Digital Commons Network^™

Gamma Delta T Cells In Acute Myeloid Leukemia: Biology And Emerging Therapeutic Strategies, Adishwar Rao, Akriti Agrawal, Gautam Borthakur, Venkata Lokesh Battula, Abhishek Maiti

Faculty, Staff and Student Publications

γδ T cells play an important role in disease control in acute myeloid leukemia (AML) and have become an emerging area of therapeutic interest. These cells represent a minor population of T lymphocytes with intrinsic abilities to recognize antigens in a major histocompatibility complex-independent manner and functionally straddle the innate and adaptive immunity interface. AML shows high expression of phosphoantigens and UL-16 binding proteins that activate the Vδ2 and Vδ1 subtypes of γδ T cells, respectively, leading to γδ T cell-mediated cytotoxicity. Insights from murine models and clinical data in humans show improved overall survival, leukemia-free survival, reduced risk of …

Differential Upregulation Of Th1/Th17-Associated Proteins And Pd-L1 In Granulomatous Mycosis Fungoides, Mario L Marques-Piubelli, Jesus Navarrete, Debora A Ledesma, Courtney W Hudgens, Rossana N Lazcano, Ali Alani, Auris Huen, Madeleine Duvic, Priyadharsini Nagarajan, Phyu P Aung, Ignacio I Wistuba, Jonathan L Curry, Roberto N Miranda, Carlos A Torres-Cabala

Faculty, Staff and Student Publications

Granulomatous Mycosis Fungoides (GMF) is a rare form of mycosis fungoides (MF) characterized by a granulomatous infiltrate associated with the neoplastic lymphoid population and is considered to have a worse prognosis compared with regular MF. The upregulation of the T helper (Th) axis, especially Th17, plays an important role in the pathogenesis of several inflammatory/infectious granulomatous cutaneous diseases, but its role in GMF is still not elucidated to date. In this study, we evaluated the immunohistochemical expression of Th1 (Tbet), Th2 (GATA-3), Th17 (RORγT), T regulatory (Foxp3), and immune checkpoint (IC) (PD-1 and PD-L1) markers in a cohort of patients …

Mortality After Major Cardiovascular Events In Survivors Of Childhood Cancer, Wendy Bottinor, Cindy Im, David R Doody, Saro H Armenian, Alexander Arynchyn, Borah Hong, Rebecca M Howell, David R Jacobs, Kirsten K Ness, Kevin C Oeffinger, Alexander P Reiner, Gregory T Armstrong, Yutaka Yasui, Eric J Chow

Faculty, Staff and Student Publications

Background: Adult survivors of childhood cancer are at risk for cardiovascular events.

Objectives: In this study, we sought to determine the risk for mortality after a major cardiovascular event among childhood cancer survivors compared with noncancer populations.

Methods: All-cause and cardiovascular cause-specific mortality risks after heart failure (HF), coronary artery disease (CAD), or stroke were compared among survivors and siblings in the Childhood Cancer Survivor Study (CCSS) and participants in the Coronary Artery Risk Development in Young Adults (CARDIA) study. Cox proportional hazard regression models were used to estimate HRs and 95% CIs between groups, adjusted for demographic and clinical …

Front Matter

West Virginia Law Review

No abstract provided.

Relative Periodicity Of Empirical Audio Samples With Application To Dissonance Perception, Linden Faye, Spencer Kuhn, Anil Venkatesh

LASER Journal

The concept of dissonance in music perception has been variously associated with the physical concepts of roughness, instability, and tension by appealing to a subjective cross-sensory analogy. For all the subjectivity around the term, it is noteworthy that non-musical test subjects in clinical experiments have produced remarkably consistent rank-orderings of musical sounds, according to the perceived dissonance of those sounds. Further studies in psychology, neuroscience, and mathematics show that consonance perception appears to be influenced not only by convention and culture but by the psychoacoustics of sound perception, likely by some combination of the Helmholtz theory of roughness and the …

Interviews In Global Catholic Studies: Richard Wood, Mathew N. Schmalz, Richard Wood

Journal of Global Catholicism

No abstract provided.

Interviews In Global Catholic Studies: Matthew Eggemeier And Peter Fritz, Mathew N. Schmalz, Matthew Eggemeier, Peter Joseph Fritz

Journal of Global Catholicism

No abstract provided.

Interviews In Global Catholic Studies: Mary Dunn, Mathew N. Schmalz, Mary Dunn

Journal of Global Catholicism

No abstract provided.

The Double Bond Of Catholic Abolition: Christianity, Chattel Slavery, And Racial Capitalism, Elayne Oliphant

Journal of Global Catholicism

The reign of the first Pope to originate in the former colonies of the modern Euro-Christian empires calls us into awareness of the layers of interconnection between the Roman Catholic Church and the long “wake” (Sharpe 2016) of 1492. As anthropologists, I argue, our studies of Catholic practices must be informed by a detailed awareness of this history. I offer a broad historical view of how the Roman Catholic Church participated and, at times, led the way in initiating the trans-Atlantic system of Black chattel slavery and colonial expropriation in Euro-Christian Empires. As a scholar of Catholicism in France, I …

The Missionary And The Pea: An Anthropological Study Of The French Mep Economy, Michel Chambon

Journal of Global Catholicism

This paper discusses how the French missionaries of the Missions Etrangères de Paris (MEP) are linking humans and material objects to support their religious agenda. Revisiting the long history of this organization in Hong Kong and Thailand, but also its distinct recruitment and assignment policies, I highlight how these Catholic missionaries rely on their French cultural background to interconnect people and goods. While theological principles and political pragmatism shape their functioning, I argue that their economy is distinctively rooted in the French notion of terroir –the taste of place— an embodied relation to land that acts as a cultural mechanism …

A Queer Chinese Pilgrimage: Encountering Catholic Life In Manila, George Wu Bayuga

Journal of Global Catholicism

Starting in the late 1990s, Chinese Catholic priests, sisters, and seminarians began journeying to the Philippines to undergo religious and spiritual formation. This paper documents this journey and characterizes it as a kind of queer pilgrimage. Recognizing the queer theoretical parallels between minoritized populations under hegemony and Catholic life under socialism, this paper calls for attention to the queer work of imagining futures that emerges through processes of movement, encounter, and reflexivity across new political and social spaces. Specifically, this paper highlights how state-religious relations under socialism can differentially shape how Chinese Catholics think of themselves, faith formation, and how …

From Canonical Law To Offshore Finance: Confessing To Priests And Bankers In Luxembourg, Samuel Weeks

Journal of Global Catholicism

In this article, I address two recurring tendencies that I heard during a recent period of research on banking secrecy in Luxembourg. First, my banker interviewees frequently mentioned personal transgressions for why many of their clients hide assets “offshore.” The wrongdoings my interlocutors cited included not only clients’ tax evasion, bankruptcy, and avoidance of liability – but also divorce, adultery, and the existence of out-of-wedlock children. Second, with a similar frequency, my interviewees drew parallels between the secrecy laws covering bankers and those afforded to other professionals in the country. Article 458 of Luxembourg’s Penal Code, dating from the nineteenth …

Optimizing Buying Strategies In Dominion, Nikolas A. Koutroulakis

Rose-Hulman Undergraduate Mathematics Journal

Dominion is a deck-building card game that simulates competing lords growing their kingdoms. Here we wish to optimize a strategy called Big Money by modeling the game as a Markov chain and utilizing the associated transition matrices to simulate the game. We provide additional analysis of a variation on this strategy known as Big Money Terminal Draw. Our results show that player's should prioritize buying provinces over improving their deck. Furthermore, we derive heuristics to guide a player's decision making for a Big Money Terminal Draw Deck. In particular, we show that buying a second Smithy is always more optimal …

University Of Johannesburg Institutional Repository Cybersecurity Output: 2015-2021 Interdisciplinary Study, Mancha J. Sekgololo

Journal of Cybersecurity Education, Research and Practice

This study examines cybersecurity awareness in universities by analyzing related research output across different disciplines at the University of Johannesburg. The diffusion of innovation theory is used in this study as a theoretical framework to explain how cybersecurity awareness diffuses across disciplines. The University of Johannesburg Institutional Repository database was the data source for this study. Variations in cybersecurity keyword searches and topic modeling techniques were used to identify the frequency and distribution of research output across different disciplines. The study reveals that cybersecurity awareness has diffused across various disciplines, including non-computer science disciplines such as business, accounting, and social …

Academic Citizenship As Civic Professionalism, Elizabeth A. Jach

New York Journal of Student Affairs

In this essay, I argue that academic citizenship needs to be focused on civic professionalism. Too often, individualism renders undue costs to the broader academic community. Looking to research in higher education on civic professionalism, I argue that its tenets, which focus on contributing to the community, can allow those of us in academia to realize for ourselves what we want for our students and future generations. I employ the lens of an ecological framework to illustrate the possibilities and priorities of viewing and implementing academic citizenship as civic professionalism.

A Canonical Transformation For The Anderson Lattice Hamiltonian With F–F Electron Coupling, Guang-Lin Zhao

Faculty Publications

In this work, a new canonical transformation for the Anderson lattice Hamiltonian with f–f electron coupling was developed, which was further used to identify a new Kondo lattice Hamiltonian. Different from the single impurity Kondo effect, the resulted new Kondo lattice Hamiltonian only includes the spin-flip scattering processes between conduction electrons and f-electrons, while the normal process of non-spin-flip scattering is absent in this Hamiltonian, under the second order approximation. The new Kondo lattice Hamiltonian may be used to study some anomalous physical properties in some Kondo lattice intermetallic compounds.

Adjustments To Social Work Practice During The Covid-19 Adjustments To Social Work Practice During The Covid-19 Pandemic In North Carolina: Effects On Burnout And Commitment Pandemic In North Carolina: Effects On Burnout And Commitment, Aaron Brown, Jayme E. Walters, Aubrey E. Jones, Lara Cates

Social Work Faculty Publications

Since the onset of the COVID-19 pandemic, the demand for social workers in the U.S. and abroad has increased. There is demand for more social workers in North Carolina due to ongoing and increasing mental health, substance use disorder, and child welfare needs. COVID-19 has taken a toll on the personal and professional lives of social workers, and research is needed to understand the pandemic’s effects on burnout and commitment among social workers. The present study sought to understand how the COVID-19 pandemic affected the personal and professional lives of social workers practicing in North Carolina and to determine how …

Social, Cultural, And Psychological Obstacles To Advancing Stem Agendas In Rural Texas, Brandon Bretl

Critical Proceedings of the STEM ED Conference (2023)

No abstract provided.

Food Security: At The Intersection Of Entrepreneurship, Engineering, And Agriculture, Noe Vargas Hernandez, Sylvia Robles, Joanne Rampersad-Ammons

Critical Proceedings of the STEM ED Conference (2023)

No abstract provided.

Mitosis Mystery!, Lluvia Garcia

Critical Proceedings of the STEM ED Conference (2023)

No abstract provided.

Intermittent-Aware Design Exploration Of Systolic Array Using Various Non-Volatile Memory: A Comparative Study, Nedasadat Taheri, Sepehr Tabrizchi, Arman Roohi

School of Computing: Faculty Publications

This paper conducts a comprehensive study on intermittent computing within IoT environments, emphasizing the interplay between different dataflows—row, weight, and output—and a variety of non-volatile memory technologies. We then delve into the architectural optimization of these systems using a spatial architecture, namely IDEA, with their processing elements efficiently arranged in a rhythmic pattern, providing enhanced performance in the presence of power failures. This exploration aims to highlight the diverse advantages and potential applications of each combination, offering a comparative perspective. In our findings, using IDEA for the row stationary dataflow with AlexNet on the CIFAR10 dataset, we observe a power …

Lanthorn, Vol. 58, No. 13, February 26, 2024, Grand Valley State University

Volume 58, August 7, 2023 - April 15, 2024

Lanthorn is Grand Valley State's student newspaper, published from 1968 to the present.

Inauthentic Inclusion: Exploring How Intention To Use Ai‐Generated Diverse Models Can Backfire, Sean Sands, Vlad Demsar, Carla Ferraro, Colin L. Campbell, Eli Cohen

School of Business: Faculty Scholarship

Rapid advances in AI technology have important implications for, and effects on, brands and advertisers. Increasingly, brands are creating digital models to showcase clothing and accessories in a similar way to human models, with AI used to customize various body types, ages, sizes, and skin tones. However, little is known about how the underrepresented consumers respond to a brand's intention to use AI-generated models to represent them. We explore this by conducting four studies. We find evidence that a brand's intention to use AI-generated (vs. human) models negatively affects brand attitude (study 1). We further investigate this effect using two …

The Utah Statesman, February 26, 2024, Utah State University

The Utah Statesman

Weekly student newspaper of Utah State University in Logan.

Roaring To Softly Whispering: X-Ray Emission After ∼3.7 Yr At The Location Of The Transient At2018cow And Implications For Accretion-Powered Scenarios, Giulia Migliori, R. Margutti, B. D. Metzger, R. Chornock, C. Vignali, D. Brethauer, Liliana E. Rivera Sandoval, J. S. Bright, T. Laskar, D. Milisavljevic

Physics & Astronomy Faculty Publications

We present the first deep X-ray observations of luminous fast blue optical transient (LFBOT) AT 2018cow at ∼3.7 yr since discovery, together with the reanalysis of the observation at δt ∼ 220 days. X-ray emission is significantly detected at a location consistent with AT 2018cow. The very soft X-ray spectrum and sustained luminosity are distinct from the spectral and temporal behavior of the LFBOT in the first ∼100 days and would possibly signal the emergence of a new emission component, although a robust association with AT 2018cow can only be claimed at δt ∼ 220 days, while at …

Vitamin E Biofortification: Enhancement Of Seed Tocopherol Concentrations By Altered Chlorophyll Metabolism, Ping Qin, Peng Chen, Yuanwei Zhou, Wei Zhang, Yunyun Zhang, Jingjing Xu, Lu Gan, Yingnan Liu, Jill Romer, Peter Dörmann, Edgar B. Cahoon, Chunyu Zhang

Department of Biochemistry: Faculty Publications

Homogentisate Phytyltransferase (HPT) catalyzes condensation of homogentisate (HGA) and phytyl diphosphate (PDP) to produce tocopherols, but can also synthesize tocotrienols using geranylgeranyl diphosphate (GGDP) in plants engineered for deregulated HGA synthesis. In contrast to prior tocotrienol biofortification efforts, engineering enhanced tocopherol concentrations in green oilseeds has proven more challenging due to the integral role of chlorophyll metabolism in supplying the PDP substrate. This study show that RNAi suppression of CHLSYN coupled with HPT overexpression increases tocopherol concentrations by >two-fold in Arabidopsis seeds. We obtained additional increases in seed tocopherol concentrations by engineering increased HGA production via overexpression of …

Evidence Review And Considerations For Use Of First Line Genome Sequencing To Diagnose Rare Genetic Disorders, Kristen M Wigby, Deanna Brockman, Gregory Costain, Caitlin Hale, Stacie L Taylor, John Belmont, David Bick, David Dimmock, Susan Fernbach, John Greally, Vaidehi Jobanputra, Shashikant Kulkarni, Elizabeth Spiteri, Ryan J Taft

Center for Medical Ethics and Health Policy Staff Publications

Early use of genome sequencing (GS) in the diagnostic odyssey can reduce suffering and improve care, but questions remain about which patient populations are most amenable to GS as a first-line diagnostic test. To address this, the Medical Genome Initiative conducted a literature review to identify appropriate clinical indications for GS. Studies published from January 2011 to August 2022 that reported on the diagnostic yield (DY) or clinical utility of GS were included. An exploratory meta-analysis using a random effects model evaluated DY based on cohort size and diagnosed cases per cohort. Seventy-one studies met inclusion criteria, comprising over 13,000 …

Impacts Of Marine Heatwaves On Subsurface Temperatures And Dissolved Oxygen In The Chesapeake Bay, Nathan P. Shunk, Piero L. F. Mazzini, Ryan K. Walter

Physics

Subsurface impacts associated with Marine Heatwaves (MHWs) in estuaries are not well understood, largely due to data scarcity. Using over three decades (1986–2021) of observations from several monitoring programs, this study investigates subsurface temperature and dissolved oxygen (DO) anomalies associated with surface MHWs in the Chesapeake Bay (CB). Seasonal variability in temperature anomalies followed a simple 1-D response to surface heating with downward heat transport and diffusion controlled by seasonally variable stratification and mixing. Two distinct temperature regimes were found: a thermally stratified spring-summer regime, when positive temperature anomalies were confined to the surface mixed layer (SML); and a homogeneous …

Invarianza De La Escala De Evaluación De Las Relaciones Intrafamiliares En Padres Con Y Sin Migración De Retorno Y Salud Mental [Invariance Of The Intrafamily Relations Evaluation Scale In Parents With And Without Return Migration And Mental Health], María Elena Rivera Heredia, Patricia Andrade Palos, Jaime Fuentes Balderrama, Luis H. Zayas

School of Social Work Faculty Publications

Se analizaron las propiedades psicométricas de la Escala de Evaluación de las Relaciones Intrafamiliares (ERI) en padres de familia que retornaron a México y que tienen hijos e hijas menores de edad nacidos en E.E.U.U., así como en padres mexicanos sin experiencia migratoria. Participaron189 padres (92 retornados y 97 sin migración). Se llevaron a cabo Análisis Factoriales Exploratorios y Confirmatorios para derivar una versión culturalmente invariante. Una vez obtenidas las evidencias de invarianza configural, métrica, escalar, estricta y estructural, se encontró mediante un modelo de ecuaciones estructurales que la unión y apoyo familiar se asocian con la sintomatología depresiva y …

Ecology And Management Of The Crapemyrtle Aphid (Hemiptera: Aphididae) On Crapemyrtle (Myrtales: Lythraceae) In The Southern United States, Caleb J. Wilson, Matthew A. Bertone

Entomology Faculty Publications

Crapemyrtle aphid [Sarucallis kahawaluokalani (Kirkaldy 1907)] (CMA) is an introduced pest of crapemyrtle (Lagerstroemia spp. L.), which is among the most common ornamental tree genera in the southern United States. Native to Southeast Asia, CMA has become established on 5 other continents. CMAs produce honeydew as they feed which supports sooty mold growth and can result in leaf defoliation on infested trees. CMAs tend to be most abundant in crapemyrtles planted in locations with extensive surrounding impervious surface cover. A large community of generalist natural enemies are found in close association with CMA, which suggests that CMAs may help conserve …