Digital Commons Network^™

Spatial Ecology Of Mule Deer Migrations From Grand Teton National Park And The Teton Range, Justin K. Schwabedissen

All Graduate Theses and Dissertations, Fall 2023 to Present

The Greater Yellowstone Ecosystem hosts several of the longest, fully intact ungulate migrations remaining in the continental United States. However, expanding development and an increasing human footprint continue to truncate migratory routes. While the endpoints are often a seasonal range on protected lands, these migration corridors frequently cross other jurisdictional boundaries, including large tracts of private or multiple-use lands, with varying levels of protection. Thus, it is critical resource managers understand the dynamics of migratory movements to define population-level corridors and prioritize appropriate conservation strategies. Mule deer in Wyoming have been documented traveling long distances between summer and winter ranges; …

The Influence Of Individual Strategies On Cougar Ecology: Insights From Predation, Space Use, And Reproduction, Kristin Nicole Engebretsen

All Graduate Theses and Dissertations, Fall 2023 to Present

Carnivores are ecologically important to global ecosystems because they interact with their prey species and other carnivores in a variety of ways. Many carnivores have suffered habitat loss and persecution by humans, which has led some populations to become imperiled or locally extirpated. Despite these challenges, cougars (Puma concolor) continue to exist across North, Central, and South America. They exhibit behavioral adaptation across their wide range, thriving in terrain that ranges from temperate forests, to steppe scrub, to rainforest, to rugged deserts. Across these diverse ecosystems, cougars can successfully establish territories, hunt prey, and raise young to persist …

Morphological And Physio-Biochemical Responses And Gene Expression Analyses Of Landscape Plants Under Salinity Stress, Asmita Paudel

All Graduate Theses and Dissertations, Fall 2023 to Present

Soil salinity is a significant global issue that adversely impacts the growth and development of landscape plants. One of the effective strategies to prevent salinity damage to landscape plants is to cultivate species that are tolerant to the prevailing salinity levels. Salinity tolerance varies among plant species and cultivars. Therefore, this research aimed to investigate the salinity tolerance of nine landscape plants [Albizia julibrissin (mimosa tree), Arctostaphylos uva-ursi (kinnikinnick), Cercocarpus ledifolius (curl-leaf mountain mahogany), Cercocarpus montanus ‘Coy’ (alder-leaf mountain mahogany), Penstemon barbatus ‘Novapenblu’ (rock candy blue^® penstemon), Penstemon strictus ‘Rocky Mountain’ (rocky mountain beardtongue), Punica granatum ‘Wonderful’ (pomegranate), …

Systematic Review Of The Use Of Multiperson Activity Schedules For Individuals With Disabilities, Caili A. Johnson

All Graduate Theses and Dissertations, Fall 2023 to Present

Multiperson activity schedules capitalize on the benefits of independent activity schedules, a commonly used visual support for individuals with disabilities. Activity schedules minimize the need for adult prompting and increase independence with complex tasks by breaking them down into pictures, written words, or videos. Multiperson schedules allow pairs and small groups of individuals with disabilities to work together with minimal adult involvement to accomplish a task. This systematic review aims to inform researchers and other interested persons regarding the use of multiperson activity schedules to aid in decision-making and support implementation. We screened 146 articles and dissertations against our study …

Nutrient Management Of Cannabis In Controlled Environments, Julie A. Hershkowitz

All Graduate Theses and Dissertations, Fall 2023 to Present

Cannabis has been cultivated for millennia as a multipurpose crop for food, fiber, and medicine. Secondary metabolites called cannabinoids, including cannabidiol (CBD) and the psychoactive Δ-9 tetrahydrocannabinol (Δ-9 THC), are responsible for the medicinal properties of cannabis. The intoxicating nature of THC resulted in legislation prohibiting the possession and production of cannabis within the United States during the 20^th century. As a result, research programs on cannabis production were halted at most institutions. In recent years, cannabis production has become widespread within the US as a result of increasing legalization. However, modern cannabis production nutrient management programs often include …

Empowering Graphics: A Distributed Rendering Architecture For Inclusive Access To Modern Gpu Capabilities, Taylor Anderson

All Graduate Theses and Dissertations, Fall 2023 to Present

Modern rendering software requires powerful GPUs with the latest hardware features in order to utilize all of the newest rendering techniques. Many users do not have access to this hardware, and rely on remote server farms or reduced performance to achieve usable results. In this thesis, the software is designed and created to allow for a user to share the resources of their computer with another, modeling a split-screen setup like was common in the past, but without requiring users to be in the same location.

By designing the software from the ground up to support this, instead of adding …

Artificial Intelligence In Landscape Architecture: A Survey Of Theory, Culture, And Practice, Phillip J. Fernberg

All Graduate Theses and Dissertations, Fall 2023 to Present

This dissertation explores the role of artificial intelligence (AI) in shaping the landscape architecture profession. It looks at how AI has evolved in the field, its current influence, and its potential to change research, teaching, and professional practice. The research includes a detailed review of existing literature to identify trends in AI applications and gaps in knowledge. It also examines landscape architects' attitudes towards AI, revealing a mix of enthusiasm for its benefits and concerns about its impact on creativity and design processes, and proposes new ways of thinking about and working with AI. The work brings a unique perspective …

Techniques To Overcome Energy Storage Limitations In Electric Vehicles, Matthew J. Hansen

All Graduate Theses and Dissertations, Fall 2023 to Present

Electric vehicles are becoming increasingly popular, battery limitations (cost, size, and weight) complicate electric vehicle adoption. While important research on battery development is ongoing, this dissertation discusses two main approaches to overcome those limitations within the existing battery technology paradigm. Those thrusts are: improving battery health through an optimal charging strategy and minimizing necessary battery size through dynamic wireless power transfer. In this dissertation, relevant literature is discussed, with opportunities for further development considered. Within the two thrusts, three objectives sharpen the focus of the research presented here. First, a planning tool is defined for a battery electric bus fleet. …

Causes And Consequences Of Space-Use Behavior Under Predation Risk In A Free-Living System, Brian J. Smith

All Graduate Theses and Dissertations, Fall 2023 to Present

Predators can have important ecological effects through killing and eating their prey, the so-called consumptive effect, but predators can also have a nonconsumptive effect (NCE) on their prey – this happens when the risk of predation itself causes prey to alter their behaviors or other traits and these alterations ultimately reduce prey survival, reproduction, or population size. While scientists understand the consumptive effects of predators well, we are still unsure whether NCEs are important in free-living systems. In this dissertation, I sought to better understand the potential NCEs of predators (wolves and cougars) on elk in northern Yellowstone National Park …

Public Cyberattack Attribution And Domestic Political Considerations: An Analysis Of State Decision Making, Ella M. Devey

All Graduate Theses and Dissertations, Fall 2023 to Present

When a country is targeted with a cyberattack, what compels its government to publicly attribute the perpetrators of the attack rather than keep their attribution private? Cyberattacks are an increasingly utilized weapon of international conflict by governments, groups, and individuals. Following a cyberattack, the target of the attack may investigate the origin of the attack and may choose to share their findings with the public; alternatively, they may choose not to publicly share their findings.

While we know that forensic capabilities and international political factors contribute to the decision of governments to make public cyberattack attribution, domestic political circumstances may …

The Last Days Of Elder Mitchell, Jack Bylund

All Graduate Theses and Dissertations, Fall 2023 to Present

The Last Days of Elder Mitchell is a novella following the eponymous Latter-Day Saint missionary as he narrates the miracles performed by his colleague, Elder Gibson, as well as his personal grappling with his queer identity as he serves a high-demand religion that condemns people like him. The narrative explores the intersection of queerness and faith, the form of the novella, and the healing nature of autobiographical fiction.

Acoustic-Perceptual Relations Between Fundamental Frequency And Expressiveness In Speakers With Hypokinetic Dysarthria, Alena Portnova

All Graduate Theses and Dissertations, Fall 2023 to Present

Hypokinetic dysarthria is a motor speech disorder that occurs in patients with Parkinson’s disease (PD) and affects not only their speech intelligibility but also how their attitudes and emotions are perceived by listeners. People with PD have been judged as less happy, involved, friendly, and interested based only on their speech samples. A lack of speech expressiveness is one of the characteristics that is likely to be related to these negative listener judgments. Specifically, it has been suggested that a lack of fundamental frequency (F0) variation reduces speakers’ ability to express various emotions. To investigate whether speech expressiveness is related …

Processes For Improved Variable Rate Irrigation And Nitrogen Within Potato-Wheat-Wheat Cropping Systems, Elisa A. Flint

All Graduate Theses and Dissertations, Fall 2023 to Present

Proper irrigation and nutrient management are vital for optimal crop production within agricultural fields. Improving irrigation and nutrient application through precision agriculture is necessary to conserve the limited resources available, while improving yield and quality of crops produced through such a system. Variable rate irrigation (VRI) and variable rate nitrogen are systems used to apply water and nitrogen more precisely to agricultural fields to reduce runoff, deep percolation, leaching, and other negative impacts of over application, while providing the optimal rates to produce maximum yields. However, the processes to utilize these systems have proven to be more difficult than expected, …

Movement Behavior And Habitat Selection Of Juvenile Mountain Lions (Puma Concolor) During Three Behavioral States Of Dispersal, John F. Randolph

All Graduate Theses and Dissertations, Fall 2023 to Present

Juvenile dispersal, the act of moving from their natal range to the place where they eventually reproduce and establish an adult home range is hazardous. Juveniles must travel and find food across unfamiliar landscapes, where they must also cross roads, avoid harvest, and navigate developed landscapes. Despite the inherent dangers of dispersal, this demographic process is important for finding suitable mates and reducing inbreeding depression. Wildlife conservation concerns arise when individuals are unable to disperse due to a loss of connectivity, as this can negatively impact population demographics and genetic diversity. We explored the effects of hunting and human-developed landscapes …

An Expansive Framing Intervention And Its Influence On Nursing Students' Perceptions Of Value For Mathematics, Kimberly Evagelatos Beck

All Graduate Theses and Dissertations, Fall 2023 to Present

Nurses regularly use mathematics on the job, yet they often do not view their work as mathematical. This may indicate a lack of transfer from the nursing school mathematics context to nursing practice. Further, nursing students often perceive very little usefulness and relevance for learning mathematics beyond simple calculations. Expansive Framing (EF) is a theory and instructional technique that has been shown to foster transfer by establishing intercontextuality, or connections made between disparate contexts. This research explored whether creating intercontextuality created through broad framing also improved perceptions of mathematics value and transferability, and how intercontextuality functioned as the driver of …

The Association Between Prenatal Care And Postpartum Depression: Current State And Future Directions, Esther Adebayo-Abikoye

Electronic Theses and Dissertations

Background

Postpartum depression (PPD) is a major public health challenge and associated with poor maternal and infant health outcomes. Quality prenatal care decreases adverse outcomes in pregnancy and may reduce PPD risk factors. This study critically reviews the evidence about the role of prenatal care practices in reducing PPD prevalence across population groups and examines the association between prenatal care timing and counseling content with PPD prevalence.

Methods

A scoping review was completed across eight databases to synthesize evidence about prenatal care and PPD across different contextual settings. National data from the Pregnancy Risk Assessment Monitoring System (PRAMS) was used …

From Tidewater To Tennessee: The Structuring Influences Of Virginia Schemata In The Settlement Of East Tennessee, Slade Nakoff

Electronic Theses and Dissertations

For over two hundred years, historians have debated the historical importance of early Tennessee migrants in shaping the state’s history. These discussions center around North Carolina's impact compared to Virginia's. By shifting discourse to the retention of migrant mentalities, the overwhelming influence of Virginia emerges through the continuity of privilege and commodification schemata. This study employs an interdisciplinary methodological approach combining schema theory, memory studies, and material culture analysis to outline the retention of mentalities from Tidewater, Virginia, to East Tennessee during the early settlement period. By utilizing the case study of John Carter of Watauga (1728-1781), the research illustrates …

In A State Of Becoming, Benjamin Conley

Electronic Theses and Dissertations

The artist discusses his Master of Fine Arts exhibition titled, In a State of Becoming. The exhibition was on view at the Tipton Gallery in downtown Johnson City, TN from February 26 March 8, 2024. In a State of Becoming showcased three large scale paintings, five multimedia prints, two sculptural installations, and a video projection installation. Conley's thesis research and current artistic practice revolve around the interfaces, connections, and relationships of humans and animals. Conley explicitly uses language like "animal" to describe "non-human animals" in his work's context. The exhibited works focused primarily on how the artist and/or the viewer …

Resonant Perceptions: Exploring Autistic Aesthetics Through Embodied Cognition, James Hutson, Piper Hutson

Faculty Scholarship

No abstract provided.

Ethical Imperatives And Challenges: Review Of The Use Of Machine Learning For Predictive Analytics In Higher Education, Emily Barnes, James Hutson, Karriem Perry

Faculty Scholarship

The escalating integration of machine learning (ML) in higher education necessitates a critical examination of its ethical implications. This article conducts a comprehensive review of the application of ML for predictive analytics within higher education institutions (HEIs), emphasizing the technology's potential to enhance student outcomes and operational efficiency. The study identifies significant ethical concerns, such as data privacy, informed consent, transparency, and accountability, that arise from the use of ML. Through a detailed analysis of current practices, this review underscores the need for HEIs to develop robust ethical frameworks and technological infrastructures to navigate these challenges effectively. The findings reveal …

Water Quality Hotspot Analysis On Chlorophyll-A To Monitor Harmful Algal Blooms In Small And Medium Lakes Of North Dakota, Sae Young Lee

Theses and Dissertations

The water quality of recreational lakes degrades with Harmful Algal Blooms (HABs). HABs can block sunlight, lower oxygen levels, and may produce toxins. Industrial and domestic waste and fertilizer runoffs can enrich nutrients for HABs. Chlorophyll-a (Chl-a) is a significant indicator for tracking HABs and has been monitored increasingly using remote sensing techniques. In search for significant trends in hotspots of Chl-a concentrations in small and medium lakes of northeastern North Dakota, Chl-a water samples were collected in summer and fall of 2023. The study lakes include: Fordville Dam Recreation Area, Larimore Dam RecreationArea, Homme Dam Recreation Area, and South …

Application Of Digital Holographic Imaging To Monitor Real-Time Cardiomyocyte Hypertrophy Dynamics In Response To Norepinephrine Stimulation, Wahida Akter, Herman Huang, Jacquelyn Simmons, Alexander Y. Payumo

Faculty Research, Scholarly, and Creative Activity

Cardiomyocyte hypertrophy, characterized by an increase in cell size, is associated with various cardiovascular diseases driven by factors including hypertension, myocardial infarction, and valve dysfunction. In vitro primary cardiomyocyte culture models have yielded numerous insights into the intrinsic and extrinsic mechanisms driving hypertrophic growth. However, due to limitations in current approaches, the dynamics of cardiomyocyte hypertrophic responses remain poorly characterized. In this study, we evaluate the application of the Holomonitor M4 digital holographic imaging microscope to track dynamic changes in cardiomyocyte surface area and volume in response to norepinephrine treatment, a model hypertrophic stimulus. The Holomonitor M4 permits non-invasive, label-free …

Targeting C-Myc Transactivation By Lmna Inhibits Trna Processing Essential For Malate-Aspartate Shuttle And Tumour Progression, Jianqun Wang, Mei Hong, Yang Cheng, Xiaojing Wang, Dan Li, Guo Chen, Banghe Bao, Jiyu Song, Xinyi Du, Chunhui Yang, Liduan Zheng, Qiangsong Tong

Faculty, Staff and Students Publications

Background: A series of studies have demonstrated the emerging involvement of transfer RNA (tRNA) processing during the progression of tumours. Nevertheless, the roles and regulating mechanisms of tRNA processing genes in neuroblastoma (NB), the prevalent malignant tumour outside the brain in children, are yet unknown.

Methods: Analysis of multi-omics results was conducted to identify crucial regulators of downstream tRNA processing genes. Co-immunoprecipitation and mass spectrometry methods were utilised to measure interaction between proteins. The impact of transcriptional regulators on expression of downstream genes was measured by dual-luciferase reporter, chromatin immunoprecipitation, western blotting and real-time quantitative reverse transcription-polymerase chain reaction (RT-PCR) …

Validation Of Single-Nucleotide Mosaic Variants Through Droplet Digital Pcr, Christopher M Grochowski, Richard A Gibbs, Harsha Doddapaneni

Faculty, Staff and Students Publications

The detection, validation, and subsequent interpretation of potentially mosaic single-nucleotide variants (SNV) within next-generation sequencing data remains a challenge in both research and clinical laboratory settings. The ability to identify mosaic variants in high genome coverage sequencing data at levels of 1% or lower underscores the necessity for developing guidelines and best practices to verify these variants orthogonally. Droplet digital PCR (ddPCR) has proven to be a powerful and precise method that allows for the determination of low-level variant fractions within a given sample. Herein we describe two precise ddPCR methods using either a fluorescent TaqMan hydrolysis probe approach or …

Clinical, Radiological And Molecular Responses To Combination Chemotherapy With Mapk Pathway Inhibition In Relapsed And Refractory Langerhans Cell Histiocytosis, Vivekanudeep Karri, Howard Lin, Jessica Velazquez, Akanksha Batajoo, Deevyashali Parekh, Whitney Stanton, Harshal Abhyankar, Nader K El-Mallawany, Jennifer Agrusa, Olive Eckstein, Nitya Gulati, Jeffrey Schwartz, Wendy Woods-Swafford, Jaime Boyd, Anikit Saha, Carl E Allen, Kenneth L Mcclain

Faculty, Staff and Students Publications

Optimal therapeutic approaches for advanced Langerhans cell histiocytosis (LCH) are not known. We assessed the safety and efficacy of combined chemotherapy with MAPK pathway inhibition in 10 patients with refractory systemic disease and/or LCH-associated neurodegeneration. Overall response rate was 9/10 (90%) for the entire cohort: 5/5 (100%) for patients with systemic disease and 6/7 (86%) for patients with central nervous system disease. BRAFV600E+ peripheral blood fraction decreased in 5/6 (83%). Toxicities included fever, skin rash, myalgias, neuropathy, cytopenias and hypocalcaemia. Prospective trials are required to optimize combination strategies, determine potential to achieve cure and compare outcomes to chemotherapy or MAPK …

The Submerged Administrative State, Gabriel Scheffler, Daniel E. Walters

Faculty Scholarship

The United States government is experiencing a reputation crisis: after decades of declining public trust, many Americans have lost confidence in the government’s capacity to perform its basic functions. While various explanations have been offered for this worrying trend, these existing accounts overlook a key factor: people are unfamiliar with the institutions that actually do most of the governing—administrative agencies—and they devalue what they cannot easily observe. The “submerged” nature of the administrative state is, we argue, a central reason for declining trust in government.

This Article shows that the administrative state is systematically submerged in two ways. First, administrative …

Memo: Dataset And Methods For Robust Multimodal Retinal Image Registration With Large Or Small Vessel Density Differences, Chiao-Yi Wang, Faranguisse Kahki Sadrieh, Yi-Ting Shen, Shih-En Chen, Sarah Kim, Victoria Chen, Achyut Raghavendra, Dongyi Wang, Osamah Saeedi, Yang Tao

Biological and Agricultural Engineering Faculty Publications and Presentations

The measurement of retinal blood flow (RBF) in capillaries can provide a powerful biomarker for the early diagnosis and treatment of ocular diseases. However, no single modality can determine capillary flowrates with high precision. Combining erythrocyte-mediated angiography (EMA) with optical coherence tomography angiography (OCTA) has the potential to achieve this goal, as EMA can measure the absolute RBF of retinal microvasculature and OCTA can provide the structural images of capillaries. However, multimodal retinal image registration between these two modalities remains largely unexplored. To fill this gap, we establish MEMO, the first public multimodal EMA and OCTA retinal image dataset. …

Exposure To 4,4′-Dde In Visceral Adipose Tissue And Weight Loss In Adolescents From The Teen-Labs Cohort, Bruna Rubbo, Zhenjiang Li, Phum Tachachartvanich, Brittney O Baumert, Hongxu Wang, Shudi Pan, Sarah Rock, Justin R Ryder, Todd Jenkins, Stephanie Sisley, Xiangping Lin, Scott Bartell, Thomas H Inge, Stavra Xanthakos, Brooklynn Mcneil, Anna R Robuck, Michele A La Merrill, Douglas I Walker, David V Conti, Rob Mcconnell, Sandrah P Eckel, Lida Chatzi

Faculty, Staff and Students Publications

Objective: Dichlorodiphenyldichloroethylene (DDE), an obesogen accumulating in adipose tissue, is released into circulation with weight loss, although its impact is underexplored among adolescents. We tested the association using an integrative translational approach of epidemiological analysis among adolescents with obesity and in vitro measures exploring the impact of DDE on adipogenesis via preadipocytes.

Methods: We included 63 participants from the Teen-Longitudinal Assessment of Bariatric Surgery (Teen-LABS) cohort. We assessed 4,4'-DDE in visceral adipose tissue at surgery and BMI and waist circumference at surgery and 0.5, 1, 3, and 5 years after. We conducted longitudinal analysis to estimate the interaction on weight …

Proteomic Biomarkers Of Quantitative Interstitial Abnormalities In Copdgene And Cardia Lung Study, Bina Choi, Gabrielle Y Liu, Quanhu Sheng, Kaushik Amancherla, Andrew Perry, Xiaoning Huang, Ruben San José Estépar, Samuel Y Ash, Weihua Guan, David R Jacobs, Fernando J Martinez, Ivan O Rosas, Russell P Bowler, Jonathan A Kropski, Nicholas E Banovich, Sadiya S Khan, Raúl San José Estépar, Ravi Shah, Bharat Thyagarajan, Ravi Kalhan, George R Washko

Faculty, Staff and Students Publications

Rationale: Quantitative interstitial abnormalities (QIAs) are early measures of lung injury automatically detected on chest computed tomography scans. QIAs are associated with impaired respiratory health and share features with advanced lung diseases, but their biological underpinnings are not well understood. Objectives: To identify novel protein biomarkers of QIAs using high-throughput plasma proteomic panels within two multicenter cohorts.

Methods: We measured the plasma proteomics of 4,383 participants in an older, ever-smoker cohort (COPDGene [Genetic Epidemiology of Chronic Obstructive Pulmonary Disease]) and 2,925 participants in a younger population cohort (CARDIA [Coronary Artery Disease Risk in Young Adults]) using the SomaLogic SomaScan assays. …

Longitudinal Natural History Studies Based On Real-World Data In Rare Diseases: Opportunity And A Novel Approach, Laura Ann Adang, Anjana Sevagamoorthy, Omar Sherbini, Jamie L Fraser, Joshua L Bonkowsky, Francesco Gavazzi, Russel D'Aiello, Nicholson B Modesti, Emily Yu, Sylvia Mutua, Emma Kotes, Justine Shults, Ariel Vincent, Lisa T Emrick, Stephanie Keller, Keith P Van Haren, Sarah Woidill, Isabella Barcelos, Amy Pizzino, Johanna L Schmidt, Florian Eichler, Ali Fatemi, Adeline Vanderver

Faculty, Staff and Students Publications

Growing interest in therapeutic development for rare diseases necessitate a systematic approach to the collection and curation of natural history data that can be applied consistently across this group of heterogenous rare diseases. In this study, we discuss the challenges facing natural history studies for leukodystrophies and detail a novel standardized approach to creating a longitudinal natural history study using existing medical records.

Prospective studies are uniquely challenging for rare diseases. Delays in diagnosis and overall rarity limit the timely collection of natural history data. When feasible, prospective studies are often cross-sectional rather than longitudinal and are unlikely to capture …