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Articles 43201 - 43230 of 1738631
Full-Text Articles in Entire DC Network
Virginia Dental Journal Announces Excellence Awards - Call For Submissions, Shannon Jacobs
Virginia Dental Journal Announces Excellence Awards - Call For Submissions, Shannon Jacobs
Virginia Dental Journal
The Virginia Dental Journal is introducing the Excellence Awards in 2026 to honor outstanding contributions in writing, clinical relevance, and advancing the dental profession in Virginia. Articles published in Volume 103 (2026) are eligible, with submissions due by September 1, 2026. Award categories include the Horizon Award, Image Award, The Source Award, and Editor’s Choice. Winners will be recognized at the Virginia Dental Association’s Annual Business Meeting in January 2027. More details and guidelines are available on the Virginia Dental Journal website.
Va Dent J January, February And March 2026
Va Dent J January, February And March 2026
Virginia Dental Journal
The January-March 2026 issue of the Virginia Dental Journal highlights key updates and initiatives from the Virginia Dental Association (VDA). It addresses Virginia’s dental workforce shortage with a proposed three-step legislative solution to expand access to care and strengthen the dental workforce pipeline. The issue features upcoming events, including the VDA Legislative Reception, Lobby Day, and the Virginia Dental Showcase. It also provides educational opportunities, such as the Dental Assisting II Program and the Virginia Dental Journal Excellence Awards. Advocacy updates focus on legislative efforts, Medicaid budget cuts, and AI regulations in dentistry. Resources for members include discounts through VDA …
A Case Study Of Faculty Composition And Workload In Sport Management Programs At Small-To-Medium-Sized Colleges And Universities, Joshua Greer, Nicholas Zoroya, Aimee T. Vlachos, Alan Ledford
A Case Study Of Faculty Composition And Workload In Sport Management Programs At Small-To-Medium-Sized Colleges And Universities, Joshua Greer, Nicholas Zoroya, Aimee T. Vlachos, Alan Ledford
The COSMA Journal
Sport management has transitioned from its origins in physical education to an established, business-oriented academic discipline, prompting new questions about how faculty composition and workload shape program delivery in resource-constrained contexts. This case study investigates faculty structures, instructional variety, and workload in sport management programs at small- to medium-sized U.S. colleges and universities, as defined by the Carnegie Size & Setting Classification. A mixed-methods survey of faculty (n = 61) was analyzed using descriptive statistics and thematic content analysis. Quantitative results indicated that core courses are primarily taught by full-time faculty, with most programs relying on one to three full-time …
The Archon, December 1948, Zeta Phi Beta Sorority Incorporated
The Archon, December 1948, Zeta Phi Beta Sorority Incorporated
Josie Green Washington Papers
A pamphlet called The Archon, an official organ of the Zeta Phi Beta Sorority, from December 1948.
Ibn Malik’S Approach To Grammatical Evidence A Reading Of The Arguments Of Supporters And Opponents, Asst. Prof. Mousa Bin Nasser Al-Mousa
Ibn Malik’S Approach To Grammatical Evidence A Reading Of The Arguments Of Supporters And Opponents, Asst. Prof. Mousa Bin Nasser Al-Mousa
UB Journal for Humanities
his study examines, on one hand, the evidence advanced by those who accuse Ibn Mālik of fabricating grammatical citations (shawāhid), and, on the other, the evidence and rejoinders offered by those who hold him innocent of such fabrication. The researcher adopts an inductive method by tracing the arguments of both the affirmers and the deniers, analyzing them, and then evaluating them in an effort to reach a preponderant judgment on the question. The findings indicate the strength and cogency of the two principal proofs: solitary transmission (tafarrud) and omission of attribution (ighfāl al-nisba), as well as the inability of the …
Indian Neighbours In Medina From The 11th To 13th Hijri Century / 17th To 19th Gregorian Century, Dr. Samia Suliman Al-Jabry
Indian Neighbours In Medina From The 11th To 13th Hijri Century / 17th To 19th Gregorian Century, Dr. Samia Suliman Al-Jabry
UB Journal for Humanities
This study explores the dimensions of Indian Muslims’ migration to Medina, From the eleventh century AH to the thirteenth century AH / the seventeenth to the nineteenth century CE. shedding light on the city’s status as a religious and intellectual hub that attracted residents from across the Islamic world. It demonstrates how the concept of mujawara (settling near the Prophet’s Mosque), initially intended as a temporary stay, evolved into a multifaceted civilizational phenomenon. Indian Muslims played a significant role in stimulating the intellectual, economic, and social life of Medina. The study also highlights their contribution to building a web of …
Dialectical Techniques And Logical And Psychological Critiques In The Work Of Imam Al-Tufi: An Analytical Study Of 'Commentary On The Four Gospels And The Twelve Books' From A Jurisprudential Perspective, Dr. Reema Bint Ali Muhammad Al-Qahtani
Dialectical Techniques And Logical And Psychological Critiques In The Work Of Imam Al-Tufi: An Analytical Study Of 'Commentary On The Four Gospels And The Twelve Books' From A Jurisprudential Perspective, Dr. Reema Bint Ali Muhammad Al-Qahtani
UB Journal for Humanities
This study examines the dialectical methods and logical fallacies employed by Imam al-Ṭūfī in his refutation of the Christians through his work al-Taʿlīq ʿalā al-Anājīl al-Arbaʿa wa-al-Kutub al-Ithnay ʿAshar. The research seeks to identify the types of dialectical fallacies extracted by the Imam and to explain how he employed them in defending Islamic creed and refuting the claims of his opponents with a solid rational methodology, rendering his work worthy of scholarly attention from both uṣūlī (legal-theoretical) and dialectical perspectives. The study adopts an inductive method first, followed by deductive and analytical approaches. Among its key findings is that Imam …
Atmospheric Waves Experiment (Awe) Thermal Control System: Review Of On-Orbit Performance, Matthew I. Ralphs, Mike Holt
Atmospheric Waves Experiment (Awe) Thermal Control System: Review Of On-Orbit Performance, Matthew I. Ralphs, Mike Holt
Space Dynamics Laboratory Publications
This paper reviews the Atmospheric Waves Experiment (AWE) detector thermal control system’s (TCS) performance for over two years of operation on the Internation Space Station (ISS). The TCS employs active thermal control for the InGaAs detectors with thermoelectric coolers (TEC). Each of the four detectors are controlled by a dedicated TEC at a nominal setpoint of -30°C, with heat transported away via low-mass, high-conductance pyrolytic graphite sheet (PGS) thermal straps into a nickel-plated copper conductor bar. A bi-directional radiator with Silver Teflon ensures an unobstructed view that can radiate the heat away to space. Titanium isolators decouple the detectors from …
A Suite Of Thermal Switches For Surviving Extreme Thermal Environments In Space, Matthew I. Ralphs, Matt Jensen, Alexis Eames, Matt Sinfield
A Suite Of Thermal Switches For Surviving Extreme Thermal Environments In Space, Matthew I. Ralphs, Matt Jensen, Alexis Eames, Matt Sinfield
Space Dynamics Laboratory Publications
Thermal switches are a key enabling technology for spacecraft operating in extreme thermal environments. Whether surviving the lunar night, managing intermittent high-power loads from deep space communication systems, or dealing with other extreme thermal environments, high-performance thermal switches allow critical missions to operate beyond conventional thermal design limits. This paper presents the development, testing, and performance of a suite of passive thermal switches designed for both spacecraft- and subsystem-level thermal control. The suite includes: (1) traditional in-line switch placed between sensitive components and radiators; (2) compact designs suitable for integration into standard bolted joint interfaces to modulate the conductance between …
Hypersonic Non-Equilibrium Cfd And Dsmc Model Comparisons With The Varda Reentry Capsule, Jack D. Crespo, Paolo Valentini, Ashwin P. Rao, Zach S. Davis
Hypersonic Non-Equilibrium Cfd And Dsmc Model Comparisons With The Varda Reentry Capsule, Jack D. Crespo, Paolo Valentini, Ashwin P. Rao, Zach S. Davis
Space Dynamics Laboratory Publications
Nonequilibrium aerothermodynamic modeling of the Varda hypersonic testbed capsule is conducted with direct simulation Monte Carlo (DSMC) and computational fluid dynamics (CFD) solvers. Flowfield properties at the 78 km reentry trajectory point are extracted to compute line of sight spectral radiance using two radiative emission codes, namely HARA and NEQAIR. Computed spectra are compared to spectral radiance measured by an in situ optical emission spectroscopy payload flown on Varda’s W-2 capsule in 2025. Model comparisons to the experimental data reveal discrepancies between the HARA and NEQAIR radiative emission predictions in both overall magnitude and qualitative behavior. NEQAIR was found to …
Oer Textbook Review For Human Inheritance - Chromosomes, Genes, And Traits - An Introduction To Genetics, Maria Lazebnik
Oer Textbook Review For Human Inheritance - Chromosomes, Genes, And Traits - An Introduction To Genetics, Maria Lazebnik
Open Educational Resources Publications
This review evaluates the adoption and classroom integration of the open educational resource Chromosomes, Genes, and Traits: An Introduction to Genetics for NAS322: Human Inheritance. The instructor found the OER to be comprehensive, accurate, and well aligned with core human genetics concepts, though some content areas—particularly mutations and certain visual diagrams—required supplementation or revision. The flexibility of the OER allowed for significant reorganization, modular use, and removal of non-human examples to better suit course objectives. Integration into Brightspace improved accessibility, reduced student confusion around textbook requirements, and enhanced engagement through direct linking and built-in quizzes. Compared to the previously used …
Educational Policies Committee Agenda January 8, 2026, Utah State University
Educational Policies Committee Agenda January 8, 2026, Utah State University
Educational Policies Committee
- Approval of Minutes - December 4, 2025
- Subcommittee Reports
- Curriculum Subcommittee
- Academic Standards Subcommittee
- General Education Subcommittee
- Other Business
- Adjourn: 4:00 pm
Curriculum Subcommittee Agenda January 8, 2026, Utah State University
Curriculum Subcommittee Agenda January 8, 2026, Utah State University
Educational Policies Committee
- Approval of Minutes - December 4, 2025
- R401 - Program Proposals
- Semester Course Approval Reviews
- Other Business
- UCC and EPC Handbook updates
- Adjourn: 3:00 pm
Regional Anesthesia Utilizing Liposomal Bupivacaine, With Or Without Dexamethasone, Provides Excellent Pain Control And Minimizes Opioid Consumption Following Anterior Cruciate Ligament Reconstruction, William L. Johns, Armen Voskeridjian, Benjamin Miltenberg, Rahul Muchintala, Christopher C. Dodson, Steven B. Cohen, John Salvo, Matthew Sherman, Michael G. Ciccotti, Sommer Hammoud
Regional Anesthesia Utilizing Liposomal Bupivacaine, With Or Without Dexamethasone, Provides Excellent Pain Control And Minimizes Opioid Consumption Following Anterior Cruciate Ligament Reconstruction, William L. Johns, Armen Voskeridjian, Benjamin Miltenberg, Rahul Muchintala, Christopher C. Dodson, Steven B. Cohen, John Salvo, Matthew Sherman, Michael G. Ciccotti, Sommer Hammoud
Rothman Institute Papers
BACKGROUND: Perioperative nerve blocks are commonly used for regional analgesia with anterior cruciate ligament (ACL) reconstruction (ACLR). Liposomal bupivacaine (LB) is a long-acting anesthetic agent providing up to 72 hours of nerve blockade. It is theorized that the addition of dexamethasone to LB (LB+dex) may prolong the analgesic duration.
PURPOSE: To characterize pain control and opioid consumption with adductor canal block (ACB), interspace between the popliteal artery and capsule of the posterior knee (iPACK), and suprasartorial infiltration (SSI) regional anesthetic techniques utilizing LB after ACLR and to compare LB versus LB+dex.
STUDY DESIGN: Randomized controlled trial; Level of evidence, 1. …
What’S My Name? Experiences Of Individuals With Traditional Hawaiian Names, Natalya N. Spotkaeff
What’S My Name? Experiences Of Individuals With Traditional Hawaiian Names, Natalya N. Spotkaeff
Walden Dissertations and Doctoral Studies
There is no systematic process of orienting non-Hawaiian educators to Hawaiian culture, as evidenced by name mispronunciation. The purpose of this phenomenological study was to explore the experiences of individuals with traditional Hawaiian first names in a classroom environment. Critical race theory (CRT), especially the concept of microaggressions, was used as the framework for the study. Two research questions guided the study: What are the adult lived experiences with traditional Hawaiian first names encountered in academic settings during childhood? How do adults with traditional Hawaiian first names describe their experiences of race in the classroom? Semistructured interviews were conducted with …
A Comparative Analysis Of Rural And Urban Mental Health Counselors’ Burnout Levels During The Covid-19 Pandemic, Pietro Martucci
A Comparative Analysis Of Rural And Urban Mental Health Counselors’ Burnout Levels During The Covid-19 Pandemic, Pietro Martucci
Walden Dissertations and Doctoral Studies
The COVID-19 pandemic substantially increased occupational demands on mental health counselors, intensifying burnout and threatening clinician well-being, workforce sustainability, and quality of care. Guided by Resiliency Theory, this quantitative cross-sectional study examined burnout among rural and urban mental health counselors during the COVID-19 pandemic, with geographic location serving as the independent variable. Participants included 108 licensed master’s- and doctoral-level counselors in the United States who provided direct clinical services in rural or urban settings between March 1, 2020, and March 1, 2021. Data were collected using an online survey that included a demographic questionnaire and the Maslach Burnout Inventory–Human Services …
The Relationship Between Cloud Computing Factors And Cloud Computing Behavioral Intention Of First-Year University Students, Gabriel Albino
The Relationship Between Cloud Computing Factors And Cloud Computing Behavioral Intention Of First-Year University Students, Gabriel Albino
Walden Dissertations and Doctoral Studies
In an era where vast amounts of data are generated daily, the ability to manage information through cloud computing has become critical; however, asymmetries in using this technology persist, particularly in developing countries. Academic managers often lack information about the factors influencing cloud computing usage. The purpose of this quantitative correlational cross-sectional study was to examine the relationship between cloud computing factors, including effort expectancy (EE), performance expectancy (PE), social influence (SI), and facilitating conditions (FC), and the first-year university students’ cloud computing behavioral intention (CCBI) in the developing country of Angola. A structured questionnaire was administered to a random …
A Phenomenological Exploration Of Lgbtq+ High School Graduates’ Perspectives On Lgbtq+-Related Legislation, Thomas James Foley
A Phenomenological Exploration Of Lgbtq+ High School Graduates’ Perspectives On Lgbtq+-Related Legislation, Thomas James Foley
Walden Dissertations and Doctoral Studies
Lesbian, gay, bisexual, transgender, queer, and questioning (LGBTQ+) students’ social, emotional, and academic experiences and outcomes are not on par with their non-LGBTQ+ peers. Understanding how LGBTQ+ young adults experienced high school in a state with LGBTQ+-affirmative education legislation provides insight for counselors and educators to identify policies and practices that support positive outcomes for LGBTQ+ students. This qualitative phenomenological study explored how LGBTQ+-identifying high school graduates made meaning of their experiences in school as they related to LGBTQ+-affirmative education legislation. Interpretive phenomenological analysis (IPA) was used for the research methodology and data analysis process. Results included four themes: (a) …
Ga4gh Phenopacket-Driven Characterization Of Genotype-Phenotype Correlations In Mendelian Disorders., Lauren Rekerle, Daniel Danis, Filip Rehburg, Adam S L Graefe, Viktor Bily, Andrés Caballero-Oteyza, Pilar Cacheiro, Leonardo Chimirri, Jessica X Chong, Evan Connelly, Bert B A De Vries, Alexander J M Dingemans, Michael H Duyzend, Tomas Freiberger, Petra Gehle, Tudor Groza, Peter Hansen, Julius O B Jacobsen, Adam Klocperk, Markus S Ladewig, Michael I Love, Allison J Marcello, Alexander Mordhorst, Monica C Munoz-Torres, Justin Reese, Catharina Schuetz, Damian Smedley, Timmy Strauss, Ondrej Vladyka, David Zocche, Sylvia Thun, Christopher J Mungall, Melissa A Haendel, Peter N Robinson
Ga4gh Phenopacket-Driven Characterization Of Genotype-Phenotype Correlations In Mendelian Disorders., Lauren Rekerle, Daniel Danis, Filip Rehburg, Adam S L Graefe, Viktor Bily, Andrés Caballero-Oteyza, Pilar Cacheiro, Leonardo Chimirri, Jessica X Chong, Evan Connelly, Bert B A De Vries, Alexander J M Dingemans, Michael H Duyzend, Tomas Freiberger, Petra Gehle, Tudor Groza, Peter Hansen, Julius O B Jacobsen, Adam Klocperk, Markus S Ladewig, Michael I Love, Allison J Marcello, Alexander Mordhorst, Monica C Munoz-Torres, Justin Reese, Catharina Schuetz, Damian Smedley, Timmy Strauss, Ondrej Vladyka, David Zocche, Sylvia Thun, Christopher J Mungall, Melissa A Haendel, Peter N Robinson
Faculty Research 2026
Comprehensively characterizing genotype-phenotype correlations (GPCs) in Mendelian disease would create new opportunities for improving clinical management and understanding disease biology. However, heterogeneous approaches to data sharing, reuse, and analysis have hindered progress in the field. We developed Genotype-Phenotype Statistical Evaluation of Associations (GPSEA), a software package that leverages the Global Alliance for Genomics and Health (GA4GH) Phenopacket Schema to represent case-level clinical and genetic data about individuals. GPSEA applies an independent filtering strategy to boost statistical power to detect categorical GPCs represented by Human Phenotype Ontology terms. GPSEA additionally enables visualization and analysis of continuous phenotypes, clinical severity scores, and …
Death Of Substantiality: Why The Legal System Should Rethink The Application And Weight Of This Fair-Use Factor In The Context Of Social Media, Lindsey Vickers
Death Of Substantiality: Why The Legal System Should Rethink The Application And Weight Of This Fair-Use Factor In The Context Of Social Media, Lindsey Vickers
Washington Journal of Law, Technology & Arts
The fair use test for exemption for liability from copyright infringement was codified in the 1970s and has not been updated since—despite major technological changes in the interim. While three of the test’s four prongs are still useful when applied to short-form media that now dominates worldwide media consumption, the factor that considers the substantiality of the portion used relative to the total work is obsolete. The current dysfunctionality of this prong in social media settings is not the only reason it should be reassessed by courts and Congress. The prong and its analysis are a bit of a Frankenstein. …
Fluid Agency In Ai Systems: A Case For Functional Equivalence In Copyright, Patent, And Tort, Anirban Mukherjee, Hannah H. Chang
Fluid Agency In Ai Systems: A Case For Functional Equivalence In Copyright, Patent, And Tort, Anirban Mukherjee, Hannah H. Chang
Washington Journal of Law, Technology & Arts
Modern artificial intelligence (AI) systems lack human-like consciousness or culpability, yet they exhibit fluid agency: behavior that is (i) stochastic (probabilistic and path-dependent), (ii) dynamic (co-evolving with user interaction), and (iii) adaptive (able to reorient across contexts). Fluid agency generates valuable outputs but collapses attribution, irreducibly entangling human and machine inputs. This fundamental unmappability fractures doctrines that assume traceable provenance—authorship, inventorship, and liability—yielding ownership gaps and moral “crumple zones.”
This Article argues that only functional equivalence stabilizes doctrine. Where provenance is indeterminate, legal frameworks must treat human and AI contributions as equivalent for allocating rights and responsibility—not as a claim …
Fiscal Sponsorship In Truly Independent Film: Entity And Model Choice And Legal Risks, Samuel Johnson
Fiscal Sponsorship In Truly Independent Film: Entity And Model Choice And Legal Risks, Samuel Johnson
Washington Journal of Law, Technology & Arts
This article examines fiscal sponsorship as a legal and financing structure for “truly independent” films—low-budget, non-commercial projects created by filmmakers without access to studio financing, tax incentives, or traditional investors. Neither standalone nonprofit incorporation nor purely for-profit entity structures adequately address the unique needs of such projects. After surveying the development of fiscal sponsorship as a means of funding projects that meet an exempt purpose, relevant IRS guidance, and current prevailing practices and organizational structures in independent film, the article contends that a Model C (“regranting”) fiscal sponsorship paired with a single-member limited liability company (SMLLC) offers the optimal balance …
Creating A Scorecard—The Case Of How Well Texas Four-Year, Public Universities Serve Texas Latinos?, Arturo Vega
Creating A Scorecard—The Case Of How Well Texas Four-Year, Public Universities Serve Texas Latinos?, Arturo Vega
Public Administration Scholarship and Projects
The goal of this inaugural “How-to Working Paper” is to provide a resource to measure performance, effectiveness or simply the underlying dimensions of a concept, perception or attitude. This paper focuses on how to create and use a scorecard or index. The principal audience of these “How-to Working Papers” are upper-level social science disciplines like political science or sociology and master-level graduate students in, again, political science or public administration. But really any university student or civically-minded individual conducting research will benefit from this paper.
Oer Review For Business & Society – Ai Generated Oer Supplements And Open Pedagogy Assignment: Undergraduate Perspectives On Responsible Business, Cynthia E. Clark Ph.D
Oer Review For Business & Society – Ai Generated Oer Supplements And Open Pedagogy Assignment: Undergraduate Perspectives On Responsible Business, Cynthia E. Clark Ph.D
Open Educational Resources Publications
This review examines the integration of open educational resources and open pedagogy in Business & Society (MG 313), where students engaged in both AI‑supported research and authorship to create the open textbook Undergraduate Perspectives on Responsible Business. The project combined open access materials, AI‑generated readable adaptations of scholarly articles, and a redesigned Position Paper assignment that invited students to contribute their work to a public Pressbooks publication. These activities strengthened student engagement, improved comprehension of responsible business perspectives, and expanded access to course materials. The iterative use of OER, alongside guest instruction and library support, fostered deeper student ownership …
Multidisciplinary Approach To Reducing Healthcare-Associated Infections: A Dnp Project, Jovinsky Jonaldo Eliscard
Multidisciplinary Approach To Reducing Healthcare-Associated Infections: A Dnp Project, Jovinsky Jonaldo Eliscard
Walden Dissertations and Doctoral Studies
Healthcare-associated infections are increasingly common in healthcare facilities due to multiple concerns, including negligence, human error, and poor conditions. According to Chuwa (2024), secondary infections are a significant threat to patient safety and wellness, reducing an organization’s ability to realize clinical objectives. The facility is a large healthcare provider operating numerous hospitals and care homes across the United States. The organization continues to report increased infection rates across its branches owing to a lack of standardized infection prevention and control protocols, reducing its efficiency and appeal. Internal audits point to inconsistencies in general sanitation, cleanliness, and hygiene. The organization also …
Analysis Of The Determinants Of Cash Holdings And The Implications For Local Government Spending Effectiveness In West Java, Ismail Marzuki Randos, Nia Suciyati
Analysis Of The Determinants Of Cash Holdings And The Implications For Local Government Spending Effectiveness In West Java, Ismail Marzuki Randos, Nia Suciyati
Journal of Accounting Auditing and Business
Cash management is fundamental to sustaining uninterrupted local service delivery and supporting credible budget execution. In West Java, municipal cash holdings exhibited fluctuations over 2019–2023, with only a limited number of districts/cities consistently maintaining cash holdings ratios above the operational sufficiency threshold. This study examines (i) the determinants of cash holdings Capacity and (ii) the relationship between cash holdings and expenditure effectiveness. Cash Holdings Capacity is classified as sufficient when the cash holdings ratio exceeds 100%, whereas Expenditure Effectiveness is classified as effective when the effectiveness ratio exceeds 90%. The quantitative analysis applies binary logistic regression to 27 districts/cities in …
Transmission Of Geopolitical Shocks To Firm Behavior: A Synthesis And Integrative Model, Daniel S. Andrews, Harald Puhr, April Knill
Transmission Of Geopolitical Shocks To Firm Behavior: A Synthesis And Integrative Model, Daniel S. Andrews, Harald Puhr, April Knill
Faculty Publications
This study examines the transmission of geopolitical shocks to firm behavior. While previous research has primarily focused on the direct relation between shocks and firm behavior, we provide a more nuanced understanding by conceptualizing geopolitical shocks as disruptions that evolve through explicit and implicit channels to influence firm behavior. Based on a systematic review of 159 articles, we identify the key mechanisms that transmit the impacts of a geopolitical shock. Our findings reveal that geopolitical shocks manifest in institutions and their lower-level mechanisms, and such transmission is neither uniform nor random. Furthermore, we categorize firm behavior into distinct response modalities. …
Fibrinogen-Associated Plasma Metabolites And Implications For Coagulation, Inflammation, And Vascular Diseases, Jayna C Nicholas, Taryn Alkis, Joshua C Bis, Eric Boerwinkle, Jennifer A Brody, Clary B Clish, Paul S De Vries, Yan Gao, Robert E Gerzsten, Xiuqing Guo, Andrew D Johnson, Martin G Larson, Rozenn N Lemaitre, Bruce M Psaty, Vasan Ramachandran, Alexander P Reiner, Stephen S Rich, Benjamin Rodriguez, Jian Rong, Jerome I Rotter, Jeanette Simino, Nicholas L Smith, James Wilson, Jie Yao, Alanna C Morrison, Bing Yu, Laura M Raffield
Fibrinogen-Associated Plasma Metabolites And Implications For Coagulation, Inflammation, And Vascular Diseases, Jayna C Nicholas, Taryn Alkis, Joshua C Bis, Eric Boerwinkle, Jennifer A Brody, Clary B Clish, Paul S De Vries, Yan Gao, Robert E Gerzsten, Xiuqing Guo, Andrew D Johnson, Martin G Larson, Rozenn N Lemaitre, Bruce M Psaty, Vasan Ramachandran, Alexander P Reiner, Stephen S Rich, Benjamin Rodriguez, Jian Rong, Jerome I Rotter, Jeanette Simino, Nicholas L Smith, James Wilson, Jie Yao, Alanna C Morrison, Bing Yu, Laura M Raffield
Faculty, Staff and Student Publications
Background: Fibrinogen is a critical coagulation factor that plays an essential role in thrombosis and is elevated in individuals with chronic inflammation. Here, we used fibrinogen as a representative quantitative measure of pro-coagulant risk and evaluated metabolites associated with fibrinogen levels through non-targeted plasma metabolomic profiling (Broad and Metabolon platforms).
Methods: Our analysis included 10,533 individuals across six U.S. based cohorts representing diverse population groups. The cross-sectional relationship between each of 789 tested metabolites and plasma fibrinogen concentration was assessed with adjustment for relevant covariates such as age, sex, body mass index, and circulating lipoprotein levels.
Results: Meta-analysis of per-cohort …