Digital Commons Network^™

Mda5-Mavs And Interferon-Lambda Signaling In The Intestinal Epithelium Limit Murine Astrovirus Infection, Heyde Makimaa, Harshad Ingle, Leran Wang, Somya Aggarwal, Hongju Deng, Elizabeth A Kennedy, Lynne Foster, Yuhao Li, Megan T Baldridge

2020-Current year OA Pubs

Human astroviruses (HAstVs) are a global cause of pediatric gastroenteritis and can cause disseminated infection in immunocompromised hosts. Murine astrovirus (muAstV) causes acute asymptomatic infections in immunocompetent mice and chronic infection in immunodeficient models and has provided important insights into AstV pathogenesis in vivo. MuAstV can protect immunodeficient mice from other enteric viruses via robust induction of antiviral cytokine interferon-lambda (IFN-λ), with recent findings implicating goblet cells and enterocytes as both cell types infected by muAstV as well as potential sources of IFN-λ in vivo. However, the viral sensing pathways that regulate induction of IFN-λ, as well as the specific …

Ten Tips On How To Prevent And Manage Post-Transplant Lymphoproliferative Disease In Kidney Transplant Recipients, Rose Mary Attieh, Armin Ghobadi, Naoka Murakami

2020-Current year OA Pubs

Post-transplant lymphoproliferative disease (PTLD) remains a challenging and high-impact complication of kidney transplantation, requiring thoughtful prevention, timely recognition, and multidisciplinary management. Key strategies include careful selection of immunosuppressive regimens, particularly avoiding belatacept in Epstein-Barr virus (EBV)-seronegative recipients and exercising caution with lymphodepleting induction in EBV-mismatched pairs, along with targeted EBV surveillance in high-risk patients. Once PTLD is suspected or confirmed, accurate staging and a stepwise treatment approach beginning with reduction of immunosuppression and escalating to rituximab, chemotherapy, or advanced cellular therapies are essential, with EBV-CTLs and chimeric antigen receptor T-cell therapy offering promising options in refractory disease. Close monitoring for …

Differential Regulation Of Cyclic Adenosine Monophosphate By Phosphodiesterase 3a Discriminates Thrombin-Induced Protease Activated Receptor 1- And 4-Dependent Platelet Activation, Izabella Andrianova, Abigail Ajanel, Jesse W Rowley, Darian C Murray, Yasuhiro Kosaka, Frederik Denorme, Paul F Bray, Robert A Campbell

2020-Current year OA Pubs

BACKGROUND: Human platelets express 2 thrombin-activated G protein-coupled receptors (GPCRs), protease activated receptor (PAR)1 and PAR4. Previous studies have demonstrated PAR1 activation to be fast on-fast off while PAR4 activation was slower but more sustained. However, how PARs regulate second messengers such as cyclic adenosine monophosphate (cAMP), a negative regulator of platelet activation, remain unknown.

OBJECTIVES: This study investigated how PAR1 and PAR4 activation by thrombin regulates cAMP levels and platelet activation.

METHODS: PAR1 and PAR4 on washed human platelets were inhibited with vorapaxar or BMS-986120, respectively, in the presence or absence of prostaglandin (PG)I

RESULTS: In the presence of …

Lyplal1 Rare Loss-Of-Function Variants In Humans And Deletion In Human Hepatoma Cells Protect Against Masld, Rawdat Hussain, Chinmay Raut, Ponnandy Prabhu, Akram Irshaid, Yash Hegde, Yue Chen, Asmita Pant, Antonino Oliveri, Xiaochao Wei, Lishi Yin, Tiffany L Russell, Brian Halligan, Clay F Semenkovich, Elizabeth K Speliotes

2020-Current year OA Pubs

Genetic variants near LYPLAL1 are associated with Metabolic dysfunction-Associated Steatotic Liver Disease (MASLD) in humans, but their impact on LYPLAL1 function is unknown. We identified LYPLAL1 loss-of-function variants from UK BioBank (UKBB) whole-exome sequencing data that had AlphaMissense or GPN-MSA scores in the top 20% of LYPLAL1 variants for being disruptive. We aggregated these variants and carried out burden analysis for effects on MRI Proton Density-Fat Fraction (MRI-PDFF) and ICD-based MASLD in UKBB. Rare loss-of-function LYPLAL1 variants were associated with reduced MRI-PDFF and ICD diagnosed MASLD across sexes. We used CRISPR to knockout and overexpress LYPLAL1 in human hepatoma cells …

Promoting Positive Youth Development With Adolescent Boys In Uk Schools: A Theory-Driven Evaluation Of The “Becoming A Man” Programme, Finlay Green, Cristina Preece, Kate Allen, Sean Manzi, Julia Mannes, Lynne Callaghan, Vashti Berry, Ediane Santana De Lima, Amy Woodburn, Tim Hobbs, Julie Harris, Nick Axford

Peninsula Medical School

Youth violence, including gender-based violence, is a major public health issue in the UK, yet evidence on effective interventions in the UK remains limited. Becoming a Man (BAM) is a two-year school-based positive youth development programme for adolescent boys, developed in Chicago, US, where two RCTs found reduced violent crime arrests and improved academic engagement. This study evaluated BAM’s potential in the UK using a theory-driven design (no comparison group). 97 boys aged 12–14 years (66% Black/Black British) in three London schools enrolled in BAM. Data sources included: implementation records (recruitment, attendance, adherence, quality, youth socio-demographics); school data (attendance, exclusions, …

Partisan Differences In Risk-Taking In A Simulated Pandemic, Jan K. Woike, Sebastian Hafenbrädl, Patricia Kanngiesser, Ralph Hertwig

School of Psychology

Responses to COVID-19 in the United States were split along partisan political lines throughout the pandemic. People on the political left tended to take the medical threat more seriously and were more likely to adopt preventive health behaviors than those on the political right, resulting in clear differences in state-level policies and health consequences. Here, we examine the origins of these differences, investigating whether they are based on interindividual differences or in party dynamics. Two groups of participants (N=819), who had voted either for Donald Trump or Hillary Clinton in 2016, played the Transmission Game. Players made repeated decisions in …

A Dataset Of Precipitate-Containing Multi-Principal Element Alloys, Anshu Raj, Xin Wang, Matthew Luebbe, Haiming Wen, Kun Lu, Shuozhi Xu

Materials Science and Engineering Faculty Research & Creative Works

We report a curated dataset that brings together composition, processing conditions, microstructural details, and mechanical properties for 396 combinations of alloy composition and processing condition drawn from 100 peer-reviewed research articles on precipitate-containing multi-principal element alloys (MPEAs). The dataset was created by first utilizing a generative large language model for information extraction, followed by expert review to ensure accurate recovery of materials data. Compositional information was taken directly from tables and text, while processing routes — including homogenization, rolling, recrystallization, and aging — were converted into uniform temperature and time metrics. Microstructural descriptors, including precipitate phases and sizes, were consolidated …

Ac Magnetic Measurements With A Self-Oscillating Lc Circuit And Its Application To University Education, Harshit Agarwal, Oleksandra Uralska, Jasmin Billingsley, Maxim Yamilov, Hyunsoo Kim

Physics Faculty Research & Creative Works

Editor's Note: This paper is a welcome tutorial on a technique for AC magnetometry, allowing the measurement of a sample's magnetic susceptibility with considerable sensitivity. The authors present a low-cost setup based on an LC self-oscillator circuit, which has an operating frequency that is rather sensitive to the susceptibility of a sample introduced within its inductor. After characterizing the performance of the circuit, data taken on a high-temperature superconducting sample are presented, demonstrating how the samples superconducting transition can be detected by this noncontact magnetic method, independent of the usual resistivity-based detection. This project will be of interest to instructors …

Correlated Many-Body Quantum Dynamics Of The Peregrine Soliton, D. Diplaris, G. A. Bougas, P. G. Kevrekidis, C. L. Hung, P. Schmelcher, S. I. Mistakidis

Physics Faculty Research & Creative Works

We explore the correlated dynamics underlying the formation of the quantum Peregrine soliton, a prototypical rogue-wave excitation, utilizing interaction quenches from repulsive to attractive couplings in an ultracold bosonic gas confined in a one-dimensional box trap. The latter emulates the so-called semiclassical initial conditions and the associated gradient catastrophe scenario facilitating the emergence of a high-density, doubly localized waveform. The ensuing multiorbital variant of the Peregrine soliton features notable deviations from its mean-field sibling, including a reduced peak amplitude, wider core, absence of the side density dips, and earlier formation times. Moreover, Peregrine soliton generation yields coherence losses, while experiencing …

Promoting Community And Social Participation In Chronic Stroke: A Pilot Study Of The Engage Intervention, Elizabeth Skidmore, Carolyn Baum, Jessica Kersey, Emily Kringle, Kelsey Voltz-Poremba, Sular Gordon, Tina Harris, Heidi Fischer, Maureen Gecht, Michelle Furman, Joy Hammel

2020-Current year OA Pubs

BACKGROUND: Survivors of stroke report low levels of community and social participation, even years after stroke. ENGAGE is a community-based intervention that merges social learning, guided problem solving, and supervised practice to collaboratively identify, generate, and apply solutions to challenges with community and social participation after stroke.

OBJECTIVE: We examined the feasibility, acceptability, and safety of ENGAGE and characterized within group changes in community and social participation outcomes.

METHODS: Community-dwelling survivors of stroke, occupational therapy providers, and occupational therapy scientists partnered to co-design the essential and structural elements of ENGAGE, as well as to evaluate ENGAGE using a multi-site single-arm …

Discovery And Genome Annotation Of Tuti And Charminar: Two Newly Discovered Gordonia Rubripertincta Bacteriophages, Tracey Alexis, Melissa Bassily, Jayden Courtney, Tamanna Dipen Shah, Javier Estepa, Malak Gadelkarim, Wayne Jean-Baptiste, Elias Leyes, Anushka Malay, Mackenzie Nezat, Mahisvi Vemulapalli

Undergraduate Student Symposium

As the most abundant organisms, bacteria are both beneficial and harmful, highlighting the significance of regulating their growth. Bacteriophages (phages) are ubiquitous viruses that require a host bacterial organism for replication, making them an essential component of the microbial ecosystem and used as tools for killing bacteria. Since their discovery in 1915, phages have been used in real-world applications including alternatives to antibiotics, diagnostic agents, pest control in agriculture, wastewater treatment, and bioremediation. Since bacteriophages remain mostly undiscovered, continued isolation and genetic characterization of novel phages are essential for advancing scientific knowledge and potential applications. Through Nova Southeastern University's SEA-PHAGES …

Addressing Burnout In Medical Education: A Meta-Analysis Of Florida Medical School, Riddhi Banjeree

Undergraduate Student Symposium

Burnout and mental health issues in medical students in the United States have become increasingly prominent -- posing challenges for student well-being, patient care, and the future of the physician workforce. Burnout is characterized by emotional exhaustion, depersonalization, and a loss of personal accomplishment. These traits can develop early in med school, perpetuate throughout their training years, and are reinforced by demanding academic workloads, competitive exams, and emotionally taxing clinical experiences. The purpose of this project is to examine mental health, counseling, and wellness resources offered across eight medical schools in Florida - U Miami, UCF, UF, USF, FAU, FIU, …

Gathering College Students' Interests In Bone Health By Promoting Vitamin K2 Consumption, Nida Haider

Undergraduate Student Symposium

The human skeleton requires constant sources of nutrients (calcium, vitamin D3, vitamin K) for bone remodeling, maintaining bone mass, and bone density. While there is existing evidence regarding the benefits of calcium and vitamin D3 on bone health, there have been recent studies of the effects of vitamin K derivatives (vitamins K1 and K2) on bone maintenance. The growing popularity of the new over-the-counter supplement named "Vitamin D3 + K2" has initiated our interest in a deeper understanding of the mechanisms of the vitamin K derivatives' roles in bone health regulation. Vitamin K is a fat-soluble vitamin that naturally exists …

Enhancing Co2 Adsorption And Co2/N2 Separation Performance By Incorporating Calcium In Mil-53 (Al), Hussein Rasool Abid, Hussein Znad, Nabil Majd Alawi, Farhan Lafta Rashid, Anmar Dulaimi, Amer Alanazi, Alireza Keshavarz, Stefan Iglauer, Shaobin Wang

Research outputs 2022 to 2026

Global warming is primarily driven by the rapid accumulation of carbon dioxide (CO₂) in the atmosphere. Metal–organic frameworks (MOFs) have emerged as promising materials for mitigating CO₂ emissions due to their tunable porosity, large surface area, and structural flexibility. Among them, MIL-53(Al) has attracted widespread interest owing to its excellent thermal and chemical stability. Recent studies show that modifying MOFs with secondary metals can significantly enhance their CO₂ adsorption performance. In this work, a one-pot synthesis method was employed to incorporate calcium (Ca), functioning as a Lewis basic metal, into the MIL-53(Al) framework to produce a series of bimetallic materials: …

An Integrated Tracking Technique For Underwater Navigation Using Acoustic And Imu Measurements, Mainul Islam Chowdhury, Quoc Viet Phung, Iftekhar Ahmed, Daryoush Habibi

Research outputs 2022 to 2026

Accurate navigation is essential for underwater vehicles like AUVs, which often operate in deep or remote areas. However, complex ocean dynamics, cumulative inertial-measurement unit (IMU) drift, and diverse noise sources often result in erratic and unreliable position estimates. To overcome these challenges, we proposed a method that combines underwater acoustic signals with onboard motion sensor data to improve the underwater position tracking system. The proposed system uses a long baseline (LBL) acoustic array of surface buoys to capture the Time-difference-of-Arrival (TDoA) of a multi-pulse beacon. We extract arrival times using a superimposed-envelope-spectrum (SES) detector, which exploits the beacon’s periodic structure …

Combined Effect Of Sarcopenia And Impaired Respiratory Function On All-Cause Death: A Nationwide Cohort Study, Chutao Wu, Dan Wu, Mu Li, Senrong Lu, Yukai Wang, Yulong Lan

Research outputs 2022 to 2026

Background: Respiratory fitness and sarcopenia status have been reported to be cross-sectionally linked with each other and increase mortality risk. However, little is currently known regarding the connection between impaired respiratory function and sarcopenia and their joint effect on future death risk. Methods: This study included 12 027 participants (50.8% were women; mean [SD] age, 58.9 [9.3] years) from a nationwide, prospective cohort in China (China Health and Retirement Longitudinal Study). Respiratory function was assessed by peak expiratory flow (PEF). Sarcopenia status was assessed according to the Asian Working Group for Sarcopenia 2019 (AWGS 2019) criteria. Time-to-event survival analyses and …

Engineering Zinc Anodes Through Advanced Manufacturing Strategies For Next-Generation Zinc–Air Batteries, Yasir Arafat, Kareem Bakhsh, Muhammad Rizwan Azhar

Research outputs 2022 to 2026

Rechargeable zinc–air batteries (ZABs) are promising next-generation energy storage systems due to their high energy density, intrinsic safety, and low cost. Nevertheless, commercial deployment of Zn anodes is hampered by persistent challenges like dendrite formation, deformation, passivation, corrosion, and the hydrogen evolution reaction. This review systematically highlights the critical relationship between anode morphology and electrochemical performance and discusses recent advances in advanced manufacturing strategies for Zn anodes. Additive manufacturing approaches, such as 3D printing, enable the fabrication of porous and tunable Zn electrodes with enhanced surface area and uniform ion flux distribution. Furthermore, advanced materials processing techniques like alloying, coatings, …

The Association Of Apolipoprotein E Ε4 With Symptomatic Intracerebral Hemorrhage, Mri Markers And Cognition In Dutch-Type Hereditary Cerebral Amyloid Angiopathy, Maaike C. Van Der Plas, Rosemarie Van Dort, Ingeborg Rasing, Yongxi Long, Erik W. Van Zwet, Matthias J.P. Van Osch, Hamid R. Sohrabi, Kevin Taddei, Samantha L. Gardener, Ralph N. Martins, Steven M. Greenberg, Gisela M. Terwindt, Marianne A.A. Van Walderveen, Marieke J.H. Wermer

Research outputs 2022 to 2026

Background: Apolipoprotein E (APOE) genotype influences the presence, course and severity of sporadic cerebral amyloid angiopathy (sCAA). We investigated the effect of the APOE ε4-allele on clinical and neuroradiological outcomes in mutation-carriers with Dutch-type hereditary (D-)CAA. Methods: Participants with D-CAA from a prospective cohort study, with data collected on history of symptomatic intracerebral hemorrhages (sICH) and vascular risk factors, underwent 3 Tesla magnetic resonance imaging (MRI) scans to assess macrobleeds, cerebral microbleeds (CMBs), cortical superficial siderosis (cSS), enlarged perivascular spaces (EPVS), white matter hyperintensity (WMH) volume and WMH multispot lesions. Global cognition was measured using Montreal Cognitive Assessment (MoCA) and …

A Flexible Wearable Glucose Sensor For Noninvasive Diabetes Screening: Functional Equivalence And Model Interpretability, Wenhan Xie, Wang, Hao Liu, Shuo Chen, Peng Wang, Yumei Han, Xianxiang Chen, Zhen Fang, Zhan Zhao, Guohong Zhang, Xiuhua Guo

Research outputs 2022 to 2026

Real-world evidence for wearable noninvasive glucose monitoring (NIGM) remains limited. To evaluate the functional equivalence of a wearable NIGM device and explore its utility for T2DM and prediabetes screening. In this multicenter study, 12-h daytime glucose profiles obtained by a flexible reverse iontophoresis-based electrochemical sensor were compared with capillary glucose using functional equivalence. Subgroup analyses were conducted. Screening models of T2DM and prediabetes were developed using elastic net and Logistic regression. A total of 135 participants (mean age 35.3 years; 60.0% female) were included, and no serious device-related adverse events were reported. Compared to the capillary measurements, functional equivalence was …

Abca4 Versus Prph2-Associated Retinopathy: Clinical And Electrophysiological Findings, Rachael C. Heath Jeffery, A. Thompson, Johnny Lo, Andrea L. Vincent, Minal Patil, Lorenzo Bianco, Maurizio Battaglia Parodi, Lucia Ziccardi, Carmen Dell’Aquila, Lucilla Barbano, Wei Chao Tang, Choi Mun Chan, Camiel J.F. Boon, Jonathan Hensman, Ta Ching Chen, Chien Yu Lin, Pei Lung Chen, Ajoy Vincent, Anupreet Tumber, Elise Heon, John R. Grigg, Robyn V. Jamieson, Elisa E. Cornish, Benjamin N. Nash, Jeremy Chou, Tina M. Lamey

Research outputs 2022 to 2026

Purpose. The purpose of this study was to characterize the clinical features, electrophysiology, and variant spectrum in ABCA4- and PRPH2-retinopathies and to identify novel electrodiagnostic biomarkers to differentiate between these two genotypes. Methods. We conducted an international multicenter case-control study of patients with a clinical and genetic diagnosis of ABCA4- or PRPH2-retinopathy. Age at symptom onset, best-corrected visual acuity (BCVA), electroretinography (ERG) components, and fundus autofluorescence (FAF) imaging were compared. Subgroup exploratory analysis was performed on those patients with a phenotype similar to central areolar choroidal dystrophy (“CACD-like”), those with flecks distributed throughout the posterior pole (“fleck-like”) and a healthy …

Collaboration Between People Admitted To Acute Mental Health Units, Their Family Members And Nurses In The Detection Of Mental State Changes And Recovery: A Qualitative Systematic Review, Karen Foster, Coventry, Yvonne Middlewick, Lindsay Smith, Beverley Ewens

Research outputs 2022 to 2026

Mental health nurses can engage with people with mental health challenges and their families due to their presence on acute mental health units. This presence helps to facilitate recovery-focused care within a physically and emotionally safe environment. Mental health care should be person-centred, individualised, and include wherever possible family and other people in the person's support network. The objective of this systematic review was to explore the existing qualitative literature that describes experiences of collaboration between people with lived experience of mental health challenges, their family members, and nurses in relation to changes in mental state during an admission to …

Disuse-Induced Muscle Atrophy And Muscle Weakness From Hospitalization To Spaceflight: Exercise Succeeds In Prevention And Treatment—A Meta-Analysis, Camila S. Padilha, Figueiredo, Rafael Deminice, S. Ribeiro, Robert U. Newton, Nicolas H. Hart, José Cesar Rosa-Neto, Marília Seelaender, Fábio Santos Lira

Research outputs 2022 to 2026

Background: Exercise has been proposed as both a preventive and therapeutic countermeasure; however, its effectiveness across different disuse conditions and timings of implementation remains uncertain. Methods: This systematic review and meta-analysis (PROSPERO: CRD42021256599) searched ClinicalTrials.gov, Cochrane Central, PubMed, SPORTDiscus, Web of Science, Scopus, CINAHL and SciELO from inception to May 2021, with an update in March 2025. Randomized and nonrandomized controlled trials examining exercise interventions during or after muscle disuse were included according to the PICOS framework. Random-effects meta-analysis evaluated effects on muscle strength, power and mass across hospitalization, bed rest and spaceflight conditions. Effect sizes (ES) are reported as …

Facilitating Food Security Systems Change In Regional Australia Through A Strengths-Based, Co-Design Process, Isabelle Chiera, Doe, Melissa Stoneham, Amanda Devine, Stephanie L. Godrich

Research outputs 2022 to 2026

Food security is a multifaceted, ‘wicked’ issue that refers to the sufficient physical, social, and economic access to food at all times. Given its complexity, food security action requires a systems-based, collaborative, and adaptive approach. This paper outlines the application of a strengths-based, co-design process to support food security systems change among government and community-led initiatives operating in rural, regional, and remote areas of Western Australia. Baseline, semistructured interviews were conducted with leaders of food initiatives to understand whether and how the initiatives were contributing to food security systems change and identify the ‘windows of opportunity’ where initiatives could be …

Federated Retrieval-Augmented Generation For Cybersecurity In Resource-Constrained Iot And Edge Environments: A Deployment-Oriented Scoping Review, Hangyu He, Yuan, Kai Wu, Wei Ni

Research outputs 2022 to 2026

Cybersecurity operations in IoT and edge environments require fast, evidence-grounded decisions under strict resource and trust constraints. While large language models can support triage and incident analysis, their parametric knowledge may be outdated and prone to hallucination. Retrieval-augmented generation (RAG) improves grounding by conditioning responses on retrieved evidence, but also introduces new risks such as knowledge-base poisoning, indirect prompt injection, and embedding leakage. Federated learning enables collaborative adaptation without centralizing sensitive data, motivating federated RAG (FedRAG) architectures for distributed cybersecurity deployments. This study presents a deployment-oriented scoping review of FedRAG for cybersecurity. The review follows PRISMA-ScR reporting guidance and synthesizes …

Impact Of Cannabis And Cannabis Legalization On Us Atrial Septal Defect Rates, Albert Stuart Reece, Hulse

Research outputs 2022 to 2026

Atrial septal defect (ASD) affects 1:11.3 children in some US states; however, the antecedents of these trends are yet to be identified. A total of 1882 ASD rates (ASDRs) for 2003–2020 were sourced from the National Birth Defects Prevention Network reports. A total of 406,893 ASDs are reported. Substance (cigarettes, binge alcohol, cannabis, cannabinoids, analgesics, cocaine) exposure data were taken from the National Survey of Drug Use and Health. Income and ethnicity data were derived from the US Census. Adjustment was performed by mixed effects, survey and generalized additive regression. Causal analysis was by inverse probability weighting and E-values. Data …

Influence Of Simulator Physical Fidelity And Immersion On Decision-Making Skill, Presence, And Cognitive Load, Zachariah G. Hoyne, Morris-Binelli, Sean Müller, Benjamin Piggott, Paola Chivers, Evan Dekker

Research outputs 2022 to 2026

In a variety of domains such as law enforcement and sport, virtual reality is being explored to simulate field-based decision-making contexts. 360-degree video virtual reality (360VR) is innovative as it can immerse the user in a simulated environment, present egocentric, stereoscopic vision and allows for head movements to perceive visual information. However, it is unknown whether physical, rather than psychological fidelity, is crucial for performance, and its impact upon cognitive load, relative to immersion. This study investigated simulator fidelity, presence, and cognitive load across immersion (two-dimensional video and 360VR) in an exemplar sport-specific decision-making task. Thirty skilled Australian Rules Football …

Longitudinal Assessment Of Health-Related Quality Of Life In Adults With Ckd, Owen Ng, Teixeira-Pinto, Anh Kieu, Anita Van Zwieten, Anoushka Krishnan, Kirsten Howard, Wai H. Lim, Jeremy R. Chapman, Simon D. Roger, Michael J. Bourke, Shaundeep Sen, Steven J. Chadban, Carol A. Pollock, Allison Jaure, Jonathan C. Craig, Jean Yang, Germaine Wong

Research outputs 2022 to 2026

Key Points: Dialysis linked with poorer quality of life compared with transplant patients and patients with CKD. Quality of life trends were similar in both domain-specific and overall quality-of-life measures. Background: There are sparse data about the change in health-related quality of life (HRQoL) with the temporal progression of CKD. In this study, we assessed the association between change in CKD stages, overall and domain-specific quality of life and determined the factors that were associated with this change. Methods: Data were sourced from a multicenter study that included 1290 adult patients aged 18 years and older across six centers in …

Rapid Isometric Hamstring Strength Scores From Professional Soccer Players At Pre-Season: Positional Differences And Relationship To Peak Force, Nicholas Joel Ripley, Ross, Jack Fahey, Christopher Bramah, Paul Jones, Paul Comfort

Research outputs 2022 to 2026

The assessment of rapid force within a single joint assessment is becoming common practice within elite sport environments. Recent observations have highlighted that rapid force maybe more sensitive to fatigue than peak force within the hamstrings. Yet limited information exists on rapid force production in elite male soccer players. Eighty-nine senior professional men’s soccer players (age; 24.2±5.1 years, height; 1.83±0.05 m, mass; 78.95±7.53 kg) participated within the present study they performed two isometric assessments at joint angles of 30° and 90° of hip flexion and knee. They performed three trials with mean and standard deviation determined differences between soccer positions …

Space-Time Analysis Of Burgeoning Us Atrial Septal Defect Rates Driven By Cannabis, Albert Stuart Reece, Kenneth Hulse

Research outputs 2022 to 2026

Atrial septal defect (ASD) has become increasingly common in the USA and now affects 1 in 11.3 children in some places, but space–time analysis has not been applied to this emerging trend. ASD rate (ASDR) data were obtained from the National Birth Defects Prevention Network 2003–2020. Substance (cigarettes, alcohol, cannabis, analgesics, cocaine) use data were obtained from the National Survey of Drug Use and Health. Income data were obtained from the US Census. Analysis was limited to the Non-Hispanic White population by technical factors. Time-sequential univariate and bivariate maps were prepared for both covariates and outcomes and their combinations. Spatial …

The Age Of Activewear: Understanding Women’S Casualized Athletic Apparel Habits Through Associations With Psychosocial And Body Image Factors, Ross C. Hollett, R. Sharman, Domenic D’Adamo

Research outputs 2022 to 2026

Activewear has become a common component of women’s everyday clothing, yet emerging evidence suggests that exposure to activewear imagery may adversely affect body image. This study aimed to describe women’s activewear engagement across contexts and to investigate how different markers of engagement correspond with positive outcomes such as fitness behavior, body appreciation, and self-esteem, as well as negative outcomes including media pressure, idealized appearance aspirations, and self-objectification. We collected survey data from student (N = 455) and community (N = 374) samples to assess activewear-related behaviors, including online browsing, social media following, purchasing, and wearing, as well as measures of …