Digital Commons Network^™

Biotechnologies And The Treaty Gap: Why Biological Weapons Governance Is Falling Behind; And Some Thoughts On How To Fix It, James Giordano

Strategic Insights

This commentary examines how rapid advances in biotechnology are outpacing the ability of existing international agreements, especially the Biological Weapons Convention (BWC), to effectively govern emerging risks. Dr. Giordano explains that technologies such as synthetic biology, gene editing, and AI-assisted biological design are creating capabilities that blur the line between legitimate research and potential misuse, leaving enforcement and oversight systems outdated. These developments expose a “treaty gap” in which governance does not match technological reality, undermining global norms against biological weaponization. Strengthening international governance frameworks, improving transparency and verification mechanisms, and incorporating emerging science into treaty language will be essential …

Book Review: Move Slowly And Build Bridges: Mastodon, The Fediverse, And The Struggle For Democratic Social Media, Ben Pettis

Rhetoric and Communication Studies Faculty Publications

Put simply, today’s landscape of social media is a bit of a mess. A swath of recent scholarship has rightly tracked major shifts in social media, including the rise of walled gardens, enshittification (Doctorow, 2023), numerous privacy concerns (Couldry and Mejias, 2019; Marwick, 2023), and the general rise of what Shoshana Zuboff (2020) has termed ‘surveillance capitalism’. Though social media has undoubtedly brought many benefits, it is increasingly difficult to overlook its negative underbelly. Given this context, Robert Gehl’s recent book, Move Slowly and Build Bridges makes a timely contribution to studies of new media …

Titin-Related Familial Dilated Cardiomyopathy: Factors Associated With Disease Onset, Renee Johnson, Robert A Fletcher, Stacey Peters, Monique Ohanian, Magdalena Soka, Andrei Smolnikov, Katherine E Abihider, Michael J Ackerman, Flavie Ader, Mohammed M Akhtar, Ahmad S Amin, Euan A Ashley, John J Atherton, Rachel Austin, Annette F Baas, Richard D Bagnall, Samantha Barratt Ross, Jean-Louis Blouin, Emily E Brown, Henning Bundgaard, Douglas Cannie, Przemyslaw Chmielewski, Gemma Correnti, Maria Generosa Crespo-Leiro, Matteo Dal Ferro, Lisa M Dellefave-Castillo, Fernando Dominguez, Dennis Dooijes, Anne M Dybro, Youssef Ed Demri, Mohamed El Hachmi, Luis Escobar-Lopez, Sarah Jajesnica Foye, Maria Franaszczyk, Marta Gigli, Esther Gonzalez Lopez, Adeline Goudal, Sharon Graw, Michel Guipponi, Eric Haan, Jan Haas, Daniel J Hammersley, Frederikke G Hansen, Christopher S Hayward, Thomas Morris Hey, Stephane Heymans, Carolyn Y Ho, Arjan C Houweling, Jodie Ingles, Angela Ingrey, Andrew Jabbour, Paul A James, Joeri A Jansweijer, Jan D H Jongbloed, Anne M Keogh, Jose M Larrañaga-Moreira, Ronald H Lekanne Deprez, Ivan Macciocca, Peter S Macdonald, Nicolas Mansencal, Julia Mansour, Cristina Martinez-Veira, Barbara Mcdonough, Julie Mcgaughran, Kristen Medo, Marco Merlo, Ewa Michalak, Lorenzo Monserrat, Helen Mountain, Steven A Muller, Anne M Murphy, Brittney Murray, Emily C Oates, Elizabeth Ormondroyd, Nicholas Pachter, Alessia Paldino, Aurélien Palmyre, Naveen L Pereira, Kermshlise C Picard, Nicola Poplawski, Sanjay Prasad, Julie Proukhnitzky, Jean-Francois Pruny, Patricia Reant, Pascale Richard, Anne Ronan, Farbod Sedaghat-Hamedani, Christopher Semsarian, Garrett Storm, Sophie Stroeks, Petros Syrris, Matthew R G Taylor, Kate Thomson, Tina Thompson, J Peter Van Tintelen, Christoffer Rasmus Vissing, Kathryn E Waddell-Smith, Mathew Wallis, Dominica Zentner, Clare Arnott, Ali J Marian, Jaewon Oh, Siv Fokstuen, Cynthia A James, Roberto Barriales-Villa, Benjamin Meder, Karim Wahbi, John R Giudicessi, Victoria N Parikh, James S Ware, Nicolas Piriou, Caroline Rooryck, Neal K Lakdawala, Luisa Mestroni, Gianfranco Sinagra, Perry M Elliott, Hugh Watkins, Elizabeth M Mcnally, Philippe Charron, Karin Y Van Spaendonck-Zwarts, Pablo Garcia-Pavia, Maria Luisa Peña-Peña, Jens Mogensen, Alex Hoerby Christensen, Zofia T Bilińska, Torsten B Rasmussen, Jonathan G Seidman, Christine E Seidman, Anneline S J M Te Riele, Job A J Verdonschot, Yigal M Pinto, Imke Christiaans, Diane Fatkin

The Brown Foundation: Institute of Molecular Medicine

Background and aims: Truncating variants in the TTN gene (TTNtv) are the most common genetic cause of dilated cardiomyopathy (DCM) but also occur as incidental findings in the general population. This study investigated factors associated with the clinical manifestation of TTNtv.

Methods: An international multicentre retrospective observational study was performed in families with TTNtv-related DCM. Shared frailty models were used to estimate associations of variant characteristics with lifetime risk of DCM, and logistic regression to estimate odds ratios (ORs) for individual-level clinical risk factor profiles (cardiac conditions, cardiovascular comorbidities, lifestyle) and DCM.

Results: A total of 3158 subjects in 1043 …

Parliamentary Gridlock In Tanzania: An Examination Of The Politics Of Changing The Cashew Nut Industry Act (Cap 203), Palme Kawishe

Tanzania Journal of Sociology

The legislature plays a pivotal role in overseeing the management of public resources through the budget process, which provides a formal forum for debating how funds are mobilised, allocated, and spent. Through this process, the legislature reviews and amends the laws governing a government’s annual revenues and expenditures. However, legislative review is often shaped by underlying political dynamics. Focusing on legislative-executive relations, this article examines the political dynamics that unfolded in Tanzania’s parliament during the amendment of the Cashew Nut Industry Act (Cap. 203) and how these dynamics produced parliamentary gridlock. It further explores how the fusion of party and …

Staff Education For Effective Patient Handoff, Kaylonn Amundson

Walden Dissertations and Doctoral Studies

This staff education project was initiated to address the lack of standardized handoff procedures which was found to have contributed to an adverse outcome for a hospitalized patient. The purpose of this project was to address the question: Will an interactive education program on a standardized handoff tool increase nursing staffs’ knowledge and self-confidence regarding its use? The project involved educating 20 inpatient nurses and care staff about the structure of the SIGNOUT? handoff tool using a PowerPoint presentation with a follow-up practice simulation. Handoff sheets and visuals were distributed to aid in the learning process. Pre- and post-education surveys …

Intouch Week Of December 22, 2025, New York Medical College

InTouch

• Marking the Moments of 2025
• NYMC and Hudson Regional Health Form Academic Affiliation
• Simultaneous Heart-Kidney Transplant Brings Higher Risk
• A Closer Look at Medical Careers
• The Latest Issue of TCDM Apex is Available
• Faculty Spotlight: From Response to Real Impact

Legal Issues Arising From The Military Use Of Ai-Supported Biometrics, Marten Zwanenburg

International Law Studies

Biometrics is increasingly used by armed forces for a variety of purposes, such as access control, the registration of detainees, and increasingly also targeting. The capabilities of biometric systems are considerably strengthened when they are enabled by artificial intelligence (AI). This article analyzes legal questions that are raised by the military use of such AI-supported biometrics. It argues that relevant legal frameworks are International Humanitarian Law, international human rights law, and the right to privacy in particular, as well as data protection law. The article finds that arguably, IHL may require the use of (AI-supported) biometrics in certain situations if …

A Critical Annotated Bibliography Of Obscure Scholarship On John Kennedy Toole And A Confederacy Of Dunces. Version 2.0, H. Vernon Leighton

Library Faculty Works

The purpose of this bibliography is to summarize texts that might be difficult for the average scholar to obtain and to evaluate the quality of those obscure texts. Most of these are Master’s theses or Ph.D. dissertations that have at least some portion devoted to a discussion of John Kennedy Toole or the novel A Confederacy of Dunces. Most of the entries were written before 2014, though some were updated in 2025.

Epcam Activates The Erk-Egr1 Signaling Axis And Promotes Tnf-Α-Induced The Progression Of Anaplastic Thyroid Cancer, Chi-Chiu Lee, Yi-Jen Su, Sushree Shankar Panda, Chiung-Yi Chiu, Chung-Hsuan Wu, Tsai-Ming Lu, Pi-Chun Li, Yen-Lin Huang, Ruey-Long Hong, Shao-Hsi Hung, Cassian Yee, Stephen Y Lai, Han-Chung Wu

Faculty, Staff and Student Publications

Background: Epithelial cell adhesion molecule (EpCAM) is a pleotropic transmembrane glycoprotein comprising an extracellular domain (EpEX), a single transmembrane domain, and an intracellular domain (EpICD). For several types of cancer, high EpCAM expression is associated with tumor progression, metastasis, immune evasion, and overall poor prognosis. A rare but aggressive form of thyroid cancer, anaplastic thyroid cancer (ATC), has a mean survival time of only 3–6 months after diagnosis.

Methods: The levels of EpEX and EpICD cleavage in clinical patient samples was evaluated by using tissue microarray. Capture enzyme-linked immunosorbent assay (ELISA) was conducted to explore the of shedding EpEX and …

Video Conversation Aids To Assist In Goals-Of-Care Discussions With Older Adults In A Medical Setting: A Systematic Review, Ashna S Karpe, Mokunfayo O Fajemisin, Stephanie Martinez Ugarte, Lara Ouellette, Martin L Blakely, Gina H Khraish, Shreyans V Sanghvi, Min J Kwak, Jessica L Lee, Lillian S Kao, Thaddeus J Puzio

Library Staff Publications

Background

Methods

Charters In Patient-Engaged Research: A Scoping Review Of Current Evidence, Jenny Martínez, Catherine V. Piersol, Richard W. Hass, Felicia Chew, Amy Cunningham, Sharon L. Larson

College of Population Health Faculty Papers

AIMS: Research study charters facilitate shared governance and power sharing with research partners when developed collaboratively and early on in a study. Study charters are negotiated and developed on a study-by-study basis, offering insight into study-specific dynamics between research partners and investigators, as well as the factors that each identify as important for their collaboration. This review aimed to map and synthesize existing evidence on the development, structure, and implementation of research study charters used in patient-engaged research.

METHODS: We searched peer-reviewed literature published worldwide in English between January 2019 and January 2025.

RESULTS: Our final sample consisted of 17 …

What Is The Most Important Issue In Indonesia’S Political Belief System? Network Analysis Of Attitude And Voting Behavior In 2014 And 2019, Khaerullah Fadhli Arasy Hasan, Whinda Yustisia, Mirra Noor Milla, Mark Brandt

Makara Human Behavior Studies in Asia

Previous research has shown that attitudes toward political issues have a significant influence on voting behavior (Bukari et al., 2022). However, not all issues exert equal influence, and some may have a more direct impact on voting behavior than others. This study applies network analysis within the framework of the PBS model (Brandt & Sleegers, 2021) to explore the issues that most strongly shaped voters’ choices in Indonesia’s 2014 and 2019 elections. To answer the research question, we used data from a national survey (n = 962) conducted in 2018. The analysis was conducted by evaluating the shortest path values …

The Bridwell Quill: Issues 86–88: If On A Single Night A Traveler, Anthony J. Elia

Bridwell Library Publications

No abstract provided.

Advancements In Perfect Matchings Within Neutrosophic Fuzzy Graphs: Theory And Applications, Muhammad Saeed, Fatima Razaq

Neutrosophic Systems with Applications

Graph theory has been widely used in exemplifying relational structure, and a greater generalization to fuzzy and neutrosophic space enables the exemplification of uncertainty, indeterminacy, and inconsistency in complex systems. Some of these extensions include the neutrosophic fuzzy graphs that provide a more detailed description of the loose relations between the vertices and the edges. However, unlike in classical graph theory, where the concepts of matching and perfect matching are well developed, very little has been studied on how the two concepts can be extended to neutrosophic fuzzy graphs. To seal this gap, the current paper develops and defines the …

Integrating Mcdm Techniques For Optimized Task Offloading In Multi-Uav- Enaled Mobile Edge Computing System, Amira Salam

Neutrosophic Systems with Applications

Carefully choosing a task offloading strategy is crucial for optimizing task scheduling and offloading strategies in a multi-UAV system. Regarding cost, responsiveness, scalability, and data security, each strategy has pros and cons. As a result, selecting the best offloading technique is essential to multi-UAV mobile edge computing task scheduling optimization. A methodical and well-informed decision-making process accomplishes this.

The current study introduces a new hybrid methodology for the multi-criteria decision-making (MCDM) model, known as IVNs-DEMATEL-ANP-VIKOR. The purpose of this model is to find and choose an efficient task offloading strategy. With this method, we use IVNs-DEMATEL to show how different …

Customer Experience, Engagement, And Co-Creation In Augmented Reality Retail Service, Amjad Abu Elsamen, Linda D. Hollebeek, Saifeddin Alimamy, Nikolaos Stylos, Weng Marc Lim

All Works

Retailers are increasingly using augmented reality (AR) to enhance the customer experience. This research investigates how AR service experiences contribute to customer co-creation. Two experimental studies using real AR applications and PLS-SEM provide evidence. Study 1, utilizing IKEA Place and WannaKicks, examines whether network externality enhances experience quality and whether customer autonomy influences this effect. Results show that network externality enhances experience quality, but the effect weakens at higher levels of autonomy, indicating that autonomous customers rely less on network cues. Study 2, utilizing Warby Parker and Dulux Visualizer, examines whether experience quality influences co-creation through engagement and whether the …

Powering Up Clinical Scholarship In Shiprock Family Medicine, Evelyn Wang

HSLIC Faculty and Staff Instructional Resources

This presentation is designed for Shiprock–UNM Family Medicine residents and faculty, focusing on developing practical clinical scholarship skills within a full-spectrum family medicine context.Note-20250116.docx+1 Key topics include research question formation (PICOT, FAC Rubric), navigation of core clinical resources (PubMed, EMBASE, CINAHL, ClinicalKey, UpToDate, HSLIC LibGuides), advanced literature search techniques (Boolean operators, truncation, wildcards, proximity operators, subject headings), strategies for capturing search strategies and documenting basic search methods, use of full-text access tools (LibKey Nomad, proxy authentication, interlibrary loan and document delivery), introduction to critical appraisal tools (CASP, JBI, PRISMA-S), and an overview of publishing supports (Zotero, ORCID, UNM Digital Repository, …

Get Creative With New Classes From Artplay, Shannon Thomason

Browse All News

No abstract provided.

Ai In Health Professions Education, Cindy Schmidt

Faculty and Staff Publications

No abstract provided.

Enhancing Wind Turbine Aerodynamics With Flow Controller: A Review, Oluwaseyi O. Alabi, Adewale R. Inaolaji, Monsuru O. Mufutau

Al-Bahir

Wind turbines are vital to global renewable energy strategies, yet their aerodynamic performance often falls short of optimal levels, limiting overall efficiency and increasing operational loads. Flow controllers, devices designed to manipulate airflow around turbine blades, have emerged as a promising means of enhancing power capture while mitigating fatigue and structural stresses. This review presents a comprehensive synthesis of current research on aerodynamic optimization using flow controllers, covering both conventional and emerging technologies such as vortex generators, Gurney flaps, microtabs, and plasma actuators. The review evaluates the aerodynamic principles behind these devices, their reported performance improvements in laboratory and field …

Salicylic Acid Heterocyclic Derivatives: Chemical Synthesis And Biological Activity, Rawaa Hefdi Zaooli, Marwa Abdulameer Mseer, Amneen Mohammed Alsayegh

Al-Bahir

Before a drug can be widely used, it must go through a long development process, starting from the discovery of the active ingredient and continuing with tests to confirm its safety and effectiveness. In this study, new olsalazine derivatives were synthesized, containing a fused morpholine-3-one ring and two five-membered heterocyclic rings (thiadiazole and oxadiazole). Common and readily available materials, such as salicylic acid (to prepare 2-hydroxy-5-nitrobenzoic acid) and inexpensive catalysts, were used to synthesize compounds from the first, 5,5'-(diazene-1,2-diyl)bis(2-hydroxy-3-nitrobenzoic acid) (A1), to the seventh, 6,6'-(diazene-1,2-diyl)bis(N-(4-(5-amino-1,3,4-oxadiazol-2-yl)phenyl)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-8-carboxamide) (A7).

Each compound was characterized by FT-IR and ¹H-NMR spectroscopy, along with physical properties such …

Structure-Based Repurposing Of Clinically Approved Compounds For Pde-5 Inhibition: Integrative Computational And Pharmacokinetic Evaluation, Albashir Tahir, Yasir Idris Saleh, Ibrahim Khaleel Muazu

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences

Background: Phosphodiesterase-5 (PDE-5) regulates intracellular cyclic guanosine monophosphate (cGMP) levels, modulating vascular smooth muscle tone. Sildenafil, a well-established PDE-5 inhibitor, is effective for erectile dysfunction and pulmonary hypertension but causes dose-dependent adverse effects. Identifying alternative scaffolds with comparable efficacy and improved safety remains a pharmacological priority.

Methods: A ligand-based virtual screening of the DrugBank database was performed using sildenafil as a reference. Compounds exhibiting ≥60% structural and electrostatic similarity were docked into the PDE-5 catalytic domain (PDB ID: 2h42) using Glide XP in the Schrödinger Suite. Top-scoring ligands were assessed for physicochemical, pharmacokinetic (ADMET), and toxicity parameters using SwissADME and …

Design And Mechanistic Investigation Of Novel Metallodrugs: From Structure-Activity Relationships To Selective Cancer Cell Targeting, Samad Khaksar, Nosrat Behzadi, Hasan Zakeri Zakeri, Peyman Salahshour, Sara Abdolmaleki

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences

The relentless pursuit of alternatives to conventional platinum-based chemotherapeutics, hampered by severe side effects and drug resistance, defines a critical frontier in oncology drug discovery. This review consolidates and highlights the significance of our recent advances in designing novel metallodrugs based on pyridine-2,6-dicarboxylate derivatives coordinated with various metal ions (Ga(III), Ce(IV), Zn(II), Cu(II), Ni(II), Sr(II)). Through systematic synthesis and evaluation, we establish how strategic structural modifications dictate cytotoxicity, cellular uptake, and mechanistic pathways. Our comprehensive in vitro profiling across a panel of human cancer cell lines (including A431, SW480, BEL-7404) revealed potent anticancer activity, with IC50 values as low as …

Sphenocentrum Jollyanum: Pharmacological Insights Into A Neglected African Medicinal Plant, Albashir Tahir

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences

Sphenocentrum jollyanum Pierre (Menispermaceae) is a West African medicinal plant used traditionally for various ailments, including malaria, diabetes, and reproductive disorders. Despite its ethnobotanical significance, comprehensive scientific validation of its pharmacological properties remains limited. This review aims to provide a comprehensive overview of the plant’s ethnobotany, phytochemistry, and pharmacological activities, integrating traditional knowledge with modern scientific insights to guide future research. A comprehensive literature search was conducted in PubMed, ScienceDirect, Scopus, Google Scholar, and Web of Science, covering publications up to April 2025. Search terms included "Sphenocentrum jollyanum", "ethnobotanical use", "pharmacological effects", and related keywords. Relevant articles were screened, and …

Green Pharmaceutical Systems: Alpha-Tocopherol Encapsulation In Nanostructured Lipid Carriers Via Microwaves-Based Technique As Advanced Topical Drug Delivery Systems, Hayder Kadhim Drais, Mohammed A Albarki, Hayder Ridha-Salman, Ahmed Abbas Hussein, Ashraf Abbas Drais

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences

Alpha tocopherol (Vitamin E) is practically insoluble in water. It is important for skin health due to its many therapeutic actions, such as antioxidant, anti-inflammatory, and photoprotection. Therefore, the purpose of this study is to develop, prepare, and evaluate nanostructured lipid carriers (NLCs)-based hydrogels as a topical dosage form to improve stability and therapeutic activity of vitamin E. The microwave-based method prepared five lavender oil-based NLCs (LN1–LN5) formulations that were assessed thermodynamically and entered into characterization processes. Hydrogels formulations based on NLCs (LNG1–LNG5) were prepared and evaluated. All of the lavender oil-based NLC formulations (LN1–LN5) had suitable surface charge, a …

History And Prevention Of Foot-And-Mouth Disease Virus In Iraq: A Review, Ashwaq M. S. Al-Jbouri, Baraa Hamid Hadi, Saad Mardi Muhammad, Raoof J. A. Maaroof, Nada Khazal K. Hindi, Karrar Kamoona, Zainab Ayad, Rusul Ahmed Mohammed

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences

Foot-and-mouth disease Virus (FMDV) is an extremely transmittable viral illness that affects cloven-hoofed faunae, such as cattle, goats, sheep, and pigs. This study aimed to demonstrate the history and prevention of foot-and-mouth disease (FMD) in Iraq. This virus poses a significant threat to the economy, necessitating strict measures to control and prevent its spread, particularly due to its high morbidity and mortality rates, especially in young faunae. It is one of the most contagious diseases as it is transmitted directly or indirectly from a diseased fauna to a healthy one through contact with resources contaminated with the virus, such as …

From Dreamberries Swirling In My Tongue, Michael Balili

Kritika Kultura

No abstract provided.

Full Issue, Kritika Kultura

Kritika Kultura

No abstract provided.

Three Poems, Allan Justo Pastrana

Kritika Kultura

No abstract provided.

Bagong Dating, Efmer E. Agustin

Kritika Kultura

No abstract provided.