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Digging Deeper At Dayton: How Sba Faculty Champion Undergraduate Research, University Of Dayton Oct 2025

Digging Deeper At Dayton: How Sba Faculty Champion Undergraduate Research, University Of Dayton

School of Business Administration Blog

t starts with a question (and a professor who says “yes”)


Alloplastic Implants For Rhinoplasty: A Systematic Review And Meta-Analysis Of Clinical Outcomes And Complications, Rafeni Bunga Cikita, Beta Subakti Nataadmaja Oct 2025

Alloplastic Implants For Rhinoplasty: A Systematic Review And Meta-Analysis Of Clinical Outcomes And Complications, Rafeni Bunga Cikita, Beta Subakti Nataadmaja

Folia Medica Indonesiana

Alloplastic implants emphasize the importance of a comprehensive understanding of both clinical and histological aspects, which are attributed to enhancing patient satisfaction and surgical success rates. The study aims to assess the viability of different implant materials and their related risks over time. A systematic literature search was conducted across multiple databases, including PubMed, Cochrane, and EBSCOhost, to identify 79 records. After eliminating duplicates and applying specific inclusion and exclusion criteria, four new studies were included for evaluation, focusing on postoperative outcomes related to alloplastic implants in rhinoplasty. Late-onset inflammation in non-healthy capsules required removal and showed histological damage. One …


Understanding The Role Of Street Medicine In Harm Reduction: A Case Study Of Street Medicine St. Louis, Ari Gzesh, Jeremiah S Truel, Danielle R Adams, Luke Zabotka, Sara Malone, Nathanial S Nolan Oct 2025

Understanding The Role Of Street Medicine In Harm Reduction: A Case Study Of Street Medicine St. Louis, Ari Gzesh, Jeremiah S Truel, Danielle R Adams, Luke Zabotka, Sara Malone, Nathanial S Nolan

2020-Current year OA Pubs

BACKGROUND: Homelessness results from, and exacerbates, various social determinants of health, including poverty, racism, and inadequate healthcare access, which are further compounded by physical and mental health challenges. The street medicine movement seeks to address these disparities by providing direct medical care and harm reduction services to unsheltered homeless in low-barrier settings. The development of trust is critical to providing this form of care. Few studies have sought to understand the factors influencing trust development in street medicine encounters.

METHODS: This case study of Street Medicine St. Louis aims to explore the factors that influence trust and how trust development …


Vmf: Disruptive Vibro® Technology For Continuous Biomanufacturing Processes, Jarno Robin Oct 2025

Vmf: Disruptive Vibro® Technology For Continuous Biomanufacturing Processes, Jarno Robin

Integrated Continuous Biomanufacturing VII (ICB VII)

Please click Additional Files below to see the full abstract


The Illusion Of Protection: Examining The Enigmatic Privileges Or Immunities Clause, Victoria Hagerott Oct 2025

The Illusion Of Protection: Examining The Enigmatic Privileges Or Immunities Clause, Victoria Hagerott

Richmond Public Interest Law Review

For many years, the United States Supreme Court has protected unenu- merated rights, or rights not expressly stated in the United States Constitu- tion, under the Due Process Clause of the Fourteenth Amendment.! However, the Court has revoked or limited protections for certain unenumerated rights under this Clause in recent years. Most notably, in June 2022, the Supreme Court held in Dobbs v. Jackson Women’s Health Organization that the Con- stitution does not confer the right to an abortion and thereby overtuming nearly fifty years of precedent that began with Roe v. Wade in 19732 To reach its holding in …


Perceived Political Party Divide During The Pandemic: A Framework Linking Attitude Strength Toward Covid-19 Vaccines To Affective Polarization, Hyungjin Gill, Heysung Lee, Soo Yun Kim, Xining Liao, Hernando Rojas Oct 2025

Perceived Political Party Divide During The Pandemic: A Framework Linking Attitude Strength Toward Covid-19 Vaccines To Affective Polarization, Hyungjin Gill, Heysung Lee, Soo Yun Kim, Xining Liao, Hernando Rojas

Communication Faculty Publications

This study examines how perceived political party divide may foster affective polarization during the COVID-19 pandemic. Drawing on nationally representative sample surveys of U.S. and South Korean adults, we investigate the relationship between attitude strength toward COVID-19 vaccines, perceived polarization, and affective polarization. Results suggest that individuals with stronger attitudes toward vaccines are more likely to perceive a greater ideological divide between political parties, which in turn, is associated with increased animosity toward the opposing party. Applying the mediation model to the South Korean sample yielded consistent findings, suggesting that the mechanism by which strong attitudes relate to negative emotions …


Corporate Taxation And Industrial Policy, Reuven S. Avi-Yonah Oct 2025

Corporate Taxation And Industrial Policy, Reuven S. Avi-Yonah

Articles

The Trump administration recently announced two new ventures into industrial policy. First, it will impose a levy on chip exports to China by Nvidia and Advanced Micro Devices (AMD). Under the agreement, Nvidia and AMD will pay the government 15 percent of their gross revenue from sales to China. The secretary of the Treasury has said the administration will consider expanding this type of deal to other industries. Second, the administration announced that it will take a 9.9 percent equity stake in Intel


Me, Myself, And The Influencer: Examining How Parasocial Interaction And Self-Congruence With Social Media Influencers Affects News Media Trust, Ben Wasike Oct 2025

Me, Myself, And The Influencer: Examining How Parasocial Interaction And Self-Congruence With Social Media Influencers Affects News Media Trust, Ben Wasike

Communication Faculty Publications

Social media influencers (SMIs) develop unique relationships with their followers, including high levels of trust and credibility. This study examined how these influencer–follower relationships affect news media trust with a focus on actual self-congruence, ideal self-congruence, parasocial interaction (PSI), and source and message credibility. Data showed that respectively, positive correlations exist between each of these variables and news media trust. However, ordinary least squares (OLS) regression only showed direct effects of actual self-congruence and PSI on trust, while message credibility had a negative effect. Structural equation modeling showed that actual self-congruence positively mediated the relationship between PSI and trust. Overall, …


Atg Conjugation-Dependent/Independent Mechanisms Underlie Lysosomal Stress-Induced Tfeb Regulation, Shiori Akayama, Takayuki Shima, Tatsuya Kaminishi, Mengying Cui, Jlenia Monfregola, Kohei Nishino, Andrea Ballabio, Hidetaka Kosako, Tamotsu Yoshimori, Shuhei Nakamura Oct 2025

Atg Conjugation-Dependent/Independent Mechanisms Underlie Lysosomal Stress-Induced Tfeb Regulation, Shiori Akayama, Takayuki Shima, Tatsuya Kaminishi, Mengying Cui, Jlenia Monfregola, Kohei Nishino, Andrea Ballabio, Hidetaka Kosako, Tamotsu Yoshimori, Shuhei Nakamura

Duncan NRI Faculty and Staff Publications

TFEB, a master regulator of autophagy and lysosomal biogenesis, is activated by several cellular stresses including lysosomal damage, but its underlying mechanism is unclear. TFEB activation during lysosomal damage depends on the ATG conjugation system, which mediates lipidation of ATG8 proteins. Here, we newly identify ATG conjugation-independent TFEB regulation that precedes ATG conjugation-dependent regulation, designated Modes I and II, respectively. We reveal unique regulators of TFEB in each mode: APEX1 in Mode I and CCT7 and/or TRIP6 in Mode II. APEX1 interacts with TFEB independently of the ATG conjugation system, and is required for TFEB stability, while both CCT7 and …


Follow Me Into Math: Near-Peer Influencers Take The Stage, Aaron T. Wilson, Sergey Grigorian, Mayra Ortiz Galarza, Xiaohui Wang Oct 2025

Follow Me Into Math: Near-Peer Influencers Take The Stage, Aaron T. Wilson, Sergey Grigorian, Mayra Ortiz Galarza, Xiaohui Wang

School of Mathematical & Statistical Sciences Faculty Publications

Young people like to be entertained, and to entertain others. What if students were to invest enough of their time and effort into learning topics from our mathematics courses to become experts in the eyes of their peers? In this study we positioned college students and high school students as mathematical performers on the stage in front of their nearpeers, for whom they became math influencers, developing and presenting MathShows. The paper shows readers how we positioned students on the stage, using a 7-step MathShow Design Process informed by a Neer-peer Mathematical Mentoring framework. Of import for educators, researchers and …


Du Bois And The Promotion Of Admissions Diversity: A Post-Grutter Analysis, Austin Burke Oct 2025

Du Bois And The Promotion Of Admissions Diversity: A Post-Grutter Analysis, Austin Burke

Richmond Public Interest Law Review

Today’s outlook on higher education for people of color is in question. Because of the downfall of affirmative action, higher educational facilities must look to factors other than race to increase or maintain diversity. W.E.B. Du Bois viewed education as a means to uplift Black people. In a time of uncertain missions of higher education, and a steadfast commitment to a con- tinuous uplift of the Black community, it is paramount to view all angles of solutions to the end of affirmative action. In analy=zing the shifting educa- tional philosophy of Du Bois against the modern struggle of maintaining di- …


10.06.2025 Ored Connect, Liz Williamson Oct 2025

10.06.2025 Ored Connect, Liz Williamson

ORED Newsletter

  • Field Fest
  • AAAS Membership
  • MIG Application Opportunity
  • Contest to Promote Safe Lab Practices


Investigating Factors Influencing Organic Chemistry Learners' Explanation Sophistication And Representational Competence, Caroline J. Crowder Oct 2025

Investigating Factors Influencing Organic Chemistry Learners' Explanation Sophistication And Representational Competence, Caroline J. Crowder

USF Tampa Graduate Theses and Dissertations

The research presented in this dissertation has two themes: organic chemistry learners’ written explanations and representational competence. Chapters 3 and 4 explore how organic chemistry learners construct explanations of reaction mechanisms, specifically focusing on electrophile and nucleophile components. Chapter 5 investigates organic chemistry learners’ representational competence skills and the relationship between these skills and their performance in the course.

Understanding reaction mechanisms is critical for success in organic chemistry, yet learners often struggle to reason beyond explicit, surface-level features. Constructed-response prompts that ask learners to explain what is happening in a reaction mechanism and why it occurs can provide insight …


Exploring The Correlation Between Pupil Distance And Myopia Prevalence: An Observational Bioanthropology Study In Surabaya, Anggitha Hayuning Kinasih, Dwi Martha Nur Aditya, Y Adhimas Setyo Wicaksono Oct 2025

Exploring The Correlation Between Pupil Distance And Myopia Prevalence: An Observational Bioanthropology Study In Surabaya, Anggitha Hayuning Kinasih, Dwi Martha Nur Aditya, Y Adhimas Setyo Wicaksono

Folia Medica Indonesiana

Bioanthropology integrates biological and cultural perspectives, thereby enhancing our understanding of human health across populations. Myopia is a significant refractive error affecting potentially 2.5 billion people globally by the end of the decade. Bioanthropological theories suggest that pupil diameter and distance contribute to axial elongation and the progression of myopia. Nevertheless, current literature lacks empirical validation through rigorous hypothesis testing, highlighting a gap in comprehension. The research explores the relationship between pupil distance and the incidence of myopia via empirical assessments in Surabaya. An observational cross-sectional study was conducted, which involved pupil distance measurements and eye refraction assessments. Inclusion criteria …


Phytochemisty And Antioxidant Activity Of Ethanol, Ethyl Acetate, And N-Hexane Extracts Of Suruhan Leaves (Peperomia Pellucida), Ade Arsianti, Steven Gill, Diyah Kristanty Oct 2025

Phytochemisty And Antioxidant Activity Of Ethanol, Ethyl Acetate, And N-Hexane Extracts Of Suruhan Leaves (Peperomia Pellucida), Ade Arsianti, Steven Gill, Diyah Kristanty

Indonesian Journal of Medical Chemistry and Bioinformatics

Background: Free radicals are natural byproducts of cellular metabolism, in which, their excessive accumulation can lead to oxidative stress, which plays a key role in the development of various chronic diseases, including cancer, cardiovascular disorders, and neurodegenerative conditions. Antioxidants are compounds capable of scavenging free radicals and minimizing oxidative damage. Peperomia pellucida, commonly known as Suruhan leaves, is a tropical herb traditionally used in folk medicine that contain bioactive compounds correlated with a strong radical-scavenging activity, suggesting its potential as a natural antioxidant source. This study aims to conduct a phytochemical analysis and evaluate the antioxidant activity of ethanol, …


The Free Press Vol. 57, Issue 4, 10-06-2025, Julz Levesque, Caraline Squires Oct 2025

The Free Press Vol. 57, Issue 4, 10-06-2025, Julz Levesque, Caraline Squires

Free Press, The

Shutdown Stalemate--College Dreams at Risk--The Portland Farmer's Market Is in Full Bloom--First Pingo of the School Year--Common Ground Country Fair--USM Honors POW-MIA Recognition Day with Flag Raising Ceremony


New Avenues In Childhood Vasculitis, Marinka Twilt, Seza Ozen Oct 2025

New Avenues In Childhood Vasculitis, Marinka Twilt, Seza Ozen

Faculty, Staff and Students Publications

Childhood vasculitis encompasses a group of rare and heterogeneous diseases with systemic inflammation affecting various vessel sizes. This comprehensive review highlights recent advances in the pathogenesis, biomarkers, diagnosis, and treatment strategies for major pediatric vasculitides including IgA vasculitis, Kawasaki Disease, ANCA-associated vasculitis, Takayasu arteritis, and Polyarteritis Nodosa. Novel insights from genetic, immunologic, and imaging studies have paved the way for early diagnosis and individualized therapeutic approaches. Future directions emphasize the role of artificial intelligence, precision medicine, and international collaborative trials to optimize long-term outcomes and quality of life in affected children.


Early Childhood Special Education Teachers’ Perspectives Of Teaching Social-Emotional Skills During The Covid-19 Pandemic Virtual Learning Period, Dalena Lynette Lafferty Oct 2025

Early Childhood Special Education Teachers’ Perspectives Of Teaching Social-Emotional Skills During The Covid-19 Pandemic Virtual Learning Period, Dalena Lynette Lafferty

Walden Dissertations and Doctoral Studies

During the COVID-19 pandemic, early childhood special education teachers struggled to virtually teach social-emotional skills to their students when schools were closed, and all students were moved from face-to-face to virtual learning. The purpose of this basic qualitative study was to explore early childhood special education teachers’ perspectives on teaching social-emotional skills to their students during the COVID-19 pandemic virtual learning period. Vygotsky’s sociocultural theory was used as the conceptual framework for this study. Data were collected through semistructured interviews with 10 early childhood special education teachers from the United States who had experience with teaching social-emotional skills virtually during …


Rurality’S Impact On Alaska Native Elders’ Levels Of Physical Activity And Obesity, Jessie Doherty Oct 2025

Rurality’S Impact On Alaska Native Elders’ Levels Of Physical Activity And Obesity, Jessie Doherty

Walden Dissertations and Doctoral Studies

While there have been studies on obesity levels and physical activity levels across many populations and age groups, few studies have focused on Alaska Native Elders. The purpose of this study was to examine rurality (urban vs. rural counties), physical activity, and obesity level while controlling for sex, self-reported loneliness, and self-reported stress. The theoretical foundation for this study was based on the socio-ecological model (SEM), and the research questions in this study explored how rurality impacted obesity levels and how rurality impacted physical activity levels in Alaska Native Elders. The methodology of this study was a quantitative cross-sectional design …


A Supplement, Not A Substitute: Accuracy And Completeness Of Chatgpt Responses For Common Elbow Pathology, Phillip Goldman, Pablo Coello, Michael B Gottschalk, Eric R Wagner, Adil Shahzad Ahmed Oct 2025

A Supplement, Not A Substitute: Accuracy And Completeness Of Chatgpt Responses For Common Elbow Pathology, Phillip Goldman, Pablo Coello, Michael B Gottschalk, Eric R Wagner, Adil Shahzad Ahmed

Faculty, Staff and Students Publications

Hypothesis: Large language models (LLMs) like ChatGPT have increasingly been used as online resources for patients with orthopedic conditions. Yet there is a paucity of information assessing the ability of LLMs to accurately and completely answer patient questions. The present study comparatively assessed both ChatGPT 3.5 and GPT-4 responses to frequently asked questions on common elbow pathologies, scoring for accuracy and completeness. It was hypothesized that ChatGPT 3.5 and GPT-4 would demonstrate high levels of accuracy for the specific query asked, but some responses would lack completeness, and GPT-4 would yield more accurate and complete responses than ChatGPT 3.5.

Methods: …


Apoe-Calypse Tau: Apoe-Tau Synergy In Alzheimer's Disease, Matthew Paul Lennol, Chiara Bordier, Léana Kamelher, Jason D Ulrich, David M Holtzman, Maud Gratuze Oct 2025

Apoe-Calypse Tau: Apoe-Tau Synergy In Alzheimer's Disease, Matthew Paul Lennol, Chiara Bordier, Léana Kamelher, Jason D Ulrich, David M Holtzman, Maud Gratuze

2020-Current year OA Pubs

Alzheimer's disease (AD), the most common cause of dementia, is characterized by the accumulation of amyloid-β (Aβ) in senile plaques and abnormally hyperphosphorylated tau proteins in neurofibrillary tangles. While much of the research has focused on Aβ, tau-mediated neurodegeneration is more closely associated with synaptic loss and cognitive decline in AD, emphasizing the need for a deeper understanding of tau pathology. In this context, the interaction between tau and APOE, particularly the main genetic risk factor for AD APOE ε4, remains underexplored. APOE encodes apolipoprotein E (apoE), a protein important in lipid metabolism. In addition to promoting Aβ deposition, emerging …


Rescue Epilepsy Medication And Training: A Comparison Between Midazolam Use, Guidelines, Clinical Practice, And Possibilities In The Uk And Norway, Rohit Shankar Oct 2025

Rescue Epilepsy Medication And Training: A Comparison Between Midazolam Use, Guidelines, Clinical Practice, And Possibilities In The Uk And Norway, Rohit Shankar

Peninsula Medical School

Objectives: Status epilepticus (SE) is a prolonged epileptic seizure carrying significant risk of long-term disability and death. Rescue therapies are prescribedfor prehospital administration to terminate SE. This study compared prescribingpractices of rescue therapies of midazolam in the UK and Norway.Methods: A cross-sectional, online, 21-item Likert-style survey was administeredto epilepsy professionals in the UK circulated via ILAE/ESNA and in Norway viaILAE/Epilepsinet using a non-discriminatory exponential snowballing techniqueleading to non-probability sampling. Data were collected anonymously and analyzed using descriptive statistics, Mann–Whitney, Chi-square, and Fisher's exact tests. Significance was accepted at p<0.05.Results: All 86 UK and 53 Norway respondents identified buccal midazolam as the first-line rescue medication choice in the community for prolonged and/or generalized tonic–clonic seizures. Norwegian respondents had significantly more experience in epilepsy-related work (p=0.002), were more likely to have a larger caseload on buccal midazolam (p<0.001), prescribed higher midazolam doses (p<0.001), and provided training yearly (p<0.001). UK respondents were more likely to delegate rescue medication prescribing to primary care (p=0.006) and reviewed emergency management plans more frequently (p=0.006). There was an inter-country difference in the period of midazolam non-use that respondents required before withdrawing from treatment plans (p<0.001). Concern about inappropriate use of buccal midazolam was similarly high in both countries.Significance: This study compared epilepsy professionals in two neighboringhigh-income countries. Findings suggest an urgent need for international guidelines to recommend best practices on prescribing doses and withdrawal of buccal midazolam. The potential abuse of buccal midazolam by patients and carers warrants further investigation.


Primary Education In Nigeria: A Case Study Of The Global Mandate On Inclusive Education, Olusola John Ogundola Oct 2025

Primary Education In Nigeria: A Case Study Of The Global Mandate On Inclusive Education, Olusola John Ogundola

Theses and Dissertations

This dissertation examines how inclusive education, mandated by Article 24 of the United Nations Convention on the Rights of Persons with Disabilities (UNCRPD), is implemented in primary schools in Oyo State, Nigeria. Using a qualitative case study, I explored administrators’ and teachers’ experiences within contexts shaped by colonial legacies, systemic ableism, and resource constraints. Data sources included policy documents, lesson notes, researcher journals, and interviews. Guided by postcolonial and decolonial theory, Disability Critical Race Theory (DisCrit), and Critical Disability Studies (CDS), the study identified five themes: (1) colonial residues in language and schooling; (2) deficit framings of disability; (3) systemic …


Memories, Realities, And Manifestations: A Fifth Grade Collage Inquiry Of Experiences And Hopes, Idalis Jole' Williams Oct 2025

Memories, Realities, And Manifestations: A Fifth Grade Collage Inquiry Of Experiences And Hopes, Idalis Jole' Williams

Theses and Dissertations

In this qualitative study, I used collage inquiry to explore fifth-grade students' educational, social, and emotional experiences in an elementary school. The participating students began kindergarten in 2020, a year marked by the sudden disruption of the COVID-19 pandemic. The pandemic shaped the foundation of their schooling in many ways. This study helped us understand the student experience using the arts-based research method of collage inquiry. As the principal and researcher, I invited fifth-grade students to participate in a Collage Club that meets twice weekly across five weeks. The students reflected on their experiences and expressed their hopes for the …


Static Malware Analysis For Incident Response: Developing A Tactical Aid With Ember, Joel Meoak, Shengjie Xu Oct 2025

Static Malware Analysis For Incident Response: Developing A Tactical Aid With Ember, Joel Meoak, Shengjie Xu

Journal of Cybersecurity Education, Research and Practice

Incident responders face a variety of challenges when identifying malware using existing solutions, particularly when rapid tactical decisions are needed. Traditional malware detection methods are often signature-based, limiting their effectiveness to previously known threats detected by anti-virus (AV) engines. Online analysis tools introduce confidentiality risks, potentially alerting adversaries that their actions are under scrutiny. While free sandbox environments offer useful capabilities, they often require substantial setup time and hardware resources that may not be available in the field. This research leverages the Elastic Malware Benchmark for Empowering Researchers (EMBER) dataset to develop a lightweight, portable tactical decision aid that enables …


Benchmarking Modern Day Pencil Beam Scanning Proton Therapy Treatment Times: Insights From Real Time Location Service Treatment Time Data, Kristen Mcconnell, Andrew Wroe, Marie Valladares, Lorrie Legrand, Ulrich Ramos, Michael Chuong, Minesh Mehta, Alonso Gutierrez Oct 2025

Benchmarking Modern Day Pencil Beam Scanning Proton Therapy Treatment Times: Insights From Real Time Location Service Treatment Time Data, Kristen Mcconnell, Andrew Wroe, Marie Valladares, Lorrie Legrand, Ulrich Ramos, Michael Chuong, Minesh Mehta, Alonso Gutierrez

All Publications

Purpose: Collecting consistent and accurate treatment time data is challenging, particularly when relying on manual records or predictive models. Our center uses a Real-Time Location System (RTLS), which provides precise, automated tracking of patient movement throughout the clinic. This study leverages RTLS data to benchmark treatment times in a high-volume pencil beam scanning proton facility where ancillary systems like cone beam CT, surface imaging, and ultrasound bladder scans are used to aid in setup.

Materials and methods: We analyzed RTLS data from 12,551 fractions delivered between January 2023 and July 2024 across three gantries of an IBA Proteus Plus system. …


Economic And Policy Drivers Of Climate-Smart Soil Health Practices In The United States, Roderick Rejesus, Serkan Aglasan, Lawson Connor Oct 2025

Economic And Policy Drivers Of Climate-Smart Soil Health Practices In The United States, Roderick Rejesus, Serkan Aglasan, Lawson Connor

Agricultural Economics and Agribusiness Faculty Publications and Presentations

Climate-smart soil health practices, such as cover crops and no-till, are considered to be key elements for climate change adaptation and mitigation in agriculture. We examine the empirical literature that provides data-driven evidence on the impact of cover crops and no-till on several economic variables of interest, such as yields, inputs, profits, risk, erosion, and water quality. In general, existing studies provide mixed evidence on the impacts of cover crops and no-till on these outcomes. Moreover, we discuss the empirical literature exploring the impact of economic and policy-related variables on adopting cover crops and no-till. We find that a number …


Atg16l1 Controls Mammalian Vacuolar Proton Atpase, Thabata L A Duque, Masroor Paddar, Einar Trosdal, Ruheena Javed, Lee Allers, Prithvi Akepati, Michelle Salemi, Brett Phinney, Shawn B Bratton, Thomas Wileman, Vojo Deretic Oct 2025

Atg16l1 Controls Mammalian Vacuolar Proton Atpase, Thabata L A Duque, Masroor Paddar, Einar Trosdal, Ruheena Javed, Lee Allers, Prithvi Akepati, Michelle Salemi, Brett Phinney, Shawn B Bratton, Thomas Wileman, Vojo Deretic

Faculty, Staff and Student Publications

The mechanisms governing mammalian proton pump V-ATPase function are of fundamental and medical interest. The assembly and disassembly of cytoplasmic V1 domain with the membrane-embedded V0 domain of V-ATPase is a key aspect of V-ATPase localization and function. Here, we show that the mammalian protein ATG16L1, primarily appreciated for its role in canonical autophagy and in noncanonical membrane atg8ylation processes, controls V-ATPase. ATG16L1 knockout elevated V-ATPase activity, increased V1 presence on endomembranes, and increased the number of acidified intracellular compartments. ATG16L1's ability to efficiently bind V-ATPase was required for its inhibitory role in endolysosomal acidification and for control of Mycobacterium …


Staff Education Program On Perceived Stress Scale, Juliana Mutua Oct 2025

Staff Education Program On Perceived Stress Scale, Juliana Mutua

Walden Dissertations and Doctoral Studies

This project was a staff education program conducted at a mental health and rehabilitation center in the United States. The program was designed to address a critical gap in practice of limited staff knowledge of using standardized stress assessment tools to assess patient stress, leading to poor patient outcomes. The practice-focused question was: Does staff education on the Perceived Stress Scale (PSS) improve staff knowledge as compared pre- to post-education? The purpose was to enhance staff knowledge on the application and interpretation of the PSS. The Johns Hopkins nursing evidence-based practice (JHNEBP) model was used to organize and evaluate the …


Implementation Of The Patient Health Questionnaire-9 As A Screening Tool For Depression, Nathalie Teboh Njofri Bih Oct 2025

Implementation Of The Patient Health Questionnaire-9 As A Screening Tool For Depression, Nathalie Teboh Njofri Bih

Walden Dissertations and Doctoral Studies

Depression is a common mental health issue that is often misdiagnosed or underdiagnosed in primary care practice due to a lack of appropriate screening. The practice problem addressed by this project was the inconsistent use of standardized tools, like the Patient Health Questionnaire (PHQ-9), which hinders timely and accurate depression diagnosis. The practice-focused question was: Does educating staff impact their knowledge of the recommended use and interpretation of the PHQ-9 and their confidence in administering the tool? I aimed to enhance depression screening practices by educating nursing staff on administering, scoring, and integrating the PHQ-9 into routine patient care. For …