Digital Commons Network^™

Self-Administered Meditation Application Intervention For Cancer Patients With Psychosocial Distress: A Pilot Study, Gabriel Lopez, Alejandro Chaoul, Carla L Warneke, Aimee J Christie, Catherine Powers-James, Wenli Liu, Santhosshi Narayanan, Marvin Delgado-Guay, Yisheng Li, Eduardo Bruera, Lorenzo Cohen

Faculty, Staff and Student Publications

BACKGROUND: We explored the use of a novel smart phone-based application (APP) for delivery and monitoring of meditation to treat mood symptoms experienced by cancer patients.

METHODS: We assessed the feasibility of using a meditation delivery and tracking APP over 2-weeks and its impact on cancer patients' self-reported anxiety and depression. Outpatients reporting depression and/or anxiety were recruited and randomized to the APP or waitlist control group. Assessments included an expectancy scale, exit survey, mood rating before and after each meditation, and the Edmonton Symptom Assessment Scale (ESAS-FS), Hospital Anxiety and Depression Scale (HADS), and Pittsburgh Sleep Quality Index (PSQI) …

Severe Radiation-Induced Lymphopenia During Concurrent Chemoradiotherapy For Stage Iii Non-Small Cell Lung Cancer: External Validation Of Two Prediction Models, Peter S N Van Rossum, Celia Juan-Cruz, Barbara Stam, Maddalena M G Rossi, Steven H Lin, Azadeh Abravan, José S A Belderbos, Jan-Jakob Sonke

Faculty, Staff and Student Publications

BACKGROUND: Severe radiation-induced lymphopenia (RIL) in patients undergoing chemoradiotherapy (CRT) for non-small cell lung cancer (NSCLC) is associated with decreased immunotherapy efficacy and survival. At The Christie and MD Anderson Cancer Center (MDACC), prediction models for lymphopenia were developed in lung and esophageal cancer patients, respectively. The aim of this study was to externally validate both models in patients with stage III NSCLC.

METHODS: Patients who underwent concurrent CRT for stage III NSCLC in 2019-2021 were studied. Outcomes were grade ≥3 and grade 4 lymphopenia during CRT. The Christie model predictors for grade ≥3 lymphopenia included age, baseline lymphocyte count, …

Potential Chemoprotective Effects Of Active Ingredients In Salvia Miltiorrhiza On Doxorubicin-Induced Cardiotoxicity: A Systematic Review Of In Vitro And In Vivo Studies, Qingqing Wang, Jiaxian Li, Xuelei Chu, Xiaochen Jiang, Chuanlong Zhang, Fudong Liu, Xiyuan Zhang, Yi Li, Qian Shen, Bo Pang

Faculty, Staff and Student Publications

BACKGROUND: Recently, attention has been paid to the protective properties of active ingredients in

METHODS: According to the PRISMA guideline, the current systematic review was conducted in the Web of Science, PubMed, Embase, and the Cochrane Library to collect all relevant

RESULTS: Twenty-two eligible articles were included in this systematic review. Eleven types of active ingredients in

CONCLUSION: This systematic review demonstrated that AISM have chemoprotective effects on DIC

Pepsim: T-Cell Cross-Reactivity Prediction Via Comparison Of Peptide Sequence And Peptide-Hla Structure, Sarah Hall-Swan, Jared Slone, Mauricio M Rigo, Dinler A Antunes, Gregory Lizée, Lydia E Kavraki

Faculty, Staff and Student Publications

INTRODUCTION: Peptide-HLA class I (pHLA) complexes on the surface of tumor cells can be targeted by cytotoxic T-cells to eliminate tumors, and this is one of the bases for T-cell-based immunotherapies. However, there exist cases where therapeutic T-cells directed towards tumor pHLA complexes may also recognize pHLAs from healthy normal cells. The process where the same T-cell clone recognizes more than one pHLA is referred to as T-cell cross-reactivity and this process is driven mainly by features that make pHLAs similar to each other. T-cell cross-reactivity prediction is critical for designing T-cell-based cancer immunotherapies that are both effective and safe. …

The Cx3cl1-Cx3cr1 Chemokine Axis Can Contribute To Tumor Immune Evasion And Blockade With A Novel Cx3cr1 Monoclonal Antibody Enhances Response To Anti-Pd-1 Immunotherapy, Apoorvi Chaudhri, Xia Bu, Yunfei Wang, Michael Gomez, James A Torchia, Ping Hua, Shao-Hsi Hung, Michael A Davies, Gregory A Lizee, Ulrich Von Andrian, Patrick Hwu, Gordon J Freeman

Faculty, Staff and Student Publications

CX3CL1 secreted in the tumor microenvironment serves as a chemoattractant playing a critical role in metastasis of CX3CR1 expressing cancer cells. CX3CR1 can be expressed in both cancer and immune-inhibitory myeloid cells to facilitate their migration. We generated a novel monoclonal antibody against mouse CX3CR1 that binds to CX3CR1 and blocks the CX3CL1-CX3CR1 interaction. We next explored the immune evasion strategies implemented by the CX3CL1-CX3CR1 axis and find that it initiates a resistance program in cancer cells that results in 1) facilitation of tumor cell migration, 2) secretion of soluble mediators to generate a pro-metastatic niche, 3) secretion of soluble …

Resveratrol Rescues Cutaneous Radiation-Induced Dna Damage Via A Novel Ampk/Sirt7/Hmgb1 Regulatory Axis, Yi Jin, Xingyuan Liu, Xiaoting Liang, Jiabin Liu, Jieyu Liu, Zonglin Han, Qianxin Lu, Ke Wang, Bingyao Meng, Chunting Zhang, Minna Xu, Jian Guan, Li Ma, Liang Zhou

Faculty, Staff and Student Publications

Cutaneous radiation injury (CRI) interrupts the scheduled process of radiotherapy and even compromises the life quality of patients. However, the current clinical options for alleviating CRI are relatively limited. Resveratrol (RSV) has been shown to be a promising protective agent against CRI; yet the mechanisms of RSV enhancing radioresistance were not fully elucidated and limited its clinical application. In this study, we demonstrate RSV promotes cutaneous radioresistance mainly through SIRT7. During ionizing radiation (IR) treatment, RSV indirectly phosphorylates and activates SIRT7 through AMPK, which is critical for maintaining the genome stability of keratinocytes. Immunoprecipitation and mass spectrometry identified HMGB1 to …

Internet Of Things (Iot)-Based Teaching And Learning: Modern Trends And Open Challenges, Ibrahim Ahmed Ghashim, Muhammad Arshad

Research Outputs: 2025-Present

The effect of technology has caused many institutions to intend to change their approach to teaching and learning, resulting in the current model of teaching and learning being an active collaborative and self-directed one. The connection between education and technology has received attention as part of educational policy and practice. Debatable topics like how to use technology in the classroom have therefore punctuated complaints about declining educational standards, unemployed learners, duplicate curricula, and archaic institutional structure. In the framework of information and communication technologies and societal growth, the Internet of Things (IoT) is asserting its vital position. Institutions may improve …

Global Research Trends And Prospects Related To Tumor Microenvironment Within Triple Negative Breast Cancer: A Bibliometric Analysis, Peiting Li, Jun Li, Xiaofei Tong, Zhenyang Xiao, Wuliang Diao, Chi Zhong, Jianda Zhou, Wei Wu

Faculty, Staff and Student Publications

Background and aims: The tumor microenvironment (TME) has pivotal parts within multiple tumor models of onset/progression, such as triple-negative breast cancer (TNBC). This bibliometric analysis was developed to explore trends and research niches revolving around TME in TNBC.

Methods: Web of Science Core Collection was queried for identifying studies linked with TME in TNBC, after which the VOSviewer, CiteSpace, and R software programs were used to conduct bibliometric analyses and to generate corresponding visualizations.

Results: In total, this study included 1,604 studies published from 2005-2023. The USA and China exhibited the highest numbers of citations, and the research institutions with …

Mri And Amino Acid Pet Detection Of Whole-Brain Tumor Burden, Peng Chen, Matthew L Scarpelli, Debbie R Healey, Shwetal Mehta, C Chad Quarles

Faculty, Staff and Student Publications

Background: [18F]fluciclovine amino acid PET has shown promise for detecting brain tumor regions undetected on conventional anatomic MRI scans. However, it remains unclear which of these modalities provides a better assessment of the whole brain tumor burden. This study quantifies the performance of [18F]fluciclovine PET and MRI for detecting the whole brain tumor burden.

Methods: Thirteen rats were orthotopically implanted with fluorescently transduced human glioblastoma cells. Rats underwent MRI (T1- and T2-weighted) and [18F]fluciclovine PET. Next brains were excised, optically cleared, and scanned ex vivo with fluorescence imaging. All images were co-registered using a novel landmark-based registration to enable a …

A Cross-Sectional Study To Test Equivalence Of Low- Versus Intermediate-Flip Angle Dynamic Susceptibility Contrast Mri Measures Of Relative Cerebral Blood Volume In Patients With High-Grade Gliomas At 15 Tesla Field Strength, Mark S Shiroishi, Dane Weinert, Steven Y Cen, Bino Varghese, Timothy Dondlinger, Melissa Prah, Jesse Mendoza, Sina Nazemi, Nima Ameli, Negin Amini, Salman Shohas, Shannon Chen, Bavrina Bigjahan, Gabriel Zada, Thomas Chen, Josh Neman-Ebrahim, Eric L Chang, Frances E Chow, Zhaoyang Fan, Wensha Yang, Frank J Attenello, Jason Ye, Paul E Kim, Vishal N Patel, Alexander Lerner, Jay Acharya, Leland S Hu, C Chad Quarles, Jerrold L Boxerman, Ona Wu, Kathleen M Schmainda

Faculty, Staff and Student Publications

INTRODUCTION: 1.5 Tesla (1.5T) remain a significant field strength for brain imaging worldwide. Recent computer simulations and clinical studies at 3T MRI have suggested that dynamic susceptibility contrast (DSC) MRI using a 30° flip angle ("low-FA") with model-based leakage correction and no gadolinium-based contrast agent (GBCA) preload provides equivalent relative cerebral blood volume (rCBV) measurements to the reference-standard acquisition using a single-dose GBCA preload with a 60° flip angle ("intermediate-FA") and model-based leakage correction. However, it remains unclear whether this holds true at 1.5T. The purpose of this study was to test this at 1.5T in human high-grade glioma (HGG) …

Methodological Considerations In Pisces 3: A Randomized, Placebo-Controlled Study Of Intracerebral Stem Cells In Subjects With Disability Following An Ischemic Stroke, Daniel T Laskowitz, Keith W Muir, Sean I Savitz, Lawrence R Wechsler, Julie G Pilitsis, Scott Y Rahimi, Richard L Beckman, Vincent Holmes, Peng R Chen, Laura Juel, Deborah Koltai, Brad J Kolls

Faculty, Staff and Student Publications

Background and hypothesis: At present, there are no medical interventions proven to improve functional recovery in patients with subacute stroke. We hypothesize that the intraparenchymal administration of CTX0E03, a conditionally immortalized neural stem cell line, linked with a standardized rehabilitation therapy regimen for the upper limb, would improve functional outcomes in patients 6-12 months after an index ischemic stroke.

Study design: PISCES III was designed as a multicenter prospective, sham-controlled, outcome-blinded randomized clinical trial. Eligibility required a qualifying ischemic stroke 6-12 months prior to surgical intervention. Patients must be between 35 and 75 years of age and have residual moderate …

The Way We Live Now, Angela Piccini, Joanne Dorothea-Smith, Sefryn Penrose

School of Art, Design and Architecture

This gathering of 50 stakeholders in Plymouth was the outcome of an IAA project that was a collaboration with The Box to investigate the potential for a city-wide exhibition to celebrate the 80th anniversary of Jill Craigie's 1946 film, The Way We Live. We undertook a close analysis of the film itself to identify key themes; desk-based research to identify community groups, organisations, artists and scholars with interests in the key themes of the film; and we organised a day-long workshop and screening that brought people together to share our research findings and explore potential for further projects. The resulting …

Unlocking Social Innovation In Xr For Healthcare In Coastal Communities, Alejandro Veliz Reyes, Marius N. Varga, Hannah Bradwell, Rory Baxter

School of Art, Design and Architecture

This position paper reconsiders the 'social' aspect of XR systems for healthcare, often developed following a 'problem-solution' approach that neglects sociocultural factors affecting their codesign and successful adoption. Focusing on coastal and rural communities, we review and present key principles to consider when codesigning XR systems with marginalised groups. Our work stems from two projects funded by UK Research & Innovation that aim to promote healthy ageing in coastal communities.

Variability In Feeding Habitats Of Red Deer Sensu Lato In Eurasia In The Late Pleistocene And Holocene, Maciej Sykut, Sławomira Pawełczyk, Natalia Piotrowska, Krzysztof Stefaniak, Bogdan Ridush, Daniel Makowiecki, Pavel Kosintsev, Barbara Wilkens, Tomasz Borowik, Ralph Fyfe, Jessie Woodbridge, Magdalena Niedziałkowska

School of Geography, Earth and Environmental Sciences

Red deer (Cervus elaphus) is one of the species that is rather wide spread and survived across Europe over the Holocene. The analyses of carbon and nitrogen stable isotopes in bone collagen of ungulate remains have been applied in paleoecological studies as environmental and dietary indicators. In this study we present the carbon and nitrogen stable isotope compositions of previously radiocarbon-dated red deer bone samples (N = 68) found in Central, Southern and Eastern Europe and Asia and aligned to one of two species: European red deer (Cervus elaphus) and wapiti (Cervus canadensis). We showed that the values of carbon …

Legacy Radionuclides In Cryoconite And Proglacial Sediment On Orwell Glacier, Signy Island, Antarctica, Philip N. Owens, Tim A. Stott, Will H. Blake, Geoffrey E. Millward

School of Geography, Earth and Environmental Sciences

Cryoconite is a specific type of material found on the surface of glaciers and icesheets. Samples of cryoconite were collected from the Orwell Glacier and its moraines, together with suspended sediment from the proglacial stream on Signy Island, part of the South Orkney Islands, Antarctica. The activity concentrations of certain fallout radionuclides were determined in the cryoconite, moraine and suspended sediment, in addition to particle size composition and %C and %N. For cryoconite samples (n = 5), mean activity concentrations (±1SD) of 137Cs, 210Pbun and 241Am were 13.2 ± 20.9, 66.1 ± 94.0 and 0.32 ± 0.64 Bq kg−1, respectively. …

The Propagation And Emplacement Mechanisms Of The Tenteniguada Volcanic Debris Avalanche (Gran Canaria): Field Evidence For Brittle Fault-Accommodated Spreading, Symeon Makris, Matteo Roverato, Alejandro Lomoschitz, Paul Cole, Irene Manzella

School of Geography, Earth and Environmental Sciences

The Tenteniguada volcanic debris avalanche deposit is located on the east of the island of Gran Canaria, Spain. Its internal structure is composed of a complex assemblage of extensional features and shearing structures including normal faults, horst and graben, brittle/ductile boudinage and clastic dike injections. Examination of these features in the field and evaluation of their distribution have allowed the generation of a new conceptual model for the transport and emplacement of this debris avalanche, and potentially others. In the majority of the deposit, the degree of disaggregation is low, with large portions of the original edifice preserved, although displaced …

Abandonment Of Fibreglass Reinforced Plastic Fishing Boats In Kerala, India, And Chemical Emissions Arising From Their Burning, N. Manju Lekshmi, Sreejith S. Kumar, P. Muhamed Ashraf, K. A.Martin Xavier, K. P. Prathish, S. V. Ajay, Leela Edwin, Andrew Turner

School of Geography, Earth and Environmental Sciences

Little information exists on the fate and impacts of boats constructed of fibreglass reinforced plastic (FRP) once they reach their end-of-life. In this study, the number of abandoned fishing boats constructed of FRP or constructed of plywood-wood and sheathed by FRP has been determined along the coast of Kerala, India, and chemical emissions have been estimated when boats are burned as a means of disposal. A total of 292 abandoned boats were observed across eight coastal transects constructed around selected landing centres, with abandonment ranging from 13 to 48 per km (average = 29 km−1). This results in the generation …

Ideal Models Of Good Inpatient Care For Adults With Intellectual Disability: Lessons From England, Lisa Burrows, Georgia Page, Elena Plugaru, Bridie Kent, Mahesh Odiyoor, Sujeet Jaydeokar, Jonathan Williams, Kevin Elliot, Richard Laugharne, Rohit Shankar

School of Nursing and Midwifery

Background: In recent years, a significant proportion of inpatient facilities for people with intellectual disabilities and/or autism has been de-commissioned in England, This has resulted in individuals with intellectual disabilities being sent to distant hospitals far away from their families and carers leading to challenges in follow-up, community care and interventions. The impact of de-institutionalisation, has often caused patient trauma, family distress and subsequent discharge difficulties. Not every individual with intellectual disabilities and/or autism requires inpatient care but inpatient care when needed has to be local, adequate and appropriate. Aims: To evaluate current evidence of utility of inpatient models for …

Incorporating Usability Evaluation Into Iterative Development Of An Online Platform To Support Research Participation In Parkinson’S Disease: A Mixed Methods Protocol, Rebecca Chapman, Marie Louise Zeissler, Edward Meinert, Stephen Mullin, S Whipps, J Whipps, K Hockey, P Hockey, Camille B. Carroll

School of Nursing and Midwifery

Abstract Introduction Many people with Parkinson’s (PwP) are not given the opportunity or do not have adequate access to participate in clinical research. To address this, we have codeveloped with users an online platform that connects PwP to clinical studies in their local area. It enables site staff to communicate with potential participants and aims to increase the participation of the Parkinson’s community in research. This protocol outlines the mixed methods study protocol for the usability testing of the platform. Methods and analysis We will seek user input to finalise the platform’s design, which will then be deployed in a …

Learning Developers As Writers: The Four Tendencies Framework To Get Writing, Alicja Syska, Carina Buckley

School of Law, Humanities and Social Sciences

Although writing is a key element of scholarly activity, Learning Development positioning within the third space means that Learning Developers expectations for writing may be internal as much as external, or a combination of the two, or neither. All too often, the lack of time is cited as a reason to not write, yet developing strategies to overcome this particular barrier does not give the whole story. Rather, it is necessary to understand our relationship with writing, our needs and proclivities, and also our inhibitions. This chapter presents a framework for understanding our writing tendencies, so we can then identify …

The Effect Of Government Support On Bureaucracy, Covid-19 Resilience And Export Intensity: Evidence From North Africa, A-Ke Onjewu, F Olan, Rb-B-I Nyuur, S Paul, Htt Nguyen

Plymouth Business School

No abstract provided.

Natural Resource Curse: A Literature Survey And Comparative Assessment Of Regional Groupings Of Oil-Rich Countries, Marwan Alssadek, James Benhin

Plymouth Business School

This paper provides an extensive review of the rapidly growing literature on the resource curse phenomenon, whereby natural resources-rich countries experience lower levels of economic growth and development than countries with fewer natural resources. The various theoretical explanations for the phenomenon, alongside a survey of the empirical literature, are critically discussed. Generally, the literature results are found to be mixed and no consensus is reached. This might be attributed to different time periods, data used, proxy for the natural resource variables selected and the estimation approach employed. The practical part of this paper applies a descriptive analysis to compare economic …

Spatial Robustness: Double-Design And The Democratization Of Space, An Exploration Of Designing For Multiple Uses, Michael Cassidy

School of Art, Design and Architecture Theses

Spatial Robustness: Double-design And The Democratization Of Space, An Exploration Of Designing For Multiple Uses by Michael Warren Arkinstall Cassidy Differing attitudes to the expected life and value of architecture characterize the sustainability debate, yet space itself is rarely mentioned. The buildings for which architecture is responsible comprise both space and materials. While it is taken for granted that some existing buildings can be reused productively, this cultural phenomenon has not influenced the design of the new stock. While content to revere old buildings, the qualities that make them valued have not influenced design principles for new projects. Should new …

Reframing Museum Epistemology For The Information Age: A Discursive Design Approach To Revealing Complexity, Coral Manton

School of Art, Design and Architecture Theses

This practice-based research inquiry examines the impact of an epistemic shift, brought about by the dawning of the information age and advances in networked communication technologies, on physical knowledge institutions - focusing on museums. The research charts adapting knowledge schemas used in museum knowledge organisation and discusses the potential for a new knowledge schema, the network, to establish a new epistemology for museums that reflects contemporary hyperlinked and networked knowledge. The research investigates the potential for networked and shared virtual reality spaces to reveal new ‘knowledge monuments’ reflecting the epistemic values of the network society and the space of flows. …

A Framework For Syncretic Pluriversal Narrative: Somaesthetics And Consciousness In Thai Design Education, Tommaso Maggio

School of Art, Design and Architecture Theses

The investigation began by examining the diverse conceptions of creativity in the Western and Eastern hemispheres, specifically focusing on ‘Ex nihilo’ and ‘In situ’ (Ames) and how it is applied to creative education. The studies delved into the early modern art and design schools in Western countries, such as the German Bauhaus Art School (1919-33) and the Russian Vkhutemas Institute (1920-30), to gain a comprehensive understanding of how these experimental educational institutions influenced and continue to influence the contemporary global design education agenda. The thesis poses questions about how these approaches have been adapted within significantly different cultural contexts. The …

Performance Writing, Objects And Millennial Precarity: A Co-Authored Par Exploration Between Friends, Chris Green

School of Art, Design and Architecture Theses

This practice-as-research project uses performance writing to understand, illustrate and work through aspects of millennial experience, with a specific interest in precarious housing and labour. For us, experiencing precarity means that fundamental aspects of what is required to experience what Lauren Berlant calls ‘a good life’ (including secure working contracts, renters’ rights, access to leisure time) are not being met. This leads to a feeling of ‘living on the edge’ (Ahmed, 2017: 238), which in turn prevents us from being able to imagine alternatives. This performance writing takes the form of scores, instructions, maps, walking, knitting, zines, and audio recordings. …

The Postnatural Animal In Contemporary Art, Paul Finnegan

School of Art, Design and Architecture Theses

The thesis uses art practice as a research method to propose novel characterisations of animal life. These characterisations aim to challenge an organicist image of non-human animals. The thesis considers animal bodies and behaviours as subject to aesthetic judgments that are underpinned by deeper ontological and epistemological commitments as to relations between nature and society, in which to be categorised as the former entails a series of privations in relation to the latter – the absence of freedom, subjectivity and creativity. Scholarly research on the history of the perception and conception of animal life within modernity, and subsequent challenges made …

The Importance Of Multimodal Play And Storytelling In Medtech For Children: A Case Study Of Co-Designing A Mixed Realities Play Kit To Prepare 4 To 10-Year-Olds For An Mri Scan, D Yamada-Rice, S Love, J Thompson, S Thompson, H Mcquillian

School of Art, Design and Architecture

This article examines the research and development of a mixed realities play-kit to prepare children for an MRI scan to be undertaken without the need for a General Anaesthetic. The kit uses three different types of play; augmented, virtual reality and physical to help children become familiar with the look of an MRI scanner, the noises it makes, the role of the radiographer, what to expect when they go to hospital and to practise staying still. We reflect on the initial multimodal research methods that were used to bring children into the first stages of the design and development process. …

An Accumulation Of Care: Affect In The Role Of The Contemporary Curator, Sara-Jayne Parsons

School of Art, Design and Architecture Theses

This research portfolio investigates an affective approach to contemporary curatorial practice that is shaped by an accumulation of care. By retracing my working methods and noticing small shifts or interruptions, I reveal transformative, incremental changes in my work as a curator. I introduce curatorial practice where care is described as the physical and intellectual concern for objects in a museum, and consider traditional narratives ascribed to the role of a curator. I then propose an expanded understanding of care in curatorial practice that goes beyond stewardship to encompass engagement, empathy and allyship. Adopting a posthumanist methodological strategy which negotiates subjectivity …

Humanity Undone, A Practice Led Enquiry Into Self-Injury, Karen Abadie

School of Art, Design and Architecture Theses

This thesis enquires into my lived experience of self-injury (cutting my own skin), asking to what extent can moving image, sound and performance in the context of art installation reveal an understanding of the processes of self-injury. I employ an embodied onto-epistemological methodology that blends artistic enquiry with active engagement with phenomenological and new materialist feminist theory. This investigation reveals a dynamic yet subtle relationship between the body-as-object and the body-as- subject, as initially described by Husserl as Leib and Körper (1990). I use 16mm film and performance in a haptic immersive installation environment to articulate these dynamic subtleties. Merleau-Ponty …