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Venovenous Extracorporeal Membrane Oxygenation Usage Following Bullet Embolism To The Pulmonary Artery, Jonathan E. Schoen, Brian Carr, Murtuza Ali, Brett Chapman, Alan Marr, Lance Stuke, Patrick Greiffenstein, John P. Hunt, Paige Deville, Alison Smith Mar 2024

Venovenous Extracorporeal Membrane Oxygenation Usage Following Bullet Embolism To The Pulmonary Artery, Jonathan E. Schoen, Brian Carr, Murtuza Ali, Brett Chapman, Alan Marr, Lance Stuke, Patrick Greiffenstein, John P. Hunt, Paige Deville, Alison Smith

School of Medicine Faculty Publications

Background: Pulmonary artery embolus is a rare complication following gunshot wounds that creates a unique and serious challenge for trauma surgeons. While the majority of bullets that embolize through the vascular system end in the peripheral circulation, approximately one-third enter the central venous circulation. Case Report: We present the case of a bullet embolus to the left pulmonary artery following gunshot wounds to the right chest and the abdomen, with the abdominal ballistic traversing the liver before entering the vena cava and embolizing. The patient’s course was complicated by the development of severe acute respiratory distress syndrome that was successfully …


Effect Of Implementation Of Mobility Partner In Post-Operative Trauma Surgery Patients In Local Community Hospital, Samantha Finkelstein Md, Joseph J. Stirparo Md Mar 2024

Effect Of Implementation Of Mobility Partner In Post-Operative Trauma Surgery Patients In Local Community Hospital, Samantha Finkelstein Md, Joseph J. Stirparo Md

USF-LVHN SELECT

No abstract provided.


An Evaluation Of The Federal Transition Incentives Program On Land Access For Next-Generation Farmers, Megan Horst, Julia Valliant, Julia Freedgood Mar 2024

An Evaluation Of The Federal Transition Incentives Program On Land Access For Next-Generation Farmers, Megan Horst, Julia Valliant, Julia Freedgood

Urban Studies and Planning Faculty Publications and Presentations

Next-generation farmers face immense challenges in securing land. In recent years, some state- and federal-level land access policy incentives (LAPIs) have been implemented to address these chal­lenges. In this paper, we assess the Transition Incentives Program (TIP), an initiative of the U.S. Department of Agriculture’s Conservation Reserve Program that is funded by Congressional farm bills. TIP offers landowners two years of financial incen­tives for leasing or selling to a beginning or socially disadvantaged farmer or rancher (categories of farmers defined by the U.S. Department of Agri­culture). In our study, we characterize TIP partici­pants to understand where and how TIP assists …


The Wall Between Latinas And Latinos? Gender And Immigration Enforcement Attitudes Among U.S. Latina/O Voters, Álvaro José Corral Mar 2024

The Wall Between Latinas And Latinos? Gender And Immigration Enforcement Attitudes Among U.S. Latina/O Voters, Álvaro José Corral

Political Science Faculty Publications

Donald Trump’s surprising level of support among U.S. Latina/o voters in 2016 and his improved performance in the 2020 election posed a puzzle for Latina/o politics scholars given his stridently anti-immigrant agenda. Although scholars have acknowledged the political gender gap between Latinas and Latino men, few studies have outlined the theoretical basis or explored the empirical existence of gender differences in Latina/o immigration enforcement attitudes. Building on the Latina politics literature documenting Latinas’ greater engagement in solidarity work with immigrants and their greater desire for cultural transmission and the maintenance of pan-ethnic identity, I test two hypotheses. The first (the …


Fair Use In The Us Redux: Reformed Or Still Deformed?, Jane C. Ginsburg Mar 2024

Fair Use In The Us Redux: Reformed Or Still Deformed?, Jane C. Ginsburg

Faculty Scholarship

In 2019, Professor Ginsburg delivered the Distinguished Visitor in Intellectual Property Lecture at the Faculty of Law, National University of Singapore. Titled “Fair Use in the US: Transformed, Reformed, Deformed?”, the lecture explored US caselaw applying the statutory fair use exception, highlighting its excesses and apparent rebalancing. Four and half years (and a pandemic) later, the Supreme Court has rendered decisions in two fair use cases (Google v Oracle; Andy Warhol Foundation v Goldsmith). Together, these controversies prompt inquiry whether the Supreme Court has redrawn the landscape of US fair use and copyright law, expanding fair use …


A Study Of Dietary Patterns Derived By Cluster Analysis And Their Association With Metabolic Dysfunction-Associated Steatotic Liver Disease Severity Among Hispanic Patients, Xiaotao Zhang, Carrie R Daniel, Valeria Soltero, Ximena Vargas, Shilpa Jain, Fasiha Kanwal, Aaron P Thrift, Maya Balakrishnan Mar 2024

A Study Of Dietary Patterns Derived By Cluster Analysis And Their Association With Metabolic Dysfunction-Associated Steatotic Liver Disease Severity Among Hispanic Patients, Xiaotao Zhang, Carrie R Daniel, Valeria Soltero, Ximena Vargas, Shilpa Jain, Fasiha Kanwal, Aaron P Thrift, Maya Balakrishnan

Faculty, Staff and Student Publications

Introduction: Diet is a modifiable metabolic dysfunction-associated steatotic liver disease (MASLD) risk factor, but few studies have been conducted among Hispanic patients, despite the fact that MASLD prevalence and severity are highest among this ethnic subgroup. We aimed to identify prevalent dietary patterns among Hispanic patients using cluster analysis and to investigate associations with MASLD severity.

Methods: This cross-sectional analysis included 421 Harris County MASLD Cohort participants who self-reported Hispanic ethnicity and completed baseline food frequency questionnaires. All included patients had MASLD, diagnosed per standard clinical criteria. K-means analysis was used to identify clusters of patients sharing similar dietary habits. …


Rolling The Dice With Disability Rights: A Critique Of The Exclusion Of Gambling Disorder From The Americans With Disabilities Act, Danielle Oberlander Mar 2024

Rolling The Dice With Disability Rights: A Critique Of The Exclusion Of Gambling Disorder From The Americans With Disabilities Act, Danielle Oberlander

UNLV Gaming Law Journal

No abstract provided.


Casinos, Covid, And Coverage: Jurisprudential And Insurance Implications Of A Litigation Pandemic, Jeffrey W. Stempel Mar 2024

Casinos, Covid, And Coverage: Jurisprudential And Insurance Implications Of A Litigation Pandemic, Jeffrey W. Stempel

UNLV Gaming Law Journal

The onset of the COVID-19 pandemic in early 2020 impacted all walks of American life. Litigation and insurance coverage disputes were no exception. In addition to the impact on dispute resolution procedure (e.g., postponed trials, masked trials, the rise of remote depositions, hearings, and oral argument), there were more than two thousand insurance coverage lawsuits spurred by pandemic-related restrictions on business operations and the resulting lost revenue.

Entertainment and retail venues not deemed “essential” were particularly impacted due to both official government orders closing or restricting operations as well as reduced customer demand stemming from fear of infection. Although some …


Investigating The Mechanisms Through Which Autophagy Controls Lipid Levels In Cyst Stem Cells., Jared Langdon Mar 2024

Investigating The Mechanisms Through Which Autophagy Controls Lipid Levels In Cyst Stem Cells., Jared Langdon

College of Arts & Sciences Senior Theses

With an increase in the average age of the American population, incidents of age-related diseases and illnesses are rising across healthcare communities. Addressing these pathologies with a focus towards novel treatments warrants further research into their mechanistic origins. Lipid build up within cells has been correlated with increased risk for certain pathologies, namely Alzheimer's disease and type-2 diabetes (Demarco, 2020). In this study I aimed to investigate the origin of the increase in lipids, specifically we consider the effects of lipid build up on the maintenance of stem cell populations.


Analysis And Application Of The Offense-Defense Theory: Russia, Ukraine, And History., Kirby Ballard Mar 2024

Analysis And Application Of The Offense-Defense Theory: Russia, Ukraine, And History., Kirby Ballard

College of Arts & Sciences Senior Theses

Political scientists and government advisors have long sought to understand what influences conflicts and how to predict them. Despite constant war, a commonly used empirical theory that can answer this question has not emerged. The majority of theories created are either conflict-specific or not empirically testable. Considering these factors, I sought out a theory that would help me better understand Russia's choice to invade Ukraine in the spring of 2022. I selected the offense-defense theory due to its many attempts to explain territorial conquest, the likeliness of conflict, and overall losses. The main focus of the theory is to explain …


10 The Illusion Of Democracy In Fashion Industry, Deniz Atik, Zeynep Ozdamar Ertekin Mar 2024

10 The Illusion Of Democracy In Fashion Industry, Deniz Atik, Zeynep Ozdamar Ertekin

Marketing Faculty Publications

No abstract provided.


Changes To Digital Commons Author Dashboards, Alice Sherwood Mar 2024

Changes To Digital Commons Author Dashboards, Alice Sherwood

TMC Library Newsletter (2015-)

To provide better service to the growing, and increasingly international, Digital Commons community, Google Maps on  Digital Commons Dashboards Digital Commons Dashboards and Author Dashboards was replaced with Bing Maps. Readership Activity Maps will continue using Google Maps. Although these maps may look slightly different, there is no difference in their functionality.


A Pathway To World Law? International Solidarity As Key To Overcoming Our Current Global Crises, Obiora C. Okafor Mar 2024

A Pathway To World Law? International Solidarity As Key To Overcoming Our Current Global Crises, Obiora C. Okafor

Articles & Book Chapters

This article analyzes the extent to which international solidarity is key to overcoming our current global crises; a goal that must be achieved in robust measure if humanity is to have a chance at successfully constructing the kind of deeply integrated world society that is a pre-condition for the emergence and global acceptance of world law properly so-called. In developing its argument, it devotes the first three sections to relatively in-depth explanations of three concepts that are key to an understanding of the issues at hand, namely: the identity and nature of our current global crises; the idea of world …


Dielectric Properties Of Polycrystalline And Single-Crystal Magnesium Oxide At High Temperatures, Alan Devoe, Hung Trinh, Fatih Dogan Mar 2024

Dielectric Properties Of Polycrystalline And Single-Crystal Magnesium Oxide At High Temperatures, Alan Devoe, Hung Trinh, Fatih Dogan

Materials Science and Engineering Faculty Research & Creative Works

The electrical properties of high-purity magnesium oxide (MgO) samples sintered between 1500 and 1650°C were investigated up to 800°C. Dielectric constant, loss tangent and electrical conductivity were measured between 25 and 800°C. Optimum electrical properties were obtained for the sample sintered at 1600°C. The impurities in polycrystalline and single crystal MgO were discussed to understand their effect on electrical properties and the role of grain boundaries. Higher dielectric losses of polycrystalline samples as compared to the single crystal MgO were attributed to the presence of grain boundaries. MgO could be a useful dielectric material for capacitor applications up to 600°C.


No. 14, March 2024: Advancing Coherence: Aligning Educator Preparation With California’S English Learner Roadmap Policy, Magaly Lavadenz, Ph.D., Anaida Colón-Muñiz, Ed.D., Elvira G. Armas, Ed.D. Mar 2024

No. 14, March 2024: Advancing Coherence: Aligning Educator Preparation With California’S English Learner Roadmap Policy, Magaly Lavadenz, Ph.D., Anaida Colón-Muñiz, Ed.D., Elvira G. Armas, Ed.D.

Education and Policy Briefs

The purpose of this brief is to support English Learner success by encouraging stronger alignment between educator preparation efforts in IHEs and TK-12 policies and practices The current study explores the implementation and alignment of core concepts of the California English Learner Roadmap (ELR) in institutions of higher education (IHEs) – where the majority of California’s future educators are being prepared to serve our students. Researchers conducted a rigorous inquiry process to analyze the degree to which educator program expectations for teaching, school counseling, and administration/leadership are aligned to the ELR. Findings reveal that that there is currently insufficient alignment …


Using Ubuntu As A Research Paradigm To Unpack How Ghanaian Novice Teachers And Their Collaborators Engaged Virtually In Collaborative International Qualitative Research, Adeline M. Borti, Rakesh K. Maurya, Ivy S. Jones-Mensah, Thilina I. Wickramaarachchi Mar 2024

Using Ubuntu As A Research Paradigm To Unpack How Ghanaian Novice Teachers And Their Collaborators Engaged Virtually In Collaborative International Qualitative Research, Adeline M. Borti, Rakesh K. Maurya, Ivy S. Jones-Mensah, Thilina I. Wickramaarachchi

Open Access Publishing Support Funded Articles

The article details how Ubuntu was incorporated into each step of the research project, shares the authors’ experiences and key learnings, and provides recommendations for researchers utilizing Ubuntu as a research paradigm. Ubuntu is an ancient African philosophy emphasizing a way of life grounded in interdependence, collaboration, harmony, and community. In recent years, researchers have incorporated Ubuntu as a research paradigm to decolonize research in a sub-Saharan African context. The present article used international collaborative qualitative research conducted virtually during the COVID-19 pandemic to demonstrate the application of Ubuntu as a research paradigm for conducting research in the African context. …


First Egg Dates Of Tree Swallows (Tachycineta Bicolor) Nesting In Boxes In West Michigan Advanced With Increasing Spring Temperatures Between 1993 And 2018, Michael P. Lombardo, Nathaniel Wagner, Jared M. Laughlin, Sango Otieno, Levi Rosendall, Clara Voetberg, Alejandro Hoban Mar 2024

First Egg Dates Of Tree Swallows (Tachycineta Bicolor) Nesting In Boxes In West Michigan Advanced With Increasing Spring Temperatures Between 1993 And 2018, Michael P. Lombardo, Nathaniel Wagner, Jared M. Laughlin, Sango Otieno, Levi Rosendall, Clara Voetberg, Alejandro Hoban

Open Access Publishing Support Funded Articles

Many bird species have advanced their first egg dates in response to recent milder winters and increases in spring temperatures. Tree Swallows (Tachycineta bicolor) begin egg laying earlier in warmer springs at most, but not all, study sites. We examined whether Tree Swallows that nested in boxes in west Michigan responded to an increase in spring temperatures from 1993 to 2018 by advancing their first egg dates. May, but not April, mean daily temperatures got significantly warmer from 1993 to 2018. We found that the first egg dates, but not mean first egg dates, of both second year …


Deep Reinforcement Learning For Online Scheduling Of Photovoltaic Systems With Battery Energy Storage Systems, Yaze Li, Jingxian Wu, Yanjun Pan Mar 2024

Deep Reinforcement Learning For Online Scheduling Of Photovoltaic Systems With Battery Energy Storage Systems, Yaze Li, Jingxian Wu, Yanjun Pan

Electrical Engineering Faculty Publications and Presentations

A new online scheduling algorithm is proposed for photovoltaic (PV) systems with battery-assisted energy storage systems (BESS). The stochastic nature of renewable energy sources necessitates the employment of BESS to balance energy supplies and demands under uncertain weather conditions. The proposed online scheduling algorithm aims at minimizing the overall energy cost by performing actions such as load shifting and peak shaving through carefully scheduled BESS charging/discharging activities. The scheduling algorithm is developed by using deep deterministic policy gradient (DDPG), a deep reinforcement learning (DRL) algorithm that can deal with continuous state and action spaces. One of the main contributions of …


Novel Avenues Of Tau Research, Claire E Sexton, Gal Bitan, Kathryn R Bowles, Miroslaw Brys, Luc Buée, Mahmoud Bukar Maina, Claire D Clelland, Ann D Cohen, John F Crary, Jeffrey L Dage, Kristophe Diaz, Bess Frost, Li Gan, Alison M Goate, Lawrence I Golbe, Oskar Hansson, Celeste M Karch, Hartmuth C Kolb, Renaud La Joie, Suzee E Lee, Diana Matallana, Bruce L Miller, Chiadi U Onyike, Yakeel T Quiroz, Jessica E Rexach, Jonathan D Rohrer, Amy Rommel, Ghazaleh Sadri-Vakili, Suzanne E Schindler, Julie A Schneider, Reisa A Sperling, Charlotte E Teunissen, Stacie C Weninger, Susan L Worley, Hui Zheng, Maria C Carrillo Mar 2024

Novel Avenues Of Tau Research, Claire E Sexton, Gal Bitan, Kathryn R Bowles, Miroslaw Brys, Luc Buée, Mahmoud Bukar Maina, Claire D Clelland, Ann D Cohen, John F Crary, Jeffrey L Dage, Kristophe Diaz, Bess Frost, Li Gan, Alison M Goate, Lawrence I Golbe, Oskar Hansson, Celeste M Karch, Hartmuth C Kolb, Renaud La Joie, Suzee E Lee, Diana Matallana, Bruce L Miller, Chiadi U Onyike, Yakeel T Quiroz, Jessica E Rexach, Jonathan D Rohrer, Amy Rommel, Ghazaleh Sadri-Vakili, Suzanne E Schindler, Julie A Schneider, Reisa A Sperling, Charlotte E Teunissen, Stacie C Weninger, Susan L Worley, Hui Zheng, Maria C Carrillo

Faculty, Staff and Students Publications

INTRODUCTION: The pace of innovation has accelerated in virtually every area of tau research in just the past few years.

METHODS: In February 2022, leading international tau experts convened to share selected highlights of this work during Tau 2022, the second international tau conference co-organized and co-sponsored by the Alzheimer's Association, CurePSP, and the Rainwater Charitable Foundation.

RESULTS: Representing academia, industry, and the philanthropic sector, presenters joined more than 1700 registered attendees from 59 countries, spanning six continents, to share recent advances and exciting new directions in tau research.

DISCUSSION: The virtual meeting provided an opportunity to foster cross-sector collaboration …


Autophagy Differentially Regulates Tissue Tolerance Of Distinct Target Organs In Graft-Versus-Host Disease Models, Katherine Oravecz-Wilson, Emma Lauder, Austin Taylor, Laure Maneix, Jeanine L Van Nostrand, Yaping Sun, Lu Li, Dongchang Zhao, Chen Liu, Pavan Reddy Mar 2024

Autophagy Differentially Regulates Tissue Tolerance Of Distinct Target Organs In Graft-Versus-Host Disease Models, Katherine Oravecz-Wilson, Emma Lauder, Austin Taylor, Laure Maneix, Jeanine L Van Nostrand, Yaping Sun, Lu Li, Dongchang Zhao, Chen Liu, Pavan Reddy

Faculty, Staff and Students Publications

Tissue-intrinsic mechanisms that regulate severity of systemic pathogenic immune-mediated diseases, such as acute graft-versus-host disease (GVHD), remain poorly understood. Following allogeneic hematopoietic stem cell transplantation, autophagy, a cellular stress protective response, is induced in host nonhematopoietic cells. To systematically address the role of autophagy in various host nonhematopoietic tissues, both specific classical target organs of acute GVHD (intestines, liver, and skin) and organs conventionally not known to be targets of GVHD (kidneys and heart), we generated mice with organ-specific knockout of autophagy related 5 (ATG5) to specifically and exclusively inhibit autophagy in the specific organs. When compared with wild-type recipients, …


Ketamine For Pain In Sickle Cell Disease Reduces Opioid Usage, Christina O Onyebuchi, Corrie E Chumpitazi, Jennifer L Placencia, Andrea N Jackson, Jennifer L Jones, Laura Torres, Venée N Tubman Mar 2024

Ketamine For Pain In Sickle Cell Disease Reduces Opioid Usage, Christina O Onyebuchi, Corrie E Chumpitazi, Jennifer L Placencia, Andrea N Jackson, Jennifer L Jones, Laura Torres, Venée N Tubman

Faculty, Staff and Students Publications

CONTEXT: Pain attributable to sickle cell disease (SCD) is often unpredictable, recurrent, and requires complex treatments. Subanesthetic ketamine infusion has been studied in other diseases and disorders, but there is still limited data on its efficacy in pain management for SCD.

OBJECTIVES: The primary objective is to determine if subanesthetic ketamine infusion reduces pain scores and opioid requirements in hospitalized pediatric patients with SCD.

RESULTS: Forty-six admissions among 22 patients between February 2018 and December 2019 were analyzed. We observed decrease in pain scores within 24 hours of ketamine initiation in 34 of 46 admissions (mean pain score per patient …


Spontaneous Coronary Artery Dissection With Cardiogenic Shock In The United States, Chayakrit Krittanawong, Dhrubajyoti Bandyopadhyay, Neelkumar Patel, Yusuf Kamran Qadeer, Neil Sagar Maitra, Zhen Wang, Mahboob Alam, Samin Sharma, Hani Jneid Mar 2024

Spontaneous Coronary Artery Dissection With Cardiogenic Shock In The United States, Chayakrit Krittanawong, Dhrubajyoti Bandyopadhyay, Neelkumar Patel, Yusuf Kamran Qadeer, Neil Sagar Maitra, Zhen Wang, Mahboob Alam, Samin Sharma, Hani Jneid

Faculty, Staff and Students Publications

BACKGROUND: Spontaneous coronary artery dissection (SCAD) is defined as a non-traumatic separation of the epicardial coronary artery walls that creates a false lumen. SCAD poses a difficult challenge in management, as decisions regarding revascularization and medical management seem to be tailored to the individual patient. We evaluated and compared outcomes based on cardiogenic shock in patients with SCAD utilizing Nationwide Readmissions Database (NRD) between January 1, 2016, to December 30, 2020.

METHODS: We utilized the NRD 2016-2019 to carry out this study. We evaluated demographics (e.g., age, gender), conventional risk factors, comorbidities present on the index admission, and in-hospital outcomes …


Temperature Forecasts For The Continental United States: A Deep Learning Approach Using Multidimensional Features, Jahangir Ali, Linyin Cheng Mar 2024

Temperature Forecasts For The Continental United States: A Deep Learning Approach Using Multidimensional Features, Jahangir Ali, Linyin Cheng

Geosciences Faculty Publications and Presentations

Accurate weather forecasts are critical for saving lives, emergency services, and future developments. Climate models such as numerical weather prediction models have made significant advancements in weather forecasts, but these models are computationally expensive and can be subject to inaccurate representations of complex natural interconnections. Alternatively, data-driven machine learning methods have provided new dimensions in assisting weather forecasts. In this study, we used convolutional neural networks (CNN) to assess how geopotential height at different levels of the troposphere may affect the predictability of extreme surface temperature (t2m) via two cases. Specifically, we analyzed temperature forecasts over the continental United States …


Wilson’S Disease Presenting As Status Epilepticus: A Case Report, Iqra Athar, Neelma Naz Khattak, Hania Batool, Tehreem Farah, Tashfain Shifa, Zukhruf Zayian Mar 2024

Wilson’S Disease Presenting As Status Epilepticus: A Case Report, Iqra Athar, Neelma Naz Khattak, Hania Batool, Tehreem Farah, Tashfain Shifa, Zukhruf Zayian

Pakistan Journal of Neurological Sciences (PJNS)

ABSTRACT

Wilson’s disease (WD) is a rare disorder of copper metabolism, caused by a mutation in the ATPB7 gene, resulting in a defect in copper elimination leading to its accumulation in various organs, with the liver being the most common. Here, we describe a case of a 19-year-old boy who presented with a history of hallucinations and status epilepticus. Initial investigations were normal, but due to a rising trend in alanine transaminase (ALT), a slit lamp examination was performed, revealing Kayser-Fleischer (KF) rings in the eyes. The patient was diagnosed with WD due to the presence of these KF rings …


Effects Of Maternal Subclinical Hypothyroidism On Neurodevelopment Of Offspring- An Animal-Based Study, Sabah Farhat, Syeda Sadia Fatima, Mehir Un Nisa Iqbal, Fazal Arain Mar 2024

Effects Of Maternal Subclinical Hypothyroidism On Neurodevelopment Of Offspring- An Animal-Based Study, Sabah Farhat, Syeda Sadia Fatima, Mehir Un Nisa Iqbal, Fazal Arain

Pakistan Journal of Neurological Sciences (PJNS)

ABSTRACT

Background and objective:

Maternal subclinical hypothyroidism (SCH) during pregnancy is associated with adverse maternal and neonatal outcomes, including cognitive and neuropsychiatric effects. This study aimed to assess the impact of maternal SCH on young rats, examining behavioral and gross brain structure changes, and evaluating reversibility after levothyroxine treatment.

Methods:

This experimental animal study was conducted at the Aga Khan University for a duration of 10 months. The study was approved by the Ethical committee for Animal Care and Use. Fourteen female Sprague Dawley rats were grouped into Treated (induced with SCH, treated with levothyroxine), Untreated (induced with SCH, no …


Recent Literature, Claire M. Stuyck Mar 2024

Recent Literature, Claire M. Stuyck

North American Bird Bander

No abstract provided.


Predation Of A Barred Owl By Another Barred Owl, Hannah Landwerlen, Jadine Lee, Ed Pike Mar 2024

Predation Of A Barred Owl By Another Barred Owl, Hannah Landwerlen, Jadine Lee, Ed Pike

North American Bird Bander

No abstract provided.


Incongruity Between T Cell Receptor Recognition Of Breast Cancer Hotspot Mutations Esr1 Y537s And D538g Following Exogenous Peptide Loading Versus Endogenous Antigen Processing, Paul Shafer, Wingchi K Leung, Mae Woods, Jong Min Choi, Carlos M Rodriguez-Plata, Arushana Maknojia, Andres Mosquera, Lauren K Somes, Jarrett Joubert, Anthony Manliguez, Rashi Ranjan, Bryan Burt, Hyun-Sung Lee, Bing Zhang, Suzanne Fuqua, Cliona Rooney, Ann M Leen, Valentina Hoyos Mar 2024

Incongruity Between T Cell Receptor Recognition Of Breast Cancer Hotspot Mutations Esr1 Y537s And D538g Following Exogenous Peptide Loading Versus Endogenous Antigen Processing, Paul Shafer, Wingchi K Leung, Mae Woods, Jong Min Choi, Carlos M Rodriguez-Plata, Arushana Maknojia, Andres Mosquera, Lauren K Somes, Jarrett Joubert, Anthony Manliguez, Rashi Ranjan, Bryan Burt, Hyun-Sung Lee, Bing Zhang, Suzanne Fuqua, Cliona Rooney, Ann M Leen, Valentina Hoyos

Faculty, Staff and Students Publications

T cell receptor engineered T cell (TCR T) therapies have shown recent efficacy against certain types of solid metastatic cancers. However, to extend TCR T therapies to treat more patients across additional cancer types, new TCRs recognizing cancer-specific antigen targets are needed. Driver mutations in AKT1, ESR1, PIK3CA, and TP53 are common in patients with metastatic breast cancer (MBC) and if immunogenic could serve as ideal tumor-specific targets for TCR T therapy to treat this disease. Through IFN-γ ELISpot screening of in vitro expanded neopeptide-stimulated T cell lines from healthy donors and MBC patients, we identified reactivity towards 11 of …


The Past, Present, And Future Of Predator–Prey Interactions In A Warming World: Using Species Distribution Modeling To Forecast Ectotherm–Endotherm Niche Overlap, Jessica L. Hill, Matthew Grisnik, Ryan J. Hanscom, Jeet Sukumaran, Timothy E. Higham, Rulon W. Clark Mar 2024

The Past, Present, And Future Of Predator–Prey Interactions In A Warming World: Using Species Distribution Modeling To Forecast Ectotherm–Endotherm Niche Overlap, Jessica L. Hill, Matthew Grisnik, Ryan J. Hanscom, Jeet Sukumaran, Timothy E. Higham, Rulon W. Clark

Biology

Climate change has the potential to disrupt species interactions across global ecosystems. Ectotherm–endotherm interactions may be especially prone to this risk due to the possible mismatch between the species in physiological response and performance. However, few studies have examined how changing temperatures might differentially impact species' niches or available suitable habitat when they have very different modes of thermoregulation. An ideal system for studying this interaction is the predator–prey system. In this study, we used ecological niche modeling to characterize the niche overlap and examine biogeography in past and future climate conditions of prairie rattlesnakes (Crotalus viridis) and Ord's kangaroo …


Understanding The Impact Of Adverse Childhood Experiences On Non-Suicidal Self-Injury In Youth: A Systematic Review, Sadia Suhail Usmani, Meghana Mehendale, Mahnoor Yousif Shaikh, Sourav Sudan, Prathima Guntipalli, Lara Ouellette, Anem Sajid Malik, Naila Siddiqi, Namrata Walia, Kaushal Shah, Fahimeh Saeed, Domenico De Berardis, Sheikh Shoib Mar 2024

Understanding The Impact Of Adverse Childhood Experiences On Non-Suicidal Self-Injury In Youth: A Systematic Review, Sadia Suhail Usmani, Meghana Mehendale, Mahnoor Yousif Shaikh, Sourav Sudan, Prathima Guntipalli, Lara Ouellette, Anem Sajid Malik, Naila Siddiqi, Namrata Walia, Kaushal Shah, Fahimeh Saeed, Domenico De Berardis, Sheikh Shoib

Library Staff Publications

OBJECTIVE: Non-suicidal self-injury (NSSI), defined as a deliberate destruction of one's own body without a suicidal intent, is a global public health issue. Adverse childhood events (ACEs) have been shown to be associated with various mental illnesses; however, to date the impact of such events on NSSI in youth has not been reviewed.

METHODS: We conducted a systematic review, searched 5 databases for published articles evaluating ACE and NSSI in youth less than or equal to 21 years of age. After screening 247 articles, we included 21 unique articles in this systematic review.

RESULTS: Increasing ACE score, physical, sexual or …