Digital Commons Network^™

Clinical Applications Of Electrical Stimulation For Peripheral Nerve Injury: A Systematic Review, Meredith C Costello, Emily L Errante, Taylor Smartz, Wilson Z Ray, Allan D Levi, Stephen Shelby Burks

2020-Current year OA Pubs

INTRODUCTION: Peripheral nerve injuries are common neurologic injuries that are challenging to treat with current therapies. Electrical stimulation has been shown to accelerate reinnervation and enhance functional recovery. This study aims to review the literature on clinical application of electrical stimulation for peripheral nerve injury.

METHODS: PubMed and Embase were sourced from 1995 to August 2022. Selection was based on predetermined inclusion/exclusion criteria. Eight hundred and thirty-five articles were screened with seven being included in this review.

RESULTS: Two hundred and twenty-nine patients with peripheral nerve injuries were represented. Six of the studies were randomized controlled trials. A variety of …

Caregiver Perspectives On The Continued Impact Of The Covid-19 Pandemic On Children With Intellectual/Developmental Disabilities, R A Northrup, E Jones, V Singh, C Holingue, M Meck, C A Gurnett, M Van Stone, L G Kalb

2020-Current year OA Pubs

The COVID-19 pandemic has significantly impacted caregivers, especially those raising a child with an intellectual/developmental disability (IDD). While research has shown substantial disruption to the family, school, and occupational lives of the IDD community, little is known about the long-term impacts of COVID-19. To address this question, 249 caregivers were surveyed via an online questionnaire, between April and August of 2022 (more than 2 years into the pandemic) about potential impacts of the COVID-19 pandemic on their child's access to health- and school-based therapeutic services, caregiver mental health, and family life. The majority of caregivers reported disruptions in access to …

Characterization Of High-Gamma Activity In Electrocorticographic Signals, Johannes Gruenwald, Sebastian Sieghartsleitner, Christoph Kapeller, Josef Scharinger, Kyousuke Kamada, Peter Brunner, Christoph Guger

2020-Current year OA Pubs

INTRODUCTION: Electrocorticographic (ECoG) high-gamma activity (HGA) is a widely recognized and robust neural correlate of cognition and behavior. However, fundamental signal properties of HGA, such as the high-gamma frequency band or temporal dynamics of HGA, have never been systematically characterized. As a result, HGA estimators are often poorly adjusted, such that they miss valuable physiological information.

METHODS: To address these issues, we conducted a thorough qualitative and quantitative characterization of HGA in ECoG signals. Our study is based on ECoG signals recorded from 18 epilepsy patients while performing motor control, listening, and visual perception tasks. In this study, we first …

Genotype And Clinical Characteristics Of Patients With Wolfram Syndrome And Wfs1-Related Disorders, Evan M Lee, Megha Verma, Nila Palaniappan, Emiko M Pope, Sammie Lee, Lindsey Blacher, Pooja Neerumalla, William An, Toko Campbell, Cris Brown, Stacy Hurst, Bess Marshall, Tamara Hershey, Fumihiko Urano, Et Al.

2020-Current year OA Pubs

No abstract provided.

Therapeutic Activity Of Lipoxin A4 In Tio2-Induced Arthritis In Mice: Nf-Κb And Nrf2 In Synovial Fluid Leukocytes And Neuronal Trpv1 Mechanisms, Telma Saraiva-Santos, Tiago H Zaninelli, Felipe A Pinho-Ribeiro, Et Al.

2020-Current year OA Pubs

BACKGROUND: Lipoxin A4 (LXA

METHODS: Mice were stimulated with TiO

RESULTS: LXA

CONCLUSION: LXA

T-Cell Redirecting Therapies For B-Cell Non-Hodgkin Lymphoma: Recent Progress And Future Directions, David A Russler-Germain, Armin Ghobadi

2020-Current year OA Pubs

Several key advances in the treatment of B-cell non-Hodgkin lymphoma (B-NHL) over the past two decades have strategically exploited B-cell lineage markers suitable for targeting by immunotherapies. First, the addition of the anti-CD20 monoclonal antibody (mAb) rituximab to a range of standard therapies conferred remarkable outcomes improvements in diverse settings, perhaps most prominently an overall survival advantage in newly diagnosed diffuse large B-cell lymphoma (DLBCL). Subsequently, multiple chimeric antigen receptor (CAR) T-cell therapies targeting CD19 have revolutionized the treatment of relapsed/refractory (rel/ref) DLBCL and are active in other B-NHL subtypes as well. Most recently, the longstanding aspiration to exploit patients' …

Clinical Characteristics And Outcomes Of Infection With Human T-Lymphotropic Virus In A Non-Endemic Area: A Single Institution Study, Margery Gang, Feng Gao, Sneha Poondru, Theodore Thomas, Lee Ratner

2020-Current year OA Pubs

INTRODUCTION: Understanding of human T-lymphotropic virus (HTLV) remains largely based on epidemiologic and clinical data from endemic areas. Globalization has resulted in migration of persons living with HTLV (PLHTLV) from endemic to non-endemic areas, and a rise of HTLV infection in the United States. Yet, due to the historical rarity of this disease, affected patients are often under- and mis-diagnosed. Thus, we sought to characterize the epidemiology, clinical features, comorbidities, and survival of HTLV-1- or HTLV-2-positive individuals identified in a non-endemic area.

METHODS: Our study was a single institution, retrospective case-control analysis of HTLV-1 or HTLV-2 patients between 1998 and …

Financial Burden Of Men With Localized Prostate Cancer: A Process Paper, Ashley J Housten, Hannah E Rice, Su-Hsin Chang, Allison J L'Hotta, Eric H Kim, Bettina F Drake, Robin Wright-Jones, Mary C Politi

2020-Current year OA Pubs

BACKGROUND: Many individuals undergoing cancer treatment experience substantial financial hardship, often referred to as financial toxicity (FT). Those undergoing prostate cancer treatment may experience FT and its impact can exacerbate disparate health outcomes. Localized prostate cancer treatment options include: radiation, surgery, and/or active surveillance. Quality of life tradeoffs and costs differ between treatment options. In this project, our aim was to quantify direct healthcare costs to support patients and clinicians as they discuss prostate cancer treatment options. We provide the transparent steps to estimate healthcare costs associated with treatment for localized prostate cancer among the privately insured population using a …

The Evaluation Of The Delayed Swollen Breast In Patients With A History Of Breast Implants, Grace C Keane, Alexandra M Keane, Ryan Diederich, Kaitlyn Kennard, Eric J Duncavage, Terence M Myckatyn

2020-Current year OA Pubs

Breast implants, whether placed for reconstructive or cosmetic purposes, are rarely lifetime devices. Rupture, resulting from compromised implant shell integrity, and capsular contracture caused by constriction of the specialized scar tissue that normally forms around breast implants, have long been recognized, and remain the leading causes of implant failure. It is apparent, however, that women with breast implants may also experience delayed breast swelling due to a range of etiologic factors. While a majority of delayed seromas associated with breast implants have a benign etiology, this presentation cannot be ignored without an adequate workup as malignancies such as breast implant …

Functional Trajectories During Innate Spinal Cord Repair, Nicholas O Jensen, Brooke Burris, Lili Zhou, Hunter Yamada, Catrina Reyes, Zachary Pincus, Mayssa H Mokalled

2020-Current year OA Pubs

Adult zebrafish are capable of anatomical and functional recovery following severe spinal cord injury. Axon growth, glial bridging and adult neurogenesis are hallmarks of cellular regeneration during spinal cord repair. However, the correlation between these cellular regenerative processes and functional recovery remains to be elucidated. Whereas the majority of established functional regeneration metrics measure swim capacity, we hypothesize that gait quality is more directly related to neurological health. Here, we performed a longitudinal swim tracking study for 60 individual zebrafish spanning 8 weeks of spinal cord regeneration. Multiple swim parameters as well as axonal and glial bridging were integrated. We …

Cell Wall Composition In Cryptococcus Neoformans Is Media Dependent And Alters Host Response, Inducing Protective Immunity, Rajendra Upadhya, Woei C Lam, Camaron R Hole, Joseph G Vasselli, Jennifer K Lodge

2020-Current year OA Pubs

INTRODUCTION:

OBJECTIVE: The purpose of this study was to determine how different media influenced the amount of chitin and chitosan in the cell wall, which in turn impacted the cell wall architecture and host response.

METHODS: Yeast extract, peptone, and dextrose (YPD) and yeast nitrogen base (YNB) are two commonly used media for growing Cryptococcus before use in in vitro or in vivo experiments. As a result,

RESULTS: We observed that the growth of wild-type

CONCLUSION: These findings emphasize the importance of culture media and pH during growth in shaping the content and organization of the

Changes In Patient-Reported Pain Interference After Surgical Treatment Of Painful Lower Extremity Neuromas, Adam Liebendorfer, Esther Ochoa, Christopher J Dy

2020-Current year OA Pubs

PURPOSE: Painful neuromas commonly cause neuropathic pain, in up to 1 in 20 cases of traumatic or iatrogenic nerve injury. Despite the multiple surgical treatment types that reduce pain, no type has been universally accepted.

METHODS: We performed a retrospective cohort study by administering follow-up surveys to all surgical patients treated in our department for lower-extremity neuroma from September 1, 2015, to October 22, 2021, that could be contacted, excluding those with Morton neuroma. In addition to the Patient-Reported Outcomes Measurement Information System (PROMIS) Pain Interference (PI) questionnaire, survey questions covered the time to pain reduction, use of physical or …

A Universal Neocortical Mask For Centiloid Quantification, Pierrick Bourgeat, Vincent Doré, Christopher C Rowe, Tammie Benzinger, Duygu Tosun, Manu S Goyal, Pamela Lamontagne, Liang Jin, Michael W Weiner, Colin L Masters, Jurgen Fripp, Victor L Villemagne, Alzheimer's Disease Neuroimaging Initiative; Oasis3, Aibl Research Group

2020-Current year OA Pubs

INTRODUCTION: The Centiloid (CL) project was developed to harmonize the quantification of amyloid beta (Aβ) positron emission tomography (PET) scans to a unified scale. The CL neocortical mask was defined using

METHODS: Using data from the Alzheimer's Dementia Onset and Progression in International Cohorts (ADOPIC) study (Australian Imaging Biomarkers and Lifestyle + Alzheimer's Disease Neuroimaging Initiative + Open Access Series of Imaging Studies), age-matched pairs of mild Alzheimer's disease (AD) and healthy controls (HC) were selected:

RESULTS: In the GAAIN dataset, the universal mask led to a small reduction in the variance of the YC, and a small increase in …

Toward A Computational Theory Of Manifold Untangling: From Global Embedding To Local Flattening, Xin Li, Shuo Wang

2020-Current year OA Pubs

It has been hypothesized that the ventral stream processing for object recognition is based on a mechanism called cortically local subspace untangling. A mathematical abstraction of object recognition by the visual cortex is how to untangle the manifolds associated with different object categories. Such a manifold untangling problem is closely related to the celebrated kernel trick in metric space. In this paper, we conjecture that there is a more general solution to manifold untangling in the topological space without artificially defining any distance metric. Geometrically, we can either

A Word From The Writing Team (January 2023), Pam Walter, Mfa, Liz Declan, Ma, Mfa

A Word From the Writing Team (Newsletter)

This issue includes:

• New Year, Monthly Writing Sessions
• Upcoming Workshops

Probabilistic Solutions Of Fractional Differential And Partial Differential Equations And Their Monte Carlo Simulations, Tamer Oraby, Erwin Suazo, Harrinson Arrubla

School of Mathematical & Statistical Sciences Faculty Publications

The work in this paper is four-fold. Firstly, we introduce an alternative approach to solve fractional ordinary differential equations as an expected value of a random time process. Using the latter, we present an interesting numerical approach based on Monte Carlo integration to simulate solutions of fractional ordinary and partial differential equations. Thirdly, we show that this approach allows us to find the fundamental solutions for fractional partial differential equations (PDEs), in which the fractional derivative in time is in the Caputo sense and the fractional in space one is in the Riesz–Feller sense. Lastly, using Riccati equation, we …

Classification On Boundary-Equilibria And Singular Continuums Of Continuous Piecewise Linear Systems, Hebai Chen, Zhaosheng Feng, Hao Yang, Linfeng Zhou

School of Mathematical & Statistical Sciences Faculty Publications

In this paper, we show that any switching hypersurface of n -dimensional continuous piecewise linear systems is an (n−1) -dimensional hyperplane. For two-dimensional continuous piecewise linear systems, we present local phase portraits and indices near the boundary equilibria (i.e. equilibria at the switching line) and singular continuum (i.e. continuum of nonisolated equilibria) between two parallel switching lines. The index of singular continuum is defined. Then we show that boundary-equilibria and singular continuums can appear with many parallel switching lines.

Quantization For A Set Of Discrete Distributions On The Set Of Natural Numbers, Juan Gomez, Haily Martinez, Mrinal Kanti Roychowdhury, Alexis Salazar, Daniel J. Vallez

School of Mathematical & Statistical Sciences Faculty Publications

The quantization scheme in probability theory deals with finding a best approximation of a given probability distribution by a probability distribution that is supported on finitely many points. In this paper, first we state and prove a theorem, and then give a conjecture. We verify the conjecture by a few examples. Assuming that the conjecture is true, for a set of discrete distributions on the set of natural numbers we have calculated the optimal sets of n-means and the nth quantization errors for all positive integers n. In addition, the quantization dimension is also calculated.

Final Report: Conceptualizing Ethics, Authenticity, And Efficacy Of Simulations In Teacher Education, Carrie Wilkerson Lee, Liza Bondurant, Bima Sapkota, Heather Howell, Yvonne Lai

School of Mathematical & Statistical Sciences Faculty Publications

This working group was a continuation of working groups in 2019 and 2021 that initially aimed to focus on equity in simulations of practice in mathematics teacher education. We began by discussing our conceptualizations of simulations and equity. Next, we reflected on the lack of work that currently exists at the intersection of simulations and equity as well as our limited collective expertise in this space. We proposed the following areas of potential research: Access, Design, Affective Domains, Teaching Practices, Assessment, Critical Conversations. Attendees self-selected into focus groups and met to discuss their current work and how future work could …

Numerical Study Of Sediment Suspension Affected By Rigid Cylinders Under Unidirectional And Combined Wave-Current Flows, Sha Lou, Xiaolan Chen, Shengyu Zhou, Gangfeng Ma, Shuguang Liu, Larisa Dorzhievna Radnaeva, Elena Nikitina, Irina Viktorovna Fedorova

Civil & Environmental Engineering Faculty Publications

Sediment transport modeling for flows with cylinders is very challenging owing to the complicated flow–cylinder–sediment interactions, especially under the combined wave-current flows. In this paper, an improved formulation for incipient sediment suspension considering the effect of cylinder density (i.e., solid volume fraction) is employed to simulate the bottom sediment flux in the flow with cylinders. The proposed model is calibrated and validated using laboratory measurements under unidirectional and combined wave-current flows in previous studies. It is proved that the effects of cylinders on sediment suspension can be accounted for through a modified critical Shields number, and the proposed model is …

Elastoplastic Quasi-Static And Impact Load Response Of Steel Structure Sub-Assemblage With Cfrp Strips, Ali Al Aloosi, Zia Razzaq

Civil & Environmental Engineering Faculty Publications

Presented in this paper is the outcome of an experimental investigation of the elastoplastic quasi-static and impact load response of a steel sub-assemblage constructed using a pair of hollow square section members with or without Carbon Fiber Reinforced Polymer (CFRP) strips. The sub-assemblage consists of a long structural member welded to a short member, thus representing a typical combination of a column and a beam on the face of a multi-story steel building frame. The column is subjected to a lateral quasi-static or impact load. Tests are conducted on four separate steel sub-assemblages. The first two tests are conducted with …

Higher-Order Effects In Biaxial Flexure Of Gfrp I-Section Beams, Zia Razzaq, Faridoon Z. Razzaq

Civil & Environmental Engineering Faculty Publications

A theoretical study of Glass Fiber Reinforced Polymer (GFRP) beams subjected to biaxial bending moments is presented with a focus on the influence of higher-order effects on maximum normal stresses. It is shown that the biaxial bending type of loading causes a dramatic increase in the maximum normal stress for a GFRP beam when induced torsional effects are included. The study demonstrates that the traditional first-order theory can grossly underestimate the maximum normal stress in a GFRP beam. Based on the numerical results presented using a higher-order theory which also accounts for induced warping normal stresses, the maximum normal stress …

Modeling The Production Of Microalgal Biomass In Large Water Resource Recovery Facilities And Its Processing Into Various Commodity Bioproducts, James Pierson, Gopi Raju Makkena, Sandeep Kumar, Vinod Kumar, Vivekanand Vivekanand, Hasan Husain, Muhammad Ayser, Venkatesh Balan

Civil & Environmental Engineering Faculty Publications

Algae are capable of sequestering nutrients such as nitrates and phosphates from wastewater in the presence of sunlight and carbon dioxide (CO₂) to build up their body mass and help combat climate change. In the current study, we carried out different case studies to estimate the volume of algal biomass that could be produced annually using the rotating algal biofilm (RAB) method in three large-scale water resource recovery facilities (WRRFs) in Texas: Fort Worth, Dallas, and Houston. We calculated the total amount of lipids, carbohydrates, and proteins that could be fractionated from the algal biomass while using the …

How Class Matters: Examining Working-Class Children’S Home Technology Environments From A Developmental Perspective, Vikki Katz, Brianna Hightower

Communication Faculty Articles and Research

Social class is seldom engaged by scholars as a lens for investigating variations in children’s digital technology engagement. Drawing on semi-structured interviews with 33 working-class children in a postindustrial community, we examine how social class shapes these children’s digital technology experiences. Bronfenbrenner’s ecological theory of child development guides our examination of children’s views on digital technology integration into their interactions with proximal influences (i.e., parents, siblings, and friends) and distal influences that indirectly shape their technology environments by affecting their parents’ circumstances. We find that working-class children’s experiences share key commonalities with both their lower- and higher-income peers, consistent with …

Poo Matters! A Scoping Review Of Impact Of Constipation On Epilepsy, Alexandra Gabrielsson, Samuel Tromans, Lance Watkins, Lisa Burrows, Richard Laugharne, Rohit Shankar

Peninsula Medical School

BACKGROUND: Epilepsy is a common neurological disorder which frequently presents with co-morbid physical health conditions, including constipation. However, the nature of the relationship between the two conditions has not been well defined. AIM: To quantify constipation's relationship with epilepsy and anti-seizure medication (ASM). METHOD: A scoping review registered on PROSPERO (CRD42022320079) with suitable search terms was conducted and reported in accordance with PRISMA guidance. CINAHL, Embase, PsycInfo and MEDLINE electronic databases were searched by an information specialist. The Joanna Briggs Institute (JBI) critical appraisal tools alongside the Oxford Centre for Evidence Based Medicine (OCEBM) levels of evidence were used to …

Topical Review: Optometry In Nepal—Clinical Practice, Research Advances, And Challenges, Safal Khanal, Nabin Paudel, Rabindra Adhikary, Mahesh Raj Joshi

School of Health Professions

SIGNIFICANCE This article reviews educational standard, clinical practice, research advances, and challenges associated with optometry in Nepal and provides critical considerations for contemporary and new optometry programs in countries with similar socioeconomic status and health care systems. Optometry education started in Nepal in 1998 with the primary objective of addressing the unmet needs of eye health and vision care in the country. Over the last two decades, this program has made significant contributions to facilitating and improving the delivery of quality eye care and establishing the nation's eye health system as an exemplary model in South Asia. Despite the positive …

Dead-Zone Compensation Via Passivity-Based Control For A Class Of Mechanical Systems, Carmen Chan-Zheng, Pablo Borja, Jacquelien M.A. Scherpen

School of Engineering, Computing and Mathematics

This manuscript introduces a passivity-based control methodology for fully-actuated mechanical systems with symmetric or asymmetric dead-zones. To this end, we find a smooth approximation of the inverse of the function that describes such a nonlinearity. Then, we propose an energy and damping injection approach — based on the PI-PBC technique — that compensates for the dead-zone. Moreover, we provide an analysis of the performance of the proposed controller near the equilibrium. We conclude this paper by experimentally validating the results on a two degrees-of-freedom planar manipulator.

Instability Of Waves In Deep Water — A Discrete Hamiltonian Approach, David Andrade, Raphael Stuhlmeier

School of Engineering, Computing and Mathematics

The stability of waves in deep water has classically been approached via linear stability analysis, with various model equations, such as the nonlinear Schrödinger equation, serving as points of departure. Some of the most well-studied instabilities involve the interaction of four waves – so called Type I instabilities – or five waves – Type II instabilities. A unified description of four and five wave interaction can be provided by the reduced Hamiltonian derived by Krasitskii (1994). Exploiting additional conservation laws, the discretised Hamiltonian may be used to shed light on these four and five wave instabilities without restrictions on spectral …

Air Quality And Mental Health: Evidence, Challenges And Future Directions, Kamaldeep Bhui, Joanne B. Newbury, Rachel M. Latham, Marcella Ucci, Zaheer A. Nasir, Briony Turner, Catherine O'Leary, Helen L. Fisher, Emma Marczylo, Philippa Douglas, Stephen Stansfeld, Simon K. Jackson, Sean Tyrrel, Andrey Rzhetsky, Rob Kinnersley, Prashant Kumar, Caroline Duchaine, Frederic Coulon

School of Biomedical Sciences

Background Poor air quality is associated with poor health. Little attention is given to the complex array of environmental exposures and air pollutants that affect mental health during the life course. Aims We gather interdisciplinary expertise and knowledge across the air pollution and mental health fields. We seek to propose future research priorities and how to address them. Method Through a rapid narrative review, we summarise the key scientific findings, knowledge gaps and methodological challenges. Results There is emerging evidence of associations between poor air quality, both indoors and outdoors, and poor mental health more generally, as well as specific …

Transition Theory And The Emotional Journey To Medical Educator Identity: A Qualitative Interview Study, J Browne, T Collett

Peninsula Medical School

Background. Medical academia is in crisis, with fewer people entering and growing concern at numbers leaving. While faculty development is often seen as part of the solution, there are significant issues with faculty not engaging with and resisting development opportunities. Lack of motivation may be linked to what might be called a ‘weak’ educator identity. We studied medical educators' experiences of career development to gain further insights into: how professional identity may develop; individuals' accompanying emotional responses to perceived identity change; and consideration of the accompanying temporal dimensions. Drawing on new materialist sociology, we explore medical educator identity formation in …