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Intensive Versus Standard Blood Pressure Control After Endovascular Thrombectomy In Acute Ischemic Stroke: A Meta‐Analysis Of Randomized Controlled Trials, Tallal Mushtaq Hashmi, Mushood Ahmed, Hadiah Ashraf, Muhammad Shakir, Ibrahim Ahmad Bhatti, Faizan Ahmed, Ahmad Alareed, Ali Hasan, Gregg C. Fonarow, Ameer E. Hassan

School of Medicine Publications

Background: The optimal strategy for blood pressure management following mechanical thrombectomy for acute ischemic stroke due to large vessel occlusion remains a subject of ongoing research.

Methods: We comprehensively searched PubMed, Embase, and the Cochrane Library from inception to June 20, 2025. Randomized controlled trials comparing intensive versus standard blood pressure control following mechanical thrombectomy for acute ischemic stroke were included. The primary outcomes were excellent functional outcome (modified Rankin Scale score 0-1 at 90 days) and good functional outcome (modified Rankin Scale score 0-2 at 90 days). Pooled odds ratios (ORs) with 95% CIs were calculated using a random-effects …

Out-Of-Pocket Costs And Antihypertensive Medication Use Among Veterans: A Natural Experiment, Alexander R. Zheutlin, Alexander Chaitoff, Daniel Addo, Joshua A. Jacobs, Catherine G. Derington, Eric L. Stulberg, Peter A. Glynn, Bernardo Modenesi, Jordana B. Cohen, Adam P. Bress

Department of Neurology Faculty Papers

BACKGROUND: Blood pressure (BP) control remains suboptimal in the United States despite available low-cost antihypertensive medications. Even small out-of-pocket medication costs may contribute to adherence. We determined whether $0 versus >$0 out-of-pocket costs for antihypertensive medications is associated with differences in adherence, discontinuation, BP control, and cardiovascular outcomes.

METHODS: We included veterans with newly diagnosed hypertension who initiated antihypertensive medication in the Veterans Health Administration from 2004 to 2022. A fuzzy regression discontinuity design with 2-stage residual inclusion leveraged differences in medication copay policy at a 50% service-connected disability threshold (≥50% service-connected disability: $0 out-of-pocket cost versus < 50%: $8 monthly cost). Outcomes included 1-year medication nonadherence (proportion of days covered < 80%), 1-year medication discontinuation (no medication in the final 90 days of the study year), 1-year BP control (systolic BP/diastolic BP < 140/90 mm Hg and < 130/80 mm Hg) and cardiovascular disease events (myocardial infarction, coronary revascularization, peripheral artery disease, or stroke).

RESULTS: Among 417 …

Cover And Contents

Turkish Journal of Biology

No abstract provided.

Unusual Rna Polymerase Ii Patterns In Meiotic Prophase I In Nannospalax Xanthodon: Insights Into Chromatin, Telomeres, And Sex Chromosomes, Sergey N. Matveevsky, Ferhat Matur, Faruk Çolak, Andrei Kandaurov, Mustafa Sözen, Svetlana V. Pavlova, Oxana Kolomiets

Turkish Journal of Biology

Background: Meiotic transcription is a highly regulated process involving stage-specific chromatin remodeling and dynamic RNA polymerase II (RNAPII) activity. Nevertheless, our current understanding is largely based on classical model organisms, while many nonmodel mammals remain unexplored. This study investigates the transcriptional dynamics and chromatin features during meiotic prophase I in Nannospalax xanthodon, a subterranean blind mole rat species with extensive intraspecific karyotype variation.Materials and methods: Using immunofluorescence, we analyzed synapsis and transcriptional activity in spermatocyte nuclei of two geographically distant N. xanthodon males, detecting SYCP3, CREST, γH2AFX, and phosphorylated RNAPII (Ser5, Ser2). Telomereassociated proteins RAP1 and TERT were also examined …

Protective Effect Of Pinocembrin On Zearalenone-Induced Hepatotoxicity Via Pi3k/Akt And Nrf2 Signaling In Albino Mice, Sujatha Tejavat

Turkish Journal of Biology

Background/aim: Zearalenone (ZEA) is a Fusarium-derived mycotoxin that frequently contaminates food and feed and induces hepatotoxicity in humans and animals through oxidative stress and inflammation. Pinocembrin (PCM), a naturally occurring flavonoid, has potent antioxidant and antiinflammatory properties. This study investigated the hepatoprotective effects of PCM against ZEAinduced liver injury in albino mice, with a focus on the nuclear factor erythroid 2–related factor 2 (NRF2) and phosphoinositide 3-kinase/protein kinase B (PI3K/Akt) signaling pathways. Materials and methods: Twenty-four albino male mice were allocated into four groups: (1) control (vehicle 0.05% dimethyl sulfoxide), (2) ZEA-treated (40 mg/kg body weight), (3) PCM-treated (50 mg/kg …

Single-Walled Carbon Nanotube-Mediated Plasmid Dna Delivery In The Model Monocot Brachypodium Distachyon, Kaya İşleyen Bi̇lge, Bahar Soğutmaz Özdemi̇r

Turkish Journal of Biology

Background/aim: Plant genetic engineering is a valuable approach for improving stress tolerance, crop productivity, and quality traits. However, its progress is limited by the drawbacks of traditional transformation methods. Commonly used techniques, such as Agrobacterium-mediated transformation and biolistics, are restricted by genotype dependency, lengthy tissue culture steps, and low efficiency, particularly in monocot species. Therefore, the development of alternative gene delivery strategies remains an ongoing research focus in plant biotechnology. Nanoparticle-based delivery systems have recently gained attention due to their physiochemical properties, biocompatibility, and potential for alternative gene delivery approaches in plant systems.Materials and methods: We investigated the use of …

Modulating Microtubule Stability Via Α-Tubulin Acetylation Partially Restores Golgi Fragmentation In Spinal Muscular Atrophy, Peli̇n Zobaroğlu Özer, Memet Gözüböyük, Özge Çeti̇n, Niko Hensel, Güzi̇n Emecen, Adam Malik, Melissa Bowerman, Peter Claus, Hayat Erdem Yurter, Gamze Bora Akoğlu

Turkish Journal of Biology

Background/aim: Spinal muscular atrophy (SMA) is a neurodegenerative disease caused by the loss of survival of motor neuron (SMN) protein. SMN deficiency leads to perturbations of the cytoskeleton, including microtubules, which are mainly involved in motilityrelated cellular processes. However, the molecular mechanisms of microtubule dysregulation in SMA remain elusive. Alpha (α)-tubulin is a structural component of microtubules, and its posttranslational modifications affect microtubule dynamics. Here, we aimed to investigate α-tubulin acetylation and related molecular mechanisms in SMA. Materials and methods: Two different SMA mouse models, the Drosophila melanogaster model and patient-derived fibroblasts, were used in the study. Western blot and …

Combinatorial Effect Of Epirubicin And 5-Fluorouracil In The Treatment Of Temozolomide-Resistant Glioblastoma Cells, Mehrsa Bayat, Muhli̇s Akman, Türker Kiliç, Ti̇muçi̇n Avşar

Turkish Journal of Biology

Background: Glioblastoma (GBM) is a highly aggressive form of brain tumor characterized by rapid proliferation and invasiveness. It is associated with a poor prognosis due to acquired resistance to temozolomide (TMZ). In this study, we investigated whether a combination of epirubicin, 5-fluorouracil (5-FU), and TMZ could improve TMZ sensitivity in resistant GBM cells and help overcome resistance.Materials and methods: TMZ resistance was established in the U87MG cell line. The MTT assay was used to measure cell viability. Reactive oxygen species (ROS) and apoptosis were measured using flow cytometry. RNA-seq was used to evaluate genomic changes based on treatment with drugs …

What's The Scoop On Life In New Hampshire? Youth Perspectives On New Hampshire As A Place To Live, Learn, And Work After High School, Elliot Ng, Jayson Seaman, Cindy L. Hartman, Andrew D. Coppens, Kate Moscouver, Hannah Falcone

Carsey Publications

To support its long-term economic vitality, New Hampshire must cultivate and retain its young talent. This brief analyzes the perspectives of New Hampshire youth and proposes actionable strategies that encourage them to build their futures in the state. While a majority of New Hampshire youth leave the state after high school, retention opportunities lie in leveraging what youth already love about the Granite State: Its natural environment, abundant outdoor amenities, and safe communities. By leveraging these assets and complementary policies such as expanding career-connected learning, promoting the abundance of in-state opportunities, and developing centralized social spaces, New Hampshire can create …

Designing Next-Generation Cardiometabolic Outcome Trials For Obesity Medicines, Elke Platz, Alexander Peikert, Biykem Bozkurt, Bart Van Der Schueren, Javed Butler, Ildiko Lingvay, Darren K Mcguire, Faiez Zannad, Naveed Sattar

Faculty, Staff and Students Publications

The prevalence of obesity has reached pandemic proportions and is having enormous public health effects. Obesity increases the risk of type 2 diabetes, hypertension, chronic kidney disease, and cardiovascular (CV) disease including coronary artery disease, heart failure, atrial fibrillation, and stroke. Although initial randomized clinical trials of weight-loss strategies through diet and exercise or early medical therapies did not lead to improved CV outcomes, more recent trials using glucagon-like peptide-1 (GLP-1) receptor agonists in individuals with obesity have demonstrated CV benefits. At present, there are multiple cardiovascular outcome trials (CVOTs) of novel GLP-1 receptor agonists and investigational products targeting multiple …

Prodromal Lewy Body Disorder Features In Rem Sleep Behavior Disorder With Biomarker-Defined Synucleinopathy, Daniel Weintraub, Michele K York, Roseanne Dobkin, Anuprita R Nair, Ryan Kurth, David-Erick Lafontant, Chelsea Caspell-Garcia, Roy N Alcalay, Ethan G Brown, Lana M Chahine, Christopher Coffey, Tatiana Foroud, Douglas Galasko, Karl Kieburtz, Kenneth Marek, Kalpana Merchant, Brit Mollenhauer, Kathleen L Poston, Andrew Siderowf, Cristina Simonet, Tanya Simuni, Caroline M Tanner, Thomas F Tropea, Aleksandar Videnovic, Parkinson's Progression Markers Initiative

Faculty, Staff and Students Publications

Objective: Isolated rapid eye movement sleep behavior disorder (iRBD) is a prodromal state for Lewy body disorders and exhibits biological heterogeneity that may influence clinical expression and progression. We examined clinical features in individuals with iRBD and biomarker-defined synucleinopathy.

Methods: Parkinson's Progression Markers Initiative (PPMI) is a longitudinal, multi-center observational study. Participants included polysomnogram (PSG)-confirmed iRBD individuals who were cerebrospinal fluid (CSF) α-synuclein seed amplification assay positive with no clinical diagnosis of Parkinson's disease or dementia with Lewy bodies, along with robust healthy controls (HCs). Clinical and biological features of prodromal PD and DLB, including mild cognitive impairment (MCI), subthreshold …

Obstructive Sleep Apnea Treatment Modifies The Effectiveness Of Catheter Ablation For Atrial Fibrillation: Post Hoc Analysis Of The Cabana Trial, Matthew W Segar, Kaleb D Lambeth, Brett Doliner, Joshua R Hirsch, Abdi Rasekh, Mehdi Razavi

Faculty, Staff and Students Publications

No abstract provided.

The Impact Paradox: Mixed-Methods Evaluation Of National Institute Of Health And Care Research Funding For Intellectual Disability Research In The Uk, Rohit Shankar, Richard Laugharne, Sarah Lennard, Samuel Tromans, Nathan Goddard, Madeline Dale, Ruth Bishop, Nathan Johnson, Maxine Hough

Peninsula Medical School

BackgroundPeople with intellectual disability experience substantialhealth inequities, including higher multimorbidity, increasedhealthcare utilisation and markedly reduced life expectancy.High-quality research is essential to address these disparities.The National Institute for Health and Care Research (NIHR)funded Research Delivery Network provides the infrastructure/expertise/support needed to deliver NIHR-funded studies, andsupports studies funded by a non-commercial/industry partner. However, the effectiveness of NIHR-funded studies versusthose supported in driving impactful intellectual disabilityresearch remains unclear.AimsTo evaluate and compare the outcomes of NIHR-funded andsupported intellectual disability research.MethodAll NIHR studies (funded/supported) relating to intellectualdisability (2010–2020) were identified through systematicregister searches. Primary outcomes included publicationrates and impact on local, national and international clinicalguidelines. …

The Diamond Minutes: Rethinking The Earliest Link Of The Trauma Chain Of Survival, Guglielmo Imbriaco, Sonia D’Arrigo, Francesco Limonti, Tim Nutbeam, Alberto Cucino

Peninsula Medical School

Matters arising.Trauma remains one of the leading causes of death worldwide, particularly among children, adolescents, and working-age adults. Despite major advances in trauma system and hospital-based care, a significant proportion of fatalities occur in the prehospital setting, often within minutes and before arrival of emergency medical services (EMS) [1]. Observational analyses consistently suggest that between one quarter and nearly half of trauma-related deaths occur before hospital arrival [2]. A recent prospective multicentre study involving over 1,000 patients with haemorrhagic shock demonstrated that, despite improvements in trauma centre capabilities, including whole blood resuscitation, hybrid operating rooms, and endovascular haemorrhage control, the …

Sowing Imbalance From The Start: Power, Role Socialization, And Graduate Assistants In Ncaa Division I Power Four Athletic Departments, Kaitlin Pericak, Daniel Springer, Brittany Washington, Rachel Silva

Journal of Issues in Intercollegiate Athletics

Graduate assistantships represent early entry points into intercollegiate athletics and serve as critical sites of professional socialization. Guided by Mead’s (1934) role theory and Foucault’s (1975/1977) concept of power, this study examined how graduate assistants (GAs) negotiated their dual roles as students and employees within Division I Power Four athletic departments. Semi-structured interviews with 10 current GAs revealed how organizational expectations normalized overwork, positioned the master’s degree as a compulsory credential, and sowed imbalance that shaped participants’ identities and well-being. Findings demonstrate how GAs internalized structured constraints and reproduced organizational norms, framing overwork as a necessary rite of passage. These …

Creating Strategy-Focused Universities Using The Balanced Scorecard And Accreditation Framework, Mohammed Fayazuddin, Balaji N, Sankar Ganesh

Journal of Global Management Research

The Balanced Scorecard (BSC) is a versatile framework for performance measurement and strategic management. It has been widely successful in helping businesses and institutes of higher education (IHE) implement strategies and achieve their mission and vision by maintaining a balance between financial and non-financial metrics. Globally, numerous universities have adopted the BSC to enhance quality and address the needs of stakeholders effectively.This study explores the adoption of the Balanced Scorecard in universities, examining its advantages, prerequisites, and challenges. It also establishes a link between the four perspectives of the BSC—financial, customer, internal process, and learning and growth—and the thirty-four key …

Foreign Pedagogy In Education: Theoretical Foundations, Cross-Cultural Dynamics, And Implications For Global Learning, Chitra Venugopal, Prabhakar Rontala Subramaniam

Journal of Global Management Research

This conceptual paper examines foreign pedagogy as a critical lens for understanding how teaching philosophies, instructional strategies, and educational values travel across cultural and national boundaries. Drawing on comparative education, sociocultural theory, and postcolonial scholarship, the paper investigates the processes by which pedagogical models are borrowed, adapted, or imposed between educational systems. It argues that foreign pedagogy is not a neutral transfer of knowledge but a deeply ideological practice shaped by power, cultural epistemology, and institutional context. The paper identifies five central themes: the philosophical roots of major global pedagogical traditions, the mechanisms of pedagogical transfer and borrowing, the tensions …

Green Corporate Responsibility And Sustainable Human Resource Management (Hrm) Functions, Sundara Boopathi R, Shanmugam Sundararajan

Journal of Global Management Research

In order to encourage employee sustainability behavior and achieve long-term organizational success, Green Corporate Responsibility and Sustainable Human Resource Management (HRM) departments place a strong emphasis on incorporating environmental principles into HR processes. Within the context of Green Corporate Social Responsibility (GCSR), this study investigates how Sustainable Human Resource Management (Green HRM) functions affect Organizational Sustainability through the mediating roles of Pro-environmental Behavior (PEB) and Pro-environmental Psychological Climate (PEPC). based on the Resource-Based View (RBV), Social Exchange Theory (SET), and Ability-Motivation-Opportunity (AMO) theory. By incorporating six essentials Green HRM practices-green hiring and selection, green training and development, green performance evaluation, …

Identifying Skill Gaps And Upskilling Priorities For C-Level Executives Using The Analytic Hierarchy Process (Ahp) Analysis, Mohamed Riyazhkhan, Mohsin Aziz, Krishna Murthy, Abdul Azeez K M, George Anthony Fernando

Journal of Global Management Research

C-level executives, or chief-level executives, play a significant role in corporate development, and their roles and responsibilities are essential for sustaining organizational effectiveness in an increasingly competitive business environment. They also constitute a fundamental component of organizational management systems (Julie & Emory, 2006). In this research, data were collected exclusively from C-level or C-suite executives (CEO, CFO, COO, and CHRO) from leading corporations in Oman and India. This study investigates three representative cases related to managerial functions across various corporate organizations. The first case examines the job descriptions associated with C-level executives, the second case explores the identification of skill …

A Critical Perspective On Artificial Intelligence's Energy Footprint And Future Research Questions For Accounting And Business Research, Dr Mansi Mansi, Rakesh Pandey

Journal of Global Management Research

No abstract provided.

Feedback Menus: Expanding Student Choice In Response To Writing, Andrew Testa

Journal of Response to Writing

This Teaching Tip introduces the Feedback Menu, a flexible protocol designed to promote student agency and feedback literacy in writing instruction. By allowing students to select the focus and mode of feedback they receive, the Menu helps tailor response to individual learning needs and supports meaningful revision at any stage of the composition process. The protocol is adaptable for use in first-year composition, professional writing, multilingual, and upper-division courses, in both face-to-face and online formats. Concrete implementation steps, sample menu items, and considerations for different teaching contexts are provided.

More Than Treating Errors: Bridging The Gaps And Expanding The Agenda For Scholarship On Teacher Written Feedback For L2 Writers, Lynn Goldstein, Robert Kohls

Journal of Response to Writing

Teacher written feedback is a central area of L2 scholarship and writing teacher education yet considerable research has focused on written corrective feedback (WCF) with considerably less attention paid to discourse-level (DLF) teacher written feedback. Our article identifies the gaps in the current teacher written feedback scholarship, explains why these gaps are problematic, and provides detailed recommendations for an agenda that examines teacher DLF and students’ use of this feedback. Our goal is to encourage scholars to explore new avenues of research that better take into account what writing “is” and “does” as well as take into account the linguistically …

Composing In Relation: Rethinking Multimodal Feedback As Rhetorical Design, Angela Laflen

Journal of Response to Writing

This qualitative study investigates how writing instructors compose feedback in multimodal digital environments, focusing on the rhetorical and relational dimensions of their design choices. Drawing on social semiotics and multimodal composition theory, the study analyzes feedback artifacts, instructor interviews, and student surveys from six first-year writing courses. Findings reveal that instructors engage in complex feedback design work across communication modes, often without formal training or shared frameworks. Instructors tended to default to text-based habits shaped by genre memory but adapted their strategies in response to communicative breakdowns and student needs. The study identifies three core themes: reliance on print-era conventions, …

Examining Automated Writing Evaluation Error Coverage In Relation To Uptake And Retention, Mohaddeseh Mehrzad, Mohammad Rahimi, Stephanie Link

Journal of Response to Writing

Despite the current widespread use of Automated Writing Evaluation (AWE) feedback, many issues regarding its efficacy still remain unresolved. Recent studies mainly focus on correctly detected errors with a lack of attention on the comprehensiveness of error detection, or error coverage. Error coverage is interesting because little is known about the capacity of AWE systems to fully detect common second language (L2) errors. It is also important to investigate the potential effect of such capacity on student uptake and retention, which are important constructs in fostering L2 writing development. To this end, the present study compared teacher feedback and AWE …

Navigating Feedback In Collaborative Writing: The Impact Of Student Backgrounds And Expectations On Transitions To New Academic And Social Spaces, Lindsey Gruber, María Fernández–Agüero

Journal of Response to Writing

This article examines how international students navigate feedback from a supervisor while working on a group writing project in a diverse English medium of instruction (EMI) bachelor’s program at a public university in Denmark, where no formalized writing or language support resources are offered in the students’ first year of instruction. Data were collected in qualitative, semi-structured interviews with 11 students who were identified through a survey of a first-year bachelor of arts cohort. Results from the survey showed that despite using a supervision model of education, few students perceived changes in feedback compared to their secondary school experiences, and …

Editors' Introduction, Betsy Gilliland, Lucie Moussu

Journal of Response to Writing

No abstract provided.

Book Review Of Suburban Refugees: Class And Resistance In Little Saigon, Phoebe T. Pham

Journal of Southeast Asian American Education and Advancement

In Suburban Refugees: Class and Resistance in Little Saigon, Jennifer Huynh challenges the common view that refugee resettlement follows a straightforward path toward assimilation, stability, and upward mobility. Focusing on Vietnamese refugees in Little Saigon, Orange County, California, Huynh examines how refugees navigate displacement, housing insecurity, and political exclusion in suburban spaces often idealized as homogenous and prosperous. Drawing on extensive data, the book presents suburban resettlement as a prolonged process shaped by structural forces and community resistance. Huynh situates her analysis within growing suburban inequality and enduring racialized policies that limit refugee opportunities long after formal resettlement. Her …

A Phenomenological Study On The Connection Between Perceived Funding And Hbcu Athletic Staff Self-Efficacy, Ashley Keys

Liberty University Research Week

No abstract provided.

Finding One’S Calling: Vocational Identity, Engagement, And Career Satisfaction Among Golf Industry Professionals, Aaron Katzenberger

Liberty University Research Week

The golf and hospitality industry operates in a high-stress, demanding environment that frequently leads to decreased employee engagement, poor work-life balance, and industry burnout. A significant gap exists in current literature regarding how these professionals can successfully identify and align their daily operations with their true vocational calling. To address this gap, this proposed applied research framework explores the intersection of vocational identity, engagement, and career satisfaction among golf industry professionals. Utilizing a qualitative single-case study methodology, this research proposes conducting semi-structured interviews with active PGA members. The study analyzes key constructs, including self-esteem, job satisfaction, quality of life, and …

Music Enhances Theta Brainwave Activity Regardless Of Tuning Frequency, Robert Somerville, Davis Raz, Jettson Yarborough, Luc-Shalom Kouame

Liberty University Research Week

No abstract provided.