in temperature, and to evaluate possible changes in the respiratory and …
Understanding Glufosinate Resistance In Palmer Amaranth And Examination Of Additives For Improved Weed Control, Pamela Carvalho-Moore
Understanding Glufosinate Resistance In Palmer Amaranth And Examination Of Additives For Improved Weed Control, Pamela Carvalho-Moore
Graduate Theses and Dissertations
The aim of this dissertation was to: 1) provide an in-depth review about the potential use of natural and synthetic glutathione S-transferase (GST) inhibitors to enhance herbicidal activity or induce crop safety; 2) determine if the addition of metabolic inhibitors to glufosinate is an effective approach to enhance weed control; 3) investigate the mechanism conferring resistance to glufosinate in a highly-resistant Palmer amaranth accession; 4) characterize the genomic rearrangement involved in glutamine synthetase 2 amplification in a Palmer amaranth accession resistant to both glufosinate and glyphosate; 5) quantify the distribution of glufosinate resistance among Palmer amaranth accessions within a 15-km …
Leviathans And Liberation: Did Whaling Contribute To The Decline Of Slavery?, Topher L. Mcdougal, Austin Choi‐Fitzpatrick
Leviathans And Liberation: Did Whaling Contribute To The Decline Of Slavery?, Topher L. Mcdougal, Austin Choi‐Fitzpatrick
School of Peace Studies: Faculty Scholarship
No abstract provided.
Law Library Blog (September 2025): Legal Beagle's Blog Archive, Roger Williams University School Of Law
Law Library Blog (September 2025): Legal Beagle's Blog Archive, Roger Williams University School Of Law
Law Library Newsletters/Blog
No abstract provided.
Synthesis And Characterization Of Tio2 Nanoparticles Via Hydrothermal And Sol-Gel Technique For Water Treatment, Aya Sami, Selma Al-Jawad, Natheer Jamal Imran
Synthesis And Characterization Of Tio2 Nanoparticles Via Hydrothermal And Sol-Gel Technique For Water Treatment, Aya Sami, Selma Al-Jawad, Natheer Jamal Imran
Journal of Applied Sciences and Nanotechnology
Titanium dioxide (TiO2) has attracted significant interest for water treatment applications due to its non-toxic nature and high photocatalytic activity. In this study, TiO2 nanoparticles were synthesized using two different methods to evaluate their photocatalytic performance in degrading organic contaminants from wastewater. Sample S1 was prepared via the sol–gel method, while sample S2 was synthesized using a hydrothermal approach. X-ray diffraction (XRD) analysis confirmed that both samples crystallized in the tetragonal anatase phase, with average crystallite sizes of 12 nm for S1 and 29 nm for S2. Field-emission scanning electron microscopy (FE-SEM) revealed spherical particles with uniform morphology for both …
Durability, Mechanical, And Corrosion Characteristics Of Recycled Aggregate Concrete Utilizing Locally Sourced Waste And Ultrafine Cerium Oxide, Ansam Hashim, Rana Anaee, Mohammed Nasr
Durability, Mechanical, And Corrosion Characteristics Of Recycled Aggregate Concrete Utilizing Locally Sourced Waste And Ultrafine Cerium Oxide, Ansam Hashim, Rana Anaee, Mohammed Nasr
Journal of Applied Sciences and Nanotechnology
This study seeks to identify an environmentally sustainable method for utilizing the synergetic effects of window glass (WG), ceramic powder (CP), and ultrafine cerium oxide (UFC) in developing concrete containing 25% coarse ceramic aggregate. Four different mixtures were formulated. The first represents control, consisting of 100% ordinary Portland cement (OPC), two other mixtures were composed of 10% WG, 10% CP and 80% OPC, and the fourth mixture consisted of four compositions of 79.5% OPC, 10% WG, 10% CP, and 0.5% UFC. The effect of these additives on recycled ceramic concrete (RA) properties, including workability and setting time, compressive strength, total …
Structural Characteristics Of Alumina Nanoparticles Synthesised By Dc Reactive Sputtering Technique, Noor Naji, Ali Aljubouri, Raid Ismail
Structural Characteristics Of Alumina Nanoparticles Synthesised By Dc Reactive Sputtering Technique, Noor Naji, Ali Aljubouri, Raid Ismail
Journal of Applied Sciences and Nanotechnology
In this work, Al2O3 nanoparticles were synthesized using the DC reactive sputtering technique. A highly pure aluminum target was sputtered within a gas mixture containing oxygen. The structural characteristics of the synthesized nanoparticles were introduced by X-ray diffraction (XRD), field-emission scanning electron microscopy (FE-SEM), energy-dispersive X-ray spectroscopy (EDX), and atomic force microscopy (AFM). An inter-electrode distance of 4 cm can describe the operation parameters, Ar: O2 gas mixing ratio of 50:50, applied voltage of 1500 V and discharge current of 25 mA. The prepared samples showed a polycrystalline structure with an amorphous nature due to the formation of nanoparticles, which …
Optimal And Harmful Social Media Use By Teens With Disabilities: Leveraging Benefits While Minimizing Adverse Effects, Rommel Johnson, Elaine Mora
Optimal And Harmful Social Media Use By Teens With Disabilities: Leveraging Benefits While Minimizing Adverse Effects, Rommel Johnson, Elaine Mora
School of Rehabilitation Services & Counseling Faculty Publications
This article investigates the dual role of social media as both a beneficial and a harmful tool for teens with disabilities (TWDs), emphasizing its impact on identity formation, self-expression, and community engagement. Social media platforms provide TWDs with opportunities for autonomy and empowerment, offering an avenue to connect with peers, share personal stories, and engage in self-advocacy. However, the same platforms pose significant risks, including cyberbullying, loss of privacy, and problematic social media use. The article highlights rehabilitation professionals' need to understand these underlying forces, ensuring that TWDs can leverage social media's benefits while minimizing its adverse effects. By reviewing …
Adaptability Treatment, Amy M. Glaspey
Adaptability Treatment, Amy M. Glaspey
University Grant Program Reports
The funding was used to purchase wearable recording devices (and receivers) to record the speech productions of preschool children engaged in group speech therapy where the adaptability approach was implemented. Data were recorded for speech sound productions and intervention practice to monitor progress and dosage.
Knowledge, Attitude And Practice Of Artificial Intelligence Among Healthcare Professionals: An Online Cross-Sectional Survey, Nikhil R, Divya K L, Mahabaleshwar Mamadapur, Harshwardhan S Patil, Shashirekha B, Hema Sameera Pinnam, Purna Bansal
Knowledge, Attitude And Practice Of Artificial Intelligence Among Healthcare Professionals: An Online Cross-Sectional Survey, Nikhil R, Divya K L, Mahabaleshwar Mamadapur, Harshwardhan S Patil, Shashirekha B, Hema Sameera Pinnam, Purna Bansal
Digital Journal of Clinical Medicine
Background: Deep learning-powered Artificial Intelligence-driven assistance offers enormous potential to improve healthcare by facilitating administrative work, diagnosis, and the treatment of chronic diseases. The gap between clinical values and the day-to-day realities of primary care practice might widen if AI is not successfully incorporated.
Methods: A cross-sectional design was used to evaluate healthcare professionals' perceptions and understanding of AI within a clinical setting. The study was conducted among 456 Health care Workers from May to November 2024.
Results: Among 456 participants, 55.7% were MBBS students/interns, and 37.9% were postgraduates/professionals. More than 50% supported AI integration, and 62.3% of MBBS …
Cardiogenic Shock With Acute Myocardial Infarction Among Older Adults In The United States, Taha Mansoor, Ali Bin Jabbar, Mahmoud Ismayl, Dylan Yu, Kartik Gupta, Sachin Parikh, Austin Brubaker, Abdul Minhas, Dmitry Abramov, Salim S. Virani
Cardiogenic Shock With Acute Myocardial Infarction Among Older Adults In The United States, Taha Mansoor, Ali Bin Jabbar, Mahmoud Ismayl, Dylan Yu, Kartik Gupta, Sachin Parikh, Austin Brubaker, Abdul Minhas, Dmitry Abramov, Salim S. Virani
Population Health, East Africa
Background: Characteristics and outcomes associated with cardiogenic shock (CS) with acute myocardial infarction (AMI) in older patients have not been well characterized.
Objectives: The purpose of this study was to investigate characteristics and outcomes of older patients admitted with CS with AMI.
Methods: We used the National Inpatient Sample database to evaluate clinical characteristics of hospitalizations, clinical outcomes, and health care utilization of hospitalizations of older patients ≥80 years with CS and AMI from 2003 to 2021. We also compared data from older patients with a reference relatively younger patient population (18-79 years).
Results: During the study period, …
Ling 471.01: Phonetics And Phonology, Mizuki Miyashita
Ling 471.01: Phonetics And Phonology, Mizuki Miyashita
University of Montana Course Syllabi, 2021-2025
No abstract provided.
Ling 571.01: Phonetics And Phonology, Mizuki Miyashita
Ling 571.01: Phonetics And Phonology, Mizuki Miyashita
University of Montana Course Syllabi, 2021-2025
No abstract provided.
De Novo Pathogenic Csf1r Variant Implicates Microglial Dysfunction In Pathogenesis Of Febrile Infection-Related Epilepsy Syndrome, Kristen S Fisher, Jesse M Levine, Alexander Ankar, Ruizhi Duan, Yi Chen Lai, Eyal Muscal, Sarah R Risen, James J Riviello, Pei-Chien Tsai, Daniel G Calame
De Novo Pathogenic Csf1r Variant Implicates Microglial Dysfunction In Pathogenesis Of Febrile Infection-Related Epilepsy Syndrome, Kristen S Fisher, Jesse M Levine, Alexander Ankar, Ruizhi Duan, Yi Chen Lai, Eyal Muscal, Sarah R Risen, James J Riviello, Pei-Chien Tsai, Daniel G Calame
Faculty, Staff and Students Publications
Febrile infection-related epilepsy syndrome (FIRES) is a rare presentation of refractory status epilepticus following a febrile illness with resulting refractory epilepsy. Evidence supports the presence of immune dysregulation in patients with FIRES, but a monogenic basis for FIRES has not been identified in most cases. We present a case of a previously healthy 16-year-old male with FIRES who was found to have a de novo predicted damaging missense variant in CSF1R on clinical whole genome sequencing, a gene encoding a critical regulator of microglial homeostasis in which pathogenic variants cause adult onset leukoencephalopathy. Molecular modeling demonstrates that the CSF1R variant …
Characteristics And Outcomes Of Children Initiated On High Flow Nasal Cannula And Continuous Positive Airway Pressure At The Emergency Centre Of A District Hospital In South Africa, Jessica Head, Andrew Redfern, Jana Hoole, Liezl Ulbrich, Refilwe More, Daniël J Van Hoving, Eric D Mccollum, Shubhada Hooli
Characteristics And Outcomes Of Children Initiated On High Flow Nasal Cannula And Continuous Positive Airway Pressure At The Emergency Centre Of A District Hospital In South Africa, Jessica Head, Andrew Redfern, Jana Hoole, Liezl Ulbrich, Refilwe More, Daniël J Van Hoving, Eric D Mccollum, Shubhada Hooli
Faculty, Staff and Students Publications
Introduction: High-flow nasal cannula (HFNC) and continuous positive airway pressure delivered via a nasal interface (nCPAP) are increasingly used for paediatric emergency care in South Africa. In Cape Town, initiation of HFNC/nCPAP at a district hospital, in most instances, necessitates transfer to a paediatric high-care facility. We sought to describe the population of children initiated on HFNC/nCPAP and their short-term hospital outcomes post interfacility transfer.
Methods: The authors conducted a one-year retrospective observational study between August 1st 2021, to July 31st, 2022 of children initiated on HFNC or nCPAP in the emergency centre (EC) of Khayelitsha district Hospital and transferred …
Clinical Phenotype And Outcomes In Autoimmune Encephalitis After Herpes Simplex Virus Encephalitis: A Systematic Review And Meta-Analysis, Jonathan Cleaver, Renetta Chungath, Amy Gimson, Christine Strippel, Bryan Ceronie, Babak Soleimani, Thomas Johnson, Eyal Muscal, Kristen Fisher, Yike Jiang, Timothy A Erickson, Kristy O Murray, Siv Tonje Faret Hovet, Charlotte Aaberg Poulsen, Anna Søgaard Magnussen, Pauline Dumez, Shannon Ronca, Martin Häusler, Annegret Quade, Andrew Swayne, Morten Blaabjerg, Mette Nissen, Alexander J Sandweiss, Jerome Honnorat, Russell Dale, Ming Lim, Michael Eyre, Margherita Nosadini, Lahiru Handunnetthi, Sarosh R Irani, Adam E Handel
Clinical Phenotype And Outcomes In Autoimmune Encephalitis After Herpes Simplex Virus Encephalitis: A Systematic Review And Meta-Analysis, Jonathan Cleaver, Renetta Chungath, Amy Gimson, Christine Strippel, Bryan Ceronie, Babak Soleimani, Thomas Johnson, Eyal Muscal, Kristen Fisher, Yike Jiang, Timothy A Erickson, Kristy O Murray, Siv Tonje Faret Hovet, Charlotte Aaberg Poulsen, Anna Søgaard Magnussen, Pauline Dumez, Shannon Ronca, Martin Häusler, Annegret Quade, Andrew Swayne, Morten Blaabjerg, Mette Nissen, Alexander J Sandweiss, Jerome Honnorat, Russell Dale, Ming Lim, Michael Eyre, Margherita Nosadini, Lahiru Handunnetthi, Sarosh R Irani, Adam E Handel
Faculty, Staff and Students Publications
Background: Autoimmune encephalitis after herpes simplex virus encephalitis (HSVE-AE) represents the intersection of central nervous system infection and autoimmunity. Defining the phenotype and the safety and effectiveness of immunotherapy in HSVE-AE would help identify immunotherapy candidates, optimise therapeutic strategies, and improve patient outcomes.
Methods: We systematically searched Embase, Medline, PubMed, and Web of Science (2007-2024) for cases meeting consensus criteria for AE after confirmed HSVE. Demographics, phenotype, treatment and outcome data were extracted. Dimensionality reduction, network analysis, and multivariate logistic regression was used to explore age- and diagnosis-specific patterns and outcome predictors.
Results: From 2259 articles screened, 78 studies (225 …