Digital Commons Network^™

Modeling Hyperglycemia With Induction Variants In Mice As Preclinical Test Animals, Setiyo Santoso, Widarika Hapsari, Deksa Putra

Pharmacology and Clinical Pharmacy Research

Inducing hyperglycemia in animal models is crucial for preclinical research on anti-diabetic drug development, especially when genetically diabetic test animals are unavailable. Various induction methods have been employed to elevate glycemic levels in test animals. However, there is a lack of substantial literature proving the effectiveness and stability of these induction alternatives. This study aims to compare the stability of glycemic levels and assess histopathological changes in mice induced by dextrose, streptozotocin, and alloxan. Our protocol involved dividing mice into six groups of five, each with a control group. Mice in Groups A and D were exposed to alloxan monohydrate, …

Prescribing Pattern Of Corticosteroid In Dermatologic Disorder At Tertiary Care Teaching Hospital In Western Indian, Zankrut Patel, Dhiren Patel, Jatin Patel, Sumit Patel

Pharmacology and Clinical Pharmacy Research

Based on their potent immunosuppressive and anti-inflammatory properties, corticosteroids are essential for treating several skin disorders. Due to their lesser systemic toxicity, topical treatments are recommended. The use of corticosteroids in Indian dermatology practice, however, is not well documented. This study aims to analyze the prescribing patterns of corticosteroids for dermatologic disorders. In the outpatient dermatology department of GCS Hospital, Ahmedabad, a cross-sectional, observational study was conducted for six months, from March 2021 to August 2021. We looked at prevalent skin problems and prescribing patterns in 500 prescriptions. A descriptive statistical analysis was done following the compilation of all the …

Nanoemulsion Formulation As A Drug Delivery System For Coleus Atropurpureus Bioactive Compounds, Marsella Oktavioni, Dian A.E Natasya, Yusnaidar Yusnaidar, Madyawati Latief, Indra Tarigan

Pharmacology and Clinical Pharmacy Research

Miana plant (Coleus) is a plant with compound flowers. Miana leaves have various bioactive compounds widely used to treat diseases such as fever, cold, cough, headaches, asthma, constipation, and skin diseases. Based on phytochemical screening of Coleus atropurpureus Benth. Several bioactive compounds are produced, such as sterols, terpenoids, alkaloids, phenols, flavonoids, glycosides, lactones, catechols, and tannins. Miana leaf extract has been tested for antioxidants using the DPPH method, and the IC50 value obtained from the antioxidant test results is 3.80 ppm and is categorized as a powerful antioxidant. There were four formulations of miana leaf extract nanoemulsion. Based on the …

Evaluation Of Antibiotic Use In Pediatric Inpatients At One Of Bandung Regional Hospitals In August 2023, Purti Maharani, Imam Wicaksono, Falerina Puspita, Hijrah Zainudin

Pharmacology and Clinical Pharmacy Research

Infectious diseases are a major concern in the field of health, especially in developing countries like Indonesia. Children are vulnerable to infections because their immune systems are not fully developed. Proper management is necessary for the prevention and treatment of infectious diseases in pediatric patients. Antibiotics are the primary choice for addressing bacterial infections. However, the increased use of antibiotic can contribute to high levels of antimicrobial resistance (AMR), rendering infection treatment ineffective. The evaluation of antibiotic use can be conducted through the ATC/DDD method, which focuses on the quantity and types of antibiotics used. Although this method provides a …

Prospect Study Of Anti-Inflammatory Activity By Identification Of Muntingia Calabura Leaf Infusion, Shenny Permana, Muchamad Yusuf, Aufa Putriana, Jasmine Sukmayani, Ratu Sudrajat, Miski Khairinisa, Indah Wahyuni, Enny Rohmawaty, Muhammad Bashari, Ronny Lesmana, Aziiz Rosdianto

Pharmacology and Clinical Pharmacy Research

Many diseases occur due to inflammation that is not handled properly. One of the feature of inflammation is swelling or edema. Inflammation can be handled with traditional medicine, such as Muntingia calabura L. (M. calabura L.) Pharmacologically, this plant extract is reported to have antipyretic, analgesic, anti-inflammatory, antioxidant, and antibacterial. Metabolite compound contained in M. calabura L. has the potential as an anti-inflammatory agent. The objective of this study is to ascertain the secondary metabolites contained in M. calabura L. leaves infusion. This experimental research method includes the simplicia making and infusion of M. calabura L. leaves by cold infusion …

Teacher Knowledge And Confidence Integrating Social Change Concepts In K–12 Classrooms, Amy White, Fran Reed, Tina Marshall-Bradley, Kathy Strang

Journal of Sustainable Social Impact

The purpose of this survey research was to examine the perspectives of K–12 classroom teachers about their knowledge of social change concepts and their confidence in implementing these into their existing curriculum. A questionnaire was used to (a) examine the perspectives of K–12 classroom teachers about the knowledge, skills, and resources they need to implement social change concepts into their teaching and (b) define areas of social change that teachers struggle to implement in K–12 classrooms. We employed Wilcoxen signed rank tests to determine if differences existed between what teachers reported they knew and their confidence in integrating 11 social …

Analysis Of Cost-Effectiveness Of Antihypertensive Therapy In Hypertension Patients At Al-Ihsan Regional Public Hospital In 2023, Masyitah Isnaini, Widiah Widiarti, Miski Khairinisa

Pharmacology and Clinical Pharmacy Research

Hypertension is a disease that causes an abnormal increase in blood pressure, which causes cardiovascular disease. Long-term hypertension therapy requires large costs. Apart from that, existing antihypertensives are also very varied, so a cost-effectiveness analysis is needed in order to choose medications that balance costs and advantages. This study aims to determine the most economical antihypertensive medication at Al-Ihsan Regional Public Hospital in Baleendah. Based on patient medical records, this study was carried out retrospectively. Therapy data and treatment costs are the basis for the data collection process. The data is processed descriptively. The reduction in blood pressure that meets …

Developing Future Managers Through Business Simulation Gaming In The Uk And Hong Kong: Exploring The Interplay Between Cognitive Realism, Decision-Making And Performance, Jonathan Lean, Robert Newbery, Jonathan Moizer, Mohamed Haddoud, Wai Mun Lim

Plymouth Business School

PurposeThis paper investigates how individuals' decision-making approach and perceptions of a game's cognitive realism affect the performance of virtual businesses in a web-based simulation game.Design/methodology/approachSurvey data are collected from 274 business simulation game users and is analysed using the fsQCA technique.FindingsThe study identifies three alternative pathways to high and low performance in a business simulation game. Results indicate that a flexible decision-making approach exists in all high performance pathway solutions. Where a game is perceived to be realistic, a more focused decision-making approach is associated with high performance. However, where perceived cognitive realism is absent, a less focused experimental decision-making …

Computational Investigations Of Optical Properties Of Plasmonic Nanoparticle Assemblies By Dda Method, Saghar Gomrok

Electronic Theses and Dissertations Archive

Plasmonics is a multidisciplinary field focused on the study of collective oscillations of conduction electrons in metals, known as plasmons. These plasmons lead to unique optical responses when coupled with nanostructures, enhancing electric fields at the metal surface at specific wavelengths. Surface plasmon resonance (SPR) occurs at the interface of metal-dielectric structures, while localized surface plasmon resonance (LSPR) manifests within metallic nanoparticles (NPs), influenced by composition, size, shape, and surroundings. Gold (Au) and silver (Ag) NPs are well-known for distinctive LSPR-induced optical properties. Assemblies of Au or Ag metallic NPs allow further tuning of plasmonic behaviors. Moreover, packing metallic NPs …

Laser-Induced Electrochemical Biosensor Modified With Graphene-Based Ink For Label-Free Detection Of Alpha-Fetoprotein And 17Β-Estradiol, Ridma Tabassum, Pritu P. Sarkar, Ahmed Hasnain Jalal, Ali Ashraf, Nazmul Islam

Mechanical Engineering Faculty Publications

In this research, a novel electrochemical biosensor is proposed based on inducing graphene formation on polyimide substrate via laser engraving. Graphene polyaniline (G-PANI) conductive ink was synthesized by planetary mixing and applied to the working zone of the developed sensor to effectively enhance the electrical signals. The laser-induced graphene (LIG) sensor was used to detect alpha-fetoprotein (AFP) and 17β-Estradiol (E2) in the phosphate buffer saline (PBS) buffer and human serum. The electrochemical performance of the biosensor in determining these biomarkers was investigated by differential pulse voltammetry (DPV) and chronoamperometry (CA). In a buffer environment, alpha-fetoprotein (AFP) and 17β-Estradiol detection range …

Navigating Global Engineering Education Accreditation: Assessing Ethical Integration And Charting Pathways For Progress, Shannon M. Chance, J Seniuk Cicek, A R Bielefeld, S Hladik, Diana Adela Martin, D M Riley

Research Outputs: 2025-Present

Accreditation in engineering has been widely adopted, enabled by notable harmonization among accrediting bodies worldwide. This alignment, facilitated by accords among nations and regions, fosters a shared understanding of expectations critical for the globalized engineering profession. While ensuring graduates are equipped with essential skills for international collaboration, engineering education grapples with defining and instilling ethics, and the problematic nature of this endeavor is complicated by vague and ambiguous terminology within accreditation documents. Addressing this gap requires navigating power dynamics among education, accreditation, and licensure alongside creating localized, meaningful educational experiences. This paper overviews one section from the forthcoming Routledge International …

Trackins (Trk-Targeting Drugs): A Novel Therapy For Different Diseases, George N Chaldakov, Luigi Aloe, Stanislav G Yanev, Marco Fiore, Anton B Tonchev, Manlio Vinciguerra, Nikolai T Evtimov, Peter Ghenev, Krikor Dikranian

2020-Current year OA Pubs

Many routes may lead to the transition from a healthy to a diseased phenotype. However, there are not so many routes to travel in the opposite direction; that is, therapy for different diseases. The following pressing question thus remains: what are the pathogenic routes and how can be they counteracted for therapeutic purposes? Human cells contain >500 protein kinases and nearly 200 protein phosphatases, acting on thousands of proteins, including cell growth factors. We herein discuss neurotrophins with pathogenic or metabotrophic abilities, particularly brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), pro-NGF, neurotrophin-3 (NT-3), and their receptor Trk (tyrosine receptor …

Novel Mutation Leading To Splice Donor Loss In A Conserved Site Of Dmd Gene Causes Duchenne Muscular Dystrophy With Cryptorchidism, Jianhai Chen, Yangying Jia, Jie Zhong, Kun Zhang, Hongzheng Dai, Guanglin He, Fuping Li, Li Zeng, Chuanzhu Fan, Huayan Xu

Faculty, Staff and Students Publications

Background: As one of the most common congenital abnormalities in male births, cryptorchidism has been found to have a polygenic aetiology according to previous studies of common variants. However, little is known about genetic predisposition of rare variants for cryptorchidism, since rare variants have larger effective size on diseases than common variants.

Methods: In this study, a cohort of 115 Chinese probands with cryptorchidism was analysed using whole-genome sequencing, alongside 19 parental controls and 2136 unaffected men. Additionally, CRISPR-Cas9 editing of a conserved variant was performed in a mouse model, with MRI screening used to observe the phenotype.

Results: In …

A New Optimization Approach Based On Neural Architecture Search To Enhance Deep U-Net For Efficient Road Segmentation, Narges Saeedizadeh, Seyed Mohammad Jafar Jalali, Burhan Khan, Parham Mohsenzadeh Kebria, Shady Mohamed

Research outputs 2022 to 2026

Neural Architecture Search (NAS) has significantly improved the accuracy of image classification and segmentation. However, these methods concentrate on finding segmentation structures for natural or medical applications. In this study, we introduce a NAS approach based on gradient optimization to identify ideal cell designs for road segmentation. To the best of our knowledge, this work represents the first application of gradient-based NAS to road extraction. Taking insight from the U-Net model and its successful variations in different image segmentation tasks, we propose NAS-enhanced U-Net, illustrated by an equal number of cells in both encoder and decoder levels. While cross-entropy combined …

Kindergarten Through Third-Grade Teachers’ Perceptions Of Implementing The Science Of Teaching Reading Practices, Shari Yvonne Ehly

Walden Dissertations and Doctoral Studies

In 2019, declines in reading achievement across Texas motivated changes for teacher recertification, which required 60-hour professional development in the science of teaching reading (STR). The problem this study addressed was the challenges K-Grade 3 reading teachers encountered when implementing the recently adopted Reading Academy content at a large urban school in Texas. The purpose of this basic qualitative project study was to explore the challenges K through Grade 3 reading teachers encountered when implementing the recently adopted Reading Academy content at a large urban school in Texas. The implementation science conceptual framework guided this study on the fidelity of …

Safety And Effectiveness Of Using Disposable Ultrasonic Shears To Coagulate 5–7 Mm Blood Vessels: Protocol For A Prospective, Multicenter, Randomized, Parallel Controlled, Non-Inferiority Clinical Trial, Xipeng Wang, Chengqiang Li, Junqiang Fan, Jian Hu, Mingsong Wang, Hecheng Li

Faculty, Staff and Student Publications

BACKGROUND: The ultrasonic scalpel is widely used during surgery. It is safe and effective to close the pulmonary artery branch vessels of 7 mm or below with an ultrasonic energy device as reported. However, there have been no multicenter randomized clinical trial to assess the safety and effectiveness of using ultrasonic scalpel to coagulate 5-7 mm blood vessels in thoracic surgery.

METHODS: This is a prospective, multicenter, randomized, parallel controlled, non-inferiority clinical trial. A total of 144 eligible patients planning to undergo lung or esophageal surgery will be randomly allocated to the experimental group and the control group. The investigational …

Medicaid Coverage As A Critical Component In Care Coordination And Continuity In Health Care Access During Reentry For Justice-Involved Individuals In Maryland, Bernard Bendenkaga Alenda

Walden Dissertations and Doctoral Studies

Incarcerated individuals in the United States have a high disease burden. Moreover, most of them are released from incarceration without health coverage. The problem is that most incarcerated people in Maryland return to the community from incarceration without health coverage and cannot access health care. The purpose of this qualitative study was to understand how Medicaid enrollment staff and managers of the Medicaid program perceive the experiences and challenges of justice-involved individuals in navigating the Medicaid system in Maryland. The study was grounded in the behavioral model for vulnerable populations. The main research question aimed at understanding how the enrollment …

Association Of High Fibrinogen To Albumin Ratio With Long-Term Mortality In Patients With Spontaneous Intracerebral Hemorrhage, Shiping Chen, Yu Zhang, Yangchun Xiao, Xin Cheng, Liyuan Peng, Yixin Tian, Tiangui Li, Jialing He, Pengfei Hao, Weelic Chong, Yang Hai, Chao You, Fang Fang

Department of Medical Oncology Faculty Papers

BACKGROUND: The association between fibrinogen-to-albumin ratio (FAR) and in-hospital mortality in patients with spontaneous intracerebral hemorrhage (ICH) has been established. However, the association with long-term mortality in spontaneous ICH remains unclear. This study aims to investigate the association between FAR and long-term mortality in these patients.

METHODS: Our retrospective study involved 3,538 patients who were diagnosed with ICH at West China Hospital, Sichuan University. All serum fibrinogen and serum albumin samples were collected within 24 h of admission and participants were divided into two groups according to the FAR. We conducted a Cox proportional hazard analysis to evaluate the association …

Potential Value Of Brazzein-Yeast As A Broiler Chicken Feed Additive, Lauren Ruth Neuleib

Theses and Dissertations

A variety of flavors, including sweeteners, have been used in animal feeds to improve feed palatability and increase feed intake by livestock (Chen et al., 2020). While many of these sweeteners are found in the form of carbohydrates, brazzein is a sweet-tasting protein. This study was conducted to identify the potential of brazzein to influence feed intake by livestock, using poultry as a model. The preliminary study's purpose was to develop methods appropriate for the subsequent feeding study. In the preliminary study, eight pens of five birds were fed one of four treatment diets: Control or the Control plus one …

Auditor-Firm Conflict: Theoretical Concepts Application And Analysis Of The Power Dynamics Involved, Idowu Eferakeya

Journal of Accounting Auditing and Business

This study undertakes a theoretical analysis of the auditor-firm conflict. It relied on  the review of literature methodology  contextualized on  auditor’s appointment ,  firm economic pressure , management bargaining power, auditor’s fear of losing a firm, firm’s management economic power over the auditor, auditor’s personal attributes and moral reasoning, auditor’s tenure, audit fees, audit market competitiveness, non-audit services, audit firm size and the firm’s financial condition. The study relied on Goldman and Barlev model, exchange and dependency theories to explain the likely power positions in the auditor-firm relationship. Deductively the study based on the contexts indicated the presence of an …

Workshop Wine Wednesdays: Improving Knowledge And Motivations About Local Wines., Aude A. Watrelot, Sarah Al-Mazroa Smith, Sarah L. Francis

Journal of Extension

The grape and wine industry in Iowa is based on non-Vitis vinifera grapes, which are not well-known by consumers and come with their own set of challenges, such as promotion. The Wine Wednesdays workshop focused on promoting awareness and knowledge of local wines and grapes. Results indicate gain in self-perceived knowledge and intention of behavior changes toward local grapes and wines. These workshops also participate in the development of relationships among wineries, which is overall beneficial for the local grape and wine industry.

The Last Resort: Reducing Avoidable Employee Harm By Improving The Application Of The Disciplinary Policy And Process, Andrew Cooper, Kevin Rui-Han Teoh, Ruth Madine, Adrian Neal, Aled Jones, Ammarah Hussain, Doris A. Behrens

School of Nursing and Midwifery

Introduction: There is growing evidence within the healthcare sector that employee investigations can harm individuals involved in the process, an organization’s culture and the delivery of its services.MethodsThis paper details an intervention developed by an NHS Wales organization to reduce the number of its employee investigations through an organization-wide focus that promoted a ‘last resort’ approach and introduced the concept of ‘avoidable employee harm’. A range of associated improvement initiatives were developed to support behavior change among those responsible for determining whether an employee investigation should be initiated.Results: Over a 13-month period, organizational records showed an annual reduction of 71% …

The Examination Of The Mathematical Calculation On Premium Reserve Modifications For Endowment-Life Insurance Products, Farisa Salwa Fatimah, Debrina Ferezagia, Wira Darmiza

Jurnal Administrasi Bisnis Terapan

Insurance offers numerous advantages in managing the diverse dangers it encounters. The level of compensation provided is contingent upon the magnitude of the premium remitted. A fraction of the premium collected by the company must be allocated as a premium reserve to ensure that the company will not have any challenges in settling future claims. The calculation of premium reserves is performed through the utilization of prospective and retrospective reserve methods, which rely on net premiums as the foundation for the computation. The premium reserve calculation approach employs both the Canadian and Full Preliminary Term methodologies. The objective of this …

Storywood: Collaborating With Opaque Unknowable Others Through Oil Painting, Tanya J. Behrisch

Journal of Contemplative and Holistic Education

This paper demonstrates the use of contemplation and arts-based research (ABR) to explore intersubjectivity between myself and other opaque beings. Through a walking meditation, I experience an affective encounter with a plywood board found lying on a beach. The board radiates agency and mysterious stories about its passage through the world. Drawing on philosopher Tim Lilburn’s concept of permeable attention and Bennett’s theory of vibrant matter, I discover the storied nature of the damaged board and resonances between its stories and my own. By practicing perceptual openness, I discern vitality shimmering beyond the visible surface of the board. During my …

Why Researchers Need To Hear Practitioners’ Voices: A Call To Action, David Wolff, Donna Zerr, Carissa Gober

Essays in Education

Educators play a crucial role in shaping student learning experiences. Practitioners engage in scholarly inquiry daily in classrooms and educational settings. Scholarly inquiry varies based on context and student needs. By viewing classrooms as research labs, educators can foster curiosity and develop research. It is the goal of this article to encourage educators to engage in The Scholarship of Teaching and Learning by formalizing their insights into publishable writings.

The Relationship Between Mental Health, Self And Other Stigma, And Help-Seeking Behaviors In Ethnic Minority Undergraduate Students, Briane Souki

Ursidae: The Undergraduate Research Journal at the University of Northern Colorado

Racial and ethnic minority undergraduate students are disproportionately affected by mental health challenges and are less likely to seek support due to self-stigma and stigma from others, cultural perceptions of mental health, and help-seeking behaviors (Tucker et al., 2013). It is critical to understand mental health in cultural contexts because they influence help seeking behaviors for ethnic minority college students. These stigmas are thoughts that influence the help-seeking behaviors of students. Many ethnic minority students have internalized self-stigma toward help seeking. Part of overcoming minority student hesitancy toward help-seeking is to promote culturally aware mental health practices. In predominantly white …

Divine Retribution, Anna Payne

Ursidae: The Undergraduate Research Journal at the University of Northern Colorado

Sexual abuse has always been an issue in all cultures throughout the world and history. Easton et al. delved into the problems of barriers to disclosing child sexual abuse with 460 male participants which showed that 61.7% of them reported CSA at the hands of a priest. As that study was conducted, Helsel and McCormack tackled the effects of CSA on the nervous system and psyche. While religion is used as a coping mechanism, it is also a tool for maltreatment from clergy sexually abusing children to parents seeking ways to rid the child of demons. There have been over …

Effects Of Emotional Intelligence And Social Support On The Relationship Between Childhood Maltreatment And Disordered Eating, Rachel E. Kilby

Ursidae: The Undergraduate Research Journal at the University of Northern Colorado

Current research has established a connection between childhood maltreatment and eating disorders, and some studies have looked at emotional intelligence or social support as mediators of this connection. However, little research has looked at how emotional intelligence and social support work together in the relationship between childhood maltreatment and eating disorders. This study looked at how emotional intelligence and social support act as mediators in this relationship. Undergraduate students (N=134) were administered the Childhood Trauma Questionnaire (CTQ-90), Wong-Law Emotional Intelligence Scale (WLEIS), Difficulties in Emotion Regulation Scale (DERS), Perceived Social Support Scale (PSSS), and the Eating Attitudes Test (EAT-26). Correlations …

Denigration Of The Body In Plato’S Philosophy, Jamie Alexander

Ursidae: The Undergraduate Research Journal at the University of Northern Colorado

The denigration of the body is a common feature of Western religions, but its origins can be traced back to Plato. His teacher, Socrates, proposed a separation of body and soul, but careful reading of Plato's Dialogues suggest Plato took a particularly negative view of the body compared to his predecessor. Analyzing the effects of the Peloponnesian War on Plato's life and society, this article looks at reasons Plato may have had a developed an unfavorable view toward the body by comparing "war bodies" with "intellectual bodies," and discussing the impact democracy had on Plato's worldview.

Friends Of The Library Meeting, David Lodwick

Friends of the Library Events

Friends of the Library Meeting

July 18, 2024

The agenda and minutes are attached.