Digital Commons Network^™

Discontinuation Of Contact Precautions In Patients With Hospital-Acquired Mrsa And Vre Infections During The Covid-19 Pandemic: A Multi-Center Experience, Gillean Kelly, Marisa Hudson, Bridget Apple, Debora Bundage, Bradley Lembcke, Todd Lasco, Mayar Al Mohajer

Faculty, Staff and Students Publications

Variations in the literature support the benefit of contact precautions for methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE) infections in the hospital setting. During personal protective equipment shortages throughout the COVID-19 pandemic, contact precautions were discontinued for MRSA and VRE-infected patients. Rates of hospital-acquired MRSA and VRE infections were compared before and after this intervention, along with hand hygiene proportions. Contact precaution discontinuation did not lead to an increase in hospital-acquired MRSA or VRE infections.

Decoding Surgical Skill: An Objective And Efficient Algorithm For Surgical Skill Classification Based On Surgical Gesture Features -Experimental Studies, Zixin Chen, Dewei Yang, Ang Li, Louzong Sun, Jifan Zhao, Jie Liu, Linxun Liu, Xiaobo Zhou, Yonghua Chen, Yunqiang Cai, Zhong Wu, Ke Cheng, He Cai, Ming Tang, Bing Peng, Xin Wang

Faculty, Staff and Student Publications

BACKGROUND: Various surgical skills lead to differences in patient outcomes and identifying poorly skilled surgeons with constructive feedback contributes to surgical quality improvement. The aim of the study was to develop an algorithm for evaluating surgical skills in laparoscopic cholecystectomy based on the features of elementary functional surgical gestures (Surgestures).

MATERIALS AND METHODS: Seventy-five laparoscopic cholecystectomy videos were collected from 33 surgeons in five hospitals. The phase of mobilization hepatocystic triangle and gallbladder dissection from the liver bed of each video were annotated with 14 Surgestures. The videos were grouped into competent and incompetent based on the quantiles of modified …

Diabetes Study Of Children Of Diverse Ethnicity And Race: Study Design, Maria J Redondo, Kylie K Harrall, Deborah H Glueck, Mustafa Tosur, Serife Uysal, Andrew Muir, Elizabeth G Atkinson, Melanie R Shapiro, Liping Yu, William E Winter, Michael Weedon, Todd M Brusko, Richard Oram, Kendra Vehik, William Hagopian, Mark A Atkinson, Dana Dabelea, Discover Study Group

Faculty, Staff and Students Publications

AIMS: Determining diabetes type in children has become increasingly difficult due to an overlap in typical characteristics between type 1 diabetes (T1D) and type 2 diabetes (T2D). The Diabetes Study in Children of Diverse Ethnicity and Race (DISCOVER) programme is a National Institutes of Health (NIH)-supported multicenter, prospective, observational study that enrols children and adolescents with non-secondary diabetes. The primary aim of the study was to develop improved models to differentiate between T1D and T2D in diverse youth.

MATERIALS AND METHODS: The proposed models will evaluate the utility of three existing T1D genetic risk scores in combination with data on …

Tuberculosis In People Of Ukrainian Origin In The European Union And The European Economic Area, 2019 To 2022, Krista Stoycheva, Veronica Cristea, Csaba Ködmön, Senia Rosales-Klintz, Dominik Zenner, Anca Vasiliu, Marieke Van Der Werf, Christoph Lange

Faculty, Staff and Students Publications

Approximately five million Ukrainians were displaced to the EU/EEA following the Russian invasion of Ukraine. While tuberculosis (TB) notification rates per 100,000 Ukrainians in the EU/EEA remained stable, the number of notified TB cases in Ukrainians increased almost fourfold (mean 2019-2021: 201; 2022: 780). In 2022, 71% cases were notified in three countries, and almost 20% of drug-resistant TB cases were of Ukrainian origin. Targeted healthcare services for Ukrainians are vital for early diagnosis and treatment, and preventing transmission.

Spontaneous Coronary Artery Dissection With Cardiogenic Shock In The United States, Chayakrit Krittanawong, Dhrubajyoti Bandyopadhyay, Neelkumar Patel, Yusuf Kamran Qadeer, Neil Sagar Maitra, Zhen Wang, Mahboob Alam, Samin Sharma, Hani Jneid

Faculty, Staff and Students Publications

BACKGROUND: Spontaneous coronary artery dissection (SCAD) is defined as a non-traumatic separation of the epicardial coronary artery walls that creates a false lumen. SCAD poses a difficult challenge in management, as decisions regarding revascularization and medical management seem to be tailored to the individual patient. We evaluated and compared outcomes based on cardiogenic shock in patients with SCAD utilizing Nationwide Readmissions Database (NRD) between January 1, 2016, to December 30, 2020.

METHODS: We utilized the NRD 2016-2019 to carry out this study. We evaluated demographics (e.g., age, gender), conventional risk factors, comorbidities present on the index admission, and in-hospital outcomes …

Ketamine For Pain In Sickle Cell Disease Reduces Opioid Usage, Christina O Onyebuchi, Corrie E Chumpitazi, Jennifer L Placencia, Andrea N Jackson, Jennifer L Jones, Laura Torres, Venée N Tubman

Faculty, Staff and Students Publications

CONTEXT: Pain attributable to sickle cell disease (SCD) is often unpredictable, recurrent, and requires complex treatments. Subanesthetic ketamine infusion has been studied in other diseases and disorders, but there is still limited data on its efficacy in pain management for SCD.

OBJECTIVES: The primary objective is to determine if subanesthetic ketamine infusion reduces pain scores and opioid requirements in hospitalized pediatric patients with SCD.

RESULTS: Forty-six admissions among 22 patients between February 2018 and December 2019 were analyzed. We observed decrease in pain scores within 24 hours of ketamine initiation in 34 of 46 admissions (mean pain score per patient …

Accuracy And Surface Roughness Of Co-Cr Partial Denture Frameworks With Different Digital Fabrication Methods, Islam Heiba

Dentistry

Statement of problem. Traditional removable partial denture (RPD) manufacture is being phased out in favor of computer-aided design and computer-aided manufacturing (CAD-CAM) techniques and rapid prototyping (RP), which provide more efficient methods of producing RPD frameworks. However, studies comparing the accuracy and surface roughness of these approaches on RPD frameworks are still scarce. Purpose. The purpose of this in vitro study was to evaluate the accuracy and surface roughness of class I cobalt chromium (Co-Cr) removable partial denture frameworks digitally constructed using 2 different CAD-CAM technologies: direct milling (DM) and selective laser melting (SLM). Material and methods. An educational maxillary …

The Impact Of Reflective Writing On Instructional Strategies Development: A Mixed Method Study On Prospective English Language Teachers, Fatema Naser Alshehhi

Theses

Reflective writing is a process in which individuals critically examine their experiences, thoughts, and actions to gain understanding and improve their performance. This thesis investigates the impact of reflective writing on the development of instructional strategies among prospective English language teachers in the United Arab Emirates. The study also explores their perceptions of using reflective writing as a tool for teacher development. The study employed a mixed-methods approach and was conducted in two phases. The first phase involved collecting qualitative data, including document analysis of reflective writings and semi-structured interviews with three prospective teachers. In the second phase, a questionnaire …

Risk Of Malignancy In Renal Biopsy: A Review, Andrew Renshaw

All Publications

The risks of malignancy for cytologic categories in renal biopsy specimens differ from the risks in most other sites. There are obvious areas in which cytopathologists can do better at classifying these cases, and the routine use of immunohistochemistry and core-needle biopsy may improve the accuracy of the classification of these specimens.

Wavelength-Induced Shedding Frequency Modulation Of Seal Whisker Inspired Cylinders, Trevor Dunt, Kirby S. Heck, Kathleen Lyons, Christin Murphy, Raul Bayoan Cal, Jennifer A. Franck

Mechanical and Materials Engineering Faculty Publications and Presentations

The spanwise undulated cylinder geometry inspired by seal whiskers has been shown to alter shedding frequency and reduce fluid forces significantly compared to smooth cylindrical geometry. Undulation wavelength is systematically investigated in order to explore its effect on unsteady lift force and shedding frequency. Prior research has parameterized the whisker-inspired geometry and demonstrated the relevance of geometric variations on force reduction properties. Among the geometric parameters, undulation wavelength was identified as a significant contributor to forcing changes. To analyze the effect of undulation wavelength, a thorough investigation isolating changes in wavelength is performed to expand upon previous research that parameterized …

Barriers And Best Practices On The Management Of Opioid Use Disorder, Michelle Krichbaum

All Publications

Opioids refer to chemicals that agonize opioid receptors in the body resulting in analgesia and sometimes, euphoria. Opiates include morphine and codeine; semi-synthetic opioids include heroin, hydrocodone, oxycodone, and buprenorphine; and fully synthetic opioids include tramadol, fentanyl and methadone. In 2021, an estimated 5.6 million individuals met criteria for opioid use disorder. This article provides an overview of the pharmacology of heroin and non-prescription fentanyl (NPF) and its synthetic analogues, and summarizes the literature related to the management of opioid use disorder, overdose, and withdrawal. This is followed by a description of barriers to treatment and best practices for management …

Current And Future Approaches To Pediatric Anxiety Disorder Treatment, André Zugman, Anderson M. Winkler, Purnima Qamar, Daniel Samuel Pine

School of Medicine Publications

This overview critically appraises the literature on the treatment of pediatric anxiety disorders. The two established treatments for these conditions comprise cognitive-behavioral therapy (CBT) and antidepressant medications. Many youths receiving these treatments fail to achieve remission, which creates a need for new treatments. After summarizing the literature on CBT and currently available medications, the authors describe research that lays a foundation for improvements in the treatment of pediatric anxiety disorders. This foundation leverages neuroscientific investigations, also described in the overview, which provide insights on mechanisms of successful treatment.

Optimization Of Triangular Neutrosophic Based Economic Order Quantity Model Under Preservation Technology And Power Demand With Shortages, S. Loganayaki, N. Rajeswari, K. Kirupa, S. Broumi

Neutrosophic Sets and Systems

The primary objective of this article is to develop a mathematical model and determine the optimal policies of an inventory system involving power demand and controlled deterioration through preservation technology. This model comes in handy in a power demand-oriented inventory system with demand high at the end of the period. The model incorporates backlogged shortages and linear holding cost. The triangular neutrosophic numbers (TNN’s) are used for a nuanced representation of uncertain and imprecise inventory-related expenses. An efficient algorithm is constructed to minimize the total cost, and obtain optimal positive inventory time, optimum cycle time and minimum preservation technology investment. …

Enhancing Medical Image Quality Using Neutrosophic Fuzzy Domain And Multi-Level Enhancement Transforms: A Comparative Study For Leukemia Detection And Classification, A. A. Salama, Mahmoud Y. Shams, Huda E. Khalid, Doaa E. Mousa

Neutrosophic Sets and Systems

Medical image processing has become a critical research area due to the vast amounts of digital image data available. However, medical images often suffer from poor illumination and low visibility of significant structures, requiring image enhancement to improve image quality before processing. In this paper, we propose a technique for enhancing medical images by removing noise and improving contrast based on three different enhancing transforms. The proposed technique embeds the image into a neutrosophic fuzzy domain, where it is mapped into three different levels of trueness, falseness, and indeterminacy, and each level is processed individually using the enhancement transforms. We …

A Novel Method For Solving The Time-Dependent Shortest Path Problem Under Bipolar Neutrosophic Fuzzy Arc Values, Vidhya K, Saraswathi A, Broumi Said

Neutrosophic Sets and Systems

The Shortest path problem is highly relevant in our daily lives, addressing uncertainties like traffic conditions and weather variations. To handle such uncertainties, we utilize Fuzzy Numbers. This paper focuses on Bipolar Neutrosophic Fuzzy Numbers, which have dual positive and negative aspects. They provide a robust framework for representing arc (node/edge) weights, signifying uncertain travel times between nodes. Importantly, these weights can change over time in bipolar neutrosophic fuzzy graphs. Our study introduces an extended Bellman-Ford Algorithm for identifying optimal paths and minimum times with time-dependent Bipolar Neutrosophic Fuzzy arc weights. We demonstrate its effectiveness through a step-by-step numerical example …

Neutrosophic Doubt Fuzzy Bi-Ideal Of Bs-Algebras, P. Ayesha Parveen, M. Himaya Jaleela Begum

Neutrosophic Sets and Systems

In this research paper, our aim is to introduce the new concept of neutrosophic doubt fuzzy bi-ideal of BS algebras as an extension of doubt fuzzy bi-ideal of BS-algebras and investigated its algebraic nature. Neutrosophic doubt fuzzy bi-ideal of BS-algebras is also applied in Cartesian product. Finally, we also provide the homomorphic behaviour of Neutrosophic doubt fuzzy bi-ideal of BS-algebras.

Neutrosophic Vision Of The Expected Opportunity Loss Criterion (Neol) Decision Making Under Risk, Maissam Jdid, Florentin Smarandache

Neutrosophic Sets and Systems

One of the major challenges facing decision-makers at the present time is obtaining complete information about the issue under study, due to the unstable conditions of the work environment that are beyond the control of decision-makers, which requires them to reach an optimal decision in light of these circumstances and fluctuations and to benefit from the data that is collected. Collected by specialists to determine the appropriate probability distribution corresponding to random cases of nature, here we are faced with the issue of making a decision in the event of risk because the probability distribution is a distribution linked to …

Production Planning With The Neutrosophic Fuzzy Multi-Objective Optimization Technique, Şule Bayazit Bedirhanoğlu, Mahmut Atlas

Neutrosophic Sets and Systems

Businesses want to realize their production at the desired time and quality. In addition, businesses aim to use their existing resources efficiently and increase their earnings. The realization of more than one purpose is achieved by multi-purpose planning of production. This study considered the multi-objective production planning of a company that manufactures spare parts for household appliances. The management of the company wants to minimize its cost, cycle time, defective rates, and material wastage while maximizing its profits in the process of producing all 121 different products. This study presents a solution for this multi-item multi-objective production problem using the …

Evaluation Of Sustainable Waste Valorization Using Treesoft Set With Neutrosophic Sets, Ali Alqazzaz, Karam M. Sallam

Neutrosophic Sets and Systems

This study proposed a neutrosophic set framework with TreeSoft Set for sustainable waste valorization selection. The neutrosophic set is used to overcome uncertainty and vague information in the evaluation process. The neutrosophic set has three membership degrees: truth, indeterminacy, and falsity. The multi criteria decision-making (MCDM) methodology deals with various criteria to evaluate waste valorization. The VIKOR method is an MCDM method used to rank the alternatives. The numerical example was created with 12 criteria and 10 alternatives. Three decision-makers and experts are invited to evaluate the requirements and options. We used the bipolar neutrosophic numbers to replace the opinions …

Modeling Influenced Criteria In Classifiers' Imbalanced Challenges Based On Trss Bolstered By The Vague Nature Of Neutrosophic Theory, Ibrahim El-Henawy, Shrouk El-Amir, Mona Mohamed, Florentin Smarandache

Neutrosophic Sets and Systems

Because of the advancements in technology, classification learning has become an essential activity in today's environment. Unfortunately, through the classification process, we noticed that the classifiers are unable to deal with the imbalanced data, which indicates there are many more instances (majority instances) in one class than in another. Identifying an appropriate classifier among the various candidates is a time-consuming and complex effort. Improper selection can hinder the classification model's ability to provide the right outcomes. Also, this operation requires preference among a set of alternatives by a set of criteria. Hence, multi-criteria decision making (MCDM) methodology is the appropriate …

New Fixed Point Results In Neutrosophic Metric Spaces, Umar Ishtiaq, Fahim Ud Din, Mureed Qasim, Lakhdar Ragoub, Khalil Javed

Neutrosophic Sets and Systems

In this manuscript, we give the generalization of banach’s, Kannan’s and Chatterjee’s fixed Point theorems in neutrosophic metric spaces by using new (TS-IF⍺) contractive mappings. Also, we establish common fixed point results in neutrosophic metric space by using Occasionally weakly compatible maps for integral type inequalities.

Neutrosophic Sets And Systems, Vol. 65,2024, Florentin Smarandache, Mohamed Abdel-Basset, Said Broumi

Neutrosophic Sets and Systems

No abstract provided.

Autoantibodies, Antigen-Autoantibody Complexes And Antigens Complement Ca125 For Early Detection Of Ovarian Cancer, Chae Young Han, Jacob S Bedia, Wei-Lei Yang, Sarah J Hawley, Lindsay Bergan, Marika Hopper, Joseph Celestino, Jing Guo, Terrie G Gornet, Antoninus Soosaipillai, Hailing Yang, Samantha D Doskocil, Anna E Lokshin, Beverly C Handy, Eleftherios P Diamandis, Richard G Moore, Karen H Lu, Zhen Lu, Karen S Anderson, Charles W Drescher, Steven J Skates, Robert C Bast

Faculty, Staff and Student Publications

BACKGROUND: Multiple antigens, autoantibodies (AAb), and antigen-autoantibody (Ag-AAb) complexes were compared for their ability to complement CA125 for early detection of ovarian cancer.

METHODS: Twenty six biomarkers were measured in a single panel of sera from women with early stage (I-II) ovarian cancers (n = 64), late stage (III-IV) ovarian cancers (186), benign pelvic masses (200) and from healthy controls (502), and then split randomly (50:50) into a training set to identify the most promising classifier and a validation set to compare its performance to CA125 alone.

RESULTS: Eight biomarkers detected ≥ 8% of early stage cases at 98% specificity. …

Amyopathic Dermatomyositis May Be On The Spectrum Of Autoinflammatory Disease: A Clinical Review, Saika Sharmeen, Lisa Christopher-Stine, Joann N Salvemini, Peter Gorevic, Richard Clark, Qingping Yao

Faculty, Staff and Student Publications

Systemic autoinflammatory diseases (SAIDs) are distinct from autoimmune diseases. The former primarily results from abnormal innate immune response and genetic testing is crucial for disease diagnosis. Similar cutaneous involvement is a main feature for both SAID and dermatomyositis (DM), so they can be confused with each other. A literature search of PubMed and MEDLINE was conducted for relevant articles. The similarities and differences between these two types of diseases were analyzed. We found phenotypic similarities between these two types of disorders. Accumulating data supports a major role of the innate immune system and a similar cytokine profile. Molecular testing using …

Safety And Tolerability Of Phenylbutyrate In Inclusion Body Myositis, Duaa Jabari, Andrew Heim, Ali Ciersdorff, Heather M. Wilkins, Abdulbaki Agbas, Edina Kosa, Suzanne Hunt, Mamatha Pasnoor, Mazen M. Dimachkie, Richard J. Barohn

Faculty and Staff Publications

Introduction

Phenylbutyrate (PBA) showed positive effect on the muscle cell model of Inclusion Body Myositis (IBM) by improving lysosomal activity, ameliorating consequences of impaired autophagy, and decreasing vacuolization. This provides rationale to study this medication in patients with IBM.

Objectives

To evaluate the safety and tolerability of phenylbutyrate in IBM, and monitor for any early signal of effectiveness.

Methods

Open-label study of 10 subjects with IBM who received treatment with PBA for 3 months after a 3-month run-in period. The PBA dose was 3 gm twice daily. The primary outcome measure was adverse event reporting. Secondary outcome measures included manual …

Oblique Anterior Column Realignment With A Mini-Open Posterior Column Osteotomy For Minimally Invasive Adult Spinal Deformity Correction: Illustrative Case, Zach Pennington, Nolan J. Brown, Seyedamirhossein Pishva, Hernán F.J. González, Martin H. Pham

Student Publications

BACKGROUND Adult spinal deformity (ASD) occurs from progressive anterior column collapse due to disc space desiccation, compression fractures, and autofusion across disc spaces. Anterior column realignment (ACR) is increasingly recognized as a powerful tool to address ASD by progressively lengthening the anterior column through the release of the anterior longitudinal ligament during lateral interbody approaches. Here, we describe the application of minimally invasive ACR through an oblique antepsoas corridor for deformity correction in a patient with adult degenerative scoliosis and significant sagittal imbalance.

OBSERVATIONS A 65-year-old female with a prior history of L4–5 transforaminal lumbar interbody fusion and morbid obesity …

A Cadaveric Study Of The Deep And Superficial Dorsal Veins For Penile Transplant, Sirai Ramirez, Nawsin Baset, Andrew Brevik, Nathaniel Ballek, Alyssa Kendell, Ryan Schiller, Anthony Olinger

Student Publications

Objective: It is crucial to know the lengths of the neurovasculature proximal to a penile allograft to allow for better viability of a penile transplant. We performed a cadaveric exploration focused on the deep and superficial dorsal veins as identified in a microsurgical dissection of the penis to help expand the anatomical knowledge for such a procedure.

Methods: We examined 18 cadavers and measured the (1) vertical distance from the pubic symphysis to the point at which the superficial dorsal vein is no longer on the erectile tissue; (2) point at which the superficial dorsal vein is no …

Play Time: Gender, Anti-Semitism And Temporality In Medieval Biblical Drama By Daisy Black (Review), Christopher B. Swift

Publications and Research

No abstract provided.

Desirability Of Outcome Ranking For Obstetrical Trials: Illustration And Application To The Arrive Trial, Grecio J Sandoval, William A Grobman, Scott R Evans, Madeline M Rice, Rebecca G Clifton, Suneet P Chauhan, Maged M Costantine, Kelly S Gibson, Monica Longo, Torri D Metz, Emily S Miller, Samuel Parry, Uma M Reddy, Dwight J Rouse, Hyagriv N Simhan, John M Thorp, Alan T N Tita, George R Saade

Faculty, Staff and Student Publications

BACKGROUND: In randomized trials, 1 primary outcome is typically chosen to evaluate the consequences of an intervention, whereas other important outcomes are relegated to secondary outcomes. This issue is amplified for many obstetrical trials in which an intervention may have consequences for both the pregnant person and the child. In contrast, desirability of outcome ranking, a paradigm shift for the design and analysis of clinical trials based on patient-centric evaluation, allows multiple outcomes-including from >1 individual-to be considered concurrently.

OBJECTIVE: This study aimed to describe desirability of outcome ranking methodology tailored to obstetrical trials and to apply the methodology to …

Image-Based Multiplex Immune Profiling Of Cancer Tissues: Translational Implications A Report Of The International Immuno-Oncology Biomarker Working Group On Breast Cancer, Chowdhury Arif Jahangir, David B Page, Glenn Broeckx, Claudia A Gonzalez, Caoimbhe Burke, Clodagh Murphy, Jorge S Reis-Filho, Amy Ly, Paul W Harms, Rajarsi R Gupta, Michael Vieth, Akira I Hida, Mohamed Kahila, Zuzana Kos, Paul J Van Diest, Sara Verbandt, Jeppe Thagaard, Reena Khiroya, Khalid Abduljabbar, Gabriela Acosta Haab, Balazs Acs, Sylvia Adams, Jonas S Almeida, Isabel Alvarado-Cabrero, Farid Azmoudeh-Ardalan, Sunil Badve, Nurkhairul Bariyah Baharun, Enrique R Bellolio, Vydehi Bheemaraju, Kim Rm Blenman, Luciana Botinelly Mendonça Fujimoto, Octavio Burgues, Alexandros Chardas, Maggie Chon U Cheang, Francesco Ciompi, Lee Ad Cooper, An Coosemans, Germán Corredor, Flavio Luis Dantas Portela, Frederik Deman, Sandra Demaria, Sarah N Dudgeon, Mahmoud Elghazawy, Claudio Fernandez-Martín, Susan Fineberg, Stephen B Fox, Jennifer M Giltnane, Sacha Gnjatic, Paula I Gonzalez-Ericsson, Anita Grigoriadis, Niels Halama, Matthew G Hanna, Aparna Harbhajanka, Steven N Hart, Johan Hartman, Stephen Hewitt, Hugo M Horlings, Zaheed Husain, Sheeba Irshad, Emiel Am Janssen, Tatsuki R Kataoka, Kosuke Kawaguchi, Andrey I Khramtsov, Umay Kiraz, Pawan Kirtani, Liudmila L Kodach, Konstanty Korski, Guray Akturk, Ely Scott, Anikó Kovács, Anne-Vibeke Laenkholm, Corinna Lang-Schwarz, Denis Larsimont, Jochen K Lennerz, Marvin Lerousseau, Xiaoxian Li, Anant Madabhushi, Sai K Maley, Vidya Manur Narasimhamurthy, Douglas K Marks, Elizabeth S Mcdonald, Ravi Mehrotra, Stefan Michiels, Durga Kharidehal, Fayyaz Ul Amir Afsar Minhas, Shachi Mittal, David A Moore, Shamim Mushtaq, Hussain Nighat, Thomas Papathomas, Frederique Penault-Llorca, Rashindrie D Perera, Christopher J Pinard, Juan Carlos Pinto-Cardenas, Giancarlo Pruneri, Lajos Pusztai, Nasir Mahmood Rajpoot, Bernardo Leon Rapoport, Tilman T Rau, Joana M Ribeiro, David Rimm, Anne Vincent-Salomon, Joel Saltz, Shahin Sayed, Evangelos Hytopoulos, Sarah Mahon, Kalliopi P Siziopikou, Christos Sotiriou, Albrecht Stenzinger, Maher A Sughayer, Daniel Sur, Fraser Symmans, Sunao Tanaka, Timothy Taxter, Sabine Tejpar, Jonas Teuwen, E Aubrey Thompson, Trine Tramm, William T Tran, Jeroen Van Der Laak, Gregory E Verghese, Giuseppe Viale, Noorul Wahab, Thomas Walter, Yannick Waumans, Hannah Y Wen, Wentao Yang, Yinyin Yuan, John Bartlett, Sibylle Loibl, Carsten Denkert, Peter Savas, Sherene Loi, Elisabeth Specht Stovgaard, Roberto Salgado, William M Gallagher, Arman Rahman

Faculty, Staff and Student Publications

Recent advances in the field of immuno-oncology have brought transformative changes in the management of cancer patients. The immune profile of tumours has been found to have key value in predicting disease prognosis and treatment response in various cancers. Multiplex immunohistochemistry and immunofluorescence have emerged as potent tools for the simultaneous detection of multiple protein biomarkers in a single tissue section, thereby expanding opportunities for molecular and immune profiling while preserving tissue samples. By establishing the phenotype of individual tumour cells when distributed within a mixed cell population, the identification of clinically relevant biomarkers with high-throughput multiplex immunophenotyping of tumour …