Digital Commons Network^™

What Weight Changes Really Happened During Covid-19 Among Older Adults?

Faculty, Staff and Students Publications

No abstract provided.

Modified Technique Improves Efficacy For In-Office Posterior Nasal Nerve Ablation, Masayoshi Takashima, Najm S Khan, Nicholas R Rowan, Aria Jafari, Tariq Syed, Omar G Ahmed

Faculty, Staff and Students Publications

Objectives: Posterior nasal nerve (PNN) ablation is a minimally invasive treatment option for patients with chronic rhinitis. Recent evidence shows that parasympathetic innervation of the nasal cavity is more extensive and there are many fibers posterior to the lateral attachment of the middle turbinate. We describe a modified ablative technique that targets the extensive innervation of the posterior nasal nerves.

Methods: Description of the technique and retrospective cohort analysis. In addition to the traditional radiofrequency and cryoablation targets, three additional treatment sites posterior to the middle turbinate were targeted using radiofrequency ablation, as well as one focused treatment posteroinferior to …

Load703, An Oncolytic Virus-Based Immunostimulatory Gene Therapy, Combined With Chemotherapy For Unresectable Or Metastatic Pancreatic Cancer (Lokon001): Results From Arm 1 Of A Non-Randomised, Single-Centre, Phase 1/2 Study, Wasif Abidi, Mohamed Othman, Kalpesh Patel, Salmaan Jawaid, James Jing, Amanda Brisco, Ann M Leen, Mengfen Wu, Linda C Sandin, Jessica Wenthe, Emma Eriksson, Gustav J Ullenhag, Bambi Grilley, Justyna Leja-Jarblad, Susan G Hilsenbeck, Malcolm K Brenner, Angelica S I Loskog

Faculty, Staff and Students Publications

Background: Pancreatic ductal adenocarcinoma is characterised by low immunogenicity and an immunosuppressive tumour microenvironment. LOAd703, an oncolytic adenovirus with transgenes encoding TMZ-CD40L and 4-1BBL, lyses cancer cells selectively, activates cytotoxic T cells, and induces tumour regression in preclinical models. The aim of this study was to evaluate the safety and feasibility of combining LOAd703 with chemotherapy for advanced pancreatic ductal adenocarcinoma.

Methods: LOKON001 was a non-randomised, phase 1/2 study conducted at the Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX, USA, and consisted of two arms conducted sequentially; the results of arm 1 are presented here. …

Development And Publication Of Clinical Practice Parameters, Reviews, And Meta-Analyses: A Report From The Society Of Cardiovascular Anesthesiologists Presidential Task Force, Hilary P Grocott, Bessie Kachulis, Michael L Boisen, Jacob Raphael, Tjorvi E Perry, Hong Liu, Michael C Grant, Jacob Gutsche, Wanda M Popescu, Nadia B Hensley, Michael A Mazzeffi, Roman M Sniecinski, Emily Teeter, Nirvik Pal, Jennie Y Ngai, Alexander Mittnacht, Yianni G T Augoustides, Stephanie O Ibekwe, Archer Kilbourne Martin, Amanda J Rhee, Rachel L Walden, Kathryn Glas, Andrew D Shaw, Linda Shore-Lesserson

Faculty, Staff and Students Publications

The Society of Cardiovascular Anesthesiologists (SCA) is committed to improving the quality, safety, and value that cardiothoracic anesthesiologists bring to patient care. To fulfill this mission, the SCA supports the creation of peer-reviewed manuscripts that establish standards, produce guidelines, critically analyze the literature, interpret preexisting guidelines, and allow experts to engage in consensus opinion. The aim of this report, commissioned by the SCA President, is to summarize the distinctions among these publications and describe a novel SCA-supported framework that provides guidance to SCA members for the creation of these publications. The ultimate goal is that through a standardized and transparent …

Using Starling Murmuration As A Model For Creating A Global Health Community Of Practice To Advance Equity In Scholarship, Anna Mandalakas, Jennifer Benjamin, B Lee Ligon, Satid Thammasitboon

Faculty, Staff and Students Publications

Background: Disparities in scholarship exist between authors in low- or middle-income countries (LMIC) and high-income countries. Recognizing these disparities in our global network providing pediatric, adolescent, and maternal healthcare to vulnerable populations in LMIC, we sought to improve access and provide resources to address educational needs and ultimately impact the broader scholarship disparity.

Methods: We created a virtual community of practice (CoP) program underpinned by principles from starling murmuration to promote interdisciplinary scholarship. We developed guiding principles- autonomy, mastery and purpose- to direct the Global Health Scholarship Community of Practice Program. Program components included a continuing professional development (CPD) program, …

Relevance Of Lymphocyte Proliferation To Pha In Severe Combined Immunodeficiency (Scid) And T Cell Lymphopenia, Elizabeth Dunn, Alison Yip, Malika Kapadia, Neena Kapoor, Lisa Forbes Satter, Rebecca Buckley, Richard O'Reilly, Geoffrey D E Cuvelier, Sharat Chandra, Jeffrey Bednarski, Sonali Chaudhury, Theodore B Moore, Hilary Haines, Blachy J Dávila Saldaña, Deepakbabu Chellapandian, Ahmad Rayes, Karin Chen, Emi Caywood, Shanmuganathan Chandrakasan, Mark Thomas Vander Lugt, Christen Ebens, Pierre Teira, Evan Shereck, Holly Miller, Victor Aquino, Hesham Eissa, Lolie C Yu, Alfred Gillio, Lisa Madden, Alan Knutsen, Ami J Shah, Kenneth Desantes, Jessie Barnum, Larisa Broglie, Avni Y Joshi, Gary Kleiner, Jasmeen Dara, Susan Prockop, Caridad Martinez, Talal Mousallem, Joseph Oved, Lauri Burroughs, Rebecca Marsh, Troy R Torgerson, Jennifer W Leiding, Sung Yun Pai, Donald B Kohn, Michael A Pulsipher, Linda M Griffith, Luigi D Notarangelo, Morton J Cowan, Jennifer Puck, Christopher C Dvorak, Elie Haddad

Faculty, Staff and Students Publications

Severe combined immunodeficiency (SCID) is characterized by a severe deficiency in T cell numbers. We analyzed data collected (n = 307) for PHA-based T cell proliferation from the PIDTC SCID protocol 6901, using either a radioactive or flow cytometry method. In comparing the two groups, a smaller number of the patients tested by flow cytometry had < 10% of the lower limit of normal proliferation as compared to the radioactive method (p = 0.02). Further, in patients with CD3+ T cell counts between 51 and 300 cells/μL, there was a higher proliferative response with the PHA flow assay compared to the 3H-T assay (p < 0.0001), suggesting that the method of analysis influences the resolution and interpretation of PHA results. Importantly, we observed many SCID patients with profound T cell lymphopenia having normal T cell proliferation when assessed by flow cytometry. We recommend this test be considered only as supportive in the diagnosis of typical SCID.

Outcomes Of Extracorporeal Cardiopulmonary Resuscitation For In-Hospital Cardiac Arrest Among Children With Noncardiac Illness Categories, Jessica S Alvey, Jonathan A Race, Lillian Su, Javier J Lasa, Julia C Slovis, Tia T Raymond, Ryan Coleman, Bradley J Barney, Todd J Kilbaugh, Alexis A Topjian, Robert M Sutton, Ryan W Morgan

Faculty, Staff and Students Publications

Objectives: The objective of this study was to determine the association of the use of extracorporeal cardiopulmonary resuscitation (ECPR) with survival to hospital discharge in pediatric patients with a noncardiac illness category. A secondary objective was to report on trends in ECPR usage in this population for 20 years.

Design: Retrospective multicenter cohort study.

Setting: Hospitals contributing data to the American Heart Association's Get With The Guidelines-Resuscitation registry between 2000 and 2021.

Patients: Children (< 18 yr) with noncardiac illness category who received greater than or equal to 30 minutes of cardiopulmonary resuscitation (CPR) for in-hospital cardiac arrest.

Interventions: None.

Measurements and main results: Propensity score weighting balanced ECPR and conventional CPR (CCPR) groups on hospital and patient characteristics. Multivariable logistic regression incorporating …

Deep-Learning-Based Image Super-Resolution Of An End-Expandable Optical Fiber Probe For Application In Esophageal Cancer Diagnostics, Richa Shukla, Shaleen Vasavada, Sharmila Anandasabapathy, Mark A Anastasio, Elena Petrova

Faculty, Staff and Students Publications

SIGNIFICANCE: Endoscopic screening for esophageal cancer (EC) may enable early cancer diagnosis and treatment. While optical microendoscopic technology has shown promise in improving specificity, the limited field of view (

AIM: To improve the efficiency of endoscopic screening, we propose a novel concept of end-expandable endoscopic optical fiber probe for larger field of visualization and for the first time evaluate a deep-learning-based image super-resolution (DL-SR) method to overcome the issue of limited sampling capability.

APPROACH: To demonstrate feasibility of the end-expandable optical fiber probe, DL-SR was applied on simulated low-resolution microendoscopic images to generate super-resolved (SR) ones. Varying the degradation …

Ai-Assisted Reconfiguration Of Battery Packs For Cell Balancing To Extend Driving Runtime, Yuqin Weng, Cristinel Ababei

Electrical and Computer Engineering Faculty Research and Publications

State of charge (SoC) cell balancing is one of the most important roles of battery management systems (BMS). The performance and lifespan of a battery pack can be significantly degraded and reduced by the presence of imbalance in cells SoC. Recently, we have shown that using a machine learning driven battery pack reconfiguration technique based on a network of controllable switches, one can periodically change the battery pack topology to effectively achieve better cell SoC equalization. As a result, the driving runtime achieved with a better balanced battery pack is increased. In this paper, we build on these promising results …

Remotely Sensed Imagery Reveals Animal Feeding Operations Increase Downstream Dissolved Reactive Phosphorus, Andrew G. Meyer, Zach Raff, Sarah Porter

Economics Faculty Research and Publications

In this paper, we use remotely sensed imagery to identify the location and size of animal feeding operations in the Maumee River Watershed, a key drainage area to Lake Erie's Western Basin, which has recently experienced severe harmful algal blooms. We then estimate the relationship between the intensity of animal feeding operations in the watershed and surface water body concentrations of dissolved reactive phosphorus (DRP), the pollutant most responsible for algal growth. We find that stream reaches with relatively larger increases in upstream animal feeding exposure experience significantly higher increases in concentrations of DRP. The average marginal upstream animal feeding …

Situation Awareness Preparation And Prebriefing: Fostering The Cognitive Processes Of Thinking Like A Nurse In Simulation, Amanda Lynn Potter

Dissertations (1934 -)

Situation awareness (SA) is linked with actionable decision-making and clinical judgment in nursing practice. The cognitive processes used in developing SA, outlined in Endsley’s (1995) model, is the framework underpinning this study and are interwoven into the National Council of State Boards of Nursing Clinical Judgment Measurement Model (NCJMM). Cultivating these cognitive processes through prebriefing and simulation designed to intentionally develop SA, is a recommended practice currently seen in aviation and military training. There is a lack of vigorous research testing whether a specific intervention during clinical simulation can develop SA in nursing students. In addition, fostering SA in the …

Antibiotic Resistance In Urban Stormwater Runoff And Green Stormwater Infrastructure, Kassidy N. O'Malley

Dissertations (1934 -)

Antibiotic resistance in the environment poses significant risks to human health, especially through the transmission of antibiotic resistance genes (ARGs) and antibiotic-resistant bacteria (ARB) via pathways like food and water. Urban stormwater runoff has been identified as a significant contributor to the release and transport of ARGs in the environment but has remained under-researched. This dissertation aimed to address this gap by investigating the fate of ARGs in urban stormwater runoff to guide future stormwater management decisions. Two phases were completed; the first sought to investigate extracellular antibiotic resistance genes (eARGs) in stormwater runoff, and the second focused on quantifying …

Arming The Naked Public Square: America’S Catholic Bishops Confront The Reagan Administration, 1980-1983, Brooke Tranten

Dissertations (1934 -)

This dissertation examines 1983 pastoral on war and peace, The Challenge of Peace, from the National Conference of Catholic Bishops (NCCB). It analyzes in-depth the process of the ad hoc committee of the NCCB that wrote the pastoral alongside the simultaneous debates within the American Catholic community and the Reagan administration surrounding the pastoral. Special attention is given here to the interactions of the Reagan administration with the ad hoc committee, led by Archbishop Joseph Bernardin, and the role of American Catholic lay critics Michael Novak, Philip Lawler, and George Weigel. It also explicates the intrapersonal aspect of drafting process, …

The Mental Health Management Of Individuals In Sex Work, Bianca Tocci

Dissertations (1934 -)

ABSTRACT:

This dissertation examines the mental health implications and experiences of individuals engaged in sex work, employing a constructivist grounded theory approach to explore the nuanced realities of this marginalized population. Through in-depth interviews with sex workers, this study reveals the complex interplay of positive aspects (enjoyment and empowerment), and the negative (severe risks faced by individuals in this field, including verbal abuse, physical violence, and sexual assault). The findings underscore the critical need for a holistic and nuanced understanding of sex work, challenging prevalent stereotypes and emphasizing the importance of ongoing consent, communication, and respect for sex workers' boundaries. …

Becoming Hispanic-Serving Institutions (Hsis): Disrupting Institutional Whiteness, Jacqueline Black

Dissertations (1934 -)

Hispanic-Serving Institutions (HSIs) educate disproportionately large percentages of Latinx and other underrepresented minority (URM) postsecondary students. But as most HSIs are also Historically White Colleges, whiteness permeates their campus structures, cultures, and practices. This study bridges gaps in our understanding around how legacies of historical whiteness on campuses that have recently become or are emerging as HSIs affect their efforts to serve Latinx/URM students. The project focuses on the perspectives of those faculty, staff, and administrators most intimately involved in “servingness” work on these campuses: HSI specialists. Employing a critical qualitative approach and guided by Critical Whiteness Studies and Omi …

The Beauty Of A Good Appetite In A Social Media Age, Megan Heeder

Dissertations (1934 -)

This dissertation provides a theological response to eating disorders, disordered eating, and body dissatisfaction, particularly in light of social media’s influence on women and girls. Theologically, eating disorders may be thought of as conditions produced by a debased version of beauty, a self-transcending rather than self-negating conception of kenosis, and a distorted pursuit of goodness or “misguided moralism” that results. Paying particular attention to the feminine thin ideal and its influence on Western beauty standards, this dissertation engages Hans Urs von Balthasar’s theological aesthetics and presentation of kenosis alongside virtue ethics to respond to society’s impoverished vision of beauty and …

An Evaluation Of Probabilistic Delay And Denial Training: Durability Against Treatment Relapse, Kendall Mae Kastner

Dissertations (1934 -)

Delay and Denial Teaching is a prevalent prescribed intervention following successful implementation of Functional Communication Training (FCT). Although there is strong empirical evidence in support of delay and denial teaching as an intervention to reach socially acceptable outcomes, there has yet to be systematic assessments of this intervention’s susceptibility to treatment relapse. The goal of this evaluation is to arrange treatment challenges which mimic the conditions that threaten treatment outcomes in the natural environment, specifically transferring treatment to a new environment or treatment integrity omission errors. Researchers replicated recent iterations of delay and denial teaching procedures (Hanley et al., 2014; …

From Predominantly White To Hispanic-Serving: Latinx Student Experiences On A Campus In Transition, Gabriel M. Velez, Jacqueline Black, Saúl López, Kimberly D'Anna-Hernandez

College of Education Faculty Research and Publications

This study utilized focus groups with Latinx students at a private, Midwestern university to explore the complexities inherent in the process of becoming a Hispanic-Serving Institution (HSI). The purpose of the study was: (a) to better understand Latinx students’ experiences at an “emerging” HSI, and (b) to understand how students understand an institutional journey toward the HSI designation. Findings point toward the value in exploring the Latinx student experience and perspective on HSI initiatives.

Resumen

Este estudio utilizó grupos foco con estudiantes latinx en una Universidad privada, del medio-oeste en EEUU para explorar las complejidades inherentes en el proceso de …

(Wp 2024-02) Stratification Economics: Historical Origins And Theoretical Foundations, John B. Davis

Economics Working Papers

Stratification economics (SE) investigates how economies are organized around group inequalities, especially by race and gender but also by ethnicity, national origin, religion, sexual orientation, etc. Its historical origins and theoretical foundations have both a structural strand that addresses how and a social behavioral strand. SE's structural strand goes back to Ricardo and Marx regarding the relationship between growth and distribution, and then draws on recent economic theory of noncompeting groups and dual economy models of labor market segmentation. SE's structural strand produces an inequality-based understanding of economics' standard goods taxonomy. The social behavioral strand builds on Du Bois's psychological …

Eaat4-Dependent Effects On Glutamatergic Signaling In The Cerebellar Molecular Layer, Christopher Chen

Dissertations (1934 -)

Glutamatergic signaling is fundamental to human behavior and its dysfunction is implicated in a wide range of neurological and neurodegenerative disorders. Excitatory amino-acid transporters (EAATs) – of which four primary subtypes (EAAT1, EAAT2, EAAT3, and EAAT4) exist in the human brain – are primary regulators of glutamate signaling. Endogenously-expressed at either low (EAAT4-low) or high (EAAT4-high) concentration in cerebellar Purkinje cells, EAAT4 has been shown to regulate Purkinje cell activity in the cerebellar molecular layer. However, differences in glutamatergic signaling at the circuit and single-synaptic levels in EAAT4-low and EAAT4-high regions are poorly understood. To characterize EAAT4-specific effects on excitatory …

The Influence Of Preschool Funding On High School Graduation Rates And Economic Status In New Jersey, Theresa Roessner

Walden Dissertations and Doctoral Studies

No abstract provided.

Importance Of Nonprofit Board Training On One Organization’S Efforts To Raise Funding Through Foundations, Marsha Jackson

Walden Dissertations and Doctoral Studies

No abstract provided.

Crisis Support Through Policies For Medical Professionals In 2020 And 2021 During The Covid-19 Pandemic, Malik James Fonville-Simmons

Walden Dissertations and Doctoral Studies

No abstract provided.

Working Memory Gating In Obesity: Insights From A Case-Control Fmri Study, Nadine Herzog, Hendrik Hartmann, Lieneke K. Janssen, Maria Waltmann, Sean J. Fallon, Lorenz Deserno, Annette Horstmann

School of Psychology

Computational models and neurophysiological data propose that a ‘gating mechanism’ coordinates distractor-resistant maintenance and flexible updating of working memory contents: While maintenance of information is mainly implemented in the prefrontal cortex, updating of information is signaled by phasic increases in dopamine in the striatum. Previous literature demonstrates structural and functional alterations in these brain areas, as well as differential dopamine transmission among individuals with obesity, suggesting potential impairments in these processes. To test this hypothesis, we conducted an observational case-control fMRI study, dividing participants into groups with and without obesity based on their BMI. We probed maintenance and updating of …

On Stephen King, And The “What” And “Why” Of American Archivist, Amy Cooper Cary

Library Faculty Research and Publications

The mix of articles in this issue cuts a broad swath through several topics current in our literature, and trying to decide how to bring it all together in an editor's column was giving me fits. An issue that moves from community archives to contingent workers, to promotion and tenure, to congressional collections, to access systems, to engagement—well, it's not easy for me to wrap my editorial head around, let alone for you to thread your way through as a reader. It's a great problem to have, but I needed to make sense of it. Terry Baxter's 2023 SAA Presidential …

Team Psychological Contracts: Effects Of Gender And Social Comparison Orientation, Bonnie S. O'Neill, Martin D. Hassell

Management Faculty Research and Publications

Understanding the psychological contract (PC) perceptions of college students is crucial for attracting and retaining them as early-career employees. We explore how gender and social comparison orientation (SCO) serve as antecedents and moderators of PC breach. Potential PC obligations were examined across 34 teams of full-time business students. Moderated relationships between SCO and gender were examined relative to PC development, breach, and commitment via a survey following a semester-long team project. Results showed that gender significantly influenced obligation perceptions, with females possessing stronger obligations of their team. Positive relationships existed between SCO and the strength of reported obligations and with …

Honing The Craft Of Qualitative Data Collection In Extreme Contexts, Payal Sharma, Madeline Toubiana, Kisha Lashley, Felipe Massa, Kristie M. Rogers, Trish Ruebottom

Management Faculty Research and Publications

Over the past several years, there has been ongoing dialog within our academic journals and the profession regarding the value of examining extreme, unconventional, or unsettling contexts in management research. These conversations have highlighted that perhaps more than ever, we as a society are facing unprecedented grand and perplexing challenges, and conducting research in unconventional or extreme settings can reveal complex dynamics or relationships that we may not understand otherwise. Less discussed, however, are methodological considerations for conducting research in unique contexts. As such, we aim to extend the explicit discussion of effective strategies for scholars who consider the perspectives …

The Feasibility And Acceptability Of A Diabetes Survival Skills Intervention For Persons Transitioning From Prison To The Community, Louise Reagan, Rick A. Laguerre, Sarah Todd, Colleen Gallagher

Management Faculty Research and Publications

Community evidenced-based diabetes self-management education (DSME) models have not been examined for feasibility, acceptability, or effectiveness among persons transitioning from prison to the community to independent diabetes self-management (DSM). In a non-equivalent control group design with repeated measures, we examined the feasibility, acceptability, and preliminary effect of a 6-week, 1-h per week Diabetes Survival Skills (DSS) intervention on diabetes knowledge, distress, self-efficacy, and outcome expectancy for transitioning incarcerated males. Of the 92 participants (84% T2D, 83% using insulin, 40% Black, 20% White, 30% Latino, 66% high school or less, mean age 47.3 years, 84% length of incarceration ≤4 years ), …

Observation Of Seven Astrophysical Tau Neutrino Candidates With Icecube, Karen Andeen

Physics Faculty Research and Publications

We report on a measurement of astrophysical tau neutrinos with 9.7 yr of IceCube data. Using convolutional neural networks trained on images derived from simulated events, seven candidate 𝜈_𝜏 events were found with visible energies ranging from roughly 20 TeV to 1 PeV and a median expected parent 𝜈_𝜏 energy of about 200 TeV. Considering backgrounds from astrophysical and atmospheric neutrinos, and muons from 𝜋^±/𝐾^± decays in atmospheric air showers, we obtain a total estimated background of about 0.5 events, dominated by non-𝜈_𝜏 astrophysical neutrinos. Thus, we rule out the absence of astrophysical 𝜈 …

Psychometric Evaluation Of The “Providing Validation” Measure In Vascular Anomalies, Bryan A. Sisk, Anna M. Kerr, Amy R. Newman, Dandan Chen, Jennifer W. Mack, Bryce B. Reeve

College of Nursing Faculty Research and Publications

We assessed the psychometric properties of the “providing validation” subscale of PedCOM measures for parents of children with vascular anomalies and adult patients. A total of 139 adult patients and 78 parents completed surveys. The mean score for patients was 3.7 (standard deviation 1.0), and for parents was 4.0 (standard deviation 0.9). “Providing validation” measures demonstrated high internal consistency and good model fit to a unidimensional model for both patients and parents using confirmatory factor analysis. The measures also demonstrated convergent validity with co-administered measures. This study demonstrated the validity of “providing validation” measures for parents and adult patients with …