Digital Commons Network^™

Inelastic Dynamic Response Of Two-Story Steel Frame Under Single And Dual Blast Loading, Jack Austin

Civil & Environmental Engineering Theses & Dissertations

This study presents a theoretical investigation of the influence of both single and dual blast loadings and their duration on the inelastic behavior of a two-story steel plane frame. The influence of the type and duration of blast loading on the frame dynamic elasto-plastic response is studied by numerically solving the governing differential equations of dynamic equilibrium. The effects of the degree of damping and steel yield stress on the frame performance are also identified. Terrorist bombings of buildings have become increasingly prevalent and need to be accounted for when designing structures to prevent excessive deformations and collapse that result …

Study Of Deep Learning Models To Classify Nasa’S Kepler Light Curves, Heena Minnich

Computer Science Theses & Dissertations

The search for exoplanets has been an ongoing effort since the first discoveries of planets beyond our solar system in the 1990s. Finding a potentially habitable planet outside our solar system could provide key insights on life elsewhere in the universe. NASA Missions such as the Kepler, launched in 2009 and completed in 2018, have provided a massive amount of data in this goal by using the transit method to discover repetitive and periodic dips in visible light around a star. The transit method has been used to measure flux, the brightness of a star over time. These flux time …

Mitigating Ai’S Harmful Effects In Developing Economies Through Contracting, A.B. Steinberg

The International Law Review Association Student Forum

The global economic community must establish a new organization that helps to create contracting parameters to ensure that AI does not crash economies, namely those in the developing world that are most at risk.

Artificial Intelligence (AI) will revolutionize the global economy. While many debate the ramifications for developed economies, such as the United States, these effects will likely be increased productivity and the loss of jobs across the workforce. This comment argues that these effects will be even more profound in developing nations due to both AI in their direct economies and the downstream effects of automation. The possible …

Collusive Foreclosure Sales: The Forgotten Legacy Of Northern Pacific V. Boyd, David G. Carlson

Articles

In BFP v. Resolution Trust Corp. (1994), the Supreme Court ruled that mortgage foreclosures could not be fraudulent conveyances – unless the foreclosure was “collusive.” It gave no clue what made mortgage foreclosures collusive. But in 1913, the Supreme Court defined collusive mortgage foreclosures in a famous railroad receivership case – Northern Pacific R. Co. v. Boyd. Boyd is usually thought to be the origin of the absolute priority rule in bankruptcy reorganization. Actually, it was a mortgage foreclosure sale. What made the sale collusive is that some of the shareholders of the defaulting railroad were also the shareholders of …

The Role Of Pfkfb3 In Ampk-Activated Glut4 Translocation, Katherine Renee Bosch

Senior Honors Theses

Type 2 diabetes is a chronic, potentially deadly disease that impacts millions of Americans’ lives. Type 2 diabetes is characterized by increased blood glucose levels caused by insulin resistance. The normal insulin signaling pathway leads to glucose uptake by GLUT4 through activation of the IRS-1-PI3K-Akt pathway, as well as the insulin-independent pathway that utilizes AMPK. Additionally, PFKFB3 may play a role in insulin signaling and glucose uptake. PFKFB3 is an enzyme that plays an important role in activating PFK-1, which is a rate-limiting enzyme in glycolysis. PFKFB3 is frequently studied for its role in cancer due to its role in …

Fat Malabsorption: An Underrecognized Challenge From Pancreatic Disease To Trauma, Critical Care, And Beyond., David C Evans

Trauma and Acute Care Articles

No abstract provided.

Truth Anti-Smoking Campaign: Messaging Characteristics And The Use Of Fear, Erin Caine

Departmental Honors & Graduate Capstone Projects

truth® (“truth”) is an anti-smoking campaign that was created to fight against the tobacco industry by showcasing the various health, social, and economic effects of smoking so that young people can make healthy and educated decisions. The purpose of this study is to evaluate the campaign’s rhetorical messaging through a qualitative content analysis across all their social media accounts (Facebook, Instagram, TikTok, and YouTube). Specifically, this study identifies common themes, characteristics, and fear appeal elements used in truth’s messaging. Results of this study indicate that truth’s social media posts adhere to many of the themes and characteristics that were identified …

Pathways To Foster, Develop, And Measure Unity In A Diverse Church Setting, Timothy I. Parsons

Doctor of Ministry (DMin)

Although there is still a long way to go, the Christian church in America is growing more and more diverse. In the same timeframe of the shift to more diversity, America has grown more divided politically, socially, and religiously. Throughout scripture, and especially in the New Testament, God speaks of the power and purpose of a unified church. The early church was required to grow in its diversity while also pursuing unity among all the differences that existed. The church of the twenty-first century and beyond is under the same mandate. This project’s purpose is to uncover, by surveying current …

Spiritual Fathering: Does It Really Make A Difference?, Jeffrey A. Jacob

Doctor of Ministry (DMin)

The importance and impact of having a father in the home is undisputable. Statistics dictate that the effect of fatherlessness on children is devastating. Could it be that having a spiritual father or mother involved in a believer’s life makes a verifiable difference as well? This dissertation will investigate the effects of spiritual fathering as evidenced by the spiritual disciplines of those who identify as having a strong spiritual father or mother. The Apostle Paul said, “Even if you had ten thousand guardians in Christ, you do not have many fathers, for in Christ Jesus I became your father through …

Renouncing The Dominant Script: Weaving Together Mysticism, Monasticism, And Sacramental Theology To Create A Pentecostal Model Of Spiritual Formation, Hilton Burkholder

Doctor of Ministry (DMin)

From political division and culture wars to moral failures, it has become increasingly evident over the last few decades that the Church in North America has a formation problem. This project aims to tackle the issue of discipleship and formation by exploring the development and application of a practical, spirit-led model of spiritual formation for the 21st-century North American Church. By drawing on the rich traditions of monastic, mystical, and sacramental spirituality, this project seeks to create a Pentecostal model of spiritual formation that is communal, charismatic, and embodied, revealing that discipleship is not an end in itself but a …

Evangelship: Mobilizing A Culture Of Discipleship That Leads To Evangelism In A Multiethnic Latino Context, Lawrence D. Perez

Doctor of Ministry (DMin)

Discipleship and evangelism in America today are eroding. Where traditionally the church sees discipleship and evangelism as separate entities, this research project argues for the unification of the two. This project explores “Evangelship,” the uniting of evangelism and discipleship, to see if the combined approach and perspective could offer a better way to engage the North American population. The driving question for this project is “Can the integration of evangelism and discipleship create a culture that accelerates and advances the Great Commission at U-Turn Covenant Church (U-Turn)?” To answer this question, the study aims to establish a discipleship framework that …

Multiply Alabama: Moving From Church Planting To Church Multiplication By Multiplying Leaders And Churches In The Alabama Ministry Network, David P. Strahan

Doctor of Ministry (DMin)

The Alabama Ministry Network has had anemic success in planting over 150 churches since 1980. However, there has still been a ten percent decline in the total number of churches due to churches closing, churches withdrawing, or churches merging. This project studies how AMN can move from addition (church planting) to multiplication (church multiplication) to avoid further regression. The Biblical literature review examines the scriptural premise to multiply. It also discovers the church planting models of Jesus, the early church, and Paul The project used mixed research methods to develop a pathway towards church multiplication within AMN in four phases. …

Improved Accuracy And Efficiency Of Primary Care Fall Risk Screening Of Older Adults Using A Machine Learning Approach, Hannah E Rice, Michael Sainlaire, Lillian Min, Linying Zhang, Tien Thai, Min-Jeoung Kang, Siyun Li, Christian Tejeda, Stuart Lipsitz, Lipika Samal, Diane L Carroll, Lesley Adkison, Lisa Herlihy, Virginia Ryan, David W Bates, Patricia C Dykes

Faculty, Staff and Students Publications

Background: While many falls are preventable, they remain a leading cause of injury and death in older adults. Primary care clinics largely rely on screening questionnaires to identify people at risk of falls. Limitations of standard fall risk screening questionnaires include suboptimal accuracy, missing data, and non-standard formats, which hinder early identification of risk and prevention of fall injury. We used machine learning methods to develop and evaluate electronic health record (EHR)-based tools to identify older adults at risk of fall-related injuries in a primary care population and compared this approach to standard fall screening questionnaires.

Methods: Using patient-level clinical …

Depiction Of Sexual Violence In Indian Films: Viewing From And In A Man/Patriarch’S World, Sudeshna Roy

College of Communication Faculty Research and Publications

The article discusses the depiction of sexual violence in Indian films and its reflection of wider cultural norms. It highlights the pervasive influence of a male perspective throughout the filmmaking process, from producers to audiences. The portrayal of rape and sexual violence in Indian films often focuses on the pain and humiliation of women, the satisfaction of men, and the sadistic pleasure derived from the brutality. The article argues for the need to handle these depictions with sensitivity, maturity, and respect for survivors, and calls for greater representation of women in the filmmaking industry. It also examines the influence of …

The Fallacy Of Auditor Independence And A Possible Solution, Harrison Hall

Senior Honors Theses

The goal of this paper is to analyze present research for the importance of independence to the auditing profession, determine the greatest threats to auditor independence today, the problems these threats have caused and to explore a possible solution to these problems. For many years, audit professionals have been considered the gatekeepers of the public market. Since the passing of the Securities Acts in the 1930’s, the structure of the privatized audit industry has made it incredibly difficult for auditors to remain independent from their clients. Client fees, the rise of non-audit services and the complexity of audit-client relationships pose …

Patent Law 101: I Know It When I See It, Matthew Sipe

Articles

In the decade since its creation by the Supreme Court, the Alice/Mayo test for patentable subject matter under § 101 has been sharply criticized by many — and yet is still without meaningful reform. This Article adds to the corpus by empirically demonstrating a troubling consequence of contemporary § 101 doctrine: panel-dependent outcomes at the Federal Circuit. Specifically, this Article relies on a novel, whole-population dataset (all § 101 decisions made by the Federal Circuit up to 2023, hand-coded on a claim-by-claim basis) under natural-experiment circumstances (random panel assignments). Analysis of that data indicates that which judges are assigned to …

Novel Methods Of Identifying Individual And Neighborhood Risk Factors For Loss To Follow-Up After Ophthalmic Screening, Noah Heilenbach, Titilola Ogunsola, Ceyhun Elgin, Dustin Fry, Mina Iskander, Yara Abazah, Ahmed Aboseria, Rahm Alshamah, Jad Alshamah, Gladys Maestre

School of Medicine Publications

Précis

Residence in a middle-class neighborhood correlated with lower follow-up compared to residence in more affluent neighborhoods. The most common explanations for not following up were the process of making an appointment and lack of symptoms.

Purpose:

To explore which individual and neighborhood-level factors influence follow-up as recommended after positive ophthalmic and primary care screening in a vulnerable population using novel methodologies.

Participants

and Methods: From 2017 to 2018, 957 participants were screened for ophthalmic disease and cardiovascular risk factors as part of the Real-Time Mobile Teleophthalmology study. Individuals who screened positive for either ophthalmic or cardiovascular risk factors were …

The Internist's Post V.1 N.2, The University Of Texas Rio Grande Valley. School Of Medicine, Edgar Dorsey Trevino, Diana Othon Martinez, Jian Garcia Cruz, Eunbee Cho, Roque Mifuji Lira, Martha Solis

School of Medicine Publications

Newsletter of the University of Texas Rio Grande Valley School of Medicine - Internal Medicine Residency Program.

Critical Role Of Histone Deacetylase 3 In The Regulation Of Kidney Inflammation And Fibrosis, Yanlin Wang

Faculty, Staff and Students Publications

Chronic kidney disease (CKD) is characterized by kidney inflammation and fibrosis. However, the precise mechanisms leading to kidney inflammation and fibrosis are poorly understood. Since histone deacetylase is involved in inflammation and fibrosis in other tissues, we examined the role of histone deacetylase 3 (HDAC3) in the regulation of inflammation and kidney fibrosis. HDAC3 is induced in the kidneys of animal models of CKD but mice with conditional HDAC3 deletion exhibit significantly reduced fibrosis in the kidneys compared with control mice. The expression of proinflammatory and profibrotic genes was significantly increased in the fibrotic kidneys of control mice, which was …

Temporary Peripheral Nerve Stimulation For The Treatment Of Greater Occipital Neuralgia

Faculty, Staff and Students Publications

Background: Greater occipital neuralgia (GON), a cause of chronic headaches, can be debilitating and vastly affect one's quality of life. Recent strides in comprehending the pathophysiology of GON and the ongoing evolution of approaches to the condition's treatment have led to the pursuit of more effective interventions. Among these, temporary peripheral nerve stimulation (PNS) devices have surfaced as an avenue for management, presenting a minimally invasive yet highly efficient alternative in treating other chronic pain conditions. This study discusses a case of GON successfully managed with temporary (60-day) PNS.

Case report: A 35-year-old man presented with a nearly 8-month history …

Analytical Challenges In Omics Research On Asthma And Allergy: A National Institute Of Allergy And Infectious Diseases Workshop, Supinda Bunyavanich, Patrice M Becker, Matthew C Altman, Jessica Lasky-Su, Carole Ober, Karsten Zengler, Evgeny Berdyshev, Richard Bonneau, Talal Chatila, Nilanjan Chatterjee, Kian Fan Chung, Colleen Cutcliffe, Wendy Davidson, Gang Dong, Gang Fang, Patricia Fulkerson, Blanca E Himes, Liming Liang, Rasika A Mathias, Shuji Ogino, Joseph Petrosino, Nathan D Price, Eric Schadt, James Schofield, Max A Seibold, Hanno Steen, Lisa Wheatley, Hongmei Zhang, Alkis Togias, Kohei Hasegawa

Center for Medical Ethics and Health Policy Staff Publications

Studies of asthma and allergy are generating increasing volumes of omics data for analysis and interpretation. The National Institute of Allergy and Infectious Diseases (NIAID) assembled a workshop comprising investigators studying asthma and allergic diseases using omics approaches, omics investigators from outside the field, and NIAID medical and scientific officers to discuss the following areas in asthma and allergy research: genomics, epigenomics, transcriptomics, microbiomics, metabolomics, proteomics, lipidomics, integrative omics, systems biology, and causal inference. Current states of the art, present challenges, novel and emerging strategies, and priorities for progress were presented and discussed for each area. This workshop report summarizes …

Learning From Data In Dentistry: Summary Of The Third Annual Openwide Conference, Elsbeth Kalenderian, Kawtar Zouaidi, Jan Yeager, Janelle Urata, Alfa Yansane, Bunmi Tokede, Donald B. Rindal, Heiko Spallek, Joel White, Muhammad F. Walji

School of Dentistry Faculty Research and Publications

The overarching goal of the third scientific oral health symposium was to introduce the concept of a learning health system to the dental community and to identify and discuss cutting-edge research and strategies using data for improving the quality of dental care and patient safety. Conference participants included clinically active dentists, dental researchers, quality improvement experts, informaticians, insurers, EHR vendors/developers, and members of dental professional organizations and dental service organizations. This report summarizes the main outputs of the third annual OpenWide conference held in Houston, Texas, on October 12, 2022, as an affiliated meeting of the American Dental Association (ADA) …

The Satb1-Mir22-Gba Axis Mediates Glucocerebroside Accumulation Inducing A Cellular Senescence-Like Phenotype In Dopaminergic Neurons, Jonathan Plessis-Belair, Tae Wan Kim, Jacqueline Martin, Jason Ni, Jordan A Pearson, Emily J Park, Roger B Sher, Lorenz Studer, Markus Riessland

Faculty, Staff and Students Publications

Idiopathic Parkinson's disease (PD) is characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta, which is associated with neuroinflammation and reactive gliosis. The underlying cause of PD and the concurrent neuroinflammation are not well understood. In this study, we utilize human and murine neuronal lines, stem cell-derived dopaminergic neurons, and mice to demonstrate that three previously identified genetic risk factors for PD, namely SATB1, MIR22HG, and GBA, are components of a single gene regulatory pathway. Our findings indicate that dysregulation of this pathway leads to the upregulation of glucocerebrosides (GluCer), which triggers a cellular senescence-like phenotype …

Data Stewardship In Ftld Research: Investigator And Research Participant Views, Jalayne J Arias, Ana M Tyler, Laura M Beskow, Maria C Carillo, Susan Dickinson, Jill Goldman, Mary A Majumder, Michelle M Mello, Heather M Snyder, Jennifer S Yokoyama

Center for Medical Ethics and Health Policy Staff Publications

Introduction: Federal policies and guidelines have expanded the return of individual results to participants and expectations for data sharing between investigators and through repositories. Here, we report investigators' and study participants' views and experiences with data stewardship practices within frontotemporal lobal degeneration (FTLD) research, which reveal unique ethical challenges.

Methods: Semi-structured interviews with (1) investigators conducting FTLD research that includes genetic data collection and/or analysis and (2) participants enrolled in a single site longitudinal FTLD study.

Results: Analysis of the interviews identified three meta themes: perspectives on data sharing, experiences with enrollment and participation, and data management and security as …

Optimizing Single T-Cell Transcriptomic Discrimination Of Atopic Dermatitis Versus Psoriasis Vulgaris, Mark A Taylor, Abdullah El Kurdi, Ashley Hailer, Sijia Wang, Michelle Yuan, Sumanta Mukhopadhyay, Tina Bhutani, Jeffrey P North, Raymond J Cho, Jeffrey B Cheng

Staff and Researcher Publications

No abstract provided.

European Society Of Coloproctology Guideline On Training In Robotic Colorectal Surgery (2024), Samson Tou, Stephanie Au, Cillian Clancy, Steven Clarke, Danielle Collins, Frances Dixon, Elizabeth Dreher, Christina Fleming, Anthony G Gallagher, Marcos Gomez-Ruiz, Jos Kleijnen, Yasuko Maeda, Katie Rollins, Klaus E Matzel

Staff and Researcher Publications

No abstract provided.

Virtual Multi-Institutional Tumor Board: A Strategy For Personalized Diagnoses And Management Of Rare Cns Tumors, Lisa Boris, Yeonju Kim, Kenneth Aldape, Martha M Quezado, John A Butman, James G Smirniotopoulos, Huma Chaudhry, Christina I Tsien, Prashant Chittiboina, Kareem Zaghloul, Orwa Aboud, Nicholas G Avgeropoulos, Eric C Burton, David M Cachia, Karan S Dixit, Jan Drappatz, Erin M Dunbar, Peter Forsyth, Edina Komlodi-Pasztor, Jacob Mandel, Byram H Ozer, Eudocia Q Lee, Surabhi Ranjan, Rimas V Lukas, Margarita Raygada, Michael E Salacz, Matthew A Smith-Cohn, James Snyder, Ariane Soldatos, Brett J Theeler, Brigitte C Widemann, Kevin A Camphausen, John D Heiss, Terri S Armstrong, Mark R Gilbert, Marta Penas-Prado

Faculty, Staff and Students Publications

PURPOSE: Multidisciplinary tumor boards (MTBs) integrate clinical, molecular, and radiological information and facilitate coordination of neuro-oncology care. During the COVID-19 pandemic, our MTB transitioned to a virtual and multi-institutional format. We hypothesized that this expansion would allow expert review of challenging neuro-oncology cases and contribute to the care of patients with limited access to specialized centers.

METHODS: We retrospectively reviewed records from virtual MTBs held between 04/2020-03/2021. Data collected included measures of potential clinical impact, including referrals to observational or therapeutic studies, referrals for specialized neuropathology analysis, and whether molecular findings led to a change in diagnosis and/or guided management …

Icosapent Ethyl Following Acute Coronary Syndrome: The Reduce-It Trial, Eliot A Brinton, Terry A Jacobson, Steven B Ketchum, Lixia Jiao, Armando Lira Pineda, Ralph T Doyle, Jean Claude Tardif, Christie M Ballantyne, Ph Gabriel Steg

Faculty, Staff and Students Publications

No abstract provided.

A Scoping Review Of Artificial Intelligence In Medical Education: Beme Guide No 84, Hussein Uraiby, Nicole Y Xu, Rangana Bartlett, Janice Hanson, Mary Haas, Maxwell Spadafore, Ciaran Grafton-Clarke, Rayhan Yousef Gasiea, Colin Michie, Janet Corral, Brian Kwan, Diana Dolmans, Satid Thammasitboon

Faculty, Staff and Students Publications

Background: Artificial Intelligence (AI) is rapidly transforming healthcare, and there is a critical need for a nuanced understanding of how AI is reshaping teaching, learning, and educational practice in medical education. This review aimed to map the literature regarding AI applications in medical education, core areas of findings, potential candidates for formal systematic review and gaps for future research.

Methods: This rapid scoping review, conducted over 16 weeks, employed Arksey and O'Malley's framework and adhered to STORIES and BEME guidelines. A systematic and comprehensive search across PubMed/MEDLINE, EMBASE, and MedEdPublish was conducted without date or language restrictions. Publications included in …

Impact Of Insulin Sensitivity And Β-Cell Function Over Time On Glycemic Outcomes In The Glycemia Reduction Approaches In Diabetes: A Comparative Effectiveness Study (Grade): Differential Treatment Effects Of Dual Therapy, Ashok Balasubramanyam, Richard M Bergenstal, Joshua Barzilay, Cyrus Desouza, Ralph A Defronzo, Tom Elasy, Jonathan Krakoff, Steven E Kahn, Neda Rasouli, Willy M Valencia, William I Sivitz, Grade Research Group

Faculty, Staff and Students Publications

Objective: To compare the effects of insulin sensitivity and β-cell function over time on HbA1c and durability of glycemic control in response to dual therapy.

Research design and methods: GRADE participants were randomized to glimepiride (n = 1,254), liraglutide (n = 1,262), or sitagliptin (n = 1,268) added to baseline metformin and followed for mean ± SD 5.0 ± 1.3 years, with HbA1c assessed quarterly and oral glucose tolerance tests at baseline, 1, 3, and 5 years. We related time-varying insulin sensitivity (HOMA 2 of insulin sensitivity [HOMA2-%S]) and early (0-30 min) and total (0-120 min) C-peptide (CP) responses to …