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Mobile Transfer Assist (Mta) Device, Ashley Homuth, Garrett Schnack, Will Bruner, Jacob Flores Jun 2026

Mobile Transfer Assist (Mta) Device, Ashley Homuth, Garrett Schnack, Will Bruner, Jacob Flores

Mechanical Engineering

The Mobile Transfer Assist (MTA) device was developed to assist caregivers with seated-to-seated transfers while reducing physical strain. The device uses a manually operated hand winch and pulley system to raise a user into a semi-standing position, allowing safe transfer between locations. The final design emphasizes portability, affordability, ease of use, and user safety through a modular frame, transfer sling, knee supports, and locking caster wheels. A verification prototype was fabricated and tested, demonstrating successful operation and compliance with project requirements established by VTC Santa Maria.


Hydropower Collegiate Competition 2026, Andres R. Arreola, Sammy D. Taporco, Kathryn E. Tinney, Ahmer S. Dhillon Jun 2026

Hydropower Collegiate Competition 2026, Andres R. Arreola, Sammy D. Taporco, Kathryn E. Tinney, Ahmer S. Dhillon

Mechanical Engineering

The Hydropower Collegiate Competition (HCC) is sponsored by the Department of Energy’s (DOE) Water Power Technologies Office (WPTO) and is meant to offer university students an opportunity to solve complex hydropower challenges, build industry connections, explore career connections, and obtain a greater knowledge of hydropower’s potential in the United States. For this year’s competition, our team investigated a potential in-conduit hydropower site in California. Our work included creating a design package for a crossflow turbine related to our selected site and completing the community connections challenge. We also completed a siting and design report, community connections report, design and siting …


Process Improvement For Thermal Barrier Coating Masking Applications, Katherine Meezan, Aiden Senn, Saksham Giri, Katelyn Perez Jun 2026

Process Improvement For Thermal Barrier Coating Masking Applications, Katherine Meezan, Aiden Senn, Saksham Giri, Katelyn Perez

Mechanical Engineering

Solar Turbines, a gas turbine manufacturer, needs a more efficient method to prevent the application of a thermal barrier coating (TBC) to select areas of their combustion liners during manufacturing. Currently, the process is labor, material, and time intensive: reusable masking tools should increase the efficiency of the TBC process.

This project is sponsored in full by Solar Turbines, and is under the guidance and administration of three Solar Turbines engineers: Chris Noone, Rick Rogers, and Carson Roff. The project is mentored by Cal Poly senior design Coach, Rick Lasko. This project will be completed by a team of four …


Me3328 Combined Loading Beam Bending Lab, Alejandro Islas, Viswesh Vancheeswaran, Owen Spencer, Henry Andrews Jun 2026

Me3328 Combined Loading Beam Bending Lab, Alejandro Islas, Viswesh Vancheeswaran, Owen Spencer, Henry Andrews

Mechanical Engineering

Serving as a new laboratory experiment for ME 3328 (Design for Strength & Stiffness), strain gauges were adhered, wired, and calibrated on a cantilever beam lab apparatus capable of undergoing pure bending, pure torsion, and combined bending.


Determining K Clusters In K-Means Clustering With The Crab Algorithm, Jasmine Kristine S. Cabrera Jun 2026

Determining K Clusters In K-Means Clustering With The Crab Algorithm, Jasmine Kristine S. Cabrera

Master's Theses

Unsupervised clustering often faces the challenge of determining the correct number of clusters in the absence of a true target variable. Traditional methods such as the Elbow Method and the Silhouette Score can produce ambiguous results and rely on assumptions about cluster shape or separation. To address this, we created the Clustering Rivals and Buddies (CRAB) algorithm which evaluates clusters based on stability across multiple subsamples. CRAB uses pairwise classifications to identify points that consistently group together called “Buddies” and points that remain separated called “Rivals.” Applied with K-means, CRAB accurately recovers underlying cluster structures in both spherical and non-spherical …


Teaching Multi-Core Architecture: Design And Implementation Of A Cache-Coherent Cpu For Undergraduate Education, Isaac R. Lake Jun 2026

Teaching Multi-Core Architecture: Design And Implementation Of A Cache-Coherent Cpu For Undergraduate Education, Isaac R. Lake

Master's Theses

Modern computing has relied on multicore processors for high performance for nearly two decades, yet undergraduate computer engineering curricula often provide limited exposure to parallel hardware architectures and their design challenges. This thesis presents the design of CPE 433, a course that extends the pipelined and cached OTTER CPU developed in CPE 233 and CPE 333 into a multicore processor capable of running parallel workloads. The thesis documents the architectural changes required to adapt the verified single-core design into a multicore system, including MMIO-based interrupt support, a shared cache hierarchy with cache-coherence mechanisms, and clock-gated modules. It further presents a …


A History Of The Underground Comix Scene: The Seriousness Of An Unserious Genre, Harris Darcie Shugart Jun 2026

A History Of The Underground Comix Scene: The Seriousness Of An Unserious Genre, Harris Darcie Shugart

Master's Theses

The Underground Comix Scene of the 1960s and 1970s was born out of an age of censorship. The Comics Code Authority, a regulatory body created by the Comics Magazine Association of America in 1954, established guidelines requiring publishing houses to self-regulate following a recommendation from the United States Senate Subcommittee on Juvenile Delinquency in 1953. Comix with an X, for their X-rated nature, represent an emerging counter-culture in the latter half of the 1960s and the 1970s, with an epicenter of San Francisco. These comix and their artists were not interested in obtaining the looming ‘Seal of Approval’ from the …


Trust And Pre-Employment Background Checks When Onboarding And Maintaining Information Security And Cybersecurity Staff, Stanley Mierzwa Jun 2026

Trust And Pre-Employment Background Checks When Onboarding And Maintaining Information Security And Cybersecurity Staff, Stanley Mierzwa

Center for Cybersecurity

The realm of trust is broad and can include many facets that are difficult to capture and catalog. In relation to the work roles of information security and cybersecurity, the intersection of trust in human resource management is critical and an evolving area within most modern organizations, in almost any sector, and of any size. A foundational element of trust is fundamental to effective mission and work roles in information security and cybersecurity, as well as to every employee tasked with contributing to the security of an organization’s assets. This chapter will include sections on the role trust can and …


The Court Of Small Things, The Curse Of Legal Superstition: The Precipitous Decline Of Small Claims Court, Why It Matters, And What Can Be Done About It, Telia Mary U. Williams Jun 2026

The Court Of Small Things, The Curse Of Legal Superstition: The Precipitous Decline Of Small Claims Court, Why It Matters, And What Can Be Done About It, Telia Mary U. Williams

Nevada Law Journal

This Article addresses the precipitous decline of small claims courts in the United States and argues that their erosion is more than administrative; it is a democratic and constitutional crisis. Small claims courts were once the laboratories of everyday justice, where ordinary citizens could access law without lawyers, ritual, or mystery. The seemingly minor disputes of the small claims court illuminate the democratic soul of American law. Yet, over recent decades, filings have declined dramatically, and the locus of power has shifted from the poor to repeat-player institutional actors. This is in part due to what I call, “legal superstition,” …


University Of Nebraska At Omaha Division Of Biomechanics And Research Development Annual Report 2023-2025, Uno Biomechanics Jun 2026

University Of Nebraska At Omaha Division Of Biomechanics And Research Development Annual Report 2023-2025, Uno Biomechanics

Biomechanics Annual Report

This report contains:

A letter from the Director: Dr. Nick Stergiou

Highlights articles

Center for Cardiovascular Research in Biomechanics (CRiB) articles

The Center for Research in Human Movement Variability (MOVCENTR) articles

People of UNO Biomechanics

Student Centered articles

Education Initiative articles


Stock Market Analysis And Volatility Behavior During The Covid-19 Pandemic, Manoj Venkatachalaiah, Soon Leong Yeap, Salman Ahmed Lnu, Sangwhan Cha Jun 2026

Stock Market Analysis And Volatility Behavior During The Covid-19 Pandemic, Manoj Venkatachalaiah, Soon Leong Yeap, Salman Ahmed Lnu, Sangwhan Cha

Harrisburg University Other Works

This report outlines the structural design, cloud implementation, and analytical findings of a scalable Big Data architecture deployed on Google Cloud Platform (GCP). The primary objective is to investigate the macroeconomic and microeconomic disruption caused by the COVID-19 pandemic on global equities, focusing on two dominant digital business models: online retail/cloud computing (Amazon, Inc. - AMZN) and subscription-based digital streaming entertainment (Netflix, Inc. - NFLX). Through a serverless orchestration pipeline leveraging GCP Cloud Run, automated workflows fetched and blended high-velocity epidemiological metrics alongside daily financial asset layers. Data transformations and parallel analytical calculations were executed utilizing Apache Beam pipelines inside …


(R2133) Analysis Of A Bulk Queue With Balking, Adaptive Overloading Service, Multiple Vacation, Inspection And Rework, S. Karpagam, R. Lokesh Jun 2026

(R2133) Analysis Of A Bulk Queue With Balking, Adaptive Overloading Service, Multiple Vacation, Inspection And Rework, S. Karpagam, R. Lokesh

Applications and Applied Mathematics: An International Journal (AAM)

We consider a queueing system that utilizes a single server to manage product flow through bulk and overload service modes, depending on queue length. Balking occurs when the queue length reaches ‘N’. After completion of service, products undergo quality inspection, with defective products sent for rework based on specific probabilities. If the product is non-defective, the server continues processing until the queue length exceeds a certain threshold; beyond this point, the server is either routed back to bulk service or directed to an overload service. Also, the server goes into a vacation mode when the queue size is below a …


Rethinking Pakistan Studies: The Grounds Of Regional Knowledge After South Asia, Zoya Sameen Jun 2026

Rethinking Pakistan Studies: The Grounds Of Regional Knowledge After South Asia, Zoya Sameen

FAS Pakistan

This article rethinks Pakistan Studies as both a pedagogical project and a field of knowledge by examining the limits of history as a tool of legitimation. It argues that in the public sphere, history often serves to authorize the present, and shows how Pakistan Studies has historically operated within this framework. At the same time, the article suggests that this condition opens up another possibility: to understand history not as passive inheritance but as an active demand upon the present. Seen in this light, Pakistan Studies emerges not as a stable body of knowledge but as a series of shifting …


Seqra Developments: Amendments To Ease Housing Construction, Revised Regulations, New Cases, Michael B. Gerrard Jun 2026

Seqra Developments: Amendments To Ease Housing Construction, Revised Regulations, New Cases, Michael B. Gerrard

Faculty Scholarship

In the hopes of easing the housing shortage, on May 26 the New York Legislature passed and Governor Kathy Hochul signed a bill that will exempt many multifamily housing projects from the State Environmental Quality Review Act (SEQRA).

A month before, the New York State Department of Environmental Conservation (DEC) issued regulations on protecting disadvantaged communities, and took steps to require more discussion of climate impacts under SEQRA.


Reforming Funding To Better Defend Families: Holistic Preventive Legal Advocacy That Checks Cps Agency Power, Joshua Gupta-Kagan Jun 2026

Reforming Funding To Better Defend Families: Holistic Preventive Legal Advocacy That Checks Cps Agency Power, Joshua Gupta-Kagan

Faculty Scholarship

The federal government has provided funds to support legal representation of parents facing allegations of child neglect or abuse since 2019, across administrations of both parties. That funding illustrates the field’s recognition of parent defense’s importance to improving outcomes and reducing harms from the family regulation system, especially once CPS agencies file petitions against parents. Federal Title IV-E funding supports parent representation in those family court cases and for parents at risk of facing such cases. That funding has been an essential boon to parent representation and the benefits that flow from it. It is nonetheless time to take a …


Ilae-Yes Global Webinar Series: Integrating Clinical And Basic Science In Epilepsy Research, Cecilie G Nome, Parthvi Ravat, Fabrice Bartolomei, Marco De Curtis, Rossella Di Sapia, Marian Galovic, Maria Gogou, Lukas Imbach, Julia Jacobs, Katja Kobow, Alice D Lam, Christos Panagiotis Lisgaras, Elisa Micalizzi, Eleni Nikalexi, Jeffrey L Noebels, Jeanne T Paz, Avtar Singh Roopra, Sally Shaaban, Laurent Sheybani, Shobi Sivathamboo, Ana Suller Marti, Adam Williamson, Naoto Kuroda Jun 2026

Ilae-Yes Global Webinar Series: Integrating Clinical And Basic Science In Epilepsy Research, Cecilie G Nome, Parthvi Ravat, Fabrice Bartolomei, Marco De Curtis, Rossella Di Sapia, Marian Galovic, Maria Gogou, Lukas Imbach, Julia Jacobs, Katja Kobow, Alice D Lam, Christos Panagiotis Lisgaras, Elisa Micalizzi, Eleni Nikalexi, Jeffrey L Noebels, Jeanne T Paz, Avtar Singh Roopra, Sally Shaaban, Laurent Sheybani, Shobi Sivathamboo, Ana Suller Marti, Adam Williamson, Naoto Kuroda

Faculty, Staff and Students Publications

Bridging clinical and basic research is increasingly recognized as a priority in the epilepsy field, yet opportunities for integration remain limited by the time, space, and financial constraints of scientific meetings. To address this gap, the Research Task Force of the Young Epilepsy Section of the International League Against Epilepsy (ILAE-YES) organized a free global webinar series designed to promote translational dialogue and provide accessible research education for early-career clinicians, researchers, and physician-scientists. Based on a preliminary ILAE-YES community survey, eight topics of high interest were selected: (1) epigenetics, (2) EEG biomarkers, (3) ictogenesis, (4) thalamo-cortical network, (5) sudden unexpected …


Generation And Characterization Of Twist1 Acetyl-Mimic And Acetyl-Deficient Mouse Models, Mary Elmeniawi, Xiaobin Yu, Samuel Wen, Gunjan A Bhatia, Lan Liao, Jianming Xu, Walid D Fakhouri Jun 2026

Generation And Characterization Of Twist1 Acetyl-Mimic And Acetyl-Deficient Mouse Models, Mary Elmeniawi, Xiaobin Yu, Samuel Wen, Gunjan A Bhatia, Lan Liao, Jianming Xu, Walid D Fakhouri

Faculty, Staff and Students Publications

TWIST1 encodes a highly conserved basic helix–loop–helix transcription factor essential for embryonic development from Drosophila to humans. TWIST1 activity is regulated by post‐translational modifications, including phosphorylation during development and cancer metastasis. Recent cancer studies identified acetylation of lysines K73 and K76 as a novel regulatory modification that shifts TWIST1 from a repressive to an activating state during epithelial‐to‐mesenchymal transition (EMT). However, the developmental and in vivo functions of TWIST1 acetylation remain unknown. To investigate the physiological role, we generated the first acetyl‐deficient Twist1 K73,76R K73,76R and acetyl‐mimic Twist1 K73,76Q K73,76Q mouse models using CRISPR/Cas9‐mediated genome editing. Targeted sequencing confirmed substitutions, …


Whole Genome Sequencing Analysis Of Over 3500 Individuals Dementia-Free Over 85 Years Old, Gina M Peloso, Dongyu Wang, Sabrina M Abbruzzese, Joshua C Bis, Seung Hoan Choi, Alexa Beiser, Jan Bressler, Josée Dupuis, Alison E Fohner, Mohsen Ghanbari, Richard A Gibbs, Nancy Heard-Costa, M Arfan Ikram, Paul Lacaze, Quentin Le Grand, Oscar L Lopez, Thomas H Mosley, Moeen Riaz, Aïcha Soumaré, Amber Yaqub, Eric Boerwinkle, Bruce M Psaty, Myriam Fornage, Sudha Seshadri, Anita L Destefano Jun 2026

Whole Genome Sequencing Analysis Of Over 3500 Individuals Dementia-Free Over 85 Years Old, Gina M Peloso, Dongyu Wang, Sabrina M Abbruzzese, Joshua C Bis, Seung Hoan Choi, Alexa Beiser, Jan Bressler, Josée Dupuis, Alison E Fohner, Mohsen Ghanbari, Richard A Gibbs, Nancy Heard-Costa, M Arfan Ikram, Paul Lacaze, Quentin Le Grand, Oscar L Lopez, Thomas H Mosley, Moeen Riaz, Aïcha Soumaré, Amber Yaqub, Eric Boerwinkle, Bruce M Psaty, Myriam Fornage, Sudha Seshadri, Anita L Destefano

Faculty, Staff and Students Publications

BACKGROUND:

Identifying genetic variants conferring resilience to Alzheimer’s disease and related dementia (ADRD) may hold promise for developing therapeutics.

OBJECTIVE:

To determine genetic associations with being dementia-free at age 85 (DF85).

METHODS:

We examined genetic associations, using whole genome sequencing data, with DF85 in three Trans-Omics for Precision Medicine cohorts and the Alzheimer’s Disease Sequencing Project Phenotype Harmonization Consortium. We tested common variants individually and aggregation of rare (MAF≤1%) coding and non-coding variants in DF85 participants (n=3,657) against individuals who were not DF85 (n=20,010). We verified associations using a stricter control set who developed dementia before age 85 (n=5,552).

RESULTS: …


Functional Genomics Studies Of Psychiatric Disorders In Individuals Of Latin American Populations: A Scoping Review, Luz M Porras, Isabelle Rodríguez-Lausell, Gabriel Iglesias-Maldonado, Emily Val F Tuliao, Gabriela Martínez, Chelsey Leveque, Julian Tobon, Rachel Eloy, Sintia Belangero, Cynthia M Bulik, Camila M Loureiro, Carolina Muniz Carvalho, Vanessa Ota, Diego Luiz Rovaris, Eric A Storch, Eva Maria Trujillo-Chi Vacuan, Maria M Velasquez, Latin American Genomics Consortium, Marcos L Santoro, Humberto Nicolini, Elizabeth G Atkinson, Janitza L Montalvo-Ortiz, Paola Giusti-Rodríguez Jun 2026

Functional Genomics Studies Of Psychiatric Disorders In Individuals Of Latin American Populations: A Scoping Review, Luz M Porras, Isabelle Rodríguez-Lausell, Gabriel Iglesias-Maldonado, Emily Val F Tuliao, Gabriela Martínez, Chelsey Leveque, Julian Tobon, Rachel Eloy, Sintia Belangero, Cynthia M Bulik, Camila M Loureiro, Carolina Muniz Carvalho, Vanessa Ota, Diego Luiz Rovaris, Eric A Storch, Eva Maria Trujillo-Chi Vacuan, Maria M Velasquez, Latin American Genomics Consortium, Marcos L Santoro, Humberto Nicolini, Elizabeth G Atkinson, Janitza L Montalvo-Ortiz, Paola Giusti-Rodríguez

Faculty, Staff and Students Publications

Over the past 15 years, genetic studies of psychiatric disorders have provided important insight into the contribution of both common variants of small effect, as well as rare exonic and copy number variants with large effect sizes. Genome-wide association studies (GWAS) allow us to understand the intricate polygenicity characteristic of many psychiatric disorders. However, a considerable proportion of single nucleotide polymorphisms (SNPs) implicated in these disorders localize to the non-coding regions of the genome. Unraveling the molecular mechanisms that underlie the etiology of psychiatric illnesses requires integration using functional genomics approaches. Functional genomics methods are critical for developing a mechanistic …


Fetal Instability And Resuscitative Management During Fetal Intervention: A Retrospective, Descriptive Analysis Of 245 Fetal Cardiac And Spina Bifida Procedures, Claire A Naus, Betul Yilmaz Furtun, Jessian L Munoz, Rebecca M Johnson, Carolyn A Altman, Michael A Belfort, Luc Joyeux, Alice King, David G Mann, Shaine Morris, Athar M Qureshi, Magdalena Sanz Cortes, William E Whitehead, Caitlin D Sutton Jun 2026

Fetal Instability And Resuscitative Management During Fetal Intervention: A Retrospective, Descriptive Analysis Of 245 Fetal Cardiac And Spina Bifida Procedures, Claire A Naus, Betul Yilmaz Furtun, Jessian L Munoz, Rebecca M Johnson, Carolyn A Altman, Michael A Belfort, Luc Joyeux, Alice King, David G Mann, Shaine Morris, Athar M Qureshi, Magdalena Sanz Cortes, William E Whitehead, Caitlin D Sutton

Faculty, Staff and Students Publications

Objective: The heterogeneity of fetal surgery has led to variability in the nature and frequency of fetal instability. Understanding these differences is critical for optimizing management.

Methods: We reviewed all fetal atrial septal interventions (FASI) and fetoscopic myelomeningocele (fMMC) repairs with fetal instability performed at our institution between March 2012 and April 2025. We described and compared the frequency, timing, etiology, and management of fetal instability.

Results: During the study period, 28 unique patients underwent 35 FASI procedures, and 210 patients underwent fMMC repair. Fetal instability occurred in 51 of 245 cases (20.8%), with rates varying significantly by procedure type …


Hematologic Markers And Machine Learning In Predicting Placenta Accreta: A Case-Control Study, Michael D Jochum, Kelly D Albrecht, Yamely Mendez Martinez, Victoria Zhang, Sanmay Sarada, Brian Burnett, Christina C Reed, Karin A Fox, Amir A Shamshirsaz, Michael A Belfort, Jessian L Munoz, Hennie A Lombaard Jun 2026

Hematologic Markers And Machine Learning In Predicting Placenta Accreta: A Case-Control Study, Michael D Jochum, Kelly D Albrecht, Yamely Mendez Martinez, Victoria Zhang, Sanmay Sarada, Brian Burnett, Christina C Reed, Karin A Fox, Amir A Shamshirsaz, Michael A Belfort, Jessian L Munoz, Hennie A Lombaard

Faculty, Staff and Students Publications

Objective: This study aims to enhance antenatal detection of placenta accreta spectrum (PAS) and predict severe hemorrhage at delivery using machine learning by evaluating the association between antenatal hematologic index trends across trimesters, imaging markers, and patient history.

Methods: We retrospectively analyzed 2017-2023 data from a PAS referral center, including demographics, laboratory results, ultrasounds, and outcomes. Patients with confirmed PAS (cases) were compared to those with antenatal risk but no histopathologic evidence of PAS (controls). Statistical analyses and machine learning models were developed to predict PAS. We also used machine learning to predict severe hemorrhage (>1500 mL) in the …


Classification Of Gck-Mody In A Child With Mild Hyperglycemia And Islet Autoantibody Positivity: A Diagnostic Challenge, Aman N Yarlagadda, Maria J Redondo, Toni I Pollin, Mustafa Tosur, Colleen O Jodarski, Jennifer J Bell Jun 2026

Classification Of Gck-Mody In A Child With Mild Hyperglycemia And Islet Autoantibody Positivity: A Diagnostic Challenge, Aman N Yarlagadda, Maria J Redondo, Toni I Pollin, Mustafa Tosur, Colleen O Jodarski, Jennifer J Bell

Faculty, Staff and Students Publications

We report a 9-year-old female who presented with mild, persistent hyperglycemia, with hemoglobin A1c and oral glucose tolerance test results in the prediabetes range, relatively preserved C-peptide, and mildly positive glutamate decarboxylase 65 autoantibody levels. A strong family history of lean, noninsulin-dependent diabetes suggested a possible monogenic cause. Genetic testing with a 28-gene maturity-onset diabetes of the young (MODY) panel identified a heterozygous variant of uncertain significance in GCK (NM_000162.5:c.179C>T [p.Thr60Ile]). Following review by the ClinGen Monogenic Diabetes Variant Curation Expert Panel, the GCK variant was reclassified as pathogenic, confirming a diagnosis of glucokinase (GCK)-MODY/GCK-hyperglycemia, a stable …


Anterior Cutaneous Nerve Entrapment Syndrome From Glucagon-Like Peptide-1 Receptor Agonist Injection, Neha Singh, Elisa Chaparro, Jordan Michael Shapiro, Emanuel Narcis Husu Jun 2026

Anterior Cutaneous Nerve Entrapment Syndrome From Glucagon-Like Peptide-1 Receptor Agonist Injection, Neha Singh, Elisa Chaparro, Jordan Michael Shapiro, Emanuel Narcis Husu

Faculty, Staff and Students Publications

Anterior cutaneous nerve entrapment syndrome (ACNES) is an underdiagnosed cause of abdominal pain. We report the first documented ACNES case following subcutaneous administration of glucagon-like peptide-1 receptor agonist. A 44-year-old man developed focal, neuropathic abdominal pain coinciding with initiation of tirzepatide injections. Clinical examination confirmed ACNES diagnosis, and pain improved after relocating injections away from the abdomen and initiating multimodal pharmacotherapy. This case emphasizes the need to consider ACNES in patients endorsing focal abdominal pain with concurrent use of glucagon-like peptide-1 therapy and highlights injection site modification as a simple, effective management strategy while exercising self-restraint with respect to workup.


A Trans-Omics Gene-Smoking Interaction Study Of Lung Cancer Based On Consortium Data, Ning Xie, Xiaowen Xu, Yanru Wang, Aoxuan Wang, Xiang Wang, Xuan Wang, Mengsheng Zhao, Jiacheng Zhou, Yongyue Wei, Manel Esteller, Zhibin Hu, Hongbing Shen, Rayjean J Hung, Christopher I Amos, Yi Li, David C Christiani, Feng Chen, Yang Zhao, Ruyang Zhang Jun 2026

A Trans-Omics Gene-Smoking Interaction Study Of Lung Cancer Based On Consortium Data, Ning Xie, Xiaowen Xu, Yanru Wang, Aoxuan Wang, Xiang Wang, Xuan Wang, Mengsheng Zhao, Jiacheng Zhou, Yongyue Wei, Manel Esteller, Zhibin Hu, Hongbing Shen, Rayjean J Hung, Christopher I Amos, Yi Li, David C Christiani, Feng Chen, Yang Zhao, Ruyang Zhang

Faculty, Staff and Students Publications

Rationale: Genetically predicted molecular traits provide a cost-effective approach for identifying biomarkers and uncovering underlying biological mechanisms. We extended this framework to investigate gene-smoking interactions in lung cancer susceptibility.

Objectives: To identify trans-omics gene-smoking interactions affecting lung cancer risk and to assess how biomarkers modify effect of smoking.

Methods: We conducted the first trans-omics gene-smoking interaction study of lung cancer by integrating consortium-scale individual genotype data (27 737 cases vs 449 910 noncases) from the International Lung Cancer OncoArray Consortium (ILCCO-OncoArray), Transdisciplinary Research Into Cancer of the Lung (TRICL), Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO), and the …


Association Of Infection Frequency And Incident Clonal Hematopoiesis Of Indeterminant Potential, Ajibike Lapite, Vernon A Burk, James Decuir, Junichi Ishigami, Seyedmohammad Saadatagah, Pradeep Natarajan, Christie M Ballantyne, Elizabeth A Platz, Katherine Y King Jun 2026

Association Of Infection Frequency And Incident Clonal Hematopoiesis Of Indeterminant Potential, Ajibike Lapite, Vernon A Burk, James Decuir, Junichi Ishigami, Seyedmohammad Saadatagah, Pradeep Natarajan, Christie M Ballantyne, Elizabeth A Platz, Katherine Y King

Faculty, Staff and Students Publications

Clonal hematopoiesis of indeterminant potential (CHIP) is an age-related phenomenon associated with increased risk of hematologic malignancy. Preclinical studies have shown that infection is a driver of CHIP; clinical studies in people living with HIV suggest a relationship between chronic infection and CHIP, but the association between infection frequency and incident CHIP in the general population remains unknown. We leveraged the atherosclerosis risk in communities study to design a closed prospective cohort study. CHIP was determined based on whole-exome sequencing at 2 time points 20 years apart. Included were 3,367 individuals without cancer or CHIP at time 1 and without …


Use Of Plozasiran Across A Spectrum Of Hypertriglyceridemia: Long-Term Efficacy And Safety Data From The Open-Label Extension Period Of Shasta-2 And Muir Trials, Christie M Ballantyne, Alexis Baass, Robert S Rosenson, Robert A Hegele, Stephen J Nicholls, Szilard Vasas, Peter Clifton, Kathryn J Lucas, Denes Pall, Rong Zhou, Nicholas J Leeper, Jennifer Hellawell, Lalitha Aiyer, Gerald F Watts, Daniel Gaudet Jun 2026

Use Of Plozasiran Across A Spectrum Of Hypertriglyceridemia: Long-Term Efficacy And Safety Data From The Open-Label Extension Period Of Shasta-2 And Muir Trials, Christie M Ballantyne, Alexis Baass, Robert S Rosenson, Robert A Hegele, Stephen J Nicholls, Szilard Vasas, Peter Clifton, Kathryn J Lucas, Denes Pall, Rong Zhou, Nicholas J Leeper, Jennifer Hellawell, Lalitha Aiyer, Gerald F Watts, Daniel Gaudet

Faculty, Staff and Students Publications

Background: Plozasiran, a hepatocyte-targeted siRNA against apolipoprotein C-III, has demonstrated substantial reductions in triglycerides (TGs) and related atherogenic lipoproteins across a spectrum of hypertriglyceridemia (HTG), leading to its approval for familial chylomicronemia syndrome in the United States, and subsequently in Canada and China. Long-term data suggest maintenance of these effects beyond the blinded treatment periods, supporting further evaluation of plozasiran across a broad spectrum of HTG.

Methods: Safety and efficacy were assessed in this open-label extension (OLE) of two phase 2b, randomized, double-blind trials, SHASTA-2 (n = 229) including patients with severe HTG (TG >500 mg/dL) and MUIR ( …


Paid Employment And Ability To Work Among People Receiving Dialysis: A Systematic Review Of Qualitative Studies, Ao Zhang, Adam Martin, Karine Manera, Chandana Guha, Martin Howell, Patrizia Natale, Nicole Scholes-Robertson, Dharshana Sabanayagam, Adeera Levin, Wolfgang Winkelmayer, Kevin F Erickson, Germaine Wong, Allison Jaure, Anita Van Zwieten Jun 2026

Paid Employment And Ability To Work Among People Receiving Dialysis: A Systematic Review Of Qualitative Studies, Ao Zhang, Adam Martin, Karine Manera, Chandana Guha, Martin Howell, Patrizia Natale, Nicole Scholes-Robertson, Dharshana Sabanayagam, Adeera Levin, Wolfgang Winkelmayer, Kevin F Erickson, Germaine Wong, Allison Jaure, Anita Van Zwieten

Faculty, Staff and Students Publications

Rationale & objective: People receiving dialysis have reduced workforce participation, which can affect mental well-being and exacerbate the financial burden of dialysis. This study describes the experiences and perspectives of people receiving dialysis on employment and their ability to work.

Study design: Systematic review and thematic synthesis of qualitative studies.

Setting & study populations: Adults aged 16 years and over receiving dialysis.

Search strategy & sources: MEDLINE, Embase, and PsycINFO were searched to May 2025 for qualitative and mixed-methods studies that reported the perspectives of people receiving dialysis on employment or ability to work.

Data extraction: Text from results and …


The Soft Cluster Score As A Multifaceted Predictive Model For Postoperative Outcomes, Gwendolyn B Henry, Spoorthi Kamepalli, Carter J Burns, Jeremy Birkmire, George Cholankeril, Avegail Flores, John A Goss, Abbas Rana Jun 2026

The Soft Cluster Score As A Multifaceted Predictive Model For Postoperative Outcomes, Gwendolyn B Henry, Spoorthi Kamepalli, Carter J Burns, Jeremy Birkmire, George Cholankeril, Avegail Flores, John A Goss, Abbas Rana

Faculty, Staff and Students Publications

Background: Consideration of both donor and recipient factors at the time of an organ offer is crucial in achieving the most optimal outcome given the shortage of available donor organs and waitlist mortality risk. Our aim was to achieve a comprehensive risk assessment for liver transplant patients by creating a series of independent risk index equations for 6 distinct posttransplant endpoints in the transplant continuum of care.

Methods: The Survival Outcomes Following Liver Transplantation (SOFT) Cluster score includes risk indices for patient mortality at 90 d, 1 y, 3 y, and 5 y posttransplant, graft failure at 1 y after …


Mitf Gain-Of-Function Mutation In Metastatic Prostate Cancer: A Rare Finding With Potential Therapeutic Significance, Paul J Pecorin, Nyembezi Dhliwayo, Matthew Demetrious, Ludimila Cavalcante, Veronica Rodriguez-Bravo, Josep Domingo-Domenech, Thomas Westbrook Jun 2026

Mitf Gain-Of-Function Mutation In Metastatic Prostate Cancer: A Rare Finding With Potential Therapeutic Significance, Paul J Pecorin, Nyembezi Dhliwayo, Matthew Demetrious, Ludimila Cavalcante, Veronica Rodriguez-Bravo, Josep Domingo-Domenech, Thomas Westbrook

Faculty, Staff and Students Publications

Background: Prostate cancer is the most common non-cutaneous malignancy in men and remains a leading cause of cancer-related mortality, particularly in aggressive variants. These tumors are usually associated with alterations in TP53, RB1, and PTEN. The microphthalmia-associated transcription factor (MITF) has been implicated in several malignancies, but its role in prostate cancer is less defined.

Case: We report the first case of metastatic prostate adenocarcinoma harboring a gain-of-function MITF E318K mutation. The patient presented with high tumor burden, rapid progression, and evidence of tumor heterogeneity. The E318K mutation, previously linked to melanoma and renal cell carcinoma, enhances MITF transcriptional activity …


Letter To The Editor Regarding “Questionable Indication For Postoperative Radiotherapy After Surgery For Metastases Of The Major Long Bones”: A Cautionary Note On Methodology And Analysis, Shing Fung Lee, Joel A Finkelstein, Peter J Hoskin, Dirk Rades, Eva Oldenburger, Tracy A Balboni, Daniel E Roos, Hans Kreder, Eric L Chang, Samuel Ryu, Amal Khoury, Kristopher Dennis, Candice Johnstone, Sara R Alcorn, Charles B Simone, Stephanie Brown, Jonas Willmann, Joanne M Van Der Velden, Mateusz Spałek, Yvette M Van Der Linden, Joanna Kazmierska, Nicolaus Andratschke, Emily J Martin, Michael Chao, Hany Soliman, Kenny Kwan, Raymond C H Yau, Shengji Yu, Zhenfeng Li, Albert Yee, Ningning Lu, Xinxin Zhang, Gavin P Jones, W L Chan, Adrian W Chan, Chung Ming Chan, Agata Rembielak, Gustavo N Marta, Vassilios Vassiliou, Saverio Caini, Edward Chow, Henry C Y Wong Jun 2026

Letter To The Editor Regarding “Questionable Indication For Postoperative Radiotherapy After Surgery For Metastases Of The Major Long Bones”: A Cautionary Note On Methodology And Analysis, Shing Fung Lee, Joel A Finkelstein, Peter J Hoskin, Dirk Rades, Eva Oldenburger, Tracy A Balboni, Daniel E Roos, Hans Kreder, Eric L Chang, Samuel Ryu, Amal Khoury, Kristopher Dennis, Candice Johnstone, Sara R Alcorn, Charles B Simone, Stephanie Brown, Jonas Willmann, Joanne M Van Der Velden, Mateusz Spałek, Yvette M Van Der Linden, Joanna Kazmierska, Nicolaus Andratschke, Emily J Martin, Michael Chao, Hany Soliman, Kenny Kwan, Raymond C H Yau, Shengji Yu, Zhenfeng Li, Albert Yee, Ningning Lu, Xinxin Zhang, Gavin P Jones, W L Chan, Adrian W Chan, Chung Ming Chan, Agata Rembielak, Gustavo N Marta, Vassilios Vassiliou, Saverio Caini, Edward Chow, Henry C Y Wong

Faculty, Staff and Students Publications

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