Digital Commons Network^™

Investigating The Effect Of Artificial Sweeteners On Fitness And Metastasis In Drosophila Melanogaster, Om R. Patel

Honors Undergraduate Theses

Artificial sweeteners are widely used sugar substitutes, yet their potential effects on health remain poorly understood. For example, more evidence suggests that frequent consumers of sugar substitutes may also be at increased risk of excessive weight gain, metabolic syndrome, and type 2 diabetes, which contradicts the original purpose of artificial sweeteners. This thesis investigates the impact of artificial sweeteners on health using Drosophila melanogaster as a model organism, focusing on three key areas: viability, excretion, and cancer metastasis. Viability assays revealed that flies exposed to artificial sweeteners exhibited a decrease in progeny, with some concentrations increasing progeny but most decreasing …

Post-Translational Modification Of The Low-Density Lipoprotein Receptor By Serine Proteases, Matthew E. Ruiz

Honors Undergraduate Theses

Hypercholesterolemia is a disease affecting many Americans and adults worldwide and can lead to further complications such as atherosclerosis, stroke, or pulmonary embolisms making it a major risk factor for heart disease. The disease states are caused by chronically elevated levels of VLDLs that get broken down into LDLs. Cells expressing the LDLR can endocytose LDLs from the blood for use intracellularly as cholesterol and prevent plasma cholesterol deposition in the endothelium. Current treatments include leading healthier lifestyles through dieting and exercise, or pharmacological treatments targeting cellular cholesterol production or dietary cholesterol uptake from the GI tract. The SREBPs are …

Physical Activity And Hypertension Outcomes Around Menopause In Adult Women—A Secondary Analysis Of The All Of Us Research Program, Meriam F. Naguib

Honors Undergraduate Theses

Hypertension significantly impacts menopausal women due to a decrease in estrogen levels. That is due to estrogen level changes, causing many metabolic alterations, one of which is increased vascular resistance, leading to hypertension. Advanced treatments are made available to help alleviate the condition; however, lifestyle modifications—especially physical activity—show a critical role in hypertension control. This thesis explored the effect of physical activity as a non-pharmacological, lifestyle intervention on hypertension in women by menopausal status (pre-, peri-, and post-menopausal). This study used a secondary analysis with a retrospective design. Physical activity was defined using the American Heart Association's (AHA) guidelines (i.e., …

Threading The Needle: Chinese American Adoptees And The In-Between, Annalee Johnson

Honors Undergraduate Theses

Threading the Needle is a short documentary that investigates the relationships between Chinese American adoptees, their families, and their heritage. The film features two primary participants, Mia Nails and Annalee “AJ” Johnson as they reflect on their Asian American identity, experiences with racism, and their struggles with cultural estrangement. The similarities and differences in their perspectives shed light on both the wonderful and the heartbreaking circumstances of adoption. The contemporary value of the film lies in how it challenges popular representations of the Asian American experience: Though in recent years, Asian American media has become more present in popular culture, …

Assessing The Relationship Between Perceived Psychological And Physical Pain In Adults With Orthopedic Pain, Daniel C. Karimi Dehkordi

Honors Undergraduate Theses

Suicide remains a public health concern in the U.S., particularly among individuals experiencing chronic pain and psychological distress. This cross-sectional study investigated the relationship between perceived physical and psychological pain in 41 adults with chronic orthopedic conditions. The relationship between other risk and protective factors and perceived levels of pain distress was also examined. Results showed a significant positive correlation between psychological distress and physical pain (r(39) = 0.388, p < .05) and psychological distress and depressive/anxiety symptoms (r (39) = 0.477, p < .01). Psychological distress was moderately associated with feelings of hopelessness (r (39) = 0.403, p < .01), however, the relationship between physical pain and hopelessness was weak and nonsignificant (r (39) = -0.06, p = .71). Contrary to expectations, emotional support did not buffer the effects of psychological distress (r (39) = 0.07, p = 0.66). Mediational analysis confirmed that emotional support did not influence the relationship between physical pain and psychological distress (Beta (β) = -0.969, p = 0.572; Sobel Z = 0.5598, p = 0.575). Age was not correlated with psychological distress (r (39) = -0.24, p = 0.13) or mental health symptoms (r (39) = -0.05, p = .77). While there was no significant difference across sex, males reported higher mental health symptomatology and psychological distress scores than female counterparts. These findings underscore the direct impact of physical pain on psychological distress and challenge assumptions about the protective role of social support. The study highlights the need for integrated, multidisciplinary interventions targeting both physical and psychological pain to mitigate suicide risk among individuals with chronic orthopedic conditions. Future research should iii explore alternative support mechanisms and resilience-building strategies to address the complex interplay of pain, distress, and suicidality.

A Systematic Review Of Dietary Trends, Influencing Factors, And Their Impacts On Cardiovascular Health In Turkish Populations, Pelin L. Özoğlu

Honors Undergraduate Theses

Cardiovascular disease (CVD) is the leading cause of death globally, including in Türkiye. One key factor influencing CVD prevention is dietary patterns, which directly impacts cardiovascular health. Türkiye traditionally follows the Mediterranean diet (MedDiet), which is acclaimed for its cardiovascular benefits. Despite this, Türkiye continues to experience high rates of CVD, with projections indicating that CVD mortality will double for both men and women by 2030. It is crucial to address diet-related factors, including potential nutritional deficiencies, to reduce cardiovascular health risks.

This research aims to analyze the Turkish community's adherence to the Mediterranean diet to understand why CVD prevalence …

The Effects Of School-Based Menstruation Education Programs On Anxiety And Self-Efficacy In Adolescent Girls: A Systematic Review, Hannah C. Hart

Honors Undergraduate Theses

A significant global knowledge gap exists for adolescent girls regarding what constitutes a healthy menstrual cycle, proper menstrual hygiene practices, and the implications of reproductive maturity that is ushered in by menarche. This limited understanding can lead to poor health outcomes and the development of negative sentiments and beliefs surrounding the normal experience of menstruation.

This systematic review aims to comprehensively investigate the current state of research regarding the effects of school-based, formal menstruation education programs on adolescent girls, particularly the effects on anxiety and self-efficacy related to the management of menstruation. Furthermore, this work aims to take a stance …

A Tail Of Two Fishes: Exploring Population Structure In Two Species Of Fishes Across The Galápagos Islands, Hillary Quach

Honors Undergraduate Theses

The Galápagos Islands, a UNESCO World Heritage Site and a biodiversity hotspot with high levels of endemism, is home to over 440 species of fishes. Marine conditions across the Archipelago are greatly influenced by ocean currents in the region. The Pacific Equatorial Undercurrent, South Equatorial Current, and the Humboldt Current deliver waters rich in nutrients across the three major regions within the Galápagos (central, north, and west). These conditions create a dynamic environment close to the equator, enabling diverse species to thrive in distinct parts of the Galápagos. Despite the rich biodiversity in the region and diverse oceanographic conditions, there …

Genomic Epidemiology Of Staphylococcus Aureus Sequence-Type 72, Sachitaa Senthilkumar

Honors Undergraduate Theses

Staphylococcus aureus (S. aureus, SA) is a gram-positive bacterial colonizer and pathogen commonly carried on the skin and in the anterior nares of humans. SA colonization may lead to a variety of non-invasive (e.g., skin and soft tissue infections, SSTIs) and invasive (e.g., bacteremia and osteomyelitis) infections. The SA population is comprised of multiple lineages that can be delineated through multi-locus sequence typing (MLST), which compares nucleotide sequences within seven housekeeping genes. Strains belonging to an MLST share a common evolutionary history and phenotypic characteristics like antibiotic resistance or virulence. As a result, the epidemiology of lineages can be …

Effects Of Changes In Strouhal And Reynolds Numbers On Beetle Wing Aerodynamics, Keith L. Thiha

Honors Undergraduate Theses

Insect flight has long been a subject of interest across the scientific community, largely due to the exceptional aerodynamic performance insects demonstrate relative to their size. Insects tend to have very high aerodynamic performance characteristics like thrust and lift generation compared to their size. This has many potential applications in improving aircraft performance, however the flow phenomena concerning insect wing aerodynamics is still an area of ongoing research. This study aims to investigate how variations in key nondimensional flow parameters—specifically the Reynolds number and Strouhal number—affect the aerodynamic performance of beetle wings. Strouhal numbers ranging from 0.2 to 0.6 were …

Flowing Together Or Alone: Impact Of Collaboration In The Metaverse, Fiona Fui-Hoon Nah, Brenda Eschenbrenner, Langtao Chen

Research Collection School Of Computing and Information Systems

The metaverse is the next-generation Internet (Web3) that facilitates social connections and collaborations in a virtual world environment. Given the potential of the metaverse to provide more satisfying and effective means of remote collaborations, exploring the possibility of leveraging the metaverse for these endeavors is warranted. Therefore, an important question to address is whether greater engagement occurs when tasks are completed collaboratively versus individually in the metaverse. We address this question by drawing on flow and transportation theories to hypothesize the effect of carrying out a creative task in the metaverse collaboratively versus alone on one's cognitive absorption, a contextually …

The Gender Wage Gap In An Online Labor Market: The Cost Of Interruptions, Abi Adams, Kotaro Hara, Kristy Milland, Chris Callison-Burch

Research Collection School Of Computing and Information Systems

This paper analyses gender differences in working patterns and wages on Amazon Mechanical Turk, a popular online labour platform. Using information on 2 million tasks, we find no gender differences in task selection nor experience. Nonetheless, women earn 20% less per hour on average. Gender differences in working patterns are a significant driver of this wage gap. Women are more likely to interrupt their working time on the platform with consequences for their task completion speed. A follow-up survey shows that the gender differences in working patterns and hourly wages are concentrated amongst workers with children.

Deep Reinforcement Learning With Explicit Context Representation, Francisco Munguia-Galeano, Ah-Hwee Tan, Ze Ji

Research Collection School Of Computing and Information Systems

Though reinforcement learning (RL) has shown an outstanding capability for solving complex computational problems, most RL algorithms lack an explicit method that would allow learning from contextual information. On the other hand, humans often use context to identify patterns and relations among elements in the environment, along with how to avoid making wrong actions. However, what may seem like an obviously wrong decision from a human perspective could take hundreds of steps for an RL agent to learn to avoid. This article proposes a framework for discrete environments called Iota explicit context representation (IECR). The framework involves representing each state …

Last Digit Tendency: Lucky Number And Psychological Rounding In Mobile Transactions, Hai Wang, Tian Lu, Yingjie Zhang, Yue Wu, Yiheng Sun, Jingran Dong, Wen Huang

Research Collection School Of Computing and Information Systems

The distribution of digits in numbers obtained from different sources reveals interesting patterns. The well-known Benford’s law states that the first digits in many real-life numerical data sets have an asymmetric, logarithmic distribution in which small digits are more common; this asymmetry diminishes for subsequent digits, and the last digit tends to be uniformly distributed. In this paper, we investigate the digit distribution of numbers in a large mobile transaction data set with 835 million mobile transactions and payments made by approximately 460,000 users in more than 300 cities. Although the first digits of the numbers in these mobile transactions …

Your Cursor Reveals: On Analyzing Workers’ Browsing Behavior And Annotation Quality In Crowdsourcing Tasks, Pei-Chi Lo, Ee-Peng Lim

Research Collection School Of Computing and Information Systems

In this work, we investigate the connection between browsing behavior and task quality of crowdsourcing workers performing annotation tasks that require information judgements. Such information judgements are often required to derive ground truth answers to information retrieval queries. We explore the use of workers’ browsing behavior to directly determine their annotation result quality. We hypothesize user attention to be the main factor contributing to a worker’s annotation quality. To predict annotation quality at the task level, we model two aspects of task-specific user attention, also known as general and semantic user attentions . Both aspects of user attention can be …

Demo2test: Transfer Testing Of Agent In Competitive Environment With Failure Demonstrations, Jianming Chen, Yawen Wang, Junjie Wang, Xiaofei Xie, Dandan Wang, Qing Wang, Fanjiang Xu

Research Collection School Of Computing and Information Systems

The competitive game between agents exists in many critical applications, such as military unmanned aerial vehicles. It is urgent to test these agents to reduce the significant losses caused by their failures. Existing studies mainly are to construct a testing agent that competes with the target agent to induce its failures. These approaches usually focus on a single task, requiring much more time for multi-task testing. However, if the previously tested tasks (source tasks) and the task to be tested (target task) share similar agents or task objectives, the transferable knowledge in source tasks can potentially increase the effectiveness of …

Dims: Distributed Index For Similarity Search In Metric Spaces, Yifan Zhu, Chengyang Luo, Tang Qian, Lu Chen, Yunjun Gao, Baihua Zheng

Research Collection School Of Computing and Information Systems

Similarity search finds objects that are similar to a given query object based on a similarity metric. As the amount and variety of data continue to grow, similarity search in metric spaces has gained significant attention. Metric spaces can accommodate any type of data and support flexible distanc e metrics, making similarity search in metric spaces beneficial for many real-world applications, such as multimedia retrieval, personalized recommendation, trajectory analytics, data mining, decision planning, and distributed servers. However, existing studies mostly focus on indexing metric spaces on a single machine, which faces efficiency and scalability limitations with increasing data volume and …

Learning To Rank Aspects And Opinions For Comparative Explanations, Trung Hoang Le, Hady Wirawan Lauw

Research Collection School Of Computing and Information Systems

Comparative recommendation explanations help to make sense of recommendations by comparing a recommended item along some aspects of interest with one or many items being considered. This work extends the notion of comparative explanations, by going beyond merely better/worse statements, to further incorporate aspect-level opinions for more informative comparisons. To enhance the quality of both the personalized recommendation and the explanation, we incorporate optimization objectives that preserve relative rankings of aspects and opinions, in addition to the classical rankings of overall preferences for items. We integrate the multiple ranking objectives and multi-tensor factorization together. Experiments on datasets of different domains …

Weakly-Supervised Semantic Segmentation With Image-Level Labels: From Traditional Models To Foundation Models, Zhaozheng Chen, Qianru Sun

Research Collection School Of Computing and Information Systems

The rapid development of deep learning has driven significant progress in image semantic segmentation—a fundamental task in computer vision. Semantic segmentation algorithms often depend on the availability of pixel-level labels (i.e., masks of objects), which are expensive, time consuming, and labor intensive. Weakly supervised semantic segmentation (WSSS) is an effective solution to avoid such labeling. It utilizes only partial or incomplete annotations and provides a cost-effective alternative to fully supervised semantic segmentation. In this article, our focus is on the WSSS with image-level labels, which is the most challenging form of WSSS. Our work has two parts. First, we conduct …

Synthesizing Multi-Person And Rare Pose Images For Human Pose Estimation, Liuqing Zhao, Zichen Tian, Zou Peng, Richang Hong, Qianru Sun

Research Collection School Of Computing and Information Systems

Human pose estimation (HPE) models underperform in recognizing rare poses because they suffer from data imbalance problems (i.e., there are few image samples for rare poses) in their training datasets. From a data perspective, the most intuitive solution is to synthesize data for rare poses. Specifically, the rule-based methods apply manual manipulations (such as Cutout and GridMask) to the existing data, so the limited diversity of the data constrains the model. An alternative method is to learn the underlying data distribution via deep generative models (such as ControlNet and HumanSD) and then sample “new data” from the distribution. This works …

Drone-Based Multimodal Sensing On Vegetations And Data Analytics For Early Detection Of Gas Leakage From Underground Pipelines, Pengfei Ma

Doctoral Dissertations

"This study explored the feasibility of using multimodal remote sensors in the early detection of natural gas leaks from underground pipelines, as vegetation situated above pipelines can discern microbial changes in soil when affected by gas and exhibit physiological stress symptoms on leaves. Three sensors (RBG, thermal, and hyperspectral cameras) were utilized to monitor vegetation stress as an indicator of gas leaks. A laboratory experiment was conducted to evaluate the workability of vegetation for gas leak detection. Regular hyperspectral imagery was collected from test vegetations to identify gas stress and distinguish it from other environmental stressors such as salinity impact, …

Raft-Based Polymer And Nanoparticle Materials For Traumatic Brain Injury Treatment And Diagnostics, Aaron Priester

Doctoral Dissertations

"Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. Neurodegenerative diseases that develop post-TBI can be, in part, attributed to DNA and cell-damaging reactive oxygen species (ROS) and lipid peroxidation products (LPOx). This thesis focused on overcoming the limits of current TBI material treatment approaches by employing a RAFT (reversible-addition fragmentation chain transfer) polymer approach that incorporated novel therapeutic, diagnostic and peptide-targeting monomers. An improved nanoparticle synthesis approach was also developed. Thiol and thioether-containing monomers neutralize both ROS and LPOx while Gd-containing monomers with enhanced magnetic resonance imaging (MRI) contrast provide diagnostics and material tracking in …

The Evolving Use Of Strategic Planning Tools In The Manufacturing Environment: Implications For Quality 4.0 And Beyond, Richard Lee Wilson

Doctoral Dissertations

"Having a strong strategic plan is critical for success for any business no matter the size of the organization, the product or service they provide, or the industry they serve. There are many methods businesses use to develop their strategic plans. One such method is known as Hoshin Kanri, which has been in use for decades. However, recent years have seen an increase in artificial intelligence, big data, data analytics, and other technology tools to create cyber physical systems on the manufacturing floor. The increase in technology in manufacturing to integrate cyber systems with physical systems spawned a new industrial …

Transport And Plugging Behavior Of Co2-Resistant Preformed Particle Gels In High Conductive Channels For Conformance Control, Adel Alotibi

Doctoral Dissertations

"Improving oil recovery is essential with rising global oil demand and declining production in mature fields. CO₂ flooding has been widely applied as a major Enhanced Oil Recovery (EOR) method due to its effectiveness in boosting oil recovery while enabling safe carbon storage in the subsurface. However, in fractured and highly heterogeneous reservoirs, CO₂ often flows through paths of least resistance, leading to early breakthrough or quick excessive CO₂ production and leaving substantial oil in unswept zones or areas. Traditional in-situ polymer gels have been applied to control CO₂ flooding conformance, their performance has been varied, …

Development And Testing Of Irradiation-Tolerant High-Entropy Alloys, Matthew John Luebbe

Doctoral Dissertations

"High entropy alloys (HEAs) are a novel class of alloys made of multiple principal elements in near equal proportions. They have been observed to possess an array of useful engineering properties, such as good ductility and fracture toughness, high temperature strength, oxidation and corrosion resistance and irradiation resistance. This makes them promising candidates for harsh environments, especially nuclear reactors. These properties could potentially realize advanced Gen IV nuclear reactor designs. However, most HEA compositions contain Co, which activates under irradiation, generating safety and waste management concerns. This work studies three compositions of Co-free HEAs whose strength and microstructures are evaluated …

Ceramic Dielectrics For High Temperature Capacitor Applications, Alan Daniel Devoe

Doctoral Dissertations

Technical progress in microelectronics is allowing operation in environments that were previously considered impossible. Building complete electronic circuits for applications above 450 degrees C, such as the planned NASA missions to Venus, require a variety of active and passive components, including multilayer ceramic capacitors (MLCC).

This study explores calcium zirconate CaZrO3 and magnesium oxide MgO based dielectric compositions for MLCC applications that are capable of operating at extreme temperatures between 450 degrees C and 600 degrees C. Both materials were characterized with respect to impurities, dopants, crystal structure and microstructural development. Dielectric properties were measured to determine permittivity, dissipation factor, …

Quantum And Classical Phase Transitions In Disordered Systems, Gaurav Ramesh Khairnar

Doctoral Dissertations

This work examines the effects of quenched disorder on classical and quantum phase transitions. There are countless examples of phase transitions in nature. Here, we study phase transitions in condensed matter with the help of simple models that focus on the essential unifying features of the problems. We are particularly interested in investigating how the presence of disorder changes the behavior of the system in the vicinity of a phase transition.

Here, we discuss three closely related problems regarding phase transitions. First we consider the behavior of highly diluted magnets with varying dilution levels in order to explain the unusual …

Assessing And Comparing Geophysical Methods For Resolving Shallow Subsurface Geology, Abdullah Basaloom

Doctoral Dissertations

Geophysical methods are essential tools for investigating shallow subsurface structures, offering non-invasive means to characterize geological features and detect anomalies. Techniques such as electrical resistivity tomography (ERT), towed Transient Electromagnetic (tTEM), seismic refraction, magnetic, gravity, and magnetotelluric (MT) are commonly employed to image subsurface conditions with high resolution.

This study started with an in-depth analysis of comparing results co-located in space to assess uncertainties and resolution in the obtained resistivity models in the Kansas River Alluvial Aquifer (KRAA). Our results provided a quantitative interpretation of resistivity estimates between different geo-electrical methods (ERT, tTEM and DPEC). Following this, we provided a …

Enhanced Optimization Of Mass Transfer For Carbon Capture And Wastewater Remediation In Algal Systems Through Algorithmic And Bioprocessing Techniques, Peter Ofuje Obidi

Doctoral Dissertations

The scalability and industrial deployment of algal cultivation systems are limited by suboptimal mass transfer, constraining their effectiveness in carbon capture and wastewater remediation. This research investigated these challenges through integrated optimization methodologies that combine algorithmic frameworks with enhanced bioprocessing techniques to enhance efficiency, economy, and scalability. A System-of-Systems (SoS) meta-architecture was developed using genetic algorithms and fuzzy assessor functions to demonstrate a pathway toward cost reduction. Rigorous mechanical and chemical characterizations were quantitatively analyzed to reveal existing optimization strategies and further evaluated the best strategies to use in enhancing mass transfer for improved biomass yield. The work also integrates …

Flexural Post-Cracking Performance Of Macro Synthetic Fiber Reinforced Super Workable Concrete Influenced By Shrinkage-Reducing Admixture, Jingjie Wei, Nima Farzadnia, Kamal H. Khayat

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

Most literature has focused on the effect of shrinkage-reducing admixture (SRA) in shrinkage mitigation resistance of concrete. This study aims to examine the impact of SRA on the efficiency of macro synthetic fibers (MSF) in enhancing the flexural post-cracking behavior of fiber-reinforced super workable concrete (FR-SWC). A comparative analysis of the influence of fiber combinations on the flexural post-cracking behavior of beams is also included. Results showed that a higher dosage of SRA, particularly at 5 % by mass of binder, had a noticeable negative impact on flexural post-cracking performance of beams while exhibiting positive effect on workability and shrinkage …