Digital Commons Network^™

Comparison Of Open Thoracoabdominal Repair For Chronic Aortic Dissections And Aneurysms, Ian O Cook, Susan Y Green, Kimberly R Rebello, Qianzi Zhang, Veronica A Glover, Rodrigo Zea-Vera, Marc R Moon, Scott A Lemaire, Joseph S Coselli

Faculty, Staff and Students Publications

Objective: Aortic dissection is common in patients undergoing open surgical repair of thoracoabdominal aortic aneurysms (TAAAs). Most often, dissection is chronic and is associated with progressive aortic dilatation. Because contemporary outcomes in chronic dissection are not clearly understood, we compared patient characteristics and outcomes after open TAAA repair between patients with chronic dissection and those with non-dissection aneurysm.

Methods: We retrospectively analyzed data from 3470 open TAAA repairs performed in a single practice. Operations were for non-dissection aneurysm in 2351 (67.8%) and chronic dissection in 1119 (32.2%). Outcomes included operative mortality and adverse events, a composite variable comprising operative death …

Histone H3k18 & H3k23 Acetylation Directs Establishment Of Mll-Mediated H3k4 Methylation, Geoffrey C Fox, Karl F Poncha, B Rutledge Smith, Lara N Van Der Maas, Nathaniel N Robbins, Bria Graham, Jill M Dowen, Brian D Strahl, Nicolas L Young, Kanishk Jain

Faculty, Staff and Students Publications

In an unmodified state, positively charged histone N-terminal tails engage nucleosomal DNA in a manner which restricts access to not only the underlying DNA but also key tail residues subject to binding and/or modification. Charge-neutralizing modifications, such as histone acetylation, serve to disrupt this DNA-tail interaction, facilitating access to such residues. We previously showed that a polyacetylation-mediated chromatin "switch" governs the read-write capability of H3K4me3 by the MLL1 methyltransferase complex. Here, we discern the relative contributions of site-specific acetylation states along the H3 tail and extend our interrogation to other chromatin modifiers. We show that the contributions of H3 tail …

Obicetrapib On Top Of Maximally Tolerated Lipid-Modifying Therapies In Participants With Or At High Risk For Atherosclerotic Cardiovascular Disease: Rationale And Designs Of Broadway And Brooklyn, Stephen J Nicholls, Adam J Nelson, Marc Ditmarsch, John J P Kastelein, Christie M Ballantyne, Kausik K Ray, Ann Marie Navar, Steven E Nissen, Anne C Goldberg, Liam R Brunham, Danielle Curcio, Erin Wuerdeman, Annie Neild, Douglas Kling, Andrew Hsieh, Mary R Dicklin, Brian A Ference, Ulrich Laufs, Maciej Banach, Roxana Mehran, Alberico L Catapano, Michael H Davidson

Faculty, Staff and Students Publications

Background: Obicetrapib, a novel, selective cholesteryl ester transfer protein (CETP) inhibitor, reduces low-density lipoprotein cholesterol (LDL-C), LDL particles, apolipoprotein (Apo) B, and lipoprotein(a) [Lp(a)] and increases high-density lipoprotein cholesterol (HDL-C) when added to statins with or without ezetimibe. By substantially reducing LDL-C, obicetrapib has the potential to lower atherogenic lipoproteins in patients with atherosclerotic cardiovascular disease (ASCVD) or heterozygous familial hypercholesterolemia (HeFH) whose LDL-C levels remain high despite treatment with available maximally tolerated lipid-modifying therapies, addressing an unmet medical need in a patient population at high risk for cardiovascular events.

Methods and results: BROADWAY (NCT05142722) and BROOKLYN ( …

Amoxicillin And Penicillin G Dosing In Pediatric Community-Acquired Pneumococcal Pneumonia In The Era Of Conjugate Pneumococcal Vaccines, Dustin Huynh, Norint Tung, Quang Dam, Tri Tran, Kristina G Hulten, Christopher J Harrison, Sheldon L Kaplan, Allison Nguyen, Tyler H Do, Amartya Setty, Jennifer Le

Faculty, Staff and Students Publications

Background: Parenteral penicillin G (PENG) and oral amoxicillin (AMOX) are recommended as treatment for pediatric community-acquired pneumonia (CAP). With recent epidemiologic penicillin susceptibility data for Streptococcus pneumoniae, the most common etiology of CAP, the objective of this study was to evaluate optimal dosing regimens of PENG and AMOX based on population pharmacokinetics linked to current susceptibility data.

Methods: Using NONMEM v7.3, Monte Carlo simulations (N = 10,000) were conducted for AMOX 15 mg/kg/dose PO every 8 h (standard-dose), AMOX 45 mg/kg/dose PO every 12 h (high-dose), and PENG 62,500 units/kg/day IV every 6 h using six virtual subjects with ages …

Consensus Statement On The Management Of Nonthrombotic Iliac Vein Lesions From The Viva Foundation, The American Venous Forum, And The American Vein And Lymphatic Society., Kush R Desai, Saher S Sabri, Steve Elias, Paul J Gagne, Mark J Garcia, Kathleen Gibson, Misaki M Kiguchi, Santhosh J Mathews, Erin H Murphy, Eric A Secemsky, Windsor Ting, Raghu Kolluri

Heart and Vascular Articles

A nonthrombotic iliac vein lesion is defined as the extrinsic compression of the iliac vein. Symptoms of lower extremity chronic venous insufficiency or pelvic venous disease can develop secondary to nonthrombotic iliac vein lesion. Anatomic compression has been observed in both symptomatic and asymptomatic patients. Causative factors that lead to symptomatic manifestations remain unclear. To provide guidance for providers treating patients with nonthrombotic iliac vein lesion, the VIVA Foundation convened a multidisciplinary group of leaders in venous disease management with representatives from the American Venous Forum and the American Vein and Lymphatic Society. Consensus statements regarding nonthrombotic iliac vein lesions …

Associations Of Mid-To-Late-Life Inflammation With Late-Life Mobility And The Influences Of Chronic Comorbidities, Race, And Social Determinants Of Health: The Atherosclerosis Risk In Communities Study, Kirby G Parker, B Gwen Windham, Chad Blackshear, Keenan A Walker, Sara B Parker, Ron C Hoogeveen, Christie M Ballantyne, Anna Kucharska-Newton, Priya Palta, Elizabeth Selvin, Maria Vassilaki, Thomas H Mosley, Michael E Griswold

Faculty, Staff and Students Publications

Background: Relationships of midlife inflammation with late-life mobility and influences of chronic health conditions, race, and social determinants of health (SDoH) on these relationships are poorly understood.

Methods: Among 4758 community-dwelling participants (41% men, 20% Black), high-sensitivity C-reactive protein (hsCRP) was measured over 20+ years: in midlife at study visit 2 (V2: 1990-1992, 47-68 years); at V4 (1996-1998, 53-74 years); and with concurrent late-life 4-m gait speed at V5 (2011-2013, 67-88 years, mean 75 years). SDoH measures included race, the national-rank area deprivation index, education, and income. We examined associations of late-life gait speed with midlife hsCRP (V2 continuous and …

Aging-Associated Metabolite Methylmalonic Acid Increases Susceptibility To Pulmonary Fibrosis, Kai Xu, Linke Ding, Wenwen Li, Yaxuan Wang, Shuaichen Ma, Hui Lian, Xiaoyue Pan, Ruyan Wan, Weiming Zhao, Juntang Yang, Ivan Rosas, Lan Wang, Guoying Yu

Faculty, Staff and Students Publications

Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease characterized by pulmonary fibroblast overactivation, resulting in the accumulation of abnormal extracellular matrix and lung parenchymal damage. Although the pathogenesis of IPF remains unclear, aging was proposed as the most prominent nongenetic risk factor. Propionate metabolism undergoes reprogramming in the aging population, leading to the accumulation of the by-product methylmalonic acid (MMA). This study aimed to explore alterations in propionate metabolism in IPF and the impact of the by-product MMA on pulmonary fibrosis. It revealed alterations in the expression of enzymes involved in propionate metabolism within IPF lung tissues, characterized …

Environmental Factors (Rurality, Distribution Of Prescribers, And Altitude) Of People Who Died By Suicide In Montana, 2013- 2022, Anne N. Brown

Electronic Theses and Dissertations

Introduction: Suicide is increasingly prevalent in rural areas across the United States, especially in the western Rocky Mountain states. The connection between suicide and rural residency is not well understood, nor is the relationship between the distribution of prescribers, altitude, and suicide. Purpose: This retrospective quantitative study aimed to describe the characteristics of individuals who died by suicide in Montana and investigate the associations among rurality, distribution of prescribers, altitude, and suicide rate. Methods: Montana suicide mortality data for 2013-22 was used to describe individual characteristics. A second dataset was created for each Zip Code Tabulation Area (ZCTA) level in …

Geospatial Demand For Approved Cleft Care In The United States, Matthew J Parham, Austin D Williams, Sarah A Layon, Heather R Burns, Amjed Abu-Ghname, Larry H Hollier

Faculty, Staff and Students Publications

BACKGROUND: Geographic information systems are powerful tools for characterizing the geospatial factors influencing access to care. As patients with cleft lip and/or palate (CL/P) require long-term care, with numerous operations and therapies, access to timely, quality care is extremely important. This study uses population level analysis and geographic information systems to identify United States counties with limited access to American Cleft Palate Association-approved cleft teams.

METHODS: Natality data were queried from the National Vital Statistics System. Population and geographic data were obtained from the US Census Bureau. The Social Vulnerability Index (SVI) was utilized to account for social inequality. Total …

Treatments And The Perspectives Of Developing A Vaccine For Chagas Disease, Priscila Silva Grijó Farani, Kathryn Marie Jones, Cristina Poveda

Faculty, Staff and Students Publications

Chagas disease (CD) treatment and vaccine development are critical due to the significant health burden caused by the disease, especially in Latin America. Current treatments include benznidazole and nifurtimox, which are most effective in the acute phase of the disease but less so in the chronic phase, often with significant side effects. Here, using the available literature, we summarize the progress in vaccine development and new treatments that promise to reduce CD incidence and improve the quality of life for those at risk, particularly in endemic regions. New treatment options, such as posaconazole and fexinidazole, are being explored to improve …

Electrochemical Properties Of Nickel-Titanium Rotary Endodontic Instruments, Vidyalakshmi Subramanian, Howard W. Roberts, Shengtong Han, Stephanie J. Sidow, David W. Berzins

School of Dentistry Faculty Research and Publications

Introduction

Nickel-titanium rotary endodontic files have been commercially available for decades, but more recent innovations have introduced heat-treated and surface-treated files. This study investigated the corrosion properties of various nickel-titanium files in normal saline and sodium hypochlorite (NaOCl).

Methods

Ten different file brands of size 40 with a 0.04 taper were subjected to electrochemical testing in 0.9% NaCl (saline) and 5.25% NaOCl at room temperature. The Open Circuit Potential (OCP) was observed for 1 hour followed by a cyclic polarization test from −300 to 700 mV and back to −300 mV (vs OCP). Nonparametric ANOVA and a pairwise comparison ( …

Human Platelet Lysate Enhances In Vivo Activity Of Car-Vδ2 T Cells By Reducing Cellular Senescence And Apoptosis, Feiyan Mo, Chiou-Tsun Tsai, Rong Zheng, Chonghui Cheng, Helen E Heslop, Malcolm K Brenner, Maksim Mamonkin, Norihiro Watanabe

Faculty, Staff and Students Publications

BACKGROUND AIMS: Vγ9Vδ2 T cells are an attractive cell platform for the off-the-shelf cancer immunotherapy as the result of their lack of alloreactivity and inherent multi-pronged cytotoxicity, which could be further amplified with chimeric antigen receptors (CARs). In this study, we sought to enhance the in vivo longevity of CAR-Vδ2 T cells by modulating ex vivo manufacturing conditions and selecting an optimal CAR costimulatory domain.

METHODS: Specifically, we compared the anti-tumor activity of Vδ2 T cells expressing anti-CD19 CARs with costimulatory endodomains derived from CD28, 4-1BB or CD27 and generated in either standard fetal bovine serum (FBS)- or human platelet …

Extrudability Window And Offline Test Methods To Predict Buildability Of 3d Printing Concrete, Yu Cun Gu, Kamal H. Khayat

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

This Study Investigates the Effect of Thixotropy and Stiffness Evolution on the Extrudability and Buildability of 3D Printing Concrete. Different Types of Supplementary Cementitious Materials and Limestone Filler Were Used to Prepare Mortars with Varying Levels of Thixotropy and Early-Age Stiffness. Mixtures with Yield Stress and Flocculation (Τfloc) of 180–400 and 420–950 Pa, Respectively, Exhibited Adequate Extrudability Without Plastic Collapse. the Printing Was Completed 8–15 Min after Mixing at a Vertical Build-Up Rate of 138 Mm/min. Several Process Parameters, Including Rest Time to Secure a Penetration Resistance of 150 KPa (T150) and Penetration Resistance at Various Rest Times Were Developed …

Quantifying The Impact Of Technology Utilization On Schedule And Cost Performance In Construction Projects, Fareed Salih, Islam H. El-Adaway

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

There Has Been a Plethora of Research on the Performance of Schedule and Cost in Construction Projects. However, Current Research Falls Short in Investigating the Combined Contribution of Different Construction Technologies on Project Performance Metrics. Specifically, None of the Previous Efforts Have Used Integrated Earned Value Management (EVM) Parameters and Utilized Construction Technologies to Assess Project Schedule and Cost Performance. This Paper Fills This Knowledge Gap. to This End, a Multistep Research Methodology Was Employed to (1) Explore the Utilization Ratings of 13 Construction Technologies based on Data Collected from 52 Industry Experts; (2) Rank These Technologies in Terms of …

Rheology Modification Of Flowable Mortar With Co2, Sean Monkman, Soo Duck Hwang, Kamal Khayat

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

The Rheological Properties of Mortar Samples with Different Additions of CO₂ during Mixing Were Determined. Flowable Cement-Based Mortars at Three Different W/c (0.55, 0.45 and 0.35) Were Produced and the Effects of CO₂ Gas Were Examined on the Fresh Properties of Slump Flow, Yield Stress and Plastic Viscosity. According to the Experimental Results, the Mortar Yield Stress and Plastic Viscosity Increased Faster over Time Than in a Reference System with the Increasing Addition of CO₂ and Greater Effects Were Seen at the Lowest W/c of 0.35 Than at the Others. the Impact of the CO₂ on …

The Impact Of Teaching Residency Programs On Burnout In Urban Schools, Jessica Ghazi

Masters Theses and Doctoral Dissertations

This doctoral research investigates burnout of urban educators in a large southeastern district for a mixed methods study. Research questions one and two investigate demographic and organizational variables to determine if they are predictors of burnout or any of the three subcomponents, respectively. In research question three, teaching residencies were explored to determine if they provide appropriate preparation for teaching in urban schools which can limit burnout of educators. Variable data was collected through surveys and analyzed quantitatively of a sample of 69 urban teachers across 12 schools. For research question four, a subsample of teachers participated in focus groups …

College Students' Perceptions Of Malingering Attention Deficit Hyperactivity Disorder, Nicolas Maynard

Masters Theses and Doctoral Dissertations

This study assessed college students’ knowledge and perceptions of attention deficit hyperactivity disorder (ADHD) to help identify patterns of behavior in those who malinger ADHD in a college environment. Specifically, I sought to determine what behaviors college students attribute to ADHD and how those behaviors are demonstrated when malingering the disorder. Participants in this study were neurotypical college students and those with a valid ADHD diagnosis. Half of the neurotypical participants were instructed to malinger ADHD on all study assessments. Participants who were instructed to malinger ADHD subjectively reported significantly more symptoms than their neurotypical peers, but not their valid …

Influence Of Aggregate Properties On Skid Resistance Of Pavement Surface Treatments, Alireza Roshan, Magdy Abdelrahman

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

Skid resistance is a critical aspect for traffic safety since it significantly influences vehicle control and minimizes the distance required for emergency braking. The surface characteristics of pavements play a pivotal role in determining skid resistance. To achieve the optimal skid resistance performance, the pavement must sustain a specific level of friction. Thus, it is advantageous to apply surface treatments in areas that require enhanced friction. This study investigates the impact of factors such as the aggregate source, size, morphological properties, and abrasion levels on the skid resistance and frictional characteristics of a high-friction surface treatment (HFST). A complete investigation …

The Effectiveness Of Waste Tire Pyrolysis Oils (Wtpos) As Rejuvenating Agents For Asphalt Materials, Ahmed S. El-Ashwah, Magdy Abdelrahman

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

The continuous increase in solid waste materials, such as waste tires, underscores the critical importance of recycling them to mitigate environmental impact and promote sustainable resource management. This research study evaluated the effectiveness of utilizing waste tire pyrolysis oils (WTPOs) as recycling agents for asphalt materials. The chemical composition and thermal behavior of WTPO were analyzed using Fourier transform infrared (FT-IR) spectroscopy and thermogravimetric analysis (TGA). Mechanically, the prepared WTPO binders were assessed by measuring dynamic viscosity and changes in high- and intermediate-temperature performance grades. Additionally, the cracking susceptibility of the binders was evaluated using the Glover-Rowe (G-R) parameter. The …

Indefinability Of Effective Stress For Unsaturated Soils, Xiong Zhang, Sandra Houston

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

For decades, researchers have searched for an unsaturated soil effective stress that performs analogously to effective stress for saturated soils and provides some simplifications over net stress and suction approaches. A recent debate is whether problems identified with unsaturated soil effective stress can be resolved via elastoplastic analyses. Effective stress equations are reviewed and categorized as being based on volume change, shear strength, yield, or degree of saturation. These equations are evaluated for consistency with saturated soil effective stress expectations using the Barcelona basic model (BBM), simplified into an integrated elastoplastic framework using the modified state surface approach (MSSA). Under …

First Diffusion Course: "The Structure Of Language As A Connection Between Artificial Intelligence, Information And Ethics", Dioneia Monte-Serrat

Journal of Humanistic Mathematics

From August 22nd to November 21st, the first Diffusion Course on “The structure of language as a connection between artificial intelligence, information and ethics” will take place on a Thursday of each month, in Ribeirao Preto, Brazil. You are cordially invited to sign up for in-person classes and join other researchers and students on this course.

7th International Conference On Creative Mathematical Sciences Communication (Cmsc`24), Frances A. Rosamond

Journal of Humanistic Mathematics

The 7th International Creative Mathematical Sciences Communication (CMSC) conference is scheduled for October 2024 in Trier, Germany. Initiated in Darwin, Australia in 2013, CMSC aims to explore novel methods of imparting computational thinking to diverse audiences including non-specialists, modern citizens, and children. Participants from around the world and from various and interdisciplinary disciplines such as science, education, dance, drama, and visual arts convene to exchange ideas, present experimental approaches, and collaborate on engaging children in the exploration of ongoing, unresolved research challenges.

Oh Statistics!, Heather L. Cook

Journal of Humanistic Mathematics

This poem was written about statistics and the usefulness thereof.

Discordium Mathematica - A Symphony In Aleph Minor, Vijay Fafat

Journal of Humanistic Mathematics

How did Mathematics arise? Who created it? Why is it subject to Godel’s Incompleteness Theorems? And what does all this have to do with Coleridge’s poem, “Kubla Khan”, and “The Person from Porlock”? Here is a complete mythology of Mathematics set in an epic poetry format, fusing thoughts and verses from Western religions and Eastern mysticism… Those with immense patience and careful reading shall reap the fruit… (best read on a large screen or in printed form)

Pi: A Perpetual Journey, Ravindra K. Bisht

Journal of Humanistic Mathematics

A brief history of the constant pi is presented with a poetic flavor.

Love Is No Mean Thing: A Larkin Logarithm, Michael P.H. Stanley Md

Journal of Humanistic Mathematics

This poem was recited at a marriage recently in Vermont. I met the groom in my freshman year. He was the first college friend I ever made, and he used to burst into the room like Cosmo Kramer and settle down in an easy-chair to think about math (my side of the dorm was quieter than his). I thought that was remarkable and delightful, and so, when the task came to write a matrimonial poem for him, I selected a mathematical conceit. The poem concludes with a mathematical paraphrasing of Philip Larkin's last line from Arundel Tomb.

Eighth Grade Algebra, Joseph Chaney

Journal of Humanistic Mathematics

This is a poem about the affirming power of algebra in the life of a teenager.

Prime Motivation Of Eratosthenes, Pamela L. King

Journal of Humanistic Mathematics

The sieve of Eratosthenes is used as a metaphor for the concept of people falling through the social safety net, and people who were once excluded, making efforts to increase inclusiveness.

Poems From The Series "At The Dimensional Border", Philip Fried

Journal of Humanistic Mathematics

Poems about the border between the second and third dimensions, on geometry and the human condition.

Mathematical Graffiti: Bridges 2023 Clerihew Collection

Journal of Humanistic Mathematics

Clerihews are poems of a form invented by Edmund Clerihew Bentley around the turn of the 19th-20th century. The poems are typically biographical, humorous, and are made up of two couplets. The rhyming pattern is always aabb, but the meter of the two couplets is usually not the same. The first line is simply the name of the person, the other three lines relate to the subject, often in an absurd way. If the rhyme is slightly off, or the rhythm irregular or awkward, or the facts a bit confused, so much the better. The present collection of clerihews, written …