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Becoming A Bilingual Teacher On The Border: Developing Ideological Clarity At A Hispanic-Serving Institution, Laura J. Salazar May 2024

Becoming A Bilingual Teacher On The Border: Developing Ideological Clarity At A Hispanic-Serving Institution, Laura J. Salazar

Open Access Theses & Dissertations

As teacher education programs encourage more candidates to pursue bilingual certification, a need exists to improve the ways that preservice teachers (PSTs) are prepared to teach in bilingual classrooms. Research suggests the importance of preparing PSTs in the area of linguistic ideological clarity. Scholars define ideological clarity as an ongoing process through which individuals can critically consider their ideological orientations as well as dominant ideologies that favor those in power, with an aim of becoming agents of change through this process (Alfaro & Bartolomé, 2017). This case study sought to understand the opportunities that bilingual PSTs have to develop ideological …


Bcl2 Mediated Targeted Drug Delivery For The Treatment Of Kidney Fibrosis And Stomach Cancer, Humayra Afrin May 2024

Bcl2 Mediated Targeted Drug Delivery For The Treatment Of Kidney Fibrosis And Stomach Cancer, Humayra Afrin

Open Access Theses & Dissertations

Apoptosis, the programmed death of cells, is primarily regulated by a delicate balance between pro-apoptotic and anti-apoptotic signals. The Bcl-2 (B-cell lymphoma 2) family of proteins acts as anti-apoptotic agents, promoting cell survival. Dysregulation of these proteins is a common occurrence in conditions such as cancer and fibrosis, where overexpression of anti-apoptotic members can foster tumor cell survival and fibroblast activation. In this study, our aim was to explore the therapeutic potential of Bcl-2 inhibitors, both as a small molecule (specifically Navitoclax (Navi)), inhibitor and as Bcl-2 siRNA, for targeted treatment. Intravenous administration of Navi often leads to thrombocytopenia, necessitating …


Dentistry And The Law: Taking Records When Leaving A Practice, Dan Schulte Jd May 2024

Dentistry And The Law: Taking Records When Leaving A Practice, Dan Schulte Jd

The Journal of the Michigan Dental Association

MDA Legal Counsel Dan Schulte advises on departing partner issues: without contracts, disputes arise regarding records, patient ownership, and practice buyout. Employment and shareholder agreements ensure orderly transitions and protect practice interests. Patient records legally belong to the practice, and transferring them without consent violates laws. Patients can request records, but fees apply. Schulte stresses the importance of agreements to avoid costly disputes and ensure continuity of care.


Targeted-Sequencing Evaluation For Fzd4 Variants In Familial Exudative Vitreo-Retinopathy, Mary Drekh, Wendy Dailey, Vincent Le, Savyo Krikor, Kimberly A. Drenser, Kenneth P. Mitton May 2024

Targeted-Sequencing Evaluation For Fzd4 Variants In Familial Exudative Vitreo-Retinopathy, Mary Drekh, Wendy Dailey, Vincent Le, Savyo Krikor, Kimberly A. Drenser, Kenneth P. Mitton

Posters

  • The Familial hereditary vision loss disease may present with symptoms including retinal detachment, folding, neovascularization, or vitreous hemorrhage due to peripheral retina avascularity.
  • The manifestation of FEVR genetically has been associated with a loss of function mutation of the Wnt/bcantenin-signaling pathway involving 7 genes (FZD4, NDP, CTNNB1, KIF11, LRP5, TSPAN12, and ZNF408). In our patient population of 72 individuals the distribution of FZD4 gene variants leading to FEVR has been recorded.
  • The Frizzled4 gene (FZD4) codes for the G-coupled protein receptor and effects Wnt/b-cantenin-signaling pathway In endothelial cells.
  • What frequency of FEVR from our patient pool will have FZD4 variants …


Supply Chain Management Internship – J.B. Hunt Transport Services, Inc., Garrett Locknar May 2024

Supply Chain Management Internship – J.B. Hunt Transport Services, Inc., Garrett Locknar

Supply Chain Management Undergraduate Honors Theses

The transportation industry touches every facet of business: research and development, final mile services, raw material procurement, even technology innovation and application design. Without transportation of goods, people, and services, each business as we know would fall apart. The greater supply chain itself relies heavily on the presence and precision of transportation to create value for each specific company’s operations. Beginning in the summer of 2022, I have had the privilege of interning at J.B. Hunt Transport, Inc., one of the world’s largest logistics and transportation companies, which has opened my eyes to the sheer impact of transportation on each …


Primary Care Employees' Knowledge And Self Efficacy About Human Trafficking, Mollie Zehmer May 2024

Primary Care Employees' Knowledge And Self Efficacy About Human Trafficking, Mollie Zehmer

Graduate Theses and Dissertations

Human trafficking is a worldwide issue that is detrimental to individuals, families, and communities. However, it is a hidden issue, and without proper training, it goes unnoticed. Many primary care employees do not know much about trafficking or how to identify trafficked persons, but with proper training they could potentially help clients that are trafficked persons. The purpose of this quasi-experimental study was to determine if human trafficking training would increase primary care employees’ knowledge and self-efficacy about human trafficking. The training included topics such as general knowledge, risk factors, identifiers, and the role of healthcare employees. Participants in the …


Exploring Peer Perspectives On Autistic Students: A Vignette Study, Justin Linville May 2024

Exploring Peer Perspectives On Autistic Students: A Vignette Study, Justin Linville

Electronic Theses and Dissertations

A 2x2 design was undertaken to determine the effects of vignette character gender and autism disclosure status on social distance scores, reading comprehension performance, and false memory induction. The introduction focuses on the theoretical threads taken from the autism, false memory, and gender literatures and how they combine to create the underpinning of the current design. A second more controlled study was compelled by initial false impressions of the deleterious effects of fast completion times. This second study resulted in lengthened completion times and improved vignette comprehension. Two-way MANOVAs with gender and autism disclosure serving as independent variables on the …


“‘With God For Us, We Must Be Successful’: Nationalism, Slavery, And Death In The Civil War Letters Of Robert Franklin Bunting”, Stuart James Priest May 2024

“‘With God For Us, We Must Be Successful’: Nationalism, Slavery, And Death In The Civil War Letters Of Robert Franklin Bunting”, Stuart James Priest

Electronic Theses and Dissertations

Robert Franklin Bunting (b. 1828, d. 1891) was a preeminent Presbyterian minister, church planter, and Confederate chaplain. Before serving as a chaplain, he planted multiple churches in Central Texas. As a chaplain, he wrote numerous letters to various Texas newspapers. This thesis utilizes Bunting’s letters to understand how white southerners understood and interacted with the primary social issues in the Civil War. Specifically, it examines how Bunting understood nationalism, slavery, and death. His perception of these issues flowed from his religious worldview. As such, it highlights his religious interplay with these issues and contributes to furthering our understanding of religion's …


Engaging Students In Learning Music Theory Fundamentals And Preparing For College Level Music Theory, Marissa Aronson May 2024

Engaging Students In Learning Music Theory Fundamentals And Preparing For College Level Music Theory, Marissa Aronson

Electronic Theses and Dissertations

The goal of this thesis is to provide teachers resources to prepare students for college-level music theory by using the keyboard. By providing visualization of patterns, the keyboard provides a superior tool to create a smooth transition between pre-college and college-level music theory instruction. In search of easing the passage between these levels, I interviewed numerous piano teachers who provided suggestions on how they include the keyboard to teach theory. After the interviews, I compared piano lesson theory books and college theory textbooks to compare their approaches. To assist with any gaps found in the theory books, I provide some …


Production And Heat Unit Accumulation Tracking Of Long-Cane Blackberry In Controlled Environments, Leala Machesney May 2024

Production And Heat Unit Accumulation Tracking Of Long-Cane Blackberry In Controlled Environments, Leala Machesney

Graduate Theses and Dissertations

Consumer demand for locally produced and high-quality blackberries is projected to increase. Most blackberry production is field-based, however, there is interest in producing blackberries using soilless culture and “long-cane” technique, where plants are grown in containers and trellised vertically. Soilless “long-cane” production of blackberries is viewed as a possible solution to the yield losses caused by soilborne pathogens such as Fusarium oxysporum, and methods of soil-borne pathogen control have become increasingly difficult with the ban of methyl bromide, a highly effective and widely used but environmentally harmful soil fumigant. Other reported benefits of soilless caneberry production include greater yields, increased …


Migration And Breeding Ecology Of King Rails (Rallus Elegans) In Southeast Arkansas, Jessica Schmit May 2024

Migration And Breeding Ecology Of King Rails (Rallus Elegans) In Southeast Arkansas, Jessica Schmit

Graduate Theses and Dissertations

King Rails (Rallus elegans) are a secretive marsh bird species of conservation concern in Arkansas. Freddie Black Choctaw West WMA in southeast Arkansas has multiple confirmed pairs of breeding King Rails and offered an opportunity to investigate King Rail migration ecology, as well as nesting ecology and nest site selection. In Chapter 1, we determined migratory status (resident vs. migratory) and described seasonal movement. To do this, we captured and outfitted 23 birds with Argos GPS tags to track migration patterns throughout the season. We found that most of the population did not make long distance migrations but instead were …


Developing Hispanic Pre-Service Elementary Bilingual Teachers’ Cultural Competence And Teacher Identity Through Mixed Reality Simulation, Yajaira A. Flores May 2024

Developing Hispanic Pre-Service Elementary Bilingual Teachers’ Cultural Competence And Teacher Identity Through Mixed Reality Simulation, Yajaira A. Flores

Theses and Dissertations

Due to the constant migration of diverse populations, multicultural communities are developing across North America. As a result, multi-culturally diverse classrooms are multiplying (Allen et al., 2017). Our pre-service teachers must be multi-culturally prepared to enter diverse classrooms and effectively teach students without implicit bias (Ladson-Billings, 1995; Banks, 2010; Paris, 2017). Pre-service teachers' identity and cultural competence should be prioritized in teacher preparation programs. Using Latino/a Critical Race Theory (LatCrit), Practice-Based Learning, and Teacher Identity as conceptual frameworks, this study will answer how Mixed Reality Simulation (MRS) may be used as a teacher preparation tool (Aguilar & Flores, 2022) to …


Integrating Collective Art Healing Practices Into Contemporary Art Therapy, Taleene Armen, Nicole Aviel, Ej Liao, Brianna Mitjans, Mandy Schuster May 2024

Integrating Collective Art Healing Practices Into Contemporary Art Therapy, Taleene Armen, Nicole Aviel, Ej Liao, Brianna Mitjans, Mandy Schuster

LMU Theses and Dissertations

Five graduate students from the Marital and Family Art Therapy Program at Loyola Marymount University (LMU) conducted a research study to explore the characteristics and attributes of collective art practices and how they contribute to healing. A survey including quantitative measures and qualitative responses were administered on the Qualtrics platform, allowing for a wide geographic reach and rapid data collection. The subsequent qualitative analysis involved the creation of visual artworks by the researchers, utilizing the arts as data to identify additional common themes contributing to healing attributes. The data revealed three major themes, or characteristics, of how art contributes to …


Data Supporting The Journal Manuscript: From Past Habitats To Present Threats: Tracing North American Weasel Distributions Through A Century Of Climate And Land Use Change, Amanda E. Cheeseman, David S. Jachowski, Roland Kay May 2024

Data Supporting The Journal Manuscript: From Past Habitats To Present Threats: Tracing North American Weasel Distributions Through A Century Of Climate And Land Use Change, Amanda E. Cheeseman, David S. Jachowski, Roland Kay

NRM Departmental Data Sets

The downloable zip file contains eight data files:

Mustela_nivalis.US.1940.1949
Mustela_nivalis.US.2010.2019
Mustela_richardsonii.US.1940.1949
Mustela_richardsonii.US.2010.2019
Neogale_frenata.US.1940.1949
Neogale_frenata.US.2010.2019

File size: 6.5MB
FileType: TIFF and CSV


Perceptions Of Applied Behavior Analysis Therapy On Children With Autism Spectrum Disorder Via Social Media, Kaitlyn Drilling May 2024

Perceptions Of Applied Behavior Analysis Therapy On Children With Autism Spectrum Disorder Via Social Media, Kaitlyn Drilling

Honors Thesis

The use of Applied Behavioral Analysis Therapy (ABA) on children with Autism Spectrum Disorder (ASD) is a controversial topic. Stakeholders have strong opinions, and the use of social media allows them to reach a bigger audience to share their perceptions. Stakeholders such as parents of children with ASD, adults with ASD who have been treated using ABA therapy, and ABA clinicians themselves may post on long-form social media such as Reddit or Facebook to ASD specific forums. These forums provide stakeholders with information, community, and support that they might not have otherwise. The perceptions of ABA on children with ASD …


Comparing The Regulatory Effects Of Overexpressed Micrornas And Xenobiotic Drugs On Cell Cycle And Apoptotic Regulators In Pc-3 Cells, Tommie Johnson May 2024

Comparing The Regulatory Effects Of Overexpressed Micrornas And Xenobiotic Drugs On Cell Cycle And Apoptotic Regulators In Pc-3 Cells, Tommie Johnson

Dissertations (2016-Present)

MicroRNA was first discovered in C. elegans as small temporal RNA (stRNA) that does not code for protein. Since being discovered they have played a significant role in regulating gene expression at the post-transcriptional level. miRNAs are found in various organisms, and they bind to the 3' untranslated regions to inhibit translation and cause mRNA degradation. Some drugs are involved in cell cycle regulation such as Palbociclib, Ribociclib (LEE011), and Abemaciclib (LY2835219), that causes G1 arrest impeding cell proliferation. Cyclin D1 (CCND1) is supported by the cell cycle making it into a functional product. When undergoing a chemical reaction, the …


A Randomized Controlled Study Of The Effects Of Targeted Health Education On Uptake Of Contraceptives Among Women Of Reproductive Age In Nnewi City, South-East Nigeria, Yanmeer Tyotswam, Rosebella Iseme-Ondiek, Eliphas Makunyi May 2024

A Randomized Controlled Study Of The Effects Of Targeted Health Education On Uptake Of Contraceptives Among Women Of Reproductive Age In Nnewi City, South-East Nigeria, Yanmeer Tyotswam, Rosebella Iseme-Ondiek, Eliphas Makunyi

Population Health, East Africa

Objective: There is a need for contraception uptake among people to enable them to fulfil their right to determine the timing, number and spacing of their children. In regions with poor contraceptive prevalence rates, lack of effective education has been largely implicated, and Nigeria falls among such regions. Thus, the present study is designed to examine the impact of an educational intervention on uptake of contraceptives among women aged 18–49 years seeking care at the Nnamdi Azikiwe University Teaching Hospital Nnewi.

Methods: Being an interventional study to underscore the effect of targeted health education on uptake of contraceptives, …


Better Gait Quality And Speed In Adults With Down Syndrome When Wearing Supportive Shoes Compared To Unsupportive Shoes And Barefoot, Bailey Gosse, Kimberly Nguyen, Zoe Zelensky May 2024

Better Gait Quality And Speed In Adults With Down Syndrome When Wearing Supportive Shoes Compared To Unsupportive Shoes And Barefoot, Bailey Gosse, Kimberly Nguyen, Zoe Zelensky

UNLV Theses, Dissertations, Professional Papers, and Capstones

Background: Individuals with Down syndrome (DS), often experience a slower gait speed and decreased quality of gait. Different types of footwear have shown changes in gait in people without DS. The current study aimed to examine the differences between wearing commercially available supportive shoes, unsupportive shoes, and no footwear on gait quality and speed in people with DS.

Methods: In this repeated measures study, 20 adults with DS walked under three footwear conditions: supportive, unsupportive, and no footwear. Gait deviations were scored according to the Rancho Los Amigos Observational Gait Analysis (OGA) and gait speed was measured using the 10-Meter …


Development And Pilot Testing Of A Surface Discrimination Test For People With Lower Limb Amputation, Colin Kruger, Kyle Mcknight, Sharlene Lim, Samuel Straus May 2024

Development And Pilot Testing Of A Surface Discrimination Test For People With Lower Limb Amputation, Colin Kruger, Kyle Mcknight, Sharlene Lim, Samuel Straus

UNLV Theses, Dissertations, Professional Papers, and Capstones

Introduction: There is a lack of understanding as to how sensory loss and sensory deficits impact those with LLA. The purpose of this research is to determine the extent to which people with LLA can discriminate between surfaces underfoot, in order to better understand the relationship between people with LLA and their perception of the ground they are walking on. We developed a test to determine which qualities of surfaces may be easier to distinguish.

Methods: 10 unimpaired adults and 2 adults with LLA participated. Participants compared surfaces underfoot that consisted of ceramic, rough tile, gravel, sand, and sandpaper to …


Discerning Moral Injury, Alexandra A. Merletti May 2024

Discerning Moral Injury, Alexandra A. Merletti

UNLV Theses, Dissertations, Professional Papers, and Capstones

Moral injury is a recently developed psychological construct used to explain trauma that cannot be adequately explained by post-traumatic stress disorder (PTSD). It arises from experiences in which sufferers feel that they have violated deeply held moral beliefs and has multiple negative long term health and professional consequences for individuals affected. In order to better understand moral injury, this study seeks to understand how it is identified in individuals by others and utilizes Christie’s (2018) Ideal Victim Theory and Gray and Wegner’s (2009) Moral Typecasting Theory as a theoretical framework. Participants for this study were 374 undergraduate students at the …


An Interview With Kristen Gentry, Jess Marinaro May 2024

An Interview With Kristen Gentry, Jess Marinaro

Gandy Dancer Archives

No abstract provided.


Gandy Dancer 12.2, Gandy Dancer May 2024

Gandy Dancer 12.2, Gandy Dancer

Gandy Dancer Archives

Gandy Dancer is a literary magazine, publishing fiction, poetry, creative nonfiction, and visual art. We invite submissions from student writers and artists at all of the SUNY campuses. Edited by students at SUNY Geneseo, Gandy Dancer is published twice yearly. For more information, visit www.gandydancer.org. Gandy Dancer 12.2 is the twenty-third issue, published Spring 2024.


Lincoln's Carnegie Library: A History Of Community And Philanthropy, Emily Blomstedt May 2024

Lincoln's Carnegie Library: A History Of Community And Philanthropy, Emily Blomstedt

Honors Program: Senior Projects (Public)

Nebraska received 69 Carnegie libraries from the Carnegie foundation between 1899 and 1922. The first and most expensive Nebraska Carnegie library was granted to Lincoln in December 1899, after a fire destroyed Lincoln’s previous library. Lincoln’s main Carnegie library served the community between 1902 and 1960 before it was torn down in 1961 to build the present-day Bennett Martin library. This thesis explores the 60-year history of Lincoln’s Carnegie library, how it connects to national trends surrounding Carnegie libraries, and the role community and philanthropy played in the development of Lincoln’s public library system. These themes are examined through a …


Implementation And Effectiveness Of Stress Management Strategies Among Stem Students At The University Of Nebraska-Lincoln, Dylan Hiser May 2024

Implementation And Effectiveness Of Stress Management Strategies Among Stem Students At The University Of Nebraska-Lincoln, Dylan Hiser

Honors Program: Senior Projects (Public)

High-stakes exams often induce significant stress among STEM (Science, Technology, Engineering, and Math) students, impacting their academic performance and overall well-being. As the opportunity for careers in STEM grows rapidly, understanding the stressors that students face remains critical in mitigating the effects of this stress and ensuring the success of these students. The objective of this study is to determine how well STEM students respond to recommended interventions that mitigate exam stress and to identify trends in these students’ exam scores. To accomplish this, a set of surveys was sent to undergraduate STEM students at the University of Nebraska-Lincoln. The …


Target Strategic Audit, Ashley Mcrae May 2024

Target Strategic Audit, Ashley Mcrae

Honors Program: Senior Projects (Public)

Target is a prominent American retail chain known for its wide array of affordable yet stylish products. The company has built a strong reputation over several decades for its commitment to offering exclusive brands and unique shopping experiences to its diverse customer base. This strategic audit specifically focuses on the dynamic mass-market retail industry and analyzes Target’s ability to achieve a sustainable competitive advantage in an evolving industry. This report will specifically focus on an overview of the company and its operations, analysis of the competitive advantage Target possesses, and an examination of the strategy Target utilizes. Tools, like Porter’s …


Association Of Cardiovascular Health With Subclinical Coronary Atherosclerosis Progression Among Five Racial And Ethnic Groups: The Masala And Mesa Studies, Vardhmaan Jain, Mahmoud Al Rifai, Alka M Kanaya, Nilay S Shah, Sameera A Talegawkar, Salim S Virani, Erin D Michos, Roger S Blumenthal, Jaideep Patel May 2024

Association Of Cardiovascular Health With Subclinical Coronary Atherosclerosis Progression Among Five Racial And Ethnic Groups: The Masala And Mesa Studies, Vardhmaan Jain, Mahmoud Al Rifai, Alka M Kanaya, Nilay S Shah, Sameera A Talegawkar, Salim S Virani, Erin D Michos, Roger S Blumenthal, Jaideep Patel

Faculty, Staff and Students Publications

Background and aims: South Asian adults (SA) are at higher risk for atherosclerotic cardiovascular disease (ASCVD) compared with other racial/ethnic groups. Life's Simple 7 (LS7) is a guideline-recommended, cardiovascular health (CVH) construct to guide optimization of cardiovascular risk factors. We sought to assess if the LS7 metrics predict coronary artery calcium (CAC) incidence and progression in asymptomatic SA compared with four other racial/ethnic groups.

Methods: We assessed the distribution of CVH metrics (inadequate: score 0-8, average: 9-10, optimal: 11-14, and per 1-unit higher score) and its association with incidence and progression of CAC among South Asians in the Mediators of …


Social Determinants Of Health And Risk Of Stillbirth In The United States, April Adams, Deepa Dongarwar, Lena Shay, Mariana Baroni, Eunique Williams, Priscilla Ehieze, Rhanna Wilson, Alexia Awoseyi, Hamisu M Salihu May 2024

Social Determinants Of Health And Risk Of Stillbirth In The United States, April Adams, Deepa Dongarwar, Lena Shay, Mariana Baroni, Eunique Williams, Priscilla Ehieze, Rhanna Wilson, Alexia Awoseyi, Hamisu M Salihu

Faculty, Staff and Students Publications

Objective: Our aim was to evaluate the impact of social determinants of health (SDoH) risk factors on stillbirth among pregnancy-related hospitalizations in the United States.

Study design: We conducted a cross-sectional analysis of delivery-related hospital discharges using annualized data (2016-2017) from the Healthcare Cost and Utilization Project's Nationwide Inpatient Sample. The International Classification of Diseases, 10th Revision ICD-10-CM codes were used to select women with singleton stillbirth. Z-codes were utilized to identify SDoH risk factors and their subtypes. The association between SDoH risk factors and stillbirth was assessed using survey logistic regression models.

Results: We analyzed 8,148,646 hospitalizations, out of …


Immune Cell Pair Ratio Captured By Imaging Mass Cytometry Has Superior Predictive Value For Prognosis Of Non-Small Cell Lung Cancer Than Cell Fraction And Density, Jian-Rong Li, Chao Cheng May 2024

Immune Cell Pair Ratio Captured By Imaging Mass Cytometry Has Superior Predictive Value For Prognosis Of Non-Small Cell Lung Cancer Than Cell Fraction And Density, Jian-Rong Li, Chao Cheng

Faculty, Staff and Students Publications

No abstract provided.


Prospects For Leveraging The Microbiota As Medicine For Hypertension, David J Durgan, Jasenka Zubcevic, Matam Vijay-Kumar, Tao Yang, Ishan Manandhar, Sachin Aryal, Rikeish R Muralitharan, Hong-Bao Li, Ying Li, Justine M Abais-Battad, Jennifer L Pluznick, Dominik N Muller, Francine Z Marques, Bina Joe May 2024

Prospects For Leveraging The Microbiota As Medicine For Hypertension, David J Durgan, Jasenka Zubcevic, Matam Vijay-Kumar, Tao Yang, Ishan Manandhar, Sachin Aryal, Rikeish R Muralitharan, Hong-Bao Li, Ying Li, Justine M Abais-Battad, Jennifer L Pluznick, Dominik N Muller, Francine Z Marques, Bina Joe

Faculty, Staff and Students Publications

No abstract provided.


Mechanisms Driving Fasting-Induced Protection From Genotoxic Injury In The Small Intestine, Kali Deans-Fielder, Timothy Wu, Thanh Nguyen, Sarah To, Yang-Zhe Huang, Steven J Bark, Jason C Mills, Noah F Shroyer May 2024

Mechanisms Driving Fasting-Induced Protection From Genotoxic Injury In The Small Intestine, Kali Deans-Fielder, Timothy Wu, Thanh Nguyen, Sarah To, Yang-Zhe Huang, Steven J Bark, Jason C Mills, Noah F Shroyer

Faculty, Staff and Students Publications

Genotoxic agents such as doxorubicin (DXR) can cause damage to the intestines that can be ameliorated by fasting. How fasting is protective and the optimal timing of fasting and refeeding remain unclear. Here, our analysis of fasting/refeeding-induced global intestinal transcriptional changes revealed metabolic shifts and implicated the cellular energetic hub mechanistic target of rapamycin complex 1 (mTORC1) in protecting from DXR-induced DNA damage. Our analysis of specific transcripts and proteins in intestinal tissue and tissue extracts showed that fasting followed by refeeding at the time of DXR administration reduced damage and caused a spike in mTORC1 activity. However, continued fasting …