Digital Commons Network^™

Knockdown Of Tyrosine Kinase Receptor Fgfr1 Via Azd4547 Suppresses Breast Cancer Proliferation, Migration, And Invasion In Brca1 Mutant Adipose-Derived Stem Cells (Ascs) Via Il-6 And Tnf-Α Modulation, Nahid Sabah Aldin Saber, Zahraa Ali Mohammed

Baghdad Science Journal

Breast cancer is a complex heterogeneous disease that poses significant challenges in identifying novel therapeutic strategies and new therapeutic targets. Recent research has identified adipose-derived stem cells (ASCs) role in the progression of small tumors. Mutations in Breast Cancer gene 1 (BRCA1) are known to play a crucial role in DNA repair and cell cycle regulation. BRCA1 mutations have been associated with increased risks of breast and ovarian cancer. Moreover, studies have shown that Fibroblast Growth Factor Receptor 1 (FGFR1) is involved in initiation of many cancers, including breast cancer. In the present study, we aim to investigate the role …

Quantitative Analysis Of Thiamine, Riboflavin, And Niacin Vitamins By High-Performance Liquid Chromatography In Pharmaceutical Sample Tablets And Drops, Sarra A. Abrahem, Suhad A. Ibrahim, Alaa Sh. Abdulbari, Noor M. Ali, Maryam Y. Hashim

Baghdad Science Journal

Levering cutting-edge high-performance liquid chromatography techniques with a C-18 column, we meticulously crafted a gradient of MeOH and glacial CH₃COOH (96–5%), pulsating through at a mesmerizing 1.2 ml/min. With ultraviolet detection at a precise wavelength of 245 nm, we unraveled the mysteries of these vital nutrients. Thiamine reveals itself at a retention time of 3.5 min, followed by Riboflavin at 8.1 min and Niacin at 10.8 min. The findings of this study were not just a spectacle of scientific powers but were also rigorously benchmarked against commercial drugs, ensuring accuracy and reliability in our analysis.

Studying The Level Of Amyloid-A And Fibrinogen-Like Protein 1 And Other Biomarkers In The Sera Of Rheumatoid Arthritis Of Iraqi Patients, Aya Waleed Aziz, Bushra Faris Hasan

Baghdad Science Journal

Rheumatoid arthritis (RA) isa common chronic autoimmune disease characterized by synovitis causing pain and inflammation and can result in joint destruction, its risk factors involve a family history of disease, obesity, smoking as well as viral infections. In this study, serum amyloid A and fibrinogen-like protein 1 were evaluated in 80 patients and 40 healthy controls (both men and women). Measurement of SAA, FGL1, RF, CRP, and MPO were performed using ELISA kits, the colorimetric method has been employed for estimating lipid profile, and Westergren method has used to measure ESR. The results indicated that levels of SAA, FGL1, MPO, …

Determination Of Trace Pyridoxine Hydrochloride (Vitamin B6) In Dosage Forms And Redbull Samples Using Dispersive Liquid-Liquid Microextraction Technique Coupled With Spectrophotometry, Sally Ghanem Ahmed, Wijdan Shakir Khayoon

Baghdad Science Journal

This paper introduced a sensitive determination method measurement spectrophotometric coupled with dispersive liquid-liquid micro extraction based on charge transfer complex formation between pyridoxine hydrochloride and chloranil using alkaline buffer (pH = 10.5). After that, the extraction of charge transfer complex was conducted by injection a mixture of chloroform and acetone solvents followed by spectrophotometric measurement of tiny organic droplets at λ = 535 nm. The important parameters affecting the formation of the complex and efficiency of DLLME such as concentration of chloranil, volume and pH of buffer solution, reaction time and the optimum conditions of DLLME has been studied and …

First Record Of Keratitis Caused By Valkampfia In Iraq, Turkan K. Karyagdi

Baghdad Science Journal

Acanthamoeba is the most well-known causes amoebic keratitis. However, other free-living amoebas (FLA), such as Valkampfia, can also causes of keratitis. Twenty-two samples were collected from cases suspected of amoebic keratitis in Kirkuk Hospital to investigate the presence of Acanthamoeba . Cultivation process was carried out directly on non-nutrient agar (NNA) medium supported with killed Escherichia coli bacteria. Inverted and light microscope were used at 40X magnification to diagnose cultures growth .Only two samples showed positive growth on NNA medium. However, no any presence of Acanthamoeba was observed as were expected using polymerase chain reaction (PCR) which ampilified by …

Distribution Of Some Antibiotic Resistance Genes Among Carbapenem-Resistant Acinetobacter Baumannii Isolated From Patients Lying Icu In Al-Najaf /Iraq, Ghufran Rajab Taher, Ahlam Kadhim Alyasseen

Baghdad Science Journal

Acinetobacter baumannii is a significant nosocomial pathogen, affecting immunocompromised and critically ill patients in intensive care units (ICUs). The emergence of carbapenem-resistant A. baumannii (CRAB) poses a threat due to its resistance to multiple antibiotics. This study investigates the prevalence of carbapenemase-encoding genes among CRAB isolates from ICU patients at AL-Sadder hospital/ Najaf. Eight sputum specimens were collected from ICU patients suspected of A. baumannii. The isolates were identified through morphological, biochemical tests and the Vitek 2 Compact system. Antibiotic sensitivity was determined by the Vitek 2 Compact system (using AST card). only 5 A. baumannii isolates have been …

Protective Effect Of Boswellia Carterii And Gum Arabic (Senegalia Senegal) On Induced Arthritic In Male Rats, Basma Ali Jasim, Alia Hussein Ali

Baghdad Science Journal

The study aims to use natural substances like Senegalia senegal and Boswellia carterii to treat rheumatoid arthritis, a painful disease affecting joints and making movement difficult, , The two plants were used to treat the symptoms of induced arthritis in male rats by using the complete freund's adjuvant method. A group of thirty adult male rats was used in this study, divided into six groups, with five rats for each group. The 1st group was the negative control (without arthritis induced and without treatment); the 2nd group is the positive control group (with arthritis induced and without any treatment); the …

Pre-Operative Methicillin-Resistant Staphylococcus Aureus Colonization Increases The Risk Of 90-Day Medical And 2-Year Implant-Related Complications Following Primary Total Shoulder Arthroplasty: A Propensity-Matched Analysis, Muhammad Hamza Ilyas, Tarishi Parmar, Zina Smadi, Viraj A. Deshpande, Akin A. Adio, Joseph A. Abboud, Hafiz F. Kassam

Rothman Institute Papers

BACKGROUND: Pre-operative methicillin-resistant Staphylococcus aureus (MRSA) colonization has been associated with increased risk of post-operative infection and medical complications in lower-extremity arthroplasty; however, its impact on outcomes following total shoulder arthroplasty (TSA) remains poorly understood. This study aims to evaluate the association between MRSA colonization and early medical as well as mid-term implant-related complications after primary TSA.

METHODS: The TriNetX US Research Network was queried to identify primary TSA patients. Propensity score matching (1:1) was performed using demographic characteristics and relevant comorbidities. Ninety-day medical complications, including readmission, emergency department utilization, venous thromboembolism, pneumonia, urinary tract infection, stroke, sepsis, respiratory failure, …

Epidemiology And Follow-Up Adherence Of Ophthalmic Emergencies: A 10-Year Study At A Tertiary Medical Center In Taiwan, Tsung-Ying Tsai, Chunya Kang, Laura Liu, Nan-Kai Wang, Kuan-Jen Chen, Wei-Chi Wu, Chi-Chun Lai, Sunir J. Garg, Eugene Yu-Chuan Kang, Yih-Shiou Hwang

Wills Eye Hospital Papers

PURPOSE: The purpose of the study was to evaluate factors influencing outpatient follow-up adherence among patients receiving ophthalmology consultations in the emergency department (ED).

MATERIALS AND METHODS: This retrospective cohort study collected data from the Chang Gung Research Database. Patients who received ophthalmology consultations at the ED of Chang Gung Memorial Hospital Linkou Medical Center from January 1, 2010, to December 31, 2019, were included. Patients were divided into two groups based on whether they completed outpatient follow-up within 28 days, a timeframe consistent with our hospital's scheduling policy. Demographics, ED visit timing, triage categories, ophthalmic diagnoses, prior visits, and …

Pressed For Time: The Role Of Time Pressure And Attentional Awareness On The Mental Health Of Employed Informal Dementia Caregivers, Kate Bishop

University Honors Theses

Informal caregivers for individuals with Alzheimer’s and related dementias (ADRD) experience increased time demands and poorer well-being, especially when caregiving is combined with paid employment. Subjective feelings of high time pressure, which include feeling rushed and short on time, relate to poorer self-reported measures of mental health more than objective task load. Attentional awareness is one of the fundamental components of mindfulness alongside nonjudgmental acceptance; it has been linked with more optimal mental health and feelings of having enough time. This cross-sectional study examined whether higher levels of perceived time pressure would relate to poorer self-reported mental health functioning and …

European Geosciences Union Honors Bianchi, Unh Communications And Public Affairs

UNH Today Archive

No abstract provided.

Science And Technology Communication And Construction Of China’S International Discourse System: Strategic Significance, Current Challenges, And Innovative Pathways, Haonan Du, Ting Wang

Bulletin of Chinese Academy of Sciences (Chinese Version)

Against the backdrop of a new round of scientific and technological revolution with the ongoing restructuring of the global governance system, science and technology have become central to competition in national comprehensive competitiveness and struggles for international discourse power. China’s science and technology have achieved a historic leap from “catching up” to “running alongside” and even “leading in certain areas”, providing solid strength support for the construction of an international discourse system. However, the transformation of scientific and technological advantages into discourse advantages remains insufficient, and the international community holds a dual perception of China’s technological advancements—recognition alongside concerns. The …

From Data To Intelligence: A Review Of Recent Technological And Theoretical Advances In Computational Communication Science, Mengxiao Zhu, Zongting Ge, Jiaojiao Ji

Bulletin of Chinese Academy of Sciences (Chinese Version)

Against the backdrop of a platform society and the rise of multimodal content, communication processes are increasingly mediated by algorithms, while digital traces continue to expand in scale and granularity. Building on the 2009 and 2020 “computational social science” initiatives as an intellectual lineage, open science and testable evidence have gradually become field-wide norms. Building on prior work, this study traces a “actors–content–platforms/algorithms–audience–effects” pathway to clarify what computational communication studies and what its central questions are, and to review how artificial intelligence is used across the 5W elements of the pathway. We further review international institutionalization driven by scholarly societies …

Combatting Desertification Scientifically: Where Feasible, Where Necessary, Bojie Fu, Yanxu Liu, Shuai Wang, Yijia Wang, Guipeng Cui, Yue Guo

Bulletin of Chinese Academy of Sciences (Chinese Version)

China has made remarkable achievements in combating desertification, achieving “zero net growth” in land degradation. With the goal of scientifically improving the relationship between humans and nature in drylands, the continuous exploration of new concepts, methods, and pathways for scientific desertification control will contribute to advancing the harmony between humans and nature in China’s drylands. Based on the definitions of desertification, ecological restoration baselines, and the contributions of nature to humans, we clarified the scientific implications of “controlling desertification where it is feasible and necessary”. We discussed the shift in China’s desertification prevention and control direction from “humans advancing while …

The International Decade Of Sciences For Sustainable Development: Global Progress And China’S Actions, Lin Wang, Shaofeng Hu, Fan Wang

Bulletin of Chinese Academy of Sciences (Chinese Version)

The International Decade of Sciences for Sustainable Development (IDSSD, 2024–2033) was officially launched by the United Nations in 2024, with the aim of strengthening and demonstrating the central role of science in achieving the Sustainable Development Goals (SDGs) and advancing the 2030 Agenda for Sustainable Development. This study systematically reviews the development of IDSSD, its governance structure, mechanisms for project solicitation and endorsement, as well as the thematic and regional distribution of endorsed initiatives. On this basis, it assesses China’s current participation and potential opportunities. During the first call for initiatives, IDSSD received 221 proposals from 52 countries, with 109 …

Theoretical Construction And Practical Transformation Of “New Science Popularization” In Process Of Chinese Modernization, Ting Wang, Haonan Du, Tian Zhu, Shihui Yang, Rongting Zhou

Bulletin of Chinese Academy of Sciences (Chinese Version)

Rooted in the historical context of China’s national strategy-driven science popularization (SP), this study analyzes the local practical integration of “science popularization” and “science and technology communication”. It proposes a theoretical framework for “new science popularization” suitable for a strong state-strong society collaborative governance environment, based on the fundamental hypotheses of “innovation-driven development”, “systemic coupling”, and “nodal creation”. The core argument introduces the “One Body, Two Wings; Three Layers, Three Stages” dynamic system model. This model elucidates how SP, under the unity of national strategy and human development, achieves a spiral evolution—from knowledge interconnection and literacy co-shaping to ecosystem co-creation—through …

Innovation-Oriented Science Popularization (Iosp): A New Paradigm For Frontier Science Communication And Innovation Capacity Building, Yong Ge, Yifei Li

Bulletin of Chinese Academy of Sciences (Chinese Version)

Under China’s strategy of becoming a science and technology powerhouse, traditional transmission-oriented science popularization inadequately addresses youth demands for frontier technology practice, constraining source innovation in talent cultivation. Informed by international approaches such as learning by doing and responsible research and innovation (RRI), together with domestic Chinese practices, this study formulates innovation-oriented science popularization (IOSP) as a new paradigm focusing on frontier technologies, deep experiential learning, and innovation capacity building. IOSP establishes a systematic implementation pathway through four integrated dimensions: layered content design, virtual-real fusion, industry-academia-research-user linkage, and multi-scenario coverage. Taking the Shanghai Youth Science Innovation Practice Workstation as a …

Construction Of Emerging Contaminants Risk Governance System, Cheng Li, Mingcheng Wang, Chunlei Li

Bulletin of Chinese Academy of Sciences (Chinese Version)

Emerging contaminants pose considerable risks to the ecological environment, human health, and social safety. The establishment of an emerging contaminants risk governance system constitutes a crucial component of the national ecological security strategy and the ecological civilization framework in the new era. When examined through the lens of the holistic view of national security and guided by the ecological civilization philosophy of the new era, China’s current efforts in managing emerging contaminants reveal several shortcomings—including a fragmented and incomplete risk management system, as well as preliminary stages in chemical environmental management policies and related technologies. Therefore, grounded in national conditions …

Conduction Paths And Policy Design Of New Quality Productivity Empowering Urban-Rural Integrated Development, Lulu Yang, Yi Wang

Bulletin of Chinese Academy of Sciences (Chinese Version)

The Fifth Plenary Session of the 20th Central Committee of the Communist Party of China emphasized that during the “15th Five-Year Plan” period, resolving the issues relating to agriculture, rural areas, and rural people must remain a top priority for the entire party, and efforts should be made to promote integrated urban-rural development. As an inevitable path to addressing the relative lag in agricultural and rural modernization, urban-rural integration has entered a new phase, transitioning from establishing institutional mechanisms to developing integrated factor allocation. This phase urgently requires new theoretical guidance and breakthroughs in dynamic models. This study constructs an …

Research And Reflections On Model Of China’S Ai Open-Source Innovation Ecosystem, Yuntao Long, Haibo Liu, Qigang Zhu, Xudong Ren, Yanjun Wu

Bulletin of Chinese Academy of Sciences (Chinese Version)

Open-source innovation, leveraging its strengths in collective collaboration and agile development, is increasingly becoming a core driver reshaping innovation paradigms and industrial ecosystems in the global artificial intelligence field. As a significant force in global technological development, China is actively promoting technology enterprises, research institutes, universities, and other diverse entities to deeply integrate into the construction of the global AI open-source innovation system through policy guidance, community building, and breakthroughs in large models. Based on the practical experience of building China’s AI open-source innovation ecosystem, this study systematically examines the current development status and challenges. By analyzing the operational models …

Transformation Of Open-Source Innovation Governance Of Large Models, Zhe Wang, Jinsong Cai

Bulletin of Chinese Academy of Sciences (Chinese Version)

Artificial general intelligence (AGI), represented by large-scale models, is a transformative driver of new-quality productive forces, making the effective construction and governance of open-source innovation commons increasingly critical. Yet traditional open-source models are under strain, and existing commons theories require further development. Model training costs rise exponentially with each iteration, while a sustainable profit cycle from innovation to industrial application has not been established, rendering long-term cost-bearing infeasible for individual organizations. The traditional community-enterprise collaboration model, once successful in generating ecosystem value, now faces escalating computing and data costs, uncertain commercial returns, and governance risks related to social and national …

Synergistic Strategies For Regional ‘Zero-Waste City’ Construction, Xiaolong Liu, Zongguo Wen, Yanyan Tang, Xiangwan Du

Bulletin of Chinese Academy of Sciences (Chinese Version)

“Recommendations of the Central Committee of the Communist Party of China for Formulating the 15th Five-Year Plan for National Economic and Social Development” emphasizes deepening cross-administrative cooperation, and improving mechanisms for inter-regional planning coordination, industrial collaboration, and benefit sharing to promote regional linked development. While China’s “zero-waste city” initiative has achieved remarkable results, its long-term sustainability necessitates a shift towards coordinated regional synergy. This requires establishing enduring mechanisms for collaborative solid waste governance that transcend governmental, hierarchical, and departmental boundaries. The ultimate goal is to optimize the allocation of waste treatment resources between neighboring and even non-adjacent regions, foster a …

Research Progress On Economic Impact Of Animal Diseases, Zhen Xu, Haizhao Zhang, Zizhong Shi, Hui Zhou, Xiangdong Hu

Bulletin of Chinese Academy of Sciences (Chinese Version)

Animal diseases not only pose significant challenges to the stable development of related industries such as livestock farming but also adversely affect the broader economic and social landscape. This paper presents the reviews on the current state of research both domestically and internationally, systematically presenting the advancements of the economic impacts of animal diseases. The findings reveal that, (1) the economic impacts of animal diseases can be categorized into direct and indirect effects; however, a unified analytical framework has yet to be established. The “Epidemiology-Economics” approach is the primary analytical method for assessing the economic impacts of animal diseases. (2) …

Research On Signal Perception System Of Key Technology Regulation In The United States, Kaile Wang, Hao Liu, Yunwei Chen

Bulletin of Chinese Academy of Sciences (Chinese Version)

The purpose of the study is to analyze the operation mechanism of the key technology control signal perception system, and reveal the deep logic and basic procedures of the United States’ external technical containment. Through literature review and information mining, this study analyzes the structural features of the U.S. key technology control signal perception system, such as “front-end technical perception and technology locking”, “mid-end technical evaluation and risk identification”, and “back-end technical control response and dynamic sanctions”. It further explores the participating subjects and role positioning of the United States in key technology control signal perception, the sources and mechanisms …

Implementing Staff Education To Improve Depression Detection In Primary Care Using Patient Health Questionnaire (Phq-9), Ukamaka Okeke

Walden Dissertations and Doctoral Studies

This staff education project focuses on improving depression detection in a primary care settings using Patient Health Questionnaire (PHQ-9) screening tool. Depression is a leading cause of disability worldwide, requiring reliable and adaptable screening tools. The diagnosis of depression is one of the most common mental health disorders in primary care but is poorly identified and frequently missed. The lack of consistent screening for depression among patients often results in delayed identification of symptoms, which postpones early treatment, increasing the risk of complications associated with untreated depression. The practice site identified that depression screening was frequently missed during patient intake, …

Welcome To The Trump Administration’S Board Of Immigration Appeals. The Immigrant Always Loses., Jason A. Cade

Scholarly Works

The first 100 opinions in Volume 29 of the Board of Immigration Appeals’ precedential decisions—issued at more than three times the historical pace—constitute a project. The Trump Administration has used the Attorney General’s self-referral power and a reconstituted, ideologically aligned Board to engineer a body of precedents that reliably produces one result: removal. This Essay organizes these decisions, cataloged in a full Appendix, into five main categories: (1) narrowing relief for noncitizens alleging persecution; (2) expanding mandatory detention while narrowing discretionary release; (3) maximizing the immigration consequences of criminal history and related grounds while foreclosing the relief mechanisms Congress created …

Curricular Changes Proposed For 2025-2027 Morris Catalog, Curriculum Committee

Curriculum Committee Reports

Includes documentation on the discontinuation of Sociology, Geology, German Studies, and Latin American Area Studies (LAAS).

Beyond Technical Performance: Preliminary Findings On Algorithm Aversion In Digital Library Environments, Hengyi Fu, Fenfang Cao

Faculty Research, Scholarly, and Creative Activity

Introduction. This study examines algorithm aversion in digital library contexts, where users increasingly encounter algorithm-enabled services. Prior research in healthcare and finance shows that users often resist algorithmic systems even when they outperform human alternatives, yet little is known about how this phenomenon manifests in the digital libraries context. Method. As part of an ongoing project, we conducted semi-structured interviews with 18 users from two Chinese universities. Participants were selected through theoretical sampling. Interviews were analysed using constructivist grounded theory. Analysis. Open and axial coding of the first 18 interviews produced 42 initial concepts organised into 16 categories under five …

Science Challenges And Solutions To Support Implementation Of The Biodiversity Beyond National Jurisdiction Agreement, Claire L. Szostek, Angus Atkinson, Victor Martinez-Vicente, Ana M. Queirós, Peter I. Miller, Kerry L. Howell, Rebecca C. Millington, Susan Kay, Matthew Faith, Karen Tait, Elizabeth Talbot, Andrew Rees, Chris Lyal, Jeff Ardron, Matthew Frost

School of Biological and Marine Sciences

The Biodiversity Beyond National Jurisdiction (BBNJ) Agreement provides a new opportunity to consolidate and achieve global marine environmental goals. Here we focus on how science and technology will support its implementation. We provide an overview of existing scientific knowledge and methods that are scalable to Areas Beyond National Jurisdiction (ABNJ). Reviewing data gaps, challenges and opportunities, we outline solutions and a roadmap focused on enhancing resources and capacity.

Survival Politics On A Working Waterfront: Rules Change Faster Than Prices In The South Texas Shrimp Fishery, Owen Temby, Anthony R. Lima

School of Earth, Environmental, & Marine Sciences Faculty Publications

In 2024–2025, the U.S. and Texas governments raced to save Gulf shrimp. Texas passed a truth-in labeling law for food service in restaurants. Federal agencies added antidumping and countervailing duty orders and new tariffs. This case follows Brownsville and Port Isabel, where dock prices slid while boats and crews aged. We frame the response as survival politics: urgent and improvised moves to keep a livelihood going even when imports set the price. Using legislative hearings, agency notices, local reporting, and port records, we show that rules reset faster than prices. Inventories, contracts, and supplier substitution delay any lift at the …