Digital Commons Network^™

A Rare Case Of Pancreatic Actinomyces, Shilpa Jain, Robert Sealock

Faculty, Staff and Students Publications

Actinomyces israelii is a filamentous, gram-positive anaerobic bacterium commonly found in the upper gastrointestinal tract, colon, and female genital tract. Rarely, actinomycosis can infect the pancreas most commonly after pancreatic instrumentation, often mimicking malignancy. We describe a case of a 26-year-old woman who presented with epigastric abdominal pain and nausea without prior pancreatic instrumentation. Abdominal imaging demonstrated a mass in the pancreatic head with fine-needle biopsy revealing Actinomyces. The patient was successfully treated with long-term antibiotic therapy resulting in resolution of the mass. Our case emphasizes the importance of considering nonmalignant etiologies in the differential diagnosis of pancreatic masses.

Implications Of The Paradigm Shift In Management Of Helicobacter Pylori Infections

Faculty, Staff and Students Publications

The recent availability of susceptibility testing for Helicobacter pylori infections in the United Sates has resulted in paradigm shifts in the diagnosis, therapy, and follow-up of H. pylori infections. Here, we reviewed the English literature concerning changes in H. pylori diagnosis and therapy with an emphasis on the last 3 years. We focus on the new methods that offer rapid and convenient susceptibility testing using either invasive (endoscopic) or noninvasive (stool) methods of obtaining test material. We also discuss the implications of this availability on therapy and follow-up after therapy. The approach to therapy was categorized into four groups: (1) …

Transcriptomic Analyses Of Ovarian Clear-Cell Carcinoma With Concurrent Endometriosis, Noah B Davis, Maria C Martinez, Chi Zhang, Kaman So, Aaron Buechlein, Douglas B Rusch, Chad J Creighton, Shannon M Hawkins

Faculty, Staff and Students Publications

INTRODUCTION: Endometriosis, a benign inflammatory disease whereby endometrial-like tissue grows outside the uterus, is a risk factor for endometriosis-associated ovarian cancers. In particular, ovarian endometriomas, cystic lesions of deeply invasive endometriosis, are considered the precursor lesion for ovarian clear-cell carcinoma (OCCC).

METHODS: To explore this transcriptomic landscape, OCCC from women with pathology-proven concurrent endometriosis (n = 4) were compared to benign endometriomas (n = 4) by bulk RNA and small-RNA sequencing.

RESULTS: Analysis of protein-coding genes identified 2449 upregulated and 3131 downregulated protein-coding genes (DESeq2, P< 0.05, log2 fold-change > |1|) in OCCC with concurrent endometriosis compared to endometriomas. Gene set enrichment …

Editorial: Biological Drivers Of Vector-Pathogen Interactions – Vol Ii

Faculty, Staff and Students Publications

No abstract provided.

Editorial: Forebrain Control Of Breathing And Sudden Death In Epilepsy, Steven A Crone, Brian J Dlouhy, Christina Gross, Russell S Ray

Faculty, Staff and Students Publications

No abstract provided.

Wastewater Pandemic Preparedness: Toward An End-To-End Pathogen Monitoring Program, Juwan Cormier, Kristi Louise Hoffman, Catherine Troisi, Blake Hanson, Joseph Petrosino, John Balliew, Pedro A Piedra, Janelle Rios, Jennifer Deegan, Cici Bauer, Fuqing Wu, Kristina D Mena, Eric Boerwinkle, Anthony W Maresso

Faculty, Staff and Student Publications

Molecular analysis of public wastewater has great potential as a harbinger for community health and health threats. Long-used to monitor the presence of enteric viruses, in particular polio, recent successes of wastewater as a reliable lead indicator for trends in SARS-CoV-2 levels and hospital admissions has generated optimism and emerging evidence that similar science can be applied to other pathogens of pandemic potential (PPPs), especially respiratory viruses and their variants of concern (VOC). However, there are substantial challenges associated with implementation of this ideal, namely that multiple and distinct fields of inquiry must be bridged and coordinated. These include engineering, …

A Music Teacher’S Use Of Informances With Primary Level Classes And Study Of Family Attitudes For Music Education: An Action Research Study, Joseph Cooke Emerson

Graduate Theses/Dissertations

Concerts are often the summative project for the elementary music room. However, the emphasis on concerts creates challenges for music instruction. The preparation for a traditional concert often takes away from instructional time, which is already limited for music instruction. Second, the use of concerts conceals many aspects of the instructional process from students’ families. This results in a limited view and understanding of their child’s formal musical education. By designing opportunities for parents and other stakeholders to see students beyond a traditional concert, I thought that I could help to deepen families understanding of music education in my elementary …

Pulsed Laser Deposition Approach To Metal Organic Thin Film Growth With Thin Film Developments And Applications In Electrochemical Sensing Of Heavy Metal, Jacob A. Berry

Graduate Theses/Dissertations

In recent years metal organic frameworks (MOFs), have drawn a lot of attention for their vast and tunable properties. This work is an approach to solve device application issues at the interface of the crystals by introducing a thin-film approach to the self-assembly of the metal organic. The growth using Pulsed Laser Deposition to solve this issue is a novel approach to device and film development. Films have been characterized using Raman spectroscopy, Fourier-Transform infrared spectroscopy (FTIR), X-ray photoelectron spectroscopy (XPS), X-ray Diffraction, Ellipsometry, laser scanning confocal microscope (LSCM), electrical measurement. Studying the properties of the grown film to compare …

Continuity And Contrast In The Strategic Theories Of Four Classic Strategic Thinkers: Sun Tzu, Thucydides, Machiavelli, And Clausewitz, Morteza Safari

Graduate Theses/Dissertations

The purpose of this research paper is to examine the thinking of four classic strategic theorists, namely Sun Tzu, Thucydides, Niccolò Machiavelli, and Carl von Clausewitz, and explore continuity and contrast in their strategic theories. In doing so, this author has structured the paper based on the fundamental architecture of strategy, that is, ends, ways and means. Since the paper specifically addresses military strategy, it first investigates what the ideas of the four theorists are on war as the military means. Then, the paper will explore the theorists’ thoughts on different strategic approaches as ways. Then, the essay will delve …

Using Intentional Strategies To Promote Self-Efficacy In A Choral Classroom: An Action Research Study, Daniel Gutierrez

Graduate Theses/Dissertations

As a choral music educator, I investigated the impact of strategies I designed to foster self-efficacy in one of my choral classes. Drawing on Albert Bandura’s Social Cognitive Theory, I used enactive mastery, vicarious experience, verbal/social persuasion, and affective/physiological states to design specific classroom tasks that would serve as critical influences on an individual’s self-efficacy. The action research study was conducted with a mixed-gender choir class of grades 10-12 students, using Michael Zelenak’s Music Performance Self-Efficacy Scale as a pre-and post-survey measure. Observational and qualitative data were also collected to enable a reflective examination of teaching practices and student-teacher interactions.

Home-Based Electrical Stimulation To Accelerate Wound Healing-A Double-Blinded Randomized Control Trial, Alejandro Zulbaran-Rojas, Catherine Park, Nesreen El-Refaei, Brian Lepow, Bijan Najafi

Center on Aging Staff Publications

Background: Electrical stimulation (E-Stim) may offer a unique adjunctive treatment to heal complicated diabetic foot ulcers (DFU). Our primary goal is to examine the effectiveness of daily home-based E-Stim therapy to speed-up wound healing.

Methods: Patients with chronic DFUs and mild to severe peripheral arterial disease (PAD) were recruited and randomized to either control (CG) or intervention (IG) groups. The IG received 1-hour home-based E-Stim therapy on daily basis for 4 weeks (4W). E-Stim was delivered through electrical pads placed above the ankle joint using a bio-electric stimulation technology (BEST®) platform (Tennant Biomodulator® PRO). The CG was provided with an …

Syncretistic Religiosity In The Mausoleums Of Bangladesh: Exploring The Possibility Of A Blended Religious Identity, Sadia Afrin

Graduate Theses/Dissertations

Firstly, this thesis investigates the syncretistic religious nature of Bangladeshi mausoleums, along with the historical background of the Sufi mausoleums and the flourishment of this syncretistic religiosity. The study explores the contribution of Sufis to the spread of Islam in Bengal. It discusses how the liberal attitude of mausoleum enshrined Sufis toward their followers of diverse faiths patronized syncretism. The study here hypothesizes that the religious practices of Bangladeshi mausoleums are syncretistic; they are neither exclusively Muslim nor Hindu but present a blended identity. It demonstrates how religious syncretism is an undeniable phenomenon in the mausoleums of Bangladesh and how …

Exploration And Synthesis Of Half-Heusler And Disordered Ternary Intermetallic Single Crystals, Md Fahel Bin Noor

Graduate Theses/Dissertations

Due to their distinct physical and chemical characteristics, half-Heusler compounds are intermetallic materials that have undergone substantial research. The general formula for these compounds is XYZ, where X and Y are transition metals and Z is a p-block element. Thermoelectricity is among the half-Heusler compounds' most exciting potential uses, but additional possible applications include spintronics, magnetic refrigeration, and superconductivity, among others. Recently, half-Heuslers (and Heuslers) have emerged as candidates for catalysts for hydrogenation. The CoNbSn half-Heusler compound, as well as another unique intermetallic ternary compound, the disordered Mn_4-xCr_xAl₁₁, were successfully grown as single crystals …

Development Of A Clinical Prediction Model For Diabetes In Chronic Pancreatitis: The Predict3c Study, Christie Jeon, Phil A Hart, Liang Li, Yunlong Yang, Eleanor Chang, William E Fisher, Christopher E Forsmark, Walter G Park, Stephen K Van Den Eeden, Santhi Swaroop Vege, Jose Serrano, David C Whitcomb, Dana K Andersen, Darwin L Conwell, Dhiraj Yadav, Mark O Goodarzi

Faculty, Staff and Student Publications

Objective: Diabetes that arises from chronic pancreatitis (CP) is associated with increased morbidity and mortality. Methods to predict which patients with CP are at greatest risk for diabetes are urgently needed. We aimed to examine independent risk factors for diabetes in a large cohort of patients with CP.

Research design and methods: This cross-sectional study comprised 645 individuals with CP enrolled in the PROCEED study, of whom 276 had diabetes. We conducted univariable and multivariable regression analyses of potential risk factors for diabetes. Model performance was assessed by area under the receiver operating characteristic curve (AUROC) analysis, and accuracy was …

A Case Of Biventricular Hypertrophic Obstructive Cardiomyopathy: Echocardiographic Diagnosis, Michiyo Yamano, Takeshi Nakamura, Tetsuhiro Yamano, Satoaki Matoba

The Texas Heart Institute Journal

No abstract provided.

Surgical Reconstruction Of The Anomalous Left Coronary Artery From The Pulmonary Artery, Slobodan Micovic, Petar Milacic, Miroslav Milicic, Milica Brkovic, Petar Vukovic, Igor Zivkovic

The Texas Heart Institute Journal

The anomalous left coronary artery from the pulmonary artery is a rare congenital disease. Early surgical reconstruction is mandatory to prevent adverse cardiac events. Direct coronary button transfer, vein graft interposition, ligation, and coronary artery bypass construction are the most commonly used techniques. This case report presents a modified technique of Dacron graft interposition and reimplantation anomalous left coronary artery from the pulmonary artery on the ascending aorta.

Kounis Syndrome Associated With The Use Of Diclofenac, Ana V Pejcic, Milos N Milosavljevic, Slobodan Jankovic, Goran Davidovic, Marko M Folic, Nevena D Folic

The Texas Heart Institute Journal

BACKGROUND: Diclofenac is a widely used analgesic, anti-inflammatory, antipyretic drug. In several case reports, its use was associated with the occurrence of Kounis syndrome. The aim of this review was to investigate and summarize published cases of Kounis syndrome suspected to be associated with the use of diclofenac.

METHODS: Electronic searches were conducted in PubMed/MEDLINE, Scopus, Web of Science, Google Scholar, and the Serbian Citation Index.

RESULTS: Twenty publications describing the 20 patients who met inclusion criteria were included in the systematic review. Specified patient ages ranged from 34 to 81 years. Eighteen (90.0%) patients were male. Five patients (25.0%) …

Isolated Cardiac Paraganglioma Encasing Right Coronary Artery With Evidence Of Succinyl Dehydrogenase Gene Mutation: Successful Management Using Multimodality Imaging, Naveen Garg, Shashank Pandey, Shiva Madan, Subhash Yadav, Gurango Majumdar, Neeraj Jain, Manoj Jain

The Texas Heart Institute Journal

This report involves a young woman with isolated cardiac paraganglioma that was diagnosed using 68Gallium-labeled [1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid]-1-NaI3-octreotide positron emission tomographic scintigraphy. For the preoperative evaluation, multimodality imaging accurately described the anatomic location of the tumor and its relationship with the surrounding tissues. The patient underwent successful surgical resection of the tumor along with right coronary artery bypass grafting. The 2-month follow-up scintigraphy was normal. Next-generation sequencing evaluation revealed a novel germline mutation for the succinate dehydrogenase subunit B gene.

Editorial: The Regulatory Immune System As A Target To Improve Adjuvants And Novel Vaccines

Faculty, Staff and Students Publications

No abstract provided.

Specialized Intensive Inpatient Rehabilitation Is Crucial And Time-Sensitive For Functional Recovery From Disorders Of Consciousness, Bradley Chi, Colton Reeh, Sheng Li, Sunil Kothari

Faculty, Staff and Students Publications

Background: Disorders of consciousness (DoCs) after severe brain injury are considered to be conditions with dire prognosis. Despite the accumulating evidence, inpatient rehabilitation is often denied by payers referring to the Medicare/Medicaid criteria, under the assumption that such patients will not "actively" participate in therapy or make "measurable improvements."

Objective: This study aimed to report on the effectiveness and efficiency of a specialized inpatient DoC rehabilitation program based on measurable clinical parameters.

Methods: A retrospective cohort study was conducted. The cohort comprised 137 patients with DoC admitted to a specialized acute inpatient rehabilitation program between January …

Habenular Molecular Targets For Depression, Impulsivity, And Addiction

Faculty, Staff and Students Publications

No abstract provided.

Gastrointestinal Organoids In The Study Of Viral Infections, Jacob L Perry, Joseph M Hyser

Faculty, Staff and Students Publications

Viruses are among the most prevalent enteric pathogens. Although virologists historically relied on cell lines and animal models, human intestinal organoids (HIOs) continue to grow in popularity. HIOs are nontransformed, stem cell-derived, ex vivo cell cultures that maintain the cell type diversity of the intestinal epithelium. They offer higher throughput than standard animal models while more accurately mimicking the native tissue of infection than transformed cell lines. Here, we review recent literature that highlights virological advances facilitated by HIOs. We discuss the variations and limitations of HIOs, how HIOs have allowed for the cultivation of previously uncultivatable viruses, and how …

Symptoms, Physical Activity, And Biomarkers In Children At The End Of Leukemia Maintenance Therapy, Alicia S Kunin-Batson, Audrey Blommer, Jessica Hutter, Pauline Mitby, Ida Moore, Susan Whitman, Olga Taylor, Michael E Scheurer, Marilyn J Hockenberry

Faculty, Staff and Students Publications

Background: Symptoms in children with acute lymphocytic leukemia (ALL) change over the trajectory of treatment but little is known about their symptoms as treatment ends. Physical activity may help decrease symptom distress and is vital for ongoing development. The role of biomarkers in symptom science is emerging. The purpose of the study was to explore relationships between self-report of symptoms and physical activity, actigraphy measures, and cerebrospinal fluid (CSF) biomarkers.

Methods: Participants were children who were ages 3 to 18 years at the time of ALL diagnosis and were now in the last 12-week cycle of ALL maintenance. Self-reports of …

Fluorescence Lifetime Imaging Microscopy Of Biomolecular Condensates, Allan Chris M Ferreon

Faculty, Staff and Students Publications

Biomolecular condensates of ribonucleoproteins (RNPs) such as the transactivation response element (TAR) DNA-binding protein 43 (TDP-43) arise from liquid-liquid phase separation (LLPS) and play vital roles in various biological processes including the formation-dissolution of stress granules (SGs). These condensates are thought to be directly linked to neurodegenerative diseases, providing a depot of aggregation-prone proteins and serving as a cauldron of protein aggregation and fibrillation. Despite recent research efforts, biochemical processes and rearrangements within biomolecular condensates that trigger subsequent protein misfolding and aggregation remain to be elucidated. Fluorescence lifetime imaging microscopy (FLIM) provides a minimally intrusive high-sensitivity and high-resolution imaging method …

Changes In The Body Fluids Proteome As A Reflection Of The Physiological Effects Of Dry Immersion, I M Larina

Faculty, Staff and Students Publications

No abstract provided.

The Effect Of Different Warm-Up Durations On Subjective And Objective Measures Of Singing In Choral Singers Over The Age Of 55, Jeremy A. Chesman

Graduate Theses/Dissertations

Choral singing is a popular activity in the United States. Choral singers are often encouraged to warm up vocally before they sing. Considering voice conditions, like presbyphonia, that can develop shortly after retirement, more research about vocal warm-ups is needed for those over the age of 55. This study assesses the effects of various durations of vocal warm-ups on subjective and objective measures of the singing voice using a within-groups design with randomized condition order. Nine participants performed vocal warm-ups for 0, 5, 10, and 15 minutes. A song sample was then recorded and sent to two expert raters who …

A Comparison Of Peak Ground Reaction Forces Of Pitches From The Stretch And Windup, Richard D. Edwards

Graduate Theses/Dissertations

Ground reaction forces can help coaches and players understand the lower extremity biomechanics of pitching in baseball. Research has told us that there are repeatable characteristics of ground reaction forces that pitchers produce during a pitch. This study examines the differences in peak ground reaction forces produced from pitching from the stretch versus pitching from the wind-up. Five variables were recorded for each pitch from the push-off leg and the landing leg. Landing forces were then compared to landing forces of the other pitching style and the same comparison was made for the push-off leg. This was achieved by altering …

The Impact Of Profession On Depression, Weston David Phipps

Graduate Theses/Dissertations

Depression has long been a focused topic in the world of clinical psychology. While the exact nature of what drives an individual into depression has been difficult to determine, new at-risk populations are emerging every day, giving clinicians and businesses alike the opportunity to monitor their clients/workers health and stability more closely. The current study aims to examine the connections between individuals born into low resource environments and the likelihood of them taking on high-risk professions later in life. These high-risk professions are thought to be nurturing grounds for depressive symptoms when compared to lower risk professions. The current study’s …

Effect Of Color On License Plate Recall, Hannah R. Johnson

Graduate Theses/Dissertations

Accurate and quick license plate recall is important for identification purposes, especially in emergency situations, such as hit-and-runs. Previous research has shown that there are particular patterns of license plate designs that are easier to recall, such as a higher digit to letter ratio. Missouri license plate patterns (AB1-C2D) somewhat diverge from what research suggests works best for recall. The current study sought to determine if including color into license plate designs would improve recall. There were 48 undergraduate students from Missouri State University who participated in the experiment. Participants saw 100 timed trials of license plate stimuli, where they …

5-Meo-Dmt For Post-Traumatic Stress Disorder: A Real-World Longitudinal Case Study, Anya Ragnhildstveit, Ryan Khan, Paul Seli, Lisa Claire Bass, River Jude August, Miriam Kaiyo, Nathaniel Barr, Laura Kate Jackson, Michael Santo Gaffrey, Joseph Peter Barsuglia, Lynnette Astrid Averill

Center for Medical Ethics and Health Policy Staff Publications

Psychedelic therapy is, arguably, the next frontier in psychiatry. It offers a radical alternative to longstanding, mainstays of treatment, while exciting a paradigm shift in translational science and drug discovery. There is particular interest in 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT)—a serotonergic psychedelic—as a novel, fast-acting therapeutic. Yet, few studies have directly examined 5-MeO-DMT for trauma- or stress-related psychopathology, including post-traumatic stress disorder (PTSD). Herein, we present the first longitudinal case study on 5-MeO-DMT for chronic refractory PTSD, in a 23-year-old female. A single dose of vaporized bufotoxin of the Sonoran Desert Toad (Incilius alvarius), containing an estimated 10−15 mg …